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丹黒章

徳島大学

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2024年12月20日更新

職名: 名誉教授 (2021.4)
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学歴: 1981/3: 徳島大学医学部卒業
学位: 医学博士 (山口大学) (1987年3月)
職歴・経歴: 〜: 徳島大学教授, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学教授, 大学院医歯薬学研究部 (-2021.3.)
2021/4: 徳島大学 ○○, 大学院医歯薬学研究部 (-2022.3.)

専門分野・研究分野: 医学 (Medicine)
外科学 (Surgery)

研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
外科学 (Surgery)
担当経験のある授業科目: 研究者総覧に該当データはありませんでした。
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2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
外科学 (Surgery)

研究テーマ: 低侵襲治療 (癌治療, sentinel lymph node)

著書

丹黒章 :
病態栄養専門医テキスト改訂第3版認定専門医を目指すために日本病態栄養学会編, --- Ⅶ章主要疾患の栄養管理 9．悪性腫瘍 ---,
南江堂, 東京, 2021年5月. 丹黒章 :
今日の治療指針2021年版, --- 線維線種 ---,
株式会社医学書院, 東京, 2021年. Akira Tangoku, Takahiro Yoshida, Hiroaki Toba, Hirokazu Takechi, Kazumasa Okumura, Takeshi Nishino, Seiya Inoue, Misako Nakagawa, 森本雅美, Toru Sawada, 青山万理子, 宮本直輝, 西岡康平, 藤本啓介 and Hiromitsu Takizawa :
CT lymphography for superficial esophageal cancer,
2017. Akira Tangoku, Takahiro Yoshida, Hirokazu Takechi, Kazumasa Okumura, Misako Nakagawa, 森本雅美, Takeshi Nishino, Seiya Inoue, Toru Sawada, 青山万理子, 宮本直輝, 西岡康平, 藤本啓介 and Hiroaki Toba :
Molecular diagnosis and targeting therapy for breast cancer,
2017. 丹黒章 :
線維腺腫,
2016年. 丹黒章 :
乳癌センチネルリンパ節診断における3D-CT lymphographyの有用性,
2016年. 丹黒章 :
第3章治療 E. 周術期管理・糖尿病・心血管,
2016年. 丹黒章 :
VII. 主要疾患の栄養管理 9．.悪性腫瘍,
南江堂, 東京(日本国), 2015年8月.

(キーワード): 悪性腫瘍

丹黒章 :
悪性腫瘍,
2015年8月. 丹黒章 :
急性乳腺炎，乳輪下膿瘍,
2015年. 丹黒章 :
センチネルリンパ節生検 : 手技・エビデンス・ピットフォール,
日本医事新報社, 東京, 2012年5月.

(キーワード): センチネルリンパ節

丹黒章 :
乳がんインフォームドコンセントガイド最新の知見から,
日本医事新報社, 東京, 2011年8月.

(キーワード): 乳癌

丹黒章 :
下咽頭頸部食道憩室切除術胸部食道憩室切除術,
中山書店, 東京, 2010年2月. 丹黒章 :
乳腺腫瘤の診察手順,
2010年. 丹黒章, 山本洋太, 武知浩和 :
2. 悪性腫瘍 7.鏡視下手術 B.経縦隔的鏡視下食道切除術,
2010年. Akira Tangoku :
Mediastinoscope-assisted transhiatal esophagectomy,
Springer-Verlag New York, Jul. 2008.

(キーワード): esophageal cancer

中屋豊, 桑波田雅士, 丹黒章, 土井俊夫, 竹谷豊, 野間喜彦, 武田英二, 東博之, 島田光生, 栗田信浩, 大森哲郎, 西正晴, 青野純典, 西岡安彦, 吉本勝彦, ほか 65名 :
NST用語ハンドブック,
メディカルレビュー社, 東京, 2006年2月. 丹黒章 :
食道アカラシア,
朝倉書店, 東京, 2005年. 丹黒章, 山本滋 :
CTを用いたセンチネルリンパ節生検(SLNB)と境視下郭清術,
金原出版株式会社, 2004年.

論文

Naoki Miyamoto, Hiroaki Inoue, Tomohiro Inui, Souichiro Sasa, Mariko Aoyama, Kazumasa Okumura, Hiroaki Toba, Naoki Hino, Aya Nishisho, Yukishige Sawaka, Taeko Kawanaka, Hiromitsu Takizawa and Akira Tangoku :
Absolute Lymphocyte Count Changes During Neoadjuvant Chemotherapy are Associated With Prognosis of Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Patients,
Clinical Breast Cancer, Vol.23, No.3, e68-e76, 2023.

(要約): Some reports have shown that absolute lymphocyte count (ALC) is associated with prognosis in breast cancer; however, the impact of ALC changes remains unclear. This study aimed to investigate the relationship between ALC changes during neoadjuvant chemotherapy for human epidermal growth factor receptor-2 (HER2)-positive breast cancer patients and disease prognosis. This retrospective cohort study January 2010 to September 2020) included patients diagnosed with HER2-positive breast cancer and treated with trastuzumab-based neoadjuvant chemotherapy. The ALC ratio was defined as the ALC value after administration of the anti-HER2 drug divided by the ALC value before administration. The optimal ALC ratio cut-off value was identified using the receiver operating characteristic curve analysis and Youden's index. The relationship between the ALC ratio and disease-free survival was assessed using the Kaplan-Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards model. Data from a total of 100 HER2-positive breast cancer patients were analyzed. The cut-off value of the ALC ratio was set as 1.142. The median follow-up period was 52.0 (range: 5.1-123.7) months. The 5-year disease-free survival rates were 88.4% and 60.9% in the high-and low-ALC ratio groups, respectively, and were significantly higher in the high-ALC ratio group (p = .0031). The ALC ratio was an independent prognostic factor in multivariate Cox proportional hazards analysis (p = .0032). HER2-positive breast cancer patients with a higher ALC ratio during trastuzumab-based neoadjuvant chemotherapy may have a better prognosis than their counterparts.
(キーワード): Humans / 女性 (female) / Breast Neoplasms / Neoadjuvant Therapy / Retrospective Studies / Receptor, ErbB-2 / Prognosis / Trastuzumab / Disease-Free Survival / Lymphocyte Count / Antineoplastic Combined Chemotherapy Protocols
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clbc.2023.01.005
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36682907; ● Summary page in Scopus @ Elsevier: 2-s2.0-85147563272

(DOI: 10.1016/j.clbc.2023.01.005, PubMed: 36682907, Elsevier: Scopus) Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Seiya Inoue, Satoshi Fujiwara, Hiromitsu Takizawa, Akira Tangoku, Hisanori Uehara and Yoshimi Bando :
ypN0 in Patients with Definitive cN-positive Status After Preoperative Treatment Is a Prognostic Factor in Esophageal Cancer,
Anticancer Research, Vol.42, No.1, 195-203, 2022.

(要約): Histopathological tumor regression grade is applied not to lymph nodes but primary tumors modified by preoperative treatments. This study focused on patients whose pathological examination at the time of surgery showed no residual tumor after chemo(radio)therapy in the primary lesion (ypT0) or lymph nodes (ypN0). A total of 87 patients with clinical stage II/III thoracic esophageal cancer underwent esophagectomy following preoperative treatments to evaluate significances between pathological response and clinical outcomes; 51 patients with clinically definitive lymph node metastasis (cN+) were analyzed as a subgroup. ypT0 rates were 20.7% and 23.5%, and ypN0 rates were 47.1% and 27.5% in the whole cohort and in the cN+ subgroup, respectively. Disease-free survival, from surgery to relapse or death, was significantly influenced by ypN status (p=0.035) but not by ypT status in the 51 patients with definitive cN+ disease. Preoperative chemoradiation was an independent favorable factor for achievement of ypN0 in the 51 patients (odds ratio=0.09; p=0.007). ypN status was a predictive factor for DFS in patients treated with docetaxel plus low-dose 5-fluorouracil and cisplatin combined chemotherapy, superior to ypT status, especially in patients with definitive cN+ disease.
(キーワード): Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Chemoradiotherapy, Adjuvant / Cisplatin / Disease-Free Survival / Esophageal Neoplasms / Esophageal Squamous Cell Carcinoma / Esophagectomy / Female / Fluorouracil / Humans / Lymph Nodes / Lymphatic Metastasis / Male / Middle Aged / Neoadjuvant Therapy / Neoplasm Grading / Preoperative Care
(出版サイトへのリンク): ● Publication site (DOI): 10.21873/anticanres.15473
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34969725; ● Search Scopus @ Elsevier (PMID): 34969725; ● Search Scopus @ Elsevier (DOI): 10.21873/anticanres.15473

(DOI: 10.21873/anticanres.15473, PubMed: 34969725) Ayumi Izumori, Masako Takahashi, Souichiro Sasa, Hiroaki Inoue, Akira Tangoku, Miyuki Kanematsu and 笹三徳 :
False-negatives due to poor specimens can be prevented based on the macroscopic findings for breast Vacuum-Assisted Biopsy specimens,
The Journal of Medical Investigation : JMI, Vol.69, No.1.2, 51-64, 2022.

(要約): Ultrasound-guided breast tissue biopsy is an essential technique for diagnosing breast disease, but sample errors reduce its accuracy. This study investigated whether the histopathological results can be inferred from the macroscopic findings for Ultrasound-guided breast Vacuum Assisted Biopsy (VAB) specimens. Biopsy specimens from 101 patients who underwent mammary gland VAB were photographed with a smartphone, and the relationships between the macroscopic findings and the pathological results were examined. A significant difference was observed with regard to the presence/absence of turbidity: malignancy was detected in 33/37 (89%) specimens with turbidity and in 2/47 (4%) cases without turbidity (p<0.001). A significant difference was also observed regarding the surface properties:malignancy was detected in 14/70 (19%) smooth specimens and in 24/29 (83%) rough specimens (p<0.001). Also, malignancy was detected in 11/13 (85%) specimens with white spots, and the difference was significant (p<0.001). In addition, the characteristics of intraductal papilloma, fibroadenoma, and mastopathy could be confirmed by macroscopic findings. When needle-biopsy of a lesion that is targeted for resection yields macroscopic findings that match the predicted histopathological findings, it can be thought that the biopsy had been properly performed. This means that false-negatives due to poor specimens can be prevented. J. Med. Invest. 69 : 51-56, February, 2022.
(キーワード): VAB / skill of the operator / histopathological findings / accuracy / sample errors
(徳島大学機関リポジトリ): ● Metadata: 117012
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.69.51
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35466146; ● CiNii @ 国立情報学研究所 (CRID): 1390010457641004800; ● Summary page in Scopus @ Elsevier: 2-s2.0-85128801196

(徳島大学機関リポジトリ: 117012, DOI: 10.2152/jmi.69.51, PubMed: 35466146, CiNii: 1390010457641004800, Elsevier: Scopus) Yukikiyo Kawakami, Hiromitsu Takizawa, Hiroaki Toba, Naoya Kawakita, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Diversity of lymphatic flow in patients with lung cancer revealed by computed tomography lymphography,
Interactive Cardiovascular and Thoracic Surgery, Vol.33, No.6, 871-878, 2021.

(要約): This study was conducted to verify the optimal extent of lymph node dissection or sampling during lung cancer surgery based on the sentinel node (SN) map created by computed tomography (CT) lymphography. From April 2010 to January 2015, patients with clinical stage I non-small-cell lung cancer, who were candidates for lobectomy or segmentectomy with standard hilar and mediastinal lymph node dissection, and in whom bronchus reached the tumour, were enrolled. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. CT images of the chest were obtained 30 s after 2.5 ml of iopamidol was injected. SNs were identified when the maximum CT attenuation value of the lymph nodes on postcontrast CT images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. SNs were identified in 36 (87.8%) of the 41 patients. The average number of SNs was 1.6 (range, 1-4). There was 1 false negative case; therefore, the accuracy of SN identification was 97.2% (35/36). In 5 (13.9%) of 36 patients, SNs were outside the lobe-specific lymph node station range (#11i from right S1, #7 from right S1, #4R from right S8, #12u from right S8, #7 and #12l from left S1 + 2). CT lymphography demonstrated the diversity of lymphatic spreading patterns and there were cases in which lymph flows are found outside the lymph node dissection range.
(キーワード): Carcinoma, Non-Small-Cell Lung / Contrast Media / Humans / Lung Neoplasms / Lymph Nodes / Lymphography / Neoplasm Staging / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivab204
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34322701; ● Summary page in Scopus @ Elsevier: 2-s2.0-85121244779

(DOI: 10.1093/icvts/ivab204, PubMed: 34322701, Elsevier: Scopus) Bilguun Tegshee, Kazuya Kondo, Shiho Soejima, Kyoka Muguruma, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
GHSR methylation-dependent expression of a variant ligand and receptor of the ghrelin system induces thymoma tumorigenesis,
Oncology Letters, Vol.22, No.5, 793, 2021.

(要約): Our previous study reported that the DNA methylation of growth hormone secretagogue receptor () was significantly higher in thymoma or thymic carcinoma (TC) than in normal thymic tissue samples. Thymic epithelial tumors (TETs) with higher DNA methylation were associated with significantly worse prognosis than those with lower levels of DNA methylation. Diversified components of the ghrelin- axis may exert opposing effects in cancer progression, depending on the cancer type in question. However, the precise function of the axis remains unclear. In the present study, the mRNA expression of five key components of the ghrelin system [native ligand ghrelin, variant ligand In-1 ghrelin, native receptor GHSR1a, variant receptor GHSR1b and acylation enzyme ghrelin O-acyltransferase (GOAT)] were examined in 58 TET samples by reverse transcription-quantitative PCR, and protein expression of GHSR1a and GHSR1b was assessed in 20 TETs using immunohistochemistry. The results revealed that In-1 ghrelin, GHSR1b (variant forms) and GOAT were more strongly expressed in thymoma compared with thymic-adjacent tissue. By contrast, no significant differences were observed in the expression of ghrelin and GHSR1a (native forms) between thymoma and thymic tissue. The mRNA expression of In-1 ghrelin and GHSR1b (variant forms) was positively associated with methylation in thymoma tissue samples. However, a relationship was not found between ghrelin, GHSR1a or GOAT expression (native forms) and methylation in thymoma. Immunohistochemical analysis revealed that mRNA expression of GHSR1a and GHSR1b generally correlated with expression of the corresponding protein, and that the expression of GHSR1b was increased in advanced-stage TETs. These results indicate that the DNA methylation of is associated with a shift from native expression (ghrelin and GHSR1a) to variant expression (In-1 ghrelin and GHSR1b), which induces the tumorigenesis of thymoma, but not TC.
(徳島大学機関リポジトリ): ● Metadata: 116971
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2021.13054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34630704; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115236793

(徳島大学機関リポジトリ: 116971, DOI: 10.3892/ol.2021.13054, PubMed: 34630704, Elsevier: Scopus) 宮本直輝, 井上寛章, 乾友浩, 笹聡一郎, 青山万理子, 鳥羽博明, 奥村和正, 吉田卓弘, 滝沢宏光, 丹黒章 :
HER2陽性乳癌患者における術前化学療法開始前の総リンパ球数は予後予測の指標となり得る,
四国医学雑誌, Vol.77, No.3,4, 131-136, 2021年.

(要約): Purpose : Several studies have shown that peripheral hematologic parameters, such as the absolute lymphocyte count(ALC)and neutrophil to lymphocyte ratio(NLR)can predict the prognosis for malignant tumor. We investigated the relation of these parameter and prognosis before neoadjuvant chemotherapy for human epidermal growth factor receptor-2(HER2)-positive breast cancer patients. Methods : From April 2009 to March 2019, 85 patients diagnosed with HER2‐positive breast cancer and treated with trastuzumab-based neoadjuvant chemotherapy were included in this retrospective cohort study. The optimal cut-off for the NLR and ALC was identified using the receiver operating characteristic(ROC)curve analysis and Youden's index. Results : The median age of patients at the start of treatment was 58．9(range 32‐81)years. The median follow-up time for HER2-positive breast cancer patients was 52．0(range:9．8‐114．3)months. In this period, 11 patients developed recurrence. The low-ALC group showed better disease free survival than the high-ALC group(p=0．0482). There was no significant difference in disease free survival between the low- and high-NLR groups. Conclusion : ALC before neoadjuvant chemotherapy may be a predictor of prolonged disease free survival in HER2‐positive breast cancer patients.
(キーワード): HER2陽性乳癌 / 総リンパ球数 / 周術期化学療法 / HER2 breast cancer / neoadjuvant chemotherapy / absolute lymphocyte counts
(徳島大学機関リポジトリ): ● Metadata: 116396
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520853835244402176

(徳島大学機関リポジトリ: 116396, CiNii: 1520853835244402176) Shin Kondo, Tatsuro Inoue, Takahiro Yoshida, Takashi Saito, Seiya Inoue, Takeshi Nishino, Masakazu Goto, Nori Sato, Rei Ono, Akira Tangoku and Shinsuke Katoh :
Impact of preoperative 6-minute walk distance on long-term prognosis after esophagectomy in patients with esophageal cancer.,
Esophagus, Vol.19, No.1, 95-104, 2021.

(要約): The median follow-up period was 923 days. Thirty-three deaths were recorded during the study period. After PSM, 5-year OS following surgery was 29.2 and 66.1% (p = 0.003) and 5-year RFS was 27.9 and 58.6% (p = 0.021) in the SG and LG, respectively. In Cox proportional hazards analysis, the SG was a significant independent risk factor for OS (hazard ratio 3.33; 95% confidence interval 1.37-8.11, p = 0.008) and RFS (hazard ratio 2.30; 95% confidence interval 1.08-4.88, p = 0.030).
(キーワード): Esophageal Neoplasms / Esophagectomy / Humans / Neoplasm Recurrence, Local / Prognosis / Retrospective Studies
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-021-00871-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34383155; ● Search Scopus @ Elsevier (PMID): 34383155; ● Search Scopus @ Elsevier (DOI): 10.1007/s10388-021-00871-9

(DOI: 10.1007/s10388-021-00871-9, PubMed: 34383155) Hiromitsu Takizawa, Naoki Miyamoto, Shinichi Sakamoto, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Hypervascularized bronchial arteries as a risk factor for intraoperative bleeding and prolonged surgery,
Journal of Thoracic Disease, Vol.13, No.8, 4731-4741, 2021.

(要約): The present study investigated whether highly vascularized bronchial arteries affect the intraoperative blood loss and the operative time of video-assisted thoracic surgery (VATS) lobectomy for patients with non-small cell lung cancer. We retrospectively collected data on consecutive pathological stage I to IIIA non-small cell lung cancer patients who underwent VATS lobectomy with systematic lymph node dissection between January 2017 and December 2019. Patients were divided into the following two groups according to bronchial artery diameters on preoperative enhanced contrast computed tomography (CT) findings: ≤2 and >2 mm groups. Among the 175 patients enrolled, risk factors for intraoperative blood loss >50 mL were being male (P=0.005), a history of smoking (P=0.01), percent forced expiratory volume in 1 s (FEV1.0%) <70% (P=0.012), squamous cell carcinoma (P=0.049), and a bronchial artery diameter >2.0 mm (P<0.001) in the unadjusted analysis, and a bronchial artery diameter >2.0 mm (P<0.001) in the multivariable analysis. Risk factors for an operative time >200 min were being male (P<0.001), a history of smoking (P=0.007), FEV1.0% <70% (P=0.011), squamous cell carcinoma (P=0.046), a bronchial artery diameter >2.0 mm (P<0.001), and experience of surgeon <10 years (P=0.011) in the unadjusted analysis, and being male (P=0.047), a bronchial artery diameter >2.0 mm (P=0.024), and experience of surgeon <10 years (P=0.047) in the multivariable analysis. Bronchial artery diameter was the most important risk factor of intraoperative bleeding and prolonged operative time during VATS lobectomy.
(徳島大学機関リポジトリ): ● Metadata: 116933
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd-21-616
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34527314; ● Summary page in Scopus @ Elsevier: 2-s2.0-85113478594

(徳島大学機関リポジトリ: 116933, DOI: 10.21037/jtd-21-616, PubMed: 34527314, Elsevier: Scopus) Toru Sawada, Hiromitsu Takizawa, Mariko Aoyama, Naoya Kawakita, Naoki Miyamoto, Shinichi Sakamoto, Mika Takashima, Daisuke Matsumoto, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Diagnosis of visceral pleural invasion using confocal laser endomicroscopy during lung cancer surgery,
Journal of Thoracic Disease, Vol.13, No.8, 4742-4752, 2021.

(要約): Visceral pleural invasion (VPI) in lung cancer is a significant prognostic factor; however, it is difficult to diagnose preoperatively or intraoperatively. In this study, we examined the possibility of intraoperative diagnosis of VPI using confocal laser endomicroscopy (CLE). Among patients with primary lung cancer who underwent surgery between April 2018 and August 2019, those in whom the tumor was in contact with the pleura on chest computed tomography and whose pleural changes were intraoperatively confirmed were enrolled in this study. In the 35 patients who underwent lung resection (6 cases with visceral pleural infiltration), the area where pleural change was noted was observed and a short video was recorded using CLE. Based on the video images, three evaluators determined the defect ratio (0%, 25%, 50%, 75%, and 100%) of the autofluorescence-positive structure. The area under the receiver operating characteristic curve was used to evaluate the diagnostic performance for VPI. In 15 cases (3 cases with VPI), a validation study was performed for intraoperative VPI according to the cutoff value of the defect ratio of the autofluorescence-positive structure. The areas under the receiver operating characteristic curve for the defect ratio of the autofluorescence-positive structure were 0.86-0.91 for the three readers. Using defect ratio of autofluorescence-positive structure cutoff of ≥50% as predictor of VPI, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 83.3-100.0%, 57.7-73.1%, 35.3-41.7%, 95.0-100.0%, and 75.0-78.1%, respectively, for the three readers. In the validation study, the sensitivity was 100%, the specificity was 83.3%, and the diagnostic accuracy rate was 86.7%. The diagnosis of VPI through CLE is simple, non-invasive, and has high diagnostic accuracy rates. This method may be applicable for determining surgical procedures.
(徳島大学機関リポジトリ): ● Metadata: 116384
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd-21-137
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34527315; ● Summary page in Scopus @ Elsevier: 2-s2.0-85113558883

(徳島大学機関リポジトリ: 116384, DOI: 10.21037/jtd-21-137, PubMed: 34527315, Elsevier: Scopus) 丹黒章, 滝沢宏光, 吉田卓弘, 後藤正和, 井上聖也, 都築英雄 :
食道癌手術における高度胸膜癒着症例への対処,
手術, Vol.75, No.7, 1069-1074, 2021年.

(キーワード): 胸膜癒着 / 食道亜全摘術 / 縦隔鏡下食道切除術 / キョウマクユチャク / ショクドウアゼンテキジュツ / ジュウカクキョウカショクドウセツジョジュツ
(出版サイトへのリンク): ● Publication site (DOI): 10.18888/op.0000002281
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390569932783885568; ● Search Scopus @ Elsevier (DOI): 10.18888/op.0000002281

(DOI: 10.18888/op.0000002281, CiNii: 1390569932783885568) Shiho Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, Kyoka Muguruma, B Tegshee, Yukikiyo Kawakami, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors,
Oncology Letters, Vol.21, No.6, 483, 2021.

(要約): Thymic epithelial tumors (TETs) comprise thymomas and thymic carcinoma (TC). TC has more aggressive features and a poorer prognosis than thymomas. Genetic and epigenetic alterations in thymomas and TC have been investigated in an attempt to identify novel target molecules for TC. In the present study, genome-wide screening was performed on aberrantly methylated CpG islands in thymomas and TC, and the glutamate decarboxylase 1 gene () was identified as the 4th significantly hypermethylated CpG island in TC compared with thymomas. catalyzes the production of γ-aminobutyric acid from L-glutamic acid. expression is abundant in the brain but rare in other tissues, including the thymus. A total of 73 thymomas and 17 TC tissues were obtained from 90 patients who underwent surgery or biopsy at Tokushima University Hospital between 1990 and 2017. DNA methylation was examined by bisulfite pyrosequencing, and the mRNA and protein expression levels of were analyzed using reverse transcription-quantitative PCR and immunohistochemistry, respectively. The DNA methylation levels of were significantly higher in TC tissues than in the normal thymus and thymoma tissues, and methylation exhibited high sensitivity and specificity for discriminating between TC and thymoma. The mRNA and protein expression levels of were significantly higher in TC tissues than in thymomas. Patients with TET with high DNA hypermethylation and high mRNA and protein expression levels had significantly shorter relapse-free survival rates than those with low levels. In conclusion, significantly more epigenetic alterations were observed in TC tissues compared with in thymomas, which may contribute to the clinical features and prognosis of patients.
(徳島大学機関リポジトリ): ● Metadata: 116970
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2021.12744
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33968199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85105632213

(徳島大学機関リポジトリ: 116970, DOI: 10.3892/ol.2021.12744, PubMed: 33968199, Elsevier: Scopus) Takeshi Nishino, Hiroaki Toba, Takahiro Yoshida, Seiya Inoue, Masakazu Goto, Naoya Kawakita, Hiromitsu Takizawa, Yoshihiro Tsuruo and Akira Tangoku :
Endobronchial Ultrasound Improves the Diagnosis of the Tracheobronchial Invasion of Advanced Esophageal Cancer,
Annals of Surgical Oncology, Vol.28, No.11, 6398-6406, 2021.

(要約): Accurate diagnosis of the tracheobronchial invasion of advanced esophageal cancer is essential to select appropriate treatment and improve prognosis; however, it is difficult using the conventional modalities. This study aimed to clarify the diagnostic usefulness of convex probe endobronchial ultrasound (CP-EBUS) for the diagnosis of the tracheobronchial invasion of advanced esophageal cancer. We conducted a cadaveric study to clarify the changes in ultrasonic and histopathologic findings in the esophageal tumor and tracheal invasion models. Additionally, we examined CP-EBUS for patients with advanced thoracic esophageal cancer in whom tracheobronchial invasion was suspected on contrast-enhanced computed tomography (CE-CT) scan. We retrospectivity evaluated the diagnosis of CP-EBUS, comparing the pathological findings and treatment outcomes. Cadaveric esophageal tumor and tracheal invasion models showed the disappearance of the third layer observed with CP-EBUS and histologically proven interruption of the adventitia. This indicated that the third layer corresponded with the tracheal adventitia. We examined 40 patients with advanced thoracic esophageal cancer in whom tracheobronchial invasion was suspected. The precise diagnosis was pathologically confirmed in 9 of 14 patients diagnosed with cT3 who underwent radical surgery. 20 of 26 cases diagnosed with cT4b received definitive chemoradiotherapy, and 4 cases received salvage surgery and pathologically confirmed precise diagnosis. CP-EBUS is extremely useful for diagnosing the tracheobronchial invasion of advanced esophageal cancer. It could be an effective modality for determining treatment strategies in cases with a marginal surgical indication.
(キーワード): Bronchoscopy / Endosonography / Esophageal Neoplasms / Humans / Lung Neoplasms / Tomography, X-Ray Computed / Trachea
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-021-09912-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33826003; ● Summary page in Scopus @ Elsevier: 2-s2.0-85103949292

(DOI: 10.1245/s10434-021-09912-0, PubMed: 33826003, Elsevier: Scopus) 澤田徹, 吉田光輝, 梶浦耕一郎, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡の破損を分析する,
気管支学, Vol.43, No.2, 91-96, 2021年.

(要約): 背景．気管支鏡は超音波内視鏡，ステント，気管支充填術，また当科においては，術前コイルマーキングなど，様々な手技に使用されている．同時に，気管支鏡操作も複雑になり，様々な外力がかかることで破損が起こりやすくなる．気管支鏡の故障は医療経済面での不利益のみならず，合併症発生の増加や，修理期間中の検査・治療が中断されることによる患者側の不利益につながる．目的．当院で経験した気管支鏡の破損について検討し，その原因について探求し，今後の予防策や注意点に関して検討する．方法．2015年1月から2017年11月において当科で気管支鏡検査を施行した246例のうち，気管支鏡修理状況について，気管支鏡の種類や破損原因，修理費などについて検討した．結果．246例中3例(4本)の破損を認め，破損率は1.2%であった．気管内レーザー焼灼術による破損の1例(2本)は，吸引鉗子口の先端の熱損傷による破損であった．生検による破損の1例は湾曲部の鉗子操作によるものであり，超音波気管支鏡の破損の1例は，穿刺針による湾曲部の損傷によるものであった．結論．全例が手技的な要因で発生しており，機器の構造の理解不足や手技の不安定さが原因であった．気管支鏡破損は，経済面や安全面，時間的損失に影響を及ぼす．破損を起こさないためには，手技の向上や気管支鏡構造の理解が必要である．我々が取り組む方策は，気管支鏡内部構造の特性の理解，安定した手技の取得に至る講習，教育を常に意識して実行することである．
(キーワード): 破損 / 分析 / 気管支鏡 / 修理 / 故障 / Damage / Analyze / Bronchoscopy / Repair / Breakdown
(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.43.2_91
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390569070681319424; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.43.2_91

(DOI: 10.18907/jjsre.43.2_91, CiNii: 1390569070681319424) Naoya Kawakita, Hiromitsu Takizawa, Hiroaki Toba, Shinichi Sakamoto, Naoki Miyamoto, Daisuke Matsumoto, Mika Takashima, Mitsuhiro Tsuboi, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Cone-beam computed tomography versus computed tomography-guided ultrathin bronchoscopic diagnosis for peripheral pulmonary lesions: A propensity score-matched analysis,
Respirology, Vol.26, No.5, 477-484, 2021.

(要約): CBCT-guided TBB using a UTB under VBN is a useful method for the diagnosis of peripheral small pulmonary lesions. CBCT-guided TBB using UTB under VBN has been used as an alternative to CT-guided TBB. However, the advantage of CBCT-guided TBB using UTB under VBN over CT-guided TBB is still unknown. This study aimed to compare the diagnostic yield of CT-guided TBB and CBCT-guided TBB using a propensity score-matched analysis. Patients with peripheral pulmonary lesions ≤30 mm were included. Lesions whose bronchus could not be determined by CT were excluded. A UTB and biopsy forceps were advanced to the target bronchus under VBN, 2D-fluoroscopy and CT or CBCT. The CT-guided and CBCT-guided groups were matched for their propensity scores based on patient characteristics. We retrospectively reviewed 93 patients in the CT-guided group and 79 patients in the CBCT-guided group for this study. Furthermore, 48 distinct examination pairs were generated by propensity score matching. In the overall diagnostic yield, the CBCT-guided group showed better results (72.9%) than did the CT-guided group (47.9%) (P = 0.012). The median examination time lasted for 43 (IQR: 37-51) min in the CBCT-guided group and 50 (IQR: 43-62) min in the CT-guided group. The examination time in the CBCT-guided group was significantly shorter than that of the CT-guided group (P = 0.001). CBCT-guided TBB had a better diagnostic yield and shorter examination time than did CT-guided TBB.
(キーワード): Bronchoscopy / Cone-Beam Computed Tomography / Humans / Lung Neoplasms / Propensity Score / Retrospective Studies / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/resp.14016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33615626; ● Summary page in Scopus @ Elsevier: 2-s2.0-85101160064

(DOI: 10.1111/resp.14016, PubMed: 33615626, Elsevier: Scopus) Mitsuteru Yoshida, Masao Yuasa, Hirohisa Ogawa, Naoki Miyamoto, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Can Computed Tomography Differentiate Adenocarcinoma In Situ from Minimally Invasive Adenocarcinoma?,
Thoracic Cancer, Vol.12, No.7, 1023-1032, 2021.

(要約): Given the subtle pathological signs of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), effective differentiation between the two entities is crucial. However, it is difficult to predict these conditions using preoperative computed tomography (CT) imaging. In this study, we investigated whether histological diagnosis of AIS and MIA using quantitative three-dimensional CT imaging analysis could be predicted. We retrospectively analyzed the images and histopathological findings of patients with lung cancer who were diagnosed with AIS or MIA between January 2017 and June 2018. We used Synapse Vincent (v. 4.3) (Fujifilm) software to analyze the CT attenuation values and performed a histogram analysis. There were 22 patients with AIS and 22 with MIA. The ground-glass nodule (GGN) rate was significantly higher in patients with AIS (p < 0.001), whereas the solid volume (p < 0.001) and solid rate (p = 0.001) were significantly higher in those with MIA. The mean (p = 0.002) and maximum (p = 0.025) CT values were significantly higher in patients with MIA. The 25th, 50th, 75th, and 97.5th percentiles (all p < 0.05) for the CT values were significantly higher in patients with MIA. We demonstrated that quantitative analysis of 3D-CT imaging data using software can help distinguish AIS from MIA. These analyses are useful for guiding decision-making in the surgical management of early lung cancer, as well as subsequent follow-up.
(キーワード): Adenocarcinoma / Adenocarcinoma in Situ / Aged / Female / Humans / Male / Retrospective Studies / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 116982
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/1759-7714.13838
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33599059; ● Search Scopus @ Elsevier (PMID): 33599059; ● Search Scopus @ Elsevier (DOI): 10.1111/1759-7714.13838

(徳島大学機関リポジトリ: 116982, DOI: 10.1111/1759-7714.13838, PubMed: 33599059) Naoki Miyamoto, Mitsuteru Yoshida, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Hisashi Ishikura and Akira Tangoku :
Classifying the destination of right top pulmonary vein in 31 clinical cases,
General Thoracic and Cardiovascular Surgery, Vol.69, No.8, 1192-1195, 2021.

(要約): Disruption in the flow of blood vessels is of great concern during thoracic surgery. Preoperative 3-dimensional computed tomography facilitates visualization of the exact location and course of blood vessels. The right posterior upper lobe segmental vein, known as the right top pulmonary vein (RTPV), is an anomalous vein beginning at the right upper lobe and running through the posterior surface of the intermediate bronchus. We clinically investigated 31 patients with RTPV who underwent lobectomy or total resection of the right lung in our hospital or related institutions. We classified the final destination of RTPV into four types. The RTPV flowed into the left atrium in 35.5% of cases, superior pulmonary vein in 9.7%, inferior pulmonary vein in 41.9%, and independently into V6 in 12.9%. An RTPV with a diameter ≥ 5 mm was considered a main drainage vein in S2. We should pay attention to the RTPV during right lung lobectomy.
(キーワード): Bronchi / Humans / Lung / Lung Neoplasms / Pulmonary Veins / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-021-01604-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33586095; ● Search Scopus @ Elsevier (PMID): 33586095; ● Search Scopus @ Elsevier (DOI): 10.1007/s11748-021-01604-6

(DOI: 10.1007/s11748-021-01604-6, PubMed: 33586095) Mitsuteru Yoshida, Masao Yuasa, Kazuya Kondo, Mitsuhiro Tsuboi, Naoya Kawakita and Akira Tangoku :
Evaluation of extended thymectomy approaches based on residual fat tissue,
Interactive Cardiovascular and Thoracic Surgery, Vol.32, No.2, 250-255, 2021.

(要約): This study analysed the patterns of extraction ranges, characteristics, advantages and disadvantages of median sternotomy (MS) and subxiphoid (SX) approaches for extended thymectomy. This study included patients with anterior mediastinum tumour and myasthenia gravis who underwent extended thymectomy at our institution between 2015 and 2018. There were 5 MS and 6 SX extended thymectomy surgeries with the VINCENT software. On preoperative computed tomography, the thymus area and fat tissue surrounding the thymus, which were planned for extraction, were traced using VINCENT (Ver. 4.0). We then constructed three-dimensional images and calculated the volumes. Evaluation of the extended thymectomy approach based on the residual fat tissue was required to determine the area of extended thymectomy. No significant differences in operation time (min) [SX: 197.3 ± 34.0, MS: 206.6 ± 91.4, drainage duration (days), SX: 2.2 ± 1.0, MS: 2.2 ± 0.4, hospital stay (days), SX: 11.8 ± 1.2, MS: 13.4 ± 2.1, residual rate (%), SX: 29.9 ± 17.5, MS: 58.7 ± 18.0 (P = 0.0519)] were observed between the 2 groups. Bleeding was significantly lower for SX than for MS. The residual rate was lower for SX than for MS. Considering the amount of the residual fat tissue, the SX approach allows an adequate dissection area for extended thymectomy compared with the MS approach.
(キーワード): Adult / Disease Progression / Humans / Length of Stay / Male / Mediastinal Neoplasms / Mediastinum / Middle Aged / Myasthenia Gravis / Operative Time / Sternotomy / Thoracic Surgery, Video-Assisted / Thymectomy / Thymoma / Thymus Neoplasms / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivaa242
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33236060; ● Summary page in Scopus @ Elsevier: 2-s2.0-85100360202

(DOI: 10.1093/icvts/ivaa242, PubMed: 33236060, Elsevier: Scopus) Shinichi Sakamoto, Hiromitsu Takizawa, Naoya Kawakita and Akira Tangoku :
Lobectomy for lung cancer with a displaced left B^{1 + 2} and an anomalous pulmonary vein: a case report,
Journal of Cardiothoracic Surgery, Vol.16, No.1, 15, 2021.

(要約): A displaced left B accompanied by an anomalous pulmonary vein is a rare condition involving complex structures. There is a risk of unexpected injuries to bronchi and blood vessels when patients with such anomalies undergo surgery for lung cancer. A 59-year-old male with suspected lung cancer in the left lower lobe was scheduled to undergo surgery. Chest computed tomography revealed a displaced B and hyperlobulation between S and S, while the interlobar fissure between S and S was completely fused. Three-dimensional computed tomography (3D-CT) revealed an anomalous V joining the left inferior pulmonary vein and a branch of the V running between S and S. We performed left lower lobectomy via video-assisted thoracic surgery, while taking care with the abovementioned anatomical structures. The strategy employed in this operation was to preserve V and confirm the locations of B and B when dividing the fissure. The aim of the surgical procedure performed in this case was to divide the fissure between S and the inferior lobe to reduce the risk of an unexpected bronchial injury. 3D-CT helps surgeons to understand the stereoscopic positional relationships among anatomical structures.
(キーワード): Bronchi / Humans / Imaging, Three-Dimensional / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Pulmonary Veins / Thoracic Surgery, Video-Assisted / Tomography, X-Ray Computed / Vascular Malformations
(徳島大学機関リポジトリ): ● Metadata: 117557
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13019-021-01392-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33478540; ● Search Scopus @ Elsevier (PMID): 33478540; ● Search Scopus @ Elsevier (DOI): 10.1186/s13019-021-01392-3

(徳島大学機関リポジトリ: 117557, DOI: 10.1186/s13019-021-01392-3, PubMed: 33478540) Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Mariko Aoyama, Naoya Kawakita, Yota Yamamoto, Yoshihito Furukita, Hiromitsu Takizawa and Akira Tangoku :
Biomarkers predicting the response to chemotherapy and the prognosis in patients with esophageal squamous cell carcinoma.,
General Thoracic and Cardiovascular Surgery, Vol.69, No.3, 525-533, 2021.

(要約): The prognosis of patients with esophageal squamous cell carcinoma (ESCC) has been improved by multidisciplinary therapy with chemoradiotherapy and surgery, but it remains poor. Advanced stage, malignant potential, and chemo-resistance contribute to the poor prognosis. Here, we attempted to identify predictive factors of the response to chemotherapy and the prognosis of ESCC patients. We examined 51 ESCC patients who were treated with chemotherapy followed by radical surgery, and 23 patients who were treated with chemotherapy alone. We conducted quantitative reverse transcription-polymerase chain reaction gene expression analysis using RNA extracted from 74 tumor tissue samples collected before chemotherapy and 67 tumor tissue samples collected after chemotherapy, focusing on PIK3CA, AKT-1, mTOR, 4E-BP1, p70S6K, PD-L1, and PD-L2. The proportions of patients with high expressions of AKT-1 and PD-L1 before chemotherapy were significantly higher among the non-responders than among the responders (p = 0.034, p = 0.020, respectively). Multivariate analyses revealed that high PD-L1 expression before chemotherapy was associated with poor response to chemotherapy (odds ratio 2.998; 95% CI 1.043-8.619; p = 0.042) and high p70S6K expression before chemotherapy was a poor prognostic factor (hazard ratio 2.518; 95% CI 1.058-5.988; p = 0.037). In addition, the patients with high expression of PD-L1 and PD-L2 in the tumors after chemotherapy had significantly worse survival than those with low expression of these genes (p = 0.012, p = 0.007, respectively). These results demonstrated that PD-L1 and p70S6K in the primary ESCC tissues were related to a poor response to chemotherapy and poor prognosis, respectively.
(キーワード): Biomarkers, Tumor / Chemoradiotherapy / Esophageal Neoplasms / Esophageal Squamous Cell Carcinoma / Humans / Prognosis
(徳島大学機関リポジトリ): ● Metadata: 115936
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-021-01586-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33449265; ● Summary page in Scopus @ Elsevier: 2-s2.0-85099215910

(徳島大学機関リポジトリ: 115936, DOI: 10.1007/s11748-021-01586-5, PubMed: 33449265, Elsevier: Scopus) Hiroaki Toba, Naoya Kawakita, Mika Takashima, Daisuke Matsumoto, Hiromitsu Takizawa, Hideki Otsuka and Akira Tangoku :
Diagnosis of recurrence and follow-up using FDG-PET/CT for postoperative non-small-cell lung cancer patients,
General Thoracic and Cardiovascular Surgery, Vol.69, No.2, 311-317, 2021.

(要約): There is currently no consensus regarding the best program for postoperative follow-up and surveillance after a curative resection for non-small-cell lung cancer (NSCLC) patients. We examined the diagnostic capability of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for detecting recurrence in postoperative NSCLC patients, and we evaluated the results of postoperative surveillance using FDG-PET/CT in asymptomatic patients. Between 2005 and 2013, 496 FDG-PET/CT examinations were performed to detect recurrences for 187 NSCLC patients who had undergone potentially curative operations at our institution. Follow-up FDG-PET/CT was performed ≥ 1 × /year in principle in 172 asymptomatic patients without clinical or radiological evidence of recurrence, and the results were retrospectively reviewed. FDG-PET/CT correctly diagnosed recurrence in 46 of 47 (97.9%) patients and 68 of 69 (98.6%) recurrent sites. The following were obtained: 97.9% sensitivity, 97.1% specificity, 92.0% positive predictive value, 99.3% negative predictive value, and 97.3% accuracy. In six patients, other diseases were detected and treated appropriately. In asymptomatic patients, the detection rate of recurrence in the stage III group was significantly higher than the detection rates in the stage I and II groups, and FDG-PET/CT performed ≤ 3 years post-resection detected significantly more FDG-positive lesions compared to that performed after 4 years. FDG-PET/CT is very useful for detecting recurrence in NSCLC patients after a potentially curative operation. It might be sufficient to perform follow-up FDG-PET/CT until 3 years post-resection for advanced-stage patients. Further randomized clinical trials are needed to determine whether the early detection of recurrences leads to better prognoses.
(キーワード): Carcinoma, Non-Small-Cell Lung / Fluorodeoxyglucose F18 / Follow-Up Studies / Humans / Lung Neoplasms / Neoplasm Recurrence, Local / Positron Emission Tomography Computed Tomography / Positron-Emission Tomography / Radiopharmaceuticals / Retrospective Studies / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-020-01477-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32909168; ● Summary page in Scopus @ Elsevier: 2-s2.0-85090755529

(DOI: 10.1007/s11748-020-01477-1, PubMed: 32909168, Elsevier: Scopus) Yukikiyo Kawakami, Kazuya Kondo, Naoya Kawakita, Hisashi Matsuoka, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida and Akira Tangoku :
Long-term outcomes of sentinel node identification using indocyanine green in patients with lung cancer,
Thoracic Cancer, Vol.12, No.2, 165-171, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116983
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/1759-7714.13737
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33219734; ● Summary page in Scopus @ Elsevier: 2-s2.0-85096745669

(徳島大学機関リポジトリ: 116983, DOI: 10.1111/1759-7714.13737, PubMed: 33219734, Elsevier: Scopus) 鳥羽博明, 滝沢宏光, 青山万理子, 井上寛章, 丹黒章 :
より良いがんの地域連携体制構築のための包括的な取り組み,
日本臨床外科学会雑誌, Vol.82, No.7, 1281-1285, 2021年.

(要約): 目的:より良いがんの地域連携体制を構築するための包括的な取り組みについて紹介する．方法:かかりつけ医を対象に行った，がん患者の連携の可否と役割分担できる診療内容に関するアンケート結果をもとに，情報の可視化，新たな連携クリティカルパス(連携パス)の導入，拠点病院内の環境整備を行った．結果:まず，アンケート結果の情報を整理し，誰もがアクセスできるよう病院ホームページにアップして可視化した．さらに，予防的G-CSF(Granulocyte-Colony Stimulating Factor)投与連携パスを運用し，少数だが4例に適用した．加えて，入院中に医療ソーシャルワーカーが介入してかかりつけ医を決定し，文書作成を1分以内に完遂できる簡便な電子カルテ運用にして医師の作業負担を減らし，連携件数を約10倍増加させた．結語:より早期から緊密に情報交換し，役割分担することで，患者にとって満足度の高いがん医療を提供できる．今回の取り組みは，より良い連携体制構築に寄与すると考える．
(キーワード): がん患者の地域連携 / かかりつけ医 / 役割分担 / regional cooperation for cancer patients / community physician / division of roles
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.82.1281
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390572404756753792; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.82.1281

(DOI: 10.3919/jjsa.82.1281, CiNii: 1390572404756753792) Naoki Miyamoto, Seiya Inoue, Takeshi Nishino, Masakazu Goto, Takahiro Yoshida, Tomoko Kobayashi, Yoshimi Bando, Hiromitsu Takizawa and Akira Tangoku :
A CASE OF VAGUS NERVE SCHWANNOMA DIFFICULT TO DISTINGUISH FROM LYMPH NODAL METASTASIS OF ESOPHAGEAL CANCER.,
The Journal of Medical Investigation : JMI, Vol.68, No.1.2, 205-208, 2021.

(要約): In this report, we describe a rare case of vagus nerve schwannoma associated with esophageal cancer. A 70-year-old man visited our hospital complaining of worsening dysphagia. His upper gastrointenstinal endoscopy revealed a mass in the esophagus. A contrast-enhanced chest computed tomography also detected a 15 mm nodule attached to the tracheal membrane. This nodule was diagnosed as a metastatic lymph node. Although the primary tumor reduced after neoadjuvant chemotherapy, the nodule remained intact ; it showed fluorodeoxyglucose accumulation on positron emission tomography. We had a clinical diagnosis of stage III after neoadjuvant chemotherapy and underwent surgery. Intraoperatively, the nodule could not be detached from the right vagus nerve ; therefore, we excised the nodule along with the adjacent vagus nerve. The nodule was pathologically diagnosed as a vagus schwannoma. The nodule was not a regional lymph node metastasis of esophageal cancer. His postoperative course was uneventful, and he is currently undergoing outpatient follow-up without recurrence. J. Med. Invest. 68 : 205-208, February, 2021.
(徳島大学機関リポジトリ): ● Metadata: 116023
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.68.205
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33994473; ● Search Scopus @ Elsevier (PMID): 33994473; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.205

(徳島大学機関リポジトリ: 116023, DOI: 10.2152/jmi.68.205, PubMed: 33994473) 吉田光輝, 丹黒章, 東野恒作, 近藤和也, 岩田貴, 赤池雅史, 金山博臣, 鶴尾吉宏 :
【最先端医療を支える解剖学】呼吸器外科における最先端手術手技とCAL(Clinical Anatomy Laboratory),
四国医学雑誌, Vol.76, No.5-6, 225-234, 2020年.

(要約): Recently, endoscopic surgery is the most common procedurein the field of thoracic surgery. The newestthoracic surgeryapproaches are the video-assisted thoracic surgery(VATS), the one-port video-assisted thoracic surgery, and the robotic surgery. The individual advantages and disadvantages of these procedures have been discussed. VATS covers a field of view of the surgical field from the leg to the head. The basic method in performing VATS is that the surgeon operates on the abdominal area of the patient and the assistant expands the surgical field from the patient's back. It is currently the standard surgical procedure. The advantage of one-port VATS is the one port itself and its cosmetic advantages and pain reduction. The advantage of robotic surgery is that it has a clear three-dimensional enlarged field of view and can be performed using the delicate moving robotic arm. However, a good surgical training system should be established for the familiarization of these procedures. The clinical anatomy laboratory is the most efficient surgical training in addition to dry and wet lab training. Our institution has fresh-frozen cadavers, which are rare in Japan. The participating thoracic surgeons underwent training for VATS lobectomy, subxiphoid extended thymectomy, and pleurectomy decortication. This training is beneficial for educational and clinical purposes. In the future, we must obtain consistent surgical education before and after graduation using fresh-frozen cadavers. At the same time, a good organ model for training is also necessary. The surgeon has to cooperate with anatomy doctors for the development of a good surgical organ model. For the development of future surgical medicine, surgical training programs should be implemented.
(キーワード): thoracic surgery / fresh frozen cadaver / surgical training
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020840088219904

(CiNii: 1050020840088219904) 丹黒章, 鳥羽博明, 井上寛章, 笹聡一郎, 奥村和正, 青山万理子, 乾友浩, 滝沢宏光 :
Ⅲ. N-1 Study,
癌と化学療法, Vol.47, No.12, 1681-1686, 2020年.

(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33342983; ● Summary page in Scopus @ Elsevier: 2-s2.0-85098745716

(PubMed: 33342983, Elsevier: Scopus) M Yoshida, K Kondo, Naoko Matsui, Yuishin Izumi, Y Bando, M Yokoishi, K Kajiura and Akira Tangoku :
Prediction of improvement after extended thymectomy in non-thymomatous myasthenia gravis patients,
PLoS ONE, Vol.15, No.10, e0239756, 2020.

(要約): It is popularly believed that myasthenia gravis (MG) patients show acetylcholine receptor antibody (AChRAb) production associated with the thymus (germinal centers, approximately 80%). It has been suggested that thymectomy can remove the area of autoantibody production. This study aimed to determine whether the solid volume of the thymus calculated using three-dimensional (3D) imaging could be used to predict the efficacy of thymectomy. Additionally, the study assessed the relationships of the solid volume with germinal centers, change in the serum AChRAb level, postoperative MG improvement, and prednisolone (PSL) dose reduction extent. This retrospective study included 12 consecutive non-thymomatous MG patients (9 female and 3 male patients), who underwent extended thymectomy at our institution over the last 10 years. The mean patient age was 43.3 ± 14.2 years (range, 12-59 years). The study assessed the number of germinal centers per unit area, change in the serum AChRAb level, postoperative MG improvement, PSL dose reduction extent, and solid volume of the thymus. The number of germinal centers per unit area was significantly correlated with the solid volume of the thymus. The PSL dose reduction extent tended to be correlated with the solid volume. Our findings suggest that the solid volume of the thymus can possibly predict steroid dose reduction. Additionally, the solid volume of the thymus in 3D images is the most important indicator for predicting the efficacy of extended thymectomy.
(キーワード): Adult / Autoantibodies / Female / Humans / Male / Myasthenia Gravis / Receptors, Cholinergic / Retrospective Studies / Thymectomy / Thymoma / Thymus Neoplasms
(徳島大学機関リポジトリ): ● Metadata: 116622
(出版サイトへのリンク): ● Publication site (DOI): 10.1371/journal.pone.0239756
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33017427; ● Search Scopus @ Elsevier (PMID): 33017427; ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0239756

(徳島大学機関リポジトリ: 116622, DOI: 10.1371/journal.pone.0239756, PubMed: 33017427) Naoya Kawakita, Hiroaki Toba, Keiko Miyoshi, Shinichi Sakamoto, Daisuke Matsumoto, Mika Takashima, Mariko Aoyama, Seiya Inoue, Masami Morimoto, Takeshi Nishino, Hiromitsu Takizawa and Akira Tangoku :
Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration,
Stem Cell Research & Therapy, Vol.11, No.1, 430, 2020.

(要約): Bronchioalveolar stem cells (BASCs) located at the bronchioalveolar-duct junction (BADJ) are stem cells residing in alveoli and terminal bronchioles that can self-renew and differentiate into alveolar type (AT)-1 cells, AT-2 cells, club cells, and ciliated cells. Following terminal-bronchiole injury, BASCs increase in number and promote repair. However, whether BASCs can be differentiated from mouse-induced pluripotent stem cells (iPSCs) remains unreported, and the therapeutic potential of such cells is unclear. We therefore sought to differentiate BASCs from iPSCs and examine their potential for use in the treatment of epithelial injury in terminal bronchioles. BASCs were induced using a modified protocol for differentiating mouse iPSCs into AT-2 cells. Differentiated iPSCs were intratracheally transplanted into naphthalene-treated mice. The engraftment of BASCs into the BADJ and their subsequent ability to promote repair of injury to the airway epithelium were evaluated. Flow cytometric analysis revealed that BASCs represented ~ 7% of the cells obtained. Additionally, ultrastructural analysis of these iPSC-derived BASCs via transmission electron microscopy showed that the cells containing secretory granules harboured microvilli, as well as small and immature lamellar body-like structures. When the differentiated iPSCs were intratracheally transplanted in naphthalene-induced airway epithelium injury, transplanted BASCs were found to be engrafted in the BADJ epithelium and alveolar spaces for 14 days after transplantation and to maintain the BASC phenotype. Notably, repair of the terminal-bronchiole epithelium was markedly promoted after transplantation of the differentiated iPSCs. Mouse iPSCs could be differentiated in vitro into cells that display a similar phenotype to BASCs. Given that the differentiated iPSCs promoted epithelial repair in the mouse model of naphthalene-induced airway epithelium injury, this method may serve as a basis for the development of treatments for terminal-bronchiole/alveolar-region disorders.
(徳島大学機関リポジトリ): ● Metadata: 115515
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/s13287-020-01946-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33008488; ● Summary page in Scopus @ Elsevier: 2-s2.0-85092295153

(徳島大学機関リポジトリ: 115515, DOI: 10.1186/s13287-020-01946-7, PubMed: 33008488, Elsevier: Scopus) 笹聡一郎, 井上寛章, 奥村和正, 青山万理子, 乾友浩, 鳥羽博明, 吉田卓弘, 坂東良美, 丹黒章 :
腋窩副乳発生と考えられる若年性線維腺腫の1例,
四国医学雑誌, Vol.76, No.3,4, 185-190, 2020年.

(要約): A case is20years old woman. She had previously noticed a mass in the left axilla. The mass grew, so she went to the hospital. Ultrasonography revealed a 71 × 51 mm well-defined tumor in the left axilla. We suspected a benign tumor but could not rule out axillary lymph node metastasis or accessory breast cancer. The findings of fine needle aspiration cytology suggested fibroadenoma or phyllodes tumor. Although we diagnosed fibroadenoma by needle biopsy, a definitive diagnosis was made by tumor resection because it is located in the axilla and large in size, and other diseases such as phyllodes tumors can be distinguished. The histopathological diagnosis of the excised specimen was juvenile fibroadenoma. We report a case of juvenile fibroadenoma arising from the axillary accessory mammary gland.
(キーワード): Juvenile fibroadenoma / Axillary accessory mammary gland / Axillary tumor
(徳島大学機関リポジトリ): ● Metadata: 115366
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302315065218304

(徳島大学機関リポジトリ: 115366, CiNii: 1050302315065218304) Masami Morimoto, Hiroaki Toba, Mariko Aoyama, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida and Akira Tangoku :
Phase 1 Dose-Escalation Study of Triweekly Nab-Paclitaxel Combined With S-1 for HER2-Negative Metastatic Breast Cancer,
Clinical Breast Cancer, Vol.20, No.6, 448-453, 2020.

(要約): To evaluate the efficacy, toxicity, maximum tolerated dose, and recommended dose of triweekly nab-paclitaxel (nab-PTX) and S-1 combination chemotherapy for patients with metastatic breast cancer. This phase 1 study was conducted with a standard 3 + 3 dose escalation design. Every 3 weeks, the patients received nab-PTX at 180-260 mg/m on day 1 and S-1 at 65-80 mg/m daily on days 1 to 14. Ten HER2-negative metastatic breast cancer patients were enrolled; their median number of prior chemotherapy regimens was 3. Dose-limiting toxicity was observed in the first patient assigned to level 4; grade 4 febrile neutropenia and grade 3 neurotoxicity such as needing a wheelchair occurred. Therefore, an additional patient was not assigned to level 4. The maximum tolerated dose was considered level 4 (260 mg/m nab-PTX with 80 mg/m S-1). The recommended dose determined was level 3 (220 mg/m nab-PTX with 80 mg/m S-1). The response rate was 60.0%. The disease control rate was 70.0%. This combination chemotherapy therapy was feasible and safe for patients with HER2-negative metastatic breast cancer.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clbc.2020.07.012
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32800494; ● Summary page in Scopus @ Elsevier: 2-s2.0-85089357765

(DOI: 10.1016/j.clbc.2020.07.012, PubMed: 32800494, Elsevier: Scopus) Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Yoshihito Furukita, Yota Yamamoto, Satoshi Fujiwara, Takuya Minato, Hiroyuki Sumitomo, Yasuhiro Yuasa, Hiromitsu Takizawa and Akira Tangoku :
The sterno-tracheal distance is an important factor of anastomotic leakage of retrosternal gastric tube reconstruction after esophagectomy,
Esophagus, Vol.17, No.3, 264-269, 2020.

(要約): Anastomotic leakage (AL) is a serious complication after esophagectomy. The retrosternal (RS) route has been selected majorly to reduce reflux and related pneumonia and considering mediastinal recurrences. AL has been developed more in RS than posterior mediastinal (PM) route reconstruction. Therefore, we suspected the sterno-tracheal distance (STD) might be related to AL and started the selection according to the STD from 2009. A total of 221 patients who underwent a subtotal esophagectomy with gastric tube reconstruction during January 2004-April 2017 were investigated. The patients were classified into the 'after STD selection' (A; n = 144) group and the 'before STD selection' (B, n = 77) group. The incidences of and the risk factors for AL between the two groups were compared. The incidence of AL was high in the B group (18.2%), and 78.6% of the patients who developed AL were treated with RS route reconstruction. The median STDs of the patients with AL and no AL were 10.3 mm and 14.5 mm, respectively (p = 0.001). These results demonstrated that the STD was a risk factor for AL in the RS route. Based on these results, 13 mm was set as the cutoff value. After STD selection, the median STD increased from 14.0 to 17.3 mm (p = 0.001), and the incidence of AL decreased significantly from 26.2 to 11.1% in the RS route (p = 0.037). The STD was the independent risk factor for AL in the RS route. RS route reconstruction should be avoided for the patients with STD < 13 mm.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-019-00705-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31776810; ● Summary page in Scopus @ Elsevier: 2-s2.0-85075623295

(DOI: 10.1007/s10388-019-00705-9, PubMed: 31776810, Elsevier: Scopus) Daisuke Matsumoto, Hiroaki Toba, Kazuya Kondo and Akira Tangoku :
Thoracoscopic lobectomy for lung cancer with unilateral absence of pulmonary artery,
JTCVS Techniques, Vol.3, 343-345, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.xjtc.2020.06.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34317924; ● Search Scopus @ Elsevier (PMID): 34317924; ● Search Scopus @ Elsevier (DOI): 10.1016/j.xjtc.2020.06.024

(DOI: 10.1016/j.xjtc.2020.06.024, PubMed: 34317924) Naoki Miyamoto, Mitsuteru Yoshida, Mitsuhiro Tsuboi, Kenji Otsuka, Yoshimi Bando, Takumi Kakimoto, Naoya Kawakita, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
A case of long-term unchanged calcifying fibrous tumor,
General Thoracic and Cardiovascular Surgery, Vol.68, No.12, 1587-1590, 2020.

(要約): A calcifying fibrous tumor (CFT) is a rare benign tumor that may occur in any part of the body. We report the case of an asymptomatic 21-year-old woman with thoracic tumors. Chest computed tomography showed multiple masses in the left costophrenic angle. As we were unable to diagnose the tumor with a CT-guided needle biopsy, we performed a thoracoscopic biopsy. We found smooth multilobulated masses on the pleura and multiple small nodules around the main tumors. Partial resection of the tumor was performed by VATS. Histological examination revealed that the tumor had hypocellular fibrosclerotic tissue and distributed psammomatous calcifications with inflammatory infiltrates. Immunohistochemistry demonstrated that the spindle cells were partially positive for CD34 and CD99, but negative for anaplastic lymphoma kinase-1, smooth muscle actin, BCL-2, STAT6, and S-100 protein. The tumor was diagnosed as CFT. The patient's postoperative recovery was uneventful, and no progression of the lesions was observed during follow-up.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-020-01396-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32514881; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086121909

(DOI: 10.1007/s11748-020-01396-1, PubMed: 32514881, Elsevier: Scopus) 武知浩和, 森本雅美, 田代善彦, 松山和男, 宮内隆行, 石川正志, 笹聡一郎, 青山万理子, 井上聖也, 鳥羽博明, 吉田卓弘, 丹黒章 :
HER2陽性高齢者乳癌に対するAnthracycline系薬剤回避レジメンの忍容性と有効性についての検討,
四国医学雑誌, Vol.76, No.1,2, 69-72, 2020年.

(要約): Tolerability and efficacy of chemotherapy avoiding anthracycline regimen were examined histologically in ER negative and HER2positive elderly and poor risked breast cancer patients because of serious toxicity of Anthracycline regimen. Neo-adjuvant chemotherapy with 4 to 6 courses of Paclitaxel with Trastuzumab was given to 6 patients, Pertuzumab was added in 2 cases to obtain complete response. Adverse events were controllable, the primary treatment was completed without reducing the dose of drugs(RDI was 100%). Clinical CR rate was recognized in all 6 patients and pathological CR was proved in all of the operated5cases.
(キーワード): HER2 positive breast cancer / Elderly patients / Neo-adjuvant chemotherapy / RDI / pCR rate
(徳島大学機関リポジトリ): ● Metadata: 114858
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697875796224

(徳島大学機関リポジトリ: 114858, CiNii: 1050020697875796224) Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Hiromitsu Takizawa, Yoshimi Bando, Hideki Otsuka, Daisuke Matsumoto, Mika Takashima, Mitsuhiro Tsuboi, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Use of a prognostic risk score that aggregates the FDG-PET/CT SUVmax, tumor size, and histologic group for predicting the prognosis of pStage I lung adenocarcinoma,
International Journal of Clinical Oncology, Vol.25, No.6, 1079-1089, 2020.

(要約): pStage I includes clinicopathologically diverse groups. This study aimed to identify the prognostic factors for pStage I lung adenocarcinoma. We retrospectively reviewed 208 patients with pStage I adenocarcinomas who underwent curative resection in our institute between 2006 and 2013. The maximum standardized uptake value (SUVmax) on [F18]-fluoro-deoxy-D-glucose positron emission tomography-computed tomography (PET/CT) was evaluated. Adenocarcinomas were categorized into the following histologic groups: group 0 (minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma), group 1 (papillary predominant adenocarcinoma), and group 2 (acinar predominant adenocarcinoma and all the remaining subtypes). We assessed the relationship between disease-free survival (DFS) and clinicopathological factors. Multivariate analysis of DFS demonstrated that SUVmax > 3.0 (p < 0.001), total tumor size > 20 mm (p = 0.016), and histologic groups (p < 0.05) were independent prognostic factors. The prognostic risk score (PRS) was calculated using the following equation: PRS = SUVmax (≤ 3.0: 0 point, > 3.0: 2 points) + total tumor size (≤ 20 mm: 0 point, > 20 mm: 1 point) + histologic group (group 0: 0 point, group 1: 1 point, group 2: 2 points). Patients were divided into the following three risk groups: low-risk (PRS 0-2 points, n = 136), intermediate-risk (PRS 3-4 points, n = 49), and high-risk groups (PRS 5 points, n = 13). The 5-year DFS rates were 93.2%, 50.6%, and 30.8% for the low-, intermediate-, and high-risk groups, respectively (p < 0.001). The PRS aggregating the FDG-PET/CT SUVmax, total tumor size, and histologic group predicts the prognosis of pStage I lung adenocarcinoma.
(キーワード): Adenocarcinoma of Lung / Aged / Disease-Free Survival / Female / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Male / Middle Aged / Positron Emission Tomography Computed Tomography / Prognosis / Radiopharmaceuticals / Retrospective Studies / Risk Factors / Tumor Burden
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-020-01637-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32130543; ● Summary page in Scopus @ Elsevier: 2-s2.0-85081040433

(DOI: 10.1007/s10147-020-01637-6, PubMed: 32130543, Elsevier: Scopus) Mariko Aoyama, Hiromitsu Takizawa, Kiyoshige Yamamoto, Tomohiro INUI, Naoki Miyamoto, Shinichi Sakamoto, Tomoko Kobayashi, Hisanori Uehara and Akira Tangoku :
Effects of excitation light intensity on parathyroid autofluorescence with a novel near-infrared fluorescence imaging system : two surgical case reports,
Gland Surgery, Vol.9, No.5, 1584-1589, 2020.

(徳島大学機関リポジトリ): ● Metadata: 116330
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/gs-20-386
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.21037/gs-20-386

(徳島大学機関リポジトリ: 116330, DOI: 10.21037/gs-20-386) Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Kouhei Nishioka, Keisuke Fujimoto, Mariko Aoyama, Daisuke Matsumoto, Hiromitsu Takizawa and Akira Tangoku :
Safe central venous catheters for esophageal cancer treatment,
The Journal of Medical Investigation : JMI, Vol.67, No.3,4, 298-303, 2020.

(要約): Introduction : Central venous catheter (CVC) use is essential for treating esophageal cancer. Peripherally inserted central catheters (PICC) are commonly used recently for improved patient comfort and safety. We compared centrally inserted central catheters (CICC) and PICC insertions and examined their safety. Methods : We retrospectively investigated complications at the catheter insertion and post-insertion for 199 patients' esophageal cancer treatment (CICC : 45, PICC : 154) from 2013 to 2018. In addition, we summarized the results of catheter tip culture. Results : No serious complications occurred at the catheter insertion in either group. The rate of complications at catheter insertion was 5.8% for PICC and 6.7% for CICC patients. Post-insertion complications were observed in 6.5% and 11.1% of patients with PICC and CICC, respectively, and this difference was not significant. The incidence of catheter-related blood stream infection (CRBSI) was significantly lower in PICC than CICC patients (0.3 vs. 1.8 / 1,000 catheter-days ; p = 0.029). Catheter-related thrombosis was observed in PICC : 0.5 and CICC : 0.6, and occlusion due to blood flow reversal was observed in PICC : 0.5 and CICC : 0.6. Conclusion : PICCs are safer and more effective than CICCs for the treatment of esophageal cancer, and reduce the incidence of CRBSI. We hope to standardize the insertion procedures, conventionalize techniques, and establish training systems. J. Med. Invest. 67 : 298-303, August, 2020.
(徳島大学機関リポジトリ): ● Metadata: 115428
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.67.298
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148905; ● Summary page in Scopus @ Elsevier: 2-s2.0-85095590219

(徳島大学機関リポジトリ: 115428, DOI: 10.2152/jmi.67.298, PubMed: 33148905, Elsevier: Scopus) Mariko Aoyama, Hiromitsu Takizawa, Tamaki Otani, Seiya Inoue, Naoya Kawakita, Mitsuhiro Tsuboi, Yoshimi Bando, Hisanori Uehara, Kazuya Kondo and Akira Tangoku :
Noninvasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using smallanimal FDGPET/CT,
Oncology Reports, Vol.44, 1709-1716, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115331
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2020.7720
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3892/or.2020.7720

(徳島大学機関リポジトリ: 115331, DOI: 10.3892/or.2020.7720) 坪井光弘, 青山万理子, 滝沢宏光, 吉田光輝, 岩田貴, 赤池雅史, 金山博臣, 鶴尾吉宏, 丹黒章 :
内視鏡手術の教育システム,
日本内分泌・甲状腺外科学会雑誌, Vol.37, No.1, 22-26, 2020年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11226/jaesjsts.37.1_22
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390848250117531136; ● Search Scopus @ Elsevier (DOI): 10.11226/jaesjsts.37.1_22

(DOI: 10.11226/jaesjsts.37.1_22, CiNii: 1390848250117531136) Reina Kishibuchi, Kazuya Kondo, Shiho Soejima, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma,
International Journal of Oncology, Vol.56, No.1, 315-326, 2019.

(要約): Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non-synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterations in these types of cancer. In this study, we thus performed genome-wide screening of aberrantly methylated CpG islands in thymoma and thymic carcinoma using Illumina HumanMethylation450 K BeadChip. We identified 92 CpG islands significantly hypermethylated in thymic carcinoma in relation to thymoma and selected G protein subunit gamma 4 (GNG4), growth hormone secretagogue receptor (GHSR), homeobox D9 (HOXD9) and spalt like transcription factor 3 (SALL3), which are related to cancer. We examined the promoter methylation of 4 genes in 46 thymic epithelial tumors and 20 paired thymus tissues using bisulfite pyrosequencing. Promoter methylation was significantly higher in thymic carcinoma than in thymoma and revealed a high discrimination between thymic carcinoma and thymoma in all 4 genes. Promoter methylation was higher in thymic carcinoma than in the thymus. No significant differences were observed in the promoter methylation of GNG4, HOXD9, or SALL3 between thymoma and the thymus. The promoter methylation of the 4 genes was not significantly higher in advanced-stage tumors than in early-stage tumors in all thymic epithelial tumors. Among the 4 genes, relapse-free survival was significantly worse in tumors with a higher DNA methylation than in those with a lower DNA methylation in all thymic epithelial tumors. Moreover, relapse-free survival was significantly worse in thymomas with a higher DNA methylation of HOXD9 and SALL3 than in those with a lower DNA methylation. On the whole, the findings of this study indicated that the promoter methylation of cancer-related genes was significantly higher in thymic carcinoma than in thymoma and the thymus. This is a common epigenetic alteration of high diagnostic value in thymic carcinoma and may be involved in the carcinogenesis of thymic carcinoma. However, epigenetic alterations in the 3 genes, apart from GHSR, are not involved in the tumorigenesis of thymoma.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2019.4915
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31746370; ● Summary page in Scopus @ Elsevier: 2-s2.0-85076979892

(DOI: 10.3892/ijo.2019.4915, PubMed: 31746370, Elsevier: Scopus) Mitsuhiro Tsuboi, Kazuya Kondo, Shiho Soejima, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
Chromate exposure induces DNA hypermethylation of the mismatch repair gene MLH1 in lung cancer,
Molecular Carcinogenesis, Vol.59, No.1, 24-31, 2019.

(要約): Hexavalent chromium is recognized as a human carcinogen. Our previous studies revealed that lung cancer (LC) in chromate-exposed workers (chromate LC) had molecular features of frequent microsatellite instability (MSI), repression of MLH1 level, and aberrant DNA methylation of several tumor-suppressor genes, including MLH1. In the present study, we quantitatively investigated MLH1-promoter methylation status using bisulfite pyrosequencing of paired tumorous/nontumorous tissues from chromate and nonchromate LCs to determine the effect of chromate exposure on MLH1-promoter methylation. The methylation level of MLH1 promoter was significantly higher in chromate LC tumors (P < .001) than nonchromate LC tumors and, among chromate LC, significantly higher in tumorous tissue than nontumorous tissue (P = .004). Moreover, the methylation level of MLH1 promoter in normal lung tissue tended to be higher in chromate LC than nonchromate LC (P = .062). In addition, LC with reduced levels of MLH1 showed significantly higher methylation levels of MLH1 promoter than LC exhibiting normal MLH1 levels (P = .019). Moreover, immunohistochemical analyses determined that levels of SUV39H1, an H3K9me2-related methyltransferase, were higher in chromate LC than nonchromate LC (P = .076). Furthermore, we evaluated three DNA double-strand break-repair genes (MRE11, RAD50, and DNA-PKcs) as possible targets of MSI by fragment-length polymorphism analysis, revealing the mutation frequency of RAD50 as significantly higher in chromate LC than nonchromate LC (P = .047). These results suggest that chromate exposure might induce MLH1 hypermethylation in LC as a mechanism of chromate-induced carcinogenesis.
(キーワード): Aged / Carcinogenesis / Chromates / DNA Methylation / DNA Mismatch Repair / Humans / Lung Neoplasms / Microsatellite Instability / Middle Aged / MutL Protein Homolog 1 / Promoter Regions, Genetic
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mc.23125
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31579968; ● Search Scopus @ Elsevier (PMID): 31579968; ● Search Scopus @ Elsevier (DOI): 10.1002/mc.23125

(DOI: 10.1002/mc.23125, PubMed: 31579968) Takumi Sakurada, Sanako Bando, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Mitsuhiro Goda, Yasushi Kirino, Toshimi Nakamura, Kazuhiko Teraoka, Masami Morimoto, Akira Tangoku and Keisuke Ishizawa :
Prophylactic administration of granulocyte colony-stimulating factor in epirubicin and cyclophosphamide chemotherapy for Japanese breast cancer patients: a retrospective study.,
Cancer Chemotherapy and Pharmacology, Vol.84, No.5, 1107-1114, 2019.

(要約): The incidence rate of FN was 23.9%. In patients who received G-CSF as primary prophylaxis, FN expression was completely suppressed. The incidence rate of severe leucopenia/neutropenia, emergency hospitalization, and the use of antimicrobial agents were low in patients receiving primary prophylaxis with G-CSF compared with those not receiving G-CSF (27.3% vs. 64.8%, 9.1% vs. 27.3%, and 27.3% vs. 71.6%, respectively). Furthermore, in all patients who received primary prophylaxis with G-CSF, a relative dose intensity > 85% using EC therapy was maintained.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00280-019-03948-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31502114; ● Search Scopus @ Elsevier (PMID): 31502114; ● Search Scopus @ Elsevier (DOI): 10.1007/s00280-019-03948-6

(DOI: 10.1007/s00280-019-03948-6, PubMed: 31502114) Mitsuhiro Tsuboi, Kazuya Kondo, Kiyoshi Masuda, Shoichiro Tange, Koichiro Kajiura, Tomohiro Kohmoto, Hiromitsu Takizawa, Issei Imoto and Akira Tangoku :
Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma,
Cancer Medicine, Vol.8, No.9, 4189-4199, 2019.

(要約): In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with LADC. GAD1 methylation and mRNA expression status were analyzed using 33 tumorous and paired non-tumorous LADC samples and publicly available datasets. The prognostic value of GAD1 overexpression was investigated using publicly available datasets of mRNA levels and 162 cases of LADC by immunohistochemistry. The methylation and mRNA expression levels of GAD1, each having a positive correlation, were significantly higher in LADC tumors than in paired non-tumorous tissues. LADC patients with higher GAD1 mRNA expression showed significantly poorer prognosis for overall survival in publicly available datasets. Higher immunoreactivity of GAD1 was significantly associated with the pathological stage, pleural invasion, lymph vessel invasion, and poorer prognosis for cancer-specific and disease-free survival. Multivariate analysis revealed that GAD1 protein overexpression is an independent prognosticator for disease-free survival. GAD1 mRNA and protein expression levels were significant prognostic factors in LADC, suggesting that they might be useful biomarkers to stratify patients with worse clinical outcomes after resection.
(徳島大学機関リポジトリ): ● Metadata: 113692
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.2345
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31207151; ● Summary page in Scopus @ Elsevier: 2-s2.0-85071059073

(徳島大学機関リポジトリ: 113692, DOI: 10.1002/cam4.2345, PubMed: 31207151, Elsevier: Scopus) A.A.Ali Eman, Hiromitsu Takizawa, Naoya Kawakita, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mika Takashima, Daisuke Matsumoto, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo, El-Badrawy Khairy Mohammad and Akira Tangoku :
Transbronchial Biopsy Using an Ultrathin Bronchoscope Guided by Cone-Beam Computed Tomography and Virtual Bronchoscopic Navigation in the Diagnosis of Pulmonary Nodules,
Respiration, Vol.98, No.4, 321-328, 2019.

(要約): Transbronchial biopsy is a safe diagnostic approach for patients with peripheral pulmonary lesions; however, the diagnostic yield is low. This study was conducted to evaluate the feasibility and diagnostic yield of transbronchial biopsy using the combination of an ultrathin bronchoscope, virtual bronchoscopic navigation (VBN), and cone-beam computed tomography (CBCT). Patients with peripheral pulmonary lesions, no >30 mm, with the responsible bronchus, were prospectively included. An ultrathin bronchoscope and biopsy forceps were advanced to the target bronchus under VBN, 2D-fluoroscopy, and CBCT. We categorized the CBCT findings before biopsy into 3 types according to positions of the target lesion and forceps (CBCT target-forceps sign). In type A, the forceps reached the inside of the target lesion. In type C, the forceps could not reach the lesion. When the CBCT findings could not be categorized into either type A or C, the sign was categorized as type B. Although the target lesions were invisible by conventional C-arm fluoroscopy in 29 patients, CBCT visualized all 40 lesions. The overall diagnostic yield was 90.0%, and diagnostic yields for malignant and benign lesions were 92.0 and 86.7%, respectively. Diagnostic yields for CBCT target-forceps sign types A, B, and C were 100, 75.0, and 0%, respectively. Four undiagnosed patients proceeded to other diagnostic procedures based on the CBCT target-forceps sign (type B: n = 2, type C: n = 2) and were correctly diagnosed without delay. Transbronchial biopsy using an ultrathin bronchoscope guided by CBCT and VBN showed a very high yield in the diagnosis of pulmonary nodules.
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000500228
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31121593; ● Search Scopus @ Elsevier (PMID): 31121593; ● Search Scopus @ Elsevier (DOI): 10.1159/000500228

(DOI: 10.1159/000500228, PubMed: 31121593) 鳥羽博明, 滝沢宏光, 吉田卓弘, 森本雅美, 青山万理子, 西口京子, 宮越智寿, 武知浩和, 丹黒章 :
がんの地域連携かかりつけ医との役割分担に関するアンケート調査,
四国医学雑誌, Vol.75, No.1,2, 49-54, 2019年.

(要約): It was suggested long ago that regional cooperation is necessary for cancer patients. Both doctors in base hospitals and community doctors understand the importance of such cooperation. Here we report the results of our widely distributed questionnaire designed to clarify the division of physicians' roles and to strengthen the relationships between base hospital and community doctors. The questionnaire asks whether community doctors can accept cancer patients and what types of medical treatment the doctors can provide for patients with esophageal cancer, lung cancer, breast cancer, and thyroid cancer. The doctors in 289 of 550 (53%) facilities completed and returned the questionnaire. About half of the community doctors responded that they can accept patients with any of the four cancers and can provide most types of the necessary medical examinations and treatments in their daily practices. Most of the community doctors indicated that they could not provide some anti-cancer drugs and supportive drug therapies for breast cancer patients. The development and implementation of a clinical pathway system could enable the participation of more community doctors and base hospital doctors. Although our findings are preliminary, they will contribute to a foundation for building better regional corporative relationships with community doctors who treat cancer patients.
(キーワード): A widely distributed questionnaire / Regional corporation / Cancer patient / Community Doctor
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050583647829621248

(CiNii: 1050583647829621248) Naoya Kawakita, Hiromitsu Takizawa, Toru Sawada, Daisuke Matsumoto, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Indocyanine green fluorescence imaging for resection of pulmonary metastasis of hepatocellular carcinoma,
Journal of Thoracic Disease, Vol.11, No.3, 944-949, 2019.

(要約): Indocyanine green (ICG) accumulates in hepatocellular carcinoma (HCC), and tumor fluorescence can be observed under irradiation with near infrared light (NIR). This study investigated the clinical utility of ICG fluorescence imaging during resection of pulmonary metastases of HCC. From April 2010 to June 2018, six patients with suspected pulmonary metastasis of HCC were enrolled prospectively. Prior to surgery, all patients underwent the ICG hepatic function test following intravenous administration of ICG (0.5 mg/kg body weight). During surgery, metastatic HCC was identified by observation of ICG fluorescence, allowing assessment of the surgical margin. Tumor fluorescence was also evaluated on cut sections. A total of 11 metastatic HCCs were resected in six patients at nine operations. Eight lesions were removed by wedge resection and 3 lesions were managed by lobectomy. During surgery, tumor fluorescence could be confirmed through the visceral pleura in 6 out of 7 lesions treated by wedge resection, while NIR irradiation was difficult for 1 lesion. For these 6 lesions, the median distance from the tumor to the visceral pleura and the median surgical margin were 0 mm (range, 0-2 mm) and 14 mm (range, 11-17 mm), respectively. When cut sections were examined, all tumors emitted fluorescence. All lesions were histologically confirmed to be metastatic HCC. In patients with pulmonary metastasis of HCC, ICG fluorescence imaging is useful for identifying the tumor and securing its margin when the lesion is peripheral and wedge resection is planned.
(徳島大学機関リポジトリ): ● Metadata: 116459
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd.2019.01.107
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31019784; ● Search Scopus @ Elsevier (PMID): 31019784; ● Search Scopus @ Elsevier (DOI): 10.21037/jtd.2019.01.107

(徳島大学機関リポジトリ: 116459, DOI: 10.21037/jtd.2019.01.107, PubMed: 31019784) Koichiro Kajiura, Shoichiro Takao, Kawano Naoko, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku and Kazuya Kondo :
Evaluation of the components of mediastinal cystic lesions using imaging techniques,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 106-111, 2019.

(要約): To identify and differentiate patients with mediastinal cysts from those with cystic tumors requiring surgery. A total of 36 patients with mediastinal cystic lesions were enrolled. The patients were separated into two groups based on pathological findings : those with mediastinal cysts (n=23) and those with mediastinal tumors (n=13). The cystic components were measured using imaging parameters including mean computed tomography (CT) value, apparent diffusion coefficient (ADC), T1 signal intensity ratio (T1SIratio), and T2 signal intensity ratio (T2SI-ratio), acquired from magnetic resonance imaging (MRI) ; and standardized maximum uptake value (SUVmax) fromF-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT). Both groups were statistically compared. Comparative parameters between the cysts and tumors revealed the following ratios : CT value, 40.9?21.2 versus (vs) 24.8?12.9 (p = 0.019) ;SUVmax, 1.18?0.50 vs 4.32?3.52 (p = 0.003) ; ADC, 3.46?0.96 vs 2.68?0.74 (p = 0.022) ; T1SI-ratio, 1.06?0.60 vs 1.35? 0.92 (p = 0.648) ; T2SI-ratio, 5.40?1.80 vs 4.33?1.58 (p = 0.194). However, there was no correlation between FDG uptake and ADC value. SUVmax fromF-FDG PET/CT and ADC derived from MRI were effective in facilitating preoperative diagnosis to differentiate mediastinal cysts from tumors. However, these examinations may be complementary to one another, not dominant. J. Med. Invest. 66 : 106-111, February, 2019.
(キーワード): Adult / Aged / Aged, 80 and over / Cysts / 女性 (female) / Fluorodeoxyglucose F18 / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / 男性 (male) / Mediastinal Diseases / Mediastinal Neoplasms / Middle Aged / Positron Emission Tomography Computed Tomography
(徳島大学機関リポジトリ): ● Metadata: 113404
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064920; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065786369

(徳島大学機関リポジトリ: 113404, DOI: 10.2152/jmi.66.106, PubMed: 31064920, Elsevier: Scopus) Chisato Tonoiso, Hitoshi Ikushima, Akiko Kubo, Takashi Kawanaka, Shunsuke Furutani, Takaharu Kudoh, Takahiro Yoshida, Hiroshi Miyamoto, Masafumi Harada, Tetsuji Takayama and Akira Tangoku :
Clinical outcomes and prognostic factors of definitive radiotherapy for esophageal cancer,
The Journal of Medical Investigation : JMI, Vol.66, No.1, 2, 99-105, 2019.

(要約): Purpose To assess the treatment results of definitive radiotherapy for esophageal cancer at Tokushima University Hospital and clarify the prognostic factors. Methods Seventy consecutive patients with esophageal cancer who underwent definitive radiotherapy between May 2004 and March 2012 were included in the present study. Local control rate, overall survival rate, and radiation morbidity were examined and univariate and multivariate analyses were performed to investigate prognostic factors. Results The 5-yearoverall survival rates of stages I, II, III, and IVA were 81%, 71%, 0%, and 9%, respectively. Performance status, clinical stage, and neoadjuvant chemotherapy were significant prognostic factors. A past history of interstitial pneumonia was associated with severe radiation-induced lung injury. Conclusions Patients who underwent definitive chemoradiotherapy for esophageal cancer in stage I/II showed good prognosis. However, treatment results of the patients in stage III/IV were not satisfactory, and those who could not undergo surgery after neoadjuvant chemotherapy had the worst prognosis.J.Med.Invest.66:99-105, February, 2019.
(キーワード): esophageal cancer / radiotherapy / chemoradiotherapy
(徳島大学機関リポジトリ): ● Metadata: 113342
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.99
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064964; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065782310

(徳島大学機関リポジトリ: 113342, DOI: 10.2152/jmi.66.99, PubMed: 31064964, Elsevier: Scopus) Misako Nakagawa, Mayumi Ikeuchi, Masami Morimoto, Hirokazu Takechi, Hiroaki Toba, Takahiro Yoshida, Kazumasa Okumura, Naoki Hino, Aya Nishisho and Akira Tangoku :
Phase II Study of S-1 Combined With Low-Dose Docetaxel as Neoadjuvant Chemotherapy for Operable Breast Cancer Patients (N-1 Study),
Clinical Breast Cancer, Vol.S1526-8209, No.18, 30262-30263, 2019.

(要約): To improve the pathological complete response (pCR) rate, we devised new neoadjuvant chemotherapy. Efficacy and safety of the oral fluoropyrimidine derivative S-1 (Taiho Pharmaceutical Co, Tokyo, Japan) combined with low-dose docetaxel (S-1+DOC) were evaluated. Patients were treated with docetaxel (40 mg/m intravenously on day 1) and S-1 (40 mg/m orally twice per day on days 1-14) every 3 weeks for 4 cycles. In accord with the Response Evaluation Criteria In Solid Tumors version 1.1 criteria, the patients who showed a complete response (CR) underwent surgery, and those who achieved a partial response (PR) underwent 4 more cycles of S-1+DOC. Patients who achieved stable disease (SD) or progressive disease (PD) received EC (epirubicin and cyclophosphamide) or HT (trastuzumab and paclitaxel) according to their HER2 status. The primary end point was the pCR rate. Ninety-four patients entered the study. After 4 cycles of S-1+DOC, CR was noted in 5 patients, PR in 57, SD in 18, and PD in 3. Of the patients who achieved SD and PD, 12 received EC, and 9 received HT. Among the 83 assessable patients, the pCR rate was 34.9%, and the response rate was 80.7%. The pCR rates were 19.5% in the luminal type group, 53.8% in the luminal HER2 group, 46.1% in the HER2 group, and 50.0% in the triple-negative group. The S-1+DOC regimen in this study could be well tolerated and a new candidate neoadjuvant chemotherapy in operable breast cancer patients. It is also expected to be effective even in patients with luminal type disease. However, further randomized control trials are needed to ascertain whether pCR can contribute to favorable outcomes.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.clbc.2018.09.008
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30340871; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054791101

(DOI: 10.1016/j.clbc.2018.09.008, PubMed: 30340871, Elsevier: Scopus) Naoya Kawakita, Hiroaki Toba, Shoji Sakiyama, Mitsuhiro Tsuboi, Hiromitsu Takizawa and Akira Tangoku :
A case of thoracoscopic medial basal segmentectomy,
International Journal of Surgery Case Reports, Vol.55, 15-17, 2019.

