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近藤和也

徳島大学

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Jグローバル
KAKEN
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2024年11月14日更新

職名: 名誉教授 (2024.4)
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学歴: 1992/3: 徳島大学大学院医学研究科博士課程修了
学位: 博士(医学) (徳島大学) (1992年3月)
職歴・経歴: 〜: 徳島大学講師, 大学院ヘルスバイオサイエンス研究部 (-2006.5.)
2006/6: 徳島大学講師, 病院 (-2007.3.)
2007/4: 徳島大学教授, 医学部 (-2008.3.)
2008/4: 徳島大学教授, 大学院ヘルスバイオサイエンス研究部 (-2015.3.)
2015/4: 徳島大学教授, 大学院医歯薬学研究部 (-2024.3.)

専門分野・研究分野: 医学 (Medicine)
呼吸器外科 (Chest Surgery)

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2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
呼吸器外科 (Chest Surgery)
担当経験のある授業科目: 研究者総覧に該当データはありませんでした。
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2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
呼吸器外科 (Chest Surgery)

研究テーマ: 1) クロム酸塩の暴露した肺癌の発癌の分子生物学的解明に関する研究, 胸腺腫及び胸腺癌の悪性度及びその治療に関する研究, 肺癌のリンパ節転移とその治療に関する研究, 胸部の悪性腫瘍―肺癌
乳癌
食道癌の治療(手術・放射線治療・化学療法)後のQOL(quality of life)の調査とその改善する方法の研究 (クロム酸塩発癌, 肺癌, p53癌抑制遺伝子, DNA ミスマッチ修復遺伝子, DNAメチル化, 胸腺腫, 胸腺癌, リンパ節転移) (Our previous molecular studies revealed that a few p53 mutations and no ras mutations were observed in lung cancers from chromate workers (chromate lung cancer), and that p53 mutations found in chromate lung cancers included base substitutions at A/T pairs, which was different from those of smoking-induced lung cancer. We also demonstrated that chromate lung cancer frequently had the microsatellite instability (MSI), and that the MSI was associated with the loss of expression of MLH1, which is one of the essential DNA mismatch repair (MMR) proteins. Methylation in chromate lung cancers was detected at 86% for APC, 20% for MGMT, 28% for hMLH1 and 33% for p16 genes. Whereas, it occurred at lower frequencies in nonchromate lung cancers, particularly in APC (44%) and hMLH1 (0%) genes. chromate lung cancer is linked to the progressive methylation of some tumor suppressor genes, which may be related to genomic instability.)

著書

N Wauthoz, G Bastiat, E Moysan, A Cieślak, Kazuya Kondo, M Zandecki, V Moal, MC Rousselet, J Hureaux and JP Benoit :
Safe lipid nanocapsule-based gel technology to target lymph nodes and combat mediastinal metastases from an orthotopic non-small-cell lung cancer model in SCID-CB17 mice,
Mar. 2015.

(要約): The purpose of this study is the assessment of gel technology based on a lauroyl derivative of gemcitabine encapsulated in lipid nanocapsules delivered subcutaneously or intravenously after dilution to (i) target lymph nodes, (ii) induce less systemic toxicity and (iii) combat mediastinal metastases from an orthotopic model of human, squamous, non-small-cell lung cancer Ma44-3 cells implanted in severe combined immunodeficiency mice. The gel technology mainly targeted lymph nodes as revealed by the biodistribution study. Moreover, the gel technology induced no significant myelosuppression (platelet count) in comparison with the control saline group, unlike the conventional intravenous gemcitabine hydrochloride treated group (P<0.05). Besides, the gel technology, delivered subcutaneously twice a week, was able to combat locally mediastinal metastases from the orthotopic lung tumor and to significantly delay death (P<0.05) as was the diluted gel technology delivered intravenously three times a week. Lung cancer is one of the leading causes of mortality worldwide. A significant proportion of patients with this disease have lymph node metastasis. In this study, the authors investigated the use of lipid nanocapsules, loaded with the lipophilic pro-drug gemcitabine for targeting tumors in lymph nodes after subcutaneous injection. This delivery method was shown to be effective in controlling tumor progression and may be useful in future clinical use.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.nano.2015.02.010
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25791812; ● Summary page in Scopus @ Elsevier: 2-s2.0-84927928449

(DOI: 10.1016/j.nano.2015.02.010, PubMed: 25791812, Elsevier: Scopus) T Mizuno, M Okumura, H Asamura, K Yoshida, H Niwa, Kazuya Kondo, H Horio, A Matsumura and K Yokoi :
Surgical management of recurrent thymic epithelial tumors: a retrospective analysis based on the Japanese nationwide database.,
Jan. 2015.

(要約): There is no standard treatment for recurrent thymic epithelial tumors. Although the efficacy has not been validated based on the large series studies, surgical resection is sometimes employed for patients with recurrent thymic tumors. The aim of this study is to evaluate the surgical outcomes for recurrent thymic epithelial tumors based on the Japanese nationwide database. From the database of patients whose thymic epithelial tumors were treated surgically from 1991 through 2010, the cohort who developed recurrence after the initial resection was extracted. Clinicopathological factors were reviewed, and the prognostic factors of re-resected cases were examined. Twenty-eight hundred thirty-five patients who underwent surgical resection of thymic epithelial tumors were registered to the database. Among these patients, 420 (14.8%) experienced recurrence. One hundred sixty-two patients were treated surgically and 243 were treated nonsurgically for recurrent disease. The 5- and 10-year postrecurrence survival rates were 82.7% and 68.2%, respectively, in the surgery group and 43.5% and 25.4%, respectively, in the nonsurgery group (p < 0.001). According to univariate analyses, female sex and the pathological Masaoka I-II stage, nonthymic carcinoma, absence of preoperative treatment and longer recurrent-free interval (RFI) were significantly favorable factors for survival in the surgery group. According to the multivariate analysis, nonthymic carcinoma histology and longer RFI were identified to be independent prognostic factors. The surgical outcomes of recurrent thymic epithelial tumors are favorable in selected patients. The role of re-resection may be limited in the setting of thymic carcinoma and/or a short RFI.
(キーワード): Disease-Free Survival / Female / Humans / Japan / Male / Middle Aged / Neoplasm Recurrence, Local / Neoplasms, Glandular and Epithelial / Prognosis / Retrospective Studies / Survival Analysis / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000378
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25247341; ● Search Scopus @ Elsevier (PMID): 25247341; ● Search Scopus @ Elsevier (DOI): 10.1097/JTO.0000000000000378

(DOI: 10.1097/JTO.0000000000000378, PubMed: 25247341) D Kim, J Dai, LY Fai, H Yao, YO Son, L Wang, P Pratheeshkumar, Kazuya Kondo, X Shi and Z Zhang :
Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development.,
2015.

(要約): Hexavalent chromium (Cr(VI)) compounds are well-established lung carcinogens. Epidermal growth factor receptor (EGFR) is a tyrosine kinase transmembrane receptor that regulates cell survival, tumor invasion, and angiogenesis. Our results show that chronic exposure of human bronchial epithelial (BEAS-2B) cells to Cr(VI) is able to cause malignant cell transformation. These transformed cells exhibit apoptosis resistance with reduced poly ADP-ribose polymerase cleavage (C-PARP) and Bax expression and enhanced expressions of Bcl-2 and Bcl-xL. These transformed cells also exhibit reduced capacity of reactive oxygen species (ROS) generation along with elevated expression of antioxidant manganese superoxide dismutase 2 (SOD2). The expression of this antioxidant was also elevated in lung tumor tissue from a worker exposed to Cr(VI) for 19 years. EGFR was activated in Cr(VI)-transformed BEAS-2B cells, lung tissue from animals exposed to Cr(VI) particles, and human lung tumor tissue. Further study indicates that constitutive activation of EGFR in Cr(VI)-transformed cells was due to increased binding to its ligand amphiregulin (AREG). Inhibition of EGFR or AREG increased Bax expression and reduced Bcl-2 expression, resulting in reduced apoptosis resistance. Furthermore, inhibition of AREG or EGFR restored capacity of ROS generation and decreased SOD2 expression. PI3K/AKT was activated, which depended on EGFR in Cr(VI)-transformed BEAS-2B cells. Inhibition of PI3K/AKT increased ROS generation and reduced SOD2 expression, resulting in reduced apoptosis resistance with commitment increase in Bax expression and reduction of Bcl-2 expression. Xenograft mouse tumor study further demonstrates the essential role of EGFR in tumorigenesis of Cr(VI)-transformed cells. In summary, the present study suggests that ligand-dependent constitutive activation of EGFR causes reduced ROS generation and increased antioxidant expression, leading to development of apoptosis resistance, contributing to Cr(VI)-induced tumorigenesis.
(キーワード): Amphiregulin / Animals / Antioxidants / Apoptosis / Arsenic / Base Sequence / Cell Line, Tumor / Chromium / Female / Gene Expression Regulation, Neoplastic / Gene Silencing / Humans / Ligands / Mice / Mice, Inbred BALB C / Mice, Nude / Microscopy, Fluorescence / Molecular Sequence Data / Neoplasm Transplantation / Nickel / Proto-Oncogene Proteins c-bcl-2 / Reactive Oxygen Species / Receptor, Epidermal Growth Factor / Sequence Homology, Nucleic Acid / bcl-2-Associated X Protein
(出版サイトへのリンク): ● Publication site (DOI): 10.1074/jbc.M114.619783
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25477514; ● Summary page in Scopus @ Elsevier: 2-s2.0-84961289625

(DOI: 10.1074/jbc.M114.619783, PubMed: 25477514, Elsevier: Scopus) FC Detterbeck, K Stratton, D Giroux, H Asamura, J Crowley, C Falkson, PL Filosso, AA Frazier, G Giaccone, J Huang, J Kim, Kazuya Kondo, M Lucchi, M Marino, EM Marom, AG Nicholson, M Okumura, E Ruffini and P Schil Van :
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposal for an evidence-based stage classification system for the forthcoming (8th) edition of the TNM classification of malignant tumors,
Sep. 2014.

(要約): A universal and consistent stage classification system, which describes the anatomic extent of a cancer, provides a foundation for communication and collaboration. Thymic epithelial malignancies have seen little progress, in part because of the lack of an official system. The International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group assembled a large retrospective database, a multispecialty international committee and carried out extensive analysis to develop proposals for the 8th edition of the stage classification manuals. This tumor, node, metastasis (TNM)-based system is applicable to all types of thymic epithelial malignancies. This article summarizes the proposed definitions of the T, N, and M components and describes how these are combined into stage groups. This represents a major step forward for thymic malignancies.
(キーワード): Cohort Studies / Evidence-Based Medicine / Humans / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Prognosis / Retrospective Studies / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000290
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25396314; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921817908

(DOI: 10.1097/JTO.0000000000000290, PubMed: 25396314, Elsevier: Scopus) AG Nicholson, FC Detterbeck, M Marino, J Kim, K Stratton, D Giroux, H Asamura, J Crowley, C Falkson, PL Filosso, G Giaccone, J Huang, Kazuya Kondo, M Lucchi, EM Marom, M Okumura, E Ruffini and P Schil Van :
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposals for the T Component for the forthcoming (8th) edition of the TNM classification of malignant tumors.,
Sep. 2014.

(要約): Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.
(キーワード): Humans / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Prognosis / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000303
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25396315; ● Summary page in Scopus @ Elsevier: 2-s2.0-84921747900

(DOI: 10.1097/JTO.0000000000000303, PubMed: 25396315, Elsevier: Scopus) Kazuya Kondo, P Schil Van, FC Detterbeck, M Okumura, D K Giroux Stratton, H Asamura, J Crowley, C Falkson, PL Filosso, G Giaccone, J Huang, J Kim, M Lucchi, M Marino, EM Marom, AG Nicholson and E Ruffini :
The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposals for the N and M components for the forthcoming (8th) edition of the TNM classification of malignant tumors,
Sep. 2014.

(要約): Stage classification is an important underpinning of management of patients with cancer, and rests on a combination of three components: T for tumor extent, N for nodal involvement, and M for more distant metastases. This article details an initiative to develop proposals for the first official stage classification system for thymic malignancies for the 8th edition of the stage classification manuals. Specifically, the results of analysis of a large database and the considerations leading to the proposed N and M components are described. Nodal involvement is divided into an anterior (N1) and a deep (N2) category. Metastases can involve pleural or pericardial nodules (M1a) or intraparenchymal pulmonary nodules or metastases to distant sites (M1b).
(キーワード): Humans / Lymphatic Metastasis / Neoplasm Metastasis / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Prognosis / Survival Analysis / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000291
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25396316; ● Summary page in Scopus @ Elsevier: 2-s2.0-84949117731

(DOI: 10.1097/JTO.0000000000000291, PubMed: 25396316, Elsevier: Scopus) FY Bhora, DJ Chen, FC Detterbeck, H Asamura, C Falkson, PL Filosso, G Giaccone, J Huang, J Kim, Kazuya Kondo, M Lucchi, M Marino, EM Marom, AG Nicholson, M Okumura, E Ruffini and P Schil Van :
The ITMIG/IASLC Thymic Epithelial Tumors Staging Project: A Proposed Lymph Node Map for Thymic Epithelial Tumors in the Forthcoming 8th Edition of the TNM Classification of Malignant Tumors.,
Sep. 2014.

(要約): Although the presence of nodal disease is prognostic in thymic malignancy, the significance of the extent of nodal disease has yet to be defined. Lymph node dissection has not been routinely performed, and there is currently no node map defined for thymic malignancy. To establish a universal language for reporting as well as characterize the staging of this disease more accurately, an empiric node map is proposed here. This was developed using prior classification systems, series reporting specifics of nodal involvement, anatomical studies of lymphatic drainage, and preexisting node maps of the chest as defined by the International Association for the Study of Lung Cancer and the neck as defined by the American Academy of Otolaryngology-Head and Neck Surgery and the American Society for Head and Neck Surgery. The development of this node map was a joint effort by the International Thymic Malignancy Interest Group and the Thymic Domain of the IASLC Staging and Prognostic Factors Committee. It was reviewed and subsequently approved by the members of ITMIG. This map will be used as an adjunct to define node staging as part of a universal stage classification for thymic malignancy. As more data are gathered using definitions set forth by this node map, a revision may be undertaken in the future.
(キーワード): Humans / Lymph Nodes / Lymphatic Metastasis / Neoplasms, Glandular and Epithelial / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000293
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25396317; ● Summary page in Scopus @ Elsevier: 2-s2.0-84924751110

(DOI: 10.1097/JTO.0000000000000293, PubMed: 25396317, Elsevier: Scopus) Kazuya Kondo :
Therapy for thymic epithelial tumors,
Jun. 2014.