(要約): Isolated resection of the medial basal segment (S7) is uncommon because of its small volume, and S7 segmentectomy is considered to be difficult due to anatomical variation. We report a case of successful thoracoscopic S7 segmentectomy. A 56-year-old man was referred to our hospital with suspected pulmonary metastasis of rectal cancer. A 6-mm nodule was detected in S7. A7 and B7 branched from the basal segmental artery and bronchus, respectively, to run ventral to the inferior pulmonary vein. This made it possible to isolate A7 and B7 by an approach via the interlobar fissure. In addition, V7a and V7b were easily isolated from inferior pulmonary vein. The intersegmental plane was indicated by V7b and was transected along a demarcation line identified by using selective oxygenation via B7. B7 most commonly branches from the basal bronchus and A7 from the basal artery to run ventral to the inferior pulmonary vein. With this anatomical type, when the surgeon approaches via the interlobar fissure during surgery, A7 is identified first, B7 is seen behind A7, and the IPV is posterior to B7. Since the intersegmental plane is located ventral to the IPV, segmentectomy can be completed via the interlobar fissure approach. In patients with this pattern of pulmonary artery and bronchial anatomy, isolated S7 segmentectomy is a feasible treatment option.
(徳島大学機関リポジトリ): ● Metadata: 115161
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijscr.2018.12.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30660053; ● Summary page in Scopus @ Elsevier: 2-s2.0-85059933507

(徳島大学機関リポジトリ: 115161, DOI: 10.1016/j.ijscr.2018.12.004, PubMed: 30660053, Elsevier: Scopus) 丹黒章, 吉田卓弘, 鳥羽博明, 武知浩和, 奥村和正, 西野豪志, 井上聖也, 中川美砂子, 森本雅美, 澤田徹, 青山万理子, 宮本直輝, 西岡康平, 藤本啓介, 滝沢宏光 :
CT lymphography for superficial esophageal cancer. Lymph Node Metastasis in Gastrointestinal Cancer" Part IV. Sentinel node navigation surgery, Chapter 17, Methodology: CT lumphography,
Lymph Node Metastasis in Gastrointestinal Cancer. Ed. By Natsugoe S, Springer-Verlag, Tokyo, 323-333, 2019年.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/978-981-10-4699-5_17
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1007/978-981-10-4699-5_17

(DOI: 10.1007/978-981-10-4699-5_17) 森本雅美, 中川美砂子, 武知浩和, 阿部彰子, 大津雅信, 宮本容子, 吉田友紀子, 桑原章, 井本逸勢, 丹黒章 :
Li-Fraumeni syndromeと診断された若年発症両側多発乳癌の1例,
乳癌の臨床, Vol.34, No.2, 165-170, 2019年. Haruka Takasugi, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto, Seiya Inoue, Daisuke Matsumoto, Tomohiro Inui, Hiromitsu Takizawa, Hideo Tsuzuki, Toshikatsu Taniki and Akira Tangoku :
Acase of advanced colon cancer arising from a colonic graft foran esophago-bronchial fistula : A case report.,
The Journal of Medical Investigation : JMI, Vol.66, No.1.2, 190-193, 2019.

(要約): Neoplasm of a colonic graft after esophageal reconstruction is rare. We treated a colon cancer patient who developed malignancy in a colonic graft after esophagectomy and reconstruction through a retrosternal route. A male had undergone esophagectomy in his 50s due to a benign esophago-bronchial fistula. His dysphagia became exacerbated 20 years later, and further examinations showed a circumferential tumor on the esophagocolonic anastomosis. He underwent resection of the colonic graft adenocarcinoma with median sternotomy after neoadjuvant chemotherapy. Gastric tube reconstruction was performed through a retrosternal route. This report should be informative in terms of making decisions from an initial reconstruction to follow-up and choosing a therapeutic strategy for colonic graft cancer in the future. J. Med. Invest. 66 : 190-193, February, 2019.
(徳島大学機関リポジトリ): ● Metadata: 113422
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.190
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064939; ● Search Scopus @ Elsevier (PMID): 31064939; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.190

(徳島大学機関リポジトリ: 113422, DOI: 10.2152/jmi.66.190, PubMed: 31064939) Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Shinichi Yamasaki, Yoshihiro Tsuruo and Akira Tangoku :
Surgical training in video-assisted neck surgery-based thyroidectomy using fresh frozen human cadavers.,
The Journal of Medical Investigation : JMI, Vol.66, No.3.4, 293-296, 2019.

(要約): Endoscopic surgery has been introduced in various surgical fields. Endoscopic surgery requires different skills from open surgery due to the restricted surgical field and difficulty in identifying anatomical structures from certain viewpoints. Therefore, surgeons need to undergo sufficient surgical training before performing such surgery in the clinical setting. We examined the utility of fresh frozen human cadavers for surgical training aimed at introducing video-assisted neck surgery (VANS) at our department. First, we performed surgical training using fresh human cadavers four times. Next, we performed hemi-thyroidectomy with VANS in 5 clinical patients. After the cadaver training and the actual surgery, the surgeons evaluated each step of the surgical procedure using a 3-point scale. In the cadaver training, the scores for steps : creation of a subcutaneous tunnel and lifting up the skin flap and pre-thyroid muscles were higher than other steps. And a tracheal injury occurred as a complication. However, we were able to recognize anatomical structures under the endoscopic view. And it was also useful for confirming the role of surgical staff and simulating the placement of surgical equipment. Surgical training using fresh frozen human cadavers was effective at introducing a new surgical method. J. Med. Invest. 66 : 293-296, August, 2019.
(徳島大学機関リポジトリ): ● Metadata: 114082
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.293
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656292; ● Summary page in Scopus @ Elsevier: 2-s2.0-85074148764

(徳島大学機関リポジトリ: 114082, DOI: 10.2152/jmi.66.293, PubMed: 31656292, Elsevier: Scopus) 森本雅美, 行重佐和香, 池内真由美, 中川美砂子, 武知浩和, 鳥羽博明, 丹黒章 :
乳癌頚椎転移による脊髄麻痺に対して迅速な集学的治療によりQOLの改善が得られた1例,
四国医学雑誌, Vol.74, No.3,4, 119-124, 2018年.

(要約): A 60s female complained of right thigh pain caused by bone metastasis from advanced breast cancer. She was introduced to our ward for systemic therapy with palliative radiation to painful osteolytic lesion in the right femur. She suddenly complained of serious pain and motility disturbance in the right upper-extremity two days after her admission. Magnetic resonance imaging(MRI)suggested bone metastasis in the 3rd cervical vertebra which compressed spinal cord. We discussed about an optimal treatment with the orthopedic surgeon and the radiation therapeutic physician, and laminectomy was scheduled promptly. She also had a right femur fracture a day before her planed laminectomy, so she underwent osteosynthesis of the femur together with laminectomy of the cervical vertebra. She also received the irradiation to the 3rd cervical vertebra and the shaft of right femur. She became able to eat with a spoon by herself and her activity of daily living(ADL)have fully recovered by daily rehabilitation. She is receiving chemotherapy in our out-patient clinic now. We recognized that an emergent oncological treatment for the spinal decompression by the bone metastasis could improve the patients' quality of life(QOL)to avoid the permanent paralysis and also their prognoses.
(キーワード): spinal decompression / 乳癌 (breast cancer) / 骨転移 (bone metastasis)
(徳島大学機関リポジトリ): ● Metadata: 112301
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050583647830117888

(徳島大学機関リポジトリ: 112301, CiNii: 1050583647830117888) Satomi Moriyama, Daisuke Hinode, Masami Yoshioka, Yuka Sogawa, Takeshi Nishino, Akira Tangoku and Daniel Grenier :
Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy: a clinical trial for oral hygiene and oral condition,
The Journal of Medical Investigation : JMI, Vol.65, No.3,4, 184-190, 2018.

(要約): The aim of this study was to investigate the impact of the use of two Kampo medicines on oral mucositis, tongue coating bacteria, and gingiva condition in patients with esophageal cancer undergoing chemotherapy. Twenty-three esophageal cancer patients who receive chemotherapy at Tokushima University Hospital, were included. The participants, who received professional oral healthcare, were randomly divided into three groups:7 subjects received Daiokanzoto sherbets, 7 subjects received Hangeshashinto sherbets, and 9 subjects received nothing (control). The numbers of total bacteria and specific periodontopathogenic bacteria in tongue coating were determined in addition to clinical parameters. No difference on the onset of oral mucositis was found among the three groups. However, tongue coating index, gingival index (GI), plaque index, the number of total bacteria, Fusobacterium nucleatum and Campylobacter rectus were decreased during chemotherapy. More specifically, GI as well as the number of F. nucleatum and C. rectus were decreased significantly in the Daiokanzoto group when compared to the control group (psize 8 < 0.05). No such differences were observed for the group receiving Hangeshashinto. This clinical trial showed that Daiokanzoto might be effective in attenuating gingival inflammation and reducing the levels of periodontopathogenic bacteria in patients with esophageal cancer. J. Med. Invest. 65:184-190, August, 2018.
(キーワード): Aged / Antineoplastic Agents / Bacterial Load / Campylobacter rectus / Drugs, Chinese Herbal / Esophageal Neoplasms / Female / Fusobacterium nucleatum / Gingivitis / Humans / Male / Medicine, Kampo / Middle Aged / Oral Hygiene / Periodontal Index / Plant Extracts / Stomatitis
(徳島大学機関リポジトリ): ● Metadata: 112235
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.184
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30282858; ● Summary page in Scopus @ Elsevier: 2-s2.0-85054441144

(徳島大学機関リポジトリ: 112235, DOI: 10.2152/jmi.65.184, PubMed: 30282858, Elsevier: Scopus) Mitsuhiro Tsuboi, Hiromitsu Takizawa, Takahiro Yoshida and Akira Tangoku :
Mediastinal Parathyroidectomy Using a Cervical Approach Under a Pneumomediastinum,
Seminars in Thoracic and Cardiovascular Surgery, Vol.30, No.4, 472-474, 2018.

(要約): Video-assisted thoracoscopic surgery (VATS) and robotic surgery are minimally invasive surgeries for mediastinal parathyroid adenomas. However, a transthoracic approach is often difficult in the cervicothoracic transition area because of the limited visual field. We report a novel minimally invasive surgery for an ectopic parathyroid adenoma in the middle mediastinum using a cervical approach under a pneumomediastinum.
(キーワード): Adenoma / Aged, 80 and over / Choristoma / 女性 (female) / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Mediastinal Neoplasms / Minimally Invasive Surgical Procedures / Parathyroid Glands / Parathyroid Neoplasms / Parathyroidectomy / Pneumomediastinum, Diagnostic / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1053/j.semtcvs.2018.07.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30031948; ● Summary page in Scopus @ Elsevier: 2-s2.0-85051070531

(DOI: 10.1053/j.semtcvs.2018.07.007, PubMed: 30031948, Elsevier: Scopus) Mitsuhiro Tsuboi, Hiromitsu Takizawa, Takahiro Yoshida and Akira Tangoku :
Mediastinal Parathyroidectomy Using a Cervical Approach Under a Pneumomediastinum.,
Seminars in Thoracic and Cardiovascular Surgery, Vol.S1043, No.19, 121-127, 2018.

(出版サイトへのリンク): ● Publication site (DOI): 10.1053/j.semtcvs.2018.07.007
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30031948; ● Summary page in Scopus @ Elsevier: 2-s2.0-85051070531

(DOI: 10.1053/j.semtcvs.2018.07.007, PubMed: 30031948, Elsevier: Scopus) 河北直也, 鳥羽博明, 先山正二, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
選択的肺葉ブロックを用いた肺切除の2例,
四国医学雑誌, Vol.74, No.1,2, 55-60, 2018年.

(要約): There are cases in which one-lung ventilation is difficult due to contralateral lung resection or low lung function. Selective lobar blockade can improve oxygenation compared with one-lung ventilation and secure a good operative field by inducing partial collapse. We report two cases of lung resection involving selective lobar blockade. (Case1) An 80-year-old female had previously undergone right upper and middle lobectomy for multiple lung tumors. Surgery was scheduled to remove a 7‐mm ground glass opacity from the upper left lobe. Oral intubation was performed (inner diameter of intubation tube:8mm). Next, the left upper lobe bronchus was blocked with a7Fr Arndt blocker under bronchoscopy, and partial resection of the left upper lobe was conducted. (Case2) A 75-year-old male had previously undergone right upper lobectomy for pulmonary tuberculosis and had developed right chronic empyema. Surgery was scheduled to remove a 22-mm nodule from the left lingular segment. Oral intubation was performed(inner diameter of intubation tube:8．5mm). Next, the left lingual bronchus was blocked with a7Fr Arndt blocker under bronchoscopy. Left lingular segmentectomy was carried out under thoracoscopic assistance. Intraoperative oxygenation was maintained in both cases, and the release of the block due to hypoxemia was not required in either case.
(キーワード): 肺癌 (lung cancer) / surgery / 麻酔 (anesthesia) / blocker
(徳島大学機関リポジトリ): ● Metadata: 111579
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172853638528

(徳島大学機関リポジトリ: 111579, CiNii: 1050302172853638528) Takahiro Yoshida, Hiroaki Miyata, Hiroyuki Konno, Hiraku Kumamaru, Akira Tangoku, Yoshihito Furukita, Norimichi Hirahara, Go Wakabayashi, Mitsukazu Gotoh and Masaki Mori :
Risk assessment of morbidities after right hemicolectomy based on the National Clinical Database in Japan,
Annals of Gastroenterological Surgery, Vol.2, No.3, 220-230, 2018.

(要約): Nationwide databases are expected to provide critical data to improve medical practice. The present study used such data to develop risk models for clinically important outcomes after right hemicolectomy based on preoperative risk factors. Japan's National Clinical Database (NCD) identified 38 030 cases of right hemicolectomy in the years 2011 and 2012. These were used to analyze correlations between mortality and eight selected clinical outcomes of interest by Pearson's correlation coefficient (). To construct risk models for the eight selected clinical outcomes, 80% of all the examined cases were extracted randomly as a development cohort, and preoperative risk factors for each clinical outcome were identified using a forward stepwise selection method. Morbidities predicted from the risk models were used to find areas under the receiver operator curves among the remaining 20% of the testing cohort. The following clinical outcomes were identified as highly associated with operative mortality: systemic sepsis ( = .360), renal failure ( = .341), unplanned intubation ( = .316) and central nervous system (CNS) occurrences ( = .301). Risk models containing up to 21 preoperative variables were constructed for these eight postoperative clinical outcomes. Predictive values of the eight models were as follows: surgical site infections (0.634), anastomotic leakage (0.656), systemic sepsis (0.816), pneumonia (0.846), unplanned intubation (0.838), renal failure (0.883), CNS occurrences (0.833) and transfusion >5 units (0.846). This study indicated that the NCD-generated risk models for six of the eight selected critical postoperative outcomes had high discrimination among right hemicolectomy patients. These risk models can accurately identify high-risk patients prior to surgery.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ags3.12067
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29863168; ● Search Scopus @ Elsevier (PMID): 29863168; ● Search Scopus @ Elsevier (DOI): 10.1002/ags3.12067

(DOI: 10.1002/ags3.12067, PubMed: 29863168) Takeshi Nishino, Takahiro Yoshida, Masakazu Goto, Seiya Inoue, Takuya Minato, Satoshi Fujiwara, Yota Yamamoto, Yoshihito Furukita, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida, Jun-ichi Seike, Takanori Miyoshi and Akira Tangoku :
The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial,
Esophagus, Vol.15, No.2, 75-82, 2018.

(要約): Daikenchuto (TJ-100), a traditional Japanese herbal medicine, is widely used in Japan. Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known. The purpose of this prospective randomized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients. Forty patients for whom subtotal esophageal resection for esophageal cancer was planned at our institute from March 2011 to August 2013 were enrolled and divided into two groups at the point of determination of the operation schedule after informed consent was obtained: a TJ-100 (15 g/day)-treated group (n = 20) and a control group (n = 20). The primary efficacy end-points were maintenance of the nutrition condition and the recovery of gastrointestinal function. The secondary efficacy end-points were the serum C-reactive protein (CRP) level and adrenomedullin level during the postoperative course, the incidence of postoperative complications, and the length of hospital stay after surgery. We examined 39 patients because one patient in the TJ-100 group was judged as having unresectable cancer after surgery. The mean age of the TJ-100 group patients was significantly older than that of the control group patients.The rate of body weight decrease at postoperative day 21 was significantly suppressed in the TJ-100 group (3.6% vs. the control group: 7.0%, p = 0.014), but the serum albumin level was not significantly different between the groups. The recovery of gastrointestinal function regarding flatus, defecation, and oral intake showed no significant between-group differences, but postoperative bowel symptoms tended to be rare in the TJ-100 group. There was no significant between-group difference in the length of hospital stay after surgery. The serum CRP level at postoperative day 3 was 4.9 mg/dl in the TJ-100 group and 6.9 mg/dl in the control group, showing a tendency of a suppressed serum CRP level in the TJ-100 group (p = 0.126). The rate of increase in adrenomedullin tended to be high postoperatively, but there was no significant difference between the two groups. TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss, and it might suppress the excess inflammatory reaction related to surgery.
(キーワード): Adrenomedullin / Aged / C-Reactive Protein / Defecation / Eating / Esophageal Neoplasms / Esophagectomy / Female / Gastrointestinal Tract / Humans / Length of Stay / Male / Middle Aged / Nutritional Status / Phytotherapy / Plant Extracts / Postoperative Complications / Prospective Studies / Recovery of Function / Serum Albumin / Weight Loss
(徳島大学機関リポジトリ): ● Metadata: 115097
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-017-0601-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29892933; ● CiNii @ 国立情報学研究所 (CRID): 1521699229821638272; ● Summary page in Scopus @ Elsevier: 2-s2.0-85038619573

(徳島大学機関リポジトリ: 115097, DOI: 10.1007/s10388-017-0601-9, PubMed: 29892933, CiNii: 1521699229821638272, Elsevier: Scopus) Yoshimasa Miyagawa, Yosuke Matsushita, Hiromu Suzuki, Masato Komatsu, Tetsuro Yoshimaru, Ryuichiro Kimura, Ayako Yanai, Junko Honda, Akira Tangoku, Mitsunori Sasa, Yasuo Miyoshi and Toyomasa Katagiri :
Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer.,
International Journal of Oncology, 2018.

(要約): Triple-negative breast cancer (TNBC), defined as breast cancer lacking estrogen- and progesterone‑receptor expression and human epidermal growth factor receptor 2 (HER2) amplification, is a heterogeneous disease. RNA-sequencing analysis of 15 TNBC specimens and The Cancer Genome Atlas-TNBC dataset analysis identified the frequent downregulation of leucine-rich repeat-containing 26 (LRRC26), which negatively regulates nuclear factor-κB (NF-κB) signaling, in TNBC tissues. Quantitative polymerase chain reaction and bisulfite pyrosequencing analyses revealed that LRRC26 was frequently silenced in TNBC tissues and cell lines as a result of promoter methylation. LRRC26 expression was restored by 5-aza-2'-deoxycytidine (5'-aza-dC) treatment in HCC1937 TNBC cells, which lack LRRC26 expression. Notably, small interfering RNA-mediated knockdown of LRRC26 expression significantly enhanced the anchorage-independent growth, invasion and migration of HCC70 cells, whereas ectopic overexpression of LRRC26 in BT20 cells suppressed their invasion and migration. Conversely, neither knockdown nor overexpression of LRRC26 had an effect on cell viability in the absence of tumor necrosis factor-α (TNF-α) stimulation. Meanwhile, overexpression of LRRC26 caused the reduction of TNF-α-mediated NF-κB luciferase reporter activity, whereas depleting LRRC26 expression resulted in the upregulation of TNF-α-mediated NF-κB downstream genes [interleukin-6 (IL-6), IL-8 and C-X-C motif chemokine ligand-1]. Taken together, these findings demonstrate that LRRC26 is frequently downregulated in TNBC due to DNA methylation and that it suppresses the TNF-α-independent anchorage-independent growth, invasion and migration of TNBC cells. Loss of LRRC26 function may be a critical event in the aggressiveness of TNBC cells through a TNF-α/NF-κB-independent mechanism.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2018.4301
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29512727; ● Search Scopus @ Elsevier (PMID): 29512727; ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2018.4301

(DOI: 10.3892/ijo.2018.4301, PubMed: 29512727) Mitsuhiro Tsuboi, Kazuya Kondo, Hiromitsu Takizawa, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Hisashi Ishikura, Suguru Kimura and Akira Tangoku :
A feasibility study of postoperative adjuvant chemotherapy with fluoropyrimidine S-1 in patients with stage II-IIIA non-small cell lung cancer.,
The Journal of Medical Investigation : JMI, Vol.65, 90-95, 2018.

(要約): Adjuvant chemotherapy with uracil tegafur (UFT) improved survival among patients with completely resected stage I lung adenocarcinoma. S-1, an oral dihydropyrimidine dehydrogenase (DPD)-inhibitory 5-fluorouracil, is a more potent DPD inhibitor than UFT;therefore, we hypothesized that postoperative adjuvant chemotherapy with S-1 would be effective for advanced non-small cell lung cancer (NSCLC). We conducted a feasibility study of S-1 as postoperative adjuvant chemotherapy in patients with curatively resected pathological stage bold I back 10 bold I and bold I back 10 bold I back 20 bold I A NSCLC. Adjuvant chemotherapy consisted of 9 courses (4-week administration, 2-week withdrawal) of S-1 at 80-120 mg/body per day. Twenty-four patients with completely resected NSCLC were enrolled in this study from November 2007 through December 2010. The primary endpoint was the rate of completion of the scheduled adjuvant chemotherapy. The secondary endpoints were safety, overall survival, and relapse-free survival. Five patients were censored because of disease recurrence. The planned 9 courses of S-1 were administered to completion in 8 patients. Twelve patients completed more than 70% of the planned courses. Grade 3 adverse reactions, such as elevated total bilirubin (4.2%) and pneumonitis (4.2%), were observed, but there were no Grade 4 adverse reactions. Patients who completed more than 70% of the 9 courses demonstrated better overall survival than those who completed less than 70%. Postoperative administration of S-1 may be possible with few severe adverse events as adjuvant chemotherapy for patients with curatively resected pathological stage bold I back 10 bold I -bold I back 10 bold I back 20 bold I A NSCLC. J. Med. Invest. 65:90-95, February, 2018.
(キーワード): Aged / Carcinoma, Non-Small-Cell Lung / Chemotherapy, Adjuvant / Drug Combinations / Feasibility Studies / Female / Humans / Lung Neoplasms / Male / Middle Aged / Neoplasm Staging / Oxonic Acid / Tegafur
(徳島大学機関リポジトリ): ● Metadata: 111417
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.90
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593202; ● Summary page in Scopus @ Elsevier: 2-s2.0-85044443235

(徳島大学機関リポジトリ: 111417, DOI: 10.2152/jmi.65.90, PubMed: 29593202, Elsevier: Scopus) 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
亜急性甲状腺炎との鑑別が困難であった橋本病急性増悪の1例,
日本内分泌・甲状腺外科学会雑誌, Vol.35, No.3, 204-207, 2018年.

(要約): 橋本病急性増悪は，橋本病に急性炎症症状を伴う稀な疾患である．今回，亜急性甲状腺炎と鑑別が困難であった橋本病急性増悪の1例を経験したので報告する．症例は14歳，女性．2年前に学校検診で橋本病と診断された．1年10カ月前に甲状腺腫大増悪，頸部右側の圧痛を認めた．血液検査所見では，甲状腺機能正常であり，抗Tg抗体277IU/mL，抗TPO抗体246IU/mLと高値であった．白血球，CRPは正常値であり，赤沈の軽度亢進を認めた．亜急性甲状腺炎もしくは橋本病急性増悪が疑われ，NSAIDsが投与された．しかし，頸部疼痛が改善せずprednisolone(PSL)投与が開始された．治療中，疼痛部位は移動した．また，血液検査所見で自己抗体値が低下したため，亜急性甲状腺炎の可能性も否定できなかった．PSL投与後，症状は軽減したが，PSL漸減で疼痛が再燃し，PSL中止が困難であった．再燃を繰り返すことから橋本病急性増悪と診断した．PSLの離脱困難なため手術の方針となり，甲状腺全摘を行った．
(キーワード): 橋本病急性増悪 / 亜急性甲状腺炎 / 破壊性甲状腺炎
(出版サイトへのリンク): ● Publication site (DOI): 10.11226/jaesjsts.35.3_204
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238045665920; ● Search Scopus @ Elsevier (DOI): 10.11226/jaesjsts.35.3_204

(DOI: 10.11226/jaesjsts.35.3_204, CiNii: 1390564238045665920) Mitsuhiro Tsuboi, Hiromitsu Takizawa, Mariko Aoyama and Akira Tangoku :
Surgical treatment of locally advanced papillary thyroid carcinoma after response to lenvatinib,
International Journal of Surgery Case Reports, Vol.41, 89-92, 2017.

(要約): Differentiated thyroid carcinomas (DTC) have good prognoses after complete resection. Nevertheless, when DTC is associated with an aerodigestive invasion, curative surgery is difficult to perform. However, there is no established neoadjuvant therapy for advanced DTC. A 73-year-old man with thyroid papillary carcinoma was referred to our hospital. A computed tomography examination revealed a tumor in the upper right lobe of the thyroid, and multiple bilateral enlarged lymph nodes in the neck, involving the surrounding structures. The enlarged lymph node at the right upper neck was suspected to have invaded the right internal jugular vein, and the left paratracheal lymph node was suspected to have invaded the cervical esophagus and trachea. The tumor was considered resectable; however, surgery would have been highly invasive. Therefore, we initiated neoadjuvant therapy with lenvatinib. After administration of lenvatinib, the tumor decreased in size by 84.3% and the cervical lymph nodes by 56.0%. The patient underwent a total thyroidectomy, modified neck dissection, a resection of the muscular layer of the esophagus, and a tracheal sleeve resection and reconstruction. The SELECT trial demonstrated that lenvatinib had high response rate with short response time, in patients with radioiodine-refractory DTC. The results suggested that lenvatinib could be effective as neoadjuvant therapy. For an advanced DTC that requires removal through invasive surgery, preoperative lenvatinib treatment might be one of the options for a less invasive surgery.
(徳島大学機関リポジトリ): ● Metadata: 115162
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ijscr.2017.10.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29055877; ● Summary page in Scopus @ Elsevier: 2-s2.0-85031818924

(徳島大学機関リポジトリ: 115162, DOI: 10.1016/j.ijscr.2017.10.010, PubMed: 29055877, Elsevier: Scopus) Yuji Fujita, Kiyoshi Masuda, Junichi Hamada, Katsutoshi Shoda, Takuya Naruto, Satoshi Hamada, Yuko Miyakami, Tomohiro Kohmoto, Miki Watanabe, Rizu Takahashi, Shoichiro Tange, Masako Saito, Yasusei Kudo, Hitoshi Fujiwara, Daisuke Ichikawa, Akira Tangoku, Eigo Otsuji and Issei Imoto :
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression.,
Oncotarget, Vol.8, No.60, 101130-101145, 2017.

(要約): KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which is involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions in different tissues and can have an impact on various pathological conditions. In the present study, we investigated the oncogenic functions of KHSRP and their underlying mechanisms in the pathogenesis of esophageal squamous cell carcinoma (ESCC). KHSRP expression levels were elevated in ESCC tumors when compared with those in non-tumorous tissues by immunohistochemistry, and cytoplasmic KHSRP overexpression was found to be an independent prognosticator for worse overall survival in a cohort of 104 patients with ESCC. KHSRP knockdown inhibited growth, migration, and invasion of ESCC cells. KHSRP knockdown also inhibited the maturation of cancer-associated miRNAs, such as miR-21, miR-130b, and miR-301, and induced the expression of their target mRNAs, such as BMP6, PDCD4, and TIMP3, resulting in the inhibition of epithelial-to-mesenchymal transition. Our findings uncover a novel oncogenic function of KHSRP in esophageal tumorigenesis and implicate its use as a marker for prognostic evaluation and as a putative therapeutic target in ESCC.
(徳島大学機関リポジトリ): ● Metadata: 110988
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.20926
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29254151; ● Search Scopus @ Elsevier (PMID): 29254151; ● Search Scopus @ Elsevier (DOI): 10.18632/oncotarget.20926

(徳島大学機関リポジトリ: 110988, DOI: 10.18632/oncotarget.20926, PubMed: 29254151) Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa and Akira Tangoku :
A case of metastatic follicular thyroid carcinoma complicated with Graves' disease after total thyroidectomy,
Endocrine Journal, Vol.64, No.12, 1143-1147, 2017.

(要約): Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative. The patient was treated with RAI therapy four times for four years and was receiving levothyroxine suppressive therapy. Although radioiodine uptake was observed in the lesions after the fourth course of RAI therapy, metastatic lesions had progressed. Four years after the second surgery, she had heart palpitations and tremors. Laboratory data revealed hyperthyroidism and positive TRAb. She was diagnosed with Graves' disease and received a fifth course of RAI therapy. 131I scintigraphy after RAI therapy showed strong radioiodine uptake in the metastatic lesions. As a result, the sizes and numbers of metastatic lesions decreased, and thyroid function improved. Metastatic lesions produced thyroid hormone and caused hyperthyroidism. RAI therapy was effective for Graves' disease and thyroid carcinoma.
(出版サイトへのリンク): ● Publication site (DOI): 10.1507/endocrj.EJ17-0220
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28883260; ● Summary page in Scopus @ Elsevier: 2-s2.0-85042672335

(DOI: 10.1507/endocrj.EJ17-0220, PubMed: 28883260, Elsevier: Scopus) 武知浩和, 松岡由江, 秋月佐代, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
多職種連携による緩和治療が有効であった乳腺悪性葉状腫瘍の1例,
四国医学雑誌, Vol.73, No.3,4, 169-172, 2017年.

(要約): The case subject was a woman in her50s who consulted her local clinic for the chief complaint of pain extending from the left buttock to the lower leg. A sacral lesion and giant mass in the right breast were observed, and thus on suspicion of breast cancer the subject was referred to our department. The results of needle biopsy led to the definite diagnosis of malignant phyllodes tumor. At the start of treatment the subject presented markedly reduced activities of daily living due to the pain, and upon the introduction of opioids, and performing palliative irradiation for the sacral metastasis, the pain was successfully alleviated relatively quickly. During this period, the primary lesion became ulcerated and progression of anemia was also observed, and therefore upon applying metronidazole ointment and commencing irradiation for the right breast, therapeutic effects such as tumor regression and control of anemia progression were observed. After the initial consultation the subject expressed severe anxiety, and thus intervention was requested from a nurse specialist in cancer care, who sat with the patient when her condition was explained, and listened closely to her anxiety. Thereafter, 2 courses of epirubicin and cyclophosphamide therapy as systemic chemotherapy were administered, however the disease progressed. The subject desired to receive care at a local medical institution, and thus it was decided with the help of a social worker that she be transferred to a hospice in the short-term.
(キーワード): Malignant phyllodes tumor / Palliative care / Nurse specialist in cancer care / Social worker / Hospice
(徳島大学機関リポジトリ): ● Metadata: 111048
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697877149312

(徳島大学機関リポジトリ: 111048, CiNii: 1050020697877149312) Naoya Kawakita, Kazuya Kondo, Hiroaki Toba, Akiko Yoneda, Hiromitsu Takizawa and Akira Tangoku :
A case of atypical type A thymoma with vascular invasion and lung metastasis,
General Thoracic and Cardiovascular Surgery, Vol.66, No.4, 239-242, 2017.

(要約): We present a case of type A thymoma with invasion of the left brachiocephalic vein and lung metastases. An 84-year-old man underwent extended thymectomy combined with left brachiocephalic vein reconstruction and resection of a lung metastasis. Histological examination showed vascular invasion by the tumor. The lung metastasis had high mitotic activity and slight nuclear enlargement, the so-called "atypical" features, but the main part of the primary tumor did not. However, the intravascular portion of the tumor had "atypical" histological features like the lung metastasis. It seems that "atypical" histological features are related to clinically malignant behavior.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-017-0794-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28647799; ● Summary page in Scopus @ Elsevier: 2-s2.0-85021236001

(DOI: 10.1007/s11748-017-0794-9, PubMed: 28647799, Elsevier: Scopus) Koichiro Kajiura, Hiromitsu Takizawa, Yuki Morimoto, Kiyoshi Masuda, Mitsuhiro Tsuboi, Reina Kishibuchi, Nuliamina Wusiman, Toru Sawada, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Takuya Naruto, Issei Imoto, Akira Tangoku and Kazuya Kondo :
Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours,
Lung Cancer, Vol.111, 116-123, 2017.

(要約): Aberrant methylation of promoter CpG islands (CGIs) of tumour suppressor genes is a common epigenetic mechanism underlying cancer pathogenesis. The methylation patterns of thymic tumours have not been studied in detail since such tumours are rare. Herein, we sought to identify genes that could serve as epigenetic targets for thymic neuroendocrine tumour (NET) therapy. Genome-wide screening for aberrantly methylated CGIs was performed in three NET samples, seven thymic carcinoma (TC) samples, and eight type-B3 thymoma samples. The methylation status of thymic epithelial tumours (TETs) samples was validated by pyrosequencing in a larger cohort. The expression status was analysed by quantitative polymerase chain reaction (PCR) and immunohistochemistry. We identified a CGI on a novel gene, RASSF1A, which was strongly hypermethylated in NET, but not in thymic carcinoma or B3 thymoma. RASSF1A was identified as a candidate gene statistically and bibliographically, as it showed frequent CGI hypermethylation in NET by genome-wide screening. Pyrosequencing confirmed significant hypermethylation of a RASSF1A CGI in NET. Low-grade NET tissue was more strongly methylated than high-grade NET. Quantitative PCR and immunohistochemical staining revealed that RASSF1A mRNA and protein expression levels were negatively regulated by DNA methylation. RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs. RASSF1A may represent an epigenetic therapeutic target in thymic NET.
(キーワード): Aged / CpG Islands / DNA Methylation / Female / Gene Expression Regulation / Gene Silencing / Humans / Male / Middle Aged / Neuroendocrine Tumors / Promoter Regions, Genetic / RNA, Messenger / Thymus Neoplasms / Tumor Suppressor Proteins
(徳島大学機関リポジトリ): ● Metadata: 112475
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2017.05.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28838380; ● Summary page in Scopus @ Elsevier: 2-s2.0-85025702753

(徳島大学機関リポジトリ: 112475, DOI: 10.1016/j.lungcan.2017.05.019, PubMed: 28838380, Elsevier: Scopus) Masakazu Goto, Takahiro Yoshida, Yota Yamamoto, Yoshihito Furukita, Seiya Inoue, Satoshi Fujiwara, Naoya Kawakita, Takeshi Nishino, Takuya Minato, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Jun-ichi Seike, Yoshimi Bando and Akira Tangoku :
CXCR4 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma,
Annals of Surgical Oncology, Vol.24, No.3, 832-840, 2017.

(要約): Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The chemokine CXCL12 and its receptors CXCR4 and CXCR7 were suggested to be involved in cancer invasion and metastasis. The aim of this retrospective study was to evaluate the prognostic impact of the expressions of CXCL12, CXCR4 and CXCR7 in patients with esophageal squamous cell carcinoma (ESCC). We used immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate the expressions of CXCL12, CXCR4, and CXCR7 in ESCC patients' tumor biopsy specimens obtained during preoperative endoscopy or surgery. These results were compared with the patients' clinicopathological parameters and survival. IHC was conducted for 172 patients. High expression of CXCR4 in the cytoplasm and nuclei and that of CXCR7 were associated with poor cause-specific survival (CSS) (P= .002 and .010, respectively). The specimens from 52 of the 172 patients were examined by RT-PCR and quantitative real-time PCR. The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumors compared with normal esophageal mucosae (P < .0001). The expression level of mRNA of CXCR4 was associated with poor recurrence-free survival and CSS (P = .012 and .038, respectively). CXCR4 expression is associated with poor prognosis in patients with ESCC.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Chemokine CXCL12 / Disease-Free Survival / Esophageal Neoplasms / Esophagectomy / Female / 遺伝子発現 (gene expression) / Humans / Male / Middle Aged / RNA, Messenger / Receptors, CXCR / Receptors, CXCR4 / Retrospective Studies / Survival Rate
(徳島大学機関リポジトリ): ● Metadata: 109690
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-015-4974-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26577115; ● Summary page in Scopus @ Elsevier: 2-s2.0-84947424480

(徳島大学機関リポジトリ: 109690, DOI: 10.1245/s10434-015-4974-5, PubMed: 26577115, Elsevier: Scopus) Koichiro Kajiura, Kiyoshi Masuda, Takuya Naruto, Kohmoto Tomohiro, Watanabe Miki, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Akira Tangoku and Issei Imoto :
Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma,
Oncotarget, Vol.8, No.2, 2890-2905, 2017.

(要約): In this study, we aimed to identify novel drivers that would be epigenetically altered through aberrant methylation in early-stage lung adenocarcinoma (LADC), regardless of the presence or absence of tobacco smoking-induced epigenetic field defects. Through genome-wide screening for aberrantly methylated CpG islands (CGIs) in 12 clinically uniform, stage-I LADC cases affecting six non-smokers and six smokers, we identified candidate tumor-suppressor genes (TSGs) inactivated by hypermethylation. Through systematic expression analyses of those candidates in panels of additional tumor samples and cell lines treated or not treated with 5-aza-deoxycitidine followed by validation analyses of cancer-specific silencing by CGI hypermethylation using a public database, we identified TRIM58 as the most prominent candidate for TSG. TRIM58 was robustly silenced by hypermethylation even in early-stage primary LADC, and the restoration of TRIM58 expression in LADC cell lines inhibited cell growth in vitro and in vivo in anchorage-dependent and -independent manners. Our findings suggest that aberrant inactivation of TRIM58 consequent to CGI hypermethylation might stimulate the early carcinogenesis of LADC regardless of smoking status; furthermore, TRIM58 methylation might be a possible early diagnostic and epigenetic therapeutic target in LADC.
(キーワード): Adaptor Proteins, Signal Transducing / Adenocarcinoma / Aged / Aged, 80 and over / Animals / 細胞周期 (cell cycle) / Cell Line, Tumor / Cell Proliferation / CpG Islands / DNA Methylation / Disease Models, Animal / Epigenesis, Genetic / Epigenomics / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Gene Silencing / Genes, Tumor Suppressor / Humans / Lung Neoplasms / Male / Membrane Proteins / Mice / Middle Aged / Neoplasm Staging / Promoter Regions, Genetic / Sequence Analysis, DNA / Ubiquitin
(徳島大学機関リポジトリ): ● Metadata: 110044
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.13761
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27926516; ● Summary page in Scopus @ Elsevier: 2-s2.0-85009811790

(徳島大学機関リポジトリ: 110044, DOI: 10.18632/oncotarget.13761, PubMed: 27926516, Elsevier: Scopus) Hiromitsu Takizawa, Kazuya Kondo, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Koichiro Kajiura, Yukikiyo Kawakami, Shoji Sakiyama, Akira Tangoku, Atsushi Morishita, Yasushi Nakagawa and Toshiyuki Hirose :
Autofluorescence for the diagnosis of visceral pleural invasion in non-small-cell lung cancer,
European Journal of Cardio-Thoracic Surgery, Vol.53, No.5, 987-992, 2017.

(要約): This study was conducted to evaluate the accuracy of autofluorescence as a mode of diagnosis for visceral pleural invasion of non-small-cell lung cancer compared with white-light by means of clinical questions to several thoracic surgeons. Eight independent thoracic surgeons evaluated visceral pleural invasion in 25 cases of non-small-cell lung cancer attached to the visceral pleura on lung windows of preoperative computed tomography images. At the first study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using conventional white-light images, the surgeons diagnosed visceral pleural invasion based on information in preoperative computed tomography images, histological types and videos recorded with white-light mode using a thoracoscope. At the second study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using autofluorescence, the same surgeons diagnosed visceral pleural invasion based on information in 2 videos recorded in white-light mode and in autofluorescence mode using the thoracoscope. The overall average sensitivity, specificity and accuracy of visceral pleural invasion diagnosis by white-light versus autofluorescence mode were 64.6% vs 83.3%, 53.9% vs 73.7% and 56.5% vs 76.0%, respectively. The sensitivity, specificity and accuracy of visceral pleural invasion diagnosis was improved through the additional use of the autofluorescence mode compared with the white-light mode alone.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezx419
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29228249; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047017205

(DOI: 10.1093/ejcts/ezx419, PubMed: 29228249, Elsevier: Scopus) Takeshi Nishino, Takahiro Yoshida, Seiya Inoue, Satoshi Fujiwara, Masakazu Goto, Takuya Minato, Yoshihito Furukita, Yota Yamamoto, Yasuhiro Yuasa, Hiromichi Yamai, Hirokazu Takechi, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida, Jun-ichi Seike, Takanori Miyoshi and Akira Tangoku :
Gender differences in clinicopathological features and prognosis of squamous cell carcinoma of the esophagus,
Esophagus, Vol.14, No.2, 122-130, 2017.

(徳島大学機関リポジトリ): ● Metadata: 109991
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-016-0554-4
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84988359656

(徳島大学機関リポジトリ: 109991, DOI: 10.1007/s10388-016-0554-4, Elsevier: Scopus) 西野豪志, 吉田卓弘, 井上聖也, 青山万理子, 滝沢宏光, 丹黒章, 山村佳子, 東雅之 :
外科診療におけるチーム医療の現況と展望 4．周術期の口腔ケア-食道癌，肺癌手術における周術期口腔機能管理-,
日本外科学会雑誌, Vol.118, No.2, 155-160, 2017年.

(キーワード): 食道癌 / 肺癌 / 周術期 / 口腔機能管理 / 肺炎予防
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520290883087757568

(CiNii: 1520290883087757568) Koichiro Kajiura, Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Yukikiyo Kawakami and Akira Tangoku :
A case of subcutaneous emphysema induced by a portable thoracic drainage system after pneumonectomy,
The Journal of the Japanese Association for Chest Surgery, Vol.31, No.5, 610-615, 2017.

(要約): 症例は62歳男性．右肺扁平上皮癌にて術前放射線化学療法後に胸腔鏡補助下右肺全摘術(ND2a-2)を施行した．ポータブル型胸腔ドレナージ装置であるThopazⓇ(トパーズ)にblakeドレーンⓇをつなげて術後胸腔内ドレナージした．術後，咳嗽が多く認められ，皮下気腫が増加した．トパーズのエアリーク表示量はほぼ0 ml/分であった．気管支鏡で気管支断端瘻がないことを確認した．トパーズのドレナージトラブルと判断し，ドレーン抜去すると皮下気腫は軽快した．トパーズには胸腔内圧調節機能があり，胸腔内が過陰圧になるとバルブが開き空気を吸い込ませる機能がある．本症例では咳嗽による急激な胸腔内圧上昇時に胸腔内の空気が皮下に漏れ，その結果起こった胸腔内圧の低下を感知したトパーズ経由で胸腔内へ空気が流入するという機序を繰り返したと考えられた．
(キーワード): ポータブル型胸腔ドレナージ装置 / 肺全摘術後 / 皮下気腫
(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.31.610
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679344397440; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.610

(DOI: 10.2995/jacsurg.31.610, CiNii: 1390282679344397440) 梶浦耕一郎, 先山正二, 近藤和也, 鳥羽博明, 滝沢宏光, 丹黒章 :
胸腺腫摘出術後発症した再生不良性貧血の1例,
日本呼吸器外科学会雑誌, Vol.31, No.6, 815-822, 2017年.

(要約): 胸腺腫には自己免疫性疾患が合併しやすく，時に胸腺腫摘出後に症状が顕在化することがある．胸腺腫摘出後に再生不良性貧血を発症した症例を経験したので報告する．73歳，女性．前縦隔腫瘍にて紹介され，胸骨正中切開で胸腺胸腺腫摘出術を施行した．正岡分類I期，WHO分類はB1であった．術後半年後，肺炎を発症した．術前には正常範囲内であった血液検査で，汎血球減少を認めた．骨髄穿刺にて骨髄の細胞密度は10∼20%，脂肪髄かつ骨髄球/赤芽球の比は5以上であった．Grade 5の再生不良性貧血と診断した．シクロスポリンAを中心とした加療を行ったが，発症4ヵ月後に多臓器不全にて永眠された．胸腺腫摘出後の再生不良性貧血は非常に稀な病態であるが，易感染性となり致死的となりうる．胸腺腫摘出後の経過観察の際には再発のみならず，自己免疫疾患の合併にも注意を必要とする．
(キーワード): 胸腺胸腺腫摘出術後 / 再生不良性貧血
(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.31.815
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204366292992; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.815

(DOI: 10.2995/jacsurg.31.815, CiNii: 1390001204366292992) Takahiro Yoshida, Yoshihito Furukita, Yota Yamamoto, Takeshi Nishino, Seiya Inoue, Masami Morimoto, Kazumasa Okumura, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
A randomized, open label study of the efficacy of prophylactic 24-h low-dose landiolol for atrial fibrillation in transthoracic esophagectomy,
Esophagus, Vol.14, No.1, 97-103, 2017.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-016-0553-5
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84984781204

(DOI: 10.1007/s10388-016-0553-5, Elsevier: Scopus) Naoya Kawakita, Hiromitsu Takizawa, Koichiro Kajiura and Akira Tangoku :
Indocyanine Green Fluorescence Intraoperative Imaging for Hepatic Hydrothorax With a Small Diaphragmatic Defect,
Seminars in Thoracic and Cardiovascular Surgery, Vol.28, No.2, 606-608, 2016.

(キーワード): Aged, 80 and over / Diaphragm / Disease Progression / Fatal Outcome / Fluorescent Dyes / Humans / Hydrothorax / Indocyanine Green / Intraoperative Care / Liver Cirrhosis / Male / Optical Imaging / Pleural Effusion / Predictive Value of Tests / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 112121
(出版サイトへのリンク): ● Publication site (DOI): 10.1053/j.semtcvs.2016.08.006
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28043485; ● Search Scopus @ Elsevier (PMID): 28043485; ● Search Scopus @ Elsevier (DOI): 10.1053/j.semtcvs.2016.08.006

(徳島大学機関リポジトリ: 112121, DOI: 10.1053/j.semtcvs.2016.08.006, PubMed: 28043485) 澤田徹, 日野弘之, 松本大昌, 坂本晋一, 髙嶋美佳, 滝沢宏光, 丹黒章, 篠原勉, 大串文隆 :
有瘻性膿胸に対してEWS を用いた気管支充填術と瘻孔内フィブリン糊注入の併用が有効であった1例,
四国医学雑誌, Vol.72, No.3-4, 137-142, 2016年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697877391616

(CiNii: 1050020697877391616) 澤田徹, 日野弘之, 松本大昌, 坂本晋一, 高橋直希, 香川耕造, 髙嶋美佳, 岡野義夫, 町田久典, 畠山暢生, 滝沢宏光, 丹黒章, 篠原勉, 大串文隆 :
肺アスペルギローマ術後肺瘻に対してPushampSlide法とロープウェイ法を応用したEWS による気管支充填術が有用であった1例,
四国医学雑誌, Vol.72, No.3-4, 125-130, 2016年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807524608

(CiNii: 1050865122807524608) Naoya Kawakita, Hiromitsu Takizawa, Kazuya Kondo, Shoji Sakiyama and Akira Tangoku :
Indocyanine Green Fluorescence Navigation Thoracoscopic Metastasectomy for Pulmonary Metastasis of Hepatocellular Carcinoma,
Annals of Thoracic and Cardiovascular Surgery, Vol.22, No.6, 367-369, 2016.

(要約): Indocyanine green can selectively accumulate in primary hepatocellular carcinoma (HCC) and extrahepatic metastases. We report a patient who underwent resection of pulmonary metastasis of HCC using a thoracoscopic near-infrared imaging system and fluorescent navigation surgery. A 66-year-old man with suspicion of pulmonary metastasis of HCC was referred to our hospital. Indocyanine green was injected intravenously at a dose of 0.5 mg/kg body weight, 20 h before thoracoscopic surgery. An endoscopic indocyanine green near-infrared fluorescence imaging system showed clear blue fluorescence, indicating pulmonary metastasis of HCC in a lingular segment. We performed wide wedge resection using the fluorescence image for navigation to confirm the surgical margins. The specimen was histologically confirmed as a pulmonary metastasis of HCC. In conclusion, thoracoscopic indocyanine green near-infrared fluorescence imaging for pulmonary metastases of HCC is useful in identifying tumor locations and ensuring resection margins.
(キーワード): Aged / Carcinoma, Hepatocellular / Fluorescent Dyes / Humans / Indocyanine Green / Injections, Intravenous / Liver Neoplasms / Luminescent Measurements / Lung Neoplasms / Male / Margins of Excision / Metastasectomy / Pneumonectomy / Predictive Value of Tests / Surgery, Computer-Assisted / Thoracoscopy / Tomography, X-Ray Computed / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 114552
(出版サイトへのリンク): ● Publication site (DOI): 10.5761/atcs.cr.15-00367
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27193496; ● Summary page in Scopus @ Elsevier: 2-s2.0-85006725796

(徳島大学機関リポジトリ: 114552, DOI: 10.5761/atcs.cr.15-00367, PubMed: 27193496, Elsevier: Scopus) 西野豪志, 滝沢宏光, 吉田卓弘, 乾友浩, 髙杉遥, 松本大資, 河北直也, 井上聖也, 先山正二, 丹黒章, 東雅之, 山村佳子 :
肺癌・食道癌の周術期における口腔ケアの現状とその効果,
胸部外科, Vol.69, No.1, 30-34, 2016年.

(キーワード): 食道癌 / 肺癌 / 口腔ケア / 術後肺炎 / esophageal cancer / lung cancer / oral health care management / postoperative pneumonia
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26975640; ● CiNii @ 国立情報学研究所 (CRID): 1390283684942679808; ● Summary page in Scopus @ Elsevier: 2-s2.0-84979797876

(PubMed: 26975640, CiNii: 1390283684942679808, Elsevier: Scopus) 宇山攻, Shoji Sakiyama, Mitsuteru Yoshida, Koichiro Kenzaki, Hiroaki Toba, Yukikiyo Kawakami, Kazumasa Okumura, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 182-186, 2016.

(要約): The mortality and morbidity of chronic obstructive pulmonary disease are high. However, no radical therapy has been developed to date. The purpose of this study was to evaluate whether fetal mouse lung tissue can grow and differentiate in the emphysematous lung. Fetal lung tissue from green fluorescent protein C57BL/6 mice at 16 days' gestation was used as donor material. Twelve-month-old pallid mice were used as recipients. Donor lungs were cut into small pieces and implanted into the recipient left lung by performing thoracotomy under anesthesia. The recipient mice were sacrificed at day 7, 14, and 28 after implantation and used for histological examination. Well-developed spontaneous pulmonary emphysema was seen in 12-month-old pallid mice. Smooth and continuous connection between implanted fetal lung tissue and recipient lung was recognized. Air space expansion and donor tissue differentiation were observed over time. We could clearly distinguish the border zones between injected tissue and native tissue by the green fluorescence of grafts. Fetal mouse lung fragments survived and differentiated in the emphysematous lung of pallid mice. Implantation of fetal lung tissue in pallid mice might lead to further lung regeneration research from the perspective of respiratory and exercise function. J. Med. Invest. 63: 182-186, August, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111178
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.182
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644555; ● Summary page in Scopus @ Elsevier: 2-s2.0-84987925398

(徳島大学機関リポジトリ: 111178, DOI: 10.2152/jmi.63.182, PubMed: 27644555, Elsevier: Scopus) Miyuki Kanematsu, Masami Morimoto, Masako Takahashi, Junko Honda, Yoshimi Bando, Takuya Moriya, Yukiko Tadokoro, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida, Hiroaki Toba, Mitsuteru Yoshida, Aiichiro Kajikawa, Akira Tangoku, Issei Imoto and Mitsunori Sasa :
Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 192-198, 2016.

(要約): Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed. J. Med. Invest. 63: 192-198, August, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111180
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.192
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644557; ● Summary page in Scopus @ Elsevier: 2-s2.0-84987887510

(徳島大学機関リポジトリ: 111180, DOI: 10.2152/jmi.63.192, PubMed: 27644557, Elsevier: Scopus) 坪井光弘, 三好孝典, 青山万理子, 日野直樹, 先山正二, 近藤和也, 丹黒章 :
難治性有瘻性膿胸に気管支塞栓術を併用した有茎大網充填術が有効であった1例,
気管支学, Vol.38, No.3, 235-240, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.38.3_235
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204740787328; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.38.3_235

(DOI: 10.18907/jjsre.38.3_235, CiNii: 1390001204740787328) 鳥羽博明, 監﨑孝一郎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
急速に増大する巨大気腫性肺囊胞に対して囊胞内吸引後にEWSとフィブリン糊注入で軽快した1例,
気管支学, Vol.38, No.4, 324-327, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.38.4_324
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.38.4_324

(DOI: 10.18907/jjsre.38.4_324) 滝沢宏光, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
胸腔鏡下右上葉切除術の手術時間に影響する因子の検討,
日本呼吸器外科学会雑誌, Vol.30, No.1, 2-7, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.30.2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.30.2

(DOI: 10.2995/jacsurg.30.2) Masami Morimoto, Masako Takahashi, Junko Honda, Takahiro Yoshida, Mitsuteru Yoshida, Hiroaki Toba, Issei Imoto, Akira Tangoku and Mitsunori Sasa :
Assay of serum E2 concentration in postmenopausal breast cancer patients using a high-sensitivity RIA method is generally useful.,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 236-240, 2016.

(要約): Serum E2 levels determined for postmenopausal women by RIA and LC-MS/MS generally correlated well. High-sensitivity RIA is a potentially useful clinical assay, but it overestimated serum E2 in some women. J. Med. Invest. 63: 236-240, August, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111187
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.236
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644565; ● Search Scopus @ Elsevier (PMID): 27644565; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.63.236

(徳島大学機関リポジトリ: 111187, DOI: 10.2152/jmi.63.236, PubMed: 27644565) 松本大資, 滝沢宏光, 高嶋美佳, 川上行奎, 近藤和也, 丹黒章 :
肺葉切除22年後に胸壁転移を認めたALK融合遺伝子陽性肺癌の1例,
肺癌, Vol.56, No.7, 1046-1050, 2016年.

(要約): 背景．肺癌術後に長期間無再発生存し，遠隔臓器に病変の出現を認めた場合，再発であるか新規病変であるのかを判断するのは困難である．今回われわれは肺葉切除の22年後に出現した胸壁腫瘍に対し，anaplastic lymphoma kinase(ALK)融合遺伝子を検索することにより肺癌の胸壁転移と診断した1例を経験したため，報告する．症例．80歳男性．58歳時に肺腺癌(pT4N2M0 Stage III)に対して左肺上葉切除術を施行した．術後補助化学療法を行い，10年間再発を認めず経過観察を終了した．術後22年目に前胸部の無痛性腫瘤が出現し，生検で腺癌の所見であった．TTF-1陽性，ALK融合遺伝子陽性から肺腺癌の転移が疑われ，初回手術の病理標本もALK融合遺伝子陽性であったことから，胸壁転移と診断した．Crizotinibにて治療し腫瘍は縮小したが，薬剤性間質性肺炎を発症し中止した．プラチナ併用レジメンに変更して加療し，現在も経過観察を継続している．結論．術後遠隔期に再発転移を疑う病変が出現した場合，病理組織診断に加えALK融合遺伝子などの遺伝子変異検索を行うことで診断に至る可能性がある．
(キーワード): 肺癌 / ALK / 遠隔期再発
(出版サイトへのリンク): ● Publication site (DOI): 10.2482/haigan.56.1046
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204683808512; ● Search Scopus @ Elsevier (DOI): 10.2482/haigan.56.1046

(DOI: 10.2482/haigan.56.1046, CiNii: 1390001204683808512) Hiroaki Toba, Shoji Sakiyama, Hiromitsu Takizawa and Akira Tangoku :
Safe and successful treatment with afatinib in three postoperative non-small cell lung cancer patients with recurrences following gefitinib/erlotinib-induced hepatotoxicity.,
The Journal of Medical Investigation : JMI, Vol.63, No.1-2, 149-151, 2016.

(要約): Afatinib could be a well-tolerated EGFR-TKI that could be chosen for its relatively low hepatotoxicity, which is attributable to its having a different metabolic mechanism compared to other EGFR-TKIs. J. Med. Invest. 63: 149-151, February, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111176
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.149
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27040072; ● Summary page in Scopus @ Elsevier: 2-s2.0-84962204130

(徳島大学機関リポジトリ: 111176, DOI: 10.2152/jmi.63.149, PubMed: 27040072, Elsevier: Scopus) Yasuhiro Tamaki, Yoshifumi Ikeda, Yoshiyuki Usui, Ritsuko Okamura, Kaoru Kitamura, Kazuo Shimizu and Akira Tangoku :
Breast.,
Asian Journal of Endoscopic Surgery, Vol.8, No.4, 374-378, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12261
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26708580; ● Summary page in Scopus @ Elsevier: 2-s2.0-84988499787

(DOI: 10.1111/ases.12261, PubMed: 26708580, Elsevier: Scopus) Yasuhiro Tamaki, Yoshifumi Ikeda, Yoshiyuki Usui, Ritsuko Okamura, Kaoru Kitamura, Shimizu Kazuo and Akira Tangoku :
Thyroid and parathyroid glands.,
Asian Journal of Endoscopic Surgery, Vol.8, No.4, 379-381, 2015.

(キーワード): Thyroid / 副甲状腺 (parathyroid gland)
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/ases.12264
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26708581; ● Summary page in Scopus @ Elsevier: 2-s2.0-84988521347

(DOI: 10.1111/ases.12264, PubMed: 26708581, Elsevier: Scopus) 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
発症予測が困難であった肺癌術後間質性肺炎急性増悪の2例,
四国医学雑誌, Vol.71, No.3,4, 81-86, 2015年.

(要約): Acute exacerbation of interstitial pneumonia (IP) is one of the most severe and fatal postoperative complications in lung cancer patients underlying IP. We treated two patients suffered from acute exacerbation of IP after pulmonary resection for lung cancer. We analyzed their clinical findings. Thoracoscopic lobectomy with mediastinal lymph node dissection was performed in these cases. The patients were diagnosed with acute exacerbation 4 or 5 days after operation and treated with steroids. Both patients had not been diagnosed as IPs before surgery, however, IPs were diagnosed by retrospective analysis of pathological examination for the removal lungs. Chest CT before surgery showed an interstitial shadow in the lung field faintly in these cases. It should be considered that patients who show a faint interstitial shadow in chest CT could potentially cause an acute exacerbation of IP after lung cancer operation.
(キーワード): 肺癌 (lung cancer) / interstitial pneumonia / acute exacerbation
(徳島大学機関リポジトリ): ● Metadata: 109923
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807673216

(徳島大学機関リポジトリ: 109923, CiNii: 1050865122807673216) Hiroshi Kondo, Keiko Miyoshi, Shoji Sakiyama, Akira Tangoku and Takafumi Noma :
Differential Regulation of Gene Expression of Alveolar Epithelial Cell Markers in Human Lung Adenocarcinoma-Derived A549 Clones,
Stem Cells International, Vol.2015, 165867, 2015.

(要約): Stem cell therapy appears to be promising for restoring damaged or irreparable lung tissue. However, establishing a simple and reproducible protocol for preparing lung progenitor populations is difficult because the molecular basis for alveolar epithelial cell differentiation is not fully understood. We investigated an in vitro system to analyze the regulatory mechanisms of alveolus-specific gene expression using a human alveolar epithelial type II (ATII) cell line, A549. After cloning A549 subpopulations, each clone was classified into five groups according to cell morphology and marker gene expression. Two clones (B7 and H12) were further analyzed. Under serum-free culture conditions, surfactant protein C (SPC), an ATII marker, was upregulated in both H12 and B7. Aquaporin 5 (AQP5), an ATI marker, was upregulated in H12 and significantly induced in B7. When the RAS/MAPK pathway was inhibited, SPC and thyroid transcription factor-1 (TTF-1) expression levels were enhanced. After treatment with dexamethasone (DEX), 8-bromoadenosine 3'5'-cyclic monophosphate (8-Br-cAMP), 3-isobutyl-1-methylxanthine (IBMX), and keratinocyte growth factor (KGF), surfactant protein B and TTF-1 expression levels were enhanced. We found that A549-derived clones have plasticity in gene expression of alveolar epithelial differentiation markers and could be useful in studying ATII maintenance and differentiation.
(徳島大学機関リポジトリ): ● Metadata: 114178
(出版サイトへのリンク): ● Publication site (DOI): 10.1155/2015/165867
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26167183; ● Summary page in Scopus @ Elsevier: 2-s2.0-84934273618

(徳島大学機関リポジトリ: 114178, DOI: 10.1155/2015/165867, PubMed: 26167183, Elsevier: Scopus) 丹黒章, 田所由紀子, 武知浩和, 鳥羽博明, 中川美砂子 :
これからの遺伝子診療を考える遺伝性乳がんについて,
四国医学雑誌, Vol.71, No.5,6, 105-110, 2015年.

(キーワード): Hereditary breast cancer and/or ovarian cancer (HBOC) / familial breast cancer / BRCA 1, 2
(徳島大学機関リポジトリ): ● Metadata: 109932

(徳島大学機関リポジトリ: 109932) Misako Nakagawa, Masami Morimoto, Hirokazu Takechi, Yukiko Tadokoro and Akira Tangoku :
Preoperative diagnosis of sentinel lymph node (SLN) metastasis using 3D CT lymphography (CTLG).,
Breast Cancer, Vol.23, No.3, 519-524, 2015.

(要約): Sentinel lymph node biopsy (SLNB) became a standard procedure for patients with early breast cancer, however, an indication of SLN navigation to metastatic disease may lead to misdiagnosis for staging. Preoperative CTLG with a water-soluble iodinated contrast medium visualizes the correct primary SLNs and its afferent lymphatic channels surrounding detailed anatomy, therefore it can predict LN metastasis by visualizing the lymph vessel obstruction or stain defect of the SLN by tumor. The current study presents the value of CTLG for preoperative prediction for SLN status. A total of 228 patients with Tis-T2 breast cancer who did not receive primary chemotherapy were studied. SLN metastasis was diagnosed according to the following staining patterns of SLNs and afferent lymphatic vessels: stain defect of SLN, obstruction, stagnation, dilation, and detour of the lymphatic vessels by tumor occupation. The diagnosis was compared with the pathological results to evaluate the accuracy of prediction for SLN metastasis using CTLG. Twenty-seven of 228 patients had metastatic SLN pathologically. Twenty-five of these were diagnosed as metastatic preoperatively. The accuracy for metastatic diagnosis using CTLG was 89.0 %, sensitivity was 92.6 %, and specificity was 88.6 %. The positive predictive value was 52.1 % and negative predictive value was 98.8 %. CTLG can select the candidate with truly node negative cases in early breast cancer patients, because it predicts lymph node metastasis preoperatively from natural status of the lymphographic image. It also might omit the SLN biopsy itself.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-015-0597-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25814093; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925651439

(DOI: 10.1007/s12282-015-0597-8, PubMed: 25814093, Elsevier: Scopus) Masami Morimoto, Yoshimi Bando, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida, Junko Honda, Yukiko Tadokoro, Takuya Moriya, Mitsunori Sasa and Akira Tangoku :
Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable.,
Breast Cancer, Vol.23, No.4, 577-582, 2015.

(要約): HER2 and Ki67 were analyzed in TSC from 36 and 28 patients, respectively. The HER2 expression scores in the TSC and HS groups showed good agreement (kappa value =0.640) and significant correlation (correlation coefficient =0.860, p < 0.001). The Ki67 indexes in the TSC and HS groups also showed significant correlation (correlation coefficient =0.861, p < 0.001).
(キーワード): 乳癌 (breast cancer)
(徳島大学機関リポジトリ): ● Metadata: 114526
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-015-0605-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25808597; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925679901

(徳島大学機関リポジトリ: 114526, DOI: 10.1007/s12282-015-0605-z, PubMed: 25808597, Elsevier: Scopus) Masakazu Goda, Osamu Jinnouchi, Tsukasa Takaoka, Koji Abe, Koichi Tamura, Yutaka Nakaya, Yoshihito Furukita, Hirokazu Takechi, Akira Tangoku and Noriaki Takeda :
Efficacy of percutaneous endoscopic gastrostomy on unplanned treatment interruption and nutritional status in patients undergoing chemoradiotherapy for advanced head and neck cancer.,
The Journal of Medical Investigation : JMI, Vol.62, No.3-4, 173-176, 2015.

(要約): It is suggested that therapeutic PEG placement is useful for preventing unplanned interruption of CRT in patients with advanced head and neck cancer. After severe mucositis and inadequate oral intake have developed during CRT, PEG placement should be considered before the radiation therapy dose of 30 Gy.
(徳島大学機関リポジトリ): ● Metadata: 111274
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.62.173
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26399343; ● Summary page in Scopus @ Elsevier: 2-s2.0-84942051222

(徳島大学機関リポジトリ: 111274, DOI: 10.2152/jmi.62.173, PubMed: 26399343, Elsevier: Scopus) 滝沢宏光, 武知浩和, 坂本晋一, 住友弘幸, 坪井光弘, 中川靖士, 丹黒章 :
甲状腺未分化癌に対するsorafenibによる治療経験,
日本内分泌・甲状腺外科学会雑誌, Vol.32, No.1, 49-52, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.11226/jaesjsts.32.1_49
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001205427058176; ● Search Scopus @ Elsevier (DOI): 10.11226/jaesjsts.32.1_49

(DOI: 10.11226/jaesjsts.32.1_49, CiNii: 1390001205427058176) Mitsuteru Yoshida, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
Thoracoscopic pericardial fenestration for effective long-term management of non-tuberculous mycobacterium pericarditis,
General Thoracic and Cardiovascular Surgery, Vol.63, No.1, 49-51, 2015.

(要約): The long-term consequences of non-tuberculous mycobacterium pericarditis with pericardial effusion after fenestration have not been described. We encountered a case of non-tuberculous mycobacterium pericarditis in a 59-year-old woman with an underlying collagenosis. Repeated drainage was required because of rapid reaccumulation of the effusion. To definitively control the effusion, pericardial fenestration was performed by video-assisted thoracoscopic surgery. Chest radiography performed 6 years postoperatively showed no accumulation of pericardial or pleural fluid. The patient required careful follow-up and, to date, the pulmonary non-tuberculous mycobacterium (NTM) infection has been successfully suppressed by continuous antibiotic therapy. Pericardial fenestration with antibiotic therapy was an appropriate treatment for recurrent effusion in this case of NTM pericarditis.
(キーワード): Drainage / Female / Humans / Middle Aged / Mycobacterium Infections, Nontuberculous / Pericardial Effusion / Pericardiectomy / Pericarditis / Thoracic Surgery, Video-Assisted
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-013-0273-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23800889; ● Summary page in Scopus @ Elsevier: 2-s2.0-84879230822

(DOI: 10.1007/s11748-013-0273-x, PubMed: 23800889, Elsevier: Scopus) Takahiro Yoshida, Akira Tangoku, Yoshihito Furukita, Takeshi Nishino and Hirokazu Takechi :
Long-term survival for advanced esophageal cancer patients with an esophago-bronchial fistula can be achieved by timely multimodality therapy,
Esophagus, Vol.12, No.3, 277-285, 2015.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-014-0435-7
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-84943362007

(DOI: 10.1007/s10388-014-0435-7, Elsevier: Scopus) 梶浦耕一郎, 滝沢宏光, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
人工呼吸器管理中の慢性有瘻性膿胸に対してEWSを用いた気管支充填術を施行した1例,
気管支学, Vol.37, No.4, 409-413, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.37.4_409
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731563264; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.37.4_409

(DOI: 10.18907/jjsre.37.4_409, CiNii: 1390282679731563264) 坪井光弘, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
胸腔鏡下気管支動脈結紮を施行した気管支動脈蔓状血管腫の1例,
日本臨床外科学会雑誌, Vol.76, No.10, 2417-2421, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.76.2417
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679827683712; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.76.2417

(DOI: 10.3919/jjsa.76.2417, CiNii: 1390282679827683712) Hisashi Matsuoka, Kazuya Kondo, Hiromitsu Takizawa, Haruhiko Fujino, Etsuko Sakamoto, Junji Uchida, Koh Uyama, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.,
International Journal of Oncology, Vol.46, No.2, 569-577, 2014.

(要約): S-1 is a newly developed dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine that exhibits high clinical efficacy against non-small cell lung cancers. To identify genes that may be associated with chemosensitivity to the antitumor drug S-1, we used a low density array representing 93 genes to analyze expression profiles in 4 orthotopically implanted lung cancers derived from human lung cancer cell lines (Lu99, Lu130, LC6 and A549). The tumor growth inhibition (TGI) rates of S-1 in orthotopically implanted tumors of the Lu99, Lu130, LC6 and A549 cell lines were 34.6, 37.5, 32.1 and 3.6%, respectively. The expression of the PRSS3, ABCC4, TXN, SHMT1 and CMPK genes was significantly promoted in the orthotopically implanted SCID mouse model of the 4 lung cancer cell lines by the administration of S-1, while the expression of the LMO7 and FOLH1 genes was significantly suppressed. The expression of the ABCC1, 2 and TST genes was negatively correlated with TGI. The expression of the TK1 and ERCC2 genes was positively correlated with TGI. The results of the present study suggest that the expression of the ABCC1, 2, TST, TK1 and ERCC2 genes is related to resistance to the antitumor drug S-1.
(キーワード): Animals / Antineoplastic Agents / Cell Line, Tumor / Drug Combinations / Gene Expression Regulation, Neoplastic / Humans / Lung Neoplasms / Mice / Microarray Analysis / Neoplasm Proteins / Oxonic Acid / Tegafur / Xenograft Model Antitumor Assays
(徳島大学機関リポジトリ): ● Metadata: 106443
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2014.2754
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25405593; ● Summary page in Scopus @ Elsevier: 2-s2.0-84918509235

(徳島大学機関リポジトリ: 106443, DOI: 10.3892/ijo.2014.2754, PubMed: 25405593, Elsevier: Scopus) Khalil Abdellah Hamed Ali, Hiroaki Toba, Shoji Sakiyama, Ryo Yamamoto, Hiromitsu Takizawa, Koichiro Kenzaki, Kazuya Kondo and Akira Tangoku :
Holter ECG monitoring of sympathovagal fluctuation during bronchoscopy.,
The Clinical Respiratory Journal, 2014.

(要約): Heart rate increased significantly after pre-medication compared with that before pre-medication and increased further during bronchoscopy. The coefficient of variation (CVRR ) values after pre-medication and during bronchoscopy were significantly higher than those before pre-medication (P = 0.031 and P = 0.041, respectively). The low frequency (LF) power decreased during bronchoscopy. LF powers obtained after bronchoscopy were significantly lower than those obtained before bronchoscopy (P < 0.041). The high-frequency (HF) power was found to be decreased during bronchoscopy. In particular, HF powers obtained after bronchoscopy were significantly lower than those obtained before bronchoscopy (P < 0.019). Although the LF/HF ratios increased after pre-medication, they decreased temporarily during the bronchoscope insertion.
(キーワード): ECG / bronchoscopy
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/crj.12204
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25195956; ● Search Scopus @ Elsevier (PMID): 25195956; ● Search Scopus @ Elsevier (DOI): 10.1111/crj.12204

(DOI: 10.1111/crj.12204, PubMed: 25195956) 坪井光弘, 先山正二, 住友弘幸, 坂本晋一, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺葉切除における電動式自動縫合器の使用経験,
四国医学雑誌, Vol.70, No.3-4, 57-60, 2014年.

(要約): Objective : It has been accepted to use staplers for open and video-assisted thoracic surgery, however there was a risk in stapling of the pulmonary vasculatures. A newly developed stapler, powered ECHELON FLEX (Ethicon) is an electrically-powered stapler. It may reduce tip movement during cutting and stapling, which results in reduction of the risk of trauma to surrounding tissue. The aim of this study was to evaluate powered ECHELON FLEX for pulmonary lobectomy. Methods : We reviewed 16 patients who underwent pulmonary lobectomy with powered ECHELON FLEX in our institution from December, 2013 to April, 2014. Results : There were 25 stapling for the pulmonary artery, 17 stapling for the pulmonary vein, 16 stapling for the bronchus, and 33 stapling for the pulmonary parenchyma. Though two case of oozing from the stamps of a pulmonary artery and pulmonary parenchyma, there were no serious complications related to use of the staplers. Conclusions : The powered ECHELON FLEX can be used for pulmonary lobectomy safely.
(キーワード): pulmonary lobectomy / powered stapler
(徳島大学機関リポジトリ): ● Metadata: 109754
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050302172854349952

(徳島大学機関リポジトリ: 109754, CiNii: 1050302172854349952) 滝沢宏光, 先山正二, 梶浦耕一郎, 森下敦司, 西野豪志, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肺癌ロボット手術の私費料金設定,
四国医学雑誌, Vol.70, No.3,4, 51-56, 2014年.

(要約): In Japan, the only robot surgery covered by health insurance is prostatectomy. Robot surgery for pulmonary cancer has not been approved as advanced health care, and hospitals are required to set out-of-pocket fees for surgery on their own. We calculated the fee not covered by insurance to be 1.28million yen, taking into account expenses for : (1) the use of medical equipment, (2) maintenance, (3) labor costs, and (4) medical materials and drugs. Since the fees for surgery plus hospitalization are actually incurred by patients, whether or not the hospitalization fee should be included in out-of-pocket medical fees is decided by each health care institution. In any case, it is necessary to provide patients with a summary of medical fees prior to surgery. Hospitals are required to collect data on pulmonary robot surgical cases while operating the system with medical fees incurred by individual patients.
(キーワード): 肺癌 (lung cancer) / robotic surgery / surgical fee
(徳島大学機関リポジトリ): ● Metadata: 109753
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050583647831061632

(徳島大学機関リポジトリ: 109753, CiNii: 1050583647831061632) Mohamed Mokhtar, Yukiko Tadokoro, Misako Nakagawa, Masami Morimoto, Hirokazu Takechi, Kazuya Kondo and Akira Tangoku :
Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA.,
Breast Cancer, 2014.

(要約): SLN were identified by preoperative CTLG and intraoperative SLNB with fluorescence navigation in all patients, the identification rate was 100 %. SLN metastases were detected as positive by OSNA in 9 patients (18 %), 4 were (++), 4 were (+) and 1 was (+I). SLN metastases were detected as positive by histopathology in 10 patients (20 %). The concordance rate between OSNA and permanent sections was 90 %. The negative predictive value of CTLG was 80 %.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-014-0551-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25069434; ● Search Scopus @ Elsevier (PMID): 25069434; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-014-0551-1

(DOI: 10.1007/s12282-014-0551-1, PubMed: 25069434) 滝沢宏光, 先山正二, 丹黒章, 梶浦耕一郎, 鳥羽博明 :
肺癌におけるsentinel node navigation surgery,
外科, Vol.76, No.4, 371-376, 2014年.

(キーワード): 肺癌 / センチネルリンパ節 / ナビゲーション手術
(出版サイトへのリンク): ● Publication site (DOI): 10.15106/j00393.2014127367
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001288081481984; ● Search Scopus @ Elsevier (DOI): 10.15106/j00393.2014127367

(DOI: 10.15106/j00393.2014127367, CiNii: 1390001288081481984) 滝沢宏光, 丹黒章, 先山正二, 梶浦耕一郎, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 近藤和也 :
特集:Sentinel node navigation surgery Ⅱ．各論 3．肺癌におけるsentinel node navigation surgery,
臨床整形外科, Vol.76, No.4, 371-376, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.15106/J00393.2014127367
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.15106/J00393.2014127367

(DOI: 10.15106/J00393.2014127367) Mohamed Mokhtar, Kazuya Kondo, Hiromitsu Takizawa, Tamaki Otani, Hideki Otsuka, Hitoshi Kubo, Koichiro Kajiura, Yasushi Nakagawa, Yukikiyo Kawakami, Mitsuteru Yoshida, Haruhiko Fujino, Shoji Sakiyama and Akira Tangoku :
Non-invasive monitoring of anticancer effects of cisplatin on lung cancer in an orthotopic SCID mouse model using [¹⁸F] FDG PET-CT.,
Oncology Reports, Vol.31, No.5, 2007-2014, 2014.

(要約): Positron emission tomography-computed tomography (PET-CT) with [18F] fluorodeoxyglucose (FDG) has recently been applied for evaluating tumor response to anticancer therapy. The aim of the present study was to evaluate the utility of FDG PET-CT in monitoring non-invasively and repeatedly the inhibitory effect of cisplatin (CDDP) on an orthotopic lung cancer model. Validation of in vivo FDG uptake in human lung cancer Ma44-3 cell line in an orthotopic SCID mouse model was carried out. Next, we assessed the use of FDG PET-CT to monitor the response of orthotopic lung cancer to the anticancer effect of CDDP. SCID mice were divided into the CDDP group (7 mg/kg single dose intraperitoneally) and the control group. Tumor volume and maximal standardized uptake value (SUV max) were calculated for all mice. All mice were sacrificed for histopathologic analysis. Validation of FDG PET-CT showed that tumor volume and SUV max were significantly correlated with postmortem tumor length measured in specimens (P=0.023) and (P=0.012), respectively, and there was a significant correlation between SUV max and tumor volume (P=0.048). Response monitoring showed that significant growth inhibition by CDDP in the form of SUV max of the CDDP group was significantly lower than that of the control group on day 8 (P=0.02) and on day 13 (P=0.003). Tumor volume of the CDDP group was significantly lower than that of the control group on day 13 (P=0.03). The present study supports using FDG PET-CT in monitoring tumor progression and therapeutic response of lung cancer in an orthotopic model non‑invasively and repeatedly.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2014.3056
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24604559; ● Summary page in Scopus @ Elsevier: 2-s2.0-84898640682

(DOI: 10.3892/or.2014.3056, PubMed: 24604559, Elsevier: Scopus) 森本忠興, 笠原善郎, 角田博子, 丹黒章 :
乳癌検診の過剰診断について―避けるための対応策―,
日本乳癌検診学会誌, Vol.23, No.3, 337-346, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.3804/jjabcs.23.337
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679441763584; ● Search Scopus @ Elsevier (DOI): 10.3804/jjabcs.23.337

(DOI: 10.3804/jjabcs.23.337, CiNii: 1390282679441763584) 森本忠興, 笠原善郎, 角田博子, 丹黒章 :
乳がん検診の過剰診断を避けるために,
日本がん検診・診断学会誌, Vol.22, No.2, 155-165, 2014年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1524232505822765184

(CiNii: 1524232505822765184) Mohamed Mokhtar, Kazuya Kondo, Toshiaki Namura, Abdellah H.K. Ali, Yui Fujita, Chikako Takai, Hiromitsu Takizawa, Yasushi Nakagawa, Hiroaki Toba, Koichiro Kajiura, Mitsuteru Yoshida, Yukikiyo Kawakami, Shoji Sakiyama and Akira Tangoku :
Methylation and expression profiles of MGMT gene in thymic epithelial tumors,
Lung Cancer, Vol.83, No.2, 279-287, 2014.

(要約): A key challenge in diagnosis and treatment of thymic epithelial tumors (TET) is in improving our understanding of the genetic and epigenetic changes of these relatively rare tumors. Methylation specific PCR (MSP) and immunohistochemistry were applied to 66 TET to profile the methylation status of DNA repair gene O6-methylguanine DNA methyltransferase (MGMT) and its protein expression in TET to clarify the association between MGMT status and clinicopathological features, response to chemotherapy and overall survival. MGMT methylation was significantly more frequent in thymic carcinoma than in thymoma (17/23, 74% versus 13/44, 29%; P<0.001). Loss of expression of MGMT protein was significantly more frequent in thymic carcinoma than in thymoma (20/23, 87% versus 10/44, 23%; P<0.0001). There is a significant correlation between of MGMT methylation and loss of its protein expression (P<0.0003). MGMT methylation and loss of expression were significantly more frequent in advanced thymic epithelial tumors (III/IV) than in early tumors (I/II). MGMT methylation plays a soul role in development of TET, especially in thymic carcinoma. Therefore, translation of our results from basic molecular research to clinical practice may have important implication for considering MGMT methylation as a marker and a target of future therapies in TET.
(キーワード): Adult / Aged / 発癌 (carcinogenesis) / Carcinoma / DNA Methylation / DNA Modification Methylases / DNA Repair Enzymes / Epigenesis, Genetic / Humans / Male / Middle Aged / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Promoter Regions, Genetic / Thymoma / Thymus Neoplasms / Tumor Suppressor Proteins
(徳島大学機関リポジトリ): ● Metadata: 106223
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2013.12.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24388682; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892877225

(徳島大学機関リポジトリ: 106223, DOI: 10.1016/j.lungcan.2013.12.004, PubMed: 24388682, Elsevier: Scopus) Hiromitsu Takizawa, Shoji Sakiyama, Mitsuhiro Tsuboi and Akira Tangoku :
Demonstration of the skip metastasis pathway for N2 non-small cell lung cancer.,
Journal of Thoracic and Cardiovascular Surgery, Vol.147, No.4, e50-2, 2014.

(キーワード): Aged / Carcinoma, Non-Small-Cell Lung / Female / Humans / Lung Neoplasms / Lymphatic Metastasis / Neoplasm Staging
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2013.12.058
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24518224; ● Summary page in Scopus @ Elsevier: 2-s2.0-84896506910

(DOI: 10.1016/j.jtcvs.2013.12.058, PubMed: 24518224, Elsevier: Scopus) 後藤正和, 丹黒章, 滝沢宏光, 武知浩和, 古北由仁 :
乳び胸治療における近赤外蛍光システムを用いたリンパ官造影の有用性,
外科, Vol.76, No.1, 64-67, 2014年.

(キーワード): 乳び胸 / リンパ管造影 / indocyanine green
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282763058189568

(CiNii: 1390282763058189568) 丹黒章, 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 森下敦司 :
特集食道内視鏡外科手術-必修技術- Ⅱ．悪性疾患の手術 2．縦隔鏡補助下経裂孔的食道切除術,
手術, Vol.68, No.6, 827-834, 2014年. 丹黒章, 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 森下敦司 :
専門医必修!消化器癌定型手術の標準手技アトラス食道癌7．経裂孔的食道切除術,
「手術」2014年3月臨時増刊号, Vol.68, No.4, 407-414, 2014年. Hirokazu Takechi, Kazuaki Mawatari, Nagakatsu Harada, Yutaka Nakaya, Megumi Asakura, Mutsumi Aihara, Hiromitsu Takizawa, Masakazu Goto, Takeshi Nishino, Takuya Minato, Yoshihito Furukita, Yota Yamamoto, Yasuhiro Yuasa, Hiromichi Yamai, Takahiro Yoshida, Jun-ichi Seike and Akira Tangoku :
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.,
The Journal of Medical Investigation : JMI, Vol.61, No.1-2, 59-64, 2014.

(要約): Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20 mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO(®)) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
(キーワード): glutamine / gastrointestinal toxity / anticancer drug / diamine oxidase / IgA
(徳島大学機関リポジトリ): ● Metadata: 109521
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.61.59
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705750; ● CiNii @ 国立情報学研究所 (CRID): 1390001204244693120; ● Summary page in Scopus @ Elsevier: 2-s2.0-84897937797

(徳島大学機関リポジトリ: 109521, DOI: 10.2152/jmi.61.59, PubMed: 24705750, CiNii: 1390001204244693120, Elsevier: Scopus) 今井芳枝, 中川美砂子, 雄西智惠美, 板東孝枝, 近藤和也, 森恵子, 丹黒章 :
リンパ浮腫未発症の乳がん術後患者におけるリンパ浮腫予防行動の実態,
JNI : The Journal of Nursing Investigation, Vol.12, No.1, 12-23, 2013年.

(要約): 本研究では，リンパ浮腫未発症の乳がん術後患者におけるリンパ浮腫予防行動の実態調査を行った．対象者は乳房部分切除および腋窩リンパ節郭清を行った乳がん術後患者で，現在外来通院中のリンパ浮腫未発症患者40名に構成的質問紙調査と，その内の21名に面接調査を実施した．結果，リンパ浮腫に関する知識の「リンパ浮腫の病因」，「リンパ浮腫の治療」，「リンパ浮腫の改善方法」，「生活上の注意」，「リンパ浮腫をみた経験」の知識に関して知っているかどうかにより「リンパ浮腫予防法実施状況」で有意差が認められ，継続できるか否かに差があることが示された．また，「リンパ浮腫予防法の数」との間でも有意差が認められ，知識に関して知っているかどうかにより予防法の数に差があることが示された．リンパ浮腫に対する認識および予防行動に対する認識において，それぞれ4つのカテゴリーが抽出された．以上の結果より，未発症患者であるからこそ，自身の体に関心を向け継続していく力をいかにつけていくことが重要となる．そのためにも，患者が体験する日常生活の中から予防法を考案していくことや，実感を伴いながら，知識を意味づけられる予防行動に関する指導を考案していくことが継続の支援に必要である．
(キーワード): 乳がん患者術後患者 / リンパ浮腫未発症 / 予防行動 / Postoperative breast cancer patients / having not developed lymphedema / prevention behavior
(徳島大学機関リポジトリ): ● Metadata: 113192
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697876388096

(徳島大学機関リポジトリ: 113192, CiNii: 1050020697876388096) Khasag Narmisheekh, Shoji Sakiyama, Hiroaki Toba, Mitsuteru Yoshida, Yasushi Nakagawa, Hiromitsu Takizawa, Yukikiyo Kawakami, Koichiro Kenzaki, Ali Hamed Khalil Abdellah, Kazuya Kondo and Akira Tangoku :
Monitoring of exhaled carbon monoxide and carbon dioxide during lung cancer operation,
European Journal of Cardio-Thoracic Surgery, Vol.45, No.3, 531-536, 2013.

(要約): Carbon monoxide (CO) is expelled mainly via the lungs, so that exhaled carbon monoxide (Ex-CO) concentration reflects endogenous production. Recent reports have shown that Ex-CO levels are increased in critically ill patients and after anaesthesia and surgery. However, there has been no investigation of the changes in Ex-CO level during a lung operation. We continuously monitored Ex-CO and exhaled carbon dioxide (Ex-CO2) concentrations during surgery for lung cancer. Eighteen lung cancer patients who underwent elective lung cancer lobectomy were enrolled in this study. All patients were endotracheally intubated and ventilated under general anaesthesia. Ex-CO and Ex-CO2 concentrations were separately monitored and recorded continuously using two sets of Carbolyzer® breath analysers (Taiyo Inc., Osaka, Japan). Ex-CO concentration increased rapidly in response to changes in body position from supine to decubitus and was significantly decreased when patients were once again lying back (supine 2). Upon restarting bilateral ventilation, Ex-CO concentration in the operated lung was significantly higher than that in the breathing lung. In the lateral decubitus position, Ex-CO2 concentration showed the same pattern of increase as seen for Ex-CO. In the operated lung, the Ex-CO2 concentrations changed significantly at clamping, declamping and supine 2. In the re-ventilated, operated lung, the Ex-CO2 concentration was significantly lower than in the breathing lung. In the breathing lung, the Ex-CO2 concentration did not exhibit any significant changes over the course of the operation. When breathing was restarted, the Ex-CO level of the target lung was significantly higher than that of the breathing lung. The Ex-CO concentration was also affected by the surgical body position and this change was marked and transient.
(キーワード): Aged / 二酸化炭素 (carbon dioxide) / Carbon Monoxide / Exhalation / Female / Humans / Lung Neoplasms / Male / Middle Aged / Monitoring, Physiologic / Respiration, Artificial
(徳島大学機関リポジトリ): ● Metadata: 105937
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt395
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23913245; ● Summary page in Scopus @ Elsevier: 2-s2.0-84894341845

(徳島大学機関リポジトリ: 105937, DOI: 10.1093/ejcts/ezt395, PubMed: 23913245, Elsevier: Scopus) Hiroaki Toba, Kazuya Kondo, Yohei Sadohara, Hideki Otsuka, Masami Morimoto, Koichiro Kajiura, Yasushi Nakagawa, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama, Yoshimi Bando and Akira Tangoku :
18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.,
European Journal of Cardio-Thoracic Surgery, Vol.44, No.2, e105-e112, 2013.

(要約): OBJECTIVES: The objective of this study was to evaluate the usefulness of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and the relationships among the expressions of hypoxia-inducible factor-1 (HIF-1), glucose transporter-1 (Glut-1) and vascular endothelial growth factor (VEGF), histological type, other clinical factors and FDG uptake in thymic epithelial tumours. METHODS: Thirty-three patients who underwent FDG-PET/CT before treatment were reviewed. All types of tumours were reclassified into three subgroups: low-risk thymomas (types A, AB and B1), high-risk thymomas (types B2 and B3) and thymic carcinomas. Tumour contour, pattern of FDG uptake, tumour size and maximum standardized uptake value (SUVmax) were obtained. Expressions of HIF-1, Glut-1 and VEGF were analysed immunohistochemically, and these expressions were evaluated using grading scales. RESULTS: FDG uptake was visually recognized in all (100%) tumours. A homogeneous pattern of FDG uptake was increasingly observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas (P = 0.016). SUVmax for thymic carcinomas was significantly higher than that for thymomas (P = 0.008). With the optimal cut-off value of SUVmax of 5.6, the sensitivity, specificity and accuracy for diagnosing thymic carcinoma were 0.75, 0.80 and 0.79, respectively. Regarding the mean scoring of HIF-1, Glut-1 and VEGF, increasing trends were observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas. Tumour size revealed a significant correlation with SUVmax (r = 0.60, P < 0.001), and the expression of HIF-1 showed a moderate association, but the expression of Glut-1 showed no correlation with SUVmax. Regarding correlations between the expression of the three markers, there were moderate associations between HIF-1 and Glut-1, and HIF-1 and VEGF, and a significant correlation between Glut-1 and VEGF (r = 0.60, P < 0.001). In type B1 thymoma, HIF-1 and Glut-1 were partly expressed in non-neoplastic immature lymphocytes. CONCLUSIONS: FDG-PET/CT should be performed in patients with tumours in the anterior mediastinum because the pattern of FDG uptake and SUVmax are useful in the differential diagnosis of thymic epithelial tumours. Furthermore, the expressions of HIF-1, Glut-1 and VEGF might be associated with malignancy of thymic epithelial tumours. In contrast, FDG uptake might be dependent on tumour size rather than Glut-1 overexpression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt263
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23674658; ● Search Scopus @ Elsevier (PMID): 23674658; ● Search Scopus @ Elsevier (DOI): 10.1093/ejcts/ezt263

(DOI: 10.1093/ejcts/ezt263, PubMed: 23674658) Takeshi Nishino, Yota Yamamoto, Mayumi Ikeda, Masami Morimoto, Yoshihito Furukita, Masakazu Goto, Yoshihito Furukita, Hirokazu Takechi, Junichi Seike, Akira Tangoku and Haruo Fujiwara :
[Pathological Complete Response in a Case of Advanced Esophageal Cancer Invading Aorta Treated by Preoperative Chemotherapy with Docetaxel and Cisplatin plus 5-FU].,
Japanese Journal of Cancer and Chemotherapy, Vol.40, No.5, 643-646, 2013.