(要約): Thymoma is the most common tumor of the anterior mediastinum. This tumor is associated with unique paraneoplastic syndromes. The rarity of this tumor has somewhat obscured the optimal treatment for this disease. The World Health Organization classification system, which published in 1999, appears to be an advance in our understanding of thymoma. The Masaoka classification is now the most widely accepted and is an excellent predictor of the prognosis of thymoma. Now the International Thymic Malignancy Interest Group is currently engaged in the development of a validated formal TNM classification system for thymic malignancies. The optimal treatment of thymoma is performed according to its clinical stage. Surgery remains the mainstay of treatment for thymic epithelial tumors. Minimally invasive surgery including thoracoscopic surgery and robotic surgery for stage I and II thymomas is increasing now. The value of postoperative radiotherapy in completely resected stage II or III tumors is questionable. As thymomas have a moderate response rate to chemotherapy or radiotherapy, multimodality therapy involving surgery, chemotherapy and radiotherapy appears to increase the rate of complete resection and survival in the advanced (stage III and IV) thymomas.
(キーワード): Combined Modality Therapy / Humans / Mediastinum / Neoplasm Invasiveness / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Prognosis / Radiotherapy, Adjuvant / Thoracoscopy / Thymectomy / Thymus Neoplasms / Treatment Outcome / World Health Organization
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-014-0420-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24913632; ● Search Scopus @ Elsevier (PMID): 24913632; ● Search Scopus @ Elsevier (DOI): 10.1007/s11748-014-0420-z

(DOI: 10.1007/s11748-014-0420-z, PubMed: 24913632) FC Detterbeck, AG Nicholson, Kazuya Kondo, P Schil Van and C Moran :
The Masaoka-Koga stage classification for thymic malignancies clarification and definition of terms,
Feb. 2014.

(キーワード): History, 20th Century / History, 21st Century / Humans / Terminology as Topic / Thymoma / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.3779/j.issn.1009-3419.2014.02.03
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24581156; ● Search Scopus @ Elsevier (PMID): 24581156; ● Search Scopus @ Elsevier (DOI): 10.3779/j.issn.1009-3419.2014.02.03

(DOI: 10.3779/j.issn.1009-3419.2014.02.03, PubMed: 24581156) FC Detterbeck, H Asamura, J Crowley, C Falkson, G Giaccone, D Giroux, J Huang, J Kim, Kazuya Kondo, M Lucchi, M Marino, EM Marom, A Nicholson, M Okumura, E Ruffini, P Schil van and K Stratton :
The IASLC/ITMIG thymic malignancies staging project: development of a stage classification for thymic malignancies.,
Dec. 2013.

(要約): The lack of an official-stage classification system for thymic malignancies is an issue that hampers progress in this rare disease. A collaborative effort by the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group is underway to develop proposals for such a system. A database of more than 10,000 cases worldwide has been assembled to provide a solid basis for analysis. This report outlines the structure of the effort and the process that has been designed.
(キーワード): Humans / International Agencies / Lung Neoplasms / Neoplasm Staging / Program Development / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0000000000000017
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24389429; ● Search Scopus @ Elsevier (PMID): 24389429; ● Search Scopus @ Elsevier (DOI): 10.1097/JTO.0000000000000017

(DOI: 10.1097/JTO.0000000000000017, PubMed: 24389429) 近藤和也 :
(第II章)がんに対する術式決定とインフォームドコンセント肺がん患者の術式決定とインフォームドコンセント,
2013年.

論文

Wise T F James and Kazuya Kondo :
Increased Lipogenesis Is Important for Hexavalent Chromium-Transformed Lung Cells and Xenograft Tumor Growth,
International Journal of Molecular Sciences, Vol.24, No.23, 17060, 2023.

(要約): Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased expression of key lipogenesis proteins (ATP citrate lyase [ACLY], acetyl-CoA carboxylase [ACC1], and fatty acid synthase [FASN]). We also determined that the Cr(VI)-transformed cells did not exhibit an increase in fatty acid oxidation or lipid droplets compared to their passage-matched control cells. Additionally, we observed increases in ACLY, ACC1, and FASN in lung tumor tissue compared with normal-adjacent lung tissue (in chromate workers that died of chromate-induced tumors). Next, using a known FASN inhibitor (C75), we treated Cr(VI)-transformed BEAS-2B with this inhibitor and measured cell growth, FASN protein expression, and growth in soft agar. We observed that FASN inhibition results in a decreased protein expression, decreased cell growth, and the inhibition of colony growth in soft agar. Next, using shRNA to knock down the FASN protein in Cr(VI)-transformed BEAS-2B cells, we saw a decrease in FASN protein expression and a loss of the xenograft tumor development of Cr(VI)-transformed BEAS-2B cells. These results demonstrate that FASN is important for Cr(VI)-transformed cell growth and cancer properties. In conclusion, these data show that Cr(VI)-transformation in vitro caused an increase in lipogenesis, and that this increase is vital for Cr(VI)-transformed cells.
(キーワード): Humans / Chromates / Heterografts / Agar / Lipogenesis / Epithelial Cells / Chromium / Cell Transformation, Neoplastic / 発癌 (carcinogenesis) / Lung
(徳島大学機関リポジトリ): ● Metadata: 119247
(出版サイトへのリンク): ● Publication site (DOI): 10.3390/ijms242317060
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38069382; ● Summary page in Scopus @ Elsevier: 2-s2.0-85179322713

(徳島大学機関リポジトリ: 119247, DOI: 10.3390/ijms242317060, PubMed: 38069382, Elsevier: Scopus) Tamaki Ohtani, Hitoshi Ikushima, Yoshimi Bando, Michiko Yamashita, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi :
Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT,
The Journal of Medical Investigation : JMI, Vol.70, No.3,4, 361-368, 2023.

(要約): This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023.
(キーワード): Humans / Mice / Animals / Carcinoma, Non-Small-Cell Lung / Fluorodeoxyglucose F18 / Positron Emission Tomography Computed Tomography / Lung Neoplasms / Radiopharmaceuticals / Positron-Emission Tomography
(徳島大学機関リポジトリ): ● Metadata: 118771
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.361
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940520; ● Search Scopus @ Elsevier (PMID): 37940520; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.361

(徳島大学機関リポジトリ: 118771, DOI: 10.2152/jmi.70.361, PubMed: 37940520) 杉本沙紀, 今井芳枝, 上田伊佐子, 近藤和也, 高開登茂子, 長谷奈生己, 板東孝枝, 髙橋亜希, 井上勇太, 森裕香, 阪本朋香, 蔭山恵美 :
急性期病院で治療を受ける認知症高齢がん患者に対する看護実践とその関連要因,
四国医学雑誌, Vol.79, No.1,2, 79-80, 2023年.

(要約): 急性期病院で治療を受ける認知症高齢がん患者に対する看護実践とその関連要因を明らかにすることを目的とした．2021年5月∼7月に認知症高齢がん患者の看護経験を有する400名に無記名自記式質問紙調査を行った．急性期病院で治療を受ける認知症高齢がん患者に対する看護実践を構成する因子は「患者が自分の状態の安全を管理できないところを配慮する」「患者の日常性を維持させていくための工夫をする」が生成された．重回帰分析の結果，急性期病院で治療を受ける認知症高齢がん患者に対する看護実践には，「看護師経験年数」「認知症高齢がん患者の看護経験年数」「認知症に関する勉強会・研修会参加」[認知症に関する知識状況]，[認知症看護実践]，[看護師としての倫理的行動力]が関連していた．
(徳島大学機関リポジトリ): ● Metadata: 118420
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390578141487813888

(徳島大学機関リポジトリ: 118420, CiNii: 1390578141487813888) Linwan Zhang, Kazuya Kondo, Takae Bando, Naoya Kawakita, Hiroaki Toba, Yoshie Imai and Hiromitsu Takizawa :
Assessment of dyspnea, ADL, and QOL in the perioperative period in lung cancer patients treated with minimally invasive surgery,
The Journal of Medical Investigation : JMI, Vol.70, No.3.4, 388-402, 2023.

(要約): Patients with lung cancer generally undergo minimally invasive surgery, such as video-assisted thoracoscopic surgery (VATS). This study examined the changes in health conditions and symptoms of patients with lung cancer using the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire (EORTC QLQ) C-30 questionnaires after surgery. This was a longitudinal descriptive study. One hundred and three patients with lung cancer who underwent lung resection at Tokushima University Hospital between 2012 and 2021 were eligible. They completed EORTC QLQ-C30, QLQ-LC13, the Cancer Dyspnea scale (CDS), and pulmonary-ADL (P-ADL) before and 1, 3, and 6 months after surgery. Regarding functional scale scores, impairments in physical and role functions persisted for 6 months after surgery. In symptom scale scores, fatigue, pain, dyspnea, and appetite loss continued for 6 months after surgery. In CDS, sense of effort, discomfort, and total dyspnea scale scores were elevated for 6 months after surgery. In P-ADL, most ADL were impaired 1 month after surgery, but recovered by 3 months. The dyspnea index of ADL was lower for 6 months after surgery. Impairments in health conditions and symptoms persisted for 6 months after surgery despite its minimally invasive nature. J. Med. Invest. 70 : 388-402, August, 2023.
(キーワード): Humans / Lung Neoplasms / Quality of Life / Activities of Daily Living / Dyspnea / Perioperative Period / Minimally Invasive Surgical Procedures / Surveys and Questionnaires
(徳島大学機関リポジトリ): ● Metadata: 118780
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.388
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37940523; ● Search Scopus @ Elsevier (PMID): 37940523; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.388

(徳島大学機関リポジトリ: 118780, DOI: 10.2152/jmi.70.388, PubMed: 37940523) Batkhishig Munkhjargal, Kazuya Kondo, Soejima Shiho, Tegshee Bilguun, Chikako Takai, Naoya Kawakita, Hiroaki Toba and Hiromitsu Takizawa :
Aberrant methylation of dipeptidyl peptidaselike 6 as a potential prognostic biomarker for lung adenocarcinoma,
Oncology Letters, Vol.25, No.5, 206, 2023.

(要約): We previously performed the genome-wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non-tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase-like 6 () has been identified as the most significantly hypermethylated CGI in LADC. is a protein that modulates A-type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper- and hypomethylation, respectively. The present study investigated the methylation and expression levels of and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription-quantitative PCR, respectively. The DNA methylation and mRNA expression levels of were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease-free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients.
(徳島大学機関リポジトリ): ● Metadata: 119342
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2023.13792
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37123021; ● Search Scopus @ Elsevier (PMID): 37123021; ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2023.13792

(徳島大学機関リポジトリ: 119342, DOI: 10.3892/ol.2023.13792, PubMed: 37123021) Naoya Kawakita, Hiroaki Toba, Shin-ichi Sakamoto, Naoki Miyamoto, Mika Takashima, Yukikiyo Kawakami, Kazuya Kondo and Hiromitsu Takizawa :
Cone-beam computed tomography-guided endobronchial ultrasound using an ultrathin bronchoscope for diagnosis of peripheral pulmonary lesions: a prospective pilot study,
Journal of Thoracic Disease, Vol.15, No.2, 579-588, 2023.

(要約): Multimodal transbronchial biopsy (TBB) may have improved diagnostic yield for peripheral pulmonary lesions suspected as lung cancer. Radial endobronchial ultrasound (R-EBUS) provides real-time imaging and confirmation of the location of the lesions. Cone-beam computed tomography (CBCT) can confirm that the forceps tip has reached the lesion before biopsy. Patients with peripheral pulmonary lesions and a positive computed tomography (CT) bronchus sign (based on slice thickness of 1 mm) were prospectively enrolled. An ultrathin bronchoscope (UTB) and R-EBUS probe were advanced to the target bronchus. Thereafter, forceps were advanced, and CBCT was performed. R-EBUS was performed for re-navigation, if possible. The obtained EBUS and CBCT images were classified into "within" (type 1), "adjacent to" (type 2), or "far from" (type 3), based on the probe or forceps tip. For 20 lesions, the diagnostic yield was 85%. The primary EBUS images were of types 1, 2, and 3 in 12, 6, and 2 cases, respectively. The primary CBCT images were of types 1, 2, and 3 in 12, 6, and 2 cases, respectively. Primary EBUS and CBCT image types were equivalent in 14 cases. Of the 12 cases with type 1 primary EBUS image, 9 cases had a type 1 primary CBCT image, while 3 cases exhibited positional misalignment of the forceps tip. Re-navigation was required in 8 cases with types 2 and 3 primary CBCT images. CBCT-guided TBB using an UTB and EBUS may enable real-time positioning guidance and better re-navigation in the diagnosis of peripheral pulmonary lesions.
(徳島大学機関リポジトリ): ● Metadata: 119436
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd-22-1369
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36910050; ● Summary page in Scopus @ Elsevier: 2-s2.0-85149631219

(徳島大学機関リポジトリ: 119436, DOI: 10.21037/jtd-22-1369, PubMed: 36910050, Elsevier: Scopus) Leqi Sun, Kazuya Kondo, Takae Bando and Yoshie Imai :
Resillience in cancer care : What should nurses do?,
The Journal of Medical Investigation : JMI, Vol.70, No.1,2, 1-6, 2023.

(要約): Cancer is a serious threat to human health worldwide. Attention to the quality of life (QoL) of cancer patients is increasingly recognized as an important component of and a fundamental task in cancer care. Recent studies illustrate that resilience is a key biological factor affecting cancer patients' health status and QoL. However, few studies have focused on resilience during medical procedures of cancer patients from the perspective of nursing. In this study, we summarize recent literature exploring the clinical significance of resilience in oncology nursing, propose strategies for cancer care to improve the QoL of patients through interventions on resilience, and focus on emerging theories in oncology nursing. In summary, this will emphasize the importance of resilience in oncology nursing and benefit the clinical practices that improve patients' QoL and reduce the social burden caused by cancer. J. Med. Invest. 70 : 1-6, February, 2023.
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164702; ● Summary page in Scopus @ Elsevier: 2-s2.0-85158830413

(DOI: 10.2152/jmi.70.1, PubMed: 37164702, Elsevier: Scopus) Takae Bando, Kazuya Kondo, Misuzu Matsumoto, Shizuka Kuroshima, Hiromitsu Takizawa, Yoshie Imai, Aki Takahashi and Isako Ueta :
Psychological Adjustment and Related Factors in Patients with Recurrence/Metastatic Lung Cancer after Curative Surgery,
The Journal of Medical Investigation : JMI, Vol.70, No.1,2, 200-207, 2023.