(要約): The patient was a 64-year-old man, diagnosed as cStage IVa esophageal cancer invading the aorta with lymph node metastasis. He received combination chemotherapy with docetaxel/cisplatin/5-FU(DFP therapy). After one course, CT and endoscopic examination showed remarkable reduction of the primary lesion and lymph node metastasis. We performed subtotal esophagectomy and gastric tube reconstruction by the retroposterior mediastinum route. The pathological specimen evidenced fibrosis and infiltration of inflammatory cells on almost all layers, but showed no viable malignant cells in the middle thoracic esophagus. Therefore, the pathological effect was judged as Grade 3(pCR). This case suggested that DFP combination chemotherapy may prove to be a useful treatment for advanced esophageal cancer with invasion to other organs.
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23863591; ● Summary page in Scopus @ Elsevier: 2-s2.0-84977280371

(PubMed: 23863591, Elsevier: Scopus) 丹黒章, 山本洋太, 古北由仁, 武知浩和, 後藤正和, 西野豪志, 雅美森本 :
【エキスパートが教える内視鏡外科手術-ポイントとなる解剖の理解】食道の鏡視下手術食道癌に対する鏡視下手術縦隔鏡下食道切除術,
消化器外科, Vol.36, No.5, 539-546, 2013年. Hiroaki Toba, Kazuya Kondo, Takanori Miyoshi, Koichiro Kajiura, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Fluoroscopy-assisted thoracoscopic resection after computed tomography-guided bronchoscopic metallic coil marking for small peripheral pulmonary lesions.,
European Journal of Cardio-Thoracic Surgery, 2013.

(要約): OBJECTIVES: To re-evaluate the efficacy of fluoroscopy-assisted thoracoscopic resection after computed tomography (CT)-guided bronchoscopic metallic coil marking (FATS-CM), which was our original method for small peripheral pulmonary lesions. METHODS: Fifty-eight patients with 63 lesions underwent FATS-CM. A metallic coil was installed in the bronchus nearest to the lesion under CT fluoroscopic guidance with ultrathin bronchoscopy. The virtual bronchoscopic navigation (VBN) system was used in 14 cases. Afterwards, we basically performed wide wedge resection (WWR) using a C-arm-shaped roentgenographic fluoroscope during thoracoscopic surgery initially, and then the final procedure was determined by intraoperative histological diagnosis. Moreover, we prospectively treated ground-glass opacity (GGO) lesions of <20 mm diameter according to our treatment protocol from September 2004. RESULTS: We could install coils in the objective bronchi in all cases. The average time required for the marking procedure was 38.9 (15-120) min. Pneumothorax was recognized in 1 (1.7%) case as a complication, but no fatal complications occurred. We could also install coils for each lesion in 4 cases (9 lesions) with multiple lesions. In 14 cases with the VBN system, the examination time and CT number were significantly reduced (P < 0.05 and <0.001, respectively), compared with those of 40 cases without the VBN system. The average interval between the CM and the operation was 5.6 (0-30) days. We never experienced a case of migration preoperatively. Sixty-two (98.4%) lesions were definitively identified, and WWRs were performed using three trocars in 58 (92.1%) cases during thoracoscopic surgery. Lobectomy was initially performed in only 1 case owing to coil migration. Thirty-seven of 40 cases (92.5%) were in line with the treatment protocol. There were no local-regional recurrences in all cases undergoing WWR. CONCLUSIONS: We could prospectively show that our method was suitable to perform WWR with a sufficient margin for small GGO lesions of <20 mm. Moreover, we reconfirmed that the advantages of our method were safety, permitting flexibility in scheduling operations and a high ability to deal with multiple lesions. Additionally, our method became a minimally invasive and mature technique by using a new VBN system.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt220
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23598353; ● Search Scopus @ Elsevier (PMID): 23598353; ● Search Scopus @ Elsevier (DOI): 10.1093/ejcts/ezt220

(DOI: 10.1093/ejcts/ezt220, PubMed: 23598353) Seiya Inoue, Hiromitsu Takizawa, Yota Yamamoto and Akira Tangoku :
Therapeutic hypothermia for severe cerebral air embolism complicating pleural lavage for empyema.,
Interactive Cardiovascular and Thoracic Surgery, Vol.17, No.1, 199-201, 2013.

(要約): Cerebral air embolism during pleural lavage is a rare, but potentially fatal complication. We present a case of severe cerebral air embolism that developed during pleural lavage for empyema and was successfully treated by therapeutic hypothermia. A 77-year old male patient with empyema developed severe cerebral air embolism during pleural lavage via a chest tube. Cranial computed tomography and cranial magnetic resonance imaging showed many small bubbles and widespread infarction in the territory of the right middle cerebral artery. The patient received therapeutic hypothermia maintained at 33°C for 24 h and could leave the hospital without delayed sequelae.
(キーワード): Aged / Cerebral Angiography / Diffusion Magnetic Resonance Imaging / Embolism, Air / Empyema, Pleural / Humans / Hypothermia, Induced / Intracranial Embolism / Magnetic Resonance Angiography / Male / Therapeutic Irrigation / Tomography, X-Ray Computed / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivt129
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23575752; ● Summary page in Scopus @ Elsevier: 2-s2.0-84879487956

(DOI: 10.1093/icvts/ivt129, PubMed: 23575752, Elsevier: Scopus) Masami Yoshioka, Daisuke Hinode, Yota Yamamoto, Yoshihito Furukita and Akira Tangoku :
Alteration of the oral environment in patients undergoing esophagectomy during the perioperative period,
Journal of Applied Oral Science, Vol.21, No.2, 183-189, 2013.

(要約): During the perioperative period, oral ingestion is changed considerably in esophagectomy patients. The aim of this study was to investigate oral environment modifications in patients undergoing esophageal cancer treatments due to changes in dietary intake and swallowing functions. Thirty patients who underwent operation for removal of esophageal cancer in Tokushima University Hospital were enrolled in this study. It was found that 1) the flow rate of resting saliva decreased significantly at postoperative period by deprived feeding for one week, although it did not recover several days after oral ingestion began, 2) the accumulation of dental plaque and the number of mutans streptococci in saliva decreased significantly after operation, while both increased relatively quick when oral ingestion began, and 3) the swallowing function decreased significantly in the postoperative period. These results suggest that dental professionals should emphasize the importance of oral health care and provide instructions on plaque control to patients during the perioperative period of esophageal cancer treatment.
(キーワード): Aged / Aged, 80 and over / Deglutition / Dental Plaque / Eating / Esophageal Neoplasms / Esophagectomy / Female / Humans / Male / Middle Aged / Perioperative Period / Saliva / Salivation / Secretory Rate / Statistics, Nonparametric / Streptococcus mutans / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1590/1678-7757201302338
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23739864; ● Search Scopus @ Elsevier (PMID): 23739864; ● Search Scopus @ Elsevier (DOI): 10.1590/1678-7757201302338

(DOI: 10.1590/1678-7757201302338, PubMed: 23739864) 西野豪志, 山本洋太, 後藤正和, 古北由仁, 武知浩和, 丹黒章 :
術前化学放射線療法が奏効し喉頭温存手術が可能となった高度進行頸部食道類基底細胞癌の1例,
手術, Vol.67, No.4, 513-516, 2013年.

(キーワード): 頸部食道癌 / 類基底細胞癌 / 術前化学放射線療法
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521699230614945408

(CiNii: 1521699230614945408) 兼松美幸, 井上聖也, 山本洋太, 古北由仁, 藤原晴夫, 丹黒章 :
術前化学療法が奏効し喉頭温存術が可能となった広範囲食道表在癌の1例,
日本臨床外科学会雑誌, Vol.74, No.3, 672-677, 2013年.

(要約): 頸部食道癌，特に表在癌に対する治療法においては，QOLを考慮した喉頭温存と根治性の点で，切除手術かCRTかの選択に難渋する．今回われわれは広範囲食道表在癌に対して，術前化学療法が奏効し喉頭温存術が可能となった1例を経験したので報告する．症例は60歳台，男性．食道入口部から胸部下部食道にかけての広範な食道表在癌と診断された(Ce-Lt，sq，cT1b(SM2)N0M0 Stage I)．喉頭温存と口側断端確保を狙い，術前化学療法(DTX/5-FU/CDDP)を行った結果，粘膜面の生検は陰性であったが，PETで集積が残存し手術を追加した．術中迅速診断では口側断端陰性が確認でき，高位での胃管吻合および根治手術が可能となった．また摘出標本はpCRであった．長期生存が期待できる食道癌に対しては手術，化学療法，放射線療法をうまく組み合わせることでQOLを確保した治療が可能である．
(キーワード): cT1b広範囲食道癌 / 術前化学療法 / 喉頭温存術
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.74.672
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204850652416; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.74.672

(DOI: 10.3919/jjsa.74.672, CiNii: 1390001204850652416) 丹黒章, 山本洋太, 古北由仁, 後藤正和, 西野豪志, 森本雅美 :
【手術をめぐるがん看護∼意思決定支援から術後リハビリテーション看護まで∼】, --- (第I章)がん手術療法の"いま" がん手術療法の最前線 ---,
がん看護, Vol.18, No.2, 111-113, 2013年.

(キーワード): *腫瘍(外科的療法)

丹黒章, 田所由紀子, 中川美砂子, 古川尊子, 池田真由美, 森本雅美, 宮本佳美 :
【手術をめぐるがん看護∼意思決定支援から術後リハビリテーション看護まで∼】, --- (第II章)がんに対する術式決定とインフォームドコンセント乳がん患者の術式決定とインフォームドコンセント ---,
がん看護, Vol.18, No.2, 126-132, 2013年.

(キーワード): *インフォームドコンセント

池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 後藤正和, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科的治療抵抗性の乳児気管支肉芽に対してHo:YAGレーザー焼灼術を施行した1例,
気管支学, Vol.35, No.2, 222, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204754813696

(CiNii: 1390001204754813696) 古川尊子, 吉田光輝, 梶浦耕一郎, 先山正二, 滝沢宏光, 森本雅美, 武知浩和, 池田真由美, 西野豪志, 中川靖士, 川上行奎, 近藤和也, 丹黒章 :
当科における気管支鏡検査へのLung pointの経験,
気管支学, Vol.35, No.2, 227-228, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731443840

(CiNii: 1390282679731443840) 梶浦耕一郎, 川上行奎, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 中川靖士, 吉田光輝, 滝沢宏光, 田所由紀子, 先山正二, 近藤和也, 丹黒章 :
YAGレーザー使用時の気管支鏡破損の1例,
気管支学, Vol.35, No.2, 228, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731441664

(CiNii: 1390282679731441664) 田中眞紀, 徳永えり子, 岩瀬弘敬, 大野真司, 田村和夫, 丹黒章, 土井原博義, 西村令喜, 光山昌珠 :
女性乳腺医師の抱える問題アンケート調査報告,
乳癌の臨床, Vol.27, No.6, 780-781, 2013年.

(キーワード): 質問紙法

山本洋太, 丹黒章, 西野豪志, 後藤正和, 古北由仁, 武知浩和 :
【消化器外科看護まるわかりいちからわかる!術前術後ケア・解剖・疾患・治療】, --- (第2章)消化器の解剖・疾患・術前術後ケア入門食道の解剖生理，疾患，検査・治療 ---,
消化器外科Nursing, Vol.18, No.1, 138-150, 2013年.

(キーワード): 局所解剖学

古北由仁, 森本雅美, 後藤正和, 山本洋太, 武知浩和, 丹黒章 :
胃食道逆流症と左腎癌に対して腹腔鏡下同時手術を施行した1例,
手術, Vol.66, No.12, 1779-1783, 2012年.

(キーワード): *胃食道逆流(外科的療法,X線診断,合併症)
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523106605546985088

(CiNii: 1523106605546985088) 古北由仁, 森本雅美, 後藤正和, 山本洋太, 武知浩和, 丹黒章 :
腹腔鏡下手術を施行したupside down stomachを呈する食道裂孔ヘルニアの1例,
日本臨床外科学会雑誌, Vol.73, No.11, 2813-2818, 2012年.

(キーワード): *胃軸捻転(合併症,外科的療法,X線診断)
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.73.2813
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.73.2813

(DOI: 10.3919/jjsa.73.2813) Tadaoki Morimoto, Akira Tangoku, Takashi Yamakawa, Masaki Tsuruno and Shigemitsu Takashima :
Promotion of quality-controlled mammography alone as a screening modality in Japan.,
Breast Cancer, Vol.21, No.4, 435-441, 2012.

(要約): BACKGROUND: The rate of breast cancer screening in Japan has not increased, and it is thought that one of the reasons is the principle that mammography (MMG) and clinical breast examination (CBE) be carried out in combination. Nationwide, there is a shortage of physicians qualified to perform CBE, and in some regions mass-screening is performed by MMG alone out of a mobile MMG bus. In Shikoku, MMG is performed alone as a screening examination in Kochi and Ehime Prefectures. METHODS: A comparative analysis of the data generated by MMG alone in breast cancer screening in the four prefectures of Shikoku during the 2005-2009 period was performed. RESULTS: The overall attendance rates, recall, cancer detection, early-stage cancer detection, and the positive predictive value (PPV) were 16.8-24.5, 6.0-12.8, 0.26-0.37, 63.1-79.7, and 2.8-4.3 %, respectively. Almost no differences were seen between the results for MMG alone and combined MMG/CBE screening. In addition, the cancer detection rates based on the Japan Cancer Society's nationwide data were 0.25 % with combined MMG/CBE screening and 0.21 % with MMG alone, showing almost no difference. CONCLUSIONS: No differences were seen between the results (i.e., recall rate, cancer detection rate, early-stage cancer detection rate, PPV) for MMG alone and MMG/CBE screening in the four prefectures of Shikoku compared with the Japan Cancer Society's nationwide data. In order to improve the mammographic screening rate in Japan, quality-controlled mammography as a stand-alone examination should be promoted, and performed biennially for women aged 50-74 years.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-012-0410-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23515946; ● Summary page in Scopus @ Elsevier: 2-s2.0-84904719919

(DOI: 10.1007/s12282-012-0410-x, PubMed: 23515946, Elsevier: Scopus) Hideki Otsuka, Yukikiyo Kawakami, Hiromitsu Takizawa, Koichiro Kenzaki, Kazuya Kondo and Akira Tangoku :
18F-fluorodeoxyglucose positron emission tomography/computed tomography is useful in postoperative follow-up of asymptomatic non-small-cell lung cancer patients.,
Interactive Cardiovascular and Thoracic Surgery, 2012.

(要約): OBJECTIVESPostoperative follow-up and surveillance after curative resection for non-small-cell lung cancer (NSCLC) patients are generally performed. However, there is no consensus on the best programme at this time. The aim of this study was to evaluate the diagnostic capability of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in postoperative NSCLC patients without clinical and radiological evidence of recurrence, as a follow-up and surveillance programme.METHODSBetween January 2005 and April 2010, a total of 101 NSCLC patients underwent potentially curative operations and follow-up FDG-PET/CT was performed in patients without clinical and radiological evidence of recurrence at least once a year in principle. A total of 233 FDG-PET/CT studies were entered and retrospectively reviewed.RESULTSEighteen (18%) asymptomatic patients had recurrent diseases and 22 recurrent sites were confirmed. Of 22 recurrent sites, recurrence was diagnosed by histological examination in 9 (41%) sites and by imaging examination in 13 (59%) sites. FDG-PET/CT correctly diagnosed recurrence in 17 of the 18 (94%) patients and 21 of the 22 (95%) recurrent sites. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 94.4, 97.6, 89.5, 98.8 and 97.0%, respectively. On the other hand, in 3 patients, other diseases were detected and treated appropriately. Post-recurrence therapies were performed in all patients with recurrence, but 4 (22%) patients died of the original diseases. The median post-recurrence survival was 25.2 months, and the 1- and 2-year post-recurrence survival rates were 83.3 and 69.6%, respectively.CONCLUSIONSFDG-PET/CT is a useful tool that has high capability to detect recurrences in asymptomatic NSCLC patients after a potentially curative operation. However, a large-scale multi-institutional randomized control trial may be needed to ascertain the benefit of surveillance with FDG-PET/CT.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivs368
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22914804; ● Search Scopus @ Elsevier (PMID): 22914804; ● Search Scopus @ Elsevier (DOI): 10.1093/icvts/ivs368

(DOI: 10.1093/icvts/ivs368, PubMed: 22914804) Mitsuteru Yoshida, Takanori Miyoshi, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
Pemphigus with thymoma improved by thymectomy: report of a case,
Surgery Today, Vol.43, No.7, 806-808, 2012.

(要約): A 53-year-old female with pemphigus vulgaris received treatment with prednisolone for 3 years. On chest computed tomography performed at follow-up, an anterior-mediastinal tumor (4 cm × 3 cm) was detected and diagnosed as a thymoma. Although amyosthenia was absent, the patient's anti-acetylcholine-receptor antibody level was high, and she was positive for anti-desmoglein 3 antibodies. She underwent extended thymectomy in the same year, following which both the anti-acetylcholine receptor antibody and the anti-desmoglein 3 antibody levels were normalized. The patient's skin symptoms improved, and the steroid dose was gradually lowered and finally discontinued 4 years postoperatively. Extended thymectomy may be an effective therapy for treating patients with pemphigus.
(キーワード): 自己免疫 (autoimmunity) / Female / Humans / Middle Aged / Paraneoplastic Syndromes / Pemphigus / Thymectomy / Thymoma / Thymus Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00595-012-0272-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22855008; ● Search Scopus @ Elsevier (PMID): 22855008; ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0272-z

(DOI: 10.1007/s00595-012-0272-z, PubMed: 22855008) 後藤正和, 丹黒章, 山本洋太, 雅美森本, 古北由仁, 武知浩和 :
縦隔鏡下食道切除術を行った左胸郭成形術後食道表在癌の1例,
日本臨床外科学会雑誌, Vol.73, No.7, 1659-1663, 2012年.

(キーワード): 癌腫(外科的療法,診断,病理学) / 食道表在癌 / 胸郭成形術 / 縦隔鏡
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.73.1659
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679827435520; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.73.1659

(DOI: 10.3919/jjsa.73.1659, CiNii: 1390282679827435520) Akira Tangoku, Yota Yamamoto, Yoshihito Furukita, Masakazu Goto and Masami Morimoto :
The New Era of Staging as a Key for an Appropriate Treatment for Esophageal Cancer,
Annals of Thoracic and Cardiovascular Surgery, Vol.18, No.3, 190-199, 2012.

(要約): Fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) have become the gold standard for staging of esophageal cancer by detecting distant metastases, but metastatic lymph nodes are often difficult to diagnose from the size and standardized uptake value (SUV). If we compare the diagnostic performance of endoscopic ultrasonography (EUS), CT, and FDG-PET in staging of esophageal cancer, EUS is the most sensitive method to identify the detection of regional lymph node metastases, whereas CT and FDG-PET are more specific tests. Combination study with CT, EUS and PETCT cannot make a precise diagnosis after neoadjuvant therapy (NAT). A precise staging might be determined by the fine needle aspiration biopsy (FNAB) under EUS and US screening in the neck and the abdomen even after NAT. Indication of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for superficial cancer is sensitive because of difficulty in T1b cancer diagnosis. Detailed examination about vessel invasion and the possibility of residual tumor with dissected specimen will offer an appropriate additional therapy. New strategy like sentinel lymph node (SLN) navigation could supply more information about lymphatic routes and metastatic nodes. SLN navigation with ESD might become a new less invasive strategy for superficial esophageal cancer.
(キーワード): Decision Support Techniques / Diagnostic Imaging / Endoscopic Ultrasound-Guided Fine Needle Aspiration / Endosonography / Esophageal Neoplasms / Fluorodeoxyglucose F18 / Humans / Lymphatic Metastasis / Neoplasm Invasiveness / Neoplasm Staging / Patient Selection / Positron-Emission Tomography / Predictive Value of Tests / Prognosis / Radiopharmaceuticals / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.5761/atcs.ra.12.01926
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22790989; ● CiNii @ 国立情報学研究所 (CRID): 1390001204727960320; ● Search Scopus @ Elsevier (PMID): 22790989; ● Search Scopus @ Elsevier (DOI): 10.5761/atcs.ra.12.01926

(DOI: 10.5761/atcs.ra.12.01926, PubMed: 22790989, CiNii: 1390001204727960320) 後藤正和, 先山正二, 鳥羽博明, 監﨑孝一郎, 近藤和也, 丹黒章 :
右中下葉・瘻管切除を施行した低肺機能の成人先天性食道気管支瘻の1例,
日本臨床外科学会雑誌, Vol.73, No.5, 1075-1079, 2012年.

(キーワード): 気管食道瘻 / 合併症 / 外科的療法 / 病理学
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.73.1075
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204852799872; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.73.1075

(DOI: 10.3919/jjsa.73.1075, CiNii: 1390001204852799872) 坂本晋一, 梶浦耕一郎, 滝沢宏光, 中川靖士, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 吉田光輝, 川上行奎, 田所由紀子, 先山正二, 近藤和也, 坂東良美, 岡崎弘泰, 後東久嗣, 西岡安彦, 丹黒章 :
Erlotinibでinduction therapyを行ったIIIA期非小細胞肺癌の1手術例,
四国医学雑誌, Vol.68, No.5-6, 251-256, 2012年.

(キーワード): Carcinoembryonic Antigen(血液)
(徳島大学機関リポジトリ): ● Metadata: 110365
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050020697877401472

(徳島大学機関リポジトリ: 110365, CiNii: 1050020697877401472) Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kajiura, Ali Hamed Khalil Abdellah, Shoji Sakiyama and Akira Tangoku :
Computed tomography lymphography by transbronchial injection of iopamidol to identify sentinel nodes in preoperative patients with non-small cell lung cancer : A pilot study,
Journal of Thoracic and Cardiovascular Surgery, Vol.144, No.1, 94-99, 2012.

(要約): The objective of the present study was to assess the safety and feasibility of computed tomography lymphography by transbronchial injection of a water-soluble extracellular computed tomography contrast agent. From April 2010 to May 2011, patients with clinical stage I non-small cell lung cancer who were candidates for lobectomy were enrolled in the present study. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. Computed tomography images of the chest were obtained 0.5 and 5 minutes after 2 or 3 mL of iopamidol was injected through a microcatheter. Sentinel nodes were identified when the maximum computed tomography attenuation value of the lymph nodes on the postcontrast computed tomography images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. The ultrathin bronchoscope could access the targeted bronchus, and iopamidol was delivered into the peritumoral area in all 13 patients without any complications. Sentinel nodes were identified in 12 (92.3%) of the 13 patients. The average number of sentinel nodes was 1.5 (range, 1-2). Pathologic examination revealed metastatic lymph nodes in 2 patients. Metastatic nodes were included with the sentinel nodes. Computed tomography lymphography by transbronchial injection of iopamidol was a safe and feasible method to identify the sentinel nodes in patients with clinical stage I non-small cell lung cancer.
(キーワード): Aged / Carcinoma, Non-Small-Cell Lung / Contrast Media / Female / Humans / Injections / Iopamidol / Lung Neoplasms / Lymphography / Male / Middle Aged / Neoplasm Staging / Pilot Projects / Pneumonectomy / Sentinel Lymph Node Biopsy / Thoracic Surgery, Video-Assisted / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2012.03.040
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22507846; ● Search Scopus @ Elsevier (PMID): 22507846; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2012.03.040

(DOI: 10.1016/j.jtcvs.2012.03.040, PubMed: 22507846) 鳥羽博明, 先山正二, 森本雅美, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
摘出時にラリンジアルマスクを使用した小児気管支異物の1例,
気管支学, Vol.34, No.2, 180-183, 2012年.

(要約): 背景.摘出時にラリンジアルマスクを使用した小児気管支異物の1例を経験したので報告する.症例.1歳6カ月の女児.ピーナッツを食べた際に誤嚥.その後,喘鳴が出現し,前医に入院.抗菌薬を投与されていたが,翌日施行された胸部CTにて気管支異物を疑われ,当院に搬送された.CTにて左主気管支に異物と思われる陰影を認め,気管支異物と診断し,同日全身麻酔下に異物除去を施行した.ラリンジアルマスク(サイズ2.0)を使用して気道を確保した後,外径4.0mmの軟性気管支鏡を挿入し,バルーン付きカテーテルにて摘出した.異物はピーナッツであった.結論.小児気管支異物に対して,ラリンジアルマスクの使用により,異物摘出時の有効な換気と軟性気管支鏡のスムーズな操作性を担保することができた.
(キーワード): *異物(治療,X線診断)
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679727797504

(CiNii: 1390282679727797504) 古北由仁, 森本雅美, 後藤正和, 山本洋太, 武知浩和, 丹黒章 :
Nissen噴門形成術後の再発・合併症に対する再手術の経験,
日本臨床外科学会雑誌, Vol.73, No.3, 527-531, 2012年.

(キーワード): 食道裂孔ヘルニア / 噴門形成 / 再手術
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.73.527
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204850918784; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.73.527

(DOI: 10.3919/jjsa.73.527, CiNii: 1390001204850918784) Yota Yamamoto, Yamai Hiromichi, Jun-ichi Seike, Takahiro Yoshida, Hirokazu Takechi, Yoshihito Furukita, Koichiro Kajiura, Minato Takuya, Yoshimi Bando and Akira Tangoku :
Prognosis of Esophageal Squamous Cell Carcinoma in Patients Positive for Human Epidermal Growth Factor Receptor Family Can Be Improved by Initial Chemotherapy with Docetaxel, Fluorouracil and Cisplatin,
Annals of Surgical Oncology, Vol.19, No.3, 757-765, 2012.

(要約): The human epidermal growth factor receptor (HER) family, Ki-67 and p53 are important biomarkers for several malignancies. However, few studies have examined the role of these in prognosis and therapeutic sensitivity of esophageal squamous cell carcinoma (ESCC). The efficacy of triple-drug combination therapy with docetaxel, fluorouracil and cisplatin has recently been expected for ESCC. Subjects comprised 142 patients with ESCC who underwent operation (OP group, n = 54), neoadjuvant chemotherapy with docetaxel, fluorouracil, and cisplatin (DFP therapy) followed by operation (NAC group, n = 37) or initial systemic DFP therapy (CT group, n = 51) between January 2004 and December 2010. Immunohistochemical expressions of epidermal growth factor receptor (EGFR), HER2, HER3, Ki-67, and p53 were evaluated and compared with prognosis and sensitivity to DFP therapy. Positive correlations existed between EGFR, HER2, and HER3 expressions. In the OP group, EGFR was independently associated with postoperative recurrence in multivariate analysis (P = .036). In the NAC group, EGFR correlated with pathological response to DFP therapy (P = .004). In the CT group, EGFR, HER2, and HER3 correlated with clinical response to DFP therapy and EGFR was independently associated with favorable prognosis in multivariate analysis (P = .022). EGFR represents a predictor of postoperative recurrence and sensitivity to triple-drug combination therapy including a taxane. EGFR-positive patients may show improved prognosis with taxane combination chemotherapy and molecular targeted therapy for HER family members.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Cisplatin / Disease-Free Survival / Esophageal Neoplasms / Esophagectomy / Female / Fluorouracil / Humans / 免疫組織化学 (immunohistochemistry) / Ki-67 Antigen / Male / Middle Aged / Neoadjuvant Therapy / Prognosis / Receptor, Epidermal Growth Factor / Receptor, erbB-2 / Receptor, erbB-3 / Survival Rate / Taxoids / Tumor Markers, Biological / Tumor Suppressor Protein p53
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-011-2071-y
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21947696; ● Search Scopus @ Elsevier (PMID): 21947696; ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-011-2071-y

(DOI: 10.1245/s10434-011-2071-y, PubMed: 21947696) Hiroaki Toba, Shoji Sakiyama, Koichiro Kenzaki, Yukikiyo Kawakami, Koh Uyama, Yoshimi Bando and Akira Tangoku :
Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis,
Journal of Thoracic and Cardiovascular Surgery, Vol.143, No.6, 1429-1435, 2012.

(要約): Pulmonary fibrosis is a life-threatening disease that results in progressive respiratory failure. We have suggested the possibility of fetal lung tissue as an option for further investigation into lung regeneration. The objective was to prove whether fetal lung fragments can survive and differentiate in fibrotic lung. Lewis rats were administered bleomycin and used as recipients after 3 or 4 weeks. Day 17 fetal lung tissue from green fluorescent protein Lewis rats was used as donor material. Donor lungs were removed, cut into small pieces, and implanted into the recipients' left lung. The recipients received cyclosporin to prevent immune response to green fluorescent protein and were killed after 1, 2, 4, 8, and 12 weeks and histologically evaluated. Furthermore, the expression of thyroid transcription factor-1 and Clara cell secretory protein in the implanted fetal lung tissue was immunohistologically evaluated. Fibrotic changes were recognized for a long period of time in the recipient lungs. The implanted fetal lung fragments could be clearly distinguished from recipient lungs because of the luminescence of grafts. Fetal lung fragments could survive in the recipient lungs with fibrotic changes. The air spaces of implanted fetal lungs were narrow at 1 and 2 weeks but expanded with the passage of time. The connection between the recipient lung and the implanted fetal lung was recognized, particularly in the peripheral grafts. The expression patterns of thyroid transcription factor-1 and Clara cell secretory protein in implanted lungs resembled those in the process of normal lung morphogenesis. Fetal rat lung fragments could survive and differentiate in bleomycin-induced completely fibrotic lung.
(キーワード): Animals / Animals, Genetically Modified / Bleomycin / 細胞分化 (cell differentiation) / Disease Models, Animal / Female / Graft Survival / Green Fluorescent Proteins / 免疫組織化学 (immunohistochemistry) / Lung / Lung Transplantation / Male / Nuclear Proteins / 肺線維症 (pulmonary fibrosis) / Rats / Rats, Inbred Lew / 再生 (regeneration) / Time Factors / Transcription Factors / Uteroglobin
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2012.01.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22305550; ● Search Scopus @ Elsevier (PMID): 22305550; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2012.01.002

(DOI: 10.1016/j.jtcvs.2012.01.002, PubMed: 22305550) Takuya Minato, Yota Yamamoto, Jun-ichi Seike, Takahiro Yoshida, Hiromichi Yamai, Hirokazu Takechi, Yasuhiro Yuasa, Yoshihito Furukita, Masakazu Goto, Yoshimi Bando and Akira Tangoku :
Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.,
Annals of Surgical Oncology, Vol.20, No.1, 209-217, 2012.

(要約): BACKGROUND: Aldehyde dehydrogenase 1 (ALDH1) and CD44 act as important biomarkers in several solid tumors. However, few studies have examined the relationships between ALDH1 expression and the prognosis and clinical characteristics of esophageal squamous cell carcinoma (ESCC). METHODS: This study was a retrospective case-control study and included 152 patients with ESCC. A total of 56 patients underwent surgery (OP group), 40 patients received neoadjuvant chemotherapy involving weekly docetaxel plus 5-fluorouracil and low-dose cisplatin (DFP therapy) prior to undergoing surgery (NAC group), and 56 patients received initial systemic DFP therapy (CT group). The ALDH1 and CD44 immunohistochemical expression levels of each tumor were evaluated and compared with the prognosis and clinical characteristics of the ESCC patients. RESULTS: In the OP and NAC groups, multivariate analysis found that ALDH1 was independently associated with postoperative recurrence and prognosis (OP group, P = 0.004 and 0.016, respectively; NAC group, P = 0.026 and 0.014, respectively). In addition, CD44 was found to be associated with postoperative recurrence in the OP group and prognosis in the NAC group (P = 0.024 and 0.047, respectively). Among the ALDH1-negative clinical stage II/III patients, the OP and NAC groups displayed better prognoses than the CT group (P < 0.001). However, among the ALDH1-positive clinical stage II/III patients, the OP and NAC groups displayed poorer prognoses than the CT group (P = 0.049). CONCLUSIONS: ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC.
(キーワード): Aged / Antigens, CD44 / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Case-Control Studies / Chi-Square Distribution / Cisplatin / Disease-Free Survival / Esophageal Neoplasms / Esophagectomy / Female / Fluorouracil / Humans / Isoenzymes / Kaplan-Meier Estimate / Male / Middle Aged / Multivariate Analysis / Neoadjuvant Therapy / Neoplasm Recurrence, Local / Proportional Hazards Models / Retinal Dehydrogenase / Retrospective Studies / Taxoids / Tumor Markers, Biological
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-012-2535-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22847125; ● Summary page in Scopus @ Elsevier: 2-s2.0-84871802319

(DOI: 10.1245/s10434-012-2535-8, PubMed: 22847125, Elsevier: Scopus) Yoshio Kasahara, Masaaki Kawai, Ichiro Tsuji, Eriko Tohno, Takao Yokoe, Minoru Irahara, Akira Tangoku and Noriaki Ohuchi :
Harms of screening mammography for breast cancer in Japanese women.,
Breast Cancer, 2012.

(要約): BACKGROUND: The US Preventative Services Task Force assesses the efficacy of breast cancer screening by the sum of its benefits and harms, and recommends against routine screening mammography because of its relatively great harms for women aged 40-49 years. Assessment of the efficacy of screening mammography should take into consideration not only its benefits but also its harms, but data regarding those harms are lacking for Japanese women. METHODS: In 2008 we collected screening mammography data from 144,848 participants from five Japanese prefectures by age bracket to assess the harms [false-positive results, performance of unnecessary additional imaging, fine-needle aspiration cytology (FNA), and biopsy and its procedures]. RESULTS: The rate of cancer detected in women aged 40-49 years was 0.28%. The false-positive rate (9.6%) and rates of additional imaging by mammography (5.8%) and ultrasound (7.3%) were higher in women aged 40-49 years than in the other age brackets. The rates of FNA (1.6%) and biopsy (0.7%) were also highest in women aged 40-49 years. However, they seemed to be lower than the rates reported by the Breast Cancer Surveillance Consortium (BCSC) and other studies in the US. CONCLUSIONS: The results, although preliminary, indicate the possibility that the harms of screening mammography for Japanese women are less than those for American women.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-012-0333-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22282164; ● Search Scopus @ Elsevier (PMID): 22282164; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-012-0333-6

(DOI: 10.1007/s12282-012-0333-6, PubMed: 22282164) 丹黒章, 山本洋太, 古北由仁, 武知浩和, 後藤正和, 森本雅美 :
内視鏡外科医のための微細局所解剖アトラス縦隔鏡を用いた経裂孔的食道切除術,
手術, Vol.66, No.6, 665-673, 2012年. 丹黒章, 山本洋太, 古北由仁, 後藤正和, 西野豪志, 森本雅美, 古川尊子, 池田真由美, 山崎裕行 :
食道癌の姑息的治療(ステント治療，バイパス手術),
コンセンサス癌治療, Vol.11, No.2, 103-109, 2012年. Miyuki Kanematsu, Masami Morimoto, Junko Honda, Taeko Nagao, Misako Nakagawa, Masako Takahashi, Akira Tangoku and Mitsunori Sasa :
The time since last menstrual period is important as a clinical predictor for non-steroidal aromatase inhibitor-related arthralgia.,
BMC Cancer, Vol.11, 436, 2011.

(要約): AIA tends to manifest early after starting AI, but some cases show delayed onset. The incidence was significantly lower in patients with a duration of > 10 years since LMP. When the time since LMP was short, the onset of AIA was significantly earlier after starting AI administration.
(キーワード): Breast cancer / Aged / Antineoplastic Agents, Hormonal / Aromatase Inhibitors / Arthralgia / Female / Humans / Incidence / Menopause / Middle Aged / Nitriles / Prospective Studies / Time Factors / Triazoles
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1471-2407-11-436
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21985669; ● Search Scopus @ Elsevier (PMID): 21985669; ● Search Scopus @ Elsevier (DOI): 10.1186/1471-2407-11-436

(DOI: 10.1186/1471-2407-11-436, PubMed: 21985669) Yota Yamamoto, Mayumi Ikeda, Mika Takashima, Takuya Minato, Yoshihito Furukita, Hirokazu Takechi, Junichi Seike and Akira Tangoku :
[A case of a patient with stage IVa esophageal cancer surviving over 4 years by combination chemotherapy with docetaxel,5 -FU and cisplatin, without operation].,
Japanese Journal of Cancer and Chemotherapy, Vol.38, No.8, 1321-1324, 2011.

(要約): A male patient in his 50s was found to have lower thoracic advanced esophageal squamous cell carcinoma by upper gastrointestinal endoscopy with the chief complaint of dysphagia in July 2006. CT revealed supraclavicular lymph node metastasis, and he was diagnosed as clinical stage IVa. He underwent two courses of combination chemotherapy with docetaxel, 5-FU and cisplatin(DFP therapy: docetaxel at 25mg/m / / 2 on day 1, 5-FU at 370 mg/m2 on days 1-5, and cisplatin at 7 mg/m2 on days 1-5 were repeated weekly for 4 weeks). The primary tumor disappeared and the lymph node was reduced as observed by upper gastrointestinal endoscopy and CT. After 2 courses of DFP therapy, PET-CT revealed that the primary tumor and lymph node had no new accumulation. Because he refused both operation and chemoradiotherapy, the patient underwent oral chemotherapy. In January 2010, PET-CT and upper gastrointestinal endoscopy revealed that the primary tumor relapsed. DFP therapy was performed and was effective once again. He has survived for over 4 years and 4 months without operation.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Cisplatin / Esophageal Neoplasms / Fluorouracil / Humans / Male / Middle Aged / Neoplasm Staging / Taxoids / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21829072; ● Search Scopus @ Elsevier (PMID): 21829072

(PubMed: 21829072) Akira Tangoku, Yota Yamamoto, Yoshihito Furukita, Kouichirou Kajiura, Takuya Minato and Mika Takashima :
[Mediastinoscope-assisted transhiatal esophagectomy for esophageal cancer].,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.69, No.Suppl 6, 316-321, 2011.

(キーワード): Esophageal Neoplasms / Esophagectomy / Humans / Mediastinoscopy / 胸部食道癌 / 食道切除術 / 非開胸食道抜去術 / 縦隔鏡下食堂切除術 / 低侵襲手術
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22471037; ● CiNii @ 国立情報学研究所 (CRID): 1520854805745940224; ● Summary page in Scopus @ Elsevier: 2-s2.0-84861443539

(PubMed: 22471037, CiNii: 1520854805745940224, Elsevier: Scopus) 丹黒章, 山本洋太, 古北由仁, 梶浦耕一郎, 湊拓也, 高嶋美佳 :
食道癌 -基礎・臨床研究の進歩- Ⅷ．食道癌の治療姑息的治療(ステント治療，バイパス手術),
日本臨牀, Vol.69, No.6, 380-386, 2011年.

(キーワード): 進行食道癌 / 姑息的治療 / ステント / バイパス手術 / 経口摂取
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523669555395955968; ● Summary page in Scopus @ Elsevier: 2-s2.0-84861419262

(CiNii: 1523669555395955968, Elsevier: Scopus) Yasuhiro Yuasa, Junichi Seike, Takahiro Yoshida, Hirokazu Takechi, Hiromichi Yamai, Yota Yamamoto, Yoshihito Furukita, Masakazu Goto, Takuya Minato, Takeshi Nishino, Seiya Inoue, Satoshi Fujiwara and Akira Tangoku :
Sentinel lymph node biopsy using intraoperative indocyanine green fluorescence imaging navigated with preoperative CT lymphography for superficial esophageal cancer.,
Annals of Surgical Oncology, Vol.19, No.2, 486-493, 2011.

(要約): Preoperative CTLG visualized the correct number and site of SLNs in surrounding anatomy during routine computed tomography to evaluate distant metastases. Referring to CTLG, SLNs were identified using IGFI, resulting in successful SLN navigation and saving time and cost. This method appears clinically applicable as a less-invasive method for treating superficial esophageal cancer.
(キーワード): Aged / Coloring Agents / Esophageal Neoplasms / Esophagectomy / Feasibility Studies / Fluorescence / Follow-Up Studies / Humans / Indocyanine Green / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Lymphography / Middle Aged / Neoplasm Staging / Prognosis / Sentinel Lymph Node Biopsy / Survival Rate / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1245/s10434-011-1922-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21792510; ● Search Scopus @ Elsevier (PMID): 21792510; ● Search Scopus @ Elsevier (DOI): 10.1245/s10434-011-1922-x

(DOI: 10.1245/s10434-011-1922-x, PubMed: 21792510) Misako Nakagawa, Yoshimi Bando, Taeko Nagao, Masami Morimoto, Chikako Takai, Takamasa Ohnishi, Junko Honda, Takuya Moriya, Keisuke Izumi, Masako Takahashi, Mitsunori Sasa and Akira Tangoku :
Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer.,
Anticancer Research, Vol.31, No.6, 2389-2393, 2011.

(要約): Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features. The subjects were 134 TNBC patients. Immunohistochemical staining was employed to analyze for eight biomarkers: cytokeratin 5/6 (CK5/6), epidermal growth factor receptor (EGFR), p53, Ki-67 antigen (Ki-67), E-cadherin, N-cadherin, topoisomerase 2 alpha (TOP2A) and B-cell lymphoma 2 (BCL-2), which were then correlated with the nuclear grade (NG), tumor diameter, and the presence/absence of lymph node metastasis, distant recurrence and lymphatic infiltration. Significantly more high than low NG TNBC exhibited positive p53, Ki-67, E-cadherin and TOP2A. High N-cadherin and TOP2A expression was shown significantly in TNBC with lymphatic infiltration, and N-cadherin was also significantly positively expressed in node metastasis-positive cases. EGFR and CK5/6 were positively expressed in high NG TNBC, but not significantly. Analysis for expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A is meaningful for deciding treatment strategies for TNBC.
(キーワード): Antigens, CD / Antigens, Neoplasm / Breast Neoplasms / Cadherins / DNA Topoisomerases, Type II / DNA-Binding Proteins / Female / Humans / Immunohistochemistry / Ki-67 Antigen / Middle Aged / Receptor, erbB-2 / Receptors, Estrogen / Receptors, Progesterone / Tumor Suppressor Protein p53
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21737670; ● Search Scopus @ Elsevier (PMID): 21737670

(PubMed: 21737670) 山本洋太, 高嶋美佳, 湊拓也, 古北由仁, 武知浩和, 丹黒章 :
大動脈，左主気管支に浸潤した高度進行胸部食道癌に対し，weekly DOC+low-dose FP療法が奏功し根治切除し,
四国医学雑誌, Vol.67, No.1,2, 53-58, 2011年.

(要約): A 70s woman was pointed out lower thoracic advanced esophageal squamous cell carcinoma with a chief complaint of dysphagia by upper gastrointestinal endoscopy. Computed tomography (CT)revealed that original tumor invaded to aorta and left main bronchus. Weekly docetaxel plus low-dose 5-FU and cisplatin therapy decreased the tumor. The invasion to aorta and left main bronchus was disappeared. She underwent curative esophagectomy. Main tumor had wide adherence to left main bronchus and aorta but was able to be resected. She underwent subtotal esophagectomy and gastric tube reconstruction by retrosternal route. Pathological diagnosis revealed carcinoma invaded from submucosa to adventitia and deep margin was negative(pT3). Advanced esophageal carcinoma with invasion to aorta and main bronchus is commonly treated by definitive chemoradiotherapy and hardly undergo curative resection. This case underwent curative resection after only chemotherapy. This case suggests excellent anticancer effect of the triple drug therapy.
(キーワード): invasion to another organs / esophageal cancer / neoadjuvant chemotherapy
(徳島大学機関リポジトリ): ● Metadata: 110354
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807539840

(徳島大学機関リポジトリ: 110354, CiNii: 1050865122807539840) Misako Nakagawa, Yoshimi Bando, Taeko Nagao, Chikako Takai, Takamasa Ohnishi, Junko Honda, Takuya Moriya, Keisuke Izumi, Masako Takahashi, Akira Tangoku and Mitsunori Sasa :
Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer: preliminary results.,
Breast Cancer, Vol.19, No.1, 54-59, 2011.

(要約): Diagnosis of triple-negative breast cancer (ER-negative, PgR-negative, HER2-negative; TNBC) is performed by means of immunohistological staining. HER2-negative includes HER2(0) and HER2(1+), based on differences in the staining intensity, but there have been no reports on comparison of these two types in TNBC. Accordingly, this study was designed to investigate the possible differences in the biological characteristics of HER2(0) breast cancer and HER2(1+) breast cancer in TNBC. Tissue specimens from 89 TNBC patients were immunohistochemically stained for CK5/6, EGFR, p53, Ki67, E-cadherin, TOP2A and Bcl-2. The expressions of these markers and the clinicopathological findings were compared between the HER2(0) patient group and the HER2(1+) patient group. When either CK5/6 or EGFR was positive, the specimen was judged to be the basal-like phenotype of breast cancer. The percentages of CK5/6- and/or EGFR-positive specimens in the HER2(0) and HER2(1+) groups were 44.9 and 16.8%, respectively, showing that there was a significantly greater number of basal-like phenotype patients in the HER2(0) group (p < 0.01). The percentage of E-cadherin-positive specimens in the HER2(0) group was 66.6%, which was significantly greater than the 40.0% recorded in the HER2(1+) group (p < 0.05). The respective percentages of TOP2A-positive specimens in the HER2(0) and HER2(1+) groups were 55.0 and 30.0%, and the difference was statistically significant (p < 0.05). In TNBC, HER2(0) breast cancer showed a strong tendency to include more of the basal-like phenotype compared with HER2(1+) breast cancer. The staining results indicated the possibility that HER2(0) breast cancer and HER2(1+) breast cancer have different characteristics.
(キーワード): Antigens, Neoplasm / Breast Neoplasms / Cadherins / DNA Topoisomerases, Type II / DNA-Binding Proteins / Female / Humans / Ki-67 Antigen / Middle Aged / Receptor, Epidermal Growth Factor / Receptor, erbB-2 / Receptors, Estrogen / Receptors, Progesterone / Tumor Markers, Biological / Tumor Suppressor Protein p53
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-011-0265-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21465226; ● CiNii @ 国立情報学研究所 (CRID): 1573668925529609856; ● Search Scopus @ Elsevier (PMID): 21465226; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-011-0265-6

(DOI: 10.1007/s12282-011-0265-6, PubMed: 21465226, CiNii: 1573668925529609856) Abdellah Hamed Khalil Ali, Hiromitsu Takizawa, Kazuya Kondo, Yasushi Nakagawa, Hiroaki Toba, Narmisheekh Khasag, Koichiro Kenzaki, Shoji Sakiyama, Hamdy Ali Mohammadien, Essam Ahmed Mokhtar and Akira Tangoku :
Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer.,
The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 46-55, 2011.

(要約): To evaluate the accuracy of fluorescence bronchoscopy by precise histological analysis of the photodynamic therapy (PDT) treated lesions.
(徳島大学機関リポジトリ): ● Metadata: 75865
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.58.46
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21372486; ● Search Scopus @ Elsevier (PMID): 21372486; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.46

(徳島大学機関リポジトリ: 75865, DOI: 10.2152/jmi.58.46, PubMed: 21372486) Junichi Seike, Akira Tangoku, Yasuhiro Yuasa, Hiroshi Okitsu, Yukikiyo Kawakami and Masayuki Sumitomo :
The effect of nutritional support on the immune function in the acute postoperative period after esophageal cancer surgery: total parenteral nutrition versus enteral nutrition., --- Enteral nutrition (EN) is now used more frequently than total parenteral nutrition (TPN) for nutritional support after resection for esophageal cancer. But consensus regarding which type of nutrition should be used does not exist. We studied the effect of TPN and EN on patients' nutritional status and immune function in the immediate postoperative period after esophageal cancer resection. ---,
The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 75-80, 2011.

(要約): Enteral nutrition (EN) is now used more frequently than total parenteral nutrition (TPN) for nutritional support after resection for esophageal cancer. But consensus regarding which type of nutrition should be used does not exist. We studied the effect of TPN and EN on patients' nutritional status and immune function in the immediate postoperative period after esophageal cancer resection. We enrolled 30 patients (27 men and 3 women) who underwent subtotal esophagectomy. The patients were randomly assigned to TPN or EN group. Either TPN or EN was begun on postoperative day 1. On postoperative days 1, 3, and 7, three endpoints were measured: albumin, C-reactive protein, and Th1/Th2 balance. All patients completed the study. Anastomotic leaks occurred in 6 patients in the TPN group and 7 patients in the EN group. Albumin, Th1/Th2 balance, and C-reactive protein did not differ between the groups. Th1/Th2 balance was not different regardless of the preoperative treatment or complications. No differences in immune function, nutritional state, or inflammatory response were seen between patients supported with TPN and those supported with EN. The results of our study suggest that perioperative nutritional support can be safely performed either with TPN or EN.
(キーワード): Aged / C-Reactive Protein / Enteral Nutrition / Esophageal Neoplasms / Female / Humans / Male / Middle Aged / Parenteral Nutrition, Total / Postoperative Care / Postoperative Period / Serum Albumin / Th1 Cells / Th2 Cells
(徳島大学機関リポジトリ): ● Metadata: 75864
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.58.75
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21372490; ● Search Scopus @ Elsevier (PMID): 21372490; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.75

(徳島大学機関リポジトリ: 75864, DOI: 10.2152/jmi.58.75, PubMed: 21372490) Khalil Abdellah Hamed Ali, Hiromitsu Takizawa, Kazuya Kondo, Hisashi Matsuoka, Hiroaki Toba, Yasushi Nakagawa, Koichiro Kenzaki, Shoji Sakiyama, Soji Kakiuchi, Yoshitaka Sekido, Saburo Sone and Akira Tangoku :
5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor.,
Lung Cancer, 2011.

(要約): BACKGROUND: It is known that endogenously synthesized protoporphyrin IX (PpIX) following the administration of 5-aminolevulinic acid (5-ALA) is an effective photosensitizer for photodynamic diagnosis (PDD). We tested in vivo and in vitro susceptibility of human lung cancer and mesothelioma cells to photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) as a photosensitizer. METHODS: Human lung cancer cell lines A549, Ma44-3, FT821 and human mesothelioma cell lines MSTO-211H, NCI-H290, Y-MESO-14 were incubated with 0.03% 5-ALA for 4h. After incubation, protoporphyrin IX (PpIX) fluorescence was detected using a fluorescence microscope. Pleural carcinosis was induced in severe combined immunodeficiency disease mice using the previous cell lines to test the efficacy of PDD in vivo. The mice were sacrificed 4h after oral administration of 400mg/kg of 5-ALA. We counted the visible tumors under white light then fluorescence light. RESULTS: In vitro, clear red fluorescence was observed in all cell lines. The mean fluorescence intensity was stronger in A549 and FT821 cells than Ma44-3 cells (165.59±26.49, 157.62±18.93 vs. 104.01±17.58). Also, MSTO-211H and NCI-H290 cells had stronger fluorescence intensity than Y-MESO-14 cells (142.51±26.85, 165.16±12.91 vs. 92.31±8.69). In vivo, the tumor detection rate of fluorescence diagnosis was 1.1-4.5 times higher than that of white light. The mean number of metastases detected by the PDD was significantly higher than that of white light for FT821 (p=0.004), Ma44-3 (p=0.006) and Y-MESO-14 cell lines (p=0.005), but not for A549, NCI-H290 and MSTO-211H cell lines. Small lesions were detected by fluorescence diagnosis even though the lesions were invisible macroscopically under white light. CONCLUSION: Our results suggest the possibility of clinical application of fluorescence diagnosis with intrapleural malignant tumors.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2011.01.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21353719; ● Search Scopus @ Elsevier (PMID): 21353719; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2011.01.031

(DOI: 10.1016/j.lungcan.2011.01.031, PubMed: 21353719) Abdellah H. K. Ali, Kazuya Kondo, Toshiaki Namura, Yoshitaka Senba, Hiromitsu Takizawa, Yasushi Nakagawa, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure.,
Molecular Carcinogenesis, Vol.50, No.2, 89-99, 2010.

(要約): Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). In the present study, we examined epigenetic changes in chromate lung cancers. Nested-methylation-specific PCR was employed in studying the methylation of CpG islands in the APC, MGMT, hMLH1 genes in 36 chromate lung cancers and 25 nonchromate lung cancers. Methylation in chromate lung cancers was detected at 86% for APC, 20% for MGMT, and 28% for hMLH1. Whereas, it occurred at lower frequencies in nonchromate lung cancers, particularly in APC (44%) and hMLH1 (0%) genes. Our previous study showed that methylation of p16 gene in chromate lung cancer and nonchromate lung cancer was 33% and 26%, respectively. The mean methylation index (MI), a reflection of the overall methylation status, was significantly higher in chromate lung cancers than nonchromate lung cancers (0.41 vs. 0.21, P=0.001). Methylation of multiple genes (particularly hMLH1, p16, and APC genes) had experienced more than 15 yr of chromate exposure in chromate lung cancer (MI: <15 yr; 0.19, ≥ 15 yr, 0.42). There is a significant correlation of p16 and hMLH1 methylation with the expressional decrease or loss of the corresponding gene products (P=0.037 and 0.024) respectively, and an inverse correlation between APC and MGMT methylation (P = 0.014). This study provides a novel evidence for the chromium carcinogenesis that chromate lung cancer is linked to the progressive methylation of some tumor suppressor genes, which may be related to genomic instability.
(キーワード): Adaptor Proteins, Signal Transducing / Adult / Aged / Chromates / CpG Islands / DNA Methylation / DNA Modification Methylases / DNA Repair Enzymes / Epigenesis, Genetic / Genes, APC / Genes, Tumor Suppressor / Humans / Lung Neoplasms / Middle Aged / Nuclear Proteins / Occupational Diseases / Occupational Exposure / Promoter Regions, Genetic / Tumor Suppressor Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mc.20697
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21229606; ● Search Scopus @ Elsevier (PMID): 21229606; ● Search Scopus @ Elsevier (DOI): 10.1002/mc.20697

(DOI: 10.1002/mc.20697, PubMed: 21229606) 丹黒章, 山本洋太, 古北由仁, 湊拓也, 兼松美幸, 高嶋美佳 :
特集:術前・術後に要注意併存疾患の手術リスクと対策 Ⅰ．基礎疾患併存例の手術 7．自己免疫疾患,
外科, Vol.72, No.9, 945-949, 2010年.

(キーワード): 自己免疫疾患 / 免疫力低下 / 日和見感染 / クリーゼ
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238029204736

(CiNii: 1390564238029204736) 河北直也, 鳥羽博明, 先山正二, 澤田徹, 山本洋太, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
左上下肺静脈が共通幹を形成していた肺癌の2例,
胸部外科, Vol.63, No.10, 915-918, 2010年.

(要約): A 69-year-old man and a 53-year-old man with lung cancer of left upper lobe underwent pulmonary resection. A preoperative chest computed tomography (CT) scan showed the left superior and inferior pulmonary veins forming a common trunk. In the former case, the common trunk was misidentified as the superior pulmonary vein. The latter was recognized preoperatively by using 3-dimensional CT, and successfully performed left superior segmentectomy. This variation type is surgically important because of a potential risk of intraoperative bleeding and damage to pulmonary circulation during pulmonary resection.
(キーワード): Aged / Cardiovascular Abnormalities / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Pulmonary Veins / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20845705; ● Search Scopus @ Elsevier (PMID): 20845705

(PubMed: 20845705) Hiroaki Toba, Kazuya Kondo, Hideki Otsuka, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Diagnosis of the presence of lymph node metastasis and decision of operative indication using fluorodeoxyglucose-positron emission tomography and computed tomography in patients with primary lung cancer.,
The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 305-313, 2010.

(要約): PET/CT is superior to CT scan in lymph node staging. However, because the false-positive rate is high in PET-positive lymph nodes measuring less than 1 cm in diameter, we think that clinical background should be considered and other modalities or histological examinations should be undertaken if necessary. J. Med. Invest. 57: 305-313, August, 2010.
(キーワード): Aged / Diagnostic Errors / Female / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Lymph Node Excision / Lymphatic Metastasis / Male / Middle Aged / Neoplasm Staging / Positron-Emission Tomography / Radiopharmaceuticals / Retrospective Studies / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 73983
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.57.305
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847531; ● Search Scopus @ Elsevier (PMID): 20847531; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.305

(徳島大学機関リポジトリ: 73983, DOI: 10.2152/jmi.57.305, PubMed: 20847531) Kenji Okazaki, Akira Tangoku, Tadaoki Morimoto, Ryosuke Kotani, Keigo Hattori, Emiko Yasuno, Masatake Akutagawa and Yohsuke Kinouchi :
Basic study of a diagnostic modality employing a new electrical impedance tomography (EIT) method for noninvasive measurement in localized tissue,
The Journal of Medical Investigation : JMI, Vol.57, No.3,4, 205-218, 2010.

(要約): The objective of this study is to develop a device for noninvasive local tissue electrical impedance tomography (EIT) using divided electrodes with guard electrodes and to validate its effectiveness using bioequivalent phantoms. For this purpose, we prepared a measurement device and bioequivalent phantoms, measured the electrical characteristics of the phantoms, and validated the method using the phantoms. Monolayer phantoms mimicking the brain and muscle and bilayer phantoms consisting of muscle and brain layers were prepared. The relative differences between the measured electrical conductivities of the monolayer brain and muscle phantoms and the true values determined by the 4-electrode method were both less than 10%. The relative differences between the measured and true values in the bilayer phantoms were less than 20% in both layers. The biological impedance measurement device that we developed was confirmed to be effective for impedance measurement in bilayer phantoms with different electrical impedances. To develop a device for the early diagnosis of breast diseases, the development of a multi-layer phantom and demonstration of the effectiveness of the device for its examination are necessary. If the device that we developed makes impedance measurement in breast tumors possible, it may be used as a new diagnostic modality for breast diseases.
(キーワード): 脳 (brain) / Breast Neoplasms / Electric Impedance / Electrodes / Equipment Design / Female / Humans / Muscles / Phantoms, Imaging / 断層 (tomography)
(徳島大学機関リポジトリ): ● Metadata: 70726
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.57.205
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847519; ● Search Scopus @ Elsevier (PMID): 20847519; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.205

(徳島大学機関リポジトリ: 70726, DOI: 10.2152/jmi.57.205, PubMed: 20847519) 監﨑孝一郎, 先山正二, 富本英樹, 鳥羽博明, 中川靖士, 滝沢宏光, 近藤和也, 曽根三郎, 丹黒章 :
胸部外科の指針高齢者原発性肺癌における臨床的検討,
胸部外科, Vol.63, No.7, 519-526, 2010年.

(要約): We clinically reviewed 33 surgery patients and 15 non-surgery patients aged 80 years or older with primary lung cancer treated at our hospital. The surgery group consisted of 21 males and 12 females (82.0 +/- 1.9 years old). The surgical procedures were 1 pneumonectomy, 19 lobectomies (1 bronchoplasty), 4 segmentectomies and 9 partial resections. The cancer types were 17 adenocarcinomas, 14 squamous cell carcinomas and 2 others. The stagings were 24 in stage I, 4 in stage II and 5 in stage III. There were no direct surgical deaths within 30 days post operatively. There have been 9 other disease-related deaths to date (27%). The non-surgery group consisted of 9 males and 6 females (81.7 +/- 1.5 years old). Treatment procedures consisted of radiationtherapy in 11, chemotherapy in 2 and best supportive care in 3. The cancer types were 2 adenocarcinomas, 11 squamous cell carcinomas and 2 others. The stagings were 7 in stage I, 4 in stage II and 4 in stage III. There have been 3 other disease-related deaths to date (20%). We must carefully select the therapeutic approach for elderly lung cancer patients, because the other disease-related death rates of both groups were high. The 5-year survival rate of stage I patients in the surgical group was relatively good (60.2%). There were long-term survival (7 5-year survivors) in the surgical group. Since there were some cases of radiation pneumonia in the group receiving radiation therapy, it would be better to perform surgery for elderly patients with lung cancer, especially those with stage I disease. For elderly patients, it is important to consider quality of life as well as the survival rate.
(キーワード): Age Factors / Aged / Aged, 80 and over / Female / Humans / Lung Neoplasms / Male / Pneumonectomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20662228; ● Summary page in Scopus @ Elsevier: 2-s2.0-77956070239

(PubMed: 20662228, Elsevier: Scopus) 丹黒章, 山本洋太, 古北由仁, 森本雅美, 兼松美由紀, 高嶋美佳 :
特集●食道癌手術―困難症例・偶発症対処の秘策-高度胸膜癒着,
手術, Vol.64, No.7, 939-944, 2010年.

(キーワード): 食道癌手術 / 開胸術 / 高度胸膜癒着 / 胸腔鏡 / 縦隔鏡
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521136280130644352

(CiNii: 1521136280130644352) 丹黒章, 清家純一, 山本洋太, 古北由仁, 藤原聡史, 井上聖也, 兼松美幸, 森本雅美, 高嶋美佳 :
《特集画像による癌深達度診断;外科治療方針決定のために》食道癌,
消化器外科, Vol.33, No.6, 1005-1014, 2010年. Takahiro Yoshida, Jun-ichi Seike, Takanori Miyoshi, Yamai Hiromichi, Hirokazu Takechi, Yuasa Yasuhiro, Yoshihito Furukita, Yota Yamamoto, Atsushi Umemoto and Akira Tangoku :
Preoperative chemotherapy with weekly docetaxel plus low-dose cisplatin and 5-fluorouracil for stage II/III squamous cell carcinoma of the esophagus,
Esophagus, Vol.7, No.2, 95-100, 2010.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-010-0234-8
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-77954768652

(DOI: 10.1007/s10388-010-0234-8, Elsevier: Scopus) 森本忠興, 長尾妙子, 岡崎憲二, 吉良美砂子, 森本雅美, 中川靖, 丹黒章 :
乳癌の診療Up to date乳癌検診の現状,
外科治療, Vol.101, No.6, 637-645, 2009年.

(キーワード): 乳癌 (breast cancer) / 検診 / 死亡率減少 / マンモグラフィ / 精度管理
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522543654762461440

(CiNii: 1522543654762461440) Taeko Nagao, Misako Kira, Masako Takahashi, Junko Honda, Toshiyuki Hirose, Akira Tangoku, Hitoshi Zembutsu, Yusuke Nakamura and Mitsunori Sasa :
Serum estradiol should be monitored not only during the peri-menopausal period but also the post-menopausal period at the time of aromatase inhibitor administration.,
World Journal of Surgical Oncology, Vol.7, 88, 2009.

(要約): BACKGROUND: Aromatase inhibitor (AI) therapy is being extensively used as postoperative adjuvant therapy in patients with hormone receptor-positive postmenopausal breast cancer. On the other hand, it has been reported that ovarian function was restored when AI was administered to patients who had undergone chemical menopause with chemotherapy or tamoxifen. However, there have been no reports of comprehensive monitoring of estradiol (E2) in breast cancer patients with ordinary menopause who were being administered AI. PATIENTS AND METHODS: Beginning in March 2008, regular monitoring of the serum levels of E2, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was performed for 66 postmenopausal breast cancer patients who had been started on AI therapy. For this study, we chose anastrozole as the AI. The assays of those hormones were outsourced to a commercial clinical laboratory. RESULTS: In 4 of the 66 patients the serum E2 level was decreased at 3 months but had then increased at 6 months, while in 2 other patients E2 was decreased at both 3 and 6 months but had increased at 9 months. CONCLUSION: The results indicate that, in some breast cancer patients with ordinary menopause, E2 rebounds following AI therapy. In the future, E2 monitoring should be performed for a larger number of patients being administered AI therapy. TRIAL REGISTRATION: Our trial registration number is 19-11-1211.
(キーワード): Antineoplastic Agents, Hormonal / Aromatase Inhibitors / Breast Neoplasms / Chemotherapy, Adjuvant / Estradiol / Female / Follicle Stimulating Hormone / Humans / Luteinizing Hormone / Nitriles / Perimenopause / Postmenopause / Triazoles
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1477-7819-7-88
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19909552; ● Search Scopus @ Elsevier (PMID): 19909552; ● Search Scopus @ Elsevier (DOI): 10.1186/1477-7819-7-88

(DOI: 10.1186/1477-7819-7-88, PubMed: 19909552) 徳光幸生, 山本達人, 北村義則, 安藤静一郎, 都志見久令男, 丹黒章 :
肺癌根治術後の胸部中部食道癌に対し縦隔鏡下食道切除術を施行した1例,
癌と化学療法, Vol.36, No.12, 2445-2447, 2009年.

(要約): We herein report a case of thoracic esophageal cancer operated on by mediastinoscope-assisted transhiatal esophagectomy after a right upper lobectomy for primary lung cancer. A 70-year-old male with non-small-cell lung cancer (T4N2M0, cStage III B) underwent chemo-radiation therapy followed by an upper lobectomy of the right lung with mediastinal lymph node dissection. The lung cancer histologically showed complete remission (CR), and no recurrence has been shown. Five years after the operation of lung cancer, esophageal cancer (T3N0M0, cStage II) was endoscopically detected in this patient. Partial remission was obtained after neoadjuvant FP chemotherapy for esophageal cancer. Therefore, mediastinoscope-assisted transhiatal esophagectomy was performed in consideration of a history of a right thoracotomy and of pulmonary dysfunction. Preventive tracheostomy was performed because of recurrent nerve paralysis, but no other severe postoperative complication has developed in this case. Histopathological findings showed a well differentiated squamous cell carcinoma (pT3 (Ad), pN0, M0, pStage II), with involvement at resection margin. He was alive for 11 months after the operation for esophageal cancer, although a local recurrence was observed. There are still many problems remained of the treatment for esophageal cancer patients who had previously undergone a radical operation for lung cancer. However, mediastinoscope-assisted transhiatal esophagectomy may become a procedure for surgical approach if it seems to be difficult to approach the esophageal cancer by thoracotomy again.
(キーワード): Aged / Carcinoma, Squamous Cell / Esophageal Neoplasms / Esophagectomy / Humans / Lung Neoplasms / Male / Mediastinoscopy / Neoplasms, Multiple Primary / Pneumonectomy / Remission Induction / Tracheostomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20037451; ● Search Scopus @ Elsevier (PMID): 20037451

(PubMed: 20037451) Hiroaki Toba, Kazuya Kondo, Koichiro Kenzaki, Takanori Miyoshi, Shoji Sakiyama and Akira Tangoku :
Late pulmonary metastases from malignant melanoma of the left planta.,
General Thoracic and Cardiovascular Surgery, Vol.57, No.10, 558-561, 2009.

(要約): We report a patient treated for malignant melanoma of the left planta who developed pulmonary metastases after a disease-free interval of 10 years. Metastatectomy was performed after observing progress for 12 months. However, 18 months later, pretracheal and right axillary lymph node metastases occurred. Because pulmonary metastasis from malignant melanoma may occur after 10 years or more, we observe patients carefully. If it does occur, an operation should be considered under limited indications. We should also recognize that recurrence may occur within a short interval after metastatectomy as well.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-009-0438-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19830522; ● Search Scopus @ Elsevier (PMID): 19830522; ● Search Scopus @ Elsevier (DOI): 10.1007/s11748-009-0438-9

(DOI: 10.1007/s11748-009-0438-9, PubMed: 19830522) Takao Tamesa, Norio Iizuka, Naohide Mori, Toshimasa Okada, Norikazu Takemoto, Akira Tangoku and Masaaki Oka :
High serum levels of vascular endothelial growth factor after hepatectomy are associated with poor prognosis in hepatocellular carcinoma.,
Hepato-Gastroenterology, Vol.56, No.93, 1122-1126, 2009.

(要約): BACKGROUND/AIMS: Vascular endothelial growth factor (VEGF) reportedly affects the metastatic potential of tumors. We investigated in patients whether association exits between perioperative serum VEGF levels and recurrence of hepatocellular carcinoma (HCC). METHODOLOGY: Thirty-two patients who underwent curative resection for HCC were enrolled in this study. Blood samples were obtained at 6 points during the perioperative period: preoperative day and, postoperative days 1, 2, 3, 7 and 14). Serum VEGF levels were measured by enzyme-linked immunosorbent assay. We divided the 32 hepatocellular carcinoma patients into a high VEGF group (preoperative serum level > or = 100 pg/ ml, n = 10) and a low VEGF group (preoperative serum level < 100 pg/ml, n = 22). RESULTS: During a median follow-up period of 27.1 months, the cancer recurred in 20 of the 32 patients. Disease-free survival in the high VEGF group was significantly poorer than that in the low VEGF group (p < 0.05). Serum VEGF levels in the high VEGF group remained significantly higher than those in the low VEGF group after hepatectomy (p < 0.05). Serum VEGF levels in the recurrent group were also significantly higher than those in the non recurrent group at preoperative day, postoperative days 2, 3 and 7 (p < 0.05). CONCLUSIONS: High serum VEGF levels during perioperative period may be a risk factor for intrahepatic recurrence after complete resection for HCC.
(キーワード): Analysis of Variance / Carcinoma, Hepatocellular / Enzyme-Linked Immunosorbent Assay / Female / Hepatectomy / Humans / Liver Function Tests / Liver Neoplasms / Male / Middle Aged / Neoplasm Recurrence, Local / Predictive Value of Tests / Prognosis / Proportional Hazards Models / Risk Factors / Statistics, Nonparametric / Survival Rate / Tumor Markers, Biological / Vascular Endothelial Growth Factor A
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19760954; ● Search Scopus @ Elsevier (PMID): 19760954

(PubMed: 19760954) Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model.,
Oncology Reports, Vol.22, No.1, 17-21, 2009.

(要約): Fluorescence diagnosis of lymph node metastasis of non-small cell lung cancer has not been reported previously. This study was conducted to evaluate the feasibility of fluorescence detection using 5-aminolevulinic acid and mono-L-aspartyl chlorine e6 for lymph node metastasis in a lung cancer mouse model. Human lung cancer cell line Ma44-3, which forms metastatic lymph nodes in the mediastinum, was injected into the left lungs of 6 severe combined immunodeficiency disease mice. Two weeks after implantation, 2 groups of 3 mice received oral administration of 5-aminolevulinic acid (100 mg/kg) or intraperitoneal administration of mono-L-aspartyl chlorine e6 (5 mg/kg). Both lungs and mediastinal organs were removed en-bloc and illuminated with blue light (405 nm) to evaluate the detectability of lung tumors and metastatic lymph nodes in the mediastinum. These organs were evaluated histopathologically. Clear red fluorescence was observed in the lung tumors of all mice. Metastatic lymph nodes had formed in 5 of 6 mice and were detected by fluorescent detection in all 5 mice even though one of the lymph nodes was invisible macroscopically under white light. In conclusion, fluorescence diagnosis of lymph node metastasis is possible in a mouse model. The successful result with small lymph node metastasis suggests the possibility of clinical application.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or_00000400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19513499; ● Search Scopus @ Elsevier (PMID): 19513499; ● Search Scopus @ Elsevier (DOI): 10.3892/or_00000400

(DOI: 10.3892/or_00000400, PubMed: 19513499) 片山和久, 沖津宏, 田中麻美, 山村陽子, 湊拓也, 丹黒章 :
びまん性食道痙攣症に対して腹腔鏡下Heller-Dor手術を施行した1例,
手術, Vol.63, No.7, 1-5, 2009年.

(キーワード): びまん性食道痙攣症 / diffuse esophageal spasm / Heller-Dor手術
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1523951029520249088

(CiNii: 1523951029520249088) 丹黒章, 清家純一, 山本洋太, 古北由仁, 藤原聡史, 井上聖也, 森本雅美 :
ここまできた食道疾患の内視鏡化治療・外科手術内視鏡外科食道癌に対する縦隔鏡下食道切除術,
外科治療, Vol.100, No.6, 790-795, 2009年.

(キーワード): 食道癌 / 縦隔鏡 / 食道切除術 / 低侵襲手術
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522543654762429568

(CiNii: 1522543654762429568) 山井礼道, 吉田卓弘, 鳥羽博明, 吉良美砂子, 滝沢宏光, 丹黒章 :
経口フッ化ピリミジン系抗癌剤の補助療法にて3年の長期生存を得ている甲状腺未分化癌の1例,
癌と化学療法, Vol.36, No.6, 1021-1024, 2009年.

(要約): We report a case of anaplastic carcinoma of the thyroid administered peroral fluorinated pyrimidine, providing longterm survival during three years. Three years ago, a 70-year-old woman diagnosed with anaplastic carcinoma of the thyroid was admitted for chemoradiation therapy after tumor resection and tracheostomy. The tumor was confirmed to remain on the margin of resected specimens by postoperative histopathology. Combination chemotherapy, including docetaxel, 5-fluorouracil, cisplatin, and radiotherapy, was performed for four weeks. After completion of radiotherapy, CT scan showed residual tumor and lytic clavicular bone findings. But the patient did not desire the same heavy chemotherapy, wishing rather to undergo chemotherapy as an outpatient, if possible. She received chemotherapy with S-1 which was peroral fluorinated pyrimidine for 9 months. In this period, PET-CT showed that accumulation of FDG and lytic clavicular bone findings were continuously confirmed. She was changed to tegafur-uracil(UFT)from S-1, because of myelosuppression. She is alive at this writing in good physical condition. CT shows no tumor growth and no remote metastasis.
(キーワード): Administration, Oral / Aged / Antimetabolites, Antineoplastic / Antineoplastic Combined Chemotherapy Protocols / Carcinoma / Drug Combinations / Female / Humans / Oxonic Acid / Tegafur / Thyroid Neoplasms / Uracil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19542729; ● Search Scopus @ Elsevier (PMID): 19542729

(PubMed: 19542729) 丹黒章, 長尾妙子, 吉良美砂子, 岡崎憲二, 澤田徹, 河北直也 :
乳房温存手術∼CT lymphographyによるセンチネルリンパ節転移診断と鏡視下乳房温存手術手術特集「若い外科医に伝えたい私の手術手技」,
手術, Vol.63, No.6, 867-874, 2009年.

(キーワード): 乳房温存手術 / センチネルリンパ節 / CT lymphography
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521699230743327488

(CiNii: 1521699230743327488) M Yoshida, Shoji Sakiyama, Koichiro Kenzaki, Hiroaki Toba, K Uyama, M Takehisa, Kazuya Kondo and Akira Tangoku :
Functional evaluation of pallid mice with genetic emphysema.,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.89, No.7, 760-768, 2009.

(要約): Studies on pallid mice models of genetic emphysema have conventionally focused on morphological or biochemical evaluations. However, it is important to consider the functional aspects. We evaluated the exercise capacity and respiratory function in male pallid mice and male C57BL/6J mice at 3, 6, 12, and 15 months of age. The functional evaluations were conducted using a treadmill and a pulmonary function analysis device. The morphology of the lungs was analyzed on the basis of mean linear intercept (Lm) values. The body weights of the pallid mice at 12 and 15 months were significantly lower than those of the age-matched C57BL/6J mice. The pallid mice showed deterioration in exercise capacity from 6 months, as indicated by the trends in running distance. At 6, 12, and 15 months, the pallid mice showed significantly higher pulmonary compliance and significantly lower forced expiratory volume in 20 ms (FEV(20 ms))/vital capacity (VC) values in comparison with the corresponding values for the C57BL/6J mice. In the morphological analysis of the pallid mice, emphysema was detected from 12 months, and the mice showed a significantly larger Lm at 12 months. The exercise capacity and lung function in the pallid mice significantly deteriorated from 6 months, at which time no pathological changes in the lung were detected. The deterioration in the exercise capacity and pulmonary function preceded the microscopic morphological changes.Laboratory Investigation advance online publication, 20 April 2009; doi:10.1038/labinvest.2009.34.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/labinvest.2009.34
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19381131; ● Search Scopus @ Elsevier (PMID): 19381131; ● Search Scopus @ Elsevier (DOI): 10.1038/labinvest.2009.34

(DOI: 10.1038/labinvest.2009.34, PubMed: 19381131) Takahiro Yoshida, Takanori Miyoshi, Jun-Ichi Seike, Hiromichi Yamai, Hirokazu Takechi, Yasuhiro Yuasa and Akira Tangoku :
Gene expression changes in a chemoresistant model with human esophageal cancer xenografts using cDNA microarray.,
Anticancer Research, Vol.29, No.4, 1163-1168, 2009.

(要約): BACKGROUND: 5-Fluorouracil (5-FU) and cisplatin combined chemotherapy (FP) is commonly used for esophageal cancer. Acquired resistance needs to be overcome to improve the chemotherapeutic effect. MATERIALS AND METHODS: The FP-resistant xenograft model using severe combined immunodeficient (SCID) mice was established as an acquired resistance model. RNA was extracted pretreatment, at the onset of the anticancer effect, during the most effective, and regrowth period in the FP administration group and during the mid-progressive period and the far advanced period in the control group. A microarray was applied to explore gene expression changes. RESULTS: The data set containing up-regulated genes in the regrowth period was uploaded into Ingenuity Pathway Analysis. The expression change profiles suggested that activation of not only 5-FU- and cisplatin-specific genes, but also the Phosphoinositide 3-kinase (PI3K)/AKT signal were associated with FP resistance. CONCLUSION: A xenograft model using SCID mice with esophageal cancer cells would monitor gene changes during treatment and regrowth.
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19414360; ● Search Scopus @ Elsevier (PMID): 19414360

(PubMed: 19414360) Hiromichi Yamai, Naruhiko Sawada, Takahiro Yoshida, Junnichi Seike, Hiromitsu Takizawa, Koichiro Kenzaki, Takanori Miyoshi, Kazuya Kondo, Yoshimi Bando, Yoshinari Ohnishi and Akira Tangoku :
Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo.,
International Journal of Cancer, Vol.125, No.4, 952-960, 2009.

(要約): The antineoplastic effects of combinations of anticancer drugs (5-fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by the WST-8 (2-(2-methoxy- 4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) assay in vitro and by an animal model in vivo. Triterpenes and JAE showed additive and synergistic cytotoxic effects, respectively, on esophageal squamous carcinoma cells (YES-2cells) by combinational use of 5-fluorouracil. JAE and 5-fluorouracil induced cell cycle arrest at G2/M phase and at S phase, respectively, and caused apoptosis in YES-2 cells. A new animal model of esophageal cancer causing tumor colonization of the peritoneal cavity and producing bloody ascites was made by injecting YES-2 cells into the peritoneal cavity of a severe combined immunodeficiency mouse. In this model, 5-fluorouracil inhibited colonization of tumor cells in the peritoneum. The addition of JAE to 5-fluorouracil augmented the suppression of experimental metastasis of the peritoneum. The numbers of peritoneal nodules of more than 2 mm in diameter in mice treated with 5-fluorouracil and JAE were less than those in mice treated with 5-fluorouracil alone or JAE alone. These results suggest that triterpenes, especially JAE, are effective supplements for enhancing the chemotherapeutic effect of 5-fluorouracil on esophageal cancer. (c) 2009 UICC.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ijc.24433
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19462449; ● Search Scopus @ Elsevier (PMID): 19462449; ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.24433

(DOI: 10.1002/ijc.24433, PubMed: 19462449) Hiroaki Toba, Kazuya Kondo, Hiromitsu Takizawa and Akira Tangoku :
Recurrent thymoma with a pleural dissemination invading the intervertebral foramen.,
European Journal of Cardio-Thoracic Surgery, Vol.35, No.5, 917-919, 2009.

(要約): We report a rare case of recurrent thymoma with pleural dissemination invading the intervertebral foramen. A woman with Masaoka's stage IVa thymoma with myasthenia gravis (MG) underwent macroscopically complete resection. After 45 months, she developed back pain. Computed tomography (CT) of the chest demonstrated a mass in the right thoracic cavity invading the intervertebral foramen between thoracic vertebrae 10 and 11. She underwent complete resection of the tumor and postoperative radiotherapy. The resected specimen was histologically diagnosed as a pleural dissemination from thymoma. There has been no local recurrence.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejcts.2009.01.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19269845; ● Search Scopus @ Elsevier (PMID): 19269845; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejcts.2009.01.036

(DOI: 10.1016/j.ejcts.2009.01.036, PubMed: 19269845) 鳥羽博明, 先山正二, 森本雅美, 滝沢宏光, 監﨑孝一郎, 近藤和也, 坂東良美, 丹黒章 :
肺多形癌の3切除例,
胸部外科, Vol.62, No.3, 202-206, 2009年.

(要約): We experienced 3 resected cases of pleomorphic carcinoma of the lung. Each cases were 74-year-old man (case 1), 74-year-old woman (case 2) and 69-year-old man (case 3). Two patients (case 1 and 2) were histologically diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with giant cell carcinoma. One patient (case 3) was similarly diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with adenocarcinoma and squamous cell carcinoma. Although lymph nodes metastasis were not recognized in all patients, invasion to vessels were recognized in 2 patients (case 1 and 3). In one patient (case 1), recurrence was recognized at contralateral side 1 month after surgery and he died of other disease 2 months after surgery. The other 2 patients were alive without recurrence 24 and 5 months after surgery. Recently it is reported that recurrence is recognized at early phase after surgery and prognosis is poor in a case with vessel invasions in spite of pathological NO state. Since one patient (case 3) had nonmetastatic lymph nodes with vessel invasions, careful observation is considered to be necessary.
(キーワード): Aged / Aged, 80 and over / Carcinoma / Diagnostic Imaging / Fatal Outcome / Female / Humans / Lung Neoplasms / Male / Neoplasm Staging / Treatment Outcome
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19280950; ● Search Scopus @ Elsevier (PMID): 19280950

(PubMed: 19280950) 丹黒章, 清家純一, 山本洋太, 古北由仁, 藤原聡, 井上聖也, 兼松美幸, 森本雅美, 高嶋美佳 :
食道癌特集●画像によるがん深達度診断;外科治療方針決定のために,
消化器外科, Vol.33, No.6, 1005-1014, 2009年. 丹黒章, 長尾妙子, 吉良美砂子, 岡﨑憲二, 森本雅美 :
最新乳房腫瘍の手技・手術のすべてII.切除胸筋温存乳房切除術,
手術, Vol.60, No.10, 1431-1437, 2009年. 原田雅史, 瀧雅子, 福家由佳里, 久保均, 西谷弘, 丹黒章 :
乳腺proton MRSの測定方法と有用性:基礎から将来性まで,
日獨医報, Vol.54, No.1, 60-67, 2009年. Tadaoki Morimoto, Taeko Nagao, Kenji Okazaki, Misako Kira, Yasushi Nakagawa and Akira Tangoku :
Current status of breast cancer screening in the world.,
Breast Cancer, Vol.16, No.1, 2-9, 2008.

(要約): The mortality associated with breast cancer is decreasing in Europe and the United States. There are various reasons for these trends, including an increase in detection of early-stage breast cancers due to increased use of mammographic screening and the establishment of standardized systemic treatments based on evidence-based medicine. However, in Japanese women, both the morbidity and the mortality of breast cancer are increasing. In this manuscript, we describe the current status of mammographic screening in Europe and the United States, and the status of breast cancer screening in Japan. Quality control systems are also introduced, and the need for practical measures, such as implementation of quality control systems aimed at improving the cancer screening rate (with a target of 50%) and population-based screening (organized screening), based on the Cancer Control Act, is described. Current countermeasures for dense breasts in women in their 40s, both overseas and in Japan, are also described, together with discussions of the diagnostic capability of digital mammography, the usefulness of screening combined with computer-aided diagnosis, and the current status of screening using MRI in Europe and the United States.
(キーワード): Breast Neoplasms / 画像診断 (diagnostic imaging) / Female / Humans / Image Interpretation, Computer-Assisted / Mass Screening / Quality Control
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-008-0077-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18841333; ● Search Scopus @ Elsevier (PMID): 18841333; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-008-0077-5

(DOI: 10.1007/s12282-008-0077-5, PubMed: 18841333) 監﨑孝一郎, 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
気管・気管支形成手術の現況 2．気管・気管支形成原発性肺癌における気管・気管支形成手術の臨床的検討,
胸部外科, Vol.61, No.11, 951-956, 2008年.

(要約): In our department, there were 482 thoracic surgeries for primary lung cancer between 1994 and 2007. We clinically reviewed cases that underwent tracheoplasty or bronchoplasty (n = 22, 4.6%). The patients consisted of 21 males and 1 female (66.5 +/- 12.0 years-old). All patients were smokers. The tissue forms were 19 squamous cell carcinomas, 2 adenocarcinomas, 1 large cell carcinoma, 1 adenoid cystic carcinoma and 1 carcinoid, including 2 multiple carcinomas. Sleeve resections involved the trachea in 1, upper lobes in 13, lower lobes in 3, upper-middle lobes in 2 and intermediate bronchus in 1. Wedge resections were performed in the upper lobes in 2. Fourteen reconstructions were performed. We ordinarily sutured the trachea and bronchus in any case, using a single outside knot. There was no leakage at the anastomosis. There were 2 hospital deaths. There were 4 cancer deaths, including 2 local recurrences. There were 4 patients demonstrating stenosis post operatively. There were 3 stenoses among 4 preoperative radiation therapies. We considered that radiation therapy disturbed the repair of the anastomosis. There were 8 pneumonia patients who developed post operatively. There were 2 operative hospital deaths among 3 angio-bronchoplasties without coverage. Recently, we have routinely covered the anastomosis at the reconstruction site and have not experienced any major complications.
(キーワード): Aged / Bronchi / Female / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Prognosis / Radiotherapy, Adjuvant / Reconstructive Surgical Procedures / Thoracic Surgical Procedures / Trachea
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18939431; ● Search Scopus @ Elsevier (PMID): 18939431

(PubMed: 18939431) Yukiko Hirose, Kazuya Kondo, Hiromitsu Takizawa, Taeko Nagao, Yasushi Nakagawa, Haruhiko Fujino, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Aberrant methylation of tumour-related genes in thymic epithelial tumours.,
Lung Cancer, Vol.64, No.2, 155-159, 2008.

(要約): BACKGROUND: Thymoma is an uncommon neoplasm derived from epithelial cells of the thymus. Few studies have addressed the genetic alterations that occur in the tumourigenesis of thymoma. METHODS: We examined aberrant DNA methylation of DAP-K, p-16, MGMT and HPP1 genes in 26 thymomas and 6 thymic carcinoma to clarify the association between aberrant DNA methylation and clinicopathological features. RESULTS: Fifteen (47%) of 32 thymic epithelial tumours showed aberrant methylation. Aberrant methylation was more frequent in thymic carcinoma (86%) than in thymoma (29%). Moreover, the frequency of tumours with methylation of multiple genes in thymic carcinoma was higher than in thymoma (60% vs 20%). In thymoma, the frequency of tumour methylation, including the type A tumour component (28%), was lower than that of tumours with type B tumour component (42%). MGMT methylation was detected in 23% of thymoma and in 83% of thymic carcinoma. The frequency of methylation of the MGMT gene in both tumours was high compared with the other 3 genes. CONCLUSIONS: Aberrant DNA methylation was more frequent in thymic carcinoma than in thymoma, and the frequency of DNA methylation in thymic epithelial tumours is roughly parallel to their malignant behaviour.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2008.07.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18778870; ● Search Scopus @ Elsevier (PMID): 18778870; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2008.07.015

(DOI: 10.1016/j.lungcan.2008.07.015, PubMed: 18778870) Toshiyuki Hirose, Junko Honda, Yoshimi Bando, Mitsunori Sasa, Yukiko Hirose, Taeko Nagao and Akira Tangoku :
A case of matrix-producing carcinoma of the breast.,
World Journal of Surgical Oncology, Vol.6, 60, 2008.