(要約): The purpose of study was to clarify the psychological adjustment and related factors in lung cancer patients with recurrence/metastasis after curative surgery. Forty-one with lung cancer who were informed of a recurrence/metastasis after curative surgery completed a questionnaire comprised of the Mental Adjustment to Cancer Scale (MAC), Psychological Adjustment scale for Cancer Survivors (PACS), and information pertaining to demographic variables. When healthcare providers intervene in patients with lung cancer that has recurred/metastasized after curative surgery, it is necessary to assess patients' psychological adjustment based on demographic information, such as age, sex, marital status, and employment status, and to provide effective support promptly. Factors associated with psychological adjustment with recurrent/metastatic lung cancer after curative surgery were 1) female, 2) having a job, 3) over 65 years of age, 4) having a spouse, and 5) advanced-stage cancer. There was no difference in psychological adjustment between treatment and the period from cancer incidence to recurrence/metastatic. J. Med. Invest. 70 : 200-207, February, 2023.
(キーワード): 肺癌 (lung cancer) / 外科 (surgery) / psychological adjustment / recurrence/metastasis
(徳島大学機関リポジトリ): ● Metadata: 118352
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.70.200
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37164721; ● Search Scopus @ Elsevier (PMID): 37164721; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.70.200

(徳島大学機関リポジトリ: 118352, DOI: 10.2152/jmi.70.200, PubMed: 37164721) Wang Zhishan, Liu Zulong, Wang Po-Shun, Lin Hsuan-Pei, Rea Matthew, Kazuya Kondo and Yang Chengfeng :
Epigenetic downregulation of O6-methylguanine-DNA methyltransferase contributes to chronic hexavalent chromium exposure-caused genotoxic effect and cell transformation,
Environmental Pollution, Vol.341, 122978, 2023.

(要約): Hexavalent chromium [Cr(VI)] is a common environmental pollutant and chronic exposure to Cr(VI) causes lung cancer and other types of cancer in humans, although the mechanism of Cr(VI) carcinogenesis remains elusive. Cr(VI) has been considered as a genotoxic carcinogen, but accumulating evidence indicates that Cr(VI) also causes various epigenetic toxic effects that play important roles in Cr(VI) carcinogenesis. However, it is not clear how Cr(VI)-caused epigenetic dysregulations contributes to Cr(VI) carcinogenesis. This study investigates whether Cr(VI) epigenetic toxic effect has an impact on its genotoxic effect. It was found that chronic low dose of Cr(VI) exposure time-dependently down-regulates the expression of a critical DNA damage repair protein O-methylguanine-DNA methyltransferase (MGMT), leading to the increases of the levels of the highly mutagenic and carcinogenic DNA lesion O-methylguanine (O-MeG) in human bronchial epithelial BEAS-2B cells. Moreover, the levels of MGMT and O-MeG in chronic Cr(VI) exposure-caused human lung cancer tissues are also significantly lower and higher than that in the adjacent normal lung tissues, respectively. It was further determined that chronic low dose of Cr(VI) exposure-transformed BEAS-2B cells display impaired DNA damage repair capacity and a high sensitivity to the toxicity of the alkylating chemotherapeutic drug Temozolomide. In contrast, stably overexpressing MGMT in parental BEAS-2B cells reverses chronic low dose of Cr(VI) exposure-caused DNA damage repair deficiency and significantly reduces cell transformation by Cr(VI). Further mechanistical studies revealed that chronic low dose of Cr(VI) exposure down-regulates MGMT expression through epigenetic mechanisms by increasing DNA methylation and histone H3 repressive modifications. Taken together, these findings suggest that epigenetic down-regulation of a crucial DNA damage repair protein MGMT contributes significantly to the genotoxic effect and cell transformation caused by chronic low dose of Cr(VI) exposure.
(キーワード): Humans / Down-Regulation / O(6)-Methylguanine-DNA Methyltransferase / Cell Transformation, Neoplastic / Chromium / 発癌 (carcinogenesis) / DNA Damage / Lung Neoplasms / Epigenesis, Genetic
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.envpol.2023.122978
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37995958; ● Summary page in Scopus @ Elsevier: 2-s2.0-85181628524

(DOI: 10.1016/j.envpol.2023.122978, PubMed: 37995958, Elsevier: Scopus) 板東孝枝, 雄西智惠美, 今井芳枝, 髙橋亜希, 近藤和也 :
成人看護学実習において学生が捉えた手術見学実習体験の術後看護への影響,
四国医学雑誌, Vol.77, No.5,6, 221-227, 2021年.

(要約): Aim:To clarify the effects of observing surgery during clinical adult nursing practicum on postoperative nursing from the perspective of students. Methods:Semi-structured interviews were conducted with10students in their third year at a nursing college. The obtained data were qualitatively and inductively analyzed. Results:When observing surgery for the patients they were caring for, the students were aware of[the importance of observing and assessment with the influence of surgery and anesthesia taken into account]. Subsequently, they performed[postoperative pain management based on findings from the observation of actual surgical settings], while providing various approaches, including[Approaches to the promotion of patients' awareness of the current situation in order to prevent postoperative confusion and to protect safety]. Through this process, they developed[a sense of responsibility for nursing care inspired by patients・families' coping behaviors]． Discussion:The experience of observing surgery during clinical training was suggested to help students develop practical insights for care to promote postoperative recovery and a sense of responsibility for nursing care inspired by patients・families' coping behaviors.
(キーワード): adult nursing practicum / nursing student / postoperative nursing / effect
(徳島大学機関リポジトリ): ● Metadata: 117135
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050010776440035072

(徳島大学機関リポジトリ: 117135, CiNii: 1050010776440035072) Yukikiyo Kawakami, Hiromitsu Takizawa, Hiroaki Toba, Naoya Kawakita, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Diversity of lymphatic flow in patients with lung cancer revealed by computed tomography lymphography,
Interactive Cardiovascular and Thoracic Surgery, Vol.33, No.6, 871-878, 2021.

(要約): This study was conducted to verify the optimal extent of lymph node dissection or sampling during lung cancer surgery based on the sentinel node (SN) map created by computed tomography (CT) lymphography. From April 2010 to January 2015, patients with clinical stage I non-small-cell lung cancer, who were candidates for lobectomy or segmentectomy with standard hilar and mediastinal lymph node dissection, and in whom bronchus reached the tumour, were enrolled. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. CT images of the chest were obtained 30 s after 2.5 ml of iopamidol was injected. SNs were identified when the maximum CT attenuation value of the lymph nodes on postcontrast CT images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. SNs were identified in 36 (87.8%) of the 41 patients. The average number of SNs was 1.6 (range, 1-4). There was 1 false negative case; therefore, the accuracy of SN identification was 97.2% (35/36). In 5 (13.9%) of 36 patients, SNs were outside the lobe-specific lymph node station range (#11i from right S1, #7 from right S1, #4R from right S8, #12u from right S8, #7 and #12l from left S1 + 2). CT lymphography demonstrated the diversity of lymphatic spreading patterns and there were cases in which lymph flows are found outside the lymph node dissection range.
(キーワード): Carcinoma, Non-Small-Cell Lung / Contrast Media / Humans / Lung Neoplasms / Lymph Nodes / Lymphography / Neoplasm Staging / Sentinel Lymph Node Biopsy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivab204
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34322701; ● Summary page in Scopus @ Elsevier: 2-s2.0-85121244779

(DOI: 10.1093/icvts/ivab204, PubMed: 34322701, Elsevier: Scopus) Bilguun Tegshee, Kazuya Kondo, Shiho Soejima, Kyoka Muguruma, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
GHSR methylation-dependent expression of a variant ligand and receptor of the ghrelin system induces thymoma tumorigenesis,
Oncology Letters, Vol.22, No.5, 793, 2021.