(要約): BACKGROUND: Matrix-producing carcinoma (MPC) of the breast is one variant type of metaplastic carcinoma. The cellular origin of MPC remains unclear. It has been suggested the tumor cells in MPC have the combined characteristics of both epithelial cells and mesenchymal cells. Several reports suggested that the tumor cells in MPC might originate from the myoepithelial cells, but others suggested the origin was basal-like cells. CASE PRESENTATION: The patient was a 42-year-old Japanese female. A tumor of about 2 cm in diameter was noted in the right breast. CT revealed the circumference of the tumor to have a ring-like structure, and fine needle aspiration cytology indicated suspicion for malignancy. Breast-conserving surgery was performed. Histopathological studies showed carcinoma cells, having cuboidal to oval-shaped nucleus, were proliferating in cord-like and sheet-like structures in the periphery. In the central areas of the tumor, myxoedematous area was observed with cartilaginous matrix and necrosis. The diagnosis was a matrix-producing carcinoma. Immunohistochemical findings showed the tumor cells had the characteristics of both epithelial cells and mesenchymal cells, while being negative for estrogen receptor, progesterone receptor, Her2, myoepithelial cell markers and basal cell markers. CONCLUSION: The findings for our present patient and many of the other MPC patients reported in the published literature indicate that this breast cancer has the properties of both epithelial cells and mesenchymal cells. In addition, there is a possibility that matrix-producing tumor cells of our present patient may have a feature of undifferentiated cells.
(キーワード): Adult / Breast Neoplasms / Diagnosis, Differential / Epithelial Cells / 細胞外マトリックス (extracellular matrix) / Female / Humans / Receptor, erbB-2 / Receptors, Progesterone
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1477-7819-6-60
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18559079; ● Summary page in Scopus @ Elsevier: 2-s2.0-46649096056

(DOI: 10.1186/1477-7819-6-60, PubMed: 18559079, Elsevier: Scopus) 山井礼道, 吉田卓弘, 清家純一, 本田順子, 三好孝典, 武知浩和, 湯浅康弘, 梅本淳, 丹黒章, 島田光生 :
肝細胞癌孤立性大動脈周囲リンパ節転移の1切除例,
日本消化器外科学会雑誌, Vol.41, No.4, 412-417, 2008年.

(要約): 肝細胞癌の孤立性大動脈周囲リンパ節転移に対し,切除を行い良好な経過を得た症例を経験したので報告する.症例は60歳代の男性で,C型肝炎を経過観察中の2005年に腹部超音波検査で肝内腫瘤を指摘され当院紹介となった.CTで肝内に4cmと4.5cmの肝細胞癌を2個認め,大動脈周囲に2.8cmの孤立性腫瘤を認めた.大動脈周囲の孤立性腫瘤はリンパ節転移を疑ったが,鑑別診断に難渋したため,肝内病変の治療を先行し,経皮的局所療法を施行した.2か月の経過観察中に大動脈周囲の腫瘤は著明に増大傾向を示した.リンパ節転移としても孤立性であり,また,下大静脈と接することより,今後増大すれば予後因子と成りうると判断し,切除を行った.術後経過は良好で,術前2,685ng/mlと高値を示したAFPは3か月後には3ng/mlと著明に低下した.現在2年を経過するがAFPの上昇,再発は認めていない.肝細胞癌大動脈周囲孤立性リンパ節転移の報告はまれであり報告する.
(キーワード): solitary lymph node metastasis / hepatocellular carcinoma / paraaortic lymph node metastasis
(出版サイトへのリンク): ● Publication site (DOI): 10.5833/jjgs.41.412
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679895798016; ● Summary page in Scopus @ Elsevier: 2-s2.0-42149157678

(DOI: 10.5833/jjgs.41.412, CiNii: 1390282679895798016, Elsevier: Scopus) 清家純一, 松岡永, 湯浅康弘, 山井礼道, 吉田卓弘, 本田純子, 三好孝典, 丹黒章 :
Docetaxel/5‐FU/CDDP療法およびS‐1/Docetaxel療法による術前化学療法にて病理学的CRが得られた進行食道癌の1例,
癌と化学療法, Vol.35, No.4, 633-636, 2008年.

(要約): A 64-year-old woman with advanced esophageal cancer underwent chemotherapy with docetaxel/5-FU/CDDP (DFP). Adverse reactions were severe nausea and general fatigue, so the patient decided to discontinue DFP therapy. The treatment was changed to S-1/docetaxel. Adverse reactions were not so severe, so she could receive 1 course of the medication completely. After the treatment, the primary lesion showed a partial response, so we performed surgery. In the resected specimen, no malignant cell could be seen microscopically. Though the advanced esophageal cancer was regarded as a systemic disease, the appropriate combination of chemotherapy and surgery proved effective.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Cisplatin / Drug Combinations / Esophageal Neoplasms / Female / Fluorouracil / Gastroscopy / Humans / Middle Aged / Neoadjuvant Therapy / Oxonic Acid / Taxoids / Tegafur / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18408433; ● Search Scopus @ Elsevier (PMID): 18408433

(PubMed: 18408433) 吉田光輝, 先山正二, 監﨑孝一郎, 鳥羽博明, 近藤和也, 丹黒章 :
手術の工夫両側転移性肺腫瘍に対するclamshell incisionによるアプローチ,
胸部外科, Vol.61, No.3, 206-209, 2008年.

(要約): In recent years thoracotomy by "clamshell incision" has frequently been chosen for heart-lung transplantation, bilateral lung tumors and mediastinal tumor merging into lung tumor because this approach provides very good visibility to access the whole bilateral lung including the lower lobe and mediastinal organs. In our hospital, 4 patients underwent bilateral thoracotomy by clamshell incision for pulmonary metastasectomy between 2001 and 2005. All cases had bilateral pulmonary metastases, and multiple wedge resection was performed. All lesions that were planned for resection on preoperative computed tomography (CT) could be resected. Regarding the surgical approach to bilateral pulmonary metastases that did not need lobectomy, clamshell incision is one of the useful approaches that can allow wedge resection anywhere in the whole lung. In cases that are expected multiple procedures, bilateral thoracotomy by clamshell incision is recommended because it allows another route for thoracotomy at reoperation.
(キーワード): Adult / Aged / Female / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Sternum / Thoracotomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18323186; ● Search Scopus @ Elsevier (PMID): 18323186

(PubMed: 18323186) Junko Honda, Mitsunori Sasa, Takuya Moriya, Yoshimi Bando, Toshiyuki Hirose, Masako Takahashi, Taeko Nagao and Akira Tangoku :
Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results.,
The Journal of Medical Investigation : JMI, Vol.55, No.1-2, 54-60, 2008.

(要約): Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i. e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.
(キーワード): Adult / Aged / Antimetabolites, Antineoplastic / Breast Neoplasms / Deoxycytidine / Dihydrouracil Dehydrogenase (NADP) / Female / Fluorouracil / Forecasting / Humans / Immunohistochemistry / Middle Aged / Retrospective Studies / Therapeutic Equivalency / Thymidine Phosphorylase / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 110839
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.55.54
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18319546; ● Search Scopus @ Elsevier (PMID): 18319546; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.54

(徳島大学機関リポジトリ: 110839, DOI: 10.2152/jmi.55.54, PubMed: 18319546) 鳥羽博明, 近藤和也, 吉田光輝, 監﨑孝一郎, 三好孝典, 先山正二, 丹黒章 :
縦隔悪性リンパ腫の臨床的検討,
胸部外科, Vol.61, No.2, 97-101, 2008年.

(要約): Sixteen cases of mediastinal lymphoma in our hospital were reviewed clinically. There were 7 men and 9 women, whose mean age is 35 years old. The histological types were non-Hodgkins' disease in 12 (B-cell type in 6 and T-cell type in 6), Hodgkins' disease in 2, mucosa-associated lymphoid tissue (MALT) lymphoma in 2. All cases except 1 in which percutaneous needle biopsy was performed were diagnosed histologically. Even small specimens by percutaneous needle biopsy can be helpful in diagnosing histological type and subtype with immunohistlogy, recommending percutaneous needle biopsy as an mitial step for diagnosis. When histological diagnosis can not be made by needle biopsy, open biopsy should be done.
(キーワード): Adolescent / Adult / Aged / Child / Combined Modality Therapy / Diagnosis, Differential / Female / Hodgkin Disease / Humans / Lymphoma, B-Cell / Lymphoma, B-Cell, Marginal Zone / Lymphoma, T-Cell / Male / Mediastinal Neoplasms / Middle Aged / Salvage Therapy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18268943; ● Search Scopus @ Elsevier (PMID): 18268943

(PubMed: 18268943) Hiromitsu Takizawa, Kazuya Kondo, Hisashi Matsuoka, Koh Uyama, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama, Akira Tangoku, Kazumasa Miura, Kiyoshi Yoshizawa and Junji Morita :
Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer,
The Journal of Medical Investigation : JMI, Vol.55, No.1,2, 37-43, 2008.

(要約): Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58: sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 +/- 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 +/- 7.0 (p < 0.001). Postoperatively N2 disease was detected in 8 patients (13.8%) in the dissection group and 7 (11.5%) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% in the dissection group and 76.2% in the sampling group (p = 0.60). Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma, Small Cell / Female / Follow-Up Studies / Humans / Lung Neoplasms / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Male / Mediastinum / Middle Aged / Neoplasm Staging / Pneumonectomy / Prognosis / Retrospective Studies / Survival Rate
(徳島大学機関リポジトリ): ● Metadata: 110836
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.55.37
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18319543; ● Search Scopus @ Elsevier (PMID): 18319543; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.37

(徳島大学機関リポジトリ: 110836, DOI: 10.2152/jmi.55.37, PubMed: 18319543) Aoi Matsuoka, Masako Minato, Masafumi Harada, Hitoshi Kubo, Yoshikatsu Bandou, Akira Tangoku, Kiichirou Nakano and Hiromu Nishitani :
Comparison of 3.0-and 1.5-tesla diffusion-weighted imaging in the visibility of breast cancer.,
Radiation Medicine, Vol.26, No.1, 15-20, 2008.

(要約): PURPOSE: The aim of this study was to compare diffusion-weighted imaging (DWI) at 3.0 T and 1.5 T by evaluating the apparent diffusion coefficient (ADC) value and visibility of breast cancer in the same patients. MATERIALS AND METHODS: A total of 13 patients (16 lesions) with breast cancer underwent DWI at 3.0 T and 1.5 T. Tumors were classified into two groups based on the lesion size. The ADC values were measured, and visibility of the tumors was scored blindly. RESULTS: No significant difference was found for ADC values between 3.0 T and 1.5 T in either group (P > 0.05). All of the large lesions were visible clearly at both magnetic field strengths, and image scores were not different (P > 0.05). In contrast, small lesions were more clearly visible and had better image scores at 3.0 T than at 1.5 T (P < 0.001). CONCLUSION: Small cancers were more clearly visible on DWI at 3.0 T than 1.5 T.
(キーワード): Breast Neoplasms / Diffusion Magnetic Resonance Imaging / Female / Humans / Image Interpretation, Computer-Assisted
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11604-007-0187-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18236129; ● Search Scopus @ Elsevier (PMID): 18236129; ● Search Scopus @ Elsevier (DOI): 10.1007/s11604-007-0187-6

(DOI: 10.1007/s11604-007-0187-6, PubMed: 18236129) Kazuya Kondo, Takanori Miyoshi, Haruhiko Fujino, Hiromitsu Takizawa, Satoshi Imai, Naoki Kobayashi, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Photodynamic therapy using a second generation photosensitizer, Talaporfin,
Photodiagnosis and Photodynamic Therapy, Vol.4, No.4, 269-274, 2007.

(要約): Background: Photodynamic therapy (PDT) using Talaporfin is an attractive treatment for centraltype early lung cancer. It was noted that some patients had altered levels of arterial oxygen saturation as indicated by pulse oximeter (SpO2) and arterial oxygen saturation levels in blood gas analysis (SaO2) during PDT. The present experiments were designed to provide an explanation for these findings. Methods: The influence of Talaporfin on SpO2 using in vitro and in vivo experiments, and clinically, was examined. Results: Our in vitro and in vivo experiments showed a linear relationship between Talaporfin concentration in the plasma and the SpO2 level (R = 0.9957 and 0.9837). The apparent SpO2 level decreased according to the increase of Talaporfin concentration in the plasma. In two patients with PDT, SpO2 levels at 4 6 h and 24 h after Talaporfin administration were 93% and 97%, respectively. Conclusions: Talaporfin raised blood absorbance at 660nm with a pulse oximeter. It appeared that the presence of the drug falsely decreased the level of SpO2 since SpO2 did not actually change.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.pdpdt.2007.06.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.pdpdt.2007.06.001

(DOI: 10.1016/j.pdpdt.2007.06.001) 清家純一, 吉田卓弘, 本田純子, 三好孝典, 梅本淳, 丹黒章 :
Docetaxel/5‐FU/CDDP併用化学放射線療法後UFT単独外来投与が有効であった高齢者進行頸部食道癌の1例,
癌と化学療法, Vol.34, No.8, 1271-1274, 2007年.

(要約): An 80-year-old woman with advanced cervical esophageal cancer underwent chemoradiotherapy with docetaxel/5-FU/CDDP (DFP). The tumor reduced in size after the treatment,but severe pancytopenia and scar stenosis of cervical esophagus appeared. In consideration of her age,the treatment was changed to the administration of UFT alone on an outpatient basis. Ten months after the medication, a follow-up CT scan showed multiple lung metastases and mediastinal lymph node metastases. The patient was treated with DFP therapy again, and all tumors reduced in size, but severe general fatigue and pancytopenia appeared during this therapy. Given the difficulty of continuing this therapy, the treatment was changed to UFT alone on an outpatient basis. The followup CT scan showed a reduction in the size of all tumors even 8 months after discharge. UFT alone appears to be safe and effective as maintenance therapy after DFP therapy, especially for elderly patients.
(キーワード): Aged, 80 and over / Ambulatory Care / Antineoplastic Combined Chemotherapy Protocols / Cisplatin / Combined Modality Therapy / Drug Administration Schedule / Drug Combinations / Esophageal Neoplasms / Female / Fluorouracil / Humans / Lung Neoplasms / Lymph Nodes / Lymphatic Metastasis / Quality of Health Care / Taxoids / Tegafur / Uracil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17687211; ● Search Scopus @ Elsevier (PMID): 17687211

(PubMed: 17687211) Yukiko Hirose, Mitsunori Sasa, Yoshimi Bando, Toshiyuki Hirose, Tadaoki Morimoto, Yasushi Kurokawa, Taeko Nagao and Akira Tangoku :
Bilateral male breast cancer with male potential hypogonadism.,
World Journal of Surgical Oncology, Vol.5, 60, 2007.

(要約): BACKGROUND: Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases. CASE PRESENTATION: The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potential hypogonadism, and these hormonal abnormalities seemed to be present since childhood or the fetal period. The bilateral breast cancer developed in this man at a comparatively young age, and histopathological studies of multiple sections showed that there was almost no normal epithelial cell in the ducts, while the ducts were almost completely filled with breast cancer cells. CONCLUSION: It is thought that male breast cancer is caused by an imbalance between estrogen and testosterone. We cannot rule out the possibility that the breast cancer developed due to the effect of the slight elevation of estrogen over a long period of time, but the actual causative factors in this patient were unable to be definitively identified. In the future, we hope to further elucidate the causes of male breast cancer.
(キーワード): Biopsy, Needle / Breast Neoplasms, Male / Follow-Up Studies / Humans / Hypogonadism / Hypospadias / Immunohistochemistry / Male / Mammography / Mastectomy / Middle Aged / Treatment Outcome / Ultrasonography, Doppler
(出版サイトへのリンク): ● Publication site (DOI): 10.1186/1477-7819-5-60
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17543123; ● Summary page in Scopus @ Elsevier: 2-s2.0-34250766722

(DOI: 10.1186/1477-7819-5-60, PubMed: 17543123, Elsevier: Scopus) Masatsugu Takehisa, Mitsunori Sasa, Yoshimi Bando, Toshiyuki Hirose, Tadaoki Morimoto, Taeko Nagao and Akira Tangoku :
Chromosomal aneusomy (chr 1, 11, 17) detected by fluorescence in situ hybridization may be a prognostic factor in breast cancer.,
Anticancer Research, Vol.27, No.2, 1073-1078, 2007.

(要約): The relationship between clinicopathological findings and the long-term prognosis was investigated in 42 breast cancer patients in whom aneusomy was detected for chromosomes 1, 11 and 17. The frequencies of aneusomy of those chromosomes were 78.6%, 47.5% and 52.5%, respectively, and more than 90% of anomalies consisted of polysomy. The relationship between aneusomy and the clinicopathological findings showed a statistical correlation with a high histological grade in the case of polysomy of chromosome 17 compared with disomy, indicating a tendency for a high incidence of lymph node metastasis. Analysis of the survival data revealed that the prognosis was poor when there was polysomy of chromosomes 1 or 11. These results indicate the possibility that aneusomy of chromosomes 1, 11 and 17 can serve as prognostic factors of poor outcome in breast cancer patients.
(キーワード): Biopsy, Fine-Needle / Breast Neoplasms / Chromosome Aberrations / Chromosomes, Human, Pair 1 / Chromosomes, Human, Pair 11 / Chromosomes, Human, Pair 17 / Humans / In Situ Hybridization, Fluorescence / Lymphatic Metastasis / Neoplasm Staging / Prognosis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17465246; ● Search Scopus @ Elsevier (PMID): 17465246

(PubMed: 17465246) Akira Tangoku, Junichi Seike, Kiichiro Nakano, Taeko Nagao, Junko Honda, Takahiro Yoshida, Hiromichi Yamai, Hisashi Matsuoka, Kou Uyama, Masakazu Goto, Takanori Miyoshi and Tadaoki Morimoto :
Current status of sentinel lymph node navigation surgery in breast and gastrointestinal tract.,
The Journal of Medical Investigation : JMI, Vol.54, No.1-2, 1-18, 2007.

(要約): Sentinel lymph node biopsy (SLNB) has been developed as a new diagnostic and therapeutic modality in melanoma and breast cancer surgery. The purpose of the SLNB include preventing the operative morbidity and improving the pathologic stage by focusing on fewer lymph nodes using immunocytochemic and molecular technology has almost achieved in breast cancer surgery. The prognostic meaning of immunocytochemically detected micrometastases is also evaluating in the SLN and bone marrow aspirates of women with early-stage breast cancer. SLNB using available techniques have suggested that the lymphatic drainage of the gastrointestinal tract is much more complicated than other sites, skip metastasis being rather frequent because of an aberrant lymphatic drainage outside of the basin exist.At the moment, the available data does not justify reduced extent of lymphadenectomy, but provides strong evidence for an improvement in tumor staging on the basis of SLNB. Two large scale prospective multi-center trials concerning feasibility of gamma-probe and dye detection for gastric cancer are ongoing in Japan.Recent studies have shown favorable results for identification of SLN in esophageal cancer. CT lymphography with endoscopic mucosal injection of iopamidol was applicable for SLN navigation of superficial esophageal cancer. The aim of surgical treatment is complete resection of the tumor-infiltrated organ including the regional lymph nodes. Accurate detection of SLN can achieve a selection of a more sophisticated tailor made approach. The patient can make a individualized choice from a broader spectrum of therapeutic options including endoscopic, laparoscopic or laparoscopy-assisted surgery, modified radical surgery, and typical radical surgery with lymph node dissection. Ultrastaging by detecting micrometastasis at the molecular level and the choice of an adequate treatment improve the postoperative quality of life and survival. However these issues require further investigation.
(キーワード): Breast Neoplasms / Colorectal Neoplasms / Esophageal Neoplasms / False Negative Reactions / Female / Gastrointestinal Neoplasms / Humans / Lymphography / Sentinel Lymph Node Biopsy / Stomach Neoplasms / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 111489
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.54.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17380009; ● Search Scopus @ Elsevier (PMID): 17380009; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.1

(徳島大学機関リポジトリ: 111489, DOI: 10.2152/jmi.54.1, PubMed: 17380009) Mitsuteru Yoshida, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Two cases of bronchogenic cyst with severe adhesion to the trachea,
The Journal of Medical Investigation : JMI, Vol.54, No.1-2, 187-190, 2007.

(要約): We experienced two bronchogenic cysts with severe adhesion to the trachea. Both cysts were located on the right side of the trachea. The surgical procedure was changed to thoracotomy from thoracoscopic surgery due to strong adhesion to the trachea. In case 1, sharp separation of the cystic wall from the trachea led to tracheal wall damage. In case 2, the cystic wall except a portion which was adhered to the trachea was resected. The inner side of the residual cystic wall underwent dull curettage to remove the epithelial component. There were no postoperative complications in either case.
(キーワード): Adult / Bronchogenic Cyst / Female / Humans / Thoracotomy / Tissue Adhesions / Tracheal Diseases
(徳島大学機関リポジトリ): ● Metadata: 111512
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.54.187
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17380032; ● Search Scopus @ Elsevier (PMID): 17380032; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.187

(徳島大学機関リポジトリ: 111512, DOI: 10.2152/jmi.54.187, PubMed: 17380032) Takanori Miyoshi, Kazuya Kondo, Hiroaki Toba, Mitsuteru Yoshida, Haruhiko Fujino, Koichiro Kenzaki, Shoji Sakiyama, Masatsugu Takehisa and Akira Tangoku :
Predictive Value of Thymidylate Synthase and Dihydropyrimidine Dehydrogenase Expression in Tumor Tissue, Regarding the Efficacy of Postoperatively Administered UFT(Tegafur+Uracil) in Patients with Non-small Cell Lung Cancer,
Anticancer Research, Vol.27, No.4C, 2641-2648, 2007.

(要約): UFT (tegafur + uracil) has been reported to be effective as an adjuvant in postoperative chemotherapy for non-small cell lung cancer (NSCLC) in a randomized prospective study. Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression were investigated in resected tumors and the relationship between their expression and clinical factors in NSCLC patients was examined. Fifty-four NSCLC patients had undergone complete surgical resection and lymph node dissection, and had been administered UFT post-surgery. The TS and DPD expression in the tumor tissues was evaluated by immunohistochemical staining. The relationship between TS and/or DPD expression and clinicopathological factors was examined. There were 38 TS-negative and 16 TS-positive cases, and 22 DPD-negative and 32 DPD-positive cases. There was no significant difference between the patients with TS or DPD and those without TS or DPD in age, gender, histological type or p-stage. The 5-year survival rates of patients positive and negative for TS were 50.0 and 89.5%, while 10-year survival rates were 23.3 and 79.7%, respectively (p<0.001). The 5-year survival rates of TS-positive and TS-negative patients in p-stage I were 54.6 and 95.5%, while 10-year survival rates were 22.7 and 95.5%, respectively (p<0.001). There was no significant difference between DPD-positive and DPD-negative patients in prognosis. The oral administration of UFT after surgery might improve the survival of NSCLC patients when TS levels in tumor tissues are low. Immunohistochemical evaluation of TS and DPD expression may be useful for predicting the efficacy of UFT after complete resection in NSCLC.
(キーワード): Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Non-Small-Cell Lung / Dihydrouracil Dehydrogenase (NADP) / Female / Humans / Immunohistochemistry / Lung Neoplasms / Lymph Node Excision / Male / Middle Aged / Neoplasm Staging / Tegafur / Thymidylate Synthase / Uracil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17695427; ● Search Scopus @ Elsevier (PMID): 17695427

(PubMed: 17695427) Taeko Nagao, Yoshimi Bando, Mitsunori Sasa, Tadaoki Morimoto, Nobuya Sano, Toshiyuki Hirose and Akira Tangoku :
False-positive in fine-needle aspiration cytology of breast disease can be reduced with p63 immunostaining- A preliminary report,
Anticancer Research, Vol.26, No.6B, 4373-4378, 2006.

(要約): Myoepithelial cells of the mammary gland are considered to be a key to distinguishing benign from malignant disease in fine-needle aspiration (FNA) cytology. However, identification of these cells with Papanicolaou staining is not easy. The identification of myoepithelial cells was investigated using p63 antibodies to carry out immunostaining of FNA specimens that had been used at the time of Papanicolaou staining for 37 patients who yielded false-positives in FNA. Positively-stained cells were observed in overlying cell clusters or the background in 67.6% of the patients. There is a possibility that over-diagnosis could have been avoided by performing p63 staining for these patients. The controls consisted of stamp samples of fresh specimens obtained from 23 patients at the time of surgery for invasive carcinoma and the results of p63 immunostaining did not reveal any positive staining of tumor cells. Accordingly, these results indicate that there is a strong likelihood that there is no invasive carcinoma when many p63-positive cells are observed in the tumor cell population or the background and that p63 immunostaining has the potential to aid in reducing false-positives at the time of FNA diagnosis of breast disease.
(キーワード): Biopsy, Needle / Breast Neoplasms / DNA-Binding Proteins / False Positive Reactions / Female / Humans / Middle Aged / Trans-Activators / Transcription Factors / Tumor Suppressor Proteins
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17201157; ● Summary page in Scopus @ Elsevier: 2-s2.0-33845916979

(PubMed: 17201157, Elsevier: Scopus) Junichi Seike, Takahiro Yoshida, Junko Honda, Takanori Miyoshi, Atsushi Umemoto and Akira Tangoku :
A case of early relapsed multiple lung metastases after esophagectomy successfully treated with S-1/cisplatin therapy after docetaxel/5-fluorouracil/cisplatin therapy.,
The Journal of Medical Investigation : JMI, Vol.53, No.3-4, 321-324, 2006.

(要約): A 55-year-old-male patient underwent subtotal esophagectomy for esophageal cancer (pT1b, N0, M0, stage II) in April 2005. The patient received postoperative chemotherapy (docetaxel 40 mg/body, 5-fluorouracil 750 mg/body, cisplatin 10mg/body: administered every 4 weeks) for 3 months. Six months postoperatively, routine follow up CT demonstrated multiple metastatic tumors in the bilateral lungs. Under the diagnosis of multiple lung metastases, the patient was hospitalized and received intensive chemotherapy with docetaxel 40 mg/week (day 1), 5-fluorouracil 500 mg/day (days 1-5), cisplatin 10 mg/day (days 1-5). After two weeks administration, the patient eagerly hoped for outpatient treatment. The treatment was changed to outpatient chemotherapy with S-1 100 mg/day (continuous administration for 3 weeks followed by rest for 1 week) and cisplatin 20 mg/every week. The treatment enabled the patient to keep working. Follow up CT showed disappearance of all tumors two months after TS-1/cisplatin chemotherapy. There were no obvious signs of recurrence 5 months after chemotherapy. The S-1/cisplatin therapy in the outpatient was thought to be one of the effective treatments in maintaining quality of life for the patient.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Cisplatin / Combined Modality Therapy / Drug Combinations / Esophageal Neoplasms / Esophagectomy / Fluorouracil / Humans / Lung Neoplasms / Male / Middle Aged / Neoplasm Metastasis / Oxonic Acid / Recurrence / Taxoids / Tegafur
(徳島大学機関リポジトリ): ● Metadata: 110830
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.53.321
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16953072; ● Search Scopus @ Elsevier (PMID): 16953072; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.53.321

(徳島大学機関リポジトリ: 110830, DOI: 10.2152/jmi.53.321, PubMed: 16953072) Kazuya Kondo, Yuji Takahashi, Yukiko Hirose, Taeko Nagao, Masaru Tsuyuguchi, Masato Hashimoto, Atsushi Ochiai, Yasumasa Monden and Akira Tangoku :
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.,
Lung Cancer, Vol.53, No.3, 295-302, 2006.

(要約): STUDY OBJECTIVES: It is known that chromium is one of the important inhaled carcinogens that cause lung cancer. Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). However, the epigenetic effects of chromium are not understood. MATERIALS AND METHODS: We investigated the methylation of the p16 gene using a methylation-specific PCR method in 30 chromate lung cancers and 38 non-chromate lung cancers, and the expression of the p16 protein using immunohistochemistry in 25 chromate lung cancers. RESULTS: Ten (33%) chromate lung cancers showed methylation of the p16 promoter region. On the other hand, 10 (26%) of the non-chromate lung cancers also showed it. The frequency of p16 methylation in non-chromate lung cancer was 0%, 33% and 30% for low (< or =600), moderate (<600, >1000) and high (> or =1000) Brinkman indexes, respectively. However, the frequency of p16 methylation in chromate lung cancer was constant, irrespective of the Brinkman index. In chromate lung cancer, patients with chromate exposure of less than 15 years never had p16 methylation, while 40% (> or =25 years) or 43% (> or =15, <25 years) of patients with chromate exposure of more than 15 years did. In chromate lung cancer, chromate exposure, not smoking, mainly influenced the p16 methylation. Most of the chromate lung cancers with p16 methylation (85.7%) showed repression of the p16 protein. CONCLUSIONS: We speculate that not only genetic but also epigenetic alterations are involved in the carcinogenesis due to chromium.
(キーワード): Adult / Aged / Chromates / Chromium / Cyclin-Dependent Kinase Inhibitor p16 / DNA (DNA) / DNA Methylation / Epigenesis, Genetic / Gene Expression Regulation, Neoplastic / Humans / Lung Neoplasms / Male / Middle Aged / Occupational Exposure / Sulfites
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2006.05.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16828922; ● Search Scopus @ Elsevier (PMID): 16828922; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2006.05.022

(DOI: 10.1016/j.lungcan.2006.05.022, PubMed: 16828922) Kansei Komaki, Nobuya Sano and Akira Tangoku :
Problems in histological grading of malignancy and its clinical significance in patients with operable breast cancer.,
Breast Cancer, Vol.13, No.3, 249-253, 2006.

(要約): Although the histological grading of malignancy in patients with operable breast cancer, typically consisting of three factors: tubular formation, mitotic counts, and nuclear atypia, plays an important role in identifying patients at high risk of recurrence, the most effective combination of factors is still not completely clear. In assessing prognosis, the problems of clinical application of the grade of malignancy are not only related to the assemblage of the factors employed, but also to the heterogeneity within the tumor and interobserver variations. In a review of the correlation between the histological grading system for malignancy in operable breast cancer patients and the recurrence rate, only the grade of nuclear atypia statistically correlated with the rate of recurrence. Furthermore, a grading system consisting of mitotic counts and nuclear atypia was more significantly correlated to the risk of recurrence than was the system based on the three factors described above. Concerning the heterogeneity of histologic features within the primary tumor, a system based on the grade of mitotic counts or nuclear atypia showed a high degree of heterogeneity, but a system based on the grade of tubular formation showed low heterogeneity and bimodal distribution.
(キーワード): Breast Neoplasms / Humans / Neoplasm Staging / Prognosis
(出版サイトへのリンク): ● Publication site (DOI): 10.2325/jbcs.13.249
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16929117; ● Summary page in Scopus @ Elsevier: 2-s2.0-39049180068

(DOI: 10.2325/jbcs.13.249, PubMed: 16929117, Elsevier: Scopus) 池田雅彦, 園尾博司, 田中克浩, 紅林淳一, 森本忠興, 丹黒章, 駒木幹正, 片岡健, 石黒清介, 吉澤潔 :
進行・再発乳癌に対するBi‐weekly Docetaxelと5′‐DFURの併用化学療法における安全性と効果の検討—第I相試験—,
癌と化学療法, Vol.33, No.6, 767-771, 2006年.

(要約): BACKGROUND: A clinical trial of Docetaxel was performed by tri-weekly administration in patients with advanced or recurrent breast cancer. However, careful observation is necessary for outpatients because serious neutropenia often occurs during the therapy. A bi-weekly schedule is recommended since weekly administration requires more visits to the hospital. Docetaxel is proved to express synergistic efficacy in combination with 5'-DFUR by induced dThdPase in vivo. But there are no clinical trials to evaluate efficacy of bi-weekly Docetaxel and 5'-DFUR combination therapy. PURPOSE: To evaluate safety, the recommended dose of Docetaxel and the efficacy of biweekly Docetaxel and 5'-DFUR combination therapy. PATIENTS AND METHODS: Patients with advanced or recurrent breast cancer within 1 regimen of prior chemotherapy and without prior use of both Docetaxel and 5'-DFUR were enrolled. 5'-DFUR was orally administered by 600 mg/day. Docetaxel was intravenously given for at least 2 cycles (8 weeks) by 30 mg/m(2) for level 1, 40 mg/m(2) for level 2 and 50 mg/m(2) for level 3. At each level with 3 cases enrolled,the maximum tolerated dose (MTD) level was defined as that in which 2 or 3 cases showed dose limiting toxicity (DLT). The recommended dose was defined as the dose before MTD level. Therapeutic safety was evaluated by analyses of adverse events with the recommended dose. RESULTS: MTD was in level 3 and the recommended dose of Docetaxel was 40 mg/m(2) of level 2. No DLT was observed in level 2, and this combination therapy seemed safe and feasible for outpatients. In addition, all 6 cases for whom therapeutic efficacy was evaluated expressed a clinical response.
(キーワード): Administration, Oral / Aged / Ambulatory Care / Antineoplastic Combined Chemotherapy Protocols / Bone Neoplasms / Breast Neoplasms / Dose-Response Relationship, Drug / Drug Administration Schedule / Female / Floxuridine / Humans / Lung Neoplasms / Maximum Tolerated Dose / Middle Aged / Neoplasm Recurrence, Local / Taxoids
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16770094; ● Search Scopus @ Elsevier (PMID): 16770094

(PubMed: 16770094) 監﨑孝一郎, 先山正二, 近藤和也, 吉田光輝, 長尾妙子, 中川靖士, 滝沢宏光, 三好孝典, 丹黒章 :
胸部外科の指針原発性肺癌における手術死亡および在院死亡,
胸部外科, Vol.59, No.5, 347-52, 2006年.

(要約): In our department, there were 313 thoracic surgeries for primary lung cancer from January 1994 to December 2003. We clinically reviewed for the operative and hospital death (n=18, 5.8%). The patients were 16 males and 2 females (70.6 +/- 5.6 years old). The surgical procedures were 4 pneumonectomies, 13 lobectomies (3 bronchoplasties) and 1 partial resection. The mean interval until postoperative death was 122.5 +/- 156.1 days. There were 5 direct operative deaths within 30 days (1.6%). There were 4 cancer deaths, 2 hemoptyses, 2 operative bleeding, 2 thromboses, 2 cerebral hemorrhages, 1 pyothorax, 1 pneumonia, 1 respiratory failure, 1 multiple organ failure after chemotherapy and 2 unexplained deaths. The patients with pneumonectomy or aged significantly had high mortality. For postoperative complications such as hemoptysis or bleeding, perioperative management that takes these issues into consideration is needed. Furthermore, we must carefully review the preoperative evaluation and combined treatment, because there were many cancer deaths among cases showing early recurrence and metastasis.
(キーワード): Adenocarcinoma / Aged / Aged, 80 and over / Carcinoma, Squamous Cell / Female / Hospital Mortality / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16715882; ● Search Scopus @ Elsevier (PMID): 16715882

(PubMed: 16715882) Koichiro Kenzaki, Shoji Sakiyama, Kazuya Kondo, Mitsuteru Yoshida, Yukikiyo Kawakami, Masatsugu Takehisa, Hiromitsu Takizawa, Takanori Miyoshi, Yoshimi Bando, Akira Tangoku and Mingyao Liu :
Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma.,
Journal of Thoracic and Cardiovascular Surgery, Vol.131, No.5, 1148-1153, 2006.

(要約): OBJECTIVE: The capability of regeneration of lung tissues in adults is limited after chronic destruction. Bone marrow-derived stem cells, retinoic acid, growth factors, and other approaches have been attempted to promote or facilitate this process. We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration. METHODS: Day 17 fetal lung tissue fragments at the pseudoglandular stage of lung development from Lewis rats were implanted into adult Lewis rat lungs. For group 1, fetal lung fragments were injected into the adult left lung parenchyma; for group 2, fetal fragments were injected with the left lung partially resected; for group 3, adult fragments were injected; and for groups 4 and 5, fetal fragments were implanted into the omentum and subcutaneous tissue, respectively. RESULTS: The grafts implanted into pulmonary parenchyma were differentiated with opening of the alveolar space after 4 weeks and were advanced further with morphologic features similar to those of neonatal lungs after 8 and 12 weeks. The implants were connected with pulmonary circulation determined by means of perfusion with India ink. These changes appeared to be further enhanced in animals with partial lung resection that might have facilitated the maturation of implanted fetal lung tissues through mechanical factors, soluble factors, or both. Fetal lung tissues did not mature when implanted into the omentum or subcutaneous tissue. Adult lung fragments did not expand after being reimplanted back into the same animal. CONCLUSIONS: Fetal lung tissue might be an option for further investigation into lung regeneration.
(キーワード): Age Factors / Animals / Female / Fetus / Lung / Lung Transplantation / Models, Animal / Pneumonectomy / Pregnancy / Rats / Rats, Inbred Lew / Regeneration
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2005.11.041
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16678603; ● Search Scopus @ Elsevier (PMID): 16678603; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2005.11.041

(DOI: 10.1016/j.jtcvs.2005.11.041, PubMed: 16678603) Takanori Miyoshi, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kenzaki, Haruhiko Fujino, Shoji Sakiyama and Akira Tangoku :
Fluoroscopy-assisted thoracoscopic resection of pulmonary nodules after computed tomography--guided bronchoscopic metallic coil marking.,
Journal of Thoracic and Cardiovascular Surgery, Vol.131, No.3, 704-710, 2006.

(要約): OBJECTIVE: To localize small and deeply situated pulmonary nodules during thoracoscopy with roentgenographic fluoroscopy, we developed a marking procedure that uses a metallic coil. METHODS: Nine patients underwent video-assisted thoracoscopic surgery for the removal of 11 pulmonary lesions. Fluoroscopy-assisted thoracoscopic surgery after computed tomography-guided bronchoscopic metallic coil marking was performed with an ultrathin bronchoscope, with simulation by means of virtual bronchoscopy. During thoracoscopy, a C-arm-shaped roentgenographic fluoroscope was used to detect the radiopaque nodules. RESULTS: The marking procedure took 15 to 60 minutes from insertion to removal of the bronchoscope. There were no complications from the marking, and all 11 nodules were easily localized by means of thoracoscopy. The metallic coil showed the nodules on the fluoroscopic monitor, which aided in nodule manipulation. Nodules were completely resected under thoracoscopic guidance, except in one case in which a minithoracotomy was performed at an early stage of the trial. The pathologic diagnosis was primary adenocarcinoma in 9 patients, pulmonary metastasis from colon cancer in 1 patient, and pulmonary lymph node in 1 patient. Two cases of bronchioloalveolar adenocarcinoma with an invasive component and a well-differentiated adenocarcinoma were converted to open thoracotomy to perform curative lobectomy. CONCLUSIONS: In this pilot study computed tomography-guided transbronchial metallic coil marking with an ultrathin bronchoscope with virtual bronchoscopic simulation might be a useful method for the fluoroscopy-assisted thoracoscopic resection of pulmonary nodules.
(キーワード): Adult / Aged / Aged, 80 and over / Bronchoscopes / Bronchoscopy / Female / Fluoroscopy / Humans / Lung Neoplasms / Male / Middle Aged / Pilot Projects / Reproducibility of Results / Thoracic Surgery, Video-Assisted / Thoracoscopy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2005.09.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16515927; ● Search Scopus @ Elsevier (PMID): 16515927; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2005.09.019

(DOI: 10.1016/j.jtcvs.2005.09.019, PubMed: 16515927) Hideto Hayashi, Akira Tangoku, Kazuyoshi Suga, Kensaku Shimizu, Katsuhiko Ueda, Shigefumi Yoshino, Toshihiro Abe, Tomomitsu Sato, Naofumi Matsunaga and Masaaki Oka :
CT lymphography-navigated sentinel lymph node biopsy in patients with superficial esophageal cancer.,
Surgery, Vol.139, No.2, 224-235, 2006.

(要約): BACKGROUND: To evaluate experimentally and clinically the feasibility of a newly developed technique of endoscopic computed tomography (CT) lymphography with endoscopic submucosal injection of iopamidol for esophageal sentinel lymph node (SLN) mapping and biopsy examination. METHODS: Nine anesthetized dogs underwent CT after endoscopic submucosal injection of 2 mL iopamidol; 1.25-mm thick CT images were obtained before and at 1, 3, 5, 7, and 10 minutes after contrast injection. Clinically, 12 patients with superficial esophageal cancer (preoperative imaging stage: cT1, cN0) underwent CT lymphography in a similar fashion at 1, 5, and 10 minutes after peritumoral injection, followed by radical esophagectomy and regional lymph node dissection under CT lymphography guidance. RESULTS: CT lymphography visualized the draining lymphatic vessels and SLNs within 5 minutes after contrast injection. All 14 SLNs in dogs (average, 1.5 nodes per animal; range, 1-2) and 28 SLNs in patients (average, 2.3 nodes per patient; range, 1-4) were found intraoperatively at the correct location under CT lymphography guidance. Lymph node metastasis could be detected with excellent sensitivity and accuracy in this small number of patients with no false-negative findings; metastasis was positive only in the preoperatively identified SLNs in 4 patients and in both SLNs and distant nodes in 1 patient, and was negative in all resected nodes in the remaining 7 patients. CONCLUSIONS: Endoscopic CT lymphography appears to allow accurate identification of direction and locations of lymph flow and SLNs, and has the potential clinical applicability for esophageal SLN mapping and biopsy examination, but will require a large study to determine its accuracy and usefulness.
(キーワード): Aged / Animals / Contrast Media / Dogs / Endoscopy / Esophageal Neoplasms / Female / Humans / Iopamidol / Lymphatic Metastasis / Lymphography / Male / Middle Aged / Sensitivity and Specificity / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.surg.2005.07.027
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16455332; ● Summary page in Scopus @ Elsevier: 2-s2.0-31644441225

(DOI: 10.1016/j.surg.2005.07.027, PubMed: 16455332, Elsevier: Scopus) Kazuyoshi Suga, Kensaku Shimizu, Yasuhiko Kawakami, Akira Tangoku, Mohammed Zaki, Naofumi Matsunaga and Masaaki Oka :
Lymphatic drainage from esophagogastric tract: feasibility of endoscopic CT lymphography for direct visualization of pathways.,
Radiology, Vol.237, No.3, 952-960, 2005.

(要約): PURPOSE: To evaluate the feasibility of an endoscopic computed tomographic (CT) lymphography technique with submucosal injection of iopamidol for direct visualization of lymphatic drainage pathways in dogs and in patients with operable esophageal cancer. MATERIALS AND METHODS: With institutional animal committee approval, a total of 2 mL of undiluted iopamidol was injected into the esophageal (n = 6) or gastric (n = 3) submucosa in nine dogs by using a flexible endoscope. Multi-detector row CT images (section thickness, 1.25 mm) were obtained before contrast material injection and during the 10 minutes after injection. The animals were euthanized so that their lymphatic anatomy could be examined. With ethical committee approval and patient informed consent, nine patients with esophageal cancer also underwent CT lymphography with peritumoral injection of 2 mL of iopamidol, followed by esophagectomy and regional lymph node dissection with CT lymphographic guidance. The histopathologic features of dissected nodes, including sentinel lymph nodes (SLNs), were examined. RESULTS: CT lymphography depicted the direct connection of lymphatic drainage vessels with enhanced and/or unenhanced nodes (ie, SLNs) as early as within 5 minutes after contrast material injection in all subjects. All 13 SLNs in dogs (1.4 nodes per animal) and 18 SLNs in patients (two nodes per patient) were found and dissected at the correct location by using CT lymphographic guidance. In patients, histopathologic examination revealed the high predictive value of CT lymphographic-guided SLN biopsy: Only one of the preoperatively identified SLNs in three patients and both SLNs and adjacent nodes in two patients were positive for metastasis; all resected nodes in the remaining four patients were negative. CONCLUSION: Endoscopic CT lymphography is a feasible method for visualizing the direct connection between and the accurate anatomic location of SLNs and lymphatic drainage vessels.
(キーワード): Aged / Animals / Contrast Media / Dogs / Endoscopy, Gastrointestinal / Esophageal Neoplasms / Feasibility Studies / Humans / Lymph Node Excision / Lymphatic Metastasis / Lymphography / Middle Aged / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1148/radiol.2373041578
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16304114; ● Search Scopus @ Elsevier (PMID): 16304114; ● Search Scopus @ Elsevier (DOI): 10.1148/radiol.2373041578

(DOI: 10.1148/radiol.2373041578, PubMed: 16304114) 長島由紀子, 三瓶訓子, 山本滋, 吉野茂文, 丹黒章, 岡正朗 :
乳癌術後補助化学療法(FEC療法)における免疫能および副作用の検討,
癌と化学療法, Vol.32, No.11, 1550-1552, 2005年.

(要約): BACKGROUND: FEC (5-FU+epirubicin+cyclophosphamide) therapy has been used as adjuvant chemotherapy for breast cancer patients with nodes positive. The aim of this study was to evaluate host immunity and side effects of the FEC therapy. The effect of oral administration of Lentinus edodes mycelia (LEM) was also observed. METHODS: Ten patients were enrolled in this study. The treatment with 5-FU (500 mg/m2), epirubicin (75 mg/m2) and cyclophosphamide (500 mg/m2) was administered every 21 days for 2 cycles, and LEM (9 g/day po) was administered during the 2nd cycle. RESULTS: NK cell activity and the number of white blood cells decreased on the 7th day after the therapy, and they recovered on the 21st day. However, this NK cell activity and the number of white blood cells didn't decrease when the FEC therapy was used with LEM po. CONCLUSIONS: FEC 75 therapy has made some impacts on host immunity, and LEM with the FEC 75 therapy might have prevented host immunity.
(キーワード): Adult / Antineoplastic Combined Chemotherapy Protocols / Breast Neoplasms / Chemotherapy, Adjuvant / Cyclophosphamide / Epirubicin / Female / Fluorouracil / Fungal Proteins / Humans / Middle Aged / Polysaccharides
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16315865; ● Search Scopus @ Elsevier (PMID): 16315865

(PubMed: 16315865) Kazuya Kondo, Takanori Miyoshi, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Photodynamic therapy for submucosal tumor of the central bronchus,
The Journal of Medical Investigation : JMI, Vol.52, No.3,4, 208-211, 2005.

(要約): A 75-year-old man was referred to our hospital because of the emphysema and tumor of the right intermediate bronchus. Thoracic CT scan and bronchoscopic examination demonstrated a spherical tumor of the right intermediate bronchus covering a normal mucosa. The biopsy specimen obtained from this tumor was histologically diagnosed as "glandular type of adenocarcinoma in the bronchus". Surgical treatment was not feasible because of poor pulmonary function. Therefore, the patient underwent Photodynamic therapy (PDT) using porfimer sodium (Photofrin) and an excimer dye laser. After 4 months, the tumor disappeared and there has been no recurrence for 3 years 3 months. PDT can affect a submucosal tumor of the central airway, and is safe for patients with poor pulmonary function. Our report recommends that PDT should be applied not only to early lung cancer but also submucosal tumor of the central bronchus.
(キーワード): photodynamic thera / 肺癌 (lung cancer) / submucosal tumor / central airway
(徳島大学機関リポジトリ): ● Metadata: 110779
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.52.208
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16167540; ● Search Scopus @ Elsevier (PMID): 16167540; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.52.208

(徳島大学機関リポジトリ: 110779, DOI: 10.2152/jmi.52.208, PubMed: 16167540) 滝沢宏光, 中野基一郎, 監﨑孝一郎, 駒木幹正, 森本忠興, 丹黒章 :
甲状腺髄様癌術後肝転移に対し肝動脈化学塞栓療法が有効であった1例,
日本臨床外科学会雑誌, Vol.66, No.7, 1709-1712, 2005年.

(キーワード): 甲状腺髄様癌 / 転移性肝癌 / 肝動脈化学塞栓療法
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.66.1709
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204849234560; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.66.1709

(DOI: 10.3919/jjsa.66.1709, CiNii: 1390001204849234560) Kazuyoshi Suga, Shigeru Yamamoto, Akira Tangoku, Masaaki Oka, Yasuhiko Kawakami and Naofumi Matsunaga :
Breast sentinel lymph node navigation with three-dimensional interstitial multidetector-row computed tomographic lymphography.,
Investigative Radiology, Vol.40, No.6, 336-342, 2005.

(要約): OBJECTIVE: Three-dimensional multidetector-row computed tomographic lymphography (3D MDCT-LG) with interstitial injection of a widely available nonionic monometric contrast medium iopamidol was used for navigation of breast sentinel lymph node (SLN) biopsy. METHODS: 3D MDCT-LG was obtained after massage of the interstitially injection sites of a total of 4-5 mL undiluted iopamidol at periareolar and peritumoral areas in 68 consecutive patients with early-stage breast cancer, using a 4 detector-row CT scanner. Drainage lymphatic patterns and SLN anatomy were assessed on 3D MDCT-LG images. 3D MDCT-LG-navigated SLN biopsy with combined use of blue dye was followed by backup axillary lymph node dissection to evaluate accuracy of SLN biopsy. RESULTS: The 3D MDCT-LG images clearly localized primary SLNs by visualizing the direct connection between these nodes and their afferent lymphatic vessels on detailed anatomy of the surrounding structures in all patients. Drainage lymphatic pathways on these images were classified into 4 patterns: single route/single SLN (39 cases, 57%), multiple routes/multiple SLNs (10 cases, 15%), single route/multiple SLNs (9 cases, 13%), and multiple routes/single SLN (10 cases, 15%). Under 3D MDCT-LG navigation, SLNs was found at the accurate location in all patients. With backup axillary lymph node dissection, metastasis was found in 14 (20%) patients, and 8 of these patients had metastasis only in the preoperatively identified SLNs. In other 5 positive patients, metastasis was found both in the SLN and non-SLNs. However, micrometastasis eventually was found only in non-SLN in an elderly patient. Overall, the sensitivity, false-negative rate, and accuracy of 3D CT-L-navigated SLN biopsy were 92% (13/14 patients), 7% (1/14 patients), and 98% (67/68 patients), respectively. CONCLUSIONS: Topographic 3D interstitial MDCT-LG can be a widely available and reliable navigator for breast SLN biopsy.
(キーワード): Adult / Aged / Aged, 80 and over / Breast Neoplasms / Contrast Media / False Negative Reactions / Female / Humans / Imaging, Three-Dimensional / Iopamidol / Mammography / Middle Aged / Sensitivity and Specificity / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/01.rli.0000164153.41638.32
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15905719; ● Search Scopus @ Elsevier (PMID): 15905719; ● Search Scopus @ Elsevier (DOI): 10.1097/01.rli.0000164153.41638.32

(DOI: 10.1097/01.rli.0000164153.41638.32, PubMed: 15905719) Masatsugu Takehisa, Taeko Nagao, Mitsuteru Yoshida, Toshiyuki Hirose, Aiichiro Kajikawa, Mitsunori Sasa and Akira Tangoku :
Lower axillary dissection in breast cancer surgery may be candidate for cases with early breast cancer.,
The Journal of Medical Investigation : JMI, Vol.52, No.1-2, 74-79, 2005.

(要約): Lower axillary lymph node dissection (lower parts of both the level I and II elements below the second intracostobrachial nerve) and level I and II lymph node dissection were performed on breast cancer patients (n = 54), and the results with the two methods were compared in terms of the status of detected lymph node metastases. For Stage I, N0 cases, the results for pathological classification lymph node metastases (pN) were in agreement between the two dissection methods. And, the occurrence of operated arm swelling wasn't recognized when a side effect was examined with the case (n = 28) that only lower axillary dissection was carried out in case of an operation for breast cancer. Accordingly, it was surmised that lower axillary dissection provides accurate pN information for Stage I, N0 cases. These results indicate that lower axillary dissection has the potential to become an effective, standard surgical procedure for breast cancer patients whose preoperative disease stage is Stage I.
(キーワード): Adult / Aged / Axilla / Breast Neoplasms / Female / Humans / Lymph Node Excision / Lymphatic Metastasis / Middle Aged / Neoplasm Staging
(徳島大学機関リポジトリ): ● Metadata: 110759
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.52.74
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15751276; ● Search Scopus @ Elsevier (PMID): 15751276; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.52.74

(徳島大学機関リポジトリ: 110759, DOI: 10.2152/jmi.52.74, PubMed: 15751276) A Morimoto, E Yasuno, Y Kinouchi, Y Ohmine, Akira Tangoku and T Morimoto :
Spatial resolution in the electrical impedance tomography for the local tissue.,
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.6, 6638-6641, 2005.

(要約): Electrical impedance tomography (EIT) is one of the medical tissue diagnosis devices and it creates a two- or three-dimensional image of electrical impedance distribution in a living tissue. It is used for imaging the information of tissue structures, and physiological functions and states of the tissue. However, there are several problems to achieve the practical use of EIT, which are an inverse algorithm for estimating parameters and electrode structure and so on. EIT is calculated from impedance data, which is measured non-invasively by surface electrodes. Therefore, it is important to choose a proper electrode structure to realize a practical EIT measurement system. In this study, we used a electrode structure, called "divided electrode", which is proposed for a short time measurement of bio-impedance in a cross section of the local tissue. Its capability is examined by computer simulations, where a distributed equivalent circuit is used as a model for the cross section tissue. Estimation of impedance parameters is carried out by use of the Newton method. The objective of this study is to examine the spatial resolution on the circuit model. Moreover, the current flowing in the circuit model is examined.
(出版サイトへのリンク): ● Publication site (DOI): 10.1109/IEMBS.2005.1616024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17281794; ● Summary page in Scopus @ Elsevier: 2-s2.0-33846900947

(DOI: 10.1109/IEMBS.2005.1616024, PubMed: 17281794, Elsevier: Scopus) Yoshitaka Maeda, Minekatsu Nishida, Takashi Takao, Naohide Mori, Takao Tamesa, Akira Tangoku and Masaaki Oka :
Risk factors for postoperative liver failure after hepatectomy for hepatocellular carcinoma.,
Hepato-Gastroenterology, Vol.51, No.60, 1792-1796, 2004.

(要約): BACKGROUND/AIMS: Selection of patients for hepatectomy for hepatocellular carcinoma conventionally has been based upon Child-Pugh grading. However, postoperative liver failure after hepatectomy is a major cause of hospital mortality. A new predictor of postoperative liver failure is required. The objective of this study was to identify risk factors for postoperative liver failure after hepatectomy. METHODOLOGY: Perioperative risk factors for liver failure after hepatectomy were analyzed in 112 patients with hepatocellular carcinoma Eight of these patients died of liver failure. Stepwise multivariate logistic regression was performed to investigate significant independent factors among 17 variables, including the serum alkaline phosphatase ratio (ALPR) on the first day after hepatectomy. ALPR was calculated as the postoperative ALP level divided by the ALP level before surgery. RESULTS: Significant risk factors of postoperative liver failure were ALPR on postoperative day 1 (ALPR1), sex, operative blood loss, and operative procedure. As an indicator of liver failure, the diagnostic accuracy of the ALPR1 was 93.7% when the ALPR was less than 0.4 on the first postoperative day. The ALPR and the serum total bilirubin concentration after hepatectomy were uncorrelated. CONCLUSIONS: ALPR1 is a useful predictor of liver failure after hepatectomy.
(キーワード): Aged / Alkaline Phosphatase / Biological Markers / Carcinoma, Hepatocellular / Chi-Square Distribution / Cohort Studies / Female / Follow-Up Studies / Hepatectomy / Hospital Mortality / Humans / Liver Failure, Acute / Liver Function Tests / Liver Neoplasms / Logistic Models / Male / Middle Aged / Neoplasm Staging / Postoperative Complications / Predictive Value of Tests / Retrospective Studies / Risk Factors / Severity of Illness Index / Statistics, Nonparametric / Survival Analysis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15532828; ● Search Scopus @ Elsevier (PMID): 15532828

(PubMed: 15532828) Hiroaki Toshimitsu, Kiichiro Hashimoto, Akira Tangoku, Norio Iizuka, Kohtaro Yamamoto, Shigeto Kawauchi, Atsunori Oga, Tomoko Furuya, Masaaki Oka and Kohsuke Sasaki :
Molecular signature linked to acquired resistance to cisplatin in esophageal cancer cells.,
Cancer Letters, Vol.211, No.1, 69-78, 2004.

(要約): To clarify the molecular basis of acquired cisplatin (CDDP) resistance in esophageal squamous cell carcinoma (ESCC), we used cDNA microarray technology. A CDDP-resistant cell line (YES-2/CDDP), which shows a 7.5-fold increase in resistance to CDDP and a 3-fold decrease in CDDP accumulation compared with the parental YES-2 ESCC cell line, was generated from YES-2 by exposure to increased concentrations of CDDP. By cDNA microarray analysis, we identified 44 genes with significantly different expression levels between YES-2/CDDP and YES-2 cells. Interestingly, 15 of these 44 genes encoded ribosome-related proteins, almost all of which were underexpressed in YES-2/CDDP cells. Our present data suggest that many ribosome-related genes may be involved in the acquired resistance to CDDP in ESCC and that such information may allow us to better understand the mechanism of CDDP resistance.
(キーワード): Antineoplastic Agents / Carcinoma, Squamous Cell / 細胞周期 (cell cycle) / Cell Line, Tumor / Chromosome Aberrations / Cisplatin / DNA Fragmentation / Drug Resistance, Neoplasm / Esophageal Neoplasms / Gene Dosage / 遺伝子発現 (gene expression) / Humans / Oligonucleotide Array Sequence Analysis / Reverse Transcriptase Polymerase Chain Reaction
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.canlet.2004.01.038
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15194218; ● Search Scopus @ Elsevier (PMID): 15194218; ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2004.01.038

(DOI: 10.1016/j.canlet.2004.01.038, PubMed: 15194218) Akira Tangoku, Sigefumi Yoshino, Toshihiro Abe, Hideto Hayashi, T Satou, Tomio Ueno and Masaaki Oka :
Mediastinoscope-assisted transhiatal esophagectomy for esophageal cancer,
Surgical Endoscopy, Vol.18, No.3, 383-389, 2004.

(キーワード): Esophageal Cancer / Transthoracic Esophagectomy / Transhiatal Esophagectomy / Mediastinoscope / Minimally Invasive Surgery / Lymph Node Dissection
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00464-003-8181-2
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1360292619146372608; ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-003-8181-2

(DOI: 10.1007/s00464-003-8181-2, CiNii: 1360292619146372608) Norio Iizuka, Masaaki Oka, Hisafumi Yamada-Okabe, Kenji Hamada, Hironobu Nakayama, Naohide Mori, Takao Tamesa, Toshimasa Okada, Norikazu Takemoto, Katsuhiro Matoba, Motonari Takashima, Katsuhiko Sakamoto, Akira Tangoku, Takanobu Miyamoto, Shunji Uchimura and Yoshihiko Hamamoto :
Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray,
International Journal of Oncology, Vol.24, No.3, 565-574, 2004.

(要約): Chronic infection with hepatitis B or C virus (HBV or HCV) is the most clearly established risk factor for hepato-cellular carcinoma (HCC). One type of HCC (non-B, non-C HCC) also appears to develop in patients negative for both HBV and HCV. Using a supervised learning method, we investigated gene expression in 11 non-B, non-C HCCs with high-density oligonucleotide microarrays, and compared the patterns of gene expression with those of HBV-infected HCCs (B-type HCCs) and HCV-infected HCCs (C-type HCCs) in the previous dataset. Our gene selection identified 112 and 64 genes that were differentially expressed in non-B, non-C HCC in comparison with B- and C-type HCCs, respectively. In both gene selections, we found that the false discovery rate, the percentage of genes identified by chance, was less than 5%. Additionally, in combination with the previous data, our present data revealed a set of genes specific to each type of B- and C-type HCCs and non-B, non-C HCC. Among these, an interferon-induced gene, IFI27, was differentially expressed among all three types of HCCs, and this result was confirmed by RT-PCR. Thus, our present study provides a framework to characterize the molecular features in the three subtypes of HCC with different viral origin.
(キーワード): DNA Chip / Microarray / Gene Expression Profiles / Hepatocellular Carcinoma / Hepatitis B Virus / Hepatitis C Virus
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14767541; ● Search Scopus @ Elsevier (PMID): 14767541

(PubMed: 14767541) Akira Tangoku, Shigeru Yamamoto, Kazuyoshi Suga, Katsuhiko Ueda, Yukiko Nagashima, Makoto Hida, Tomomitsu Sato, Kazuhiko Sakamoto and Masaaki Oka :
Sentinel lymph node biopsy using computed tomography-lymphography in patients with breast cancer,
Surgery, Vol.135, No.3, 258-265, 2004.

(要約): The sentinel lymph node biopsy (SLNB) technique is established in the treatment of breast cancer. The current technique of mapping the SLN with blue dye or radiotracers requires a learning period. Tracer and injection site selection and intraoperative pathologic examination have been discussed. We developed a three-dimensional computed tomography lymphography (3D CT-LG) technique with commercially available iopamidol. SLNB and backup dissection were performed in 40 patients with T1 and T2 breast cancer. Feasibility and efficacy of CT-LG were examined. In all patients, lymph flow and the surrounding anatomical environment were visualized with 3D CT-LG. SLNB was successful because of accurate navigation by 3D CT-LG. SLN was detected in all patients, whereas dye navigation failed in seven fatty axilla and two patients with prior excisional biopsy. Backup dissection confirmed the accuracy of CT-LG-guided SLNB. A false negative result was found in only one patient. Preoperative prediction was feasible in cases of SLN metastasis. CT-LG allowed accurate SLN localization by quickly and adequately visualizing the direct connection between the SLN and its afferent lymphatic vessels. Detailed cross-sectional images of lymphatic anatomy during CT resulted in successful SLNB with shortening of the presurgical examination schedule.
(キーワード): Adult / Aged / Breast Neoplasms / Breast Neoplasms, Male / Female / Humans / Lymphography / Male / Middle Aged / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.surg.2003.07.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14976475; ● Search Scopus @ Elsevier (PMID): 14976475; ● Search Scopus @ Elsevier (DOI): 10.1016/j.surg.2003.07.003

(DOI: 10.1016/j.surg.2003.07.003, PubMed: 14976475) Kazuyoshi Suga, Yue Yuan, Munemasa Okada, Naofumi Matsunaga, Akira Tangoku, Shigeru Yamamoto and Masaaki Oka :
Breast sentinel lymph node mapping at CT lymphography with iopamidol: preliminary experience,
Radiology, Vol.230, No.2, 543-552, 2004.

(要約): To evaluate sentinel lymph node (SLN) mapping with interstitial computed tomographic (CT) lymphography with small volumes of iopamidol for direction of SLN biopsy in breast cancer. Thin-section transverse and three-dimensional CT images that included the breast and axilla were acquired at multi-detector row helical CT in 17 patients with operable breast cancer before subcutaneous injection of 2 mL of undiluted iopamidol into peritumoral and periareolar areas and 1-5 minutes after massage of injection sites. Location and size of SLNs were assessed at CT lymphography and were compared with SLNs at standard axillary lymph node dissection with blue dye staining. CT lymphography allowed localization of SLNs in all patients by means of visualization of a direct connection between an SLN and its afferent lymphatic vessels draining from the injection sites. Afferent vessels were joined and drained into a single axillary SLN, except in four patients with two or three SLNs, including a parasternal one. SLNs did not enhance because of rerouting of lymph flow in four patients. At surgery, SLNs that were stained or not stained with blue dye were easily found with CT lymphographic guidance. Tumoral infiltration was not evident in any resected nodes, except for infiltration in one patient with micrometastasis in SLN alone and infiltration in four patients with massive metastasis in both SLN and distant nodes. Because preoperative CT lymphography-guided SLN mapping provides SLN position with detailed lymphatic anatomy, it may be useful for the direction of breast SLN biopsy.
(キーワード): Adult / Aged / Biopsy, Needle / Breast Neoplasms / Contrast Media / Female / Humans / Imaging, Three-Dimensional / Iopamidol / Lymph Node Excision / Lymph Nodes / Lymphography / Mastectomy, Modified Radical / Mastectomy, Segmental / Middle Aged / Neoplasm Staging / Radiographic Image Enhancement / Radiographic Image Interpretation, Computer-Assisted / Sensitivity and Specificity / Sentinel Lymph Node Biopsy / Surgery, Computer-Assisted / Tomography, Spiral Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1148/radiol.2302021380
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14699178; ● CiNii @ 国立情報学研究所 (CRID): 1362825894625394944; ● Search Scopus @ Elsevier (PMID): 14699178; ● Search Scopus @ Elsevier (DOI): 10.1148/radiol.2302021380

(DOI: 10.1148/radiol.2302021380, PubMed: 14699178, CiNii: 1362825894625394944) Kiichiro Hashimoto, Naohide Mori, Takao Tamesa, Toshimasa Okada, Shigeto Kawauchi, Atsunori Oga, Tomoko Furuya, Akira Tangoku, Masaaki Oka and Kohsuke Sasaki :
Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH,
Modern Pathology, Vol.17, No.6, 617-622, 2004.

(要約): To clarify the genetic aberrations involved in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCV-HCC), we investigated DNA copy number aberrations (DCNAs) in 19 surgically resected HCCs by conventional CGH and array CGH. Conventional CGH revealed that increases of DNA copy number were frequent at 1q (79% of the cases), 8q (37%), 6p (32%), and 10p (32%) and that decreases were frequent at 17p (79%), 16q (58%), 4q (53%), 13q (42%), 10q (37%), 1p (32%), and 8p (32%). In general, genes that showed DCNAs by array CGH were usually located in chromosomal regions with DCNAs detected by conventional CGH analysis. Increases in copy numbers of the LAMC2, TGFB2, and AKT3 genes (located on 1q) and decreases in copy numbers of FGR/SRC2 and CYLD (located on 1p and 16q, respectively) were observed in more than 30% of tumors, including small, well-differentiated carcinomas. These findings suggest that these genes are associated with the development of HCV-HCC. Increases of MOS, MYC, EXT1, and PTK2 (located on 8q) were detected exclusively in moderately and poorly differentiated tumors, suggesting that these alterations contribute to tumor progression. In conclusion, chromosomal and array CGH technologies allow identification of genes involved in the development and progression of HCV-HCC.
(キーワード): hepatocellular carcinoma / hepatitis C virus / Carcinogenesis / Comparative Genomic Hybridization / Array CGH
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/modpathol.3800107
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15133472; ● Search Scopus @ Elsevier (PMID): 15133472; ● Search Scopus @ Elsevier (DOI): 10.1038/modpathol.3800107

(DOI: 10.1038/modpathol.3800107, PubMed: 15133472) Norio Iizuka, Masaaki Oka, Yoshihiko Hamamoto, Naohide Mori, Takao Tamesa, Akira Tangoku, Takanobu Miyamoto, Shunji Uchimura, Hironobu Nakayama, Kenji Hamada and Hisafumi Yamada-Okabe :
Altered Levels of Cytochrome P450 Genes in Hepatitis B or C Virus-infected Liver Identified by Oligonucleotide Microarray,
Cancer Genomics & Proteomics, Vol.1, No.1, 53-58, 2004.

(キーワード): DNA chip / Cytochrome P450 / HBV / HCV / Hepatocellular Carcinoma
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-20144387145

(Elsevier: Scopus) Toshimasa Okada, Norio Iizuka, Hisafumi Yamada-Okabe, Naohide Mori, Takao Tamesa, Norikazu Takemoto, Akira Tangoku, Kenji Hamada, Hironobu Nakayama, Takanobu Miyamoto, Shunji Uchimura, Yoshihiko Hamamoto and Masaaki Oka :
Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma,
FEBS Letters, Vol.555, No.3, 583-590, 2003.

(要約): To clarify the role of p53 in 22 hepatitis C virus (HCV)-infected hepatocellular carcinomas (HCCs), we compared the gene expression profiles of HCCs with wild-type p53 (wt-p53) (n=17) and those with mutant-type p53 (mt-p53) (n=5) by oligonucleotide microarray analysis. Among 83 p53-related genes identified by a supervised learning method, 25 were underexpressed, and 58 were overexpressed in mt-p53 HCCs compared with wt-p53 HCCs. With a computer search, we identified consensus p53-binding sequences in the 3-kb region upstream of the translation initiation site in 59 of the 83 genes, suggesting that the in vivo p53-associated transcription system is very complicated. These data will provide additional insights into p53-related pathogenesis in HCV-infected HCC.
(キーワード): p53 / DNA chip / 遺伝子発現 (gene expression) / Hepatocellular carcinoma / 癌 (cancer)
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0014-5793(03)01345-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14675778; ● Search Scopus @ Elsevier (PMID): 14675778; ● Search Scopus @ Elsevier (DOI): 10.1016/S0014-5793(03)01345-0

(DOI: 10.1016/S0014-5793(03)01345-0, PubMed: 14675778) Norio Iizuka, Masaaki Oka, Kohtaro Yamamoto, Akira Tangoku, Koji Miyamoto, Takanobu Miyamoto, Shunji Uchimura, Yoshihiko Hamamoto and Kiwamu Okita :
Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray,
International Journal of Cancer, Vol.107, No.4, 666-672, 2003.

(要約): Although the physiological actions of many herbs are gradually being elucidated at the molecular level, it remains unclear how individual components of herbs contribute to their biological activities. In the present study, the antiproliferative activity of Coptidis rhizoma, a medicinal herb, and the major component berberine was investigated in 8 human pancreatic cancer cell lines. Gene expression patterns associated with sensitivities to each agent were analyzed with oligonucleotide arrays that comprised approximately 11,000 genes. We used a tetrazolium dye (MTT) assay to determine ID(50) values after the 8 cell lines were exposed to the 2 agents for 72 hr. The ID(50) value for berberine was correlated positively with that for C. rhizoma (r=0.725, p=0.0401). C. rhizoma killed tumor cells more effectively than purified berberine when normalized to the level of berberine present in the herb. From the oligonucleotide array data, we selected 20 and 13 genes with strong correlations (r(2)>0.81) to ID(50) values for berberine and C. rhizoma, respectively. Among these 33 genes, the levels of expression of 12 were correlated with the ID(50) values of both agents, suggesting that these genes are associated with tumor-killing activity of berberine in C. rhizoma. Expression of the remaining 21 genes was correlated with the ID(50) value of either purified berberine or C. rhizoma. Thus, we identified common and distinct genes responsible for anti-proliferative activities of purified berberine and C. rhizoma. This strategy may improve our understanding of the actions of herbs with antitumor activities.
(キーワード): Coptidis rhizoma / Herb / Berberine / DNA chip / Pancreatic cancer
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ijc.11452
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14520708; ● Search Scopus @ Elsevier (PMID): 14520708; ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.11452

(DOI: 10.1002/ijc.11452, PubMed: 14520708) Takashi Ueno, Akira Tangoku, Shigefumi Yoshino, Toshihiro Abe, Hideto Hayashi, Hiroaki Toshimitsu, Kiichiro Hashimoto, Tomomitsu Satoh, Atsunori Oga, Tomoko Furuya, Masaaki Oka and Kohsuke Sasaki :
Prediction of nodal metastasis by comparative genomic hybridization in biopsy specimens from patients with superficial esophageal squamous cell carcinoma,
Clinical Cancer Research, Vol.9, No.14, 5137-5141, 2003.

(要約): Selection of appropriate protocols for treatment of superficial esophageal squamous cell carcinoma (SESCC) is dependent on lymph node metastasis status. Therefore, it is important to know whether lymph node metastasis is present before treatment. In this study, we examined the relation between DNA sequence copy number aberrations detected by comparative genomic hybridization and lymph node metastasis in 26 surgically resected SESCCs (training samples). We then assessed whether the genetic information is predictive for nodal status in biopsy specimens from eight newly enrolled patients with SESCC (blinded samples). Pathological examination revealed that 17 of 26 training samples (65.4%) did not have associated lymph node metastasis. Gains of 8q24 and/or 20q12-qter were observed in 12, including all (nine of nine) with nodal metastasis. Fourteen training samples did not have gain of either 8q24 or 20q12-qter. Of the blinded samples, two showed no gain of 8q24 or 20q12-qter, and as anticipated the postoperative pathological examination revealed no nodal metastasis. The remaining six blinded samples had gains of 8q24 and/or 20q12-qter, and lymph node metastasis was detected by postoperative examination in four of these tumors. Absence of gains of 8q24 and/or 20q12-qter appears to be associated with absence of lymph node metastasis in patients with SESCC; therefore, less invasive surgery can be chosen.
(キーワード): Aged / Aged, 80 and over / Biopsy, Needle / Carcinoma, Squamous Cell / Chromosomes, Human, Pair 20 / Chromosomes, Human, Pair 8 / DNA, Neoplasm / Esophageal Neoplasms / Female / Gene Amplification / Humans / Lymph Nodes / Lymphatic Metastasis / Male / Middle Aged / Nucleic Acid Hybridization / Postoperative Care / Predictive Value of Tests
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14613991; ● Search Scopus @ Elsevier (PMID): 14613991

(PubMed: 14613991) Hiroshi Araki, Takashi Ueno, Akira Tangoku, Shugefumi Yoshino, Toshihiro Abe, Shigeto Kawauchi, Atsunori Oga, Tomoko Furuya, Masaaki Oka and Kohsuke Sasaki :
Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma:comparison with conventional comparative genomic hybridization analysis,
Cancer Genetics and Cytogenetics, Vol.146, No.1, 16-21, 2003.

(要約): Oncogene amplification in 20 surgically resected esophageal squamous cell carcinomas (ESCC) was examined with DNA microarrays that detected 57 oncogenes and two reference DNA. Alterations in DNA copy numbers detected by microarrays were compared to those obtained by conventional comparative genomic hybridization (CGH). Amplification of eight oncogenes (CCND1, FGF3/FGF4, EMS1, SAS, ERBB2, PDGFRA, MYC, and BCL2) was detected by DNA microarrays in 9 of 20 tumors. Although ERBB2 was 23.2 times higher than the control level in one case, the average magnitude of gene amplification was approximately two to four times that of the control level. EMS1, CCND1, and FGF3/FGF4, which are all located on 11q13, were amplified in 7, 5, and 4 of 20 ESCC, respectively, and they were coamplified in 3 tumors. A comparison of genome DNA microarrays and CGH data revealed that although most amplified oncogenes were included in chromosomal regions for which DNA copy number gains were detected by conventional CGH, not all amplified genes on microarrays showed concomitant DNA copy number gains on CGH. In conclusion, microarrays of oncogenes are useful for the comprehensive identification of amplified oncogenes and for analysis of areas of specific amplification within chromosomal regions with DNA copy number increases detected by CGH analysis.
(キーワード): Aged / Aged, 80 and over / Carcinoma, Squamous Cell / DNA / Esophageal Neoplasms / Female / Gene Amplification / Humans / Male / Middle Aged / Nucleic Acid Hybridization / Oligonucleotide Array Sequence Analysis / Oncogenes
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0165-4608(03)00106-7
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14499691; ● Search Scopus @ Elsevier (PMID): 14499691; ● Search Scopus @ Elsevier (DOI): 10.1016/S0165-4608(03)00106-7

(DOI: 10.1016/S0165-4608(03)00106-7, PubMed: 14499691) 河岡徹, 吉野茂文, 硲彰一, 丹黒章, 岡正朗 :
癌性胸腹水に対するLentinan+OK-432併用療法の臨床的検討,
癌と化学療法, Vol.30, No.11, 1562-1565, 2003年.

(要約): It is very important to control the Th2-dominant condition in cancer patients while they are undergoing immunotherapy. OK-432 powerfully guides Th1 cytokine, but sometimes it can not eliminate the Th2 dominant state in cancer patients, which is needed to induce Th2 cytokine. Premedication with combined LTN and OK-432 is an effective therapy for controlling the Th1/Th2 balance. We tried administering LTN and OK-432 in the pleural or peritoneal cavity for patients with malignant effusion. Of all 9 lesions of the 8 cases, 6 showed complete remission and 1 showed partial response. The level of IL-12 (p70) and IFN-gamma in the pleural effusion or ascites of the combination group was higher than the OK-432 only group. In conclusion, LTN and OK-432 combined therapy appears to be an effective local treatment.
(キーワード): Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Breast Neoplasms / Female / Humans / Immunotherapy / Interferon-gamma / Interleukin-10 / Interleukin-12 / Lentinan / Male / Middle Aged / Picibanil / Pleural Effusion, Malignant / Stomach Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14619464; ● Search Scopus @ Elsevier (PMID): 14619464

(PubMed: 14619464) 為佐卓夫, 森尚秀, 岡田敏正, 竹本紀一, 坂本和彦, 山崎隆弘, 丹黒章, 岡正朗 :
Vp4肝細胞癌術後Low-Dose CDDP+5-FU肝動注療法が肝内再発に有効であった1例,
癌と化学療法, Vol.30, No.11, 1769-1772, 2003年.

(要約): A 49-year-old woman was admitted to our hospital because of hepatocellular carcinoma (HCC). She had no hepatitis virus. Serum AFP and PIVKA-II levels were as high as AFP 329.4 ng/ml (AFP-L3% 73.1%) and 281 AU, respectively. Portal venous thrombus was observed from the right portal branch to left portal branch and superior mesenteric vein. An extended right hemihepatectomy with extraction of portal venous thrombus was performed. On postoperative day 8, low-dose cisplatin (10 mg/day for 5 days/week) and 5-fluorouracil (250 mg/day for 5 days/week) were administered through the hepatic artery for 4 weeks. After chemotherapy, one intrahepatic metastasis appeared and RFA was performed for this tumor. At 16 months after surgery, she had multiple lymph node metastases and died at 20 months after the surgery without intrahepatic metastasis. Low-dose CDDP/5-FU intra-hepatic artery infusion chemotherapy was effective for prevention of intrahepatic recurrence after resection of HCC with portal venous thrombus.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Hepatocellular / Cisplatin / Drug Administration Schedule / Female / Fluorouracil / Hepatectomy / Hepatic Artery / Humans / Infusions, Intra-Arterial / Liver Neoplasms / Middle Aged / Neoplasm Recurrence, Local / Neoplastic Cells, Circulating
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14619515; ● Search Scopus @ Elsevier (PMID): 14619515

(PubMed: 14619515) 加藤雅俊, 硲彰一, 坂本和彦, 吉野茂文, 丹黒章, 岡正朗 :
肝癌切除の手術侵襲評価におけるCD4陽性リンパ球内サイトカイン測定の意義,
癌と化学療法, Vol.30, No.11, 1848-1850, 2003年.

(要約): It is difficult to evaluate surgical stress of patients with hepatocellular carcinoma (HCC). Cytokine production from the liver is decreased due to the liver dysfunction that is usually associated with HCCs. Therefore, we evaluated surgical stress after hepatectomy by measuring intracellular cytokines of lymphocytes in peripheral blood. We examined 22 patients with digestive cancers (8 with HCC, 10 with gastric cancer, and 4 with esophageal cancer). The concentrations of serum IL-6 levels 6 h after hepatectomy, gastrectomy, and esophagectomy were 268 +/- 84, 309 +/- 93, and 1,323 +/- 364 pg/ml, respectively. There was no significant difference between hepatectomy and gastrectomy, though based on clinical observations, it is estimated the surgical stress of hepatectomy was greater than that of gastrectomy. Conversely, the percentage of CD4+IL-6+ cells 6 h after surgery was 8.5 +/- 2.8, 3.3 +/- 0.6, and 7.8 +/- 3.4%, respectively. The percentage of CD4+IL-6+ cells after hepatectomy was significantly higher than that after gastrectomy. We estimated that the percentage of CD4+IL-6+ cells was an appropriate indicator of surgical stress on HCC, because the percentage of CD4+IL-6+ cells correlated well with the duration of surgery more than did the serum IL-6 levels. These results suggest that the percentage of CD4+IL-6+ cells may help in accurately evaluating surgical stress in patients with liver dysfunctions such as HCC.
(キーワード): CD4-Positive T-Lymphocytes / Carcinoma, Hepatocellular / 細胞質分裂 (cytokinesis) / Esophageal Neoplasms / Hepatectomy / Humans / Interleukin-6 / Liver Neoplasms / Lymphocytes / Stomach Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14619536; ● Search Scopus @ Elsevier (PMID): 14619536

(PubMed: 14619536) 安部俊弘, 丹黒章, 岡正朗 :
食道良性疾患の外科治療 6．食道憩室,
日本外科学会雑誌, Vol.104, No.9, 601-605, 2003年.

(要約): Esophageal diverticula are considered to be rare but this has not deterred interest in the condition, either historically or in the present era. Most parabronchial esophageal diverticula are traction diverticula, and resection is thought to be unnecessary. The majority of pharyngoesophageal diverticula and epiphrenic diverticula are pulsion diverticula. It is now well accepted that they correlate with underlying motor disturbance and that surgery is indicated. If there is motor disturbance is preoperative manometry, it is necessary to add myotomy. However, if there is no motor disturbance, the surgical management remains controversial. Recently, minimal access surgery with laparoscopy or thoracoscopy has been successful in the treatment of epiphrenic diverticulum.
(キーワード): Diverticulum, Esophageal / Esophagectomy / Esophagus / Humans / Laparoscopy / Manometry / Surgical Procedures, Minimally Invasive / Thoracoscopy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14574714; ● Search Scopus @ Elsevier (PMID): 14574714

(PubMed: 14574714) Norio lizuka, Masaaki Oka, Hisafumi Yamada-0kabe, Naohide Mori, Takao Tamesa, Toshimasa Okada, Norikazu Takemoto, Kiichiro Hashimoto, Akira Tangoku, Kenji Hamada, Hironobu Nakayama, Takanobu Miyamoto, Shunji Uchimura and Yoshihiko Hamamoto :
Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis,
Oncogene, Vol.22, No.19, 3007-3014, 2003.

(要約): Using oligonucleotide microarray data of 45 hepatocellular carcinoma (HCC) samples, we evaluated gene expression in hepatitis B virus-positive and hepatitis C virus-positive HCCs (HBV- and HCV-HCCs) for an association with liver cirrhosis (LC). In all, 89 genes were expressed differentially between HBV-HCCs associated with LC and those not associated with LC. Among them, tumors from LC patients showed significantly lower expression levels of 72 genes and significantly higher levels of 17 genes than the levels found in tumors from non-LC patients. The former included genes responsible for signal transduction, transcription, metabolism, and cell growth. The latter included a tumor suppressor gene and a cell-growth-related gene. Only eight genes were expressed differentially between HCV-HCCs associated with and without LC. Our findings provide as a framework for clarifying the role of LC in HBV- and HCV-related hepatocarcinogenesis.
(キーワード): DNA Chip / Gene Expression Profiles / HCC / HBV / Liver Cirrhosis
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/sj.onc.1206401
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12771952; ● Search Scopus @ Elsevier (PMID): 12771952; ● Search Scopus @ Elsevier (DOI): 10.1038/sj.onc.1206401

(DOI: 10.1038/sj.onc.1206401, PubMed: 12771952) Norio Iizuka, Masaaki Oka, Hisafumi Yamada-Okabe, Minekatsu Nishida, Yoshitaka Maeda, Naohide Mori, Takashi Takao, Takao Tamesa, Akira Tangoku, Hisahiro Tabuchi, Kenji Hamada, Hironobu Nakayama, Hideo Ishitsuka, Takanobu Miyamoto, Akira Hirabayashi, Shunji Uchimura and Yoshihiko Hamamoto :
Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection,
The Lancet, Vol.361, No.9361, 923-929, 2003.

(要約): Hepatocellular carcinoma has a poor prognosis because of the high intrahepatic recurrence rate. There are technological limitations to traditional methods such as TNM staging for accurate prediction of recurrence, suggesting that new techniques are needed. We investigated mRNA expression profiles in tissue specimens from a training set, comprising 33 patients with hepatocellular carcinoma, with high-density oligonucleotide microarrays representing about 6000 genes. We used this training set in a supervised learning manner to construct a predictive system, consisting of 12 genes, with the Fisher linear classifier. We then compared the predictive performance of our system with that of a predictive system with a support vector machine (SVM-based system) on a blinded set of samples from 27 newly enrolled patients. Early intrahepatic recurrence within 1 year after curative surgery occurred in 12 (36%) and eight (30%) patients in the training and blinded sets, respectively. Our system correctly predicted early intrahepatic recurrence or non-recurrence in 25 (93%) of 27 samples in the blinded set and had a positive predictive value of 88% and a negative predictive value of 95%. By contrast, the SVM-based system predicted early intrahepatic recurrence or non-recurrence correctly in only 16 (60%) individuals in the blinded set, and the result yielded a positive predictive value of only 38% and a negative predictive value of 79%. Our system predicted early intrahepatic recurrence or non-recurrence for patients with hepatocellular carcinoma much more accurately than the SVM-based system, suggesting that our system could serve as a new method for characterising the metastatic potential of hepatocellular carcinoma.
(キーワード): Carcinoma, Hepatocellular / Female / Gene Expression Profiling / Humans / Liver Neoplasms / Male / Middle Aged / Neoplasm Recurrence, Local / Oligonucleotide Array Sequence Analysis / Predictive Value of Tests
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0140-6736(03)12775-4
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12648972; ● Search Scopus @ Elsevier (PMID): 12648972; ● Search Scopus @ Elsevier (DOI): 10.1016/S0140-6736(03)12775-4

(DOI: 10.1016/S0140-6736(03)12775-4, PubMed: 12648972) Kazuyoshi Suga, Nobuhiko Ogasawara, Yuan Yue, Munemasa Okada, Naofumi Matsunaga and Akira Tangoku :
Visualization of Breast Lymphatic Pathways With an Indirect Computed Tomography Lymphography Using a Nonionic Monometric Contrast Medium Iopamidol: Preliminary Results,
Investigative Radiology, Vol.38, No.2, 73-84, 2003.

(要約): The capability of an indirect computed tomographic lymphography (CT-LG) using a nonionic monometric contrast medium iopamidol for visualizing breast lymphatic pathways was preliminarily tested. In 10 female dogs, a total of 0.5 and 1 mL of undiluted iopamidol was injected subcutaneously into the skin areas overlying the both caudal mammary glands. Contiguous 2-mm-thick multidetector raw helical CT images were obtained through the upper thorax and axilla before and during 60 minutes after gentle massage at the injection sites, with reconstruction into three-dimensional (3D) postcontrast CT images. The first lymph node (1st LN) directly draining from the injection sites was marked under CT guidance, followed by pre- and postmortem examinations. This CT-LG with 2-mL iopamidol was also attempted in five human female volunteers. Even with 0.5-mL iopamidol, the CT-LG clearly visualized the direct connection of the 1st LN and lymphatic vessels draining from the injection sites throughout the examination time in all the animals, with the maximum CT attenuation of 269 Hounsfield units (HU) +/- 137 in the 1st LN on the first postcontrast images. The topographic 3D images provided comprehensive anatomic outlines of these lymphatic pathways. Of the total of 20 opacified 1st LN and 110 distant nodes, all the 1st LN (100%) and 92 (83.6%) distant nodes could be resected at pre- or postmortem, with a good correlation with the CT images. The CT-LG also effectively localized the 1st LN with the maximum attenuation of 223 HU +/- 63 in the human volunteers, without any significant late adverse effects. Indirect CT-LG with iopamidol may have excellent potential for visualizing breast lymphatic drainage and for preoperative localization of breast sentinel lymph nodes.
(キーワード): Adult / Animals / Breast / Contrast Media / Dogs / Female / Humans / Iopamidol / Linear Models / Lymph Nodes / Lymphography / Mammary Glands, Animal / Middle Aged / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/00004424-200302000-00002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12544070; ● Search Scopus @ Elsevier (PMID): 12544070; ● Search Scopus @ Elsevier (DOI): 10.1097/00004424-200302000-00002

(DOI: 10.1097/00004424-200302000-00002, PubMed: 12544070) Koji Matsuoka, Tomio Ueno, Katsuhiko Morita, Hiroo Kawano, Kazuhito Yamaguchi, Tsuyoshi Maekawa, Akira Tangoku and Masaaki Oka :
Effects of moderate hypothermia on proinflammatory cytokine production in a rat model of caerulein-induced pancreatitis,
Pancreas, Vol.26, No.1, e12-e17, 2003.

(要約): Proinflammatory cytokines act as mediators of the local and systemic manifestations of acute pancreatitis (AP). To investigate whether moderate hypothermia (MH) (32 degrees C) can reduce the severity of AP by inhibiting cytokine production in a rat model of caerulein-induced pancreatitis. Rats were divided into three groups: control rats (Group I), AP rats treated with normothermia (38 degrees C) (Group II), and AP rats treated with MH (Group III). AP was induced by intramuscular injection of caerulein and intraperitoneal infusion of lipopolysaccharide. MH was induced 4 hours after the first caerulein injection. Serum interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, IL-6, amylase, and lipase levels were determined 8 hours after the first injection. The pancreas and lung were examined histologically. MH in comparison with normothermia significantly reduced serum levels of IL-1beta, TNF-alpha, IL-6, amylase, and lipase. Histologically, the MH group showed less vacuolization of the acinar cells and cellular infiltration into the interacinar areas of the pancreas than were shown in the normothermia group, but these effects were not evident in the lung. Our results suggest that MH may be clinically applicable for reducing the severity of AP.
(キーワード): Acute Disease / Amylases / Animals / Blood Gas Analysis / Blood Pressure / Caerulein / Cytokines / Hypothermia, Induced / Interleukin-1 / Interleukin-6 / Lipase / Male / Pancreas / Pancreatitis / Rats / Rats, Wistar / Tumor Necrosis Factor-alpha
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12499932; ● Search Scopus @ Elsevier (PMID): 12499932

(PubMed: 12499932) Norio Iisuka, Naohide Mori, Takuo Tamesa, Akira Tangoku and Masaaki Oka :
Telomerase Activity and Nm23-H2 Protein Expression in Hepatocellular Carcinoma,
Anticancer Research, Vol.23, No.1A, 43-47, 2003.

(要約): Telomerase activity is up-regulated in most hepatocellular carcinomas (HCCs). Nm23-H2 has been shown to promote the expression of the c-myc gene, a candidate transcriptional activator of the human telomerase reverse transcriptase gene. Therefore, this study was undertaken to clarify the relationship between nm23-H2 expression and telomerase activity in HCCs. Telomerase activity and nm23-H2 protein expression in 24 HCCs were analyzed by telomeric repeat amplification protocol (TRAP) assay and immunohistochemistry, respectively. The incidence of positive telomerase activity was significantly higher in tumor tissues than in normal liver tissues (18 out of 24 vs. 7 out of 24, p = 0.0015), and nm23 -H2 protein was more abundantly expressed in tumors than in corresponding normal liver tissues. Tumor nm23-H2 immunoreactivity was associated positively with tumor telomerase activity (p = 0.0037). These results demonstrate that tumor nm23-H2 expression might be associated positively with telomerase activity in HCC and suggest the value of tumor nm23-H2 linked to telomerase activity as a therapeutic target for HCC.
(キーワード): Hepatocellular Carcinoma / nm23 / Nucleoside Diphosphate Kinase / Telomerase
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12680194; ● Search Scopus @ Elsevier (PMID): 12680194

(PubMed: 12680194) 吉村清, 硲彰一, 飯塚徳男, 高野尚史, 松岡功治, 丹黒章, 岡正朗 :
当科における大腸癌肝転移に対するIL‐2，5‐FU，MMC併用肝動注療法の経験,
癌と化学療法, Vol.29, No.12, 2117-2120, 2002年.

(要約): We administered interleukin (IL)-2 with mitomycin C (MMC) and 5-fluorouracil (5-FU) by hepatic arterial infusion for the treatment of liver recurrence from colorectal cancer. The regimen consisted of continuous hepatic arterial infusion of IL-2 (7 x 10(5) JRU/day)/5-FU (250 mg/day) for 4 weeks. After those 4 weeks, a weekly hepatic arterial infusion of IL-2 (2.1 x 10(6) JRU)/5-FU (250 mg) was performed more than 4 weeks. MMC (4 mg) was given as a bolus weekly. This therapy resulted in partial response (PR) in one case, progressive disease (PD) in one case, and no change (NC) in one case. The toxicity of the therapy was a slight in all cases. We herein report 3 patients treated with hepatic arterial infusion of IL-2 with MMC and 5-FU for liver recurrence from colorectal cancer. This therapy may be a new strategy for metastatic colorectal cancer.
(キーワード): Aged / Aged, 80 and over / Antimetabolites, Antineoplastic / Colectomy / Colorectal Neoplasms / Female / Fluorouracil / Humans / Infusions, Intra-Arterial / Liver Neoplasms / Survival Rate
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12484016; ● Search Scopus @ Elsevier (PMID): 12484016

(PubMed: 12484016) 山本光太郎, 矢原昇, 河岡徹, 林秀知, 硲彰一, 丹黒章, 岡正朗 :
胆道再建術後転移性肝癌に対してラジオ波焼灼療法(RFA)施行後に敗血症を来した1剖検例,
癌と化学療法, Vol.29, No.12, 2238-2241, 2002年.

(要約): An autopsy case of sepsis following radiofrequency ablation (RFA) for metastatic liver carcinoma after bile duct reconstructive operation is reported. A 72-year-old man underwent pylorus-preserving pancreaticoduodenectomy and reconstruction with the Suzuki-method (PD-III) for extrahepatic bile duct cancer in October 1998. A metastatic lesion was recognized in the liver (S3) in November 2001. Percutaneous RFA was performed for a recurrent lesion. A metastatic lesion was recognized again in the same segment in February 2002. Percutaneous RFA was performed again on February 26 and March 12. The patient was discharged without hemorrhage, infection, or hepatic failure on March 22. He complained of general fatigue on March 26. He was diagnosed with liver abscess, sepsis, acute renal failure, and disseminated intravascular coagulation, and received intensive care, but died on April 1. The autopsy revealed liver necrotic abscess at the RFA locus and multiple microabscesses of the liver, heart, and kidney.
(キーワード): Acute Kidney Injury / Aged / Bile Duct Neoplasms / Bile Ducts / Bile Ducts, Intrahepatic / Catheter Ablation / Disseminated Intravascular Coagulation / Humans / Liver Abscess / Liver Neoplasms / Male / Pancreaticoduodenectomy / Postoperative Complications / Sepsis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12484045; ● Search Scopus @ Elsevier (PMID): 12484045

(PubMed: 12484045) Mitsuo Nakamura, Masaaki Oka, Norio Iizuka, Shigeto Kawauchi, Toshikazu Gondo, Tomio Ueno and Akira Tangoku :
Osteopontin expression in chronic pancreatitis.,
Pancreas, Vol.25, No.2, 182-187, 2002.

(要約): Chronic pancreatitis (CP) is frequently associated with stone formation within the pancreatic duct system. The mechanism of pancreatic stone formation, however, is still unclear.
(キーワード): Adult / Aged / Calculi / Chronic Disease / Female / Gene Expression / Humans / Immunohistochemistry / Male / Middle Aged / Osteopontin / Pancreatitis / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Sialoglycoproteins
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12142743; ● Search Scopus @ Elsevier (PMID): 12142743

(PubMed: 12142743) Norio Iizuka, Masaaki Oka, Hisafumi Yamada-Okabe, Naohide Mori, Takao Tamesa, Toshimasa Okada, Norikazu Takemoto, Akira Tangoku, Kenji Hamada, Hironobu Nakayama, Takanobu Miyamoto, Shunji Uchimura and Yoshihiko Hamamoto :
Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method.,
Cancer Research, Vol.62, No.14, 3939-3944, 2002.

(要約): Gene expression profiles of hepatocellular carcinomas (HCCs) associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) were analyzed and compared. Oligonucleotide microarrays containing >6000 genes and subsequent gene selection by a supervised learning method yielded 83 genes for which expression differed between the two types of HCCs. Expression levels of 31 of these 83 genes were increased in HBV-associated HCCs, and expression levels of the remaining 52 genes were increased in HCV-associated HCCs. The 31 genes up-regulated in HBV-associated HCC included imprinted genes (H19 and IGF2) and genes relating to signal transduction, transcription, and metastasis. The 52 genes up-regulated in HCV-associated HCC included a number of genes responsible for detoxification and immune response. These results suggest that HBV and HCV cause hepatocarcinogenesis by different mechanisms and provide novel tools for diagnosis and treatment of HBV- and HCV-associated HCCs.
(キーワード): Aged / Carcinoma, Hepatocellular / Female / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Genomic Imprinting / Hepacivirus / Hepatitis B virus / Hepatitis B, Chronic / Hepatitis C, Chronic / Humans / Liver Neoplasms / Male / Middle Aged / Multigene Family / Oligonucleotide Array Sequence Analysis / Up-Regulation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12124323; ● Search Scopus @ Elsevier (PMID): 12124323

(PubMed: 12124323) N Yahara, T Abe, K Morita, Akira Tangoku and M Oka :
Comparison of interleukin-6, interleukin-8, and granulocyte colony-stimulating factor production by the peritoneum in laparoscopic and open surgery., --- Human mesothelial cells secrete a variety of cytokines. The levels of postoperative serum inflammatory cytokines are thought to reflect the magnitude of surgical stress. ---,
Surgical Endoscopy, Vol.16, No.11, 1615-1619, 2002.

(要約): Human mesothelial cells secrete a variety of cytokines. The levels of postoperative serum inflammatory cytokines are thought to reflect the magnitude of surgical stress. Pieces of peritoneum were obtained immediately upon and 1 h after entry into the abdominal cavity in nine patients undergoing laparoscopic surgery and 11 patients undergoing open surgery. The samples were cultured and interleukin (IL)-6, IL-8, and granylocyte colony-stimulating factor (G-CSF) levels in the supernatants were measured by enzyme-linked immunosorbent assay (ELISA). Expression of IL-6, IL-8, and G-CSF mRNAs was examined by RT-PCR. At 1 h after laparotomy, the amounts of IL-6 and G-CSF produced by the peritoneum were significantly greater than those obtained immediately after the procedure, but this difference was not observed with laparoscopic surgery. Reverse transcription-polymerase chain reaction (RT-PCR), which showed an increase in the expression of cytokine mRNAs at 1 h after laparotomy, was compatible with these results. The lower levels of cytokine production by the peritoneum suggest that laparoscopic surgery is associated with lower degree of surgical stress.
(キーワード): Adult / Aged / Culture Techniques / Female / Granulocyte Colony-Stimulating Factor / Humans / Interleukin-6 / Interleukin-8 / Laparoscopy / Male / Middle Aged / Peritoneum / Postoperative Period / RNA, Messenger / Surgical Procedures, Elective / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00464-001-8205-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12085139; ● Search Scopus @ Elsevier (PMID): 12085139; ● Search Scopus @ Elsevier (DOI): 10.1007/s00464-001-8205-8

(DOI: 10.1007/s00464-001-8205-8, PubMed: 12085139) Norio Iizuka, Shoichi Hazama, Kiyoshi Yoshimura, Shigefumi Yoshino, Akira Tangoku, Koji Miyamoto, Kiwamu Okita and Masaaki Oka :
Anticachectic effects of the natural herb Coptidis rhizoma and berberine on mice bearing colon 26/clone 20 adenocarcinoma.,
International Journal of Cancer, Vol.99, No.2, 286-291, 2002.

(要約): We previously showed that the natural herb Coptidis rhizoma has an anticachectic effect in nude mice bearing human esophageal cancer cells. We further investigated this phenomenon by examining the anticachectic effect of C. rhizoma in syngeneic mice bearing colon 26/clone 20 carcinoma cells, which cause IL-6-related cachexia after cell injection. We evaluated nutritional parameters such as serum glucose level and wasting of adipose tissue and muscle in tumor-bearing and non-tumor-bearing mice treated with C. rhizoma (CR) supplement or a normal diet. IL-6 levels in those mice were quantified by ELISA and real-time RT-PCR. CR supplementation significantly attenuated weight loss in tumor-bearing mice without changing food intake or tumor growth. Furthermore, these mice maintained good nutritional status. IL-6 mRNA levels in tumors and spleens and IL-6 protein levels in tumors and sera were significantly lower in tumor-bearing mice treated with CR supplement than in those treated with a normal diet. CR supplementation did not affect food intake, body weight, nutritional parameters and IL-6 levels in non-tumor-bearing mice. An in vitro study showed that C. rhizoma and its major component, berberine, inhibited IL-1-induced IL-6 mRNA expression in a dose-dependent manner in colon 26/clone 20 cells. Our results showed that C. rhizoma exerts an anticachectic effect on colon 26/clone 20-transplanted mice and that its effect is associated with tumor IL-6 production. We also suggest that its effect might be due to berberine.
(キーワード): Adenocarcinoma / Adipose Tissue / Animals / Berberine / Cachexia / Colonic Neoplasms / Drugs, Chinese Herbal / Enzyme-Linked Immunosorbent Assay / Gene Expression / Interleukin-1 / Interleukin-6 / Male / Mice / Mice, Inbred BALB C / Muscle, Skeletal / Neoplasm Transplantation / Nutritional Status / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Spleen / Weight Loss
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ijc.10338
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11979446; ● Search Scopus @ Elsevier (PMID): 11979446; ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.10338

(DOI: 10.1002/ijc.10338, PubMed: 11979446) Naofumi Takano, Norio Iizuka, Shoichi Hazama, Shigefumi Yoshino, Akira Tangoku and Masaaki Oka :
Expression of estrogen receptor-alpha and -beta mRNAs in human gastric cancer.,
Cancer Letters, Vol.176, No.2, 129-135, 2002.

(要約): To clarify the roles of estrogen receptors (ERs) in gastric cancers, we evaluated expression of ER-alpha and ER-beta mRNAs in 41 pairs of tumorous and non-tumorous tissues of gastric cancer patients and in six gastric cancer cell lines by reverse transcription-polymerase chain reaction method. ER-alpha and ER-beta mRNAs were detected in 21 (51%) and 30 (73%) of 41 tumors and in 15 (37%) and 36 (88%) of 41 corresponding normal tissues, respectively. There were no statistically significant associations between expression of ER-alpha and/or ER-beta mRNAs in tumors and clinicopathologic factors. Between the tumorous and normal tissues, expression of ER-alpha and ER-beta mRNAs were changed in 20 (49%) and unchanged in 21 (51%) of the 41 cases. The incidences of lymph node metastasis and liver metastasis were significantly higher in changed cases than in unchanged cases (P=0.031 and P=0.021, respectively). We confirmed that ER-alpha and ER-beta mRNA were expressed in 2 and 6 of the six gastric cancer cell lines, respectively. Together with this finding, our results indicate that ER-beta mRNAs are preferentially expressed in gastric cancers. Our data also suggest that altered expression of ER-alpha and ER-beta mRNAs in tumors compared with corresponding normal gastric tissues is related to increased metastatic potential in gastric cancers. Further studies are needed to clarify the role of ERs in gastric cancers.
(キーワード): Adult / Aged / Aged, 80 and over / Estrogen Receptor alpha / Estrogen Receptor beta / Female / Humans / Liver Neoplasms / Lymphatic Metastasis / Male / Middle Aged / RNA, Messenger / Receptors, Estrogen / Reverse Transcriptase Polymerase Chain Reaction / Signal Transduction / Stomach Neoplasms / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0304-3835(01)00739-X
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11804739; ● Search Scopus @ Elsevier (PMID): 11804739; ● Search Scopus @ Elsevier (DOI): 10.1016/S0304-3835(01)00739-X

(DOI: 10.1016/S0304-3835(01)00739-X, PubMed: 11804739) Takashi Ueno, Akira Tangoku, Shigefumi Yoshino, Toshihiro Abe, Hiroaki Toshimitsu, Tomoko Furuya, Shigeto Kawauchi, Atsunori Oga, Masaaki Oka and Kohsuke Sasaki :
Gain of 5p15 detected by comparative genomic hybridization as an independent marker of poor prognosis in patients with esophageal squamous cell carcinoma.,
Clinical Cancer Research, Vol.8, No.2, 526-533, 2002.

(要約): Comparative genomic hybridization was applied to 51 primary esophageal squamous cell carcinomas (ESCCs) to clarify the relation between DNA sequence copy number aberrations (DSCNAs) and the clinicopathology of the disease. The average number of DSCNAs was 10.9 DSCNAs/tumor (6.1 gains and 4.9 losses), ranging from 1-30 DSCNAs/tumor. Gain of 3q26-qter and loss of 18q22-qter were detected in >60% of stage I tumors and considered to play an important role in the development of ESCC. Whereas gain of 8q24-qter was observed in 82.6% (19 of 23) of stage III and IV cancers, it was seen in 27.3% (3 of 11) of stage I tumors. It is suggested that gain of 8q24-qter plays an important role in tumor progression. Gains of 8q24-qter and 20q12-qter and loss of 11q22-23 were linked to nodal metastasis (P = 0.0006, 0.002, and 0.02, respectively). Gains of 5p15 and 14q21 were associated with distant organ metastasis after surgery (P = 0.006 and 0.02, respectively). These observations suggest that nodal and distant organ metastases involve different genes. Gains of 5p15, 8q24-qter, and 14q21 were significantly associated with unfavorable prognosis (P = 0.0002, 0.007, and 0.04, respectively). Multivariate analysis revealed the 5p15 gain to be an independent prognostic marker with a higher significance than that of nodal status (risk ratio = 5.95; P = 0.001). The present findings indicate that comparative genomic hybridization analysis may be used to predict the likelihood of a poor or favorable outcome in cases of ESCC.
(キーワード): Aged / Aged, 80 and over / Carcinoma, Squamous Cell / Chromosome Mapping / Chromosomes, Human, Pair 5 / Esophageal Neoplasms / Female / Gene Dosage / Humans / Lymphatic Metastasis / Male / Middle Aged / Nucleic Acid Hybridization / Prognosis / Risk Factors / Time Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11839673; ● Search Scopus @ Elsevier (PMID): 11839673

(PubMed: 11839673) 高野尚史, 斎藤研一, 丹黒章, 岡正朗 :
脳転移を伴うStage IV進行乳癌に対する局所療法,
癌と化学療法, Vol.28, No.11, 1783-1786, 2001年.

(要約): A 55-year-old female patient was diagnosed with right breast cancer with brain metastasis of 3 cm in size. Neurological examination revealed paralysis in the left upper and lower extremities. Chemotherapy and hormone therapy were performed. Brachytherapy by Cyberknife was performed for the brain metastatic lesion. As a result, the brain metastatic lesion decreased in size to 1 cm on the CT-scan after 2 months. The paralysis disappeared and the patient's QOL improved. Cyberknife therapy was useful for a brain metastatic lesion that harmed the patient's QOL.
(キーワード): Antineoplastic Combined Chemotherapy Protocols / Brain Neoplasms / Breast Neoplasms / Carcinoma, Ductal, Breast / Female / Humans / Lymphatic Metastasis / Middle Aged / Paclitaxel / Quality of Life / Radiosurgery / Tamoxifen / Taxoids
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11708034; ● Search Scopus @ Elsevier (PMID): 11708034

(PubMed: 11708034) 前田義隆, M Nishida, N Mori, T Tamesa, T Okada, 丹黒章, M Oka :
肝細胞癌と胆管細胞癌の混合型,
日本臨牀, Vol.59 Suppl 6, 401-405, 2001年.

(キーワード): Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Carcinoma, Hepatocellular / Cholangiocarcinoma / Diagnosis, Differential / Hepatectomy / Humans / Liver Neoplasms / Lymph Node Excision / Neoplasms, Multiple Primary / Prognosis / Survival Rate
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11761981; ● Search Scopus @ Elsevier (PMID): 11761981

(PubMed: 11761981) M Ariga, K Suga, N Matsunaga, K Sasai, K Shimizu, Y Ishikawa, Akira Tangoku and R Eto :
Failure to detect a huge Meckel's diverticulum with abundant ectopic gastric mucosa on gastric mucosal scintigraphy with Tc-99m pertechnetate.,
Clinical Nuclear Medicine, Vol.26, No.5, 470-471, 2001.

(キーワード): Adult / Choristoma / Female / Gastric Mucosa / Humans / Meckel Diverticulum / Radiopharmaceuticals / Sodium Pertechnetate Tc 99m
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11317040; ● Search Scopus @ Elsevier (PMID): 11317040

(PubMed: 11317040) T Abe, M Oka, Akira Tangoku, H Hayashi, K Yamamoto, N Yahara, K Morita, T Tabata and Y Ohmoto :
Interleukin-6 production in lung tissue after transthoracic esophagectomy.,
Journal of the American College of Surgeons, Vol.192, No.3, 322-329, 2001.

(要約): The mechanisms of the reported high increase in interleukin-6 (IL-6) levels after esophagectomy are unclear. We investigated the influence of an intrathoracic procedure, esophagectomy, on IL-6 production in lung tissue.
(キーワード): Aged / 分散分析 (analysis of variance) / Biopsy / Bronchi / Carcinoma, Squamous Cell / Enzyme-Linked Immunosorbent Assay / Esophageal Neoplasms / Esophagectomy / Female / Humans / 免疫組織化学 (immunohistochemistry) / Interleukin-6 / Lung / Male / Middle Aged / Pulmonary Alveoli / RNA, Messenger / Respiratory Mucosa / Time Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11245374; ● Search Scopus @ Elsevier (PMID): 11245374

(PubMed: 11245374) N lizuka, K Miyamoto, Akira Tangoku, H Hayashi, S Hazama, S Yoshino, K Yoshimura, K Hirose, H Yoshida and M Oka :
Downregulation of intracellular nm23-H1 prevents cisplatin-induced DNA damage in oesophageal cancer cells: possible association with Na(+), K(+)-ATPase.,
British Journal of Cancer, Vol.83, No.9, 1209-1215, 2000.

(要約): Previously, we showed that expression of nm23-H1 is associated inversely with sensitivity to cisplatin in human oesophageal squamous cell carcinoma (OSCC). The present study was undertaken to investigate the association of nm23-H1 expression with cisplatin-induced DNA damage in OSCC using antisense nm23-H1 transfectants. YES-2/AS-12, an antisense nm23-H1-transfected OSCC cell line, showed significantly reduced expression of intracellular nm23-H1 protein compared with that in parental YES-2 cells and YES-2/Neo transfectants. Surface expression of nm23-H1 protein was not observed in any of the three cell lines. PCR analysis for DNA damage demonstrated that YES-2/AS-12 cells were more resistant to nuclear and mitochondrial DNA damage by cisplatin than were YES-2/Neo cells. In addition, mitochondrial membrane potentials and DNA fragmentation assays confirmed that YES-2/AS-12 was more resistant than YES-2/Neo to apoptosis induced by cisplatin. In contrast, YES-2/AS-12 was more sensitive to ouabain, a selective inhibitor of Na(+), K(+)-ATPase, than YES-2 and YES-2/Neo. Pre-treatment with ouabain resulted in no differences in cisplatin sensitivity between the three cell lines examined. Intracellular platinum level in YES-2/AS-12 was significantly lower than that in YES-2 and YES-2/Neo following incubation with cisplatin, whereas ouabain pre-treatment resulted in no differences in intracellular platinum accumulations between the three cell lines. Our data support the conclusion that reduced expression of intracellular nm23-H1 in OSCC cells is associated with cisplatin resistance via the prevention of both nuclear and mitochondrial DNA damage and suggest that it may be related to Na(+), K(+)-ATPase activity, which is responsible for intracellular cisplatin accumulation.
(キーワード): Antineoplastic Agents / アポトーシス (apoptosis) / 細胞分裂 (cell division) / Cisplatin / DNA (DNA) / DNA Damage / DNA Fragmentation / DNA, Antisense / DNA, Mitochondrial / Dose-Response Relationship, Drug / Down-Regulation / Drug Resistance, Neoplasm / Enzyme Inhibitors / Esophageal Neoplasms / Humans / Monomeric GTP-Binding Proteins / NM23 Nucleoside Diphosphate Kinases / Nucleoside-Diphosphate Kinase / Ouabain / Sodium-Potassium-Exchanging ATPase / Transcription Factors / Transfection / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1054/bjoc.2000.1436
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11027435; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033760343

(DOI: 10.1054/bjoc.2000.1436, PubMed: 11027435, Elsevier: Scopus) S Yoshino, T Tabata, S Hazama, N Iizuka, K Yamamoto, M Hirayama, Akira Tangoku and M Oka :
Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers.,
Anticancer Research, Vol.20, No.6C, 4707-4711, 2000.

(要約): Recent studies demonstrated that patients with advanced cancer may have impaired cell-mediated immunity caused by an imbalance between Th1 and Th2 responses. We evaluated the ability of lentinan (LNT) to modulate Th1 and Th2 responses in patients with digestive cancers.
(キーワード): Adjuvants, Immunologic / Adult / Aged / Aged, 80 and over / Antineoplastic Agents / CD4-Positive T-Lymphocytes / 細胞質分裂 (cytokinesis) / Digestive System Neoplasms / Female / Flow Cytometry / Humans / Immunity, Cellular / Interferon-gamma / Interleukin-4 / Lentinan / Male / Middle Aged / Prognosis / Regression Analysis / Survival Rate / Th1 Cells / Th2 Cells
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11205205; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034491571

(PubMed: 11205205, Elsevier: Scopus) 高尾貴史, 西田峰勝, 前田義隆, 森尚秀, 為佐卓夫, 丹黒章, 岡正朗 :
び慢性肺転移および残肝多発転移を伴う巨大肝細胞癌症例に対する減量手術としての下大静脈合併拡大肝右葉切除術,
癌と化学療法, Vol.27, No.12, 1947-1950, 2000年.

(要約): Continuous systemic infusion of low-dose cisplatin (CDDP) (10 mg/body/day) and 5-fluorouracil (5-FU) (500 mg/body/day) was performed for advanced hepatocellular carcinoma (HCC) after hepatectomy with diffuse lung metastases and multiple intrahepatic metastases. This infusion chemotherapy, cisplatin was continued for five days, and discontinued for two days, whereas 5-fluorouracil was administered every day and repeated four weeks as one course basally. Remnant metastases had almost disappeared after systemic chemotherapy for 10 weeks. In our experience, the response rate in 13 patients who underwent reduction surgery for multiple HCC was 84.6%. Continuous infusion of low-dose CDDP/5-FU may be effective in patients having absolute non-curative resection.
(キーワード): Adult / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Hepatocellular / Cisplatin / Combined Modality Therapy / Drug Administration Schedule / Female / Fluorouracil / Hepatectomy / Humans / Liver Neoplasms / Lung Neoplasms / Neoplasm Recurrence, Local / Prognosis / Vena Cava, Inferior
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11086451; ● Search Scopus @ Elsevier (PMID): 11086451

(PubMed: 11086451) 前田義隆, 西田峰勝, 高尾貴史, 森尚秀, 為佐卓夫, 前田祥成, 丹黒章, 岡正朗, 白沢宏幸 :
門脈内(Vp2)および下大静脈内腫よう栓(Vv3)と肺転移を伴った肝細胞癌に対し外科切除と化学療法を施行した1例,
癌と化学療法, Vol.27, No.12, 1951-1954, 2000年.

(要約): A 39-year-old woman was admitted to our hospital because of advanced hepatocellular carcinoma. She had good liver function with clinical Stage I. Abdominal ultrasonographic study and CT scan revealed a huge tumor of 12 cm in diameter in the left lobe of the liver, with tumor thrombi in the portal and hepatic veins. A chest CT scan demonstrated multiple bilateral lung metastases from 5 to 10 mm in size. An extended left hemihepatectomy with extirpation of the portal and hepatic venous tumor thrombi was performed. On postoperative day 7, low-dose cisplatin (10 mg/day-5 days/week) and 5-fluorouracil (250 mg/day-continuous for 7 days/week) were administered intravenously. Four weeks after chemotherapy, CT scan revealed no recurrence in the liver and no change in the lung metastases. The patient is now being treated on an outpatient basis with no change in the metastatic tumors.
(キーワード): Adult / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Hepatocellular / Cisplatin / Combined Modality Therapy / Drug Administration Schedule / Female / Fluorouracil / Hepatic Veins / Humans / Liver Neoplasms / Lung Neoplasms / Neoplastic Cells, Circulating / 門脈 (portal vein)
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11086452; ● Search Scopus @ Elsevier (PMID): 11086452

(PubMed: 11086452) N Mori, M Oka, S Hazama, N Iizuka, K Yamamoto, S Yoshino, Akira Tangoku, Takafumi Noma and K Hirose :
Detection of telomerase activity in peritoneal lavage fluid from patients with gastric cancer using immunomagnetic beads,
British Journal of Cancer, Vol.83, No.8, 1026-1032, 2000.

(要約): Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from patients with gastric cancer. In the first part, 12 lavage-fluid samples obtained from 12 patients with gastric cancer were analysed using the conventional telomeric repeat amplification protocol (TRAP) assay. Three of five patients with early gastric cancer had positive telomerase activity. These false-positive results may have been due to lymphocyte contamination. Furthermore, polymerase chain reaction inhibitors were also detected in the lavage-fluid samples. Therefore, we developed a novel method for elimination of haematopoietic cell and Taq polymerase inhibitors to increase the accuracy of the TRAP assay using immunomagnetic beads, which bind to most normal and neoplastic human epithelial cells. Telomerase activity was found in 10 of 20 (50%) lavage-fluid samples from patients with serosal or subserosal invasion. Cytologic examination was positive in nine of 20 (45%) samples. Both the telomerase activity and cytology were negative in all 14 patients without serosal or subserosal invasion. These results suggest that the TRAP assay combined with immunomagnetic beads might be useful for detection of free cancer cells in the peritoneal space in gastric cancer without the aid of an experienced cytologist.
(キーワード): Adenocarcinoma / Adult / Aged / Ascitic Fluid / False Positive Reactions / 女性 (female) / Humans / Immunomagnetic Separation / 男性 (male) / Middle Aged / Peritoneal Lavage / Polymerase Chain Reaction / Reproducibility of Results / Stomach Neoplasms / Telomerase / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1054/bjoc.2000.1408
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10993650; ● Summary page in Scopus @ Elsevier: 2-s2.0-0033774144

(DOI: 10.1054/bjoc.2000.1408, PubMed: 10993650, Elsevier: Scopus) N Iizuka, K Miyamoto, S Hazama, S Yoshino, K Yoshimura, K Okita, T Fukumoto, S Yamamoto, Akira Tangoku and M Oka :
Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6.,
Cancer Letters, Vol.158, No.1, 35-41, 2000.

(要約): Herbs as alternative cancer therapies have attracted a great deal of recent attention due to their low toxicity and costs. In this study, the antitumor activity and anticachectic effect of Coptidis rhizoma, an anti-inflammatory herb, were investigated in nude mice carrying a human esophageal cancer cell line YES-2, which constitutively secretes interleukin-6 (IL-6) and induces cachexia when injected into these mice. In this study, in vivo growth of YES-2 cells was not affected by an oral supplement containing the extract powder of C. rhizoma at a final concentration of 1% (CR supplement). However, in comparison with normal diet, CR supplement significantly attenuated weight loss of tumor-bearing mice without a change in food or water intake. Tumor IL-6 levels were significantly lower in mice treated with CR supplement than in control mice (P<0.001). Serum IL-6 was detectable in four (50%) of eight control mice; IL-6 was not detected in mice treated with CR supplement. We also confirmed that berberine (8-32 microM), a major component of C. rhizoma, dose-dependently inhibited secretion of IL-6 by YES-2 cells in vitro. Moreover, reverse transcription-PCR assay showed that treatment of YES-2 cells with berberine (8-32 microM) for 24 h reduced IL-6 mRNA expression. Our results suggest that C. rhizoma may have an anticachectic effect on esophageal cancer and an effect is associated with the ability of berberine to down-regulate tumor IL-6 production.
(キーワード): Administration, Oral / Animals / Anti-Inflammatory Agents / Antineoplastic Agents, Phytogenic / Berberine / Cachexia / 細胞分裂 (cell division) / Disease Models, Animal / Down-Regulation / Drug Screening Assays, Antitumor / Esophageal Neoplasms / Interleukin-6 / Male / Mice / Mice, Inbred BALB C / Neoplasm Transplantation / Plant Extracts / Plants, Medicinal / Tumor Cells, Cultured
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10940506; ● Search Scopus @ Elsevier (PMID): 10940506

(PubMed: 10940506) 丹黒章, 林弘人, 吉野茂文, 安部俊弘, 多田耕輔, 森田克彦, 上野隆, 岡正朗 :
食道アカラシアにおける治療最近の動向 6．食道アカラシアに対するバルーン拡張術,
日本外科学会雑誌, Vol.101, No.4, 345-351, 2000年.

(要約): Esophageal dilation therapy for esophageal achalasia has a 300-year history and remains the first-line therapy because of its low cost, progressively decreasing morbidity and mortality, and possibility of surgery for patients who do not improve. Another advantage is the feasibility of repeated trial even after surgery. The aim of this procedure is to produce a controlled tear in the lower esophageal sphincter muscle. Precise esophagographic, endoscopic, and manometric diagnosis is necessary for successful esophageal dilation therapy. In addition, the exclusion of pseudoachalasia using echogram or CT scan is important. The procedure should be carried out accurately to prevent complications. If perforation occurs, appropriate, timely management is required.
(キーワード): Balloon Dilation / Esophageal Achalasia / Humans / Male / Middle Aged / Treatment Outcome
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10845197; ● Search Scopus @ Elsevier (PMID): 10845197

(PubMed: 10845197) Akira Tangoku, H Hayashi, S Kanamura, S Yoshino, T Abe, Y Yoshimoto, T Morioka and M Oka :
Lymph node metastases identified with mediastinoscopy in a patient with superficial carcinoma of the esophagus.,
Surgical Endoscopy, Vol.14, No.6, 595, 2000.

(要約): Superficial esophageal cancers limited to the lamina propria are not associated with lymph node metastases. Mediastinoscopic transhiatal esophagectomy was planned in a patient with widespread superficial cancer of the midthoracic esophagus. Sampling of the upper mediastinal lymph nodes revealed metastases. The operation was converted to a transthoracic esophagectomy with radical lymphadenectomy. Histopathologic examination of the resection specimen showed three metastatic lymph nodes, despite local invasion limited to the lamina propria. This is the first report of a patient with superficial esophageal cancer and lymph node metastases.
(キーワード): Carcinoma, Squamous Cell / Esophageal Neoplasms / Female / Humans / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Mediastinoscopy / Middle Aged / Neoplasm Invasiveness
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s004640001026
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11265071; ● Search Scopus @ Elsevier (PMID): 11265071; ● Search Scopus @ Elsevier (DOI): 10.1007/s004640001026

(DOI: 10.1007/s004640001026, PubMed: 11265071) K Tada, M Oka, H Hayashi, Akira Tangoku, A Oga and K Sasaki :
Cytogenetic analysis of esophageal squamous cell carcinoma cell lines by comparative genomic hybridization: relationship of cytogenetic aberrations to in vitro cell growth.,
Cancer Genetics and Cytogenetics, Vol.117, No.2, 108-112, 2000.

(要約): Cancer is characterized by autonomous growth of cells, and it is widely accepted that cell proliferation is primarily influenced by individual cell genetics. To elucidate the mechanisms of cancer cell proliferation, we studied differences in genetic aberrations for different type of tumors with different proliferation characteristics. We employed comparative genomic hybridization (CGH) to detect genetic aberrations in six cell lines of esophageal squamous cell carcinoma (ESCC). Three cell lines (YES-1, -2, and -3) grow in culture without fetal calf serum (group A), while others require serum to be maintained in vitro (group B). Both groups showed very similar cytogenetic aberrations: over-representations of 11q13 (6/6), 8q23-qter (5/6), Xq25-qter (5/6), 3q26-qter (4/6), 5p (4/6), 7p15-pter (4/6), 8q21.3-q22 (4/6), 17p (4/6), and 20q13 (4/6), and under-representations of 18q21-qter (6/6), 4q28-q33 (4/6), and 9p21 (4/6). Six amplification loci were mapped to chromosomal regions of 6q23 (1 case), 7p12 (2 cases), 9p21 (1 case), 11p11.2-12 (3 cases), 11q13 (2 cases), and 17p12 (2 cases). However, some differences were detected. DNA copy number increases at 7p12-p13, 11q14-q22, and 11q22-qter and under-representations of 4p, 8p, and 11p14-pter. In contrast, gains at 12p and 20p, and losses at 3p and 5q were detected only in group-B cell lines. These observations suggest that cytogenetic differences between the two groups may be linked to differences in cell growth characteristics in vitro, and that the genes in these chromosomal regions may play important roles in cell proliferation.
(キーワード): Carcinoma, Squamous Cell / 細胞分裂 (cell division) / Chromosome Aberrations / DNA, Neoplasm / Esophageal Neoplasms / Humans / Nucleic Acid Hybridization / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0165-4608(99)00160-0
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10704679; ● Search Scopus @ Elsevier (PMID): 10704679; ● Search Scopus @ Elsevier (DOI): 10.1016/S0165-4608(99)00160-0

(DOI: 10.1016/S0165-4608(99)00160-0, PubMed: 10704679) K Tada, M Oka, Akira Tangoku, H Hayashi, A Oga and K Sasaki :
Gains of 8q23-qter and 20q and loss of 11q22-qter in esophageal squamous cell carcinoma associated with lymph node metastasis.,
Cancer, Vol.88, No.2, 268-273, 2000.

(要約): Esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis and lymph node metastasis is one of the critical prognostic factors. Although it is important to elucidate the genetic aberrations underlying its lymph node metastasis, to the authors' knowledge little is known regarding alterations in the primary ESCC that are linked with ESCC metastasis to the lymph nodes.
(キーワード): Carcinoma, Squamous Cell / Chromosome Aberrations / Chromosomes, Human, Pair 11 / Chromosomes, Human, Pair 22 / DNA, Neoplasm / Esophageal Neoplasms / Female / Gene Amplification / Humans / Lymphatic Metastasis / Male / Nucleic Acid Hybridization / Prognosis
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10640956; ● Search Scopus @ Elsevier (PMID): 10640956

(PubMed: 10640956) N Iizuka, K Miyamoto, K Okita, Akira Tangoku, H Hayashi, S Yosino, T Abe, T Morioka, S Hazama and M Oka :
Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines.,
Cancer Letters, Vol.148, No.1, 19-25, 2000.

(要約): Our previous study demonstrated that the herbal medicine, Oren-to, had antitumor effects on esophageal cancer cells (ECCs) in vitro. The purpose of this study was to examine which of the seven constituents of Oren-to had antitumor effects on esophageal cancer cells. MTT assay showed that, of the seven constituents, only the aqueous extract of Coptidis Rhizoma had potent inhibitory effect on the proliferation of two types of ECC lines, YES-3 and YES-4. In addition, the proliferation of all six types of ECC lines (YES-1 to YES-6) was inhibited in a dose-dependent manner (P<0.001 for all), when co-cultured at each concentration of Coptidis Rhizoma for 72 h. The ID50 of Coptidis Rhizoma for YES-1 to YES-6 was 2.2 microg/ml, 3.0 microg/ml, 0.25 microg/ml, 2.8 microg/ml, 2.5 microg/ml, and 0.5 microg/ml, respectively, berberine, one of protoberberine components of Coptidis Rhizoma, showed potent antitumor effects on all six types of ECC lines as well as Coptidis Rhizoma. In addition, the ID50 of berberine showed a positive correlation with that of Coptidis Rhizoma in six types of ECC lines examined (r2 = 0.763, P = 0.023). Cell cycle analysis of Coptidis Rhizoma-treated cancer cells showed the accumulation of cells in the G0/G1 phase and relative decrease of the S phase. These results support the possibility that the use of Coptidis Rhizoma containing abundant berberine may be useful as one of alternative therapies for esophageal cancers.
(キーワード): Antineoplastic Agents / Berberine / 細胞周期 (cell cycle) / 細胞分裂 (cell division) / Dose-Response Relationship, Drug / Drug Screening Assays, Antitumor / Drugs, Chinese Herbal / Esophageal Neoplasms / Flow Cytometry / Formazans / Humans / Tetrazolium Salts / Tumor Cells, Cultured
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10680588; ● Search Scopus @ Elsevier (PMID): 10680588

(PubMed: 10680588) T Abe, Akira Tangoku, H Hayashi, S Takeda, S Yoshino and M Oka :
Esophageal perforation and mediastinal abscess following placement of a covered self-expanding metallic stent and radiation therapy in a cancer patient.,
Surgical Endoscopy, Vol.13, No.10, 1044-1046, 1999.

(要約): Patients with advanced esophageal cancer may require intubation with a stent to relieve debilitating dysphagia. However, if these patients also undergo radiation therapy, they may incur esophageal injury, thus increasing the risk of perforation after placement of the stent. Herein we report the case of a 71-year-old man who received such combination therapy and died of severe sepsis 65 days after the stent was inserted. An autopsy revealed that the stent had perforated into the mediastinal pleura and that an abscess had developed around the perforation. We conclude that caution should be taken before combining radiation therapy with the use of a stent.
(キーワード): Abscess / Aged / Carcinoma, Squamous Cell / Esophageal Neoplasms / Esophageal Perforation / Fatal Outcome / Humans / Male / Mediastinal Diseases / Stents
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10526046; ● Search Scopus @ Elsevier (PMID): 10526046

(PubMed: 10526046) Akira Tangoku, K Yamamoto, K Hirazawa, T Takao, N Mori, K Tada and M Oka :
Laparoscopic resection of large leiomyomas of the gastric fundus.,
Surgical Endoscopy, Vol.13, No.10, 1050-1052, 1999.

(要約): Two patients with a large leiomyoma arising from the gastric fundus underwent laparoscopic resection. In case 1, the tumor was located in the anterior wall of the gastric fundus. To prevent stenosis and preserve the volume of the residual stomach, intragastric resection was adopted. The tumor was markedly and resected with laparosonic coagulating shears with a 1-cm safety margin. In case 2, a large tumor was detected in the duodenal bulb. Serious hemorrhage mandated emergency resection. The tumor originated from the posterior wall of the fundus. Attempts at reduction with the forceps failed. Reduction by digital manipulation via laparoscopic port sites was successful. An endostapler was used to resect the tumor and close the anterior wall. Both patients recovered uneventfully.
(キーワード): Aged / Female / Gastric Fundus / Humans / Laparoscopy / Leiomyoma / Magnetic Resonance Imaging / Male / Stomach Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10526048; ● Search Scopus @ Elsevier (PMID): 10526048

(PubMed: 10526048) 高尾貴史, 西田峰勝, 前田義隆, 森尚秀, 為佐卓夫, 丹黒章, 岡正朗 :
肝細胞癌に対するLow‐Dose CDDP+5‐FU肝動注療法の位置づけ,
癌と化学療法, Vol.26, No.12, 1836-1840, 1999年.

(要約): Seven patients with postoperative recurrence of hepatocellular carcinoma (HCC) and four patients who underwent absolute non curative resection for HCC were treated with continuous arterial infusion of low-dose cisplatin (CDDP) (10 mg/body/day) and 5-fluorouracil (5-FU) (250 mg/body/day). This infusion chemotherapy was continued for five days and discontinued for two days, repeated over four weeks as one course. The response rate in patients with postoperative recurrence was 42.9%, while that in patients who underwent reduction surgery for multiple HCC was 75%. Continuous arterial infusion of low-dose CDDP/5-FU may be effective in patients with multiple small intrahepatic metastases.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Hepatocellular / Cisplatin / Drug Administration Schedule / Female / Fluorouracil / Hepatic Artery / Humans / Infusion Pumps, Implantable / Infusions, Intra-Arterial / Liver Neoplasms / Male / Middle Aged
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10560407; ● Search Scopus @ Elsevier (PMID): 10560407

(PubMed: 10560407) 前田義隆, 西田峰勝, 高尾貴史, 原田菊夫, 森尚秀, 為佐卓夫, H Somura, 丹黒章, 岡正朗, 小西知己 :
Docetaxel肝動注が奏効した乳癌肝転移の1例,
癌と化学療法, Vol.26, No.12, 1951-1954, 1999年.

(要約): Docetaxel is an excellent agent with a high antitumor effect for the treatment of advanced/recurrent breast cancer. A 55-year-old female with metastatic liver tumors from breast cancer showed a remarkable response to intra-arterial administration of docetaxel (20 mg/week, or 40 mg/2 weeks). Since CT and MRI imaging revealed multiple metastases in the liver, intra-arterial chemotherapy was selected. No critical side effect was found during this chemotherapy. A CT scan 3 months after chemotherapy showed a partial response. We conclude that this intra-arterial chemotherapy using docetaxel will be safe and useful for liver metastases from breast cancer.
(キーワード): Adenocarcinoma, Scirrhous / Antineoplastic Agents, Phytogenic / Breast Neoplasms / Female / Hepatic Artery / Humans / Infusions, Intra-Arterial / Liver Neoplasms / Lymph Node Excision / Middle Aged / Paclitaxel / Taxoids
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10560434; ● Search Scopus @ Elsevier (PMID): 10560434

(PubMed: 10560434) N Iizuka, K Hirose, Takafumi Noma, S Hazama, Akira Tangoku, H Hayashi, T Abe, K Yamamoto and M Oka :
The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma,
British Journal of Cancer, Vol.81, No.3, 469-475, 1999.

(要約): Recently, nm23-H1, an anti-metastasis gene, has been reported to correlate with sensitivity to chemotherapeutic agents including cisplatin in human breast and ovarian carcinoma cells. The aim of this study was to evaluate a role for nm23-H1 in responsiveness to cisplatin-based chemotherapy in patients with oesophageal squamous cell carcinoma (OSCC). The expression of nm23-H1 protein was examined immunohistochemically in 32 eligible patients with OSCC who underwent adjuvant chemotherapy with cisplatin, etoposide, and 5-fluorouracil after tumour resection. Fifteen (46.9%) of 32 patients were positive for nm23-H1 staining and 17 (53.1%) were negative. Both disease-free survival and overall survival rates of nm23-H1-negative patients were significantly shorter than in nm23-H1-positive patients (P < 0.01 for both). There was no significant difference in clinicopathologic characteristics between nm23-H1-positive and nm23-H1-negative groups. Multivariate analysis also showed that nm23-H1 expression was the most significant factor for overall survival of OSCC patients included in this study (P = 0.0007). To further study the role of nm23-H1, a human OSCC cell line (YES-2) was transfected with a plasmid containing a fragment of the nm23-H1 cDNA in an antisense orientation. Reduced expression of nm23-H1 protein in the antisense-transfected (AS) clones was found by Western blot analysis as compared to wild-type YES-2 and YES-2/Neo (clone transfected with the neomycin resistance gene alone). MTT (3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H tetrazolium bromide) assay showed that reduced expression of the nm23-H1 protein in AS clones was consistent with the degree of increased resistance to cisplatin but not etoposide or 5-fluorouracil. These data support the conclusion that reduced expression of nm23-H1 may be associated with resistance to cisplatin, suggesting the value of nm23-H1 expression as a prognostic marker for OSCC patients who are to undergo cisplatin-based chemotherapy.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Chemotherapy, Adjuvant / Cisplatin / Combined Modality Therapy / DNA, Complementary / Disease-Free Survival / Drug Resistance, Neoplasm / Esophageal Neoplasms / Etoposide / Female / Fluorouracil / Humans / Male / Middle Aged / Monomeric GTP-Binding Proteins / NM23 Nucleoside Diphosphate Kinases / Neoplasm Proteins / Nucleoside-Diphosphate Kinase / Oligonucleotides, Antisense / Survival Analysis / Survival Rate / Transcription Factors / Transfection / Treatment Outcome / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/sj.bjc.6690717
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10507772; ● Summary page in Scopus @ Elsevier: 2-s2.0-0032883690

(DOI: 10.1038/sj.bjc.6690717, PubMed: 10507772, Elsevier: Scopus) Akira Tangoku, H Hayashi, S Yoshino, T Ueno, T Abe, Y Yoshimoto, T Morioka and M Oka :
Wire-guided transoral esophagogastrostomy for carcinoma of the cervical esophagus.,
Journal of the American College of Surgeons, Vol.189, No.3, 330-333, 1999.

(キーワード): Anastomosis, Surgical / Esophageal Neoplasms / Esophagostomy / Gastrostomy / Humans / Mouth / Neck / Surgical Staplers
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10472936; ● Search Scopus @ Elsevier (PMID): 10472936

(PubMed: 10472936) N Iizuka, S Hazama, K Hirose, T Abe, N Tokuda, T Fukumoto, Akira Tangoku and M Oka :
Interleukin-1 receptor antagonist mRNA expression and the progression of gastric carcinoma.,
Cancer Letters, Vol.142, No.2, 179-184, 1999.

(要約): Interleukin-1 receptor antagonist (IL-1ra), an endogeneous inhibitor of IL-1, plays an immunosuppressive role in vivo by blocking the proinflammatory effects of IL-1. In the present study, we examined whether IL-1ra expression in human gastric carcinoma correlates with tumor progression and/or metastatic potential. The reverse transcription-polymerase chain reaction was used to compare the expression of the secreted form of IL-1ra (sIL-1ra) and the intracellular form of IL-1ra (icIL-1ra) mRNA in tumor and corresponding benign tissue obtained from 38 patients with gastric carcinoma. The incidence of sIL-1ra mRNA expression was significantly higher in tumor (52%) than in corresponding benign tissue (18%) (P = 0.002). On the contrary, icIL-1ra mRNA was detected in all tumors and benign tissues. The expression of sIL-1ra mRNA by malignant tissue correlated positively with both lymph node metastasis (P = 0.008) and liver metastasis (P = 0.015). There was no association between tumor sIL-lra mRNA expression and other clinicopathologic factors. The degree of regional lymph node reaction, such as sinus histiocytosis, in tumors expressing sI-1ra mRNA was significantly weaker than that in tumors without sIL-1ra mRNA expression (5/20 vs. 12/18, P = 0.010). These results demonstrate that the altered expression of sIL-1ra by malignant tissue may be related to the progression of gastric carcinoma via modulating host immune response.
(キーワード): Adult / Aged / Female / Humans / Interleukin 1 Receptor Antagonist Protein / Liver Neoplasms / Lymphatic Metastasis / Male / Middle Aged / RNA, Messenger / Receptors, Interleukin-1 / Reverse Transcriptase Polymerase Chain Reaction / Sialoglycoproteins / Stomach Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10463774; ● Search Scopus @ Elsevier (PMID): 10463774

(PubMed: 10463774) Y Masaki, M Oka, Y Ogura, T Ueno, K Nishihara, Akira Tangoku, M Takahashi, M Yamamoto and T Irimura :
Sialylated MUC1 mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma.,
Hepato-Gastroenterology, Vol.46, No.28, 2240-2245, 1999.

(要約): Pancreatic cancer has the poorest prognosis of all gastrointestinal cancers. Because sialylated mucin influences the biologic behavior of carcinoma cells, we investigated sialylated MUC1 mucin expression in patients with pancreatic ductal adenocarcinoma.
(キーワード): Adenocarcinoma / Adult / Aged / Aged, 80 and over / Cell Membrane / Cystadenoma, Mucinous / Female / Humans / Hyperplasia / Immunohistochemistry / Male / Middle Aged / Mucin-1 / Pancreas / Pancreatic Diseases / Pancreatic Ducts / Pancreatic Neoplasms / Pancreatitis / Sialic Acids / Tumor Markers, Biological
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10521973; ● Search Scopus @ Elsevier (PMID): 10521973

(PubMed: 10521973) M Oka, S Hazama, M Takahashi, K Yamamoto, T Abe, S Yoshino, H Hayashi and Akira Tangoku :
Relationship between serum levels of soluble interleukin-2 receptor and various disease parameters in patients with squamous cell carcinoma of the esophagus.,
Hepato-Gastroenterology, Vol.46, No.28, 2254-2259, 1999.

(要約): Soluble interleukin-2 receptor (sIL-2R) is a useful biomarker for the management of hematologic malignancies. We determined the significance of serum sIL-2R levels in patients with squamous cell carcinoma of the esophagus.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma, Squamous Cell / Esophageal Neoplasms / Female / Humans / Immunohistochemistry / Lymphatic Metastasis / Male / Middle Aged / Receptors, Interleukin-2 / Tumor Markers, Biological
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10521976; ● Search Scopus @ Elsevier (PMID): 10521976

(PubMed: 10521976) 石津和彦, 白石晃司, 河村英文, 内藤克輔, 高橋徹, 吉村清, 丹黒章, 白浜秀也 :
RET遺伝子変異による多発性内分泌腫よう症 2A型(MEN2A)の1例,
泌尿器科紀要, Vol.45, No.6, 407-410, 1999年.

(要約): A 44-year-old woman complained of headache and palpitation. Magnetic resonance imaging showed bilateral adrenal tumors 10 x 9 cm in size on the left side and 8 x 4 cm in size on the right side. CT scan revealed a 0.7 x 0.7 cm mass in the thyroid. Hormonal examinations showed high values of urinary cathecholamines and serum calcitonin. DNA sequence analysis of peripheral white blood cells revealed that codon 634 in exon 11 of the RET gene was mutated from TGC (Cys) to TAC (Tyr). From these findings, a diagnosis was made of MEN2A with bilateral adrenal pheochromocytomas and medullary thyroid carcinoma. Bilateral adrenalectomy and thyroidectomy were performed. The same mutation of the RET gene was detected in all her 3 children, in two of whom, early stage medullary thyroid carcinoma was detected and thyroidectomy was performed. DNA analysis of the RET gene was useful for the diagnosis of carriers of MEN2A and the early detection of medullary thyroid carcinoma.
(キーワード): Adolescent / Adrenal Gland Neoplasms / Adrenalectomy / Adult / Carcinoma, Medullary / Drosophila Proteins / Female / Heterozygote / Humans / Male / Multiple Endocrine Neoplasia Type 2a / Mutation / Pheochromocytoma / Proto-Oncogene Proteins / Proto-Oncogene Proteins c-ret / Receptor Protein-Tyrosine Kinases / Thyroid Neoplasms / Thyroidectomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10442282; ● Search Scopus @ Elsevier (PMID): 10442282

(PubMed: 10442282) M Oka, Y Yoshimoto, T Ueno, K Yoshimura, Y Maeda and Akira Tangoku :
Treatment of cholecystoduodenal fistula by laparoscopy.,
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, Vol.9, No.3, 213-216, 1999.

(要約): We describe a patient with cholecystoduodenal fistula treated by a laparoscopic approach. Use of a flexible videoscope, flexible retractor, and endoscopic transecting stapler allows for laparoscopic treatment of cholecystoenteric fistulae.
(キーワード): Biliary Fistula / Duodenal Diseases / Female / Gallbladder Diseases / Humans / Intestinal Fistula / Laparoscopy / Middle Aged
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10804004; ● Search Scopus @ Elsevier (PMID): 10804004

(PubMed: 10804004) K Suga, K Miura, N Kume, A Hara, N Matsunaga, Akira Tangoku and M Oka :
Tc-99m colloid and Ga-67 imaging of splenic inflammatory pseudotumor correlation with ultrasound, CT, and MRI.,
Clinical Nuclear Medicine, Vol.24, No.5, 334-337, 1999.

(要約): Splenic inflammatory pseudotumor is extremely rare and may mimic splenic neoplasms, such as lymphomas or hamartomas, clinically and radiologically. A case of a surgically proved splenic inflammatory pseudotumor is presented in which Tc-99m colloid SPECT and Ga-67 scintigraphy characterized the changes in the spleen, but the findings of ultrasound and unenhanced CT and MRI were nonspecific. This report indicates the utility of radionuclide imaging for diagnosing splenic inflammatory pseudotumor.
(キーワード): Gallium Radioisotopes / Granuloma, Plasma Cell / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Middle Aged / Organotechnetium Compounds / Phytic Acid / Radiopharmaceuticals / Splenic Diseases / Tomography, Emission-Computed, Single-Photon / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10232472; ● Search Scopus @ Elsevier (PMID): 10232472

(PubMed: 10232472) N Iizuka, Akira Tangoku, H Hayashi, S Yosino, T Abe, T Morioka and M Oka :
The association between nm23-H1 expression and survival in patients with esophageal squamous cell carcinoma.,
Cancer Letters, Vol.138, No.1-2, 139-144, 1999.

(要約): The nm23 gene is a potential metastasis suppressor gene originally identified using a murine melanoma cell line. The expression of nm23-H1 protein was examined immunohistochemically in 50 eligible patients with esophageal squamous cell carcinoma (ESCC). The expression was not correlated with other prognostic factors including lymph node metastases; however, overall survival rates of nm23-H1-negative patients were significantly shorter than those of nm23-H1-positive patients (P < 0.05). Furthermore, reduced expression of nm23-H1 was associated with shorter overall survival in patients with involved lymph nodes (P < 0.01), but not in patients without involved lymph nodes. These data support the conclusion that reduced expression of nm23-H1 may be associated with poor prognosis of ESCC patients, suggesting the value of nm23-H1 expression as a prognostic marker for ESCC patients, especially ESCC patients with involved lymph nodes.
(キーワード): Adult / Aged / Carcinoma, Squamous Cell / Esophageal Neoplasms / Female / Humans / Immunohistochemistry / Male / Middle Aged / Monomeric GTP-Binding Proteins / NM23 Nucleoside Diphosphate Kinases / Nucleoside-Diphosphate Kinase / Prognosis / Survival Rate / Transcription Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10378785; ● Search Scopus @ Elsevier (PMID): 10378785

(PubMed: 10378785) T Takao, M Nishida, Y Maeda, S Hiraki, K Takao, Akira Tangoku and M Oka :
Effect of cautery with irrigation forceps on the remnant liver after hepatectomy in rats.,
European Surgical Research, Vol.31, No.2, 173-179, 1999.

(要約): Monopolar cautery with irrigation forceps (CIF) was devised for use in liver resection that does not require occlusion of inflow to the remnant liver. However, a high power output is required to divide the hepatic parenchyma which boils the irrigation water. This study was performed to investigate the effects of using CIF on the hepatic parenchyma. Histologic and biochemical examination was performed in rats which had undergone hepatectomy using the CIF, irrigating bipolar (IB), Pringle's maneuver with blunt dissection (group P), or a sham operation. A greater cautery distance was obtained with the CIF than the IB. There was no significant difference in the remnant liver function after the 1st postoperative day in any of the groups. CIF is an effective instrument for anatomic or nonanatomic hepatic resection.
(キーワード): Animals / Cautery / Hepatectomy / Laparotomy / Liver / Male / Rats / Surgical Instruments / Therapeutic Irrigation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10213856; ● Search Scopus @ Elsevier (PMID): 10213856

(PubMed: 10213856) 西田峰勝, 前田義隆, 高尾康一郎, 原田菊夫, 衛藤隆一, 丹黒章, 岡正朗 :
局所療法としてのVp3肝癌に対する腫よう栓摘出術,
癌と化学療法, Vol.25, No.9, 1374-1377, 1998年.

(要約): Portal thrombectomy with extended hepatectomy for extensively progressive primary liver cancer (Vp 3), in which the tumor thrombus has spread beyond the first portal branches, will make other non-surgical treatments possible and improve patients quality of life. We have performed extensive resections in 15 cases of such Vp 3 liver cancer. One patient with huge HCC involving retrohepatic IVC underwent in situ extended left hepatectomy without reconstruction of IVC, resulting in postoperative renal failure because of thrombosis in the bilateral renal veins, but 14 other patients' postoperative courses were uneventful. Ten of 14 patients relapsed within one year, but these patients underwent non-surgical treatments, resulting in improvement in the quality of life. The 1-, and 3-year survival rates were 55.6% and 32.5%, respectively.
(キーワード): Adult / Aged / Carcinoma, Hepatocellular / Hepatectomy / Humans / Liver Neoplasms / Male / Middle Aged / Neoplastic Cells, Circulating / 門脈 (portal vein) / Survival Rate
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9703832; ● Search Scopus @ Elsevier (PMID): 9703832

(PubMed: 9703832) M Oka, K Yamamoto, M Nakamura, M Miyahara, T Ueno, K Nishihara and Akira Tangoku :
Reconstruction after proximal gastrectomy using a stapled, U-shaped jejunal pouch.,
Journal of the American College of Surgeons, Vol.186, No.5, 601-603, 1998.

(キーワード): Anastomosis, Surgical / Esophagus / Gastrectomy / Humans / Jejunum / Reconstructive Surgical Procedures / Stomach Neoplasms / Surgical Staplers / Surgical Stapling / Suture Techniques / Transplantation, Autologous
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9583704; ● Search Scopus @ Elsevier (PMID): 9583704

(PubMed: 9583704) M Nakamura, Akira Tangoku, H Kusanagi, M Oka and T Suzuki :
Breast cancer associated with Recklinghausen's disease: report of a case.,
Archiv für Japanische Chirurgie, Vol.67, No.1, 3-9, 1998.

(要約): A 49-year-old woman with Recklinghausen's disease presented to our department for investigation of a left breast lump, measuring 60 mm x 50 mm, which she had first noticed 6 months earlier, but had disregarded, believing it to be another manifestation of her Recklinghausen's disease. The lump was suspected to be malignant based on physical examination and ultrasonography. Biopsy and frozen sections subsequently confirmed a diagnosis of scirrhous carcinoma. A standard radical mastectomy was performed, followed by postoperative chemoendocrine therapy. However, lungs, liver, and bone metastasis, as well as a contralateral breast tumor, developed and she died 4 months after surgery.
(キーワード): Adenocarcinoma, Scirrhous / Breast Neoplasms / Female / Humans / Middle Aged / Neurofibromatosis 1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10401230; ● Search Scopus @ Elsevier (PMID): 10401230

(PubMed: 10401230) M Nakamura, Akira Tangoku, M Oka and T Suzuki :
A case of invasive lobular carcinoma of the breast.,
The Kurume Medical Journal, Vol.45, No.1, 147-150, 1998.

(要約): A 43-year-old woman presented to our department with left breast lump, measuring 10 mm x 10mm x 6mm. On physical examination and mammography, the lump was suspected to be due to mastopathy, but malignancy could not be excluded based on ultrasonography. Excisional biopsy showed that it was an invasive lobular carcinoma. A modified radical mastectomy was performed after obtaining informed consent. She remained disease-free seven years after surgery.
(キーワード): Adult / Breast Neoplasms / Carcinoma, Lobular / Female / Humans / Neoplasm Invasiveness
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9658766; ● Search Scopus @ Elsevier (PMID): 9658766

(PubMed: 9658766) K Yamamoto, M Oka, H Hayashi, Akira Tangoku, T Gondo and T Suzuki :
CYFRA 21-1 is a useful marker for esophageal squamous cell carcinoma.,
Cancer, Vol.79, No.9, 1647-1655, 1997.

(要約): CYFRA 21-1 measures soluble cytokeratin-19 fragments in serum and is a useful marker for lung carcinoma, especially squamous cell carcinoma (SCC). The authors conducted this study to determine the significance of CYFRA 21-1 in patients with esophageal SCC.
(キーワード): Adult / Aged / Aged, 80 and over / Antigens, Neoplasm / Carcinoembryonic Antigen / Carcinoma, Squamous Cell / Esophageal Neoplasms / Female / Humans / Immunohistochemistry / Keratins / Male / Middle Aged / Serpins / Tumor Cells, Cultured / Tumor Markers, Biological
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9128978; ● Search Scopus @ Elsevier (PMID): 9128978

(PubMed: 9128978) K Suga, K Nishigauchi, K Shimizu, N Kume, N Matsunaga, Y Sato, Akira Tangoku, N Kouichi and K Esato :
SPECT with In-111 autologous platelets to detect residual splenic tissue in two patients with relapsed thrombocytopenia.,
Clinical Nuclear Medicine, Vol.22, No.3, 141-146, 1997.

(要約): In two patients with relapsed thrombocytopenia, the authors used SPECT with In-111 labeled autologous platelets to identify residual splenic tissue after splenectomy. One case involved a previously splenectomized patient with idiopathic portal hypertension, while the other had relapsed chronic idiopathic thrombocytopenic purpura (ITP). In both patients, SPECT showed a higher In-111 uptake in the splenic tissues compared with planar images. In the patient with ITP, a small accessory spleen had been overlooked on abdominal CT because of post-operative changes, but it was identified by superimposition of SPECT/CT images. These cases indicate that In-111 platelet SPECT is useful in detecting and localizing residual accessory splenic tissue associated with relapsed thrombocytopenia.
(キーワード): Adult / Aged / Blood Platelets / Humans / Indium Radioisotopes / Male / Purpura, Thrombocytopenic, Idiopathic / Recurrence / Spleen / Splenectomy / Thrombocytopenia / Tomography, Emission-Computed, Single-Photon / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9067665; ● Search Scopus @ Elsevier (PMID): 9067665

(PubMed: 9067665) F Numa, H Ogata, Y Suminami, N Tsunaga, Y Nakamura, H Tamura, N Takasugi, H Kato, Akira Tangoku, T Uchiyama, M Oka, T Suzuki, M Yamamoto and K Naito :
Pelvic exenteration for the treatment of gynecological malignancies.,
Archives of Gynecology and Obstetrics, Vol.259, No.3, 133-138, 1997.

(要約): Twenty-three patients undergoing pelvic exenteration for primary and recurrent gynecological malignancies from 1976 to 1994 are reported. Fifteen patients underwent total pelvic exenteration, 3 underwent anterior exenteration, and 5 underwent a posterior procedure. Eight patients had exenteration as their primary treatment (primary group), and 15 underwent exenteration as secondary treatment (recurrent group). In the primary group, two patients developed recurrence and died of it at 6 and 20 months after operation. Five patients are still being followed up and are alive without disease. Four of these 5 patients have survived more than 5 years. In the recurrent group, 12 patients were followed up and three died of complications during the early years. Seven patients died of cancer with the mean survival time of 16.6 months. The mean age, average operating time, and mean blood loss in the primary and recurrent groups were 57 vs. 53 years, 8 hours and 20 min vs. 8 hours and 10 min, and 4,120 vs. 4,190 ml, respectively. The overall cumulative 5-year survival rate was 34.7%, being 68.6% in the primary group and 16.7% in the recurrent group. It is noteworthy that the 5-year survival rate was 51.3% in the patients who had surgical margins free of disease. In conclusion, pelvic exenteration should be considered an acceptable therapeutic option when appropriately selected.
(キーワード): Adult / Aged / Blood Loss, Surgical / Female / Genital Neoplasms, Female / Humans / Middle Aged / Neoplasm Staging / Pelvic Exenteration / Postoperative Complications / 生活の質 (quality of life) / Recurrence / Survival Rate / Time Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9187465; ● Search Scopus @ Elsevier (PMID): 9187465

(PubMed: 9187465) M Oka, K Yamamoto, M Takahashi, M Hakozaki, T Abe, N Iizuka, S Hazama, K Hirazawa, H Hayashi, Akira Tangoku, K Hirose, T Ishihara and T Suzuki :
Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma.,
Cancer Research, Vol.56, No.12, 2776-2780, 1996.

(要約): Serum levels of interleukin 6 (IL-6) are correlated with the disease status and prognosis in cancer patients. IL-6 is also an important mediator of experimental cancer cachexia. We investigated the production of IL-6 and IL-6 receptors and expression of IL-6 mRNA by esophageal squamous carcinoma cells using immunohistochemical staining and in situ reverse transcription-PCR. We also measured levels of serum IL-6 using an ELISA in 50 patients with esophageal squamous cell carcinoma (ESCC) to determine the correlation between serum levels of IL-6 and clinicopathological factors IL-6 mRNA was expressed in the primary tumor. Esophageal squamous carcinoma cells produced both IL-6 and IL-6 receptor. IL-6 concentrations were significantly higher in the primary tumor than in the normal epithelium. The incidences of weight loss, tumor invasion to adjacent organs, and noncurative resection were significantly higher in ESCC patients with serum levels of IL-6 > or = 7 pg/ml (n = 13, group C) compared with patients with serum levels <7 pg/ml and > or = 3 pg/ml (n = 14, group B) and <3 pg/ml (n = 23, group A). Tumor size and C-reactive protein levels were significantly higher and albumin levels were significantly lower in group C. Results suggest that IL-6, which is produced by tumor cells, may be related to various disease parameters as well as to the nutritional status in patients with ESCC.
(キーワード): Adult / Aged / Aged, 80 and over / Antigens, CD / Base Sequence / Carcinoma, Squamous Cell / Esophageal Neoplasms / Female / Humans / Interleukin-6 / Male / Middle Aged / Molecular Sequence Data / Neoplasm Proteins / Nutrition Disorders / RNA, Messenger / Receptors, Interleukin / Receptors, Interleukin-6 / Tumor Markers, Biological
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8665513; ● Search Scopus @ Elsevier (PMID): 8665513

(PubMed: 8665513) P Chowdhury, R Doi, Akira Tangoku and P L. Rayford :
Structural and functional changes of rat exocrine pancreas exposed to nicotine.,
The International Journal of Pancreatology, Vol.18, No.3, 257-264, 1995.

(要約): Nicotine, an addictive agent in cigarette smoking, has been implicated in the etiology of pancreatitis and pancreatic carcinoma. Very little experimental data are, however, available regarding the effects of nicotine on the structural and functional changes in the exocrine pancreas. Two groups of rats divided into control and nicotine exposed were used. The animals in the nicotine group were maintained for 28 d with ad libitum water containing 0.77 mM of nicotine. At term, the animals were sacrificed, and pancreas was examined for pathological and functional changes. Nicotine induced cytoplasmic vacuolation and cellular edema in the exocrine pancreas. Plasma levels of glucose and insulin and CCK-8-stimulated amylase release in isolated acini were significantly decreased by nicotine, whereas the total cellular amylase content was significantly increased. Analysis of competitive ligand binding data on membranes from isolated acini showed that the Bmax and Kd values for CCK receptors were not significantly changed by nicotine, p > 0.05. These data indicate that a postreceptor mechanism is involved in the inhibition in stimulus-secretion coupling of enzyme secretion by nicotine. The increase in total cellular amylase content and decreased enzyme secretion by nicotine may be implicated in the induction of pancreatic pathology.
(キーワード): Amylases / Animals / Male / Nicotine / Pancreas / Rats / Rats, Sprague-Dawley / Receptors, Cholecystokinin
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/BF02784950
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8708398; ● Search Scopus @ Elsevier (PMID): 8708398; ● Search Scopus @ Elsevier (DOI): 10.1007/BF02784950

(DOI: 10.1007/BF02784950, PubMed: 8708398) 和田守憲二, 岡正朗, 清水良一, 丹黒章, 硲章一, 柳生岳志, 鈴木敬, 波多野仁子, F Kurokawa, K Okita :
癌局所療法研究会回腸カルチノイドの肝多発転移巣にソマトスタチン誘導体の持続肝動注が有効であった1例,
癌と化学療法, Vol.22, No.11, 1669-1672, 1995年.

(要約): We report a case of multiple liver metastasis from ileac carcinoid treated with continuous intraarterial infusion of somatostatin analog. A 65-year-old man who complained of chest pain was admitted to Yamaguchi University Hospital School of Medicine for further examination of cardiac angina. Liver tumors, which were detected during ECHO cardiogram examination, were diagnosed as metastasis from carcinoid by percutaneous transhepatic liver biopsy. Primary tumor was found at the ileum by colonofiberscopy. We performed ileo-cecal resection and catheterization from the gastroduodenal artery for intraarterial chemotherapy under laparotomy. After the operation, the patient was treated with continuous intraarterial infusion of somatostatin analog (100 micrograms/day, 5 days/week for 16 weeks). The tumor in segment 6 (S6) disappeared, but the tumor in S2 enlarged after the therapy. Hepatic angiography confirming the drug distribution demonstrated the occlusion of the left hepatic artery. This drug was thus distributed to the tumor in S6 but not in S2. These results suggest that somatostatin analog may have a direct anti-tumor effect. Furthermore, no side effect was observed. Thus, intraarterial infusion of somatostatin analog may be a useful therapy for liver metastasis from carcinoid.
(キーワード): Aged / Antineoplastic Agents, Hormonal / Carcinoid Tumor / Combined Modality Therapy / Drug Administration Schedule / Hepatic Artery / Humans / Ileal Neoplasms / Infusion Pumps, Implantable / Infusions, Intra-Arterial / Liver Neoplasms / Male / Octreotide
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7574789; ● Search Scopus @ Elsevier (PMID): 7574789

(PubMed: 7574789) 鶴見征志, 岡正朗, 硲彰一, 丹黒章, 浜中裕一郎, 鈴木たかし :
肝動注5‐FU/MTX交代療法が有効であった胃癌肝転移の1例,
癌と化学療法, Vol.21, No.13, 2179-2182, 1994年.

(要約): A 75-year-old man with gastric cancer having multiple liver metastases was given intraarterial infusion therapy with sequential low-dose MTX (30 mg/body) and 5-FU (1,000 mg/body) for metastatic liver tumors one month after the primary gastric tumor was resected. This therapy was given once a week on admission and every two weeks while an outpatient. A total of 18 courses of this therapy produced marked regression and necrosis of liver metastases. The effect was thus rated as partial response. This patient survived 15 months after surgery. These results indicate that intraarterial infusion therapy with sequential low-dose MTX and 5-FU may be effective in multiple liver metastasis from gastric cancer.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Drug Administration Schedule / Fluorouracil / Humans / Infusion Pumps, Implantable / Infusions, Intra-Arterial / Leucovorin / Liver Neoplasms / Male / Methotrexate / Stomach Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7944434; ● Search Scopus @ Elsevier (PMID): 7944434

(PubMed: 7944434) M Nishikawa, Akira Tangoku, Y Hamanaka, T Suzuki and P L. Rayford :
Gastric pH monitoring after pylorus preserving pancreaticoduodenectomy with Billroth I type of reconstruction.,
Journal of the American College of Surgeons, Vol.179, No.2, 129-134, 1994.

(要約): A late complication of pancreaticoduodenectomy is anastomotic ulcer, and the complication is lessened when pancreaticoduodenectomy is accompanied by preservation of the pylorus. However, the results of some reports suggest that acid levels are not significantly different between patients who undergo pylorus preserving pancreaticoduodenectomy (PPPD) and those having standard pancreaticoduodenectomy. In this study, we measured gastric acidity in the same patients both before and after PPPD.
(キーワード): Adult / Aged / Anastomosis, Surgical / Eating / Fasting / Female / Gastric Acid / Humans / Hydrogen-Ion Concentration / Jejunum / Male / Middle Aged / Monitoring, Physiologic / Pancreaticoduodenectomy / Posture / Pylorus / Sleep / Stomach / Time Factors
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7913855; ● Search Scopus @ Elsevier (PMID): 7913855

(PubMed: 7913855) M Nishikawa, T Murakami, Akira Tangoku, H Hayashi, J Adachi and T Suzuki :
Functioning of the intrathoracic stomach after esophagectomy.,
Archives of Surgery, Vol.129, No.8, 837-841, 1994.

(要約): To investigate acid secretion and motility of the intrathoracic stomach with truncal vagotomy after esophagectomy.
(キーワード): Case-Control Studies / Digestive System / Esophageal Neoplasms / Esophagectomy / Female / Gastric Acid / Gastric Emptying / Gastrointestinal Motility / Humans / Hydrogen-Ion Concentration / Male / Middle Aged / Stomach / Vagotomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8048854; ● Search Scopus @ Elsevier (PMID): 8048854

(PubMed: 8048854) Akira Tangoku, R Doi, P Chowdhury, G T. Blevins, J N. Pasley and P L. Rayford :
Exogenous administration of estradiol and cholecystokinin alters exocrine pancreatic function in rats.,
The International Journal of Pancreatology, Vol.13, No.2, 81-86, 1993.

(要約): This study was conducted in rats to investigate the influence of exogenously administered estradiol (ESD) and/or cholecystokinin (CCK) on components and secretions of the pancreatic acini. Intact male rats were treated for 14 d with exogenous administration of ESD, CCK, or ESD+CCK. After 14 d CCK treatment induced significant increases in DNA and RNA contents, and DNA/RNA ratio in the pancreas, indicating hyperplasia and hypertrophy of the pancreas, however, ESD treatment did not have these effects. Both ESD treatment and CCK treatment induced significant increases in amylase and trypsinogen contents in pancreatic acini and each decreased secretion from acini in response to CCK. Combined treatment with ESD plus CCK augmented these effects on enzyme contents and secretion. The results indicate that exogenous administration of CCK has trophic effects on the exocrine pancreas, increasing effects on enzyme contents and inhibitory effects on amylase secretion. In contrast, exogenous administration of ESD had no trophic effects on pancreas, but had increasing effects on enzyme contents and inhibitory effects on amylase secretion. The results suggest that the effects of exogenous ESD and CCK on pancreas are not similar to each other, but both ESD and CCK may be involved in regulating pancreatic exocrine functions.
(キーワード): Amylases / Animals / Body Weight / Cholecystokinin / Estradiol / Male / Pancreas / Rats / Rats, Sprague-Dawley / Reference Values
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/BF02786075
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7684759; ● Search Scopus @ Elsevier (PMID): 7684759; ● Search Scopus @ Elsevier (DOI): 10.1007/BF02786075

(DOI: 10.1007/BF02786075, PubMed: 7684759) Akira Tangoku, R Doi, P Chowdhury, G T. Blevins, J N. Pasley, L W. Chang and P L. Rayford :
Humoral factors that induce alterations of the pancreas in rats with obstructive jaundice.,
Pancreas, Vol.8, No.1, 103-108, 1993.

(要約): This study was conducted to investigate the role of humoral factors in pancreatic alterations induced by obstructive jaundice (OJ) in rats. OJ in male Sprague-Dawley rats induced significant increases in pancreatic weight, DNA content, and RNA content of acinar cells. These changes were accompanied by enlargement of eosinophilic granules and compressed nuclei. Protein, amylase, and trypsinogen contents of pancreas were also increased in OJ rats. In addition, plasma levels of bilirubin, cholecystokinin (CCK), and estradiol increased in OJ rats and were correlated positively with each other and with pancreatic weights. Administration of a specific CCK receptor, L-364,718, to OJ rats partly attenuated the changes of the pancreas, indicating that CCK is involved in these changes. These findings suggest that estradiol may be involved in regulating the pancreatic changes induced by OJ in rats.
(キーワード): Amylases / Animals / Cholecystokinin / Cholestasis / Estradiol / Male / Pancreas / Proteins / Rats / Rats, Sprague-Dawley / Trypsinogen
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7678321; ● Search Scopus @ Elsevier (PMID): 7678321

(PubMed: 7678321) Y Sato, H Tominaga, Akira Tangoku, Y Hamanaka, Y Yamashita and T Suzuki :
Alpha-fetoprotein-producing cancer of the ampulla of Vater.,
Hepato-Gastroenterology, Vol.39, No.6, 566-569, 1992.

(要約): A case of cancer of the ampulla of Vater producing alpha-fetoprotein is reported and the literature is reviewed. As far as we know, the literature contains no reports of such a case. The preoperative serum alpha-fetoprotein was remarkably high (7,480 ng/ml), but it fell to normal values (under 5.0 ng/ml) after pancreatoduodenectomy, by means of which the lesion could be radically resected. In this case, the immunohistochemical findings at optical and electron microscopy clearly indicated the production of alpha-fetoprotein by the cancer cells of the ampulla of Vater.
(キーワード): Adenocarcinoma / Aged / Ampulla of Vater / Common Bile Duct Neoplasms / Humans / Male / Pancreaticoduodenectomy / alpha-Fetoproteins
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1282896; ● Search Scopus @ Elsevier (PMID): 1282896

(PubMed: 1282896) Akira Tangoku, P Chowdhury, Y S. Huang, R Doi, G T. Blevins, C Eyiuche, D W. McKay and P L. Rayford :
Exocrine pancreatic function in obstructive jaundice rats: studies with isolated dispersed pancreatic acini.,
The Journal of Surgical Research, Vol.53, No.4, 378-383, 1992.

(要約): This study was conducted to investigate pancreatic exocrine function and pancreatic growth in rats with obstructive jaundice (OJ). OJ was produced in adult male Sprague-Dawley rats by bile duct ligation; control rats underwent laparotomy only. Induction of OJ was associated with significant hyperplasia and hypertrophy of the pancreas in rats as shown by increased DNA and RNA contents of pancreatic tissue. Factors associated with pancreatic growth in OJ rats were further examined in isolated dispersed pancreatic acini from OJ rats and the data were compared with those for control rats. Studies with isolated dispersed acini from OJ rats showed that pancreatic growth was accompanied by significant increases in total cellular amylase content; however, amylase release (percentage of initial) in response to cholecystokinin octapeptide was significantly decreased in OJ rats compared to control rats. Total amylase output in response to 100 pM cholecystokinin (CCK) was higher in the OJ group when compared to the control group (8.6 U/mg protein versus 6.4 U/mg protein), as calculated from the total amylase content and percentage of amylase released. Receptor binding data showed that the capacity of CCK receptors in OJ rats was significantly lower when it was compared with control. In addition, plasma levels of CCK were significantly elevated in OJ rats when compared to controls. These results suggest that obstructive jaundice induces pancreatic growth that is associated with alteration of exocrine pancreatic function. Abnormally high levels of stored amylase in pancreatic acini may be implicated in the development of pancreatitis as often seen in obstructive jaundice patients.
(キーワード): Amylases / Animals / Bile Ducts / Bilirubin / Cholestasis / DNA (DNA) / Hyperplasia / Hypertrophy / Ligation / Male / Pancreas / RNA (RNA) / Rats / Rats, Sprague-Dawley / Sincalide
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1383615; ● Search Scopus @ Elsevier (PMID): 1383615

(PubMed: 1383615) G T. Blevins, R Doi, Akira Tangoku, P Chowdhury, D McKay and P L. Rayford :
Simultaneous measurement of cholecystokinin-stimulated amylase release and cholecystokinin receptor binding in rat pancreatic acini.,
The Journal of Laboratory and Clinical Medicine, Vol.119, No.5, 566-573, 1992.

(要約): In the past, isolated-dispersed pancreatic acini have been used to examine either cholecystokinin-stimulated amylase release or pancreatic acinar cholecystokinin receptors. We have developed and validated a method for simultaneous measurement of synthetic cholecystokinin octapeptide-stimulated (CCK8-stimulated) pancreatic amylase release and cholecystokinin receptors. After an 18-hour fast, rats were killed and their pancreatic acini isolated. Three-milliliter aliquots of acinar suspension were incubated for 60 minutes in N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid-Ringer buffer containing graded doses of CCK8 and a constant amount (7 pmol/L) of iodine 125-labeled CCK8 (by the Bolton-Hunter method) ([125I]BH-CCK8). A 1 ml sample was removed from each flask for determination of amylase release, and the remaining 2 ml were used to determine cholecystokinin receptor capacities and affinities. The median effective dose for amylase release was 16 pmol/L, and release was maximal at 100 pmol/L CCK8 plus 7 pmol/L [125I]BH-CCK8, a dose that released 28% +/- 3% of total cellular amylase content. High affinity (equilibrium dissociation constant of high-affinity receptors = 58 +/- 8 pmol/L, receptor density of high-affinity receptors = 4 +/- 1 fmol/mg protein) and low affinity (equilibrium dissociation constant of low-affinity receptors = 7 +/- 2 nmol/L, receptor density of low-affinity receptors = 313 +/- 108 fmol/mg protein) cholecystokinin receptors were measured. The results demonstrate that CCK8-stimulated amylase release and cholecystokinin receptor binding in pancreatic acini can be measured concurrently and that the parameters of amylase release and cholecystokinin receptor binding are strikingly similar to those previously observed.(ABSTRACT TRUNCATED AT 250 WORDS)
(キーワード): Amylases / Animals / Cholecystokinin / Pancreas / Rats / Receptors, Cholecystokinin
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1374786; ● Search Scopus @ Elsevier (PMID): 1374786

(PubMed: 1374786) R Doi, Akira Tangoku, K Inoue, P Chowdhury and P L. Rayford :
Effects of FK506 on exocrine pancreas in rats.,
Pancreas, Vol.7, No.2, 197-204, 1992.

(要約): The efficacy of FK506 on exocrine pancreas was studied in rats. Male Sprague-Dawley rats (230-250 g) received an i.m. daily injection of FK506 (0.1, 0.5, or 5.0 mg/kg), cyclosporine (CS; 25 mg/kg), or saline for 2 weeks. Isolated dispersed pancreatic acini were prepared from rats, and enzyme content of the cells and secretory response to cholecystokinin (CCK) were determined. Amylase and trypsin contents were increased in a dose-related manner by FK506 (p less than 0.01) and by CS at 25 mg/kg (p less than 0.01). The release of amylase in response to CCK was reduced by FK506 in a dose-related manner (p less than 0.01) and by CS at 25 mg/kg (p less than 0.01). Histologic examination showed that treatment of rats with FK506 at 0.1 mg/kg did not affect morphology of the acinar cells. FK506 at 0.5 mg/kg induced a minimal number of small vacuoles in cytoplasm of acinar cells and FK506 at 5.0 mg/kg, and CS at 25 mg/kg induced numerous cytoplasmic vacuoles and pyknotic nuclei. Increased enzyme storage and suppressed responsiveness of amylase release may have an association with the histologic changes. Therefore, the results of this study suggest that FK506, even when used in a low dose, may have adverse effects on the exocrine pancreas. Understanding of the mechanism of action of FK506 on pancreas will provide essential basic information that will allow transplant practitioners to more fully explore the benefits of this drug.
(キーワード): Amylases / Animals / Male / Organ Size / Pancreas / Rats / Rats, Inbred Strains / Tacrolimus
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1372739; ● Search Scopus @ Elsevier (PMID): 1372739

(PubMed: 1372739) Akira Tangoku, R Doi, P Chowdhury, J N. Pasley, D W. McKay and P L. Rayford :
Use of a specific cholecystokinin receptor antagonist (L-364,718) to determine the role of cholecystokinin on feeding and body weight in rats with obstructive jaundice.,
Journal of the Association for Academic Minority Physicians, Vol.3, No.2, 38-40, 1992.

(要約): We conducted a study to examine the role of cholecystokinin in feeding behavior and weight change in rats with obstructive jaundice. Daily food and water intake, body weight, and short-term food intake were determined in two groups of rats with surgically induced obstructive jaundice and in control rats. One group of rats with obstructive jaundice was given L-364,718, a selective cholecystokinin receptor antagonist. Plasma bilirubin and cholecystokinin levels were measured in each rat before and 7 days after surgery. Daily food intake and body weight were decreased in obstructive jaundice rats compared with control rats during the first week after surgery (P less than .05); however, obstructive jaundice rats treated with L-364,718 had increased food intake and body weight (P less than .05). Short-term food intake measured for 30 minutes and 120 minutes in food-deprived obstructive jaundice rats was decreased when compared with control rats (P less than .05), but the obstructive jaundice rats given L-364,718 had increased short-term food intake (P less than .05). Water intake was similar between the two groups of rats. Plasma levels of cholecystokinin and bilirubin were increased in obstructive jaundice rats with and without L-364,718 treatment (P less than .05). The results support the concept that endogenously elevated levels of plasma cholecystokinin play an important role in decreased food intake and subsequent loss of body weight in rats with obstructive jaundice.
(キーワード): Animals / Benzodiazepinones / Bilirubin / Body Weight / Cholecystokinin / Cholestasis / Devazepide / Feeding Behavior / Male / Rats / Rats, Inbred Strains
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1576458; ● Search Scopus @ Elsevier (PMID): 1576458

(PubMed: 1576458) R Doi, Akira Tangoku, K Inoue, P Chowdhury and P L. Rayford :
Mechanisms by which FK 506 affects exocrine pancreas in rats.,
Transplantation Proceedings, Vol.23, No.6, 3161-3163, 1991.

(キーワード): Amylases / 分散分析 (analysis of variance) / Animals / Dose-Response Relationship, Drug / Kinetics / Male / Pancreas / Rats / Rats, Inbred Strains / Reference Values / Tacrolimus
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1721392; ● Search Scopus @ Elsevier (PMID): 1721392

(PubMed: 1721392) Akira Tangoku, M Nishikawa, A Adachi and T Suzuki :
Plasma gastrin and cholecystokinin response after pylorus-preserving pancreatoduodenectomy with Billroth-I type of reconstruction.,
Annals of Surgery, Vol.214, No.1, 56-60, 1991.

(要約): Plasma gastrin and cholecystokinin (CCK) responses were measured after a pancreatoduodenectomy (PD) using the Billroth-I type reconstruction combined with distal partial gastrectomy (standard PD) and combined with preservation of the pylorus and the duodenal bulb (PPPD). Six unoperated patients, 4 men and 2 women, were studied as control subjects. Basal plasma levels of gastrin were significantly higher in controls than in patients who had a standard PD (p less than 0.05) and gastrin responses to a meal were also blunted in these patients. In contrast basal and postprandial levels of gastrin after PPPD were significantly higher than these found in patients with standard PD (p less than 0.05). Postprandial gastrin response after PPPD were similar in pattern to these found in controls. Integrated gastrin release after PPPD was less than that of the control but was significantly greater than that in patients with standard PD. Basal plasma levels of CCK in the patients after the standard PD were significantly lower than in controls and significantly higher postprandial levels of CCK were found after PPPD compared to standard PD (p less than 0.05). However integrated CCK from 0 to 120 minutes were not significantly different between PPPD and standard PD groups. Based on these observations concerning hormonal release of gastrin and CCK, preservation of the stomach and the duodenal bulb appears to be a more physiologic reconstructive procedure than the standard PD. In addition the operation probably has more beneficial effect on the injured pancreas in time.
(キーワード): Adolescent / Adult / Aged / Cholecystokinin / Eating / Female / Follow-Up Studies / Gastrectomy / Gastrins / Humans / Male / Middle Aged / Pancreatic Diseases / Pancreaticojejunostomy / Postoperative Period / Pylorus / Radioimmunoassay / Radionuclide Imaging
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2064472; ● Search Scopus @ Elsevier (PMID): 2064472

(PubMed: 2064472) G T. Blevins, H S. Huang, Akira Tangoku, D W. Mckay and P L. Rayford :
Estrogens influence cholecystokinin stimulated pancreatic amylase release and acinar cell membrane cholecystokinin receptors in rat.,
Life Sciences, Vol.48, No.16, 1565-1574, 1991.