(要約): Our previous study reported that the DNA methylation of growth hormone secretagogue receptor () was significantly higher in thymoma or thymic carcinoma (TC) than in normal thymic tissue samples. Thymic epithelial tumors (TETs) with higher DNA methylation were associated with significantly worse prognosis than those with lower levels of DNA methylation. Diversified components of the ghrelin- axis may exert opposing effects in cancer progression, depending on the cancer type in question. However, the precise function of the axis remains unclear. In the present study, the mRNA expression of five key components of the ghrelin system [native ligand ghrelin, variant ligand In-1 ghrelin, native receptor GHSR1a, variant receptor GHSR1b and acylation enzyme ghrelin O-acyltransferase (GOAT)] were examined in 58 TET samples by reverse transcription-quantitative PCR, and protein expression of GHSR1a and GHSR1b was assessed in 20 TETs using immunohistochemistry. The results revealed that In-1 ghrelin, GHSR1b (variant forms) and GOAT were more strongly expressed in thymoma compared with thymic-adjacent tissue. By contrast, no significant differences were observed in the expression of ghrelin and GHSR1a (native forms) between thymoma and thymic tissue. The mRNA expression of In-1 ghrelin and GHSR1b (variant forms) was positively associated with methylation in thymoma tissue samples. However, a relationship was not found between ghrelin, GHSR1a or GOAT expression (native forms) and methylation in thymoma. Immunohistochemical analysis revealed that mRNA expression of GHSR1a and GHSR1b generally correlated with expression of the corresponding protein, and that the expression of GHSR1b was increased in advanced-stage TETs. These results indicate that the DNA methylation of is associated with a shift from native expression (ghrelin and GHSR1a) to variant expression (In-1 ghrelin and GHSR1b), which induces the tumorigenesis of thymoma, but not TC.
(徳島大学機関リポジトリ): ● Metadata: 116971
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2021.13054
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34630704; ● Summary page in Scopus @ Elsevier: 2-s2.0-85115236793

(徳島大学機関リポジトリ: 116971, DOI: 10.3892/ol.2021.13054, PubMed: 34630704, Elsevier: Scopus) 森本樹里, 今井芳枝, 板東孝枝, 髙橋亜希, 高開登茂子, 中野あけみ, 長谷奈生己, 近藤和也 :
治療を中止したがん患者がもつ回復への希望に対してジレンマを抱えた看護師の体験,
四国医学雑誌, Vol.77, No.3,4, 123-130, 2021年.

(要約): In this study, the authors clarified experience of nurses with the dilemma toward the wish for recovery of cancer patients who discontinued treatment. An interview survey was performed for 14 nurses who had ever care cancer patients who discontinued their treatment. Experience of nurses with the dilemma toward the wish for recovery of cancer patients who discontinued treatment consisted of the following categories ;[ I am not able to respond to the patient's wish though I want to],[There is difference how to spend the time remained between the patient and me],[I do not have a sufficient power to support the end of the patient's life],[I feel disconsolate being unable to realize the patient's wish for recover]and[I'm a nurse. I never run from my patients]. The nurses with dilemma had experience in facing nursing cares driven by the sense of responsibility as a nurse while holding pain in their heart. Ethical problems may be underlying in this experience, and the need of team work, not individual responses, has been suggested. Therefore, support to reveal experience of nurses in daily nursing care is needed.
(キーワード): cancer patients who have stopped treatment / hope to recover / experience of a nurse with a dilemma
(徳島大学機関リポジトリ): ● Metadata: 116395
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050289864791286912

(徳島大学機関リポジトリ: 116395, CiNii: 1050289864791286912) Hiromitsu Takizawa, Naoki Miyamoto, Shinichi Sakamoto, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Hypervascularized bronchial arteries as a risk factor for intraoperative bleeding and prolonged surgery,
Journal of Thoracic Disease, Vol.13, No.8, 4731-4741, 2021.

(要約): The present study investigated whether highly vascularized bronchial arteries affect the intraoperative blood loss and the operative time of video-assisted thoracic surgery (VATS) lobectomy for patients with non-small cell lung cancer. We retrospectively collected data on consecutive pathological stage I to IIIA non-small cell lung cancer patients who underwent VATS lobectomy with systematic lymph node dissection between January 2017 and December 2019. Patients were divided into the following two groups according to bronchial artery diameters on preoperative enhanced contrast computed tomography (CT) findings: ≤2 and >2 mm groups. Among the 175 patients enrolled, risk factors for intraoperative blood loss >50 mL were being male (P=0.005), a history of smoking (P=0.01), percent forced expiratory volume in 1 s (FEV1.0%) <70% (P=0.012), squamous cell carcinoma (P=0.049), and a bronchial artery diameter >2.0 mm (P<0.001) in the unadjusted analysis, and a bronchial artery diameter >2.0 mm (P<0.001) in the multivariable analysis. Risk factors for an operative time >200 min were being male (P<0.001), a history of smoking (P=0.007), FEV1.0% <70% (P=0.011), squamous cell carcinoma (P=0.046), a bronchial artery diameter >2.0 mm (P<0.001), and experience of surgeon <10 years (P=0.011) in the unadjusted analysis, and being male (P=0.047), a bronchial artery diameter >2.0 mm (P=0.024), and experience of surgeon <10 years (P=0.047) in the multivariable analysis. Bronchial artery diameter was the most important risk factor of intraoperative bleeding and prolonged operative time during VATS lobectomy.
(徳島大学機関リポジトリ): ● Metadata: 116933
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd-21-616
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34527314; ● Summary page in Scopus @ Elsevier: 2-s2.0-85113478594

(徳島大学機関リポジトリ: 116933, DOI: 10.21037/jtd-21-616, PubMed: 34527314, Elsevier: Scopus) Toru Sawada, Hiromitsu Takizawa, Mariko Aoyama, Naoya Kawakita, Naoki Miyamoto, Shinichi Sakamoto, Mika Takashima, Daisuke Matsumoto, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Diagnosis of visceral pleural invasion using confocal laser endomicroscopy during lung cancer surgery,
Journal of Thoracic Disease, Vol.13, No.8, 4742-4752, 2021.

(要約): Visceral pleural invasion (VPI) in lung cancer is a significant prognostic factor; however, it is difficult to diagnose preoperatively or intraoperatively. In this study, we examined the possibility of intraoperative diagnosis of VPI using confocal laser endomicroscopy (CLE). Among patients with primary lung cancer who underwent surgery between April 2018 and August 2019, those in whom the tumor was in contact with the pleura on chest computed tomography and whose pleural changes were intraoperatively confirmed were enrolled in this study. In the 35 patients who underwent lung resection (6 cases with visceral pleural infiltration), the area where pleural change was noted was observed and a short video was recorded using CLE. Based on the video images, three evaluators determined the defect ratio (0%, 25%, 50%, 75%, and 100%) of the autofluorescence-positive structure. The area under the receiver operating characteristic curve was used to evaluate the diagnostic performance for VPI. In 15 cases (3 cases with VPI), a validation study was performed for intraoperative VPI according to the cutoff value of the defect ratio of the autofluorescence-positive structure. The areas under the receiver operating characteristic curve for the defect ratio of the autofluorescence-positive structure were 0.86-0.91 for the three readers. Using defect ratio of autofluorescence-positive structure cutoff of ≥50% as predictor of VPI, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 83.3-100.0%, 57.7-73.1%, 35.3-41.7%, 95.0-100.0%, and 75.0-78.1%, respectively, for the three readers. In the validation study, the sensitivity was 100%, the specificity was 83.3%, and the diagnostic accuracy rate was 86.7%. The diagnosis of VPI through CLE is simple, non-invasive, and has high diagnostic accuracy rates. This method may be applicable for determining surgical procedures.
(徳島大学機関リポジトリ): ● Metadata: 116384
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd-21-137
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34527315; ● Summary page in Scopus @ Elsevier: 2-s2.0-85113558883

(徳島大学機関リポジトリ: 116384, DOI: 10.21037/jtd-21-137, PubMed: 34527315, Elsevier: Scopus) Takae Bando, Kazuya Kondo, Chiemi Onishi, Hiromitsu Takizawa, Yoshie Imai and 山田和代 :
The Development of the Arm Fixation Method to Prevent Ipsilateral Shoulder Pain in Patients Undergoing Lung Resection,
Journal of PeriAnesthesia Nursing, 1-7, 2021.