(要約): This study examines the influence of ovariectomy and administration of a pharmacologic dose of estradiol on amylase release from isolated-dispersed rat pancreatic acini and cholecystokinin receptors on rat acinar cell membranes. Rats were sham ovariectomized (intact) or ovariectomized (Ovx) and 21 day timed release pellets containing either estradiol (2.5 mg) or vehicle, were implanted subcutaneously. Eighteen days later, pancreatic acini were isolated from rats by collagenase digestion and differential centrifugation. Total cellular amylase, basal and cholecystokinin octapeptide (CCK8) stimulated amylase release and CCK membrane receptors were measured. Acini isolated from estradiol treated Ovx rats had significantly greater total cellular amylase, compared to acini isolated from either intact or Ovx rats. The amplitude of both total stimulated amylase release and percent total stimulated amylase release were significantly greater for acini isolated from vehicle treated Ovx rats, than acini isolated from either intact or estradiol treated Ovx rats. The magnitude of percent total amylase release of acini isolated from estradiol treated Ovx rats was significantly lower than that of acini isolated from intact rats. Cholecystokinin receptor concentration was significantly greater on membranes prepared from vehicle treated Ovx rats, compared to membranes prepared from either intact or estradiol treated Ovx rats. These data indicate that ovariectomy is associated with increased responsiveness of pancreatic acini to CCK stimulation, while chronic estradiol treatment of ovariectomized rats is associated with increased total cellular amylase and decreased acinar cell responsiveness to CCK8. Estrogen mediated alterations in acinar cell amylase content and amylase release may play a role in estrogen related pancreatitis.
(キーワード): Amylases / Animals / Estradiol / Female / Male / Ovariectomy / Pancreas / Rats / Rats, Inbred Strains / Receptors, Cholecystokinin
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1708070; ● Search Scopus @ Elsevier (PMID): 1708070

(PubMed: 1708070) 丹黒章 :
噴門括約機構におけるVIPの関与と食道アカラシアの病態生理,
日本外科寶函, Vol.55, No.1, 81-95, 1986年.

(キーワード): Adult / Animals / Cardia / Dogs / Esophageal Achalasia / Esophagogastric Junction / Humans / Male / Secretin / Vasoactive Intestinal Peptide
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3741046; ● Search Scopus @ Elsevier (PMID): 3741046

(PubMed: 3741046) 石上浩一, 山時おさむ, 村上卓夫, 岡崎好夫, 岡正朗, 浜中裕一郎, 丹黒章 :
食道アカラシアおよび滑脱型食道裂孔ヘルニアと消化管ホルモンその外科的意義,
日本外科学会雑誌, Vol.86, No.9, 1153-1156, 1985年.

(要約): Experimental achalasia dogs produced with Deloyer's method showed higher resting pressure at the gastroesophageal junction and the increase in LES pressure in response to tetragastrin and cholecystokinin. Dose-response curve of the LES to each dose of tetragastrin in achalasia dog shifted to the left. Resting LES pressure in 11 patients with achalasia was 42.73 +/- 23.31 cm H2O. It increased significantly after intramuscular injection of 5 micrograms/kg of tetragastrin and fluoroscopic observation showed the tonic contraction of the lower esophagus and cardia. After the performance of Jekler-Lhotka operation, LES pressure decreased to lower values sufficient to prevent the gastroesophageal reflux. Comparing 5 kinds of hiatal herniorrhaphies in dogs, LES pressure increased postoperatively in the following order: Nissen, Belsey Mark IV, Stensrud, Hill and Harrington methods. Responses to tetragastrin increased after Nissen and Belsey Mark IV methods. In 12 out of 21 clinical cases of sliding esophageal hiatal hernia who had undergone Nissen-Rossetti method adding fundopexy and posterior gastropexy, preoperative esophageal manometry showed HPZ of 24.98 +/- 8.87 cm H2O in peak value and 5.1 +/- 3.46 cm in length. Seven cases showed the biphasic pattern and 5 cases showed the negative response to tetragastrin. Postoperative manometry showed HPZ of 31.42 +/- 18.46 cm H2O in peak value and 4.5 +/- 1.73 cm in length. One case showed the biphasic pattern and 3 cases showed the negative response to tetragastrin.
(キーワード): Animals / Dogs / Esophageal Achalasia / Gastrins / Gastrointestinal Hormones / Hernia, Diaphragmatic / Hernia, Hiatal / Humans
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 4088231; ● Search Scopus @ Elsevier (PMID): 4088231

(PubMed: 4088231)

MISC

石澤有紀, 坂東良美, 住谷さつき, 丹黒章, 葉久真理 :
研究に関する男女共同参画・ダイバーシティの推進状況に関するアンケート調査-全国の集計結果との比較から見える徳島大学の現状-,
徳島大学人と地域共創センター紀要, Vol.31, 17-32, 2022年.

(要約): 本調査では，全国ダイバーシティネットワークの幹事機関である大阪大学と，日本学術会議科学者委員会男女共同参画分科会・同アンケート検討小分科会が共同で実施した「大学・研究機関における男女共同参画・ダイバーシティの推進状況調査」のうち「大学・研究機関における男女共同参画の推進状況に対する意見・感想」について，徳島大学回答分(男性60 件，女性21 件)のみ抽出されたデータを用いて，本学における男女共同参画・ダイバーシティ推進に関する研究者の意識調査を実施した．男女別に集計し，公開されている全国集計結果(計10，105 件)と比較検討することで，全国における本学の位置付けについて分析した．調査項目は， 1 ．男女共同参画の推進(全般) 2 ．男女共同参画の取り組み 3 ．ワークライフバランス・育児支援サービス 4 ．ダイバーシティ対応 5 ．ハラスメント防止体制 6 ．医学系の6 項目にわたる．全国と徳島での回答差，また男女間の回答差から，現在の徳島大学の研究者における男女共同参画に対する意識について考察する．
(キーワード): ダイバーシティ推進 / 男女共同参画 / 女性研究者支援
(徳島大学機関リポジトリ): ● Metadata: 116860
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520010707343811712

(徳島大学機関リポジトリ: 116860, CiNii: 1520010707343811712) 吉田光輝, 先山正二, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
臨床と研究腎癌肺転移巣の組織学的異型度が画像診断に及ぼす影響,
胸部外科, Vol.66, No.11, 996-999, 2013年.

(キーワード): 肺転移 / 腎細胞癌 / 組織学的異型度 / lung metastasis / renal cell carcinoma / degree of histologic atypia
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24105116; ● CiNii @ 国立情報学研究所 (CRID): 1390282763058427648; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892415509

(PubMed: 24105116, CiNii: 1390282763058427648, Elsevier: Scopus) Akira Tangoku, Yota Yamamoto, Yoshihito Furukita, Hirokazu Takechi, Masakazu Goto, 西野豪志 and 坂本晋一 :
特集食道疾患手術のすべて Ⅱ．悪性疾患の手術 5．縦隔鏡補助下経裂孔的食道切除術,
Operation, Vol.67, No.10, 1435-1440, 2013.

(キーワード): 食道癌 / 縦隔鏡 / 非開胸食道抜去術 / 縦隔鏡下食道切除術
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1524232505259609728

(CiNii: 1524232505259609728) 武知浩和, 坂本晋一, 森下敦司, 後藤正和, 西野豪志, 古北由仁, 山本洋太, 吉田卓弘, 清家純一, 滝沢宏光, 丹黒章 :
食道癌頸部リンパ節再発による症状に対して緩和ケアを実践した2症例,
四国医学雑誌, Vol.69, No.3,4, 171-174, 2013年.

(要約): Our department aggressively performs initial treatment for esophageal carcinoma with multidisciplinary approaches, and not only positively treats patients with recurrence or metastasis but also manages those in an advanced stage by following the wishes of patients and their families as much as possible. However, many patients with esophageal carcinoma develop digestive tract and tracheal problems with progression of the disease, and the palliation of symptoms and continuation of home care often become difficult. In such patients, it is important to secure and maintain the route of hydration and nutrition when oral fluid and food intake becomes difficult, and to control respiratory symptoms for the promotion of home care and palliation of symptoms in the terminal stage. In this report, we present 2 patients managed by palliative care until death while supporting home care by maintaining enteral nutrition using gastrostomy for esophageal narrowing due to cervical lymph node recurrence, and controlling the cough reflex and dyspnea associated with the development of a cervical lymph node-tracheal fistula through morphine hydrochloride administration.
(キーワード): Palliative care / Home care / Esophageal carcinoma / Gastrostomy / Morphine
(徳島大学機関リポジトリ): ● Metadata: 109632
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050865122807795712

(徳島大学機関リポジトリ: 109632, CiNii: 1050865122807795712) 山本洋太, 丹黒章, 西野豪志, 後藤正和, 古北由仁, 武知浩和 :
【消化器外科看護まるわかりいちからわかる!術前術後ケア・解剖・疾患・治療】(第2章)消化器の解剖・疾患・術前術後ケア入門 <1-1>食道の解剖生理，疾患，検査・治療,
消化器外科Nursing, Vol.18, No.1, 138-150, 2013年. 丹黒章, 山本洋太, 古北由仁, 武知浩和, 後藤正和, 西野豪志, 森本雅美 :
Ⅰ食道の鏡視下手術縦隔鏡下食道切除術,
消化器外科, Vol.36, No.5, 539-546, 2013年. 丹黒章 :
わが国の乳癌検診のさらなる可能性を期待しながら,
日本乳癌検診学会誌, Vol.21, No.3, 219, 2012年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1570854176167292416

(CiNii: 1570854176167292416) 中川美砂子, Masami Morimoto, 丹黒章 :
[Oral chemotherapy for advanced breast cancer].,
日本臨牀, Vol.70, No.Suppl 7, 587-591, 2012年.

(キーワード): Administration, Oral / Antimetabolites, Antineoplastic / Breast Neoplasms / Deoxycytidine / Drug Combinations / Female / Fluorouracil / Humans / Molecular Targeted Therapy / Oxonic Acid / Tegafur
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23350468; ● Search Scopus @ Elsevier (PMID): 23350468

(PubMed: 23350468) 丹黒章 :
国際水準の乳がん検診を行うために,
日本乳癌検診学会誌, Vol.21, No.2, 113, 2012年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1573950400566859520

(CiNii: 1573950400566859520) 植野映, 丹黒章 :
総合討論,
日本乳癌検診学会誌, Vol.21, No.2, 143-145, 2012年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204465443584

(CiNii: 1390001204465443584) 丹黒章 :
Summing 「乳がんの予防」,
がん分子標的治療, Vol.3, No.4, 348-353, 2005年. 丹黒章 :
第13回日本乳癌学会総会印象記 ''民芸の町倉敷から最新治療コンセンサスを発信'',
乳癌の臨床, Vol.20, No.4, 297-300, 2005年. 長島由紀子, 丹黒章, 山本滋, 岡正朗, 菅一能 :
乳房温存療法における鏡視下郭清術,
手術, Vol.59, No.3, 359-363, 2005年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1521136280115837440

(CiNii: 1521136280115837440) 丹黒章, 中野基一郎, 山本滋 :
乳房温存療法における鏡視下腋窩郭清術,
からだの科学「増刊」高度先進医療, 147-150, 2005年. 丹黒章, 山本滋, 長島由紀子, 三瓶訓子, 岡正朗, 菅一能, 上田克彦 :
乳癌治療に対するアプローチ, --- センチネルリンパ節生検の現況と問題点 ---,
内分泌外科, Vol.21, No.4, 247-253, 2004年. 為佐卓夫, 渡邊裕策, 吉村清, 森尚秀, 山本滋, 硲彰一, 丹黒章, 岡正朗 :
二度の局所切除と全身化学療法にて5年生存を得ている大腸癌腹膜播腫の1切除例,
癌と化学療法, Vol.31, No.11, 1864-1866, 2004年.

(要約): A 66-year-old man underwent a curative operation for cecal cancer on the 30th of November, 1998. Since his CEA level rose in January 2001, computed tomography (CT) revealed a tumor in the abdomen. He underwent a resection of this tumor and disseminated tumors that were diagnosed during the operation. He received systemic chemotherapy (5'-DFUR 600 mg 3x everyday, CPT-11 80 mg/body div every 2 weeks), but the CEA level rose again in August 2003. He was diagnosed with spleen metastasis and underwent splenectomy. The tumor disseminated in the left diaphragm was also resected. After that, he received systemic chemotherapy (5-FU 500 mg/body/week div, levofolinate calcium 250 mg/body/week i.v.) as an outpatient. Peritoneal carcinomatosis from colorectal cancer with distant metastasis, in general, has no indication for an operation. However, if dissemination is located after a sufficient observation period, its resection may be recommended.
(キーワード): Adenocarcinoma / Aged / Antineoplastic Combined Chemotherapy Protocols / Camptothecin / Carcinoembryonic Antigen / Cecal Neoplasms / Combined Modality Therapy / Floxuridine / Fluorouracil / Humans / Leucovorin / Male / Neoplasm Seeding / Peritoneal Neoplasms / Reoperation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15553741; ● Search Scopus @ Elsevier (PMID): 15553741

(PubMed: 15553741) 森尚秀, 坂本和彦, 為佐卓夫, 岡田敏正, 竹本紀一, 橋本毅一郎, 丹黒章, 岡正朗 :
肝左葉切除後の上部消化管障害とその対策,
山口医学, Vol.53, No.3, 133-137, 2004年.

(キーワード): 肝左葉切除 / 上部消化管障害 / 術後合併症

丹黒章, 山本滋, 長島由紀子, 兼田健一郎, 亀井竜士, 渡邊裕策, 岡正朗, 菅一能, 上田克彦 :
乳癌手術におけるenbloc リンパ節郭清,
臨床外科, Vol.59, No.1, 13-18, 2004年.

(キーワード): Halsted 手術 / 乳房温存療法 / 腋窩郭清 / 内視鏡下手術

丹黒章, 山本滋, 長島由紀子, 緋田誠, 前田和成, 岡正朗 :
乳房温存療法における鏡視下郭清術,
手術, Vol.57, No.1, 31-37, 2003年.

総説・解説

丹黒章, 吉田卓弘, 武知浩和, 西野豪志, 古北由仁 :
食道胃接合部癌の姑息治療,
外科, Vol.77, No.4, 427-432, 2015年4月.

(キーワード): 食道胃接合部癌 / 姑息治療 / ステント / 緩和化学療法 / palliative chemotherapy
(出版サイトへのリンク): ● Publication site (DOI): 10.15106/j00393.2015188093
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390564238029328128; ● Search Scopus @ Elsevier (DOI): 10.15106/j00393.2015188093

(DOI: 10.15106/j00393.2015188093, CiNii: 1390564238029328128) 丹黒章 :
,,
今日の治療指針, 757, 2015年1月. 丹黒章, 吉田卓弘, 古北由仁, 西野豪志, 武知浩和 :
縦隔鏡下経裂孔的食道切除術,
手術, Vol.68, No.6, 827-834, 2014年6月. 丹黒章, 吉田卓弘, 西野豪志, 武知浩和, 古北由仁 :
経裂孔的食道切除術手術,
手術, Vol.68, No.4, 407-414, 2014年4月. 丹黒章 :
縦隔鏡下食道切除術,
手術, Vol.36, No.5, 539-546, 2013年5月.

(キーワード): 食道癌

丹黒章 :
- :,
2011年6月.

(キーワード): 乳癌

講演・発表

Makoto Funaki, Akiko Hata, Mitsuteru Yoshida, Naoki Miyamoto, Takahisa Ikuta, Yuta Uemura, Minato Akizuki, Akira Tangoku, Hiromichi Yumoto, Hirohisa Ogawa and Takeshi Oya :
Quiescence Recovers Adipose Tissue-Derived Stromal Cells from Senescence-Associated Secretory Phenotype, Leading to Enhanced Angiogenesis and Diabetic Wound Healing,
83nd Scientific Sessions presented by the American Diabetes Association, Jun. 2023. Makoto Funaki, Akiko Hata, Mitsuteru Yoshida, Naoki Miyamoto, Takahisa Ikuta, Yuta Uemura, MINATO AKIZUKI, Akira Tangoku, Hiromichi Yumoto, Hirohisa Ogawa and Takeshi Oya :
Quiescence Abrogates Stress-Induced Senescence-Associated Secretion Phenotype in Adipose-Derived Stem Cells and May Enhance Their Therapeutic Effects on Diabetic Complications,
Diabetes, Vol.71, No.Suppl_1, 305-OR, New Orleans, Jun. 2022.

(出版サイトへのリンク): ● Publication site (DOI): 10.2337/db22-305-OR
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2337/db22-305-OR

(DOI: 10.2337/db22-305-OR) Seiya Inoue, Takahiro Yoshida, Takeshi Nishino, Masakazu Goto and Akira Tangoku :
The sterno-tracheal distance is an important factor of anastomotic leakage of retrosternal gastric tube reconstruction after esophagectomy,
The International Society for Diseases of the Esophagus (Virtual), Sep. 2021.

(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-019-00705-9
(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-85075623295

(DOI: 10.1007/s10388-019-00705-9, Elsevier: Scopus) K. Muguruma, Kazuya Kondo, R. Kishibuchi, Mitsuhiro Tsuboi, S. Soejima, B. Tegshee, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
DNA Methylation of MT1A and NPTX2 Genes Predict Malignant Behavior of Thymic Epithelial Tumors,
The IASLC 20th World Conference on Lung Cancer, Sep. 2019. S. Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, R. Kishibuchi, K. Muguruma, B. Tegshee, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku and N. Wusiman :
GAD1 Expression and Its Methylation Become Indicators of Malignant Behavior in Thymic Epithelial Tumor,
The IASLC 20th World Conference on Lung Cancer, Sep. 2019. Hiromitsu Takizawa, Toru Sawada, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Autofluorescence Mode of Thoracoscope Improves Visceral Pleural Invasion Diagnosis in Non-Small Cell Lung Cancer,
19th World Conference on Lung Cancer, Sep. 2018. Naoya Kawakita, Hiromitsu Takizawa, Ali Eman, Mika Takashima, Daisuke Matsumoto, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Cone-Beam CT Confirms the Status of Transbronchial Biopsy Under Virtual Bronchoscopic Navigation for Peripheral Lung Lesions,
19th World Conference on Lung Cancer, Sep. 2018. Hiromitsu Takizawa, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
CT and PET/CT Parameters of Lepidic Predominant Pattern Lung Adenocarcinoma and Invasiveness on Pathology,
19th World Conference on Lung Cancer, Sep. 2018. Kazuya Kondo, Soejima Shiho, wusiman nuliamina, Kishibuchi Reina, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
The expression of DNA methylation of GAD1 gene is an indicator of malignant behavior in thymic epithelial tumor,
19th World Conference on Lung Cancer, Sep. 2018. Seiya Inoue, Masakazu Goto, Takeshi Nishino, Takahiro Yoshida and Akira Tangoku :
Oral PresentationTreatment Strategy of Esophageal Cancer from the Expression of HER2 and EGFR,
International Society for Diseases of the Esophagus, Sep. 2018. Takeshi Nishino, Hiroaki Toba, Takahiro Yoshida, Seiya Inoue, Masakazu Goto and Akira Tangoku :
Oral PresentationDiagnostic Utility of Endobronchial Ultrasonography for the Tracheobronchial Invasion of Esophageal Cancer,
International Society for Diseases of the Esophagus, Sep. 2018. Akira Tangoku, Takeshi Nishino, Seiya Inoue, Masakazu Goto and Takahiro Yoshida :
The Effects of the Herbal Medicine Daikenchuto(Tj-100) after Esophageal Cancer Resection, Open-Label, Randomized Controlled Trial,
Esophagus, Vol.15, No.2, 75-82, Sep. 2018.

(要約): Daikenchuto (TJ-100), a traditional Japanese herbal medicine, is widely used in Japan. Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known. The purpose of this prospective randomized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients. Forty patients for whom subtotal esophageal resection for esophageal cancer was planned at our institute from March 2011 to August 2013 were enrolled and divided into two groups at the point of determination of the operation schedule after informed consent was obtained: a TJ-100 (15 g/day)-treated group (n = 20) and a control group (n = 20). The primary efficacy end-points were maintenance of the nutrition condition and the recovery of gastrointestinal function. The secondary efficacy end-points were the serum C-reactive protein (CRP) level and adrenomedullin level during the postoperative course, the incidence of postoperative complications, and the length of hospital stay after surgery. We examined 39 patients because one patient in the TJ-100 group was judged as having unresectable cancer after surgery. The mean age of the TJ-100 group patients was significantly older than that of the control group patients.The rate of body weight decrease at postoperative day 21 was significantly suppressed in the TJ-100 group (3.6% vs. the control group: 7.0%, p = 0.014), but the serum albumin level was not significantly different between the groups. The recovery of gastrointestinal function regarding flatus, defecation, and oral intake showed no significant between-group differences, but postoperative bowel symptoms tended to be rare in the TJ-100 group. There was no significant between-group difference in the length of hospital stay after surgery. The serum CRP level at postoperative day 3 was 4.9 mg/dl in the TJ-100 group and 6.9 mg/dl in the control group, showing a tendency of a suppressed serum CRP level in the TJ-100 group (p = 0.126). The rate of increase in adrenomedullin tended to be high postoperatively, but there was no significant difference between the two groups. TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss, and it might suppress the excess inflammatory reaction related to surgery.
(キーワード): Adrenomedullin / Aged / C-Reactive Protein / Defecation / Eating / Esophageal Neoplasms / Esophagectomy / Female / Gastrointestinal Tract / Humans / Length of Stay / Male / Middle Aged / Nutritional Status / Phytotherapy / Plant Extracts / Postoperative Complications / Prospective Studies / Recovery of Function / Serum Albumin / Weight Loss
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10388-017-0601-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29892933; ● Summary page in Scopus @ Elsevier: 2-s2.0-85038619573

(DOI: 10.1007/s10388-017-0601-9, PubMed: 29892933, Elsevier: Scopus) Satomi Moriyama, Daisuke Hinode, Masami Yoshioka, Yuka Sogawa, Takeshi Nishino, Akira Tangoku and Daniel Grenier :
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(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-015-0597-8
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25814093; ● Summary page in Scopus @ Elsevier: 2-s2.0-84925651439

(DOI: 10.1007/s12282-015-0597-8, PubMed: 25814093, Elsevier: Scopus) Akira Tangoku :
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Timely Multimodality Therapy can realize long Survival for Advanced Espophageal Cancer Patients with Esophago-Broncheal Fistula,
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(キーワード): bio-impedance / tissue equivalent circuit model / Gauss-Newton metohd

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(文献検索サイトへのリンク): ● Summary page in Scopus @ Elsevier: 2-s2.0-33846900947

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第31回日本乳癌検診学会学術総会(ハイブリッド開催), 2021年11月. 井上寛章, 笹聡一郎, 乾友浩, 青山万理子, 奥村和正, 鳥羽博明, 吉田卓弘, 滝沢宏光, 丹黒章 :
当院におけるAYA世代乳癌患者の発見契機と予後について,
第31回日本乳癌検診学会学術総会(ハイブリッド開催), 2021年11月. 牧秀則, 井上聖也, 南城和正, 青山万理子, 後藤正和, 西野豪志, 吉田卓弘, 滝沢宏光, 丹黒章 :
巨大食道裂孔ヘルニアを伴う特発性食道破裂の一例,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 南城和正, 井上聖也, 牧秀則, 庄野隆志, 青山万理子, 西野豪志, 後藤正和, 吉田卓弘, 滝沢宏光, 丹黒章 :
食道癌術後に門脈ガス血症・腸管気腫症を発症した1例,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
食道癌に対する縦隔鏡・胸腔鏡併用による合理的な縦隔リンパ節郭清,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 吉田卓弘, 西野豪志, 井上聖也, 藤原聡史, 後藤正和, 丹黒章 :
食道胃接合部癌におけるリンパ流の検討,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 後藤正和, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章 :
The investigation of anastomotic stricture after esophagectomy,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 庄野隆志, 井上聖也, 南城和正, 西條康代, 牧秀則, 青山万理子, 西野豪志, 後藤正和, 吉田卓弘, 滝沢宏光, 丹黒章 :
術前化学療法に効果を示し，根治手術を施行した進行食道粘表皮癌の1例,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 庄野隆志, 南城和正, 牧秀則, 青山万理子, 丹黒章, 橋本脩平, 濵田康弘 :
当院の食道癌集学的チーム医療の現状と栄養評価,
第75回日本食道学会学術集会(ハイブリッド開催), 2021年9月. 吉田卓弘, 後藤正和, 井上聖也, 藤原聡史, 滝沢宏光, 丹黒章, 西野豪志 :
反回神経麻痺回避のための左頸部アポローチによる縦隔鏡下左反回神経周囲リンパ節郭清の工夫,
第96回中国四国外科学会総会・第26回中国四国内視鏡外科研究会, 2021年9月. 奥村和正, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 鳥羽博明, 丹黒章 :
術後補助療法としてのTC療法の治療成績の検討,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 笹聡一郎, 乾友浩, 青山万理子, 井上寛章, 奥村和正, 鳥羽博明, 丹黒章 :
乳癌術前化学療法におけるアルブミン懸濁型パクリタキセルの使用経験,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 青山万理子, 井上寛章, 乾友浩, 笹聡一郎, 奥村和正, 鳥羽博明, 坂東良美, 丹黒章 :
浸潤性小葉癌の病変の広がり診断についての検討-画像所見と病理学的所見との相関に注目して-,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 井上寛章, 笹聡一郎, 青山万理子, 乾友浩, 奥村和正, 鳥羽博明, 宮本直輝, 丹黒章 :
高齢乳癌患者におけるCARGスコアは予後予測因子になるか?,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 奥村和正, 鳥羽博明, 丹黒章 :
当院における乳癌脳転移症例の検討,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 山尾雅美, 山口夏美, 松本麻依, 平田有紀奈, 西尾進, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 奥村和正, 鳥羽博明, 尾矢剛志, 坂東良美, 佐田政隆, 丹黒章 :
硬化性腺症を背景に発生した悪性葉状腫瘍の1例,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 鳥羽博明, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 奥村和正, 丹黒章 :
かかりつけ医と役割分担してより良い乳癌診療をするための包括的な取り組み,
第29回日本乳癌学会学術総会(ハイブリッド開催), 2021年7月. 坂本晋一, 滝沢宏光, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
左B1+2転位気管支とV1+2の走行異常を認める左下葉肺癌の一切除例,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 松本大資, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
コイルと色素を併用した気管支鏡下マーキング法による，触知困難小型病変に対する単孔式胸腔鏡下肺部分切除,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 髙嶋美佳, 鳥羽博明, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
進行食道癌による気道のEmergencyに対する気道ステント留置例の検討,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 滝沢宏光, 河北直也, 庄野隆志, 南城和正, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
当科におけるCone-beam CT vs EBUS-GSガイド下経気管支生検による原発性肺癌診断の成績比較,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 河北直也, 滝沢宏光, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
原発性肺癌診断におけるCone-beam CT vs CTガイド下気管支鏡下生検,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
術前化学療法時からの専門的口腔機能管理が食道癌術後の長期予後を改善する,
第46回日本外科系連合学会学術集会(Web開催), 2021年6月. 後藤正和, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章 :
The difference of expression of chemokines and their receptors in esophageal cancer,
第64回関西胸部外科学会学術集会(Web開催), 2021年6月. 庄野隆志, 青山万理子, 南城和正, 山本清成, 牧秀則, 乾友浩, 坂本晋一, 小林智子, 中村信元, 滝沢宏光, 丹黒章 :
アブスコパル効果を示した甲状腺原発形質細胞腫の1例,
第33回日本内分泌外科学会総会, 2021年6月. 山本清成, 青山万理子, 滝沢宏光, 南城和正, 庄野隆志, 牧秀則, 乾友浩, 坂本晋一, 丹黒章 :
右心房転移をきたした甲状腺未分化癌の1例,
第33回日本内分泌外科学会総会, 2021年6月. 坂本晋一, 青山万理子, 滝沢宏光, 庄野隆志, 山本清成, 丹黒章 :
低用量レンバチニブ投与で病勢コントロールを得た甲状腺乳頭癌の3例,
第33回日本内分泌外科学会総会, 2021年6月. 青山万理子, 滝沢宏光, 庄野隆志, 山本清成, 乾友浩, 坂本晋一, 丹黒章 :
原発性副甲状腺機能亢進症術後のテタニー発症の術前因子についての検討,
第33回日本内分泌外科学会総会, 2021年6月. 滝沢宏光, 青山万理子, 庄野隆志, 南城和正, 山本清成, 乾友浩, 坂本晋一, 丹黒章 :
レンバチニブが甲状腺乳頭癌多発肺転移と腎細胞癌に有効であった1例,
第33回日本内分泌外科学会総会, 2021年6月. 山本清成, 河北直也, 鳥羽博明, 南城和正, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
pStageⅠ肺腺癌におけるVolume doubling timeとSUVmax，優位組織亜型の関係,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 鳥羽博明, 河北直也, 髙嶋美佳, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
右B2転位気管支・V2破格・上下葉間分葉不全を伴う右下葉肺癌症例に対するRATS,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 庄野隆志, 滝沢宏光, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 吉田光輝, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
網膜芽細胞腫治療後に後縦隔に発生した平滑筋肉腫の一例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肺癌手術におけるICG蛍光を用いた気管支動脈可視化の意義,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 宮本直輝, 近藤和也, 南城和正, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
当院で経験したmicronodular thymic tumorの3例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 髙嶋美佳, 鳥羽博明, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
悪性気道狭窄に対する気道ステント留置例の検討,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 河北直也, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
浸潤径・SUVmaxで簡便にpStageⅠ肺腺癌の予後を層別化できる,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 坂本晋一, 河北直也, 鳥羽博明, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
間質性肺炎合併肺癌に対する予後予測因子の検討,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 松本大資, 鳥羽博明, 坂本晋一, 髙嶋美佳, 河北直也, 庄野隆志, 南城和正, 牧秀則, 山本清成, 宮本直輝, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
ラット胎仔肺移植による肺再生へのアプローチ,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 吉田光輝, 近藤和也, 湯浅将生, 宮本直輝, 川上行奎, 山本清成, 南城和正, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 滝沢宏光, 丹黒章 :
CT画像から胸腺の手術を考える,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 吉田光輝, 大石久, 宮本直輝, 近藤和也, 川上行奎, 南城和正, 山本清成, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 滝沢宏光, 丹黒章 :
トランスレーショナルリサーチに必ず必要な外科技術-呼吸器外科から創薬への社会貢献を-,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 松本大資, 河北直也, 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肺切除術後に気管支鏡処置が必要な無気肺を発症するハイリスク患者群の抽出,
第121回日本外科学会定期学術集会, 2021年4月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
頸・腹同時進行による縦隔鏡下食道切除術の工夫-われわれのこだわり-,
第121回日本外科学会定期学術集会, 2021年4月. 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
発達した気管支動脈は術中出血と手術時間延長のリスク因子である,
第121回日本外科学会定期学術集会, 2021年4月. 吉田卓弘, 丹黒章, 西野豪志, 井上聖也, 後藤正和 :
食道胃接合部表在癌に対する術前CTリンパ管造影による郭清範囲決定,
第121回日本外科学会定期学術集会, 2021年4月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 溝渕海, 竹原恵美, 青山万理子, 森本雅美, 丹黒章 :
当科における縦隔鏡下食道切除術の安全性に関する検討,
第33回日本内視鏡外科学会総会(ハイブリッド開催), 2021年3月. 石澤有紀, 三成美保, 坂東良美, 住谷さつき, 丹黒章, 葉久真理 :
研究に関する男女共同参画・ダイバーシティの推進状況に関するアンケート調査 -全国の集計結果との比較から見える徳島大学の現状-,
第262回徳島医学会学術集会(令和2年度冬期), 2021年3月. 宮本直輝, 近藤和也, 南城和正, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
診断に苦慮したmicronodular thymic carcinomaの1例,
第40回日本胸腺研究会, 2021年2月. 六車京香, 近藤和也, 副島志帆, Bilguun tegshee, 山下理子, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるMT1A遺伝子のDNAメチル化とmRNA発現,
第40回日本胸腺研究会, 2021年2月. 髙嶋美佳, 鳥羽博明, 井上聖也, 西野豪志, 吉田卓弘, 清家純一, 丹黒章 :
進行食道癌による気道のEmergencyに対する気道ステント留置例の検討,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 鳥羽博明, 吉田卓弘, 髙嶋美佳, 井上聖也, 後藤正和, 西野豪志, 清家純一, 丹黒章 :
かかりつけ医と連携してより良い食道癌診療をするための包括的な取り組み,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 溝渕海, 鈴木恵美, 青山万理子, 森本雅美, 丹黒章 :
縫合不全回避のためのわれわれの工夫,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章 :
切除可能胸部食道癌に対する術前DTX+5-FU+CDDP療法の個別治療と組織学的評価の意義,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
食道癌手術における縦隔鏡アプローチの進歩と現状,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 丹黒章 :
《会長講演》邂逅そして創造,
第74回日本食道学会学術集会(ハイブリッド型開催), 2020年12月. 近藤心, 吉田卓弘, 斎藤貴, 小野玲, 鎌田基夢, 佐藤紀, 井上聖也, 西野豪志, 丹黒章, 加藤真介 :
胸部食道癌切除術を施行した患者の術前運動耐用能は術後2年生存率に影響する,
日本食道学会学術集会プログラム・抄録集, 226, 2020年12月.

(キーワード): *運動負荷試験 *食道腫瘍(外科的療法,予後) *食道切除術前評価生存率ヒト男女

笹聡一郎, 井上寛章, 奥村和正, 青山万理子, 乾友浩, 鳥羽博明, 丹黒章 :
当施設におけるステレオガイド下マンモトーム生検の検討,
第30回日本乳癌検診学会学術総会(ハイブリッド形式), 2020年11月. 乾友浩, 井上寛章, 笹聡一郎, 青山万理子, 奥村和正, 鳥羽博明, 吉田卓弘, 坂東良美, 丹黒章 :
精査機関である当院における針生検の現状,
第30回日本乳癌検診学会学術総会(ハイブリッド形式), 2020年11月. 田中眞紀, 石田孝宣, 大貫幸二, 渡辺良二, 吉田雅行, 小山智美, 丹黒章, 大内憲明, 中島康雄 :
乳がん検診にあたっての新型コロナウィルス感染症(COVID-19)への対応への手引き,
第30回日本乳癌検診学会学術総会(ハイブリッド形式), 2020年11月. 吉田光輝, 近藤和也, 坂東良美, 竹原恵美, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
診断と治療に苦慮した前縦隔粘液線維肉腫の経験,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 副島志帆, 近藤和也, 坪井光弘, 梶浦耕一郎, 六車京香, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍の悪性度とGAD1遺伝子のDNAメチル化と発現,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 張林婉, 近藤和也, 板東孝枝, 今井芳枝, 髙橋亜希, 荒堀広美, 姚人尹, 滝沢宏光, 川上行奎, 吉田光輝, 鳥羽博明, 坪井光弘, 丹黒章 :
手術療法施行した肺がん患者におけるpatient reported quality of life(PRQOL)の評価,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
蛍光顕微鏡を用いた小型肺腺癌浸潤診断についての検討,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 松本大資, 鳥羽博明, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
切除可能cI-ⅢA期肺扁平上皮癌における術後再発リスクの層別化と治療戦略,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 髙嶋美佳, 鳥羽博明, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
アダプター蛋白XB130はⅠ期肺腺癌の予後因子となり得る,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 河北直也, 鳥羽博明, 滝沢宏光, 南城和正, 庄野隆志, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
小型末梢肺癌診断率向上のためのCone-beam CT併用極細径気管支鏡下生検,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. Tegshee Bilguun, 近藤和也, 副島志帆, 六車京香, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
Expression of variant ligand and receptor of Ghrelin system is related to tumorigenesis of thymoma,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 鳥羽博明, 滝沢宏光, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
高齢肺癌患者を地域で役割分担して診るための包括的な取り組み,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 南城和正, 吉田光輝, 東桃代, 庄野隆志, 山本清成, 牧秀則, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
呼吸器外科からみた結核スクリーニング-T-SPOT検査は有用か-,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 宮本直輝, 南城和正, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光, 丹黒章 :
原発性肺癌術後オリゴ肺転移症例についての検討,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 青山万理子, 河北直也, 滝沢宏光, 丹黒章 :
生検組織を用いた食道扁平上皮癌に対する初回化学療法の効果と予後予測因子の解明,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 山本清成, 西野豪志, 庄野隆志, 南城和正, 牧秀則, 髙嶋美佳, 松本大資, 河北直也, 井上聖也, 後藤正和, 吉田卓弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
気管分岐部狭窄を伴う気管支瘻形成進行食道癌に対する集学的治療の経験,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 滝沢宏光, 南城和正, 庄野隆志, 山本清成, 牧秀則, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
CTリンパ管造影による肺癌センチネルリンパ節マップの検討,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
根治性と合併症軽減の両立を目指した縦隔鏡下リンパ節郭清手技,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 南城和正, 庄野隆志, 牧秀則, 山本清成, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
分類不能型縦隔高悪性度腫瘍の手術例の経験,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章, 鶴尾吉宏, 青山万理子, 鳥羽博明, 滝沢宏光 :
食道外科手術におけるカダバートレーニングの経験と展望,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 髙嶋美佳, 鳥羽博明, 滝沢宏光, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
地方で働く一呼吸器外科医としての現在地，そしてこれから,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 丹黒章 :
《特別企画》食道外科における2030年の展望,
第73回日本胸部外科学会定期学術集会, 2020年10月. 丹黒章 :
《分野会長講演(食道)》食道癌外科治療における最新の話題,
第73回日本胸部外科学会定期学術集会, 2020年10月. 庄野隆志, 西野豪志, 南城和正, 山本清成, 牧秀則, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 井上聖也, 後藤正和, 奥村和正, 吉田卓弘, 丹黒章 :
乳癌術後20年目に食道転移をきたした1例,
第82回日本臨床外科学会総会, 2020年10月. 西野豪志, 吉田卓弘, 庄野隆志, 南城和正, 牧秀則, 山本清成, 井上聖也, 後藤正和, 丹黒章 :
縦隔鏡下食道癌根治術における縦隔リンパ節郭清の工夫,
第82回日本臨床外科学会総会, 2020年10月. 庄野隆志, 井上寛章, 山本清成, 乾友浩, 宮本直輝, 笹聡一郎, 青山万理子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
腹膜播種によるイレウスに対しベバシズマブ+パクリタキセル療法が著効した再発乳癌の1例,
第17回日本乳癌学会中国四国地方会(Web開催), 2020年10月. 宮本直輝, 井上寛章, 笹聡一郎, 鳥羽博明, 森本雅美, 武知浩和, 青山万理子, 竹原恵美, 溝渕海, 丹黒章 :
HER2陽性乳癌患者における末梢血リンパ球数，好中球リンパ球比についての検討,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 井上寛章, 笹聡一郎, 鳥羽博明, 森本雅美, 武知浩和, 青山万理子, 宮本直輝, 竹原恵美, 溝渕海, 丹黒章 :
CARGスコアは高齢者乳癌患者の薬物療法決定に際し有用か?,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 武知浩和, 松岡由江, 一宮由貴, 三木幸代, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 鳥羽博明, 吉田卓弘, 丹黒章 :
乳房再建により急速に鬱症状が改善した1例,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 森本雅美, 宮本容子, 吉田友紀子, 笹聡一郎, 青山万理子, 井上寛章, 鳥羽博明, 武知浩和, 丹黒章 :
臨床遺伝診療部の従事者間で治療方針を決定したBRCAバリアントの1症例,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 竹原恵美, 井上寛章, 笹聡一郎, 森本雅美, 武知浩和, 鳥羽博明, 青山万理子, 宮本直輝, 溝渕海, 丹黒章 :
当院における葉状腫瘍の経験とフォローアップの重要性,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 山口美代子, 松岡由江, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 武知浩和, 丹黒章 :
乳癌患者に対する多職種カンファレンスの充実に向けた取り組み,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 笹聡一郎, 井上寛章, 森本雅美, 武知浩和, 丹黒章 :
当科で治療を行ったAYA世代乳癌症例の検討,
第28回日本乳癌学会学術総会(Web開催), 2020年10月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 坂本晋一, 監﨑孝一郎, 久保尊子, 法村尚子, 鳥羽博明, 吉田光輝, 滝沢宏光, 三浦一真, 丹黒章 :
ロボット支援下肺葉切除術導入における助手の役割,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 牧秀則, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 髙嶋美佳, 河北直也, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
微小肺病変に対して術中Cone-beam CT併用気管支鏡下コイルマーキングが有用であった1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 宮本直輝, 南城和正, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腔鏡下に確定診断を得たCalcifying fibrous tumorの1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
甲状腺未分化癌同所移植マウスモデルと小動物用FDG-PET/CTを用いた分子標的治療効果判定法の確立,
第24回日本がん分子標的治療学会学術集会(ハイブリッド形式), 2020年10月. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 新沼猛, 鈴木拓, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
新規癌抑制遺伝子SALL3はトリプルネガティブ乳癌の薬剤抵抗性に関与する,
第79回日本癌学会学術総会, 2020年10月. 髙嶋美佳, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
神経線維腫症1型を背景とした肋間動脈瘤破裂による血胸に対しソフト凝固により止血し得た1例,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
大腸癌肺転移の肺切除後再発リスク因子,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 河北直也, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 髙嶋美佳, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
ステロイドが遷延性肺瘻に与える影響,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 松本大資, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
コイルと色素を併用した気管支鏡下コイルマーキング法による，触知困難小型病変に対する単孔式胸腔鏡下肺部分切除,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 鳥羽博明, 滝沢宏光, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
かかりつけ医と連携してより良い肺癌診療をするための包括的な取り組み,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 坪井光弘, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
進行期胸腺上皮性腫瘍の治療成績の検討,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 吉田光輝, 近藤和也, 大谷環樹, 小川博久, 宮本直輝, 竹原恵美, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
呼吸器外科の癌免疫療法研究-CMT167マウス肺癌細胞株同所移植モデルマウスの確立に向けて-,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 溝渕海, 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 青山万理子, 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 坪井光弘, 丹黒章 :
自家蛍光による副甲状腺の同定-励起光による自家蛍光の変化に注目して-,
第32回日本内分泌外科学会総会, 2020年9月. 青山万理子, 滝沢宏光, 井上聖也, 河北直也, 坪井光弘, 近藤和也, 丹黒章 :
小動物用FDG-PET/CTを使用した甲状腺未分化癌の同所移植マウスモデルの作成,
第120回日本外科学会定期学術集会(Web開催), 2020年8月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章 :
術前CTリンパ管造影により得られる食道胃接合部癌に対する至適リンパ節郭清,
第120回日本外科学会定期学術集会(Web開催), 2020年8月. 井上寛章, 鳥羽博明, 笹聡一郎, 森本雅美, 武知浩和, 兼松美幸, 竹原恵美, 溝渕海, 丹黒章 :
TILsは薬物療法効果予測因子となるか:S-1+低用量ドセタキセルを用いた術前化学療法(N-1 study)における検討,
第120回日本外科学会定期学術集会(Web開催), 2020年8月. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 丹黒章 :
食道切除術後の心房細動に対する予防的ランジオロール投与の効果,
第63回関西胸部外科学会学術集会(Web開催), 2020年8月. 松本大資, 河北直也, 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
気管支鏡処置を要する術後無気肺発症のハイリスク患者群の抽出,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 滝沢宏光, 河北直也, Eman Ali, 坪井光弘, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
当科における経気管支生検時併用モダリティ別の診断成績比較Cone-beam CT vs EBUS-GS,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 河北直也, 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTを用いた極細径気管支鏡下生検,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 髙嶋美佳, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
進行食道癌による気道狭窄に対するステント留置例の検討,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 吉田光輝, 峯田一秀, 河北直也, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
皮膚移植とBACシステムを組み合わせた有瘻性膿胸の治療経験-開創術後のマネジメントにいかに立ち向かうか,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 副島志帆, 近藤和也, 六車京香, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるghrelin-GHSR系分子の発現,
第39回日本胸腺研究会, 2020年2月. 六車京香, 近藤和也, 副島志帆, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるNPTX2遺伝子のDNAメチル化とmRNA，タンパク発現の関係,
第39回日本胸腺研究会, 2020年2月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 鈴木恵美, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第39回日本胸腺研究会, 2020年2月. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 新沼猛, 鈴木拓, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
トリプルネガティブ乳癌の薬剤抵抗性に関与する新規癌抑制遺伝子SALL3の分子機構解明,
第1回日本癌学会若手の会, 2020年2月. 高嶋美佳, 鳥羽博明, 柿内聡司, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管瘻を伴った進行肺癌による気道狭窄に対し気道ステント留置により長期にわたり良好なQOLを維持できた1例,
第60回日本肺癌学会学術集会, 2019年12月. 吉田光輝, 小川博久, 湯浅将生, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
定量的三次元CT解析から上皮内癌，微小浸潤癌を予測できるか,
第60回日本肺癌学会学術集会, 2019年12月. 坪井光弘, 近藤和也, 副島志帆, 六車京香, 溝渕海, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
クロム工場従事者の肺癌におけるMLH1遺伝子のメチル化の検討,
第60回日本肺癌学会学術集会, 2019年12月. 副島志帆, 近藤和也, 岸渕麗奈, 六車京香, 坪井光弘, 梶浦耕一郎, Bilguun Tegshee, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍の悪性度の指標としてのGHSRのDNAメチル化,
第60回日本肺癌学会学術集会, 2019年12月. 六車京香, 近藤和也, 副島志帆, 岸渕麗奈, Bilguunmin Tegshee, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるMT1AとNPTX2遺伝子のDNAメチル化とmRNAの発現の関係,
第60回日本肺癌学会学術集会, 2019年12月. 松本大資, 鳥羽博明, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 高嶋美佳, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
右肺動脈閉鎖症を伴う右下葉肺癌に対し，胸腔鏡下肺葉切除を行った1例,
第60回日本肺癌学会学術集会, 2019年12月. 鳥羽博明, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
胸腔鏡困難症例をやりやすくするための少しの工夫とリスクマネジメント,
第32回日本内視鏡外科学会総会, 2019年12月. 西野豪志, 井上聖也, 後藤正和, 吉田卓弘, 丹黒章 :
根治を目指した縦隔鏡下食道切除術:縦隔リンパ節郭清の工夫と定型化,
第32回日本内視鏡外科学会総会, 2019年12月. 滝沢宏光, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
蛍光顕微鏡を用いた肺腺癌浸潤診断についての検討,
第60回日本肺癌学会学術集会, 2019年12月. 古北由仁, 吉田卓弘, 井上聖也, 後藤正和, 西野豪志, 丹黒章 :
食道癌における腫瘍内リンパ球浸潤は化学療法の治療効果を予見する?,
第32回日本バイオセラピィ学会学術集会総会, 2019年11月. 宮本直輝, 吉田光輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 滝沢宏光, 丹黒章 :
胸腔鏡下生検で確定診断を得たCalcifying fibrous tumorの1例,
第62回日本呼吸器学会中国・四国地方会, 2019年11月. 竹原恵美, 鳥羽博明, 溝渕海, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
ニボルマブが奏功し，長期間休止後増悪時に再投与した切除不能肺癌の1例,
第81回日本臨床外科学会総会, 2019年11月. 笹聡一郎, 井上寛章, 兼松美幸, 森本雅美, 武知浩和, 丹黒章 :
治療方針決定に難渋した授乳性腺腫の1例,
第81回日本臨床外科学会総会, 2019年11月. 溝渕海, 井上聖也, 吉田卓弘, 西野豪志, 竹原恵美, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 武知浩和, 丹黒章 :
食道閉鎖症に対する再建結腸に発生した結腸癌の1切除例,
第81回日本臨床外科学会総会, 2019年11月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 溝渕海, 竹原恵美, 丹黒章 :
当院における下咽頭癌に対する他科連携手術,
第81回日本臨床外科学会総会, 2019年11月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 溝渕海, 竹原恵美, 青山万理子, 笹聡一郎, 井上寛章, 森本雅美, 兼松美幸, 坪井光弘, 武知浩和, 丹黒章 :
食道癌術後における大建中湯投与の有効性-術後早期から晩期までの効果-,
第81回日本臨床外科学会総会, 2019年11月. 井上聖也, 吉田卓弘, 西野豪志, 溝渕海, 竹原恵美, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 武知浩和, 丹黒章 :
胃管穿孔，膿胸，難治性消化管皮膚瘻，出血性ショックを伴う瘻孔出血を来し，度重なる手術を必要とした1例,
第81回日本臨床外科学会総会, 2019年11月. 鳥羽博明, 滝沢宏光, 吉田卓弘, 森本雅美, 青山万理子, 武知浩和, 丹黒章 :
がんの地域連携におけるかかりつけ医とのより早期からの情報交換と役割分担の重要性∼患者にとって良い連携体制構築のための包括的な取り組み,
第81回日本臨床外科学会総会, 2019年11月. 滝沢宏光, 鳥羽博明, 松本大資, 竹原恵美, 宮本直輝, 高嶋美佳, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《クリニカルビデオセッション》胸腔シミュレータと3D臓器モデルを用いたロボット支援胸腔鏡下肺葉切除の術前トレーニング,
第72回日本胸部外科学会定期学術集会, 2019年10月. 吉田光輝, 小川博久, 湯浅将生, 鈴木恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
上皮内癌，微小浸潤癌の三次元画像解析,
第72回日本胸部外科学会定期学術集会, 2019年10月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 高嶋美佳, 鳥羽博明, 滝沢宏光, 丹黒章 :
《パネルディスカッション》隣接臓器浸潤を伴う局所進行食道癌に対する集学的治療Oncological Emergencyへの対応と食道バイパス手術併用によるQOLの評価,
第72回日本胸部外科学会定期学術集会, 2019年10月. 西野豪志, 井上聖也, 後藤正和, 吉田卓弘, 丹黒章 :
《ビデオシンポジウム》縦隔鏡下食道癌根治術における最適な縦隔リンパ節郭清とは,
第72回日本胸部外科学会定期学術集会, 2019年10月. 丹黒章 :
《特別企画》開胸手術から胸腔鏡下食道切除術，NCDデータによる低侵襲性の検証，根治を目指す縦郭鏡下手術とロボティックサージェリー，術前化学療法そしてEarly Recovery After Surgeryなど,
第72回日本胸部外科学会定期学術集会, 2019年10月. 武知浩和, 溝渕海, 笹聡一郎, 青山万理子, 森本雅美, 井上寛章, 兼松美幸, 鳥羽博明, 吉田卓弘, 丹黒章 :
周術期乳癌に対するアルブミン懸濁型パクリタキセルの有効性についての検討,
第57回日本癌治療学会学術集会, 2019年10月. 西野豪志, 井上聖也, 後藤正和, 吉田卓弘, 丹黒章 :
食道癌の気管・気管支浸潤の診断における超音波気管支鏡の有用性,
第57回日本癌治療学会学術集会, 2019年10月. 河北直也, 滝沢宏光, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対するインドシアニングリーン蛍光下手術,
第57回日本癌治療学会学術集会, 2019年10月. 澤田徹, 滝沢宏光, 青山万理子, 竹原恵美, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
共焦点レーザー内視鏡における肺癌胸膜浸潤診断の有用性について,
第57回日本癌治療学会学術集会, 2019年10月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
甲状腺原発悪性リンパ腫の診断における穿刺吸引細胞診の有用性について,
第52回日本内分泌外科学会学術集会, 2019年10月. 坪井光弘, 青山万理子, 滝沢宏光, 丹黒章 :
3mm assist portを併用した内視鏡下甲状腺悪性腫瘍手術,
第52回日本内分泌外科学会学術集会, 2019年10月. 武知浩和, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 兼松美幸, 鳥羽博明, 吉田卓弘, 丹黒章 :
当科における乳房一次再建術適応,
第7回日本乳房オンコプラスティックサージャリー学会総会, 2019年10月. 松下洋輔, 奥村和正, 小松正人, 木村竜一朗, 吉丸哲郎, 尾野雅哉, 本田純子, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
RHBDL2によるグルタミノリシスの制御はTNBCの悪性化や抗癌剤抵抗性に関連する,
第78回日本癌学会学術総会, 2019年9月. 吉田卓弘, 西野豪志, 井上聖也, 溝渕海, 後藤正和, 丹黒章 :
75歳以上胸部食道癌における手術治療に関する検討,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 青山万理子, 滝沢宏光, 溝渕海, 竹原恵美, 坪井光弘, 丹黒章 :
内科治療抵抗性のBasedow病に手術を施行した1例,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 滝沢宏光, 鳥羽博明, 松本大資, 高嶋美佳, 竹原恵美, 宮本直輝, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下肺葉切除導入期における3D臓器モデルを用いた術前シミュレーション,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 竹原恵美, 滝沢宏光, 溝渕海, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
卒後3年目後期研修医が経験した胸腔鏡下肺悪性腫瘍手術の修練,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 溝渕海, 井上聖也, 吉田卓弘, 西野豪志, 竹原恵美, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 武知浩和, 丹黒章 :
食道閉鎖症に対する再建結腸に発生した結腸癌の1切除例,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 鳥羽博明, 滝沢宏光, 吉田卓弘, 森本雅美, 青山万理子, 武知浩和, 丹黒章 :
より良いがんの地域連携体制構築のためのmulti-modalな取り組み,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 吉田光輝, 山上真樹子, 丹黒章, 北市隆, 西正暁, 滝沢宏光, 石橋広樹, 島田光生 :
徳島大学外科専門医研修プログラムの現状と今後の課題,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 笹聡一郎, 井上寛章, 兼松美幸, 森本雅美, 武知浩和, 丹黒章 :
副乳発生と考えられた腋窩線維腺腫の1例,
第16回日本乳癌学会中国四国地方会, 2019年9月. 森本雅美, 笹聡一郎, 青山万理子, 井上寛章, 河北直也, 兼松美幸, 鳥羽博明, 武知浩和, 丹黒章 :
ベバシズマブ投与中に気胸を繰り返した薄壁空洞形成乳癌肺転移の1例,
第16回日本乳癌学会中国四国地方会, 2019年9月. 兼松美幸, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 鳥羽博明, 武知浩和, 丹黒章 :
多発脳転移の治療中にステロイド精神病をきたした1例,
第16回日本乳癌学会中国四国地方会, 2019年9月. 武知浩和, 一宮由貴, 松岡由江, 三木幸代, 笹聡一郎, 青山万理子, 井上寛章, 森本雅美, 兼松美幸, 鳥羽博明, 丹黒章 :
早朝からの正確な病状説明が患者の信頼感獲得につながっていると思われる症例,
第16回日本乳癌学会中国四国地方会, 2019年9月. 森本雅美, 笹聡一郎, 青山万理子, 鳥羽博明, 武知浩和, 丹黒章 :
エリブリン治療前後のNLRは進行再発乳癌の治療効果と相関する可能性がある,
第17回日本臨床腫瘍学会学術集会, 2019年7月. 武知浩和, 森本雅美, 鳥羽博明, 笹聡一郎, 青山万理子, 井上寛章, 兼松美幸, 井上聖也, 吉田卓弘, 丹黒章 :
HER2 type乳癌初期治療時におけるアンスラサイクリン系抗癌剤回避レジメンの有効性,
第17回日本臨床腫瘍学会学術集会, 2019年7月. 井上聖也, 吉田卓弘, 西野豪志, 鈴木恵美, 山田亮, 笹聡一郎, 青山万理子, 兼松美幸, 武知浩和, 丹黒章 :
食道癌手術における再建経路のBEST Choice,
第74回日本消化器外科学会総会, 2019年7月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章 :
Strategies based on the efficacy of preoperative DCF in cStage II,III thoracic esophageal cancer,
第74回日本消化器外科学会総会, 2019年7月. 竹原恵美, 滝沢宏光, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
急速増大を示したLCNECの一切除例,
第58回日本肺癌学会中国・四国支部学術集会, 2019年7月. 丹黒章 :
《専門医制度委員会報告》施設認定委員会からの報告,
第27回日本乳癌学会学術総会, 2019年7月. 笹聡一郎, 池内真由美, 兼松美幸, 森本雅美, 武知浩和, 丹黒章 :
治療方針の決定に難渋した非浸潤性小葉癌の1症例,
第27回日本乳癌学会学術総会, 2019年7月. 兼松美幸, 笹聡一郎, 池内真由美, 森本雅美, 鳥羽博明, 武知浩和, 丹黒章 :
術前化学療法中に発症した薬剤性間質性肺炎の3例,
第27回日本乳癌学会学術総会, 2019年7月. 武知浩和, 森本雅美, 鳥羽博明, 一宮由貴, 松岡由江, 三木幸代, 笹聡一郎, 池内真由美, 兼松美幸, 吉田卓弘, 丹黒章 :
転移・再発乳癌におけるAdvanced care planningについて,
第27回日本乳癌学会学術総会, 2019年7月. 中川美砂子, 池内真由美, 兼松美幸, 森本雅美, 武知浩和, 鳥羽博明, 吉田卓弘, 丹黒章 :
CTリンパ管造影を用いたセンチネルリンパ節の術前転移診断,
第27回日本乳癌学会学術総会, 2019年7月. 鳥羽博明, 中川美砂子, 日野直樹, 笹聡一郎, 池内真由美, 兼松美幸, 森本雅美, 武知浩和, 吉田卓弘, 丹黒章 :
S-1/Docetaxelによる術前化学療法第Ⅱ相試験の長期成績,
第27回日本乳癌学会学術総会, 2019年7月. 森本雅美, 阿部彰子, 笹聡一郎, 池内真由美, 兼松美幸, 鳥羽博明, 武知浩和, 桑原章, 丹黒章 :
当院における乳癌患者に対する妊孕性温存の取り組み,
第27回日本乳癌学会学術総会, 2019年7月. 坪井光弘, 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
極細径気管支鏡下肺生検における到達困難な末梢病変の検討,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 澤田徹, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
共焦点レーザー内視鏡による肺癌胸膜浸潤診断,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 滝沢宏光, 鳥羽博明, 松本大資, 山田亮, 鈴木恵美, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下手術導入における3D臓器モデルを用いた術前トレーニング,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 高嶋美佳, 鳥羽博明, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
食道気管支瘻を伴った食道癌による気管分岐部狭窄に対し気道ステント留置が有効であった1例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 吉田光輝, 岩田貴, 赤池雅史, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章, 鶴尾吉宏 :
《ワークショップ》外科手術教育の当院における取り組み,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 山田亮, 吉田光輝, 河北直也, 鈴木恵美, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌との鑑別に苦慮した，気管内過誤腫による閉塞性肺炎の一切除例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 鈴木恵美, 河北直也, 山田亮, 松本大資, 高嶋美佳, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
高齢者気管支脂肪腫に対し気管支鏡下に切除を行った一例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 鳥羽博明, 六田暉朗, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡検査用局所麻酔薬噴霧カテーテルスプレーの有用性-第2報-,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
触知困難小型肺病変に対するコイルと色素を用いたマーキング法,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTを用いた極細径気管支鏡下生検の現状と展望,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 坪井光弘, 青山万理子, 滝沢宏光, 丹黒章 :
悪性を疑う濾胞性腫瘍の検査所見の検討,
第31回日本内分泌外科学会総会, 2019年6月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
甲状腺原発悪性リンパ腫の診断における穿刺吸引細胞診の有用性についての検討,
第31回日本内分泌外科学会総会, 2019年6月. 高嶋美佳, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科における前縦隔腫瘍に対する手術アプローチ法の検討,
第62回関西胸部外科学会学術集会, 2019年6月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
胸腺手術手技の3D CT画像による評価-胸骨正中切開と剣状突起下アプローチの比較検討-,
第62回関西胸部外科学会学術集会, 2019年6月. 鈴木恵美, 吉田卓弘, 西野豪志, 井上聖也, 山田亮, 笹聡一郎, 青山万理子, 森本雅美, 兼松美幸, 武知浩和, 丹黒章 :
食道閉鎖から50年間耐え抜いた後に食道切除再建を行い経口摂取可能となった1例,
第62回関西胸部外科学会学術集会, 2019年6月. 高嶋美佳, 鳥羽博明, 笹聡一郎, 松本大資, 井上聖也, 河北直也, 澤田徹, 西野豪志, 坪井光弘, 川上行奎, 吉田卓弘, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
食道気管支瘻を伴った食道癌による気管分岐部狭窄に対し気道ステント留置が有効であった1例,
第62回関西胸部外科学会学術集会, 2019年6月. 河北直也, 滝沢宏光, 近藤和也, 鈴木恵美, 山田亮, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 丹黒章 :
横隔膜交通症に対するICG蛍光ガイド下手術の2例,
第62回関西胸部外科学会学術集会, 2019年6月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章 :
食道胃接合部癌におけるCTリンパ管造影を用いた至適リンパ節郭清,
第62回関西胸部外科学会学術集会, 2019年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
縦隔鏡下食道癌根治術における縦隔リンパ節郭清の工夫-縦隔鏡操作と経裂孔操作の連携-,
第62回関西胸部外科学会学術集会, 2019年6月. 笹聡一郎, 井上聖也, 鈴木恵美, 山田亮, 森本雅美, 兼松美幸, 西野豪志, 吉田卓弘, 武知浩和, 丹黒章 :
術後乳糜瘻に対する鼠径リンパ節アプローチによるリンパ管造影の有用性の検討,
第73回日本食道学会学術集会, 2019年6月. 井上聖也, 吉田卓弘, 西野豪志, 鈴木恵美, 山田亮, 笹聡一郎, 青山万理子, 森本雅美, 武知浩和, 丹黒章 :
胸骨気管間距離(STD)に基づく再建法の工夫,
第73回日本食道学会学術集会, 2019年6月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 丹黒章 :
《口演1》食道胃接合部癌における原発巣からのリンパルートと至適リンパ節郭清,
第73回日本食道学会学術集会, 2019年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
《ワークショップ》超音波気管支鏡による食道癌の気管・気管支浸潤の診断法についての研究,
第73回日本食道学会学術集会, 2019年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
縦隔鏡下食道癌根治術における縦隔鏡操作と経裂孔操作の連携による縦隔リンパ節郭清の工夫,
第73回手術手技研究会, 2019年5月. 滝沢宏光, 鳥羽博明, 松本大資, 山田亮, 鈴木恵美, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下手術導入における3D臓器モデルとスキルシミュレータの活用,
第36回日本呼吸器外科学会総会, 2019年5月. 鈴木恵美, 吉田光輝, 東桃代, 山田亮, 松本大資, 高嶋美佳, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科からみた結核スクリーニング-T-SPOT検査は有用であるか-,
第36回日本呼吸器外科学会総会, 2019年5月. 高嶋美佳, 鳥羽博明, 監﨑孝一郎, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腔内洗浄細胞診陽性Ⅰ期肺癌に対する術後化学療法の可能性,
第36回日本呼吸器外科学会総会, 2019年5月. 澤田徹, 近藤和也, 松井尚子, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 丹黒章 :
重症筋無力症に対する拡大胸腺摘出術の有効性について,
第36回日本呼吸器外科学会総会, 2019年5月. 鳥羽博明, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変に対する気管支鏡下コイルマーキングを用いたimage-guided VATS,
第36回日本呼吸器外科学会総会, 2019年5月. 河北直也, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
遷延性肺瘻の予測スコアは治療介入時期決定に有用である-Prospective study-,
第36回日本呼吸器外科学会総会, 2019年5月. 坪井光弘, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
転移性肺腫瘍に対する解剖学的肺切除の役割,
第36回日本呼吸器外科学会総会, 2019年5月. 松本大資, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
腎細胞癌肺転移症例に対する集学的治療としての手術療法の意義,
第36回日本呼吸器外科学会総会, 2019年5月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
残存脂肪組織量から拡大胸腺摘出術を考える,
第36回日本呼吸器外科学会総会, 2019年5月. 吉田卓弘, 西野豪志, 井上聖也, 後藤正和, 坪井光弘, 青山万理子, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章, 金山博臣, 鶴尾吉宏 :
《CST推進委員会・厚生労働班会議合同企画》未固定カダバーによる教育と研究徳島大学の取り組み,
第119回日本外科学会定期学術集会, 2019年4月. 河北直也, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》遷延性肺瘻の予測スコアは治療介入時期決定に有用である,
第119回日本外科学会定期学術集会, 2019年4月. 井上聖也, 吉田卓弘, 西野豪志, 鈴木恵美, 山田亮, 笹聡一郎, 青山万理子, 森本雅美, 兼松美幸, 後藤正和, 武知浩和, 丹黒章, 樫地彩実, 濵田康弘 :
《ワークショップ》当院における多職種介入による食道癌集学的治療のアウトカム,
第119回日本外科学会定期学術集会, 2019年4月. 丹黒章, 吉田卓弘, 西野豪志, 井上聖也 :
《パネルディスカッション》食道癌術後合併症対策のための様々な試み,
第119回日本外科学会定期学術集会, 2019年4月. 西野豪志, 吉田卓弘, 井上聖也, 兼松美幸, 後藤正和, 鈴木恵美, 山田亮, 笹聡一郎, 武知浩和, 清家純一, 丹黒章 :
《シンポジウム》気管浸潤を伴う進行食道癌に対する治療戦略-R0手術を達成するための術前診断と手術手技の工夫-,
第119回日本外科学会定期学術集会, 2019年4月. 坪井光弘, 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《ミニシンポジウム》肺野末梢病変に対するCone-beam CTを用いた極細径気管支鏡下肺生検,
第59回日本呼吸器学会学術講演会, 2019年4月. 鳥羽博明, 六田暉朗, 監﨑孝一郎, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡検査用新型局所麻酔薬噴霧カテーテルスプレーの使用経験,
第27回日本呼吸器内視鏡学会中国四国支部会, 2018年12月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
再発胸腺上皮性腫瘍に対する手術療法の意義,
第59回日本肺癌学会総会, 2018年11月. 吉田光輝, 小川博久, 湯浅康弘, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
CTでの充実径計測は妥当か，上皮内癌，微小浸潤癌におけるVINCENT3D解析と病理像の比較,
第59回日本肺癌学会総会, 2018年11月. 坪井光弘, 近藤和也, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《口演》腺癌におけるGAD1発現の臨床的意義,
第59回日本肺癌学会総会, 2018年11月. 副島志帆, ウシマンヌリアミナ, 近藤和也, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《口演》胸腺上皮性腫瘍の悪性度とGAD1(glutamic acid decarboxylase1)遺伝子のDNAメチル化の関係,
第59回日本肺癌学会総会, 2018年11月. 澤田徹, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《口演》肺癌における胸膜浸潤診断の予測因子の検討,
第59回日本肺癌学会総会, 2018年11月. 笹聡一郎, 井上聖也, 鈴木恵美, 山田亮, 森本雅美, 兼松美幸, 西野豪志, 武知浩和, 吉田卓弘, 丹黒章 :
術後乳糜瘻に対する鼠径リンパ節アプローチによるリンパ管造影の有用性,
第80回日本臨床外科学会総会, 2018年11月. 高嶋美佳, 鳥羽博明, 鈴木恵美, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科における胸腔内洗浄細胞診陽性症例での再発例の検討,
第80回日本臨床外科学会総会, 2018年11月. 鈴木恵美, 高嶋美佳, 鳥羽博明, 吉田卓弘, 松本大資, 森本雅美, 河北直也, 澤田徹, 坪井光弘, 武知浩和, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
放射線皮膚潰瘍・胸骨骨髄炎に対し広汎骨性胸郭切除を行った乳癌再発の1例,
第80回日本臨床外科学会総会, 2018年11月. 西野豪志, 吉田卓弘, 鈴木恵美, 山田亮, 笹聡一郎, 兼松美幸, 井上聖也, 後藤正和, 武知浩和, 清家純一, 丹黒章 :
縦隔鏡下食道癌根治術を安全に導入するために∼ラーニングステップとしての縦隔鏡・胸腔鏡ハイブリッド手術∼,
第80回日本臨床外科学会総会, 2018年11月. 井上聖也, 吉田卓弘, 西野豪志, 鈴木恵美, 山田亮, 笹聡一郎, 青山万理子, 松本大資, 兼松美幸, 武知浩和, 丹黒章 :
《パネルディスカッション》食道癌治療における安全な中心静脈カテーテルは?,
第80回日本臨床外科学会総会, 2018年11月. 坪井光弘, 青山万理子, 滝沢宏光, 吉田卓弘, 吉田光輝, 丹黒章 :
《シンポジウム》内視鏡下甲状腺手術におけるCadaver training,
第80回日本臨床外科学会総会, 2018年11月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 鈴木恵美, 山田亮, 青山万理子, 池内真由美, 笹聡一郎, 森本雅美, 兼松美幸, 坪井光弘, 武知浩和, 清家純一, 丹黒章 :
《スポンサードシンポジウム:ワークショップ》食道癌術後の栄養および消化管機能回復への大建中湯の可能性,
第80回日本臨床外科学会総会, 2018年11月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《一般口演》肺癌胸膜浸潤の術中評価における我々の取り組み,
第39回日本レーザー医学会総会, 2018年11月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
《口演》FDG-PET/CTで発見された甲状腺異常集積症例の検討,
第51回日本甲状腺外科学会学術集会, 2018年10月. 坪井光弘, 青山万理子, 滝沢宏光, 丹黒章 :
《口演》内視鏡下甲状腺手術の最適化を目指して,
第51回日本甲状腺外科学会学術集会, 2018年10月. 森本雅美, 宮本容子, 吉田友紀子, 笹聡一郎, 池内真由美, 兼松美幸, 中川美砂子, 鳥羽博明, 武知浩和, 丹黒章 :
当院における遺伝性乳癌卵巣癌症候群に対する取り組みと現状,
日本人類遺伝学会第63回大会, 2018年10月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 武知浩和, 清家純一, 丹黒章 :
《シンポジウム》縦隔鏡下食道癌根治術を目指した縦隔鏡・胸腔鏡ハイブリッド食道切除術,
第71回日本胸部外科学会定期学術集会, 2018年10月. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 新沼猛, 鈴木拓, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
トリプルネガティブ乳癌におけるSALL3の高頻度なエピジェネティックな不活化機構,
第77回日本癌学会学術総会, 2018年9月. 奥村和正, 松下洋輔, 小松正人, 木村竜一朗, 吉丸哲郎, 尾野雅哉, 三好康雄, 本田純子, 笹三徳, 丹黒章, 片桐豊雅 :
トリプリネガティブ乳がんにおけるRHBDL2の役割解明と抗体創薬の可能性,
第77回日本癌学会学術総会, 2018年9月. 鈴木恵美, 吉田卓弘, 西野豪志, 井上聖也, 兼松美幸, 笹聡一郎, 山田亮, 武知浩和, 丹黒章, 岩橋衆一, 木下肇 :
重篤な大動脈弁狭窄症を合併した肝細胞癌と食道癌の同時性重複癌の1切除例,
第93回中国四国外科学会総会・第23回中国四国内視鏡外科研究会, 2018年9月. 高嶋美佳, 吉田光輝, 近藤和也, 坪井光弘, 河北直也, 澤田徹, 鈴木恵美, 山田亮, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
剣状突起下アプローチ拡大胸腺摘出術の当院における導入の経験,
第93回中国四国外科学会総会・第23回中国四国内視鏡外科研究会, 2018年9月. 武知浩和, 一宮由貴, 松岡由江, 三木幸代, 森本雅美, 鳥羽博明, 笹聡一郎, 池内真由美, 兼松美幸, 吉田卓弘, 丹黒章 :
若年乳癌患者に対する治療時における「がん看護専門看護師」を交えたチーム医療,
第15回日本乳癌学会中国四国地方会, 2018年9月. 森本雅美, 宮本容子, 吉田友紀子, 大津雅信, 池内真由美, 中川美砂子, 阿部彰子, 鳥羽博明, 武知浩和, 桑原章, 井本逸勢, 苛原稔, 丹黒章 :
当院における遺伝性腫瘍に対する取り組み∼Li-Fraumeni症候群を経験して∼,
第15回日本乳癌学会中国四国地方会, 2018年9月. 法村尚子, 紺谷桂一, 坂本晋一, 久保尊子, 橋本新一郎, 村澤千沙, 監﨑孝一郎, 安藝史典, 三浦一真, 吉澤潔, 丹黒章, 横見瀬裕保 :
乳癌における抗腫瘍剤の臨床効果予測因子の同定:薬剤標的分子の免疫組織学的発現解析,
第15回日本乳癌学会中国四国地方会, 2018年9月. 一宮由貴, 松岡由江, 三木幸代, 森本雅美, 武知浩和, 丹黒章 :
初期治療過程にある若年乳がん患者への看護支援∼がん看護専門看護師の実践を振り返って∼,
第15回日本乳癌学会中国四国地方会, 2018年9月. 鈴木恵美, 吉田光輝, 近藤和也, 山田亮, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した粘液線維肉腫の一切除例,
第59回日本呼吸器学会中国・四国地方会/第57回日本肺癌学会中国・四国支部学術集会, 2018年7月. 山田亮, 吉田光輝, 河北直也, 鈴木恵美, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌との鑑別に苦慮した，気管内過誤腫による閉塞性肺炎の一切除例,
第59回日本呼吸器学会中国・四国地方会/第57回日本肺癌学会中国・四国支部学術集会, 2018年7月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 丹黒章, 濵田康弘 :
食道癌周術期管理における新たな取り組み,
第73回日本消化器外科学会総会, 2018年7月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 武知浩和, 清家純一, 丹黒章 :
縦隔鏡下食道癌根治術を目指した縦隔鏡・胸腔鏡ハイブリッド手術,
第73回日本消化器外科学会総会, 2018年7月. 吉田卓弘, 丹黒章, 西野豪志, 後藤正和, 井上聖也 :
Novel diagnostic approach for lymph node metastasis using CT lymphography in cT1 esophageal cancer,
第73回日本消化器外科学会総会, 2018年7月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
《一般演題(口演)》縦隔内副甲状腺腺腫に対するアプローチの工夫-気縦隔法併用縦隔鏡手術について-,
第30回日本内分泌外科学会総会, 2018年6月. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 武知浩和, 清家純一, 丹黒章 :
T4食道癌に対するコンバージョン手術の成績と展望,
第72回日本食道学会学術集会, 2018年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 武知浩和, 清家純一, 丹黒章 :
縦隔鏡下食道癌根治術を目指したラーニングステップとしての縦隔鏡・胸腔鏡hybrid手術,
第72回日本食道学会学術集会, 2018年6月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 行重佐和香, 奥村和正, 武知浩和, 丹黒章 :
HER2およびEGFRの発現から見た食道癌の治療戦略(第二報),
第72回日本食道学会学術集会, 2018年6月. 藤也寸志, 北川雄光, 丹黒章, 松原久裕 :
《ワークショップ》食道癌診療ガイドライン第4版の評価と今後の方向性,
第72回日本食道学会学術集会, 2018年6月. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 武知浩和, 丹黒章 :
《ワークショップ》食道癌に対する術前化学療法を中心とした集学的治療の効果と標準化に向けた課題,
第72回日本食道学会学術集会, 2018年6月. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 武知浩和, 丹黒章 :
《一般口演》当科における縦隔鏡下食道切除術の取り組み,
第61回関西胸部外科学会学術集会, 2018年6月. 河北直也, 滝沢宏光, 吉田卓弘, 澤田徹, 井上聖也, 後藤正和, 西野豪志, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《Case Presentation Award》有茎大網弁被覆により有瘻性膿胸を回避できた右上葉管状肺葉切除の1例,
第61回関西胸部外科学会学術集会, 2018年6月. 森本雅美, 池内真由美, 中川美砂子, 武知浩和, 鳥羽博明, 吉田卓弘, 丹黒章 :
乳癌頚椎転移による脊髄圧迫症候群に対し迅速な連携によりQOLの改善が得られた1例,
第43回日本外科系連合学会学術集会, 2018年6月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 吉田卓弘, 丹黒章 :
《一般口演》肺癌術後再発例の地域連携から看取りについて-良い連携ができた1例から考える-,
第43回日本外科系連合学会学術集会, 2018年6月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 清家純一, 丹黒章 :
《ビデオシンポジウム》縦隔鏡下食道癌根治術を目指したlearning stepとしての縦隔鏡・胸腔鏡hybrid手術,
第43回日本外科系連合学会学術集会, 2018年6月. 河北直也, 滝沢宏光, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CT併用による極細径気管支鏡下肺生検の初期導入経験,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 坪井光弘, 滝沢宏光, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTガイド下肺野末梢病変の経気管支鏡診断においてCBCT signは重要である,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 澤田徹, 吉田光輝, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》気管支鏡の故障をいかに防ぐか∼我々の知るべきこと∼,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 吉田光輝, 東桃代, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》結核スクリーニングにおけるT-SPOT測定-気管支鏡検査，胸腔鏡生検の役割-,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 鳥羽博明, 六田暉朗, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》気管支鏡検査用新型局所麻酔薬噴霧カテーテルスプレーの使用経験,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《Videoセッション》Hybrid手術室で行う小型末梢肺病変に対するCone-beam CTガイド下気管支鏡下コイルマーキング,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 滝沢宏光, 河北直也, 吉田光輝, 井上聖也, 後藤正和, 西野豪志, 吉田卓弘, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
《シンポジウム》未固体遺体による高難度手術の術前シミュレーション,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 滝沢宏光, 河北直也, 澤田徹, 西野豪志, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《一般示説》微小浸潤性腺癌を術前診断するのは困難である,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 澤田徹, 近藤和也, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般示説》重症筋無力症の拡大胸腺摘出術の長期効果と周術期管理,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 坪井光弘, 近藤和也, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般口演》根治手術後の胸腺癌の再発病変に対する治療,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般口演》肺葉切除後の肺静脈断端血栓とそれに起因する合併症,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 近藤和也, 副島志帆, ウシマンヌリアミナ, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《要望演題》胸腺上皮性腫瘍におけるGAD1(glutamic acid decarboxylase1)遺伝子のDNAメチル化とmRNA，蛋白発現,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 河北直也, 鳥羽博明, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《要望演題》遷延性肺瘻の予測因子に基づいた治療方針決定の可能性,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 吉田光輝, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
《要望演題》微小浸潤癌，上皮内癌の組織像と定量的CT画像解析の検討-SYNAPSE VINCENTを用いて-,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《シンポジウム》Hybrid手術室で行う小型末梢肺病変に対するCone-beamCTガイド下気管支鏡下コイルマーキング,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 森本雅美, 行重佐和香, 池内真由美, 中川美砂子, 鳥羽博明, 武知浩和, 丹黒章 :
HER2陰性ホルモン受容体陽性進行・再発乳癌に対するパクリタキセル/ベバシズマブ療法の治療成績,
第26回日本乳癌学会学術総会, 2018年5月. 武知浩和, 森本雅美, 中川美砂子, 鳥羽博明, 行重佐和香, 池内真由美, 奥村和正, 吉田卓弘, 丹黒章 :
悪性リンパ腫経過観察中に実施した腋窩リンパ節生検で発見した乳癌の1例,
第26回日本乳癌学会学術総会, 2018年5月. 池内真由美, 行重佐和香, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 鳥羽博明, 丹黒章 :
胸壁浸潤を伴う局所再発に対して切除を行った超高齢者乳癌の2例,
第26回日本乳癌学会学術総会, 2018年5月. 行重佐和香, 池内真由美, 森本雅美, 中川美砂子, 鳥羽博明, 武知浩和, 丹黒章 :
乳腺基質産生癌(matrix-producing carcinoma)の3例,
第26回日本乳癌学会学術総会, 2018年5月. 奥村和正, 三好康雄, 武知浩和, 本田純子, 笹三徳, 丹黒章, 片桐豊雅 :
《ポスター討議》トリプルネガティブ乳がんの悪性化におけるRHBDL2の役割解明,
第26回日本乳癌学会学術総会, 2018年5月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 丹黒章 :
縦隔鏡下食道癌根治術を目指したラーニングステップとしての縦隔鏡・胸腔鏡ハイブリッド手術,
第72回手術手技研究会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変に対するCone-beam CT併用気管支鏡下コイルマーキング-Hybrid手術室で全身麻酔下にすべてできる-,
第118回日本外科学会定期学術集会, 2018年4月. 滝沢宏光, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肺切除が有効である大腸癌肺転移症例の臨床病理学的背景,
第118回日本外科学会定期学術集会, 2018年4月. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 奥村和正, 行重佐和香, 鳥羽博明, 丹黒章 :
T4食道癌に対する集学的治療と課題,
第118回日本外科学会定期学術集会, 2018年4月. 橋本脩平, 西麻希, 山田静恵, 鈴木佳子, 山田苑子, 菊井聡子, 松村晃子, 山本ゆかり, 坂東左奈子, 近藤心, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章, 濵田康弘 :
当院における食道癌手術に対するNSTの取り組みと今後の展望について,
第21回日本病態栄養学会年次学術集会, 2018年1月. 青山万理子, 吉田光輝, 行重佐和香, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
後縦隔ミュラー管嚢胞の1例,
第79回日本臨床外科学会総会, 2017年11月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対してICG蛍光観察下に胸腔鏡下肺部分切除を行った1例,
第79回日本臨床外科学会総会, 2017年11月. 行重佐和香, 川上行奎, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Minute pulmonary meningothelial like nodulesの3例,
第79回日本臨床外科学会総会, 2017年11月. Moriyama Satomi, Daisuke Hinode, Masami Yoshioka, Sogawa Yuka, Denis Mayrand, Takeshi Nishino, Akira Tangoku and Daniel Grenier :
Impact of the use of Kampo medicine in patients with esophageal cancer during chemotherapy: a clinical trial,
65th Annual Meeting of the Japanese Association for Dental Research, Nov. 2017. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 宮川義仁, 本田純子, 井本逸勢, 丹黒章, 鈴木拓, 三好康雄, 笹三徳, 片桐豊雅 :
包括的なゲノム解析によるトリプルネガティブ乳癌の分子特性の解明,
日本人類遺伝学会第62回大会, 2017年11月. 森本雅美, 武知浩和, 行重佐和香, 池内真由美, 中川美砂子, 丹黒章 :
検診で指摘され得なかった腋窩副乳癌の1例,
第27回日本乳癌検診学会学術総会, 2017年11月. 中川美砂子, 行重佐和香, 池内真由美, 森本雅美, 奥村和正, 武知浩和, 鳥羽博明, 丹黒章 :
《一般口演》当院における検診発見乳癌-自覚症状の有無の観点から-,
第27回日本乳癌検診学会学術総会, 2017年11月. 森本雅美, 武知浩和, 行重佐和香, 池内真由美, 中川美砂子, 丹黒章 :
《一般口演》当院におけるステレオガイド下マンモトーム生検の検討,
第27回日本乳癌検診学会学術総会, 2017年11月. 武知浩和, 行重佐和香, 池内真由美, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 丹黒章 :
《一般口演》悪性リンパ腫の経過観察中に実施した腋窩リンパ節生検で発見した乳癌の1例,
第27回日本乳癌検診学会学術総会, 2017年11月. 行重佐和香, 森本雅美, 武知浩和, 池内真由美, 中川美砂子, 鳥羽博明, 丹黒章 :
《一般口演》妊娠中に診断された乳腺癌肉腫の1例,
第27回日本乳癌検診学会学術総会, 2017年11月. 池内真由美, 森本雅美, 武知浩和, 行重佐和香, 中川美砂子, 丹黒章 :
《一般口演》初診時の針生検で悪性所見を認めず6ヶ月後にPaget病と診断された1例,
第27回日本乳癌検診学会学術総会, 2017年11月. 武知浩和, 池内真由美, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 丹黒章 :
《一般口演》乳腺原発悪性リンパ腫の1例,
第27回日本乳癌検診学会学術総会, 2017年11月. 武知浩和, 山尾雅美, 平田有紀奈, 松本真依, 西尾進, 行重佐和香, 池内真由美, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 丹黒章 :
《一般口演》超音波検査センターとの連携で確定診断できた乳癌3例,
第27回日本乳癌検診学会学術総会, 2017年11月. 河北直也, Ali Eman, 滝沢宏光, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 丹黒章, 近藤和也 :
《渡辺洋一記念奨励賞選考対象演題》(呼吸器内視鏡)コンビームCTによる気管支鏡生検の検査精度向上,
第26回日本呼吸器内視鏡学会中国四国支部会, 2017年10月. 武知浩和, 松岡由江, 一宮由貴, 三木幸代, 青山万理子, 池内真由美, 森本雅美, 井上聖也, 後藤正和, 西野豪志, 中川美砂子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
緩和ケア認定看護師介入により治療満足度が高まった局所進行乳腺小葉癌の1例,
第55回日本癌治療学会学術集会, 2017年10月. 森本雅美, 行重佐和香, 池内真由美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章 :
当院におけるHER2陽性転移再発乳癌に対するトラスツズマブエムタンシンの治療成績,
第55回日本癌治療学会学術集会, 2017年10月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるCDH3のDNAメチル化,
第58回日本肺癌学会学術集会, 2017年10月. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 宮川義仁, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
TNBCにおける包括的なゲノム解析によるZNFタンパク質のジェネティックかつエピジェネティックな変化の同定,
第76回日本癌学会学術総会, 2017年9月. 奥村和正, 松下洋輔, 小松正人, 木村竜一朗, 吉丸哲郎, 尾野雅哉, 三好康雄, 本田純子, 笹三徳, 丹黒章, 片桐豊雅 :
《Japanese Oral Sessions》トリプルネガティブ乳がんの悪性化におけるRHBDL2の役割解明,
第76回日本癌学会学術総会, 2017年9月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
肺癌術前のリンパ節転移評価におけるPET-CT検査の診断精度,
第70回日本胸部外科学会定期学術集会, 2017年9月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般口演》凝固壊死を伴う胸腺上皮性腫瘍の検討,
第70回日本胸部外科学会定期学術集会, 2017年9月. 西脇裕記, 芥川正武, 榎本崇宏, 安野恵実子, 小中信典, 木内陽介, 丹黒章 :
多電極生体インピーダンス分布測定装置の開発,
平成29年度電気関係学会四国支部連合大会講演論文集(2017 愛媛大学), 161, 2017年9月. 板東真由, 安倍吉郎, 石田創士, 峯田一秀, 吉本聖, 武知浩和, 森本雅美, 丹黒章, 橋本一郎 :
両側乳房再建術後に乳房切除後疼痛症候群が疑われ SBI 抜去に至った一例,
第5回日本乳房オンコプラスティックサージャリー学会総会, 2017年9月. 一宮由貴, 雄西智惠美, 丹黒章 :
社会復帰課程にある若年乳がん患者の夫が認識する役割,
第14回日本乳癌学会中国四国地方会, 2017年9月. 武知浩和, 行重佐和香, 青山万理子, 池内真由美, 森本雅美, 井上聖也, 後藤正和, 西野豪志, 中川美砂子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
乳癌治療における近藤誠理論の問題点を実感した1例,
第14回日本乳癌学会中国四国地方会, 2017年9月. 行重佐和香, 森本雅美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章 :
輸血せずに集学的治療により止血せしめた薬剤抵抗性血管浸潤進行副乳癌の1例,
第14回日本乳癌学会中国四国地方会, 2017年9月. 森本雅美, 行重佐和香, 池内真由美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章 :
形成外科との協働による乳房切除後再建症例の検討,
第14回日本乳癌学会中国四国地方会, 2017年9月. 池内真由美, 森本雅美, 武知浩和, 行重佐和香, 中川美砂子, 丹黒章 :
《優秀演題セッション》乳癌術後補助化学療法中に白質脳症をきたした1例,
第14回日本乳癌学会中国四国地方会, 2017年9月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 清家純一, 丹黒章 :
食道癌治療における大建中湯，六君子湯の効果についての臨床研究,
第72回日本消化器外科学会総会, 2017年7月. 西野豪志, 吉田卓弘, 井上聖也, 武知浩和, 清家純一, 丹黒章 :
高齢者食道癌に対する縦隔鏡下食道切除術の適応と問題点,
第20回日本高齢消化器病学会総会, 2017年7月. 武知浩和, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
悪性葉状腫瘍に対して地元医療機関と連携しつつ多職種アプローチを実践した1例,
第25回日本乳癌学会学術総会, 2017年7月. 橋本脩平, 西麻希, 山田静恵, 鈴木佳子, 安井苑子, 菊井聡子, 松村晃子, 山本ゆかり, 坂東左奈子, 近藤心, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章, 濵田康弘 :
当院における食道癌手術に対するNST 活動について ∼よりよい周術期管理を目指して∼,
第42回日本外科系連合学会学術集会, 2017年6月. 梶浦耕一郎, 吉田光輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
前方後方アプローチにて摘出した胸腔内ダンベル型神経線維腫症の1例,
第42回日本外科系連合学会学術集会, 2017年6月. 藤本啓介, 河北直也, 梶浦耕一郎, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺切除術直後に急性心筋梗塞を発症した1例,
第42回日本外科系連合学会学術集会, 2017年6月. 河北直也, 藤本啓介, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 先山正二, 広瀬敏幸, 丹黒章 :
BEP療法中に発症した間質性肺炎治療後に手術を施行した2例,
第42回日本外科系連合学会学術集会, 2017年6月. 吉田光輝, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野恒作, 鶴尾吉宏 :
鏡視下手術時代の教育の開発未固定遺体を用いた胸腔鏡手術トレーニングの経験,
第42回日本外科系連合学会学術集会, 2017年6月. 澤田徹, 滝沢宏光, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
胸腔鏡下手術における3D内視鏡システムの有用性について,
第42回日本外科系連合学会学術集会, 2017年6月. 行重佐和香, 森本雅美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章, 岩本誠司, 古谷俊介, 生島仁史, 原田雅史 :
輸血せずに集学的治療により止血せしめた薬剤抵抗性血管浸潤進行副乳癌の1例,
第42回日本外科系連合学会学術集会, 2017年6月. 吉田卓弘, 西野豪志, 井上聖也, 丹黒章, 安倍吉郎, 柏木圭介, 橋本一郎, 阿部晃治 :
当院における食道再建術における他科連携手術,
第42回日本外科系連合学会学術集会, 2017年6月. 井上聖也, 吉田卓弘, 西野豪志, 藤本啓介, 西岡康平, 宮本直輝, 青山万理子, 澤田徹, 武知浩和, 丹黒章 :
《一般口演》食道癌周術期における多職種介入による回復強化,
第42回日本外科系連合学会学術集会, 2017年6月. 森本雅美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章, 柏木圭介, 橋本一郎 :
《一般口演》形成外科との協働による乳房切除後再建症例の検討,
第42回日本外科系連合学会学術集会, 2017年6月. 坪井光弘, 滝沢宏光, 青山万理子, 井上聖也, 河北直也, 澤田徹, 西野豪志, 中川美砂子, 奥村和正, 武知浩和, 鳥羽博明, 吉田卓弘, 川上行奎, 吉田光輝, 丹黒章 :
《一般口演》総頚動脈再建を行った甲状腺乳頭癌の1例,
第42回日本外科系連合学会学術集会, 2017年6月. 青山万理子, 坪井光弘, 河北直也, 滝沢宏光, 丹黒章, 東野恒作, 鶴尾吉宏 :
《一般口演》当科における未固定遺体を用いた手術トレーニングと内視鏡下甲状腺手術導入の取り組み,
第42回日本外科系連合学会学術集会, 2017年6月. 西野豪志, 吉田卓弘, 井上聖也, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 滝沢宏光, 丹黒章 :
《ワークショップ》胸部外科手術における合併症予防のためのチームのちから-医科歯科連携の成果-,
第42回日本外科系連合学会学術集会, 2017年6月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》当院における肺がん術後連携クリニカルパス-連携不良例から今後の方向性を考える-,
第42回日本外科系連合学会学術集会, 2017年6月. 山田亮, 西野豪志, 井上聖也, 吉田卓弘, 武知浩和, 清家純一, 丹黒章 :
《Case Presemtation Award》食道癌術後1年以上を経て発症した遅発性難治性乳糜胸の1例,
第60回関西胸部外科学会学術集会, 2017年6月. 西野豪志, 吉田卓弘, 井上聖也, 武知浩和, 清家純一, 丹黒章 :
《パネルディスカッション》高齢者食道癌に対する縦隔鏡下食道切除術の適当と問題点,
第60回関西胸部外科学会学術集会, 2017年6月. 井上聖也, 吉田卓弘, 西野豪志, 宮本直輝, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 武知浩和, 丹黒章 :
縫合不全回避のための食道再建経路に関するわれわれの工夫と治療成績,
第71回日本食道学会学術集会, 2017年6月. 西岡康平, 井上聖也, 吉田卓弘, 西野豪志, 藤本啓介, 宮本直輝, 青山万理子, 澤田徹, 武知浩和, 丹黒章 :
進行食道癌と診断された食道粘膜下血腫の1例,
第71回日本食道学会学術集会, 2017年6月. 藤本啓介, 井上聖也, 吉田卓弘, 西野豪志, 宮本直輝, 西岡康平, 青山万理子, 澤田徹, 武知浩和, 丹黒章 :
食道炎による食道閉鎖を50年間耐え抜いた患者に対して食道切所再建を施行した1例,
第71回日本食道学会学術集会, 2017年6月. 西野豪志, 吉田卓弘, 井上聖也, 武知浩和, 清家純一, 丹黒章 :
超音波気管支鏡による食道癌の気管膜様部浸潤の診断法-Cadaver研究-,
第71回日本食道学会学術集会, 2017年6月. 森本雅美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章 :
当院における進行再発乳癌に対するエリブリンの治療成績,
第25回日本乳癌学会学術総会, 2017年6月. 宮本直輝, 吉田光輝, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
DynaCTの気管支鏡生検における可能性,
第40回日本呼吸器内視鏡学会学術集会, 2017年6月. 梶浦耕一郎, 滝沢宏光, 坪井光弘, 澤田徹, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
有瘻性膿胸に対するEWSを用いた気管支充填術,
第40回日本呼吸器内視鏡学会学術集会, 2017年6月. 吉田光輝, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科手術における血管の破格症例,
第26回日本癌病態治療研究会, 2017年6月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
肺癌術後再発の長期生存例の検討,
第26回日本癌病態治療研究会, 2017年6月. 吉田卓弘, 西野豪志, 井上聖也, 中川美砂子, 森本雅美, 奥村和正, 武知浩和, 丹黒章 :
《パネルディスカッション》食道癌における術前化学療法時代における術前化学放射線療法の役割,
第26回日本癌病態治療研究会, 2017年6月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
縦隔嚢胞性疾患における嚢胞内成分の鑑別指標となる画像診断,
第34回日本呼吸器外科学会総会, 2017年5月. 宮本直輝, 吉田光輝, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
ハイブリッド手術室を利用したVATSの経験,
第34回日本呼吸器外科学会総会, 2017年5月. 澤田徹, 坪井光弘, 宮本直輝, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Trimodality theraphyにおける治療前後のSUVmaxと治療効果の関連性の検討,
第34回日本呼吸器外科学会総会, 2017年5月. 吉田光輝, 近藤和也, 梶浦耕一郎, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
《一般口演》胸腺腫における石灰化は意義を持つのか,
第34回日本呼吸器外科学会総会, 2017年5月. 川上行奎, 青山万理子, 河北直也, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般ビデオ》S6区域切除+フラップ気管支形成術を行った気管支内過誤腫の一例,
第34回日本呼吸器外科学会総会, 2017年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《要望ビデオ》多発GGO病変に対して気管支鏡下コイルマーキングでS1側のマージンを担保した完全鏡視下右S2区域切除,
第34回日本呼吸器外科学会総会, 2017年5月. 坪井光弘, 吉田光輝, 河北直也, 梶浦耕一郎, 澤田徹, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章, 須田隆 :
《要望演題》当科における剣状突起下切開単孔式胸腺摘出導入の取り組み-未固定遺体を用いた手術トレーニングについて-,
第34回日本呼吸器外科学会総会, 2017年5月. 河北直也, 鳥羽博明, 広瀬敏幸, 松本大資, 澤田徹, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《シンポジウム》pStageⅠ肺腺癌の治療戦略-簡便な3因子を用いた予後の層別化と術後補助療法の可能性-,
第34回日本呼吸器外科学会総会, 2017年5月. 吉田卓弘, 西野豪志, 井上聖也, 青山万理子, 澤田徹, 宮本直輝, 西岡康平, 藤本啓介, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章 :
術前化学療法後に根治術が施行された進行食道癌におけるpN0の意義,
第117回日本外科学会定期学術集会, 2017年4月. 西野豪志, 吉田卓弘, 藤本啓介, 西岡康平, 宮本直輝, 青山万理子, 森本雅美, 井上聖也, 澤田徹, 河北直也, 中川美砂子, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
《ワークショップ》食道癌手術における再建経路選択の工夫-胸骨気管間距離による経路選択-,
第117回日本外科学会定期学術集会, 2017年4月. 吉田光輝, 滝沢宏光, 吉田卓弘, 坪井光弘, 河北直也, 澤田徹, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野耕作, 鶴尾吉宏 :
《考える外科学》未固定遺体とのシミュレーションを用いた新たな実践型内視鏡下低侵襲手術トレーニングプログラムの構築,
第117回日本外科学会定期学術集会, 2017年4月. 澤田徹, 滝沢宏光, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
胸腔鏡下手術における3D内視鏡システムの有用性について,
第56回日本呼吸器学会中国・四国地方会/第25回日本呼吸器内視鏡学会中国四国支部会, 2016年12月. 梶浦耕一郎, 近藤和也, 三好孝典, 松本大資, 中川靖士, 石倉久嗣, 松岡永, 監﨑孝一郎, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
胸膜播種を伴う胸腺上皮性腫瘍の検討,
第57回日本肺癌学会総会, 2016年12月. 宮本直輝, 吉田光輝, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
右上葉区域肺静脈(V2)の分岐走行異常の検討,
第57回日本肺癌学会総会, 2016年12月. 澤田徹, 鳥羽博明, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺上皮性腫瘍におけるFDG-PET/CTの有用性∼SUVmax値はRFSの予測因子になるか?,
第57回日本肺癌学会総会, 2016年12月. 河北直也, 鳥羽博明, 澤田徹, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》根治切除を行ったpStageⅠ肺腺癌の予後因子による層別化,
第57回日本肺癌学会総会, 2016年12月. 吉田卓弘, 丹黒章, 西野豪志, 井上聖也 :
Mediastinoscopy-assisted left recurrent nerve lymph node dissection in cadaver models,
第29回日本内視鏡外科学会総会, 2016年12月. 丹黒章 :
《ワークショップ》内視鏡を用いた乳癌低侵襲手術,
第29回日本内視鏡外科学会総会, 2016年12月. 行重佐和香, 武知浩和, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 西岡康平, 藤本啓介, 宮本直輝, 青山万理子, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章 :
地域連携を依頼しながら症状緩和に努めた乳腺悪性葉状腫瘍の1例,
第78回日本臨床外科学会総会, 2016年11月. 宮本直輝, 梶浦耕一郎, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
同一病変内に放線菌症とAdenocarcinomaを併発した一例,
第78回日本臨床外科学会総会, 2016年11月. 梶浦耕一郎, 滝沢宏光, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Thopaz®によるドレーン管理中に起こった右肺全摘術後の皮下気腫の1例,
第78回日本臨床外科学会総会, 2016年11月. 西岡康平, 鳥羽博明, 藤本啓介, 宮本直輝, 河北直也, 澤田徹, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
再生不良性貧血を合併した胸腺腫に対して，術前大量ステロイド療法後に手術を施行し，pCRが得られた1例,
第78回日本臨床外科学会総会, 2016年11月. 河北直也, 滝沢宏光, 梶浦耕一郎, 藤本啓介, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肝性胸水に対する胸腔鏡下横隔膜修復術の1例-術中気腹法およびICG蛍光法併用の試み-,
第78回日本臨床外科学会総会, 2016年11月. 藤本啓介, 井上聖也, 西岡康平, 青山万理子, 西野豪志, 奥村和正, 武知浩和, 吉田卓弘, 丹黒章 :
当科における食道内分泌細胞癌症例の検討,
第78回日本臨床外科学会総会, 2016年11月. 青山万理子, 井上聖也, 藤本啓介, 西岡康平, 西野豪志, 奥村和正, 武知浩和, 吉田卓弘, 丹黒章 :
当科における食道癌肉腫症例の検討,
第78回日本臨床外科学会総会, 2016年11月. 井上聖也, 吉田卓弘, 西野豪志, 藤本啓介, 西岡康平, 青山万理子, 奥村和正, 武知浩和, 丹黒章 :
縫合不全ゼロを目指した胸骨気管距離(STD)からみた再建経路の選択法,
第78回日本臨床外科学会総会, 2016年11月. 本田純子, 笹三徳, 高橋雅子, 廣瀬千恵子, 生島葉子, 井上光郎, 三木仁司, 鎌田正晴, 濱田信一, 坂東良美, 丹黒章, 森本忠興 :
マンモグラフィ所見の変化からみた乳癌の悪性度,
第26回日本乳癌検診学会学術総会, 2016年11月. 坪井光弘, 滝沢宏光, 西岡康平, 藤本啓介, 宮本直輝, 青山万理子, 澤田徹, 河北直也, 丹黒章 :
レンバチニブ投与後に手術を行った局所進行甲状腺乳頭癌の1例,
第49回日本甲状腺外科学会学術集会, 2016年10月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
甲状腺全摘後にBasedow病を発症した甲状腺乳頭癌再発の1例,
第49回日本甲状腺外科学会学術集会, 2016年10月. 丹黒章, 北川雄光, 松原久裕 :
《シンポジウム》食道癌診療ガイドラインの目指すもの食道癌診断・治療ガイドラインアウトカムの検証,
第54回日本癌治療学会学術集会, 2016年10月. 奥村和正, 小松正人, 木村竜一朗, 尾野雅哉, 吉丸哲郎, 松下洋輔, 三好康雄, 本田純子, 笹三徳, 丹黒章, 片桐豊雅 :
トリプルネガティブ乳癌で高発現が認められるTNRHP1の発現亢進は癌の悪性度と相関する,
第75回日本癌学会学術総会, 2016年10月. 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 宮川義仁, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
全エキソーム解析によるトリプルネガティブ乳癌の分子特性の解明,
第75回日本癌学会学術総会, 2016年10月. 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 丹黒章 :
進行・再発乳癌に対するS-1+nab-パクリタキセル併用化学療法の至適用量の検討(第Ⅰ相試験)中間報告,
第13回日本乳癌学会中国四国地方会, 2016年10月. 武知浩和, 松岡由江, 秋月佐代, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 青山万理子, 井上聖也, 西野豪志, 吉田卓弘, 丹黒章 :
積極加療中止時期決定において乳腺治療担当医と緩和医療担当医の両面での葛藤を経験した1例,
第13回日本乳癌学会中国四国地方会, 2016年10月. 青山万理子, 吉田卓弘, 西野豪志, 井上聖也, 西岡康平, 藤本啓介, 宮本直輝, 澤田徹, 丹黒章 :
肝硬変合併食道癌の治療戦略,
第69回日本胸部外科学会定期学術集会, 2016年9月. 梶浦耕一郎, 近藤和也, 澤田徹, 坪井光弘, 河北直也, 川上行奎, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺腫瘍におけるRASSF1のDNAメチル化の検討,
第69回日本胸部外科学会定期学術集会, 2016年9月. 吉田光輝, 近藤和也, 中川靖士, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
《一般口演》胸腺腫非合併重症筋無力症患者の術前3D画像評価-拡大胸腺摘出術後の予後予測は可能か-,
第69回日本胸部外科学会定期学術集会, 2016年9月. 坪井光弘, 滝沢宏光, 河北直也, 澤田徹, 西野豪志, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《一般口演》疾患特性に応じた続発性気胸に対する治療戦略,
第69回日本胸部外科学会定期学術集会, 2016年9月. 藤本啓介, 坪井光弘, 西岡康平, 宮本直輝, 青山万理子, 滝沢宏光, 丹黒章 :
低分化成分を伴った甲状腺濾胞癌未分化転化の1例,
第91回中国四国外科学会総会・第21回中国四国内視鏡外科研究会, 2016年9月. 宮本直輝, 河北直也, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 先山正二, 丹黒章 :
《後期研修医セッション:呼吸器1》FDG-PET/CT陽性を呈した肺原発benign perivascular epithelioid cell tumorの一例,
第91回中国四国外科学会総会・第21回中国四国内視鏡外科研究会, 2016年9月. 井上聖也, 吉田卓弘, 藤本啓介, 乾友浩, 髙杉遥, 西野豪志, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
胃切除後の食道再建の検討,
第71回日本消化器外科学会総会, 2016年7月. 西野豪志, 吉田卓弘, 井上聖也, 髙杉遥, 松本大資, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
食道癌治療における漢方薬(大建中湯，六君子湯)の効果についての臨床試験,
第71回日本消化器外科学会総会, 2016年7月. 髙杉遥, 吉田卓弘, 井上聖也, 西野豪志, 乾友浩, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
食道気管支瘻に対する再建結腸に発生した進行結腸癌の1切除例,
第71回日本消化器外科学会総会, 2016年7月. 吉田卓弘, 丹黒章, 西野豪志, 井上聖也, 髙杉遥, 乾友浩, 松本大資, 奥村和正, 武知浩和, 清家純一 :
術前CTリンパ管造影を用いた食道癌におけるセンチネルリンパ節・ナビゲーション・サージェリー,
第71回日本消化器外科学会総会, 2016年7月. 井上聖也, 吉田卓弘, 西野豪志, 乾友浩, 髙杉遥, 松本大資, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
HER2およびEGFRの発現から見た進行食道癌の治療戦略,
第70回日本食道学会学術集会, 2016年7月. 吉田卓弘, 西野豪志, 井上聖也, 髙杉遥, 乾友浩, 森本雅美, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
《Special Forum》当院における食道切除術後の逆流性食道炎の現状,
第70回日本食道学会学術集会, 2016年7月. 吉田卓弘, 丹黒章, 西野豪志, 井上聖也, 髙杉遥, 乾友浩, 森本雅美, 奥村和正, 武知浩和, 清家純一 :
《Video Forum》Poor risk食道癌患者に対する縦隔鏡下食道切除術,
第70回日本食道学会学術集会, 2016年7月. 梶浦耕一郎, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
EWSによる気管支充填術の有用性評価,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 松本大資, 滝沢宏光, 乾友浩, 髙杉遥, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 先山正二, 丹黒章 :
肺癌術後に気管支鏡的処置を要した症例の検討,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 河北直也, 鳥羽博明, 先山正二, 松本大資, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
選択的肺葉ブロックが有用であった肺切除術の2例,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
人工気胸を併用した胸腔鏡下胸腺部分切除の1例,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 田所由紀子, 丹黒章, 井本逸勢 :
当院における遺伝性乳がん卵巣がん症候群に対する取り組みと現状,
第24回日本乳癌学会学術総会, 2016年6月. 西岡康平, 吉田卓弘, 西野豪志, 井上聖也, 宮本直輝, 藤本啓介, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章 :
食道良性疾患における食道運動機能評価の有用性,
第41回日本外科系連合学会学術集会, 2016年6月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
未確診肺結節のVATS切除における肺結核感染予防体制の構築,
第41回日本外科系連合学会学術集会, 2016年6月. 松本大資, 先山正二, 乾友浩, 高杉遥, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科で経験した縦隔胚細胞腫瘍切除例の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 梶浦耕一郎, 近藤和也, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺上皮性腫瘍の新TNM分類の妥当性,
第33回日本呼吸器外科学会総会, 2016年5月. 河北直也, 滝沢宏光, 川上行奎, 乾友浩, 髙杉遥, 松本大資, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 近藤和也, 先山正二, 丹黒章 :
肝細胞癌肺転移における術中ICG蛍光観察の意義,
第33回日本呼吸器外科学会総会, 2016年5月. 川上行奎, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
原発性肺癌術後の胸腔内リンパ節再発例の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 坪井光弘, 滝沢宏光, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
非小細胞肺癌における胸膜浸潤とskipリンパ節転移の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Ⅰ期非小細胞肺癌に対する消極的部分切除,
第33回日本呼吸器外科学会総会, 2016年5月. 滝沢宏光, 梶浦耕一郎, 坪井光弘, 鳥羽博明, 松本大資, 河北直也, 西野豪志, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
術前CTリンパ管造影による肺癌センチネルリンパ節同定,
第33回日本呼吸器外科学会総会, 2016年5月. 先山正二, 梶浦耕一郎, 乾友浩, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
分葉不全部を右S6からS2に広がる非浸潤肺癌に対して完全胸腔鏡下にS6+S2区域切除を施行した一例,
第33回日本呼吸器外科学会総会, 2016年5月. 西野豪志, 吉田卓弘, 井上聖也, 武知浩和, 清家純一, 丹黒章 :
T4食道癌に対する放射線療法を温存したDocetaxel/5-FU/CDDPによるinduction chemotherapyの有効性,
第102回日本消化器病学会総会, 2016年4月. 井上聖也, 吉田卓弘, 西野豪志, 乾友浩, 髙杉遥, 松本大資, 奥村和正, 武知浩和, 丹黒章 :
cStageⅣ食道癌における予後予測因子の検討,
第116回日本外科学会定期学術集会, 2016年4月. 西野豪志, 吉田卓弘, 井上聖也, 乾友浩, 髙杉遥, 松本大資, 武知浩和, 清家純一, 丹黒章 :
T4食道癌に対する治療戦略-放射線療法を温存したDocetaxel/5-FU/CDDPによるinduction chemotherapyの有効性,
第116回日本外科学会定期学術集会, 2016年4月. 吉田卓弘, 西野豪志, 井上聖也, 乾友浩, 髙杉遥, 松本大資, 奥村和正, 武知浩和, 丹黒章 :
食道胃接合部癌に対する術前CT lymphographyの有用性,
第116回日本外科学会定期学術集会, 2016年4月. 梶浦耕一郎, 近藤和也, 坪井光弘, 鳥羽博明, 滝沢宏光, 川上行奎, 先山正二, 丹黒章 :
胸腺神経内分泌腫瘍におけるRASSF1のDNAメチル化,
第35回日本胸腺研究会, 2016年2月. 坪井光弘, 近藤和也, 梶浦耕一郎, 乾友浩, 髙杉遥, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
PET-CTで広汎にFDG陽性リンパ節を伴ったリンパ濾胞性胸腺過形成の1例,
第35回日本胸腺研究会, 2016年2月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
繰り返す喀血に対して極細径気管支鏡で確認できた気管支動脈瘤の1例,
第24回日本呼吸器内視鏡学会中国四国支部会, 2015年12月. 髙杉遥, 井上聖也, 吉田卓弘, 乾友浩, 松本大資, 西野豪志, 古北由仁, 武知浩和, 清家純一, 丹黒章, 阿部吉郎, 山崎裕行, 佐々木健介, 柏木圭介, 橋本一郎 :
二度の再建臓器の壊死にて治療に難渋した食道癌の1例,
第77回日本臨床外科学会総会, 2015年11月. 西野豪志, 吉田卓弘, 滝沢宏光, 乾友浩, 髙杉遥, 松本大資, 井上聖也, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
胸部外科領域における周術期口腔機能管理の術後肺炎予防効果,
第77回日本臨床外科学会総会, 2015年11月. 梶浦耕一郎, 先山正二, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌手術症例の術前予後予測因子としてのmGPSとNLRの検討,
第56回日本肺癌学会総会, 2015年11月. 松本大資, 川上行奎, 滝沢宏光, 近藤和也, 乾友浩, 髙杉遥, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 先山正二, 丹黒章 :
肺葉切除22年後に胸壁転移を来したALK遺伝子変異陽性肺癌の1例,
第56回日本肺癌学会総会, 2015年11月. 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
進行肺癌に対する術前化学放射線療法の検討,
第56回日本肺癌学会総会, 2015年11月. 河北直也, 先山正二, 坪井光弘, 乾友浩, 髙杉遥, 松本大資, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》転移性肺腫瘍に対する完全胸腔鏡下S7区域切除術の1例,
第56回日本肺癌学会総会, 2015年11月. 滝沢宏光, 近藤和也, 乾友浩, 髙杉遥, 松本大資, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 先山正二, 丹黒章 :
《口演》胸膜の自家蛍光減弱は肺癌の浸潤性を反映する,
第56回日本肺癌学会総会, 2015年11月. Takahiro Yoshida, Takeshi Nishino, 井上聖也, 松本大資, Hirokazu Takechi, 藤原聡史, Yoshihito Furukita, 湯浅康弘, Jun-ichi Seike and Akira Tangoku :
Rational approach for esophago-gastric junctional carcinomas using preoperative CT lymphography,
Oct. 2015. 坪井光弘, 滝沢宏光, 乾友浩, 髙杉遥, 丹黒章 :
妊娠を機に増大した甲状腺低分化癌の1例,
第48回日本甲状腺外科学会学術集会, 2015年10月. 森本雅美, 中川美砂子, 鳥羽博明, 武知浩和, 田所由紀子, 丹黒章 :
当科における高齢者乳癌手術症例の検討,
第53回日本癌治療学会学術集会, 2015年10月. 西野豪志, 滝沢宏光, 乾友浩, 髙杉遥, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
周術期口腔機能管理の肺癌術後肺炎予防効果についての検討,
第68回日本胸部外科学会定期学術集会, 2015年10月. 西野豪志, 吉田卓弘, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
気管・気管支浸潤を伴う進行食道癌の診断における問題点と工夫,
第23回日本消化器関連学会週間, 2015年10月. 山尾雅美, 西尾進, 平田有紀奈, 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 山田博胤, 佐田政隆, 丹黒章 :
超音波検査による乳癌化学療法の効果予測,
第35回日本乳腺甲状腺超音波医学会, 2015年9月. 一宮由貴, 田所由紀子, 中原佳子, 松岡由江, 谷奈積, 川口博美, 森本雅美, 中川美砂子, 武知浩和, 小川美佳, 森玲子, 加藤真介, 丹黒章 :
当院の乳癌チーム医療における外来看護師の取り組みと今後の課題,
第12回日本乳癌学会中国四国地方会, 2015年9月. 谷奈積, 川口博美, 一宮由貴, 松岡由江, 中原佳子, 森玲子, 小川美佳, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 加藤真介, 丹黒章 :
乳癌チーム医療における病棟看護師の役割と今後の課題,
第12回日本乳癌学会中国四国地方会, 2015年9月. 中原佳子, 田所由紀子, 一宮由貴, 松岡由江, 森本雅美, 中川美砂子, 武知浩和, 小川美佳, 森玲子, 加藤真介, 丹黒章 :
リンパ浮腫予防指導を含めた当院での乳がん周術期患者への関わり∼多職種連携を通じて∼,
第12回日本乳癌学会中国四国地方会, 2015年9月. 田所由紀子, 森本雅美, 中川美砂子, 鳥羽博明, 武知浩和, 丹黒章 :
県下統一パス「患者手帳」を用いた乳癌術後病診連携の推進,
第12回日本乳癌学会中国四国地方会, 2015年9月. 鳥羽博明, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
乳癌治療経過中に発見された肺腫瘤の診断,
第12回日本乳癌学会中国四国地方会, 2015年9月. 髙杉遥, 乾友浩, 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 吉田卓弘, 田所由紀子, 丹黒章 :
副乳癌術後に胃癌が発見され病理学的に原発か転移か苦慮した1例,
第12回日本乳癌学会中国四国地方会, 2015年9月. 行重佐和香, 乾友浩, 髙杉遥, 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 吉田卓弘, 田所由紀子, 丹黒章 :
乳腺腺様嚢胞癌の2例,
第12回日本乳癌学会中国四国地方会, 2015年9月. 山田亮, 乾友浩, 髙杉遥, 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 吉田卓弘, 田所由紀子, 丹黒章 :
浸潤性乳管癌と術前診断された乳腺腺筋上皮腫の1例,
第12回日本乳癌学会中国四国地方会, 2015年9月. 乾友浩, 髙杉遥, 森本雅美, 中川美砂子, 武知浩和, 鳥羽博明, 吉田卓弘, 田所由紀子, 丹黒章 :
乳癌術後肺転移に原発性肺癌を合併した1例,
第12回日本乳癌学会中国四国地方会, 2015年9月. 武知浩和, 森本雅美, 西野豪志, 中川美砂子, 鳥羽博明, 吉田卓弘, 川上行奎, 滝沢宏光, 田所由紀子, 丹黒章 :
乳癌脳転移に対して全脳照射実施後に認知機能低下をきたした2例,
第12回日本乳癌学会中国四国地方会, 2015年9月. 三木幸代, 山口美代子, 丹黒章 :
外来化学療法室における過敏症出現減少に向けた取り組み,
第12回日本乳癌学会中国四国地方会, 2015年9月. 吉田卓弘, 丹黒章, 奥村和正, 中川美砂子, 森本雅美, 武知浩和, 田所由紀子 :
α線を用いたHER-2標的治療の乳管内アプローチの試み,
第12回日本乳癌学会中国四国地方会, 2015年9月. 乾友浩, 吉田卓弘, 西野豪志, 井上聖也, 松本大資, 髙杉遥, 武知浩和, 丹黒章 :
術前化学療法後に根治術を施行しえた高齢者胸部食道癌の1例,
第90回中国四国外科学会総会, 2015年9月. 髙杉遥, 鳥羽博明, 先山正二, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫再発5年後という晩期に赤芽球癆を発症し，シクロスポリンにて症状の改善を認めた1例,
第90回中国四国外科学会総会, 2015年9月. 古北由仁, 吉田卓弘, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
《企画関連口演》根治切除を目指したcT4食道癌に対する治療戦略,
第70回日本消化器外科学会総会, 2015年7月. 吉田卓弘, 古北由仁, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
《一般演題(ミニオーラル)》当院における食道切除術後有茎小腸による食道再建術-胃切除の既往の有無による比較検討-,
第70回日本消化器外科学会総会, 2015年7月. 西野豪志, 吉田卓弘, 坂本晋一, 住友弘幸, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
《ワークショップ》cStageⅡ/Ⅲ食道癌に対する治療戦略-術前weekly Docetaxel+low dose FP療法の有効性-,
第70回日本消化器外科学会総会, 2015年7月. 武知浩和, 森本雅美, 中川美砂子, 田所由紀子, 丹黒章 :
肺癌と重複した両側乳癌1切除例,
第23回日本乳癌学会学術総会, 2015年7月. 一宮由貴, 松岡由江, 中原佳子, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
当院でのリンパ浮腫予防指導∼多職種連携における看護師の役割と集団指導の効果∼,
第23回日本乳癌学会学術総会, 2015年7月. 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 兼松美幸, 高橋雅子, 笹三徳, 丹黒章 :
Overdiagnosi Low grade DCISを予測する画像所見に関する検討,
第23回日本乳癌学会学術総会, 2015年7月. 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 日野直樹, 丹黒章 :
完遂率を高め寛解率向上をめざした術前化学療法(S-1+Docetaxel逐次療法),
第23回日本乳癌学会学術総会, 2015年7月. 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 平田有紀奈, 山尾雅美, 西尾進, 丹黒章 :
CTリンパ管造影(CTLG)とVolume Navigationシステムを用いたセンチネルリンパ節生検,
第23回日本乳癌学会学術総会, 2015年7月. 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 湊拓也, 清家純一, 丹黒章 :
当科における食道癌狭窄・穿孔の治療-バイパス手術とステント挿入-,
第69回日本食道学会学術集会, 2015年7月. 古北由仁, 吉田卓弘, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
食道癌における術前化学療法と周術期管理のテーラメード化に向けて,
第69回日本食道学会学術集会, 2015年7月. 古北由仁, 吉田卓弘, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
食道癌術後の度重なる再建臓器の虚血障害で難渋した1例,
第69回日本食道学会学術集会, 2015年7月. 西野豪志, 吉田卓弘, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
気管・気管支浸潤を伴う進行食道癌の治療成績-正確な浸潤診断のために-,
第69回日本食道学会学術集会, 2015年7月. 武知浩和, 森本雅美, 西野豪志, 中川美砂子, 古北由仁, 吉田卓弘, 田所由紀子, 丹黒章 :
乳癌脳転移に対して全脳照射施行後に認知機能低下をきたし方針決定に難渋した1例,
第20回日本緩和医療学会学術大会, 2015年6月. 一宮由貴, 田所由紀子, 中原佳子, 松岡由江, 森本雅美, 中川美砂子, 武知浩和, 柴山純子, 加藤真介, 丹黒章 :
当院の乳癌チーム医療における取り組みと今後の課題∼外来看護師の立場からの検討∼,
第40回日本外科系連合学会学術集会, 2015年6月. 河北直也, 鳥羽博明, 先山正二, 三好孝典, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変の安全確実な鏡視下切除のためのCTガイド下気管支鏡下コイルマーキング,
第40回日本外科系連合学会学術集会, 2015年6月. 西野豪志, 吉田卓弘, 古北由仁, 住友弘幸, 坂本晋一, 井上聖也, 奥村和正, 武知浩和, 丹黒章 :
食道癌術後感染症に対する周術期口腔機能管理の効果に関する検討,
第40回日本外科系連合学会学術集会, 2015年6月. 吉田卓弘, 古北由仁, 西野豪志, 住友弘幸, 坂本晋一, 井上聖也, 奥村和正, 武知浩和, 丹黒章 :
食道胃接合部癌に対するセンチネルリンパ節ナビゲーションサージェリー(第2報),
第40回日本外科系連合学会学術集会, 2015年6月. 滝沢宏光, 笠松哲司, 武知浩和, 中川靖士, 坂本晋一, 住友弘幸, 坪井光弘, 丹黒章 :
《シンポジウム》甲状腺未分化癌治療を支える病診連携の重要性,
第40回日本外科系連合学会学術集会, 2015年6月. 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 丹黒章 :
当科におけるcT3-4進行食道癌に対する胸管温存食道亜全摘術の検討,
第58回関西胸部外科学会学術集会, 2015年6月. 乾友浩, 滝沢宏光, 近藤和也, 川上行奎, 坂本晋一, 住友弘幸, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 先山正二, 丹黒章 :
肺大細胞癌術後空調転移に対して手術と化学療法を行い長期生存が得られた1例,
第58回関西胸部外科学会学術集会, 2015年6月. 梶浦耕一郎, 先山正二, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気道確保を要した気管支鏡下生検による気道出血症例,
第38回日本呼吸器内視鏡学会学術集会, 2015年6月. 坂本晋一, 梶浦耕一郎, 近藤和也, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
梗塞性壊死を伴う嚢胞性胸腺腫の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 滝沢宏光, 先山正二, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 丹黒章, 近藤和也 :
大腸癌肺転移切除例の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 梶浦耕一郎, 先山正二, 坂本晋一, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
微小乳頭状パターンを伴う肺癌症例の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 住友弘幸, 鳥羽博明, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 丹黒章, 近藤和也 :
左上葉肺癌術後に生じた右難治性気胸の一例,
第32回日本呼吸器外科学会総会, 2015年5月. 川上行奎, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
左下葉肺門部肺癌に対し，下葉+舌区切除および気管支管状切除にて左肺全摘を回避できた一例,
第32回日本呼吸器外科学会総会, 2015年5月. 坪井光弘, 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
末梢小型肺癌における胸膜浸潤とFDG集積の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 鳥羽博明, 先山正二, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌術後無症候性患者でのPET/CTを用いたフォローアップ,
第32回日本呼吸器外科学会総会, 2015年5月. 西野豪志, 滝沢宏光, 住友弘幸, 坂本晋一, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
原発性肺癌における周術期口腔機能管理の有用性について,
第32回日本呼吸器外科学会総会, 2015年5月. 先山正二, 鳥羽博明, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植による肺の再生と修復,
第55回日本呼吸器学会学術講演会, 2015年4月. 中川美砂子, 坂本晋一, 住友弘幸, 森本雅美, 西野豪志, 坪井光弘, 古北由仁, 梶浦耕一郎, 武知浩和, 吉田卓弘, 中川靖士, 滝沢宏光, 田所由紀子, 先山正二, 丹黒章 :
CTリンパ管造影によるセンチネルリンパ節の転移診断,
第115回日本外科学会定期学術集会, 2015年4月. 吉田卓弘, 古北由仁, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
合理的な食道胃接合部癌の術式選択を目的としたCT lymphography,
第115回日本外科学会定期学術集会, 2015年4月. 川上行奎, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
左肺上葉切除は術後動脈血栓症の危険因子か?-各肺葉切除後，肺静脈断端血栓の有無の比較-,
第115回日本外科学会定期学術集会, 2015年4月. 兼松美幸, 笹三徳, 高橋雅子, 本田純子, 森本雅美, 中川美砂子, 田所由紀子, 吉田卓弘, 梶川愛一郎, 井本逸勢, 森谷卓也, 丹黒章 :
Ki-67を指標とした低悪性度DCISの同定とその画像所見,
第115回日本外科学会定期学術集会, 2015年4月. 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
データ解析に基づいたVATS肺葉切除術における術式工夫,
第115回日本外科学会定期学術集会, 2015年4月. 古北由仁, 吉田卓弘, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
当科における食道癌NearT4症例に対する治療戦略,
第115回日本外科学会定期学術集会, 2015年4月. 近藤和也, 中島淳, 奥村明之進, 吉野一郎, 藤井義敬, 浅村尚生, 吉田和夫, 伊達洋至, 横井香平, 先山正二, 滝沢宏光, 中川靖士, 梶浦耕一郎, 川上行奎, 丹黒章 :
胸腺上皮性腫瘍のリンパ節転移・遠隔転移に対する治療戦略,
第115回日本外科学会定期学術集会, 2015年4月. 乾友浩, 坪井光弘, 坂本晋一, 住友弘幸, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
喀血を繰り返した気管支動脈蔓状血管腫の1例,
第76回日本臨床外科学会総会, 2014年11月. 猪子未希, 坪井光弘, 坂本晋一, 住友弘幸, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
肺癌術後間質性肺炎急性増悪4例の検討,
第76回日本臨床外科学会総会, 2014年11月. 坂本晋一, 中川美砂子, 住友弘幸, 森本雅美, 武知浩和, 田所由紀子, 丹黒章 :
急性骨髄性白血病治療中に発生した乳房骨髄肉腫の1例,
第76回日本臨床外科学会総会, 2014年11月. 森下敦司, 吉田卓弘, 西野豪志, 古北由仁, 武知浩和, 丹黒章 :
食道大動脈瘻を呈した食道癌に対しTEVARで救命し得た1例,
第76回日本臨床外科学会総会, 2014年11月. 住友弘幸, 西野豪志, 坂本晋一, 古北由仁, 吉田卓弘, 武知浩和, 清家純一, 滝沢宏光, 丹黒章 :
バセドウ病に合併し，甲状腺亜全摘と食道憩室切除を同時に行ったKillian-Jamieson憩室の一例,
第76回日本臨床外科学会総会, 2014年11月. 西野豪志, 吉田卓弘, 坂本晋一, 住友弘幸, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
cStageⅡ-Ⅲ食道癌に対する術前weekly Docetaxel+low dose FP療法の治療成績,
第76回日本臨床外科学会総会, 2014年11月. 坪井光弘, 滝沢宏光, 梶浦耕一郎, 坂本晋一, 住友弘幸, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
肺区域切除におけるICG静注による新たな区域間同定法,
第76回日本臨床外科学会総会, 2014年11月. 坪井光弘, 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《パネルディスカッション》難治性気胸に対する治療戦略-気管支塞栓術と胸腔内フィブリン糊注入療法の比較-,
第76回日本臨床外科学会総会, 2014年11月. 板東孝枝, 近藤和也, 劉環, 今井芳枝, 梶浦耕一郎, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 先山正二, 鳥羽博明, 雄西智惠美, 丹黒章 :
手術療法施行した肺がん患者のpatient reported quality of life(PRQOL)及び心理状態のの評価(第2報),
第55回日本肺癌学会学術集会, 2014年11月. 滝沢宏光, 住友弘幸, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 丹黒章, 近藤和也, 森下敦司, 河北直也, 広瀬敏幸 :
自家蛍光内視鏡による胸膜浸潤診断能の検証,
第55回日本肺癌学会学術集会, 2014年11月. 滝沢宏光, 坪井光弘, 武知浩和, 中川靖士, 丹黒章 :
甲状腺未分化癌に対するSorafenibによる治療経験,
第47回日本甲状腺外科学会学術集会, 2014年10月. 坪井光弘, 坂本晋一, 住友弘幸, 中川美砂子, 中川靖士, 滝沢宏光, 丹黒章 :
経口フッ化ピリミジン系抗がん剤による維持療法にて5年の長期生存が得られた甲状腺未分化癌の1例,
第47回日本甲状腺外科学会学術集会, 2014年10月. 中川靖士, 坪井光弘, 滝沢宏光, 丹黒章 :
甲状腺悪性リンパ腫と鑑別を要したIgG4甲状腺炎の1例,
第47回日本甲状腺外科学会学術集会, 2014年10月. 古北由仁, 丹黒章, 住友弘幸, 吉田卓弘 :
食道良性疾患に対するda Vinci手術の経験,
第27回日本内視鏡外科学会総会, 2014年10月. 住友弘幸, 古北由仁, 坂本晋一, 西野豪志, 武知浩和, 清家純一, 吉田卓弘, 丹黒章 :
胸腔鏡下核出術を施行した巨大食道平滑筋種の1例,
第27回日本内視鏡外科学会総会, 2014年10月. 西野豪志, 吉田卓弘, 住友弘幸, 坂本晋一, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
ハイリスク食道癌に対する縦隔鏡下食道切除術,
第67回日本胸部外科学会定期学術集会, 2014年9月. 川上行奎, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
病理病期1期，非小細胞肺癌術後再発例の検討,
第67回日本胸部外科学会定期学術集会, 2014年9月. 古北由仁, 丹黒章, 住友弘幸, 坂本晋一, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
《口演》当科におけるDFP療法を主軸とした切除不能食道癌に対する治療戦略,
第67回日本胸部外科学会定期学術集会, 2014年9月. 吉田卓弘, 古北由仁, 西野豪志, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
《口演》開胸食道切除術後の心血管イベント発症防止に対する塩酸ランジオロールの周術期投与の有用性に関する検討,
第67回日本胸部外科学会定期学術集会, 2014年9月. 先山正二, 鳥羽博明, 吉田光輝, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》胎生期肺組織移植におけるglucocorticoid投与は移植肺組織においてelastinの発現を促進する,
第67回日本胸部外科学会定期学術集会, 2014年9月. 一宮由貴, 鈴木察子, 木田菊恵, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
看護師の補足説明によるがん患者・家族の意思決定支援∼当院の役割拡大実践能力育成プログラムに参加して∼,
第11回日本乳癌学会中国四国地方会, 2014年9月. 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 丹黒章 :
当院における浸潤性小葉癌の臨床病理学的検討,
第11回日本乳癌学会中国四国地方会, 2014年9月. 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
当科で経験した男性乳癌8例の検討,
第11回日本乳癌学会中国四国地方会, 2014年9月. 古北由仁, 丹黒章, 住友弘幸, 坂本晋一, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 滝沢宏光 :
食道良性疾患に対するda Vinci手術の経験,
第89回中国四国外科学会総会・第19回中国四国内視鏡外科研究会, 2014年9月. 住友弘幸, 古北由仁, 坂本晋一, 西野豪志, 武知浩和, 清家純一, 吉田卓弘, 丹黒章 :
胸腔鏡下核出術を施行した巨大食道平滑筋種の1例,
第89回中国四国外科学会総会・第19回中国四国内視鏡外科研究会, 2014年9月. 坂本晋一, 吉田卓弘, 古北由仁, 西野豪志, 住友弘幸, 武知浩和, 丹黒章 :
インドシアニングリーン蛍光法による血流評価が困難であった有茎空腸再建の1例,
第89回中国四国外科学会総会・第19回中国四国内視鏡外科研究会, 2014年9月. 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 丹黒章 :
浸潤性小葉癌腹膜播種の2例,
第52回日本癌治療学会学術集会, 2014年8月. 武知浩和, 森本雅美, 西野豪志, 中川美砂子, 古北由仁, 吉田卓弘, 田所由紀子, 丹黒章 :
化学療法が著効し手術を施行した転移性乳癌の1例,
第52回日本癌治療学会学術集会, 2014年8月. 西野豪志, 吉田卓弘, 森本雅美, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
高齢者食道癌(75歳以上)に対する術前化学療法における問題点,
第52回日本癌治療学会学術集会, 2014年8月. 森本雅美, 武知浩和, 中川美砂子, 田所由紀子, 丹黒章 :
化学療法奏功後Fulvestrant投与にて病勢維持に成功した再発乳癌の1例,
第52回日本癌治療学会学術集会, 2014年8月. 坂本晋一, 古北由仁, 住友弘幸, 森下敦司, 森本雅美, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
DFP化学療法(weekly DOC+low dose FP)が奏効した食道内分泌細胞癌の3例,
第52回日本癌治療学会学術集会, 2014年8月. 住友弘幸, 古北由仁, 坂本晋一, 森下敦司, 森本雅美, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
DFP療法で病理学的完全奏効が得られたcT4食道扁平上皮癌の3例,
第52回日本癌治療学会学術集会, 2014年8月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
食道癌治療における血清p53抗体価測定の意義,
第52回日本癌治療学会学術集会, 2014年8月. 吉田卓弘, 古北由仁, 西野豪志, 森下敦司, 武知浩和, 丹黒章 :
進行食道癌に対する食道ステント治療と食道バイパス手術の検証,
第69回日本消化器外科学会総会, 2014年7月. 西野豪志, 吉田卓弘, 古北由仁, 山本洋太, 武知浩和, 丹黒章 :
食道癌周術期における大建中湯の有用性についての検討,
第69回日本消化器外科学会総会, 2014年7月. 丹黒章, 宮田裕章, 古北由仁, 吉田卓弘, 今野弘之, 友滝愛, 後藤満一, 若林剛, 森正樹 :
《パネルディスカッション》[データベース報告]NCDデータに基づいた結腸右半切除術のリスク評価,
第69回日本消化器外科学会総会, 2014年7月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 梶浦耕一郎, 武知浩和, 吉田卓弘, 清家純一 :
《パネルディスカッション》食道切除・再建術におけるE-PASSスコアの有用性と術後合併症の軽減を目指した試み,
第69回日本消化器外科学会総会, 2014年7月. 武知浩和, 中川美砂子, 森本雅美, 田所由紀子, 丹黒章 :
化学療法先行後に残存肺転移を摘出し長期生存中の転移性乳癌の1例,
第22回日本乳癌学会学術総会, 2014年7月. 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
画像による術前化学療法効果判定の精度,
第22回日本乳癌学会学術総会, 2014年7月. 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
CT lymphography(CTLG)によるリンパ節転移診断の評価,
第22回日本乳癌学会学術総会, 2014年7月. 中川美砂子, 森本雅美, 武知浩和, 田所由紀子, 丹黒章 :
当院における家族性乳癌の傾向-「遺伝相談室」の役割拡充に向けて-,
第22回日本乳癌学会学術総会, 2014年7月. 三木仁司, 日野直樹, 古味勝美, 小田芳栄, 辻優子, 豊崎纒, 丹黒章 :
乳がん検診無料クーポン券の効果と課題,
第22回日本乳癌学会学術総会, 2014年7月. 一宮由貴, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
《ポスターディスカッション》当院の役割拡大実践能力育成プログラムにおける患者・家族の意思決定支援,
第22回日本乳癌学会学術総会, 2014年7月. 西野豪志, 吉田卓弘, 山本洋太, 古北由仁, 武知浩和, 丹黒章 :
食道癌周術期における大建中湯投与の有用性についての検討,
第68回日本食道学会学術集会, 2014年7月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
当科における切除不能食道癌に対する治療戦略,
第68回日本食道学会学術集会, 2014年7月. 石川久子, 永井浩美, 吉岡昌美, 伊賀弘起, 東雅之, 松尾敬志, 丹黒章 :
外来化学療法患者の口腔健康管理に対する意識調査,
第11回日本口腔ケア学会・旭川, 2014年6月. 西野豪志, 吉田卓弘, 山本洋太, 古北由仁, 武知浩和, 丹黒章 :
食道癌周術期管理における大建中湯の有用性についての検討,
第57回関西胸部外科学会学術集会, 2014年6月. 吉田卓弘, 古北由仁, 西野豪志, 森下敦司, 武知浩和, 清家純一, 丹黒章 :
T4食道癌に対する食道ステント治療と食道バイパス手術の検討,
第57回関西胸部外科学会学術集会, 2014年6月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
当科における切除不能食道癌に対する治療戦略,
第57回関西胸部外科学会学術集会, 2014年6月. 坪井光弘, 森下敦司, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
《要望ビデオセッション:手術手技》呼吸器外科手術におけるPowered ECHELON FLEXTMの使用経験,
第57回関西胸部外科学会学術集会, 2014年6月. 古北由仁, 吉田卓弘, 西野豪志, 森下敦司, 森本雅美, 坪井光弘, 武知浩和, 清家純一, 丹黒章, 中山泰介, 木下肇, 藤本鋭貴 :
《Case Presentation Awards》食道癌放射線治療後の食道大動脈瘻に対する大動脈ステント内挿術で難渋した1例,
第57回関西胸部外科学会学術集会, 2014年6月. 坂本晋一, 梶浦耕一郎, 武知浩和, 森下敦司, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
診断困難であったgefitinib投与中に発生した肺癌術後脳転移の1例,
第31回日本呼吸器外科学会総会, 2014年5月. 先山正二, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章, 浜口伸正, 吉澤潔, 木村秀, 住友正幸, 三好孝典, 日野弘之 :
呼吸器外科専門医の育成と維持-地域の現状と今後-,
第31回日本呼吸器外科学会総会, 2014年5月. 住友弘幸, 滝沢宏光, 先山正二, 吉田光輝, 坂本晋一, 森下敦司, 西野豪志, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 丹黒章, 近藤和也 :
肺原発滑膜肉腫の1切除例,
第31回日本呼吸器外科学会総会, 2014年5月. 川上行奎, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
発症から数ヵ月を経て診断された後，異なる治療経過をたどった肺切除後，気管支断端瘻の2例,
第31回日本呼吸器外科学会総会, 2014年5月. 森下敦司, 滝沢宏光, 近藤和也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 丹黒章, 河北直也, 広瀬敏幸, 住友正幸 :
胸膜浸潤の術中評価はどの程度正確か,
第31回日本呼吸器外科学会総会, 2014年5月. 梶浦耕一郎, 先山正二, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般ビデオ》ジェット換気を用いた気管腺様嚢胞癌に対する気管環状切除の1例,
第31回日本呼吸器外科学会総会, 2014年5月. 坪井光弘, 滝沢宏光, 森下敦司, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《一般口演》肺癌手術症例における胸膜浸潤とリンパ節転移に関する検討,
第31回日本呼吸器外科学会総会, 2014年5月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 森下敦司, 西野豪志, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
《要望ビデオ》胸膜の自家蛍光を用いた胸膜浸潤の術中診断,
第31回日本呼吸器外科学会総会, 2014年5月. 西野豪志, 先山正二, 森下敦司, 坪井光弘, 梶浦耕一郎, 滝沢宏光, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《要望演題》難治性気胸に対する治療戦略∼当科における胸腔内フィブリン糊注入療法の成績と工夫∼,
第31回日本呼吸器外科学会総会, 2014年5月. 長瀬紗季, 梶浦耕一郎, 滝沢宏光, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
慢性有ろう性膿胸に対する人工呼吸管理下のEWSによる気管支充填術が有効であった1例,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 先山正二, 鳥羽博明, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植における気道系の分化とbranchingに関する検討,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 先山正二, 森下敦司, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡関連医療事故の分析とその対応を考える,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 坪井光弘, 森下敦司, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
自家蛍光観察による胸膜浸潤の術中診断精度向上にむけた取り組み,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 西野豪志, 吉田卓弘, 森下敦司, 古北由仁, 山本洋太, 武知浩和, 丹黒章 :
女性の食道癌は男性よりも予後良好である∼食道癌切除症例の臨床病理学的特徴と予後におよぼす姓差∼,
第114回日本外科学会定期学術集会, 2014年4月. 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 森下敦司, 山本洋太, 清家純一, 丹黒章 :
頸部食道癌に対する手術のタイミング,
第114回日本外科学会定期学術集会, 2014年4月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 梶浦耕一郎, 山本洋太, 武知浩和, 吉田卓弘, 清家純一 :
食道癌化学療法におけるエイコサペンタエン酸強化栄養剤の導入効果,
第114回日本外科学会定期学術集会, 2014年4月. 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
CTリンパ管造影を用いたリンパ節転移の評価による術前化学療法後のセンチネルリンパ節生検についての検討,
第114回日本外科学会定期学術集会, 2014年4月. 先山正二, 滝沢宏光, 梶浦耕一郎, 坪井光弘, 中川靖士, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《ビデオシンポジウム》肺癌に対するロボット補助下肺葉切除術-とくに触覚の決如に関して-,
第114回日本外科学会定期学術集会, 2014年4月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
《シンポジウム》肺癌区域切除におけるリンパ節転移と胸膜浸潤の術中診断精度向上に向けた取り組み,
第114回日本外科学会定期学術集会, 2014年4月. 田所由紀子, 中川美砂子, 森本雅美, 武知浩和, 丹黒章 :
《ワークショップ》CT lymphography(CTLG)によるリンパ節転移診断の評価,
第23回日本乳癌画像研究会, 2014年3月. 梶浦耕一郎, 先山正二, 坪井光弘, 吉田光輝, 森下敦司, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
術前気道確保に気管支鏡下高周波スネア切除術が有効であった気管腺様嚢胞癌の1例,
第22回日本呼吸器内視鏡学会中国四国支部会, 2014年2月. 劉環, 近藤和也, 板東孝枝, 梶浦耕一郎, 今井芳枝, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 先山正二, 丹黒章 :
手術療法施行した肺がん患者におけるpatient reported quality of life(PRQOL)の評価,
第54回日本肺癌学会総会, 2013年11月. 滝沢宏光, 近藤和也, 大谷環樹, 大塚秀樹, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
PET/CTによるヒト肺癌細胞株肺移植モデルマウスの腫瘍評価,
第54回日本肺癌学会総会, 2013年11月. 中川靖士, 近藤和也, 先山正二, 川上行奎, 滝沢宏光, 吉田光輝, 梶浦耕一郎, 坪井光弘, 丹黒章 :
胸腺上皮性腫瘍83例の検討,
第54回日本肺癌学会総会, 2013年11月. 川上行奎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
当科における異時性多発肺癌手術例の検討,
第54回日本肺癌学会総会, 2013年11月. 新井悠太, 古北由仁, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道癌化学放射線療法中に中心静脈カテーテル感染より発生した化膿性脊椎炎の1例,
第75回日本臨床外科学会総会, 2013年11月. 梶浦耕一郎, 先山正二, 森下敦司, 西野豪志, 坪井光弘, 古北由仁, 武知浩和, 吉田卓弘, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
褐色細胞腫肺転移の1切除例,
第75回日本臨床外科学会総会, 2013年11月. 武知浩和, 滝沢宏光, 山本洋太, 西野豪志, 古川尊子, 梶浦耕一郎, 森本雅美, 中川美砂子, 田所由紀子, 先山正二, 丹黒章 :
癌性胸膜炎加療数日後に癌性心膜炎から心タンポナーデを発症しOncological emergencyに陥った再発乳癌の1例,
第75回日本臨床外科学会総会, 2013年11月. 乾友浩, 武知浩和, 滝沢宏光, 中川靖士, 坪井光弘, 新井悠太, 森下敦司, 西野豪志, 梶浦耕一郎, 古北由仁, 吉田卓弘, 丹黒章 :
縦隔内甲状腺腫の2切除例,
第75回日本臨床外科学会総会, 2013年11月. 森下敦司, 古北由仁, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
放射線治療が再発巣コントロールに有効であった食道原発悪性黒色腫の一例,
第75回日本臨床外科学会総会, 2013年11月. 古北由仁, 丹黒章, 荒井悠太, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
食道癌術後合併症の軽減を目指した術前リスク評価と術式選択,
第75回日本臨床外科学会総会, 2013年11月. 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
当院における検診精密検査結果の検討,
第23回日本乳癌検診学会学術総会, 2013年11月. 森本雅美, 田所由紀子, 中川美砂子, 武知浩和, 丹黒章 :
2年前の検診マンモグラフィで陰性であった進行乳癌の1例,
第23回日本乳癌検診学会学術総会, 2013年11月. 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
当科での妊娠関連乳癌症例の検討,
第51回日本癌治療学会学術集会, 2013年10月. Mohammed Mokhtar, 田所由紀子, 中川美砂子, 森本雅美, 武知浩和, 近藤和也, 丹黒章 :
当院における乳癌センチネルリンパ節生検(CTリンパ管造影，色素法，蛍光法，OSNA法),
第51回日本癌治療学会学術集会, 2013年10月. 西野豪志, 吉田卓弘, 山本洋太, 古北由仁, 武知浩和, 丹黒章 :
食道扁平上皮癌切除症例の臨床病理学的特徴と予後における性差,
第51回日本癌治療学会学術集会, 2013年10月. 梶浦耕一郎, 近藤和也, 滝沢宏光, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 古北由仁, 西野豪志, 吉田卓弘, 先山正二, 丹黒章 :
胸腺腫術後再発治療の検討,
第66回日本胸部外科学会定期学術集会, 2013年10月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
当科における食道癌術後合併症の軽減を目指した試み,
第66回日本胸部外科学会定期学術集会, 2013年10月. 吉田光輝, 先山正二, 日野弘之, 高嶋美佳, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章 :
解剖学的破格を伴う胸部手術症例,
第66回日本胸部外科学会定期学術集会, 2013年10月. 先山正二, 吉田光輝, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植におけるGlucocorticoid投与は移植肺の分化を促進する,
第66回日本胸部外科学会定期学術集会, 2013年10月. 梶浦耕一郎, 井本逸勢, 増田清士, 田嶋敦, 近藤和也, 丹黒章 :
ゲノムワイドな異常DNAメチル化探索によるにおける新規メチル化標的喫煙関連肺腺癌抑制遺伝子の同定,
第72回日本癌学会学術総会, 2013年10月. 中川靖士, 滝沢宏光, 坪井光弘, 丹黒章 :
反回神経麻痺をきたした腺腫様甲状腺腫の1例,
第46回日本甲状腺外科学会学術集会, 2013年9月. 坪井光弘, 滝沢宏光, 中川靖士, 武知浩和, 西野豪志, 森本雅美, 森下敦司, 丹黒章 :
長期生存を得ている甲状腺髄様癌術後肝転移の1例,
第46回日本甲状腺外科学会学術集会, 2013年9月. 高橋知也, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子 :
ロックインアンプを用いた多電極生体インピーダンス測定装置の検討,
平成25年度電気関係学会四国支部連合大会講演論文集, 239, 2013年9月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合には，測定信号のSNRが小さいことが多く，測定が困難である．そこで耐雑音性に優れるロックインアンプを製作し，測定の安定化を図った．

岩見誠治, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子, 高橋知也 :
生体組織インピーダンスのばらつきを考慮したインピーダンス測定装置の電極配置について,
平成25年度電気関係学会四国支部連合大会講演論文集, 238, 2013年9月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合，電流が拡散するため局所的な腫瘍組織のインピーダンスを測定することが困難である．そこで複数の電極対を切り替えることにより標的とする領域のインピーダンスを測定することを試みている．

森本雅美, 田所由紀子, 森下敦司, 中川美砂子, 武知浩和, 丹黒章 :
術前診断に難渋した乳腺腺様嚢胞癌の1例,
第10回日本乳癌学会中国四国地方会, 2013年9月. 森下敦司, 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
急速に増大した葉状腫瘍の2例,
第10回日本乳癌学会中国四国地方会, 2013年9月. 武知浩和, 滝沢宏光, 山本洋太, 古川尊子, 西野豪志, 梶浦耕一郎, 森本雅美, 中川美砂子, 田所由紀子, 先山正二, 丹黒章 :
癌性胸膜炎加療数日後に癌性心膜炎から心タンポナーデを発症しOncological emergencyに陥った再発乳癌の1例,
第10回日本乳癌学会中国四国地方会, 2013年9月. 中川美砂子, 森下敦司, 森本雅美, 武知浩和, 田所由紀子, 丹黒章 :
S-1+Docetaxel併用術前化学療法臨床試験(N-1 trial)中間報告 —ER陽性乳癌の効果の検討-,
第10回日本乳癌学会中国四国地方会, 2013年9月. 新井悠太, 古北由仁, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道癌化学放射線療法中に中心静脈カテーテル感染より発生した化膿性脊椎炎の1例,
第88回中国四国外科学会総会, 2013年9月. 森下敦司, 古北由仁, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
放射線治療が再発巣コントロールに有効であった食道原発悪性黒色腫の一例,
第88回中国四国外科学会総会, 2013年9月. 吉田卓弘, 古北由仁, 西野豪志, 武知浩和, 森下敦司, 池田真由美, 森本雅美, 湊拓也, 後藤正和, 山本洋太, 三好孝典, 丹黒章 :
胸部食道癌に対する集学的治療として食道バイパス術を行った3例,
第88回中国四国外科学会総会, 2013年9月. 中林えみ, 武知浩和, 滝沢宏光, 山本洋太, 古川尊子, 西野豪志, 梶浦耕一郎, 森本雅美, 森下敦司, 坪井光弘, 中川美砂子, 古北由仁, 吉田卓弘, 田所由紀子, 先山正二, 丹黒章 :
癌性胸膜炎加療数日後に癌性心膜炎から心タンポナーデを発症しOncological emergencyに陥った再発乳癌の1例,
第88回中国四国外科学会総会, 2013年9月. 中川美砂子, 森下敦司, 森本雅美, 西野豪志, 坪井光弘, 梶浦耕一郎, 古北由仁, 武知浩和, 吉田卓弘, 中川靖士, 川上行奎, 滝沢宏光, 吉田光輝, 田所由紀子, 先山正二, 丹黒章 :
データベースによる乳がん登録の問題点と当科における乳癌患者の傾向,
第88回中国四国外科学会総会, 2013年9月. 乾友浩, 武知浩和, 滝沢宏光, 中川靖士, 坪井光弘, 新井悠太, 森本雅美, 西野豪志, 中川美砂子, 古北由仁, 吉田卓弘, 田所由紀子, 丹黒章 :
呼吸困難を呈した超高齢者発症縦隔内甲状腺腫瘤の1切除例,
第88回中国四国外科学会総会, 2013年9月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
《シンポジウム》食道癌術後合併症の軽減を目指した術前リスク評価と術式選択,
第88回中国四国外科学会総会, 2013年9月. 吉田光輝, 先山正二, 森下敦司, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科領域におけるQuantiFERON-TB検査の医療安全面からの有用性,
第49回日本呼吸器学会中国四国地方会・第52回日本肺癌学会中国四国支部会, 2013年7月. 森下敦司, 滝沢宏光, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
甲状腺癌多発肺転移に原発性肺癌を合併した1例,
第49回日本呼吸器学会中国四国地方会・第52回日本肺癌学会中国四国支部会, 2013年7月. 後藤正和, 丹黒章, 池田真由美, 古川尊子, 西野豪志, 梶浦耕一郎, 古北由仁, 山本洋太, 武知浩和, 清家純一 :
当科における食道癌術後吻合部狭窄症例の検討,
第68回日本消化器外科学会総会, 2013年7月. 古北由仁, 湊拓也, 丹黒章, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
食道癌術後合併症の軽減を目指した術前リスク評価と術式選択,
第68回日本消化器外科学会総会, 2013年7月. 西野豪志, 丹黒章, 池田真由美, 古川尊子, 後藤正和, 山本洋太, 古北由仁, 梶浦耕一郎, 武知浩和, 清家純一 :
食道扁平上皮癌に対する術前DFP療法(weekly DOC+low-dose FP)の有効性,
第68回日本消化器外科学会総会, 2013年7月. 山本洋太, 池田真由美, 古川尊子, 西野豪志, 後藤正和, 古北由仁, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
食道癌周術期における大建中湯投与の有用性の検討,
第68回日本消化器外科学会総会, 2013年7月. 池田真由美, 田所由紀子, 古川尊子, 森本雅美, 中川美砂子, 武知浩和, 中川靖士, 丹黒章 :
乳腺matrix-producing carcinomaの2例,
第21回日本乳癌学会学術総会, 2013年6月. 古川尊子, 中川美砂子, 田所由紀子, 池田真由美, 森本雅美, 武知浩和, 中川靖士, 丹黒章 :
サブタイプ別再発形式から考えた乳癌術後フォローアップの検討,
第21回日本乳癌学会学術総会, 2013年6月. 武知浩和, 森本雅美, 古川尊子, 中川美砂子, 田所由紀子, 丹黒章 :
再発乳癌加療中に発症した悪性リンパ腫によりOncological emergencyをきたした1例,
第21回日本乳癌学会学術総会, 2013年6月. 田所由紀子, 中川美砂子, 池田真由美, 古川尊子, 森本雅美, 武知浩和, 中川靖士, 丹黒章 :
CTリンパ管造影(CTLG)のリンパルートの解析によるセンチネルリンパ節転移陽性例の郭清の省略についての検討,
第21回日本乳癌学会学術総会, 2013年6月. 中川美砂子, 坂東良美, 笹三徳, 森谷卓也, 丹黒章, 高井チカコ, 田所由紀子, 武知浩和, 森本雅美, 古川尊子, 池田真由美 :
Triple Negative乳癌におけるTS，DPD発現の検討,
第21回日本乳癌学会学術総会, 2013年6月. 森本雅美, 中川美砂子, 坂東良美, 本田純子, 吉田卓弘, 須見高尚, 高橋雅子, 田所由紀子, 笹三徳, 丹黒章, 池田真由美, 古川尊子, 武知浩和 :
乳癌組織の細胞診検体での免疫染色が組織診検体の免疫染色に代替可能であるか否かの検討,
第21回日本乳癌学会学術総会, 2013年6月. 池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科治療抵抗性の乳児気管支肉芽に対してHo : YAGレーザー焼灼術を施行した1例,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 滝沢宏光, 梶浦耕一郎, 池田真由美, 古川尊子, 西野豪志, 森本雅美, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《シンポジウム》術前経気管支水溶性造影剤注入CTリンパ管造影法による肺癌センチネルリンパ節同定,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 吉田光輝, 先山正二, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》QuantiFERON-TB検査の呼吸器外科領域における医療安全面からの有用性,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 梶浦耕一郎, 先山正二, 滝沢宏光, 池田真由美, 古川尊子, 森本雅美, 中川靖士, 川上行奎, 吉田光輝, 近藤和也, 豊田優子, 手塚敏史, 木下勝弘, 青野純典, 西岡安彦, 丹黒章 :
《ワークショップ》気管支鏡破損症例の検討,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 池田真由美, 西野豪志, 先山正二, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫術後に両側横隔神経麻痺による呼吸不全をきたした1例,
第56回関西胸部外科学会学術集会, 2013年6月. 西野豪志, 山本洋太, 後藤正和, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
《シンポジウム》食道扁平上皮癌に対する術前DFP療法(weekly DOC+low-dose FP)の有効性,
第56回関西胸部外科学会学術集会, 2013年6月. 古北由仁, 湊拓也, 丹黒章, 坂本晋一, 宮本佳美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
《シンポジウム》食道癌術後合併症の軽減を目指した術前リスク評価と術式選択,
第56回関西胸部外科学会学術集会, 2013年6月. 古北由仁, 丹黒章, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
食道癌化学療法におけるEPA強化栄養剤(プロシュア®)導入効果,
第67回日本食道学会学術集会, 2013年6月. 山本洋太, 西野豪志, 後藤正和, 古北由仁, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道亜全摘術後の長期的体重変化の検討,
第67回日本食道学会学術集会, 2013年6月. 後藤正和, 西野豪志, 湊拓也, 古北由仁, 山本洋太, 湯浅康弘, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道切除・胃管再建術後の吻合部狭窄症例の検討,
2013年6月. 河北直也, 古北由仁, 丹黒章, 池田真由美, 古川尊子, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
Niti-STM食道ステントロングカバータイプが有用であった下部食道癌の1例,
第67回日本食道学会学術集会, 2013年6月. 西野豪志, 山本洋太, 後藤正和, 古北由仁, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道扁平上皮癌に対する術前DFP療法(weekly DOC+low-dose FP)の有効性,
第67回日本食道学会学術集会, 2013年6月. 山本洋太, 坂本晋一, 西野豪志, 後藤正和, 古北由仁, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道癌治療におけるHER-family蛋白発現と治療効果・予後との関連の検討,
第38回日本外科系連合学会学術集会, 2013年6月. 古北由仁, 丹黒章, 坂本晋一, 宮本佳美, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 梶浦耕一郎, 武知浩和, 清家純一 :
食道癌化学療法におけるEPA強化栄養剤(プロシュア®)導入効果の検討,
第38回日本外科系連合学会学術集会, 2013年6月. 田所由紀子, 中川美砂子, 森本雅美, 武知浩和, 丹黒章 :
乳房温存療法の現状と成績,
第38回日本外科系連合学会学術集会, 2013年6月. 川上行奎, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
胸腺上皮性腫瘍におけるFDG PET-CTの有用性‐組織型，正岡分類との関連性につき-,
第30回日本呼吸器外科学会総会, 2013年5月. 池田真由美, 吉田光輝, 先山正二, 古川尊子, 梶浦耕一郎, 武知浩和, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
サルコイドーシス合併肺腺癌術後にSIADHを合併した1例,
第30回日本呼吸器外科学会総会, 2013年5月. 梶浦耕一郎, 滝沢宏光, 先山正二, 古川尊子, 西野豪志, 森本雅美, 吉田光輝, 川上行奎, 中川靖士, 近藤和也, 丹黒章 :
塩酸ランジオロールの肺葉切除後上室性不整脈予防効果の検討,
第30回日本呼吸器外科学会総会, 2013年5月. 古川尊子, 吉田光輝, 先山正二, 池田真由美, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
非連続性多発性腫瘤を呈した悪性胸膜中皮腫の1手術例,
第30回日本呼吸器外科学会総会, 2013年5月. 吉田光輝, 先山正二, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章 :
侵襲型肺アスペルギルス症に対する右肺全摘術の経験,
第30回日本呼吸器外科学会総会, 2013年5月. 先山正二, 滝沢宏光, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
縦隔型舌区動脈を有する肺癌症例に対するロボット補助下左上葉切除術,
第30回日本呼吸器外科学会総会, 2013年5月. 吉田光輝, 近藤和也, 中川靖士, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
重症筋無力症患者の術前3D画像解析が拡大胸腺摘出術後の予後予測に及ぼす可能性,
第113回日本外科学会定期学術集会, 2013年4月. 古北由仁, 丹黒章, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 梶浦耕一郎, 武知浩和, 清家純一 :
好中球リンパ球比は食道癌の予後・効果予測因子となりうる,
第113回日本外科学会定期学術集会, 2013年4月. 梶浦耕一郎, 川上行奎, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 中川靖士, 吉田光輝, 滝沢宏光, 田所由紀子, 先山正二, 近藤和也, 丹黒章 :
YAGレーザー使用時の気管支鏡破損の1例,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 古川尊子, 吉田光輝, 梶浦耕一郎, 先山正二, 滝沢宏光, 森本雅美, 武知浩和, 池田真由美, 西野豪志, 中川靖士, 川上行奎, 近藤和也, 丹黒章 :
当科における気管支鏡検査へのLung pointの経験,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 後藤正和, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科的治療抵抗性の乳児気管支肉芽に対してHo:YAGレーザー焼灼術を施行した1例,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 高井ちか子, 中川靖士, 大岩由香里, 藤田結衣, 滝沢宏光, 吉田光輝, 川上行奎, 梶浦耕一郎, 先山正二, 丹黒章, 高浜洋介, 近藤和也 :
ヒト胸腺・胸腺腫における皮質・髄質 component の distribution,
第32回日本胸腺研究会, 2013年2月. 古北由仁, 丹黒章, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
腹腔鏡下核手術を施行した食道平滑筋腫の1例,
第25回日本内視鏡外科学会総会, 2012年12月. 坂本晋一, 古北由仁, 丹黒章, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
食道内分泌細胞癌の2例,
第74回日本臨床外科学会総会, 2012年11月. 梶浦耕一郎, 滝沢宏光, 近藤和也, 池田真由美, 古川尊子, 西野豪志, 後藤正和, 山本洋太, 古北由仁, 森本雅美, 吉田光輝, 中川靖士, 川上行奎, 先山正二, 丹黒章 :
周術期に骨髄異形成症候群を発症した肺小細胞癌の1例,
第74回日本臨床外科学会総会, 2012年11月. 古北由仁, 丹黒章, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
食道癌根治手術後の再発症例に対する検討,
第74回日本臨床外科学会総会, 2012年11月. 山本洋太, 池田真由美, 古川尊子, 西野豪志, 後藤正和, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
食道胃管吻合部の再建術後に生じた難治性消化管皮膚瘻に対し，腸脛靱帯筋膜パッチ，有茎大胸筋皮弁充填術で治癒せしめた一例,
第74回日本臨床外科学会総会, 2012年11月. 後藤正和, 丹黒章, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 梶浦耕一郎, 古北由仁, 山本洋太, 武知浩和, 清家純一 :
食道癌術後早期の血清C-Reactive Protein値は術後縫合不全の予測因子となる,
第74回日本臨床外科学会総会, 2012年11月. 西野豪志, 滝沢宏光, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
進行肺癌に合併した難治性続発性気胸に対する胸腔内フィブリン糊注入療法の有用性,
第74回日本臨床外科学会総会, 2012年11月. 古北由仁, 丹黒章, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
食道癌手術のリスク評価におけるE-PASSの有用性,
第25回日本外科感染症学会総会学術集会, 2012年11月. 吉田光輝, 先山正二, 森本雅美, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
非連続性多発性腫瘤を呈した悪性胸膜中皮腫の1手術例,
第53回日本肺癌学会総会, 2012年11月. 田岡真理子, 広瀬敏幸, 住友正幸, 松岡永, 葉久貴司, 米田和夫, 稲山真美, 川上行奎, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
肺硬化性血管腫の4例,
第53回日本肺癌学会総会, 2012年11月. 川上行奎, 先山正二, 滝沢宏光, 近藤和也, 丹黒章, 広瀬敏幸, 住友正幸, 三好孝典, 石倉久嗣, 木村秀, 監﨑孝一郎, 吉澤潔, 谷田信行, 浜口伸正, 日野弘之, 福本泰三 :
当院および関連7施設から集計した肺多形癌手術例の臨床的検討,
第53回日本肺癌学会総会, 2012年11月. 滝沢宏光, 近藤和也, 石倉久嗣, 木村秀, 坂本晋一, 宮本佳美, 森本雅美, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
非小細胞肺癌完全切除例に対するS-1術後補助化学療法の遺伝子発現解析による効果・予後予測因子の検討,
第53回日本肺癌学会総会, 2012年11月. 宮本佳美, 滝沢宏光, 近藤和也, 石倉久嗣, 木村秀, 坂本晋一, 森本雅美, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
非小細胞肺癌完全切除例に対するS-1術後補助化学療法の投与完遂性に関する検討,
第53回日本肺癌学会総会, 2012年11月. 猪子拓人, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子, 高橋知也, 岩見誠治 :
生体インピーダンスを用いた腫瘍の質的診断のための電極配置の検討,
第35回日本生体医工学会中国四国支部大会講演抄録, 17, 2012年10月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合，電流が拡散するため局所的な腫瘍組織のインピーダンスを測定することが困難である．そこで複数の電極対を切り替えることにより標的とする領域のインピーダンスを測定することを試み，計算機シミュレーションにより電極の切り替え法について検討した．

森本雅美, 池田真由美, 古川尊子, 中川美砂子, 武知浩和, 滝沢宏光, 吉田光輝, 田所由紀子, 丹黒章 :
第50回日本癌治療学会学術集会,
乳癌胸髄転移に対して緊急放射線照射を行い自宅療養可能となった一例, 2012年10月. 山本洋太, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
第50回日本癌治療学会学術集会,
食道癌周術期における大建中湯投与の有用性の検討, 2012年10月. 武知浩和, 池田真由美, 古川尊子, 森本雅美, 中川美砂子, 中川靖士, 吉田光輝, 田所由紀子, 丹黒章 :
第50回日本癌治療学会学術集会,
再発乳癌加療中に発症した悪性リンパ腫によりoncological emergencyをきたした1例, 2012年10月. 滝沢宏光, 近藤和也, 西野豪志, 森本雅美, 梶浦耕一郎, 武知浩和, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
肺腺癌術後再発症例に対するEGFR-TKI投与の位置づけに関する検討,
第65回日本胸部外科学会定期学術集会, 2012年10月. 梶浦耕一郎, 滝沢宏光, 森本雅美, 西野豪志, 古北由仁, 山本洋太, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
自家蛍光による肺癌胸膜浸潤評価の可能性,
第65回日本胸部外科学会定期学術集会, 2012年10月. 梶浦耕一郎, 滝沢宏光, 鳥羽博明, 森本雅美, 西野豪志, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
触知不能肺腫瘍に対する術前細径気管支鏡下コイルマーキングの有用性と安全性,
第65回日本胸部外科学会定期学術集会, 2012年10月. 猪子拓人, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子, 高橋知也, 岩見誠治 :
生体インピーダンス測定による腫瘍の質的診断の検討,
電気関係学会四国支部連合大会講演論文集, 261, 2012年9月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．皮膚表面の電極ついに一定電圧を印加し，腫瘍部分のインピーダンスの推定が可能かについて有限要素法により検討した．その結果，皮膚表面に現れる電圧分布の差異は非常に小さく，インピーダンス推定が非常に困難であることが示された．

高橋知也, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子 :
多電極生体インピーダンス測定装置の試作,
電気関係学会四国支部連合大会講演論文集, 260, 2012年9月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．多電極の生体インピーダンス測定装置を試作し，大腿部のインピーダンスの測定を行い，有用性を検証した．

岩見誠治, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子, 猪子拓人, 高橋知也 :
生体等価回路シミュレーションを用いた多電極インピーダンス測定装置の検討,
電気関係学会四国支部連合大会講演論文集, 259, 2012年9月.

(要約): 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．3パラメータの2次元生体組織回路網モデルを構築し，組織内の電流分布を解析した．電流電極を切り替える事で，電流の流れる層が変化する事や，電圧変化があることを示した．

武知浩和, 森本雅美, 西野豪志, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
診断に難渋したゲフィチニブ投与中に発生した肺癌術後脳転移の1症例,
第47回日本呼吸器学会中国・四国地方会/第51回日本肺癌学会中国・四国支部会, 2012年7月. 後藤正和, 丹黒章, 森本雅美, 梶浦耕一郎, 古北由仁, 山本洋太, 武知浩和, 清家純一 :
食道類基底細胞癌の3切除例,
第67回日本消化器外科学会総会, 2012年7月. 湊拓也, 山本洋太, 森本雅美, 後藤正和, 古北由仁, 武知浩和, 清家純一, 丹黒章, 坂東良美 :
ALDH1と食道扁平上皮癌の予後に関する検討,
第67回日本消化器外科学会総会, 2012年7月. 山本洋太, 森本雅美, 後藤正和, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
食道亜全摘術時に造設した腸瘻刺入部が要因と考えられる術後腸閉塞の検討,
第67回日本消化器外科学会総会, 2012年7月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道癌治療におけるGlasgow prognostic scoreを用いたリスク評価,
第67回日本消化器外科学会総会, 2012年7月. 宮本佳美, 中川美砂子, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
当科における高齢者乳がんの検討,
第20回日本乳癌学会学術総会, 2012年6月. 中川靖士, 中川美砂子, 坂東良美, 長尾妙子, 高井チカ子, 大西隆仁, 本田純子, 森谷卓也, 泉啓介, 高橋雅子, 丹黒章, 笹三徳 :
Triple Negative乳癌(TN乳癌)においてHER2(0)はHER2(1+)に比べてBasal-like傾向が強い,
第20回日本乳癌学会学術総会, 2012年6月. 森本雅美, 中川美砂子, 武知浩和, 川上行奎, 吉田光輝, 滝沢宏光, 監﨑孝一郎, 丹黒章 :
CTリンパ管造影(CTLG)を用いた術前化学療法(PST)前後のセンチネルリンパ節(SLN)とリンパ路の評価,
第20回日本乳癌学会学術総会, 2012年6月. 中川美砂子, 丹黒章 :
《パネルディスカッション》乳腺専門医取得の意義,
第20回日本乳癌学会学術総会, 2012年6月. 古北由仁, 丹黒章, 森本雅美, 後藤正和, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
当科における食道癌脳転移の検討,
第55回関西胸部外科学会学術集会, 2012年6月. 古北由仁, 丹黒章, 森本雅美, 後藤正和, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
食道癌における好中球リンパ球比(neutrophil lymphocyte ratio:NLR)の意義,
第66回日本食道学会学術集会, 2012年6月. 後藤正和, 丹黒章, 山本洋太, 森本雅美, 梶浦耕一郎, 古北由仁, 武知浩和, 清家純一 :
食道癌術後横隔膜ヘルニアの1例,
第66回日本食道学会学術集会, 2012年6月. 山本洋太, 山井礼道, 清家純一, 吉田卓弘, 湯浅康弘, 森本雅美, 後藤正和, 古北由仁, 武知浩和, 丹黒章 :
食道癌治療におけるHER蛋白発現と治療効果・予後との関連の検討,
第66回日本食道学会学術集会, 2012年6月. 西野豪志, 山本洋太, 森本雅美, 湊拓也, 後藤正和, 古北由仁, 湯浅康弘, 武知浩和, 清家純一, 丹黒章 :
集学的治療に喉頭温存手術が可能となった高度進行頚部食道類基底細胞癌の一例,
第66回日本食道学会学術集会, 2012年6月. 梶浦耕一郎, 先山正二, 森本雅美, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
Lung pointとBf-Naviの気管支自動認識能の検討,
第35回日本呼吸器内視鏡学会学術集会, 2012年5月. 先山正二, 川上行奎, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
当科におけるmulti-modality methodによる気管支鏡教育-特に技能評価方法の実際について-,
第35回日本呼吸器内視鏡学会学術集会, 2012年5月. M Nakagawa, S Nishio, 山田博胤, 中川美砂子, 武知浩和, 川上行奎, M Morimoto, 佐田政隆, 丹黒章 :
超音波検査による乳癌術前化学療法の効果予測,
日本超音波医学会第85回学術集会, 2012年5月. 吉田光輝, 近藤和也, 中川靖士, 森本雅美, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章, 横石道寛 :
重症筋無力症患者の術前3D画像による拡大胸腺摘出術後の予後予測の検討,
第29回日本呼吸器外科学会総会, 2012年5月. 森本雅美, 滝沢宏光, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
進行浸潤型胸腺腫に対するCAMP療法の有用性,
第29回日本呼吸器外科学会総会, 2012年5月. 近藤和也, 川原有貴, 高井チカ子, 藤田結衣, 大岩由香理, 滝沢宏光, 中川靖士, 梶浦耕一郎, 川上行奎, 吉田光輝, 監﨑孝一郎, 先山正二, 丹黒章 :
肺腺癌における遺伝子不安定性のマーカーとしてのヒストン蛋白γH2AXの発現,
第29回日本呼吸器外科学会総会, 2012年5月. 先山正二, 監﨑孝一郎, 鳥羽博明, 宇山攻, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺の再生・修復を目的とした胎生期肺組織移植,
第29回日本呼吸器外科学会総会, 2012年5月. 滝沢宏光, 近藤和也, 松岡永, 森本雅美, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
術前CTリンパ管造影と術中ICG蛍光法による肺癌センチネルリンパ節同定法の確立,
第29回日本呼吸器外科学会総会, 2012年5月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
《サージカルフォーラム》食道癌におけるGlasgow prognostic scoreの意義,
第112回日本外科学会定期学術集会, 2012年4月. 丹黒章, 中川美砂子, 湊拓也, 山本洋太, 古北由仁, 武知浩和 :
《ワークショップ》乳癌，食道癌におけるCT lymphography(CTLG)を用いたセンチネルリンパ節ナビゲーショ,
第112回日本外科学会定期学術集会, 2012年4月. 滝沢宏光, 中川靖士, 武知浩和, 森本雅美, 後藤正和, 中川美砂子, 梶浦耕一郎, 古北由仁, 山本洋太, 吉田光輝, 川上行奎, 丹黒章 :
副甲状腺腺腫摘出術後のテタニー症状出現に関わる因子の検討,
第40回中国四国甲状腺外科研究会, 2012年1月. 後藤正和, 丹黒章, 古北由仁, 森本雅美, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
左胸郭形成術後患者における縦隔鏡下食道切除術の経験,
第24回日本内視鏡外科学会総会, 2011年12月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
腹腔鏡下手術を施行したupside down stomachを呈する複合型巨大食道裂孔ヘルニアの1例,
第24回日本内視鏡外科学会総会, 2011年12月. 梶浦耕一郎, 先山正二, 鳥羽博明, 森本雅美, 湊拓也, 後藤正和, 古北由仁, 山本洋太, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
3回にわたる頚部縦隔胸腔ドレナージ術施行し救命しえた降下性壊死性縦隔炎の1例,
第73回日本臨床外科学会総会, 2011年11月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
Nissen術後の通過障害に対し再手術を施行した1例,
第73回日本臨床外科学会総会, 2011年11月. 後藤正和, 丹黒章, 古北由仁, 森本雅美, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
左胸郭形成術後の表在型食道癌に対して縦隔鏡下食道切除術を施行した1例,
第73回日本臨床外科学会総会, 2011年11月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
当科におけるcT4食道癌の治療成績,
第73回日本臨床外科学会総会, 2011年11月. 監﨑孝一郎, 先山正二, 鳥羽博明, 森本雅美, 梶浦耕一郎, 宇山攻, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
突発性と手術後気胸に対するフィブリン糊大量胸腔内注入療法の比較検討,
第73回日本臨床外科学会総会, 2011年11月. 梶浦耕一郎, 先山正二, 鳥羽博明, 宇山攻, 中川靖士, 吉田光輝, 滝沢宏光, 川上行奎, 監﨑孝一郎, 近藤和也, 丹黒章 :
胸腺腫摘出後に再生不良性貧血を発症した1例,
第52回日本肺癌学会総会, 2011年11月. 白石真理子, 近藤和也, 岩佐裕介, 藤田結衣, 大岩由香里, 高井チカ子, 滝沢宏光, 中川靖士, 鳥羽博明, 川上行奎, 梶浦耕一郎, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム酸塩に暴露したヒト肺癌におけるdsDNAの切断を修復するDNA修復遺伝子の異常の検討,
第52回日本肺癌学会総会, 2011年11月. 吉田光輝, 先山正二, 日野弘之, 森本雅美, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 近藤和也, 丹黒章 :
胸腔内の解剖学的破格を伴った肺癌手術症例の検討,
第52回日本肺癌学会総会, 2011年11月. 森本雅美, 滝沢宏光, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺腺癌手術検体を用いたCycleave-PCR法とPNA-LNA PCR-Clamp法のEGFR遺伝子変異測定結果の比較,
第52回日本肺癌学会総会, 2011年11月. 佐土原洋平, 鳥羽博明, 近藤和也, 梶浦耕一郎, 中川靖士, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍のFDG-PET/CT所見とHIF-1α，Glut-1，VEGFの発現との関連性,
第52回日本肺癌学会総会, 2011年11月. 山本洋太, 森本雅美, 西野豪志, 後藤正和, 湊拓也, 梶浦耕一郎, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
当科における女性食道扁平上皮癌の検討,
第49回日本癌治療学会学術集会, 2011年10月. 古北由仁, 高嶋美佳, 湊拓也, 山本洋太, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
当科における食道重複癌の治療経験,
第49回日本癌治療学会学術集会, 2011年10月. 西野豪志, 山本洋太, 後藤正和, 湊拓也, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
術前DFP療法が奏効し，病理学的CRが得られた大動脈浸潤高度進行胸部食道癌の一例,
第49回日本癌治療学会学術集会, 2011年10月. 後藤正和, 島田光生, 栗田信浩, 岩田貴, 佐藤宏彦, 西岡将規, 森本慎也, 吉川幸造, 宮谷知彦, 柏原秀也, 三上千絵, 宇都宮徹, 三宅秀則, 丹黒章 :
胃癌における悪性度指標としてAID (activation-induced cytidine deaminase)発現の意義,
JDDW2011(2011年度日本消化器関連学会週間), 2011年10月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
進行食道癌に対するweekly DOC+low dose FP療法の検討,
第64回日本胸部外科学会定期学術集会, 2011年10月. 山本洋太, 湊拓也, 梶浦耕一郎, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
食道扁平上皮癌に対する術前DFP療法(weekly DOC+low-dose FP療法)の有用性の検討,
第64回日本胸部外科学会定期学術集会, 2011年10月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺葉切除術後の残存肺の容積変化と術後呼吸機能についての検討,
第64回日本胸部外科学会定期学術集会, 2011年10月. 滝沢宏光, 鳥羽博明, 梶浦耕一郎, 森本雅美, 宇山攻, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
経気管支水溶性造影剤注入によるCTリンパ管造影-区域切除におけるSentinel node navigation surgeryに向けて,
第64回日本胸部外科学会定期学術集会, 2011年10月. 武知浩和, 高嶋美佳, 湊拓也, 梶浦耕一郎, 古北由仁, 山本洋太, 清家純一, 丹黒章 :
食道癌肉腫の1切除例,
第65回日本食道学会学術集会, 2011年9月. 古北由仁, 高嶋美佳, 湊拓也, 山本洋太, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
当科における食道重複癌の治療経験,
第65回日本食道学会学術集会, 2011年9月. 山本洋太, 高嶋美佳, 西野豪志, 湊拓也, 梶浦耕一郎, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
食道扁平上皮癌に対する術前DFP療法(weekly DOC+low-dose FP療法)の有用性の検討,
第65回日本食道学会学術集会, 2011年9月. 西野豪志, 山本洋太, 湊拓也, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
術前DFP療法が奏功し，病理学的CRを得られた大動脈浸潤高度進行胸部食道癌の一例,
第65回日本食道学会学術集会, 2011年9月. 湊拓也, 湯浅康弘, 池田真由美, 三崎万理子, 高嶋美佳, 古北由仁, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道亜全摘，胃管再建術における縫合不全の検討,
第65回日本食道学会学術集会, 2011年9月. 猪子拓人, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 都川美喜雄, 安野恵実子 :
格子状回路による生体インピーダンスパラメータ推定,
電気関係学会四国支部連合大会講演論文集, 237, 2011年9月.