(要約): The aim of the present study was to investigate the efficacy of a new upper limb fixation method-body pillow position for preventing postoperative ipsilateral shoulder pain (ISP) in patients undergoing lung resection. An experimental study design was used. We conducted two comparisons (group A: the previous position using the arm fixation device; group B: the body pillow position) at random and examined an arm fixation method that is effective for ISP prophylaxis in patients undergoing surgery in the lateral decubitus position. We approached 87 patients, two were excluded, and, thus, 85 were randomly assigned to group A (n = 43) or group B (n = 42). No significant differences were observed in the frequency of ISP between groups A and B (25.6% vs 26.2%). The intensity of ISP between both groups was analyzed by a repeated-measures analysis of variance and was shown to decrease over time in 22 patients (P = .010). The intensity of ISP on postoperative days 0 to 3 was slightly lower in group B than in group A (P = .158). Risk factors for ISP were the duration of surgery (odds ratio, 1.01; 95% confidence interval, 1.00 to 1.01) and pre-existing shoulder stiffness (odds ratio, 5.15; 95% confidence interval, 1.07 to 24.83). There was no significance in the frequency of ISP between group A and group B. The intensity of ISP on postoperative days 0 to 3 was lower in group B than in group A, although there was no significant difference. It is important perspective for perioperative care providers to prevent ISP for early postoperative recovery and improvement of postoperative quality of life. These results suggested that we must consider a better position for preventing postoperative ISP in patients undergoing lung resection.
(キーワード): arm fixation method / ipsilateral shoulder pain / lung resection
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jopan.2020.11.003
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34219013; ● Search Scopus @ Elsevier (PMID): 34219013; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jopan.2020.11.003

(DOI: 10.1016/j.jopan.2020.11.003, PubMed: 34219013) 宮下由佳, 今井芳枝, 板東孝枝, 髙橋亜希, 高開登茂子, 中野あけみ, 長谷奈生己, 近藤和也 :
がん化学療法看護のエキスパートナースが大切にしている実践,
四国医学雑誌, Vol.77, No.1 2, 71-80, 2021年.

(要約): To clarify the practical approaches of nurses in cancer chemotherapy, semi-structured interviews were conducted with 10 nurses certified for cancer chemotherapy in Tokushima Prefecture. The interview data were classified into the following categories : [not neglecting any step, as failure is unacceptable], [accurately predicting the symptoms of chemotherapy, rather than simply waiting for patients to report them], [making efforts to fulfill patients' desire to live], [bearing a heavy responsibility for handling toxic drugs], and [playing a role in generalizing chemotherapy]. The results suggest that the practical approaches of nurses in cancer chemotherapy three features place importance on "achieving positive effects while minimizing risks", "not narrowing down the scope of life", and "reducing resistance to chemotherapy".
(キーワード): Cancer Chemotherapy Nursing / practical approach / nurses certified for cancer chemotherapy
(徳島大学機関リポジトリ): ● Metadata: 116040
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050569845462234752

(徳島大学機関リポジトリ: 116040, CiNii: 1050569845462234752) 今井芳枝, 髙橋亜希, 板東孝枝, 上田伊佐子, 近藤和也 :
看護学生が理解する高齢者看護学実習におけるオレムのパワー構成要素,
四国医学雑誌, Vol.77, No.1 2, 63-70, 2021年.

(要約): The purpose of this study was to analyze trends in nursing students' assessments of the 10 powers of self-care agency in Gerontological Nursing and to identify educational support for students. The subjects were the practice records of 66 third-year nursing students who completed Gerontological Nursing from September 2019 to February 2020. The results showed that they had a perspective of directing their attention to the patient's interest, will, motivation, and reasoning among 10 power items that all students were able to assess, and that they approached their care with a respectful attitude toward the patient's perceptions and intentions for self-care. In addition, it could be inferred that they understood self-care in terms of patients' behaviors and activities by appearance. Conversely, from the items that more than half of the students were unable to assess, it could be inferred that they were unable to assess how to apply self-care agency to the patient's prospect and lives in future.
(キーワード): Nursing Students / Orem's Power Components / Gerontological Nursing Clinical Practice
(徳島大学機関リポジトリ): ● Metadata: 116039
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050569845438372352

(徳島大学機関リポジトリ: 116039, CiNii: 1050569845438372352) Shiho Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, Kyoka Muguruma, B Tegshee, Yukikiyo Kawakami, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
GAD1 expression and its methylation as indicators of malignant behavior in thymic epithelial tumors,
Oncology Letters, Vol.21, No.6, 483, 2021.

(要約): Thymic epithelial tumors (TETs) comprise thymomas and thymic carcinoma (TC). TC has more aggressive features and a poorer prognosis than thymomas. Genetic and epigenetic alterations in thymomas and TC have been investigated in an attempt to identify novel target molecules for TC. In the present study, genome-wide screening was performed on aberrantly methylated CpG islands in thymomas and TC, and the glutamate decarboxylase 1 gene () was identified as the 4th significantly hypermethylated CpG island in TC compared with thymomas. catalyzes the production of γ-aminobutyric acid from L-glutamic acid. expression is abundant in the brain but rare in other tissues, including the thymus. A total of 73 thymomas and 17 TC tissues were obtained from 90 patients who underwent surgery or biopsy at Tokushima University Hospital between 1990 and 2017. DNA methylation was examined by bisulfite pyrosequencing, and the mRNA and protein expression levels of were analyzed using reverse transcription-quantitative PCR and immunohistochemistry, respectively. The DNA methylation levels of were significantly higher in TC tissues than in the normal thymus and thymoma tissues, and methylation exhibited high sensitivity and specificity for discriminating between TC and thymoma. The mRNA and protein expression levels of were significantly higher in TC tissues than in thymomas. Patients with TET with high DNA hypermethylation and high mRNA and protein expression levels had significantly shorter relapse-free survival rates than those with low levels. In conclusion, significantly more epigenetic alterations were observed in TC tissues compared with in thymomas, which may contribute to the clinical features and prognosis of patients.
(徳島大学機関リポジトリ): ● Metadata: 116970
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ol.2021.12744
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33968199; ● Summary page in Scopus @ Elsevier: 2-s2.0-85105632213

(徳島大学機関リポジトリ: 116970, DOI: 10.3892/ol.2021.12744, PubMed: 33968199, Elsevier: Scopus) 澤田徹, 吉田光輝, 梶浦耕一郎, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡の破損を分析する,
気管支学, Vol.43, No.2, 91-96, 2021年.

(要約): 背景．気管支鏡は超音波内視鏡，ステント，気管支充填術，また当科においては，術前コイルマーキングなど，様々な手技に使用されている．同時に，気管支鏡操作も複雑になり，様々な外力がかかることで破損が起こりやすくなる．気管支鏡の故障は医療経済面での不利益のみならず，合併症発生の増加や，修理期間中の検査・治療が中断されることによる患者側の不利益につながる．目的．当院で経験した気管支鏡の破損について検討し，その原因について探求し，今後の予防策や注意点に関して検討する．方法．2015年1月から2017年11月において当科で気管支鏡検査を施行した246例のうち，気管支鏡修理状況について，気管支鏡の種類や破損原因，修理費などについて検討した．結果．246例中3例(4本)の破損を認め，破損率は1.2%であった．気管内レーザー焼灼術による破損の1例(2本)は，吸引鉗子口の先端の熱損傷による破損であった．生検による破損の1例は湾曲部の鉗子操作によるものであり，超音波気管支鏡の破損の1例は，穿刺針による湾曲部の損傷によるものであった．結論．全例が手技的な要因で発生しており，機器の構造の理解不足や手技の不安定さが原因であった．気管支鏡破損は，経済面や安全面，時間的損失に影響を及ぼす．破損を起こさないためには，手技の向上や気管支鏡構造の理解が必要である．我々が取り組む方策は，気管支鏡内部構造の特性の理解，安定した手技の取得に至る講習，教育を常に意識して実行することである．
(キーワード): 破損 / 分析 / 気管支鏡 / 修理 / 故障 / Damage / Analyze / Bronchoscopy / Repair / Breakdown
(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.43.2_91
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390569070681319424; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.43.2_91

(DOI: 10.18907/jjsre.43.2_91, CiNii: 1390569070681319424) Naoya Kawakita, Hiromitsu Takizawa, Hiroaki Toba, Shinichi Sakamoto, Naoki Miyamoto, Daisuke Matsumoto, Mika Takashima, Mitsuhiro Tsuboi, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Cone-beam computed tomography versus computed tomography-guided ultrathin bronchoscopic diagnosis for peripheral pulmonary lesions: A propensity score-matched analysis,
Respirology, Vol.26, No.5, 477-484, 2021.

(要約): CBCT-guided TBB using a UTB under VBN is a useful method for the diagnosis of peripheral small pulmonary lesions. CBCT-guided TBB using UTB under VBN has been used as an alternative to CT-guided TBB. However, the advantage of CBCT-guided TBB using UTB under VBN over CT-guided TBB is still unknown. This study aimed to compare the diagnostic yield of CT-guided TBB and CBCT-guided TBB using a propensity score-matched analysis. Patients with peripheral pulmonary lesions ≤30 mm were included. Lesions whose bronchus could not be determined by CT were excluded. A UTB and biopsy forceps were advanced to the target bronchus under VBN, 2D-fluoroscopy and CT or CBCT. The CT-guided and CBCT-guided groups were matched for their propensity scores based on patient characteristics. We retrospectively reviewed 93 patients in the CT-guided group and 79 patients in the CBCT-guided group for this study. Furthermore, 48 distinct examination pairs were generated by propensity score matching. In the overall diagnostic yield, the CBCT-guided group showed better results (72.9%) than did the CT-guided group (47.9%) (P = 0.012). The median examination time lasted for 43 (IQR: 37-51) min in the CBCT-guided group and 50 (IQR: 43-62) min in the CT-guided group. The examination time in the CBCT-guided group was significantly shorter than that of the CT-guided group (P = 0.001). CBCT-guided TBB had a better diagnostic yield and shorter examination time than did CT-guided TBB.
(キーワード): Bronchoscopy / Cone-Beam Computed Tomography / Humans / Lung Neoplasms / Propensity Score / Retrospective Studies / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/resp.14016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33615626; ● Summary page in Scopus @ Elsevier: 2-s2.0-85101160064

(DOI: 10.1111/resp.14016, PubMed: 33615626, Elsevier: Scopus) Mitsuteru Yoshida, Masao Yuasa, Hirohisa Ogawa, Naoki Miyamoto, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Can Computed Tomography Differentiate Adenocarcinoma In Situ from Minimally Invasive Adenocarcinoma?,
Thoracic Cancer, Vol.12, No.7, 1023-1032, 2021.

(要約): Given the subtle pathological signs of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), effective differentiation between the two entities is crucial. However, it is difficult to predict these conditions using preoperative computed tomography (CT) imaging. In this study, we investigated whether histological diagnosis of AIS and MIA using quantitative three-dimensional CT imaging analysis could be predicted. We retrospectively analyzed the images and histopathological findings of patients with lung cancer who were diagnosed with AIS or MIA between January 2017 and June 2018. We used Synapse Vincent (v. 4.3) (Fujifilm) software to analyze the CT attenuation values and performed a histogram analysis. There were 22 patients with AIS and 22 with MIA. The ground-glass nodule (GGN) rate was significantly higher in patients with AIS (p < 0.001), whereas the solid volume (p < 0.001) and solid rate (p = 0.001) were significantly higher in those with MIA. The mean (p = 0.002) and maximum (p = 0.025) CT values were significantly higher in patients with MIA. The 25th, 50th, 75th, and 97.5th percentiles (all p < 0.05) for the CT values were significantly higher in patients with MIA. We demonstrated that quantitative analysis of 3D-CT imaging data using software can help distinguish AIS from MIA. These analyses are useful for guiding decision-making in the surgical management of early lung cancer, as well as subsequent follow-up.
(キーワード): Adenocarcinoma / Adenocarcinoma in Situ / Aged / Female / Humans / Male / Retrospective Studies / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 116982
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/1759-7714.13838
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33599059; ● Search Scopus @ Elsevier (PMID): 33599059; ● Search Scopus @ Elsevier (DOI): 10.1111/1759-7714.13838

(徳島大学機関リポジトリ: 116982, DOI: 10.1111/1759-7714.13838, PubMed: 33599059) Naoki Miyamoto, Mitsuteru Yoshida, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Hisashi Ishikura and Akira Tangoku :
Classifying the destination of right top pulmonary vein in 31 clinical cases,
General Thoracic and Cardiovascular Surgery, Vol.69, No.8, 1192-1195, 2021.

(要約): Disruption in the flow of blood vessels is of great concern during thoracic surgery. Preoperative 3-dimensional computed tomography facilitates visualization of the exact location and course of blood vessels. The right posterior upper lobe segmental vein, known as the right top pulmonary vein (RTPV), is an anomalous vein beginning at the right upper lobe and running through the posterior surface of the intermediate bronchus. We clinically investigated 31 patients with RTPV who underwent lobectomy or total resection of the right lung in our hospital or related institutions. We classified the final destination of RTPV into four types. The RTPV flowed into the left atrium in 35.5% of cases, superior pulmonary vein in 9.7%, inferior pulmonary vein in 41.9%, and independently into V6 in 12.9%. An RTPV with a diameter ≥ 5 mm was considered a main drainage vein in S2. We should pay attention to the RTPV during right lung lobectomy.
(キーワード): Bronchi / Humans / Lung / Lung Neoplasms / Pulmonary Veins / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-021-01604-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33586095; ● Search Scopus @ Elsevier (PMID): 33586095; ● Search Scopus @ Elsevier (DOI): 10.1007/s11748-021-01604-6

(DOI: 10.1007/s11748-021-01604-6, PubMed: 33586095) Mitsuteru Yoshida, Masao Yuasa, Kazuya Kondo, Mitsuhiro Tsuboi, Naoya Kawakita and Akira Tangoku :
Evaluation of extended thymectomy approaches based on residual fat tissue,
Interactive Cardiovascular and Thoracic Surgery, Vol.32, No.2, 250-255, 2021.

(要約): This study analysed the patterns of extraction ranges, characteristics, advantages and disadvantages of median sternotomy