(要約): 生体組織インピーダンス測定値に最小誤差で適合する二次元等価回路のパラメータ決定を行うために，皮下組織の層状構成を考慮し，かつ周波数依存性のないパラメータを要素とする回路構成を検討した．また生体組織を実測し，抵抗値および導電率の推定を行った．

今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する認識,
第19回日本乳癌学会学術総会, 439, 2011年9月. 今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する認識,
439, 2011年9月. 三木仁司, 丹黒章, 三谷弘, 日野直樹, 豊崎纏 :
徳島市乳がん検診からみた乳がん検診無料クーポン券の意義と課題,
第19回日本乳癌学会学術総会, 2011年9月. 山本裕, 園尾博司, 池田雅彦, 丹黒章, 辻尚志, 土井原博義, 加藤智栄, 笹三徳 :
アロマターゼ阻害剤耐性閉経後進行・再発乳癌に対する高用量トレミフェンの有効性と安全性の検討,
第19回日本乳癌学会学術総会, 2011年9月. 池田真由美, 中川美砂子, 宮本佳美, 三崎万理子, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
当科における高用量トレミフェン療法の位置づけ,
第19回日本乳癌学会学術総会, 2011年9月. 森本雅美, 中川美砂子, 三崎万理子, 池田真由美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
徳島県における乳癌地域連携の取り組み,
第19回日本乳癌学会学術総会, 2011年9月. 武知浩和, 中川美砂子, 宮本佳美, 池田真由美, 三崎万理子, 丹黒章 :
進行乳癌症例在宅療養推進に向けた当科の取り組み,
第19回日本乳癌学会学術総会, 2011年9月. 中川美砂子, 宮本佳美, 三崎万理子, 池田真由美, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
完遂率を高め寛解率向上をめざした術前化学療法臨床試験中間報告,
第19回日本乳癌学会学術総会, 2011年9月. 三崎万理子, 中川美砂子, 宮本佳美, 池田真由美, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
進行乳癌に対するS-1+Docetaxel術前補助化学療法臨床試験,
第19回日本乳癌学会学術総会, 2011年9月. 丹黒章 :
乳腺専門医のキャリアパスを考える-男性の立場から-,
第19回日本乳癌学会学術総会, 2011年9月. 宮本佳美, 池田真由美, 三崎万理子, 中川美砂子, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
乳癌術後乳蘼廔の2例,
第19回日本乳癌学会学術総会, 2011年9月. 高嶋美佳, 池田真由美, 三崎万理子, 湊拓也, 山本洋太, 古北由仁, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
周術期に脳転移による脳ヘルニアを発症した1例,
第66回日本消化器外科学会総会, 2011年7月. 湊拓也, 湯浅康弘, 池田真由美, 三崎万理子, 高嶋美佳, 古北由仁, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道亜全摘，胃管再建術における縫合不全の検討,
第66回日本消化器外科学会総会, 2011年7月. 古北由仁, 三崎万理子, 池田真由美, 高嶋美佳, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
当科における巨大食道裂孔ヘルニアい対する腹腔鏡下手術,
第66回日本消化器外科学会総会, 2011年7月. 丹黒章 :
進行食道癌に対する術前化学療法の効果と副作用対策 -消化器不定愁訴に対する漢方薬の有用性-,
第66回日本消化器外科学会総会, 2011年7月. 山本洋太, 高嶋美佳, 湊拓也, 古北由仁, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道扁平上皮癌に対する術前DFP療法の有用性に関する検討,
第66回日本消化器外科学会総会, 2011年7月. 鳥羽博明, 先山正二, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
自家蛍光気管支鏡(SAFE-3000/AFI)の同時使用経験,
第34回日本呼吸器内視鏡学会学術集会, 2011年6月. 梶浦耕一郎, 鳥羽博明, 先山正二, 高嶋美佳, 湊拓也, 宇山攻, 滝沢宏光, 監﨑孝一郎, 川上行奎, 近藤和也, 丹黒章 :
当科におけるVBN併用極細径気管支鏡下肺生検の成績,
第34回日本呼吸器内視鏡学会学術集会, 2011年6月. 古北由仁, 高嶋美佳, 湊拓也, 山本洋太, 武知浩和, 丹黒章 :
当科における食道癌に対する初回治療としてのweekly DOC+low dose FP療法の検討,
第111回日本外科学会定期学術集会, 2011年5月. 山本洋太, 山井礼道, 湊拓也, 古北由仁, 湯浅康弘, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道癌治療におけるHER蛋白発現と治療効果・予後との関連の検討,
第111回日本外科学会定期学術集会, 2011年5月. 宇山攻, 先山正二, 鳥羽博明, 吉田光輝, 監﨑孝一郎, 丹黒章 :
胎仔肺移植による肺気腫自然発症モデルマウス肺修復の試み,
第111回日本外科学会定期学術集会, 2011年5月. 滝沢宏光, 近藤和也, 鳥羽博明, 梶浦耕一郎, 高嶋美佳, 湊拓也, 宇山攻, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
経気管支水溶性造影剤注入によるCTリンパ管造影-区域切除における術前センチネル,
第111回日本外科学会定期学術集会, 2011年5月. 丹黒章 :
医療安全と地域医療崩壊の狭間で地方大学外科教室の担う役割,
第111回日本外科学会定期学術集会, 2011年5月. 武知浩和, 池田真由美, 三崎万理子, 高嶋美佳, 兼松美幸, 湊拓也, 中川美砂子, 梶浦耕一郎, 古北由仁, 山本洋太, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
女性外科医の働きやすい現場を目指して,
第111回日本外科学会定期学術集会, 2011年5月. 兼松美幸, 滝沢宏光, 近藤和也, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
NSCLC完全切除例に対するS-1療法とweekly PTX+CBDCA併用療法の比較検討,
第28回日本呼吸器外科学会総会, 2011年5月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺葉切除術前後における肺の容積変化についての検討,
第28回日本呼吸器外科学会総会, 2011年5月. 高嶋美佳, 滝沢宏光, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺癌との鑑別が困難であった結節性リンパ組織過形成の2切除例,
第28回日本呼吸器外科学会総会, 2011年5月. 梶浦耕一郎, 高嶋美佳, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 中川靖士, 川上行奎, 宇山攻, 先山正二, 近藤和也, 丹黒章 :
肺癌手術時の胸腔内洗浄細胞診陽性症例の検討,
第28回日本呼吸器外科学会総会, 2011年5月. 監﨑孝一郎, 先山正二, 鳥羽博明, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気胸に対するフィブリン糊大量胸腔内注入療法の検討,
第28回日本呼吸器外科学会総会, 2011年5月. 鳥羽博明, 先山正二, 高嶋美佳, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
肺癌術後のフォローアップにPET/CTは有用か,
第28回日本呼吸器外科学会総会, 2011年5月. 近藤和也, 名村寿章, 藤田結衣, 高井チカ子, 大岩由香理, 滝沢宏光, 中川靖士, 鳥羽博明, 梶浦耕一郎, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍におけるDNA修復遺伝子MGMTのDNAメチル化と蛋白発現,
第28回日本呼吸器外科学会総会, 2011年5月. 丹黒章 :
乳癌手術において整容性と根治性を両立するための工夫,
第54回日本形成外科学会総会・学術集会, 2011年4月. 安倍吉郎, 橋本一郎, 中西秀樹, 湊拓也, 丹黒章, 一宮誠 :
難治性唾液瘻に対し大腿筋膜移植と大胸筋皮弁を組み合わせた新しい閉鎖法,
第16回形成外科手術手技研究会, 2011年2月. 武知浩和, 高嶋美佳, 兼松美幸, 湊拓也, 梶浦耕一郎, 古北由仁, 山本洋太, 清家純一, 丹黒章 :
バセドウ病を合併した食道癌肉腫の1例,
第72回日本臨床外科学会総会, 2010年11月. 山本洋太, 高嶋美佳, 兼松美幸, 湊拓也, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
当科における女性食道癌の検討,
第72回日本臨床外科学会総会, 2010年11月. 湊拓也, 山本洋太, 高嶋美佳, 兼松美幸, 古北由仁, 武知浩和, 丹黒章 :
PET-CTにて腹部リンパ節偽陽性を示した食道腺扁平上皮癌の1切除例,
第72回日本臨床外科学会総会, 2010年11月. 古北由仁, 高嶋美佳, 兼松美幸, 湊拓也, 山本洋太, 武知浩和, 丹黒章 :
食道良性疾患に対する腹腔鏡下手術の検討,
第72回日本臨床外科学会総会, 2010年11月. 丹黒章, 中川美砂子, 湊拓也, 山本洋太, 武知浩和, 川上行奎 :
乳癌治療における術前3D-CT lymphography(CTLG)ナビゲーション,
第72回日本臨床外科学会総会, 2010年11月. 笠原善郎, 辻一郎, 大内憲明, 東野英利子, 横江隆夫, 苛原稔, 丹黒章 :
乳癌検診の不利益:マンモグラフィ検診偽陽性例の実態調査,
第20回日本乳癌検診学会総会, 2010年11月. 滝沢宏光, 近藤和也, 鳥羽博明, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
呼吸器領域におけるレーザー診断・治療の現況と展望,
第31回日本レーザー医学会総会, 2010年11月. 藤田結衣, 近藤和也, Hamed Ali Abdellah Khalil, 名村寿章, 仙波義貴, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム工場従事者におけるlung cancer susceptibilityの解析,
第51回日本肺癌学会総会, 2010年11月. 近藤和也, Hamed Ali Abdellah Khalil, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム酸塩に暴露した労働者に発生した肺癌における癌関連遺伝子の異常,
第51回日本肺癌学会総会, 2010年11月. 岩田貴, 島田光生, 栗田信浩, 西岡将規, 丹黒章, 沖津宏, 藤野良三, 安藤道夫, 惣中康秀 :
大腸がんに対する鏡視下手術の標準化と普及における問題点と対策:地方からの提言,
第48回日本癌治療学会学術集会, 2010年10月. 鳥羽博明, 先山正二, 監﨑孝一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胎仔肺組織移植により移植したグラフト内でのTTF-1発現の検討,
第63回日本胸部外科学会定期学術集会, 2010年10月. 滝沢宏光, Khalil Harmed Abdellah, 近藤和也, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 柿内聡司, 曽根三郎, 丹黒章 :
5-アミノレブリン酸を用いた胸膜悪性腫瘍の蛍光診断,
第63回日本胸部外科学会定期学術集会, 2010年10月. 古北由仁, 高嶋美佳, 兼松美幸, 湊拓也, 山本洋太, 梶浦耕一郎, 武知浩和, 丹黒章, 津田恵, 岸本大輝, 金山博臣 :
腹腔鏡下に食道裂孔ヘルニアおよび左腎癌に対して一期的手術を施行した1例,
第23回日本内視鏡外科学会総会, 2010年10月. 服部圭悟, 猪子拓人, 小中信典, 木内陽介, 芥川正武, 森本忠興, 丹黒章, 岡﨑憲二, 都川美喜雄, 安野恵実子 :
生体インピーダンスパラメータ推定に関する研究,
電気関係学会四国支部連合大会講演論文集, 197, 2010年9月. 近藤和也, ハーメド・カーリル・アリアブデラ, 名村寿章, 仙波義貴, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム工場労働者の肺がんにおける癌抑制遺伝子のDNAメチル化,
第69回日本癌学会学術総会, 2010年9月. 武知浩和, 清家純一, 高嶋美佳, 兼松美幸, 古北由仁, 山本洋太, 丹黒章 :
当科における食道癌終末期におけるベストサポーティブケア,
第64回日本食道学会学術集会, 2010年8月. 山本洋太, 高嶋美佳, 兼松美幸, 古北由仁, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
胸部食道癌に対する術前DOC/5-FU/CDDP併用療法(DFP療法)の有用性の検討,
第64回日本食道学会学術集会, 2010年8月. 清家純一, 丹黒章, 森本雅美, 兼松美幸, 井上聖也, 藤原聡史, 古北由仁, 山本洋太, 武知浩和 :
当科における縦隔鏡下食道切除術の検討,
第65回日本消化器外科学会総会, 2010年7月. 井上聖也, 兼松美幸, 藤原聡史, 古北由仁, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道癌Primary therapyの効果判定におけるPET-CTの有用性,
第65回日本消化器外科学会総会, 2010年7月. 山本洋太, 古北由仁, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
胸部食道癌に対する術前・術後化学療法の有用性に関する検討,
第65回日本消化器外科学会総会, 2010年7月. 兼松美幸, 高嶋美佳, 森本雅美, 井上聖也, 藤原聡史, 山本洋太, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
術前化学療法が著効し，喉頭温存術が可能となった広範囲表在食道癌の一例,
第65回日本消化器外科学会総会, 2010年7月. 高嶋美佳, 山本洋太, 古北由仁, 山井礼道, 武知浩和, 清家純一, 丹黒章 :
2家系で同胞発生した食道癌4例の検討,
第65回日本消化器外科学会総会, 2010年7月. 古北由仁, 兼松美幸, 森本雅美, 井上聖也, 藤原聡史, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
当科における進行食道癌に対するDocetaxel/5-FU/CDDP併用化学療法の治療成績,
第65回日本消化器外科学会総会, 2010年7月. 高橋雅子, 笹三徳, 本田純子, 長尾妙子, 吉良美砂子, 日下真理子, 住友いく子, 西村理砂, 丹黒章 :
アロマターゼインヒビター投与開始時での血清E2モニターの必要性,
第18回日本乳癌学会学術総会, 2010年6月. 井上聖也, 兼松美幸, 岡﨑憲二, 中川美砂子, 長尾妙子, 丹黒章 :
閉経後乳癌における術前ホルモン療法の検討,
第18回日本乳癌学会学術総会, 2010年6月. 吉良美砂子, 長尾妙子, 森本雅美, 兼松美幸, 井上聖也, 岡﨑憲二, 丹黒章, 笹三徳, 坂東良美, 畑田卓也 :
Triple negative乳癌(TNBC)の組織学的特徴-バイオマーカーによる亜分類確立を目指して-,
第18回日本乳癌学会学術総会, 2010年6月. 森本雅美, 吉良美砂子, 長尾妙子, 兼松美幸, 井上聖也, 岡﨑憲二, 丹黒章, 畑田卓也 :
当院における乳癌癌性髄膜炎の5例,
第18回日本乳癌学会学術総会, 2010年6月. 滝沢宏光, Khalil Harmed Abdellah, 近藤和也, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 柿内聡司, 曽根三郎, 丹黒章 :
5-アミノレブリン酸を用いた胸膜悪性腫瘍の蛍光診断,
第20回日本光線力学学会学術講演会, 2010年6月. 河南真吾, 監﨑孝一郎, 鳥羽博明, 森本雅美, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
巨大気腫性肺嚢胞に対して嚢胞内ドレナージ後に気管支塞栓術+フィブリン糊嚢胞内注入により治療した1例,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 鳥羽博明, 先山正二, 兼松美幸, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
CT所見から見た小型末梢肺病変に対する極細径気管支鏡を用いたCTガイド下肺生検の適応の再構築,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 兼松美幸, 鳥羽博明, 先山正二, 三好孝典, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
小型末梢肺病変に対するVBN併用下CTガイド下気管支鏡下コイルマーキング,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. Abdellah Hamed, 鳥羽博明, 先山正二, 山本良, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
Holter ECG Monitoring of Sympathovagal Fluctuations During Bronchoscopy,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
当科におけるmulti-modality methodを用いた気管支鏡検査の教育方法,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 森本雅美, 鳥羽博明, 先山正二, 兼松美幸, 藤原聡史, 井上聖也, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
多中心性に発生したと考えられた同時性多発胸腺腫の1例,
第27回日本呼吸器外科学会総会, 2010年5月. 兼松美幸, 高嶋美佳, 森本雅美, 井上聖也, 藤原聡史, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
非小細胞肺癌に対する術後補助療法としてのweekly paclitaxel+carboplatin(wTJ)併用療法の検討,
第27回日本呼吸器外科学会総会, 2010年5月. 川田祐子, 滝沢宏光, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 近藤和也, 島田光生, 丹黒章 :
先天性心膜欠損を合併した肺嚢胞症の一切除例,
第27回日本呼吸器外科学会総会, 2010年5月. 高嶋美佳, 鳥羽博明, 監﨑孝一郎, 森本雅美, 兼松美幸, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
当科における肺動静脈瘻手術症例の臨床的検討,
第27回日本呼吸器外科学会総会, 2010年5月. 鳥羽博明, 近藤和也, 滝沢宏光, 高嶋美佳, 森本雅美, 兼松美幸, 中川靖士, 監﨑孝一郎, 先山正二, 丹黒章 :
肺癌術後再発症例の検討,
第27回日本呼吸器外科学会総会, 2010年5月. 澤田徹, 滝沢宏光, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
CT画像を用いた右上葉切除術前および術後の肺容積の変化についての検討,
第27回日本呼吸器外科学会総会, 2010年5月. 監﨑孝一郎, 生島仁史, 近藤和也, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 丹黒章 :
原発性肺癌Ⅰ期における消極的肺部分切除と定位放射線治療との比較,
第27回日本呼吸器外科学会総会, 2010年5月. 先山正二, 監﨑孝一郎, 鳥羽博明, Khasag Narmisheekh, 宇山攻, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
豚を用いた胎生期肺組織移植の実験的検討-ラットで得られた知見との比較を含めて-,
第27回日本呼吸器外科学会総会, 2010年5月. 近藤和也, 張真弓, 田所由紀子, 仙波義貴, 中川靖士, 滝沢宏光, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍の発生におけるDNA修復遺伝子MGMTの関連性,
第27回日本呼吸器外科学会総会, 2010年5月. 山井礼道, 山本洋太, 湯浅康弘, 吉田卓弘, 清家純一, 島田光生, 丹黒章 :
食道癌腹膜転移モデルを用いた植物化学サプリメント併用化学療法の検討,
第110回日本外科学会定期学術集会, 2010年4月. 森本雅美, 吉良美砂子, 兼松美幸, 井上聖也, 藤原聡史, 古北由仁, 山本洋太, 中川靖士, 滝沢宏光, 丹黒章 :
甲状腺未分化癌に対する経口フッ化ピリミジン系抗癌剤による補助療法の可能性,
第110回日本外科学会定期学術集会, 2010年4月. 山本洋太, 井上聖也, 藤原聡史, 古北由仁, 湯浅康弘, 山井礼道, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
HER-蛋白発現は，食道扁平上皮癌手術症例における再発リスク因子となりうる,
第110回日本外科学会定期学術集会, 2010年4月. 中川美砂子, 兼松美幸, 森本雅美, 岡﨑憲二, 長尾妙子, 丹黒章 :
CTリンパ管造影におけるセンチネルリンパ節の転移診断,
第110回日本外科学会定期学術集会, 2010年4月. Koichiro Kenzaki, Shoji Sakiyama, 宇山攻, Hiroaki Toba, Yasushi Nakagawa, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Sex-mismatchを用いたラット胎仔肺移植モデルのドナー細胞の組織学的検討,
第110回日本外科学会定期学術集会, Apr. 2010. 中川靖士, 近藤和也, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺癌44例の検討,
第110回日本外科学会定期学術集会, 2010年4月. 滝沢宏光, 近藤和也, Abdellah Khalil Hamed, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 丹黒章 :
光感受性物質を用いた胸膜悪性腫瘍の蛍光診断-SCIDマウスヒト肺癌胸膜播種モデルを用いた実験-,
第110回日本外科学会定期学術集会, 2010年4月. 先山正二, 監﨑孝一郎, 鳥羽博明, Khasag Narmisheekh, 宇山攻, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
豚を用いた胎生期肺組織移植の実験的検討,
第110回日本外科学会定期学術集会, 2010年4月. Narmisheekh Khasag, 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
肺癌手術における呼気中一酸化および二酸化炭素モニタリング,
第110回日本外科学会定期学術集会, 2010年4月. 宇山攻, 先山正二, 松岡永, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
非結核性抗酸菌症手術症例の検討,
第110回日本外科学会定期学術集会, 2010年4月. 服部圭吾, 小谷亮介, 木内陽介, 芥川正武, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子 :
生体インピーダンスパラメータ推定に関する研究,
電気関係学会四国支部連合大会講演論文集, 240, 2009年9月. 小谷亮介, 服部圭吾, 木内陽介, 芥川正武, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子 :
生体インピーダンス計測でのガード電極効果の検証,
電気関係学会四国支部連合大会講演論文集, 239, 2009年9月. 渕上輝彦, 阿部晃治, 陣内自治, 高岡司, 田村公一, 武田憲昭, 丹黒章 :
頭頸部癌化学放射線療法における経皮内視鏡胃瘻造設術(PEG)の有用性,
第239回徳島医学会学術集会, 2009年8月. 平田容子, 松村晃子, 山田静恵, 山田静恵, 宇野和美, 山本智美, 武知浩和, 長尾妙子, 清家純一, 保坂利男, 丹黒章, 中屋豊 :
乳癌化学療法中に穿孔性腹膜炎をきたした一例,
第12回日本病態栄養学会学術集会, 2009年1月. 小谷亮介, 櫟田英広, 木内陽介, 芥川正武, 森本忠興, 丹黒章, 岡崎憲二, 安野恵実子 :
食塩水ファントムを用いたガード電極効果の検証,
電気関係学会四国支部連合大会講演論文集, 239, 2008年9月. 櫟田英広, 小谷亮介, 木内陽介, 芥川正武, 岡崎憲二, 丹黒章, 森本忠興, 安野恵実子 :
ファントムを用いた生体インピーダンス計測装置の検証,
電気関係学会四国支部連合大会講演論文集, 240, 2008年9月. 森口博基, 丹黒章, 森川富昭, 近藤佐地子, 岡田達也 :
Web上の協力による外科手術のためのインフォームド・コンセント用3DCGアニメーションの作成,
医療情報学連合大会論文集27回, 415-416, 2007年11月. Ikeda Yuichi, Sato Yasuhiro, Ichida Teruhiro, Emiko Yasuno, Yohsuke Kinouchi, Okazaki Kenji, Akira Tangoku and Tadaoki Morimoto :
Development of Noninvasive Bio-impedance Measuring Method for Breast Cancer Diagnosis,
Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 398, Sep. 2007. 櫟田英広, 池田祐一, 佐藤康弘, 木内陽介, 岡崎憲二, 丹黒章, 森本忠興, 安野恵実子 :
食塩水ファントムを用いた生体インピーダンス計測装置の検証,
電気関係学会四国支部連合大会講演論文集, 221, 2007年9月. 佐藤康弘, 池田祐一, 櫟田英広, 木内陽介, 森本忠興, 丹黒章, 岡崎憲二, 安野恵実子 :
生体インピーダンス計測時の組織内電流計測時の組織内電流分布解析,
電気関係学会四国支部連合大会講演論文集, 220, 2007年9月. 湊拓也, 沖津宏, 田中麻美, 山村陽子, 片山和久, 木村秀, 坂田章聖, 山下理子, 藤井義幸, 丹黒章, 伊藤孝司, 伊崎俊介, 高野正志 :
TS-1の術前2週投与によりほぼCRがえられた進行胃癌の1症例,
第82回中国四国外科学会総会, 2007年9月. 森本有理砂, 安野恵実子, 木内陽介, 森本忠興, 丹黒章, 大嶺裕賢 :
局所EITの空間分解能に関する研究,
電気関係学会四国支部連合大会講演論文集, 223, 2005年9月. 辻川哲也, 上野淳二, 湊雅子, 尾﨑享祐, 生島仁史, 丹黒章 :
CT volume dataを用いたセンチネルリンパ節のナビゲーション診断法,
2005年9月. 三好孝典, 近藤和也, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二, 丹黒章 :
OR8-3 当科における光線力療法の治療経験ーporfimer sodiumからtalaporfin sodiumへー,
第128回日本呼吸器内視鏡学会総会, 2005年6月. 三好孝典, 近藤和也, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二, 丹黒章 :
O-090 抹消型微小肺癌に対する術前マーキングによる縮小手術の可能性,
第22回日本呼吸器外科学会総会, Vol.1997, No.3, 201, 2005年6月. 長島由紀子, 丹黒章, 山本滋, 岡正朗, 菅一能 :
乳房温存療法における鏡視下郭清術,
手術, Vol.59, No.3, 359-363, 2005年. 河岡徹, 上野富雄, 山本光太郎, 矢原昇, 硲彰一, 丹黒章, 岡正朗 :
Stage 4 膵臓に対する免疫療法を中心とした多角的治療選択,
第58回日本消化器外科学会, 2003年7月. 山本光太郎, 上野富雄, 矢原昇, 河岡徹, 年光宏明, 丹黒章, 岡正朗 :
シンポジウム:切除適応膵癌に対する複合免疫療法による治療戦略,
第34回日本膵臓学会, 2003年7月. 山本光太郎, 上野富雄, 矢原昇, 河岡徹, 丹黒章, 佐藤恭悟, 岡正朗 :
パネルディスカッション:膵癌に対する癌抗原ペプチドワクチン療法の可能性,
第58回日本消化器外科学会, 2003年7月. 丹黒章, 吉野茂文, 阿部俊弘, 林秀知, 上野隆, 岡正朗 :
シンポジウム:胸部食道癌に対する縦隔鏡下食道(Mediastinoscope Assited Transhiatal Esophagectomu : Mathe)の長期成績,
第103回日本外科学会, 2003年6月. 山本光太郎, 上野富雄, 矢原昇, 河岡徹, 年光宏明, 硲彰一, 丹黒章, 岡正朗 :
膵歴に対する手術適応の再考と新たな複合免疫療法,
第103回日本外科学会, 2003年6月. 上野隆, 佐々木功典, 丹黒章, 吉野茂文, 岡正朗 :
食道表在癌の染色体異常に基づくリンパ節転移予測,
第103回日本外科学会, 2003年6月. 硲彰一, 荒木厚博, 的場勝弘, 丹黒章, 岡正朗 :
シンポジウム:潰瘍性大腸炎ならびにクローン病に対する手術のタイミングと術式の選択,
第39回日本腹部救急医学会, 2003年3月. 丹黒章, 吉野茂文, 阿部俊弘, 森田克彦, 上野隆, 岡正朗 :
シンポジウム:胸部食道癌に対する縦隔鏡下食道 (Mediastinoscope Assited Transhiatal Esophagectomu : Mathe),
第11回クリニカルビデオフォーラム, 2003年1月. 長島由紀子, 丹黒章, 山本滋, 岡正朗 :
パネルディスカッション:乳房温存療法における鏡視下郭清術,
第103回日本外科学会, 2003年. 阿部俊弘, 上野隆, 丹黒章, 吉野茂文, 林秀知, 佐藤智光, 岡正朗 :
パネルディスカッション:CGH法を用いた進行食道癌の染色体異常に基づく転移および再発予後予測,
第55回日本胸部外科学会, 2002年9月.

研究会・報告書

井上聖也, 吉田卓弘, 後藤正和, 藤原聡史, 乾友浩, 坂本晋一, 宮本直輝, 青山万理子, 鳥羽博明, 丹黒章, 滝沢宏光 :
安全な食道再建のわれわれの工夫,
第5回徳島外科医会, 2022年2月. 井上聖也, 吉田卓弘, 後藤正和, 藤原聡史, 乾友浩, 坂本晋一, 宮本直輝, 青山万理子, 丹黒章, 鳥羽博明, 滝沢宏光 :
食道切除後再建術における最近の取り組み-ICG血流評価法とCollard変法の有用性-,
第42回四国食道疾患研究会(WEB開催), 2022年2月. 藤原聡史, 吉田卓弘, 後藤正和, 井上聖也, 乾友浩, 坂本晋一, 宮本直輝, 青山万理子, 丹黒章, 鳥羽博明, 滝沢宏光 :
肺癌を合併した食道癌に対し，一期的手術を施行した3例の検討,
第42回四国食道疾患研究会(WEB開催), 2022年2月. 庄野隆志, 青山万理子, 南城和正, 山本清成, 牧秀則, 乾友浩, 坂本晋一, 小林智子, 中村信元, 滝沢宏光, 丹黒章 :
アブスコパル効果を示した甲状腺原発形質細胞腫の1例,
第49回中国四国甲状腺外科研究会(ハイブリッド開催), 2021年2月. 青山万理子, 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 乾友浩, 宮本直輝, 坂本晋一, 丹黒章 :
低用量レンバチニブで長期PRを維持できている再発甲状腺乳頭癌の1例,
第49回中国四国甲状腺外科研究会(ハイブリッド開催), 2021年2月. 宮本直輝, 吉田光輝, 大塚憲司, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 西岡安彦, 滝沢宏光, 丹黒章 :
胸腔鏡下に確定診断を得たCalcifying fibrous tumorの1例,
第4回徳島外科医会, 2021年2月. 坂本晋一, 滝沢宏光, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
左B1+2転位気管支とV1+2の走行異常を認める左下葉肺癌の一切除例,
第4回徳島外科医会, 2021年2月. 庄野隆志, 滝沢宏光, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 吉田光輝, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
網膜芽細胞腫治療後に縦隔鏡に発生した平滑筋肉腫の一例,
第4回徳島外科医会, 2021年2月. 牧秀則, 井上聖也, 南城和正, 庄野隆志, 後藤正和, 西野豪志, 吉田卓弘, 丹黒章 :
巨大食道裂孔ヘルニアを伴う特発性食道破裂の一例,
第4回徳島外科医会, 2021年2月. 南城和正, 井上聖也, 牧秀則, 庄野隆志, 西野豪志, 後藤正和, 吉田卓弘, 丹黒章 :
食道癌術後に門脈ガス血症・腸管気腫症を発症した1例,
第4回徳島外科医会, 2021年2月. 乾友浩, 井上寛章, 笹聡一郎, 青山万理子, 奥村和正, 鳥羽博明, 滝沢宏光, 丹黒章 :
トラスツズマブ+ペルツズマブ投与にて重度のinfusion reactionを認めたが再投与可能であった1例,
第4回徳島外科医会, 2021年2月. 笹聡一郎, 井上寛章, 奥村和正, 青山万理子, 乾友浩, 鳥羽博明, 丹黒章 :
当施設におけるステレオガイド下マンモトーム生検の検討,
第4回徳島外科医会, 2021年2月. 山本清成, 青山万理子, 滝沢宏光, 南城和正, 庄野隆志, 牧秀則, 丹黒章 :
右心房転移をきたした甲状腺未分化癌の1例,
第4回徳島外科医会, 2021年2月. 牧秀則, 井上聖也, 南城和正, 後藤正和, 西野豪志, 吉田卓弘, 丹黒章 :
巨大食道裂孔ヘルニアを伴った特発性食道破裂の一例,
第41回四国食道疾患研究会(Web開催), 2021年1月. 山本清成, 西野豪志, 庄野隆志, 南城和正, 牧秀則, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 井上聖也, 後藤正和, 吉田卓弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
気管分岐部狭窄を伴う進行食道癌に対する集学的治療の経験,
第261回徳島医学会学術集会(Web配信), 2020年8月. 庄野隆志, 西野豪志, 南城和正, 山本清成, 牧秀則, 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 井上聖也, 後藤正和, 奥村和正, 吉田卓弘, 丹黒章 :
乳癌術後20年目に食道転移をきたした1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 乾友浩, 笹聡一郎, 青山万理子, 井上寛章, 奥村和正, 丹黒章 :
乳癌に対するCNB後にNeedle tract seedingを認めた1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 牧秀則, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 松本大資, 髙嶋美佳, 河北直也, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
微小肺病変に対して術中Cone-beam CT併用気管支鏡下コイルマーキングが有用であった1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 鳥羽博明, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 牧秀則, 乾友浩, 坂本晋一, 宮本直輝, 笹聡一郎, 青山万理子, 井上寛章, 髙嶋美佳, 松本大資, 井上聖也, 河北直也, 後藤正和, 西野豪志, 奥村和正, 吉田卓弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
より良いがんの地域連携体制構築のための取り組み,
第261回徳島医学会学術集会(Web配信), 2020年8月. 丹黒章 :
新たな手術手技開発を目指した臨床解剖学,
2020年8月. 溝渕海, 青山万理子, 滝沢宏光, 竹原恵美, 河北直也, 坪井光弘, 丹黒章 :
巨大甲状腺腫によって高度の気管狭窄を生じた1症例,
第3回徳島外科医会, 2020年2月. 宮本直輝, 井上聖也, 吉田卓弘, 西野豪志, 溝渕海, 竹原恵美, 青山万理子, 森本雅美, 武知浩和, 丹黒章 :
進行食道癌の術前診断において縦隔リンパ節転移と診断された迷走神経鞘腫の1例,
第3回徳島外科医会, 2020年2月. 滝沢宏光, 鳥羽博明, 松本大資, 高嶋美佳, 竹原恵美, 宮本直輝, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
チームで行う3Dモデルを用いたロボット支援胸腔鏡下肺葉切除のシミュレーション,
第34回四国内視鏡外科研究会, 2020年2月. 青山万理子, 滝沢宏光, 溝渕海, 竹原恵美, 坪井光弘, 丹黒章 :
自家蛍光による副甲状腺の同定-励起光による自家蛍光の変化に注目して-,
第48回中国四国甲状腺外科研究会, 2020年2月. 坪井光弘, 青山万理子, 滝沢宏光, 溝渕海, 竹原恵美, 丹黒章 :
甲状腺がん再発症例の検討,
第48回中国四国甲状腺外科研究会, 2020年2月. 溝渕海, 坪井光弘, 竹原恵美, 宮本直輝, 青山万理子, 滝沢宏光, 丹黒章 :
上肢の知覚障害で発症した甲状腺乳頭癌脳転移の1例,
第48回中国四国甲状腺外科研究会, 2020年2月. 竹原恵美, 青山万理子, 滝沢宏光, 溝渕海, 河北直也, 坪井光弘, 丹黒章 :
巨大甲状腺腫によって高度の気管狭窄を生じた1症例,
第48回中国四国甲状腺外科研究会, 2020年2月. 宮本直輝, 吉田卓弘, 西野豪志, 井上聖也, 竹原恵美, 溝渕海, 丹黒章 :
進行食道癌の術前診断において縦隔リンパ節転移と診断された迷走神経鞘腫の1例,
第40回四国食道疾患研究会, 2020年2月. 溝渕海, 吉田卓弘, 西野豪志, 井上聖也, 竹原恵美, 宮本直輝, 丹黒章 :
食道閉鎖症に対する再建結腸に発生した結腸癌の1切除例,
第40回四国食道疾患研究会, 2020年2月. 井上聖也, 吉田卓弘, 西野豪志, 宮本直輝, 竹原恵美, 溝渕海, 丹黒章 :
当院の食道癌集学的チーム医療におけるNSTの役割,
第40回四国食道疾患研究会, 2020年2月. 丹黒章 :
食道をくり抜く-縦隔鏡下食道切除術-根治性と低侵襲性の両立,
第6回縦隔アプローチ食道癌根治術研究会, 2019年7月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
触知困難小型肺病変をコイルと色素を用いたマーキング法で切除した1例,
第33回四国内視鏡外科研究会, 2019年2月. 坪井光弘, 青山万理子, 滝沢宏光, 丹黒章 :
内視鏡下甲状腺外科手術における反回神経，上咽頭神経外枝の温存,
第47回中国四国甲状腺外科研究会, 2019年2月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
当科で経験した三次性副甲状腺機能亢進症の2症例,
第47回中国四国甲状腺外科研究会, 2019年2月. 池内真由美, 森本雅美, 笹聡一郎, 兼松美幸, 鳥羽博明, 武知浩和, 丹黒章 :
検診で指摘され得なかった腋窩副乳癌の1例,
第2回徳島外科医会, 2019年2月. 兼松美幸, 笹聡一郎, 池内真由美, 森本雅美, 鳥羽博明, 武知浩和, 丹黒章 :
乳腺原発悪性リンパ腫の1例,
第2回徳島外科医会, 2019年2月. 鈴木恵美, 高嶋美佳, 鳥羽博明, 松本大資, 森本雅美, 河北直也, 澤田徹, 坪井光弘, 武知浩和, 川上行奎, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
放射線皮膚潰瘍・胸骨骨髄炎に対し広汎骨性胸郭切除を行った乳癌再発の1例,
第2回徳島外科医会, 2019年2月. 山田亮, 松本大資, 高嶋美佳, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
術前化学放射線療法後Transmanubrial approach(TMA)で完全切除が可能であったPancoast腫瘍の1例,
第2回徳島外科医会, 2019年2月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
拡大胸腺摘出術における術式の比較検討,
第38回日本胸腺研究会, 2019年2月. 澤田徹, 近藤和也, 松井尚子, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 丹黒章 :
当院におけるMGに対する拡大胸腺摘出術後の予後成績,
第38回日本胸腺研究会, 2019年2月. 西野豪志, 吉田卓弘, 井上聖也, 鈴木恵美, 山田亮, 笹聡一郎, 後藤正和, 武知浩和, 丹黒章 :
食道癌に対する縦隔鏡下食道癌根治術∼縦隔鏡操作と経裂孔操作の連携による縦隔リンパ節郭清の工夫∼,
第39回四国食道疾患研究会, 2019年1月. 井上聖也, 吉田卓弘, 西野豪志, 鈴木恵美, 山田亮, 笹聡一郎, 後藤正和, 武知浩和, 丹黒章 :
術後乳糜瘻に対する鼠径リンパ節アプローチによるリンパ管造影の有用性の検討,
第39回四国食道疾患研究会, 2019年1月. 一宮由貴, 松岡由江, 三木幸代, 森本雅美, 武知浩和, 丹黒章 :
若年乳がん患者の意思決定支援∼がん看護専門看護師の実践を振り返って∼,
第82回徳島乳腺研究会, 2018年10月. 武知浩和, 一宮由貴, 松岡由江, 三木幸代, 森本雅美, 鳥羽博明, 笹聡一郎, 池内真由美, 兼松美幸, 吉田卓弘, 丹黒章 :
若年乳癌患者に対する治療時における「がん看護専門看護師」を支えたチーム医療,
第82回徳島乳腺研究会, 2018年10月. 池内真由美, 森本雅美, 中川美砂子, 鳥羽博明, 武知浩和, 丹黒章 :
検診で指摘され得なかった腋窩副乳癌の1例,
第82回徳島乳腺研究会, 2018年10月. 青山万理子, 滝沢宏光, 坪井光弘, 丹黒章 :
FDG-PET/CTで発見された甲状腺異常集積症例の検討,
第46回中国四国甲状腺外科研究会, 2018年3月. 坪井光弘, 青山万理子, 滝沢宏光, 吉田卓弘, 丹黒章 :
気管食道狭窄を来した甲状腺原発悪性リンパ腫の1例,
第46回中国四国甲状腺外科研究会, 2018年3月. 西野豪志, 吉田卓弘, 後藤正和, 井上聖也, 青山万理子, 行重佐和香, 森本雅美, 武知浩和, 丹黒章 :
縦隔鏡下食道癌根治術を目指したラーニングステップとしての縦隔鏡・胸腔鏡ハイブリッド手術,
第38回四国食道疾患研究会, 2018年2月. Masakazu Goto, Takahiro Yoshida, Takeshi Nishino, Seiya Inoue, 青山万理子, 行重佐和香, 森本雅美, Hirokazu Takechi and Akira Tangoku :
縦隔鏡下食道切除術における経裂孔的アプローチに必要な解剖,
第38回四国食道疾患研究会, Feb. 2018. 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 青山万理子, 行重佐和香, 森本雅美, 武知浩和, 丹黒章 :
CTリンパ管造影を用いた表在型食道癌におけるリンパ節転移診断と治療成績,
第38回四国食道疾患研究会, 2018年2月. 髙杉遥, 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 松本大資, 乾友浩, 都築英雄, 丹黒章 :
A case of advanced colon cancer arising from a colon graft for an esophago-bronchial fistula,
第38回四国食道疾患研究会, 2018年2月. 井上聖也, 吉田卓弘, 西野豪志, 後藤正和, 青山万理子, 行重佐和香, 森本雅美, 武知浩和, 丹黒章 :
食道癌におけるEGFR, HER-2発現の意義,
第38回四国食道疾患研究会, 2018年2月. 吉田光輝, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
組織診断に苦慮した前縦隔腫瘍の1切除例,
第37回日本胸腺研究会, 2018年2月. 西野豪志, 吉田卓弘, 井上聖也, 後藤正和, 武知浩和, 清家純一, 丹黒章 :
縦隔鏡下食道癌根治術を目指した縦隔鏡・胸腔鏡ハイブリッド手術,
第32回四国内視鏡外科研究会, 2018年2月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対してICG蛍光観察下に胸腔鏡下肺部分切除術を行った1例,
第32回四国内視鏡外科研究会, 2018年2月. Hirokazu Takechi, 行重佐和香, 池内真由美, 森本雅美, Misako Nakagawa, Kazumasa Okumura, Hiroaki Toba, Takahiro Yoshida and Akira Tangoku :
高齢男性に発症した乳腺筋線維芽細胞腫の1例,
第24回日本乳腺疾患研究会, Feb. 2018. 池内真由美, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章 :
乳癌術後補助化学療法中に白質脳症をきたした1例,
2017年度徳島外科医会, 2018年2月. 行重佐和香, 吉田卓弘, 西野豪志, 後藤正和, 井上聖也, 丹黒章, 上原久典, 米田亜樹子 :
食道アカラシアに合併した食道扁平上皮癌に対する食道亜全摘術の1例,
2017年度徳島外科医会, 2018年2月. 武知浩和, 松岡由江, 一宮由貴, 三木幸代, 森本雅美, 中川美砂子, 奥村和正, 鳥羽博明, 吉田卓弘, 丹黒章 :
こんな医療がしたかったと認識できた乳癌の1例,
第79回徳島乳腺研究会, 2017年10月. 丹黒章 :
一病息災,
徳島ピンクリボン集会2017, 2017年8月. 丹黒章 :
乳がんの最新治療と診療連携,
中国・四国高度がんプロ養成基盤プログラム第11回地域医療セミナー, 2017年3月. 青山万理子, 坪井光弘, 滝沢宏光, 丹黒章 :
橋本病によるステロイド抵抗性有痛性甲状腺炎の1例,
第45回中国四国甲状腺外科研究会, 2017年2月. 坪井光弘, 青山万理子, 滝沢宏光, 西岡康平, 藤本啓介, 宮本直輝, 河北直也, 丹黒章 :
レンバチニブ投与後に甲状腺全摘・気管合併切除を行った局所進行甲状腺乳頭癌の1例,
第45回中国四国甲状腺外科研究会, 2017年2月. 森本雅美, 武知浩和, 中川美砂子, 鳥羽博明, 丹黒章 :
乳房再建術で手術部位感染を発症し大腿部皮膚からの分層植皮を余儀なくされた1例,
第25回徳島外科術後管理研究会, 2017年2月. 山本清成, 西野豪志, 吉田卓弘, 井上聖也, 澤田徹, 宮本直輝, 西岡康平, 藤本啓介, 青山万理子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
食道癌術後の遅発性難治性乳糜胸に対してリピオドールリンパ管造影が有効であった1例,
第25回徳島外科術後管理研究会, 2017年2月. Wusiman Nuliamina, 近藤和也, 梶浦耕一郎, 坪井光弘, 岸渕麗奈, 鳥羽博明, 河北直也, 澤田徹, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるGAD1(glutamic acid decarboxylase 1)遺伝子プロモーター領域のDNAメチル化,
第36回日本胸腺研究会, 2017年2月. 井上聖也, 吉田卓弘, 西野豪志, 宮本直輝, 西岡康平, 藤本啓介, 青山万理子, 澤田徹, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
当教室における食道切除術の工夫と成績,
第37回四国食道疾患研究会, 2017年1月. 藤本啓介, 吉田卓弘, 西野豪志, 井上聖也, 宮本直輝, 西岡康平, 青山万理子, 澤田徹, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
食道炎による食道閉鎖を50年間耐え抜いた患者に対して食道切除再建を施行した1例,
第37回四国食道疾患研究会, 2017年1月. 西野豪志, 吉田卓弘, 井上聖也, 宮本直輝, 西岡康平, 藤本啓介, 青山万理子, 澤田徹, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
食道癌気管気管支浸潤の診断における超音波気管支鏡検査の有用性,
第37回四国食道疾患研究会, 2017年1月. 西岡康平, 吉田卓弘, 西野豪志, 井上聖也, 宮本直輝, 藤本啓介, 青山万理子, 澤田徹, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
進行食道癌と診断された食道粘膜下血腫の1例,
第37回四国食道疾患研究会, 2017年1月. 丹黒章 :
癌を知りがんを克服する∼乳がんの最新治療∼,
阿南共栄病院・阿南中央病院・阿南市医師会合同市民公開講座乳がんの最新情報と新病院外科系診療科の特徴, 2016年11月. 丹黒章 :
若年性乳がんについて知りましょう,
若年性乳がん患者コミュニティSister, 2016年10月. 丹黒章 :
《特別講演》がんを知りがんを克服する-乳がんの予防と最新治療-,
四国こどもとおとなの医療センター市民公開講座男性の病気，女性の病気, 2016年9月. 西脇裕記, 石本卓也, 芥川正武, 榎本崇宏, 安野恵実子, 丹黒章, 小中信典, 木内陽介 :
電極位置切り替え機能を実装した生体インピーダンス測定装置の検討,
電子情報通信学会技術研究報告(MEとバイオサイバネティックス), Vol.116, No.170, 37-40, 2016年7月.

(要約): 乳がん検診で乳がんの疑いありと診断され，その診断を確定するときに針生検で腫瘍の組織を直接採取する必要がある．腫瘍が小さい場合は，組織を採取できる大きさになるまで経過観察が余儀なくされる．そのような小さな腫瘍に対して，生検を行う前に生体インピーダンスを用いた非侵襲的な診断を行うことで，患者への精神的負担を軽減することが本研究の目標であり，診断する測定装置を独自で開発している．腫瘍の直上から健常な乳腺組織まで測定位置を変えながら測定していくことを乳腺腫瘍の判別方法として提案した．計算機シミュレーションの結果，有効である可能性が示唆された．本研究では，測定位置の変更をリレーを用いた切り替え回路を測定装置に組み込むことにより実現した．作製した装置を用いてジャガイモファントムを測定し，機能評価をしたところ，提案した診断方法へ活用可能であることを確認した．
(キーワード): 生体インピーダンス / 計測装置 (measurement devices) / リレー / 乳がん (breast carcinoma) / ジャガイモ
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1520009408873304960

(CiNii: 1520009408873304960) 松下洋輔, 小松正人, 清谷一馬, 吉丸哲郎, 宮川義仁, 本田純子, 井本逸勢, 丹黒章, 三好康雄, 笹三徳, 片桐豊雅 :
次世代シーケンス解析によるトリプルネガティブ乳癌の分子特性の解明,
第75回徳島乳腺研究会, 2016年4月. 山田亮, 髙杉遥, 吉田卓弘, 乾友浩, 松本大資, 井上聖也, 西野豪志, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
食道切除後の再建結腸に発生した進行結腸癌の1切除例,
第252回徳島医学会学術集会, 2016年2月. 乾友浩, 松本大資, 髙杉遥, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 先山正二, 丹黒章 :
術後乳糜胸により診断し得た縦隔内胸管嚢胞の1例,
第24回徳島外科術後管理研究会, 2016年2月. 髙杉遥, 吉田卓弘, 西野豪志, 井上聖也, 乾友浩, 松本大資, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章 :
食道癌術後の胃管壊死の1例,
第24回徳島外科術後管理研究会, 2016年2月. 藤本啓介, 井上聖也, 吉田卓弘, 古北由仁, 髙杉遥, 乾友浩, 松本大資, 西野豪志, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章, 安倍吉郎, 山崎裕行, 佐々木健介, 柏木圭介, 橋本一郎 :
二度の再建臓器の壊死にて治療に難渋した食道癌の1例,
第24回徳島外科術後管理研究会, 2016年2月. 坪井光弘, 滝沢宏光, 乾友浩, 髙杉遥, 松本大資, 河北直也, 丹黒章 :
総頸頚動脈再建を行った甲状腺乳頭癌の1例,
第44回中国四国甲状腺外科研究会, 2016年1月. 滝沢宏光, 坪井光弘, 武知浩和, 丹黒章 :
多発リンパ節転移を伴った甲状腺髄様癌の1切除例,
第44回中国四国甲状腺外科研究会, 2016年1月. 髙杉遥, 吉田卓弘, 西野豪志, 井上聖也, 髙杉遥, 松本大資, 藤本啓介, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
胸骨後経路食道再建結腸に発生した進行結腸癌に対する1切除例,
第36回四国食道疾患研究会, 2016年1月. 井上聖也, 吉田卓弘, 西野豪志, 乾友浩, 髙杉遥, 松本大資, 藤本啓介, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
胸部食道癌の化学放射線療法後局所遺残再発に対するタラポルフィンナトリウムを用いた光線力学治療の1例,
第36回四国食道疾患研究会, 2016年1月. 西野豪志, 吉田卓弘, 井上聖也, 乾友浩, 髙杉遥, 松本大資, 藤本啓介, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 清家純一, 丹黒章 :
食道癌治療における口腔機能管理の意義,
第36回四国食道疾患研究会, 2016年1月. 吉田卓弘, 西野豪志, 井上聖也, 藤本啓介, 髙杉遥, 乾友浩, 松本大資, 森本雅美, 中川美砂子, 奥村和正, 武知浩和, 丹黒章 :
食道良性疾患における食道運動機能評価の有用性,
第36回四国食道疾患研究会, 2016年1月. 松岡由江, 一宮由貴, 小川美佳, 三木幸代, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
乳がん患者に対するアピアランス支援∼徳島大学病院乳腺外科での取り組み∼,
第73回徳島乳腺研究会, 2015年10月. 丹黒章 :
乳がんの最新治療∼チーム医療と病診連携の重要性∼,
第107回県民公開学術研修セミナー講演会, 2015年9月. 行重佐和香, 鳥羽博明, 川上行奎, 近藤和也, 河北直也, 坪井光弘, 梶浦耕一郎, 滝沢宏光, 先山正二, 丹黒章 :
肺犬糸状虫症の1切除例,
第251回徳島医学会学術集会, 2015年8月. 丹黒章, 田所由紀子, 武知浩和, 鳥羽博明, 中川美砂子, 森本雅美, 橋本一郎, 安倍吉郎, 井本逸勢 :
《公開シンポジウム》遺伝性乳がんについて,
第251回徳島医学会学術集会, 2015年8月. 丹黒章 :
食道がんの診断と治療,
中国・四国高度がんプロ養成基盤プログラムがん栄養セミナー, 2015年8月. 丹黒章 :
乳がんの最新治療と県下統一パスによる病診連携,
第21回徳島大学病院がん診療連携セミナー, 2015年7月. 松本大資, 乾友浩, 髙杉遥, 井上聖也, 西野豪志, 武知浩和, 吉田卓弘, 丹黒章 :
食道裂孔ヘルニアの治療経験,
第12回中国四国ヘルニア手術研究会, 2015年7月. 丹黒章 :
《特別講演》乳癌治療における最新画像診断とチーム医療,
埼玉西部乳癌薬物療法セミナー, 2015年6月. 丹黒章 :
縦隔鏡を用いた食道手術,
東海大学食道手術手技セミナー, 2015年6月. 丹黒章 :
《教育講演》食道癌の集学的治療,
第52回千葉消化器疾患研究会, 2015年6月. 兼松美幸, 坂東良美, 笹三徳, 高橋雅子, 本田純子, 森本雅美, 中川美砂子, 田所由紀子, 吉田卓弘, 井本逸勢, 森谷卓也, 梶川愛一郎, 丹黒章 :
Ki67を指標とした低悪性度DCISの同定とその画像所見,
第72回徳島乳腺研究会, 2015年4月. 森本雅美, 坂東良美, 本田純子, 中川美砂子, 武知浩和, 田所由紀子, 笹三徳, 丹黒章 :
乳癌組織の細胞診検体での免疫染色が組織診検体の免疫染色に代替可能であるか否かの検討,
第72回徳島乳腺研究会, 2015年4月. 丹黒章 :
縦隔鏡下食道切除術,
第27回高知手術手技研究会, 2015年3月. 丹黒章 :
がんの予防とは-乳がんを例に-,
「中国・四国広域がんプロ養成コンソーシアム・徳島大学大学院市民公開講座」がんを知りがんを克服する, 2015年3月. 丹黒章 :
がんの予防とはー乳がんを例にー,
中国・四国広域がんプロ養成コンソーシアム・徳島大学大学院市民公開講座, 2015年3月. 梶浦耕一郎, 先山正二, 近藤和也, 坂本晋一, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 丹黒章 :
Autofluorescence imaging(AFI)にて陰性所見を呈した中枢型早期扁平上皮癌の1症例,
第23回日本呼吸器内視鏡学会中国四国支部会, 2015年2月. 住友弘幸, 西野豪志, 坪井光弘, 坂本晋一, 古北由仁, 吉田卓弘, 武知浩和, 丹黒章 :
発症後3ヶ月目の食道ステント留置が奏功した特発性食道破裂の一例,
第23回徳島外科術後管理研究会, 2015年2月. 中原佳子, 田所由紀子, 一宮由貴, 谷奈積, 川口博美, 松岡由江, 森本雅美, 中川美砂子, 武知浩和, 中野渡友香, 長尾芳美, 佐藤紀, 江西哲也, 柴山純子, 森玲子, 加藤真介, 丹黒章 :
リンパ浮腫予防指導を含めた当院での乳がん周術期患者への関わり∼多職種連携を通じて∼,
第21回日本乳腺疾患研究会, 2015年2月. 坪井光弘, 中川靖士, 滝沢宏光, 坂本晋一, 住友弘幸, 丹黒章 :
当科における甲状腺乳頭癌リンパ節転移の検討,
第43回中国四国甲状腺外科研究会, 2015年2月. 中川靖士, 坂本晋一, 住友弘幸, 坪井光弘, 滝沢宏光, 丹黒章 :
甲状腺手術後出血症例の検討,
第43回中国四国甲状腺外科研究会, 2015年2月. 梶浦耕一郎, 近藤和也, 森本友樹, 坪井光弘, 中川靖士, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺嚢胞と鑑別を要する腫瘍の大部分が嚢胞性変化を起こした胸腺腫の検討,
第34回日本胸腺研究会, 2015年2月. 梶浦耕一郎, 近藤和也, 森本友樹, 坪井光弘, 中川靖士, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺癌におけるRASSF1遺伝子のDNAメチル化はB3胸腺腫よりも高い,
第34回日本胸腺研究会, 2015年2月. 乾友浩, 田所由紀子, 森本雅美, 中川美砂子, 武知浩和, 丹黒章 :
急速に増大した乳腺葉状腫瘍の3例,
第250回徳島医学会学術集会, 2015年2月. 古北由仁, 吉田卓弘, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
食道癌における予後予測因子としてのsystemic inflammatory response,
第35回四国食道疾患研究会, 2015年1月. 吉田卓弘, 古北由仁, 西野豪志, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
食道切除術における予防的ランジオロールの臨床試験結果と今後の展望,
第35回四国食道疾患研究会, 2015年1月. 住友弘幸, 西野豪志, 古北由仁, 坂本晋一, 吉田卓弘, 武知浩和, 清家純一, 滝沢宏光, 丹黒章 :
バセドウ病に合併し，甲状腺亜全摘と食道憩室切除を同時に行ったkillian-Jamieson憩室症の1例,
第35回四国食道疾患研究会, 2015年1月. 西野豪志, 古北由仁, 吉田卓弘, 坂本晋一, 住友弘幸, 武知浩和, 清家純一, 丹黒章 :
気管・気管支浸潤を伴う進行食道癌の治療戦略―正確な浸潤診断のために-,
第35回四国食道疾患研究会, 2015年1月. 一宮由貴, 鈴木察子, 木田菊恵, 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
看護師の補足説明による乳がん患者・家族の意思決定支援∼当院の役割拡大実践能力育成プログラムに参加して,
第10回四国地区Breast Cancer研究会, 2014年10月. 今井芳枝, 中川美砂子, 滝本理沙, 近藤和也, 坂東孝枝, 雄西智惠美, 笹三徳, 田所由紀子, 丹黒章, 森恵子, 友竹正人, 髙尾正一郎, 上野淳二, 高橋雅子, 廣瀬千恵子, 久岡園花 :
ホルモン受容体陽性閉経後乳癌に対するアロマターゼ阻害(AI)剤投与前後の症状とQOLの変化,
第69回徳島乳腺研究会, 2014年4月. 一宮由貴, 鈴木察子, 三木幸代, 中川美砂子, 田所由紀子, 丹黒章 :
看護師の補足説明によるがん患者・家族の意思決定支援,
第69回徳島乳腺研究会, 2014年4月. 森下敦司, 吉田卓弘, 西野豪志, 古北由仁, 武知浩和, 丹黒章 :
食道大動脈瘻を呈した食道癌に対しTEVARで救命し得た1例,
第22回徳島外科術後管理研究会, 2014年3月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 坪井光弘, 中川美砂子, 西野豪志, 梶浦耕一郎, 武知浩和, 吉田卓弘, 清家純一 :
食道切除・再建術におけるE-PASSスコアと舌骨下筋群切離の有用性,
第22回徳島外科術後管理研究会, 2014年3月. 吉田卓弘, 古北由仁, 西野豪志, 森下敦司, 武知浩和, 丹黒章 :
ロボット支援下Heller-Dor手術,
第28回四国内視鏡外科研究会, 2014年2月. 坪井光弘, 森下敦司, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
当院におけるPowered ECHELON FLEXTMの使用経験,
第28回四国内視鏡外科研究会, 2014年2月. 森下敦司, 近藤和也, 松井尚子, 坂東良美, 梶浦耕一郎, 滝沢宏光, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
重症筋無力症を伴った胸腺のmultiple microcystsの一例,
第33回日本胸腺研究会, 2014年2月. 中川靖士, 近藤和也, Mokhtar Mohamed, Ali Abdellah, 名村寿章, 梶浦耕一郎, 森本友樹, 高井チカ子, 滝沢宏光, 鳥羽博明, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
第33回日本胸腺研究会,
胸腺上皮性腫瘍におけるDNA修復遺伝子MGMTのメチル化と発現低下, 2014年2月. 森下敦司, 古北由仁, 森本雅美, 坪井光弘, 西野豪志, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
放射線治療が再発巣コントロールに有効であった食道原発悪性黒色腫の一例,
第34回四国食道疾患研究会, 2014年2月. 古北由仁, 丹黒章, 森下敦司, 森本雅美, 西野豪志, 武知浩和, 吉田卓弘, 清家純一 :
食道癌における腫瘍内リンパ球浸潤は化学療法の治療効果を予見する?,
第34回四国食道疾患研究会, 2014年2月. 西野豪志, 吉田卓弘, 森下敦司, 山本洋太, 古北由仁, 武知浩和, 丹黒章 :
食道癌周術期における大建中湯の有用性についての検討,
第34回四国食道疾患研究会, 2014年2月. 吉田卓弘, 丹黒章, 古北由仁, 西野豪志, 森下敦司, 武知浩和 :
当科における胸腔鏡補助下食道切除術,
第34回四国食道疾患研究会, 2014年2月. 高橋彩加, 古北由仁, 吉田卓弘, 西野豪志, 森下敦司, 森本雅美, 武知浩和, 清家純一, 丹黒章, 中山泰介, 木下肇, 藤本鋭貴 :
食道癌放射線治療後の食道大動脈瘻に対し大動脈ステントグラフト内挿術で救命しえた1例,
第34回四国食道疾患研究会, 2014年2月. 丹黒章 :
食道がんの個別化治療を目指して,
第6回関東食道外科若手の会講演会, 2014年1月. Akira Tangoku :
Lecture1Esophageal CancerSurgical Treatment and Nutritional Care,
International Symposium on Oncology Nutrition in Tokushima, Jan. 2014. 森本雅美, 中川美砂子, 武知浩和, 田所由紀子, 丹黒章 :
S-1+nab PTXにより効果が得られた多剤抵抗性再発乳癌の2例,
第67回徳島乳腺研究会, 2013年10月. 丹黒章 :
乳癌の地域連携,
第17回徳島大学病院がん診療連携セミナー, 2013年7月. 古北由仁, 丹黒章, 坂本晋一, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
好中球リンパ球比は食道癌化学療法の効果予測因子となりうる,
第34回癌免疫外科研究会, 2013年5月. 滝沢宏光, 池田真由美, 古川尊子, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
ICG蛍光内視鏡を用いた胸腔鏡下区域切除域,
第11回スプリングセミナー IN OKINAWA, 2013年3月. 西野豪志, 先山正二, 池田真由美, 森本雅美, 古川尊子, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 中川靖士, 近藤和也, 丹黒章 :
胸腔鏡手術を施行した月経随伴性気胸の2例,
第27回四国内視鏡外科研究会, 2013年2月. 田所由紀子, 中川美砂子, 池田真由美, 古川尊子, 森本雅美, 武知浩和, 丹黒章 :
Adenomyoepitheliomaの2例,
第19回日本乳腺疾患研究会, 2013年2月. 高井ちか子, 中川靖士, 大岩由香理, 藤田結衣, 滝沢宏光, 吉田光輝, 川上行奎, 梶浦耕一郎, 先山正二, 丹黒章, 高浜洋介, 近藤和也 :
ヒト胸腺・胸腺腫における皮質・髄質componentのdistribution,
第32回日本胸腺研究会, 2013年2月. 吉田光輝, 近藤和也, 横石道寛, 中川靖士, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
症筋無力症患者の術前3D画像解析が拡大胸腺摘出術後の予後予測に及ぼす可能性,
第32回日本胸腺研究会, 2013年2月. 池田真由美, 西野豪志, 先山正二, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫術後に両側横隔神経麻痺による呼吸不全をきたした1例,
第21回徳島外科術後管理研究会, 2013年2月. 森本雅美, 田所由紀子, 池田真由美, 古川尊子, 中川美砂子, 丹黒章 :
乳房再建術後感染でティッシュエキスパンダーの摘出を余儀なくされた1例,
第21回徳島外科術後管理研究会, 2013年2月. 古川尊子, 中川美砂子, 田所由紀子, 池田真由美, 森本雅美, 武知浩和, 中川靖士, 丹黒章 :
サブタイプ別再発形式から考えた乳癌術後フォローアップの検討,
第21回徳島外科術後管理研究会, 2013年2月. 坂本晋一, 古北由仁, 丹黒章, 宮本佳美, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
初期治療が奏効するも不良な転帰を辿った食道内分泌細胞癌の2例,
第33回四国食道疾患研究会, 2013年2月. 西野豪志, 山本洋太, 池田真由美, 古川尊子, 後藤正和, 古北由仁, 湯浅康弘, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道扁平上皮癌に対する術前DFP療法(weeklyDOC+low-doseFP)の有用性,
第33回四国食道疾患研究会, 2013年2月. 山本洋太, 坂本晋一, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 古北由仁, 湯浅康弘, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道亜全摘術後の長期的体重変化の検討,
第33回四国食道疾患研究会, 2013年2月. 古北由仁, 丹黒章, 坂本晋一, 宮本佳美, 池田真由美, 古川尊子, 森本雅美, 後藤正和, 西野豪志, 山本洋太, 武知浩和, 清家純一 :
食道癌手術のリスク評価におけるE-PASSの有用性,
第33回四国食道疾患研究会, 2013年2月. 後藤正和, 坂本晋一, 池田真由美, 古川尊子, 西野豪志, 湊拓也, 梶浦耕一郎, 古北由仁, 山本洋太, 湯浅康弘, 武知浩和, 吉田卓弘, 清家純一, 丹黒章 :
食道癌術後吻合部狭窄症例の検討,
第33回四国食道疾患研究会, 2013年2月. 岩見誠治, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵実子, 猪子拓人, 高橋知也 :
浅部腫瘍生体組織インピーダンス測定のための電極配置について,
電子情報通信学会技術研究報告, Vol.112, No.123, 25-29, 2012年7月.

(要約): 過去の研究によって，生体組織の電気抵抗が正常組織と悪性腫瘍とで違いがあることがわかっている．これまで開発してきた装置は測定電極を固定しているものだった．本研究では生体等価回路モデルを利用しシミュレーションを行い電極配置の違いによっての測定への影響について調ベることである．生体等価回路を用いてシミュレーションを行った結果，浅部腫瘍生体組織インピーダンス測定において有効と思われる電極配置を提示した．
(キーワード): シミュレーション (simulation) / 電極配置 / 生体等価回路モデル

山本洋太, 井上聖也, 後藤正和, 湊拓也, 古北由仁, 湯浅康弘, 武知浩和, 清家純一, 安倍吉郎, 橋本一郎, 丹黒章 :
食道胃管吻合部の再建術後に生じた難治性消化管皮膚瘻に対し，腸頚靱帯筋膜パッチ，有茎大胸筋弁充填術で治癒せしめた一例,
第20回徳島外科術後管理研究会, 2012年2月. 森本雅美, 後藤正和, 湊拓也, 古北由仁, 山本洋太, 武知浩和, 松岡永, 清家純一, 三好孝典, 丹黒章 :
気管穿通を伴う局所進行食道癌に対して集学的治療が奏功した一例,
第20回徳島外科術後管理研究会, 2012年2月. 宮本佳美, 中川靖士, 滝沢宏光, 森本雅美, 後藤正和, 中川美砂子, 梶浦耕一郎, 古北由仁, 山本洋太, 武知浩和, 川上行奎, 吉田光輝, 監﨑孝一郎, 丹黒章 :
当科における頚部手術後出欠症例の検討,
第20回徳島外科術後管理研究会, 2012年2月. 古北由仁, 丹黒章, 森本雅美, 後藤正和, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一 :
食道癌治療におけるGlasgow prognostic scoreを用いたリスク評価,
第32回四国食道疾患研究会, 2012年2月. 後藤正和, 丹黒章, 山本洋太, 森本雅美, 梶浦耕一郎, 古北由仁, 武知浩和, 清家純一 :
食道癌術後に横隔膜ヘルニアからイレウスに至った1例,
第32回四国食道疾患研究会, 2012年2月. 岩見誠治, 芥川正武, 榎本崇宏, 小中信典, 木内陽介, 森本忠興, 丹黒章, 岡﨑憲二, 安野恵美子, 猪子拓人, 高橋知也 :
浅部腫瘍生体組織インピーダンス測定のための電極配置について,
電子情報通信学会技術研究報告(MEとバイオサイバネティックス), Vol.112, No.123, 25-29, 2012年.

(キーワード): 異物(診断)

森本雅美, 中川美砂子, 武知浩和, 川上行奎, 吉田光輝, 丹黒章 :
Mohs軟膏が有用であった局所進行乳癌の2例,
第61回徳島乳腺研究会, 2011年10月. 古北由仁, 森本雅美, 後藤正和, 湊拓也, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
Nissen術後の通過障害に対し再手術を施行した1例,
第86回中国四国外科学会総会, 2011年9月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肝細胞癌術後肺転移に対するICG蛍光法による腫瘍検出の試み,
第16回中国四国内視鏡外科研究会, 2011年9月. 丹黒章 :
癌化学療法とサポーティブケア,
鳴門病院地域連携学術講演会, 2011年8月. 丹黒章 :
ビデオカンファレンス形式,
第1回せとうちMIS勉強会, 2011年7月. 梶浦耕一郎, 滝沢宏光, 高嶋美佳, 宇山攻, 鳥羽博明, 川上行奎, 中川靖士, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
多彩な陰影を呈した結節性リンパ組織過形成の3切除例,
第46回日本呼吸器学会中国・四国地方会第50回日本肺癌学会中国・四国支部会, 2011年7月. 丹黒章, 古北由仁, 山本洋太, 湊拓也, 後藤正和 :
食道癌に対する新たな治療戦略,
第54回関西胸部外科学会学術集会, 2011年6月. 丹黒章 :
がんの低侵襲治療,
第50回徳島臨床カンファランス, 2011年6月. 中川美砂子, 青山万理子, 池田真由美, 森本雅美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
進行乳癌に対するS-1+Docetaxelを用いた術前補助化学療法,
乳がん化学療法学術講演会, 2011年6月. 今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 板東孝枝, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する実態調査,
第60回徳島乳腺研究会, 2011年4月. 青山万理子, 中川靖士, 滝沢宏光, 丹黒章 :
甲状腺乳頭癌転移巣からBasedow病を来した1例,
第39回中国四国甲状腺外科研究会, 2011年3月. 丹黒章 :
乳癌の低浸襲治療の実現をめざして,
第17回日本乳腺疾患研究会, 2011年2月. 兼松美幸, 滝沢宏光, 近藤和也, 池田真由美, 三崎万理子, 高嶋美佳, 湊拓也, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川美砂子, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
肺癌術後に肺動脈血栓塞栓症ならびにAcinetobacter baumannii敗血症を発症し，治療に難渋した1例,
第19回徳島外科術後管理研究会, 2011年2月. 池田真由美, 中川美砂子, 三崎万理子, 高嶋美佳, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
乳癌に対する腋窩郭清術後に乳び漏を発症した2例,
第19回徳島外科術後管理研究会, 2011年2月. 湊拓也, 池田真由美, 三崎万理子, 高嶋美佳, 古北由仁, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道亜全摘，胃管再建術における縫合不全の検討,
第19回徳島外科術後管理研究会, 2011年2月. 高嶋美佳, 山本洋太, 池田真由美, 三崎万理子, 湊拓也, 古北由仁, 武知浩和, 清家純一, 丹黒章 :
周術期に脳転移による脳ヘルニアを発症した1例,
第19回徳島外科術後管理研究会, 2011年2月. 古北由仁, 三崎万理子, 池田真由美, 高嶋美佳, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
当科における食道良性疾患の腹腔鏡下手術の検討,
第9回せとうち消化管運動研究会, 2011年2月. 名村寿章, 近藤和也, Ali Hamed Khalil Abdellah, 藤田結衣, 岩佐裕介, 仙波義貴, 大岩由香理, 高井チカ子, 中川靖士, 滝沢宏光, 鳥羽博明, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺腫と胸腺癌におけるDNA修復遺伝子MGMT(O_6-methylguanine DNA methyltransferase)のメチル化,
第30回日本胸腺研究会, 2011年2月. 丹黒章 :
食道癌に対する縦隔鏡下食道切除術,
第5回食道・胃外科フォーラム, 2011年1月. 湊拓也, 湯浅康弘, 池田真由美, 三崎万理子, 高嶋美佳, 古北由仁, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
食道亜全摘，胃管再建術における縫合不全の検討,
第31回四国食道疾患研究会, 2011年1月. 高嶋美佳, 山本洋太, 池田真由美, 三崎万理子, 湊拓也, 古北由仁, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
周術期に脳転移による脳ヘルニアを発症した1例,
第31回四国食道疾患研究会, 2011年1月. 古北由仁, 三崎万理子, 池田真由美, 高嶋美佳, 湊拓也, 梶浦耕一郎, 山本洋太, 武知浩和, 清家純一, 丹黒章 :
当科における食道良性疾患の腹腔鏡下手術の検討,
第31回四国食道疾患研究会, 2011年1月. 山本洋太, 池田真由美, 三崎万理子, 高嶋美佳, 湊拓也, 古北由仁, 梶浦耕一郎, 武知浩和, 清家純一, 丹黒章 :
当科における女性食道扁平上皮癌の検討,
第31回四国食道疾患研究会, 2011年1月. 鳥羽博明, 先山正二, 高田香, 高嶋美佳, 梶浦耕一郎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
摘出時にラリンジアルマスクが効果的であった小児気管支異物の1例,
第19回日本呼吸器内視鏡学会中国四国支部会, 2011年1月. 丹黒章 :
外科治療の進歩と今日の麻酔管理について-フロートラックセンサーを用いた循環管理-,
徳島県医師会学術講演会, 2010年12月. 中川美砂子, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
進行性乳癌に対する完遂率を高め，組織学的寛解率向上をめざした術前化学療法多施設共同臨床試験(N-1Trial)中間報告,
第5回徳島乳癌学術講演会, 2010年11月. 高嶋美佳, 中川美砂子, 池田真由美, 武知浩和, 川上行奎, 監﨑孝一郎, 丹黒章 :
当科における高用量トレミフェンの位置づけ,
徳島県HD-TOR研究会, 2010年10月. 丹黒章 :
乳がんについて,
乳がんに関する啓発セミナー及び乳がん検診, 2010年9月. 中川美砂子, 森本雅美, 坂東良美, 丹黒章 :
乳房温存術後の切除断端陽性症例に対する放射線療法後追加切除の検討,
第7回日本乳癌学会中国四国地方会, 2010年9月. 丹黒章 :
乳癌術後連携パスのご紹介,
徳島県がん診療連携セミナー, 2010年9月. 丹黒章 :
がんとうまく付き合いましょう,
徳島ピンクリボン集会2010, 2010年8月. 丹黒章 :
乳がんの最新治療,
第11回徳島大学病院がん診療連携セミナー, 2010年7月. 丹黒章 :
食道がんの最新治療,
第11回徳島大学病院がん診療連携セミナー, 2010年7月. 中川美砂子, 坂東良美, 丹黒章 :
乳房温存術後の切除断端陽性症例に対する術後放射線療法の検討,
第14回四国乳房画像研究会, 2010年7月. 兼松美幸, 監﨑孝一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
迷入性縦隔内甲状腺腫の一例,
第45回日本呼吸器学会中国・四国地方会第49回日本肺癌学会中国・四国支部会, 2010年7月. 監﨑孝一郎, 近藤和也, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸膜肺全摘術を施行した悪性胸膜中皮腫の臨床的検討,
第45回日本呼吸器学会中国・四国地方会第49回日本肺癌学会中国・四国支部会, 2010年7月. 丹黒章, 中川美砂子, 武知浩和, 川上行奎 :
乳癌センチネルリンパ節診断における3D-CT lymphographyの有用性,
第11回乳癌最新情報カンファランス, 2010年7月. 高嶋美佳, 鳥羽博明, 先山正二, 藤原聡史, 兼松美幸, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
縦隔リンパ節転移を有する胸腺異型カルチノイドに対して集学的治療を行った1例,
第53回関西胸部外科学会学術集会, 2010年6月. 古北由仁, 丹黒章, 清家純一, 山本洋太, 藤原聡史, 井上聖也, 森本雅美, 兼松美幸, 高嶋美佳 :
食道表在癌に対するセンチネルリンパ節ナビゲーションと縦隔鏡手術,
第53回関西胸部外科学会学術集会, 2010年6月. 丹黒章 :
食道癌の最新治療,
阿波・吉野川市地域医療勉強会, 2010年6月. 丹黒章 :
乳癌診療最近の話題,
第2回徳島市医師会学術講演会乳がん検診説明会, 2010年6月. 丹黒章 :
乳がんの診療・最近のトピックス,
平成22年度徳島県臨床検査技師会定期総会, 2010年5月. 中川美砂子, 森本雅美, 丹黒章, 笹三徳, 坂東良美 :
Triple negative 乳癌(TNBC)の組織学的特徴-バイオマーカーによる亜分類確立を目指して-,
第57回徳島乳腺研究会, 2010年4月. 丹黒章 :
喉頭，食道切除後の再建臓器に関する基礎的，臨床的研究(特に除神経の影響について),
科学研究費補助金基盤研究(C)(2)研究成果報告書, 平成8年度-平成10年度, 1999年3月. 丹黒章 :
食道癌におけるNM23-H1をターゲットとした化学療法の開発,
科学研究費補助金基盤研究(C)(2)研究成果報告書, 平成8年度-平成10年度, 1999年3月.

(キーワード): 食道癌

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: 腫瘍が分泌するLOXはLuminal型乳癌の骨転移予見バイオマーカーになり得る (研究課題/領域番号: 19K09046 )
乳腺幹細胞を用いた乳汁産生機能を有する乳腺の再生 (研究課題/領域番号: 17K10552 )
生検組織診断による食道癌個別治療の実現 (研究課題/領域番号: 17K10514 )
RNA結合蛋白のアイソフォームに内在する食道癌促進分子スイッチの分子機序の解明 (研究課題/領域番号: 16K15618 )
腫瘍内不均一性のオミックスデータモデリングとゲノム編集に基く食道癌治療法の最適化 (研究課題/領域番号: 26293304 )
タキサン併用術前化学療法の食道癌への効果予測因子と予後規定因子の解明 (研究課題/領域番号: 24591945 )
食道表在癌に対するセンチネルリンパ節ナビゲーションシステムの構築 (研究課題/領域番号: 23591936 )
次世代型統合的ゲノム解析による食道癌の治療効果予測アルゴリズム構築と分子標的探索 (研究課題/領域番号: 23390325 )
食道癌術前後栄養による免疫能の変化と抗腫瘍効果と術後病態への影響 (研究課題/領域番号: 19591546 )
DNAマイクロアレイ作製による食道表在癌のリンパ節転移診断・関連遺伝子の検出 (研究課題/領域番号: 15591409 )
CT/MRイメージガイド乳癌センチネルリンパ節マッピング (研究課題/領域番号: 15591279 )
食道癌におけるNM23-H1をターゲットとした化学療法の開発 (研究課題/領域番号: 11671241 )
喉頭、食道切除後の再建臓器に関する基礎的臨床的研究(特に除神経の影響について) (研究課題/領域番号: 08671446 )
膵切除残膵の再生促進と幽門輪温存術式の改良 (研究課題/領域番号: 06454387 )
膵切除後の残膵の再生促進と幽門輪温存術式の改良 (研究課題/領域番号: 03454322 )
食道癌における癌遺伝子と抗癌効果に関する研究 (研究課題/領域番号: 63570639 )
VIP神経の食道アカラシア病態生理への関与 (研究課題/領域番号: 61480284 )
研究者番号（10197593）による検索

その他: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年12月20日更新

専門分野・研究分野: 医学 (Medicine)
外科学 (Surgery)
所属学会・所属協会: 日本消化器外科学会
日本外科学会
日本乳癌学会
日本胸部外科学会
日本乳癌検診学会
日本食道学会
American Society of Clinical Oncology
The International Society for Diseases of the Esophagus
International Society of Surgery
日本癌治療学会
日本臨床外科医学会
日本内視鏡外科学会
日本外科系連合学会
日本甲状腺外科学会
日本オンコプラステイック学会
日本バイオセラピー学会
日本がん検診・診断学会
高齢消化器病学会
International Society Diseases of the esophagus
委員歴・役員歴: 日本消化器外科学会 (評議員,資格認定委員,NCDデータベース委員 [2011年4月〜2017年3月])
日本外科学会 (評議員,会誌編集委員,専門医認定委員 [2011年4月〜2021年3月])
日本乳癌学会 (評議員,専門医制度委員,資格認定委員長 [2009年4月〜2017年6月])
日本胸部外科学会 (評議員,理事,関西地方会理事,安全対策委員 [2011年10月〜2017年10月])
日本乳癌検診学会 (評議員,理事 [2011年10月〜2018年9月])
日本食道学会 (評議員,理事,専門医制度委員 [2012年6月〜2021年6月])
American Society of Clinical Oncology (active member [2011年1月〜2018年12月])
The International Society for Diseases of the Esophagus (active member [2012年1月〜2017年12月])
International Society of Surgery (active member [2012年1月〜2020年12月])
日本癌治療学会 (評議員,ガイドライン評価委員 [2012年1月〜2016年12月])
日本臨床外科医学会 (評議員 [2011年1月〜2017年12月])
日本内視鏡外科学会 (評議員,技術認定審査委員 [2011年1月〜2017年12月])
日本外科系連合学会 (副会長,評議員,編集委員 [2012年1月〜2017年6月])
日本甲状腺外科学会 (評議員,症例登録委員 [2011年1月〜2020年12月])
日本オンコプラステイック学会 (理事・評議員 [2011年1月〜2017年12月])
日本バイオセラピー学会 (評議員 [2011年1月〜2017年12月])
日本がん検診・診断学会 (評議員 [2011年1月〜2020年12月])
高齢消化器病学会 (理事 [2015年7月〜2021年6月])
日本乳癌学会 (地方創生委員会顧問 [2016年9月〜2018年8月])
日本乳癌学会 (施設認定委員会顧問 [2016年9月〜2018年8月])
日本乳癌学会 (倫理委員会委員 [2016年9月〜2018年8月])
日本乳癌学会 (理事 [2018年7月〜2020年6月])
日本乳癌検診学会 (副理事長 [2018年10月〜2020年9月])
International Society Diseases of the esophagus (理事 [2018年7月〜2020年6月])
受賞: 研究者総覧に該当データはありませんでした。
活動: 徳島県 (徳島県生活習慣病管理指導協議会乳がん部会長 [2011年4月〜2021年3月])
徳島県地域医療総合対策協議会委員会 (委員 [2009年7月〜2020年7月])
徳島県地域総合対策委員会 (医院 [2016年7月〜2020年6月])
徳島市医師会乳がん検診委員会副委員長 ( [2016年6月〜2020年6月])
国立大学医学部長会議 (研究倫理小委員会委員長 [2017年4月〜2019年3月])
AWAサポートセンター (副センター長[2016.4.1∼ 2021.3.31])
徳島市がん検診促進協議会 (会長 [2019年10月〜2021年10月])
医学科長 (2010年4月)
副病院長 (2013年4月〜2015年3月)
医学部長補佐 (2013年4月〜2015年3月)
医学部長 (2017年4月〜2019年3月)

リサーチマップで最新データを確認するＪグローバルで最新データを確認する

2024年12月22日更新

2024年12月21日更新

Ｊグローバル

Jグローバル最終確認日: 2024/12/21 01:24
氏名（漢字）: 丹黒章
氏名（フリガナ）: タンゴクアキラ
氏名（英字）: Tangoku Akira
所属機関: 徳島大学教授

リサーチマップ

researchmap最終確認日: 2024/12/22 01:42
氏名（漢字）: 丹黒章
氏名（フリガナ）: タンゴクアキラ
氏名（英字）: Tangoku Akira
プロフィール: リサーチマップAPIで取得できませんでした。
登録日時: 2002/7/4 00:00
更新日時: 2020/8/28 16:40
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所属ID: 0344020000
所属: 徳島大学
部署: 大学院ヘルスバイオサイエンス研究部病態制御外科分野生体防御腫瘍医学講座
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学位: 医学博士
学位授与機関: 山口大学
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ＫＡＫＥＮで最新データを確認する

2024年12月21日更新

研究者番号: 10197593

所属（現在）: KAKEN APIで取得できませんでした。

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2019/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 教授
2015/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部, 教授
2011/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2013/4/1 : 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授
2013/4/1 : 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授
2011/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2008/4/1 : 徳島大学, 大学院・ヘルスパ材サ仁ンス研究部, 教授
2007/4/1 – 2008/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2003/4/1 – 2004/4/1 : 山口大学, 医学部, 助教授
1997/4/1 – 2001/4/1 : 山口大学, 医学部, 助教授
1996/4/1 : 山口大学, 医学部, 講師
1993/4/1 – 1995/4/1 : 山口大学, 医学部, 助手
1987/4/1 – 1988/4/1 : 山口大学, 医学部, 助手

審査区分/研究分野

研究代表者

生物系 / 医歯薬学 / 外科系臨床医学 / 消化器外科学
医学 / 外科 / 消化器外科学
生物系 / 医歯薬学 / 外科系臨床医学 / 外科学一般

研究代表者以外

生物系 / 医歯薬学 / 外科系臨床医学 / 消化器外科学
医学 / 外科 / 消化器外科学
生物系 / 医歯薬学 / 内科系臨床医学 / 放射線科学
生物系 / 医歯薬学 / 外科系臨床医学 / 外科学一般
小区分55010:外科学一般および小児外科学関連

キーワード

研究代表者

食道癌 / 食道亜全摘術 / 術後栄養 / 経腸栄養 / 中心静脈栄養 / Th1 / Th2バランス / サプリメント / 抗癌剤 / タキサン / 術前化学療法 / 抗癌剤感受性 / 再建胃管 / 内圧 / pHモニター / シンチグラフィー / Bile sensor / 胃食道十二指腸逆流 / 迷走神経切離 / 消化管ホルモン / 消化管シンチグラフィー / 遊離空腸 / gastric tube / manometry / pH monitoring / scintigraphy / reflu esophagitis / vagotomy / 化学療法 / 制癌剤 / 感受性 / NM23-H1遺伝子 / 転移抑制遺伝子 / 制癌剤感受性 / nm23-H1 / CDDP / Esophageal cancer / chemotherapy / chemosensitivity / cisplatin / prognosis / 治療効果予測 / 予後予測 / Tissue Array

研究代表者以外

食道癌 / ゲノム / エピゲノム / 遺伝子 / トランスレーショナルリサーチ / 次世代シーケンサー / 表在癌 / リンパ節転移 / センチネルリンパ節 / バイオイメージング / オミックス / 分子プロファイリング / ゲノム編集 / シミュレーション / 食道扁平上皮癌 / 癌 / 腫瘍内不均一性 / 膵頭十二指腸切除 / 胃膵相関 / 膵広範切除 / 膵再生 / 膵機能 / 胃切除 / 消化管ホルモン / 栄養 / 膵外分泌機能 / インスリン分泌 / 消化管ホルモン分泌 / 酸分必 / 酸分泌 / Pancratoduodenectomy / Gastropancreatic interaction / Major pancreatectomy / Pancreattic regeneration / Pancreatic function / Gastrectomy / Gut hormones / Nutrition / 膵切除 / プロテアーゼインヒビター / 胃内容排出 / 膵癌 / 迷走神経幽門枝 / 腸間膜根部郭清 / 幽門輪温存術式 / 膵退縮 / 膵栄養効果 / 膵機能不全 / 膵DNA量 / 膵重量 / 神経叢浸潤 / 郭清 / 消化吸収障害 / 上腸間膜動脈 / Pancreatectomy / Protease inhibitor / Pancreatic regeneration / Gastric emptying / Pancreatic cancer / Neural and nodal dissection / Superior mesenteric artery / Pylorus preserving pancreatoduodenectomy / 乳癌 / CT / リンパグラフィ / リンパ節生検 / 造影剤 / MR / Computed tomography (CT) / Breast cancer / Sentinel lymph node / Contrast material / Magnetic resonance imaging (MRI) / CGH / マイクロアレイ / esophageal cancer / microarray / lymphnodes metastasis / 食道アカラシア / LES / Vasoactive Intestinal Polypeptide VIP / substance P / 噴門括約機構 / 下部食道括約筋 / VIP / セクレチン / Substance P / PAP法 / 培養細胞株 / 無血清培養 / EGFrecepter / 癌遺伝子 / 抗癌剤感受性 / Southern blotting / Northern blotting / 食堂癌 / EGF recepter / ヌ-ドマウス / 樹立 / erbB / VPー16 / ヌ-ドマウス皮下移植腫瘍 / in vitro培養系 / Southern blot hybrydazation / 増殖因子 / 増殖因子レセプタ- / 核酸分析 / 腫瘍マーカー / 免疫組織化学 / ヌードマウス移植系 / 培養細胞 / Esophageal cancer / cell line / erb-B / myc / EGF / serum-free culture / Etoposide / 乳房再建 / 乳腺幹細胞 / 乳汁分泌 / RNA結合蛋白 / TIA1 / アイソフォーム / 天然変性領域 / 蛋白リン酸化 / 癌促進作用 / 細胞内局在 / 分子スイッチ / RNA結合タンパク / TIA1a / Luminal型乳癌 / 骨転移 / Lysyl oxidase(LOX) / LOX阻害薬

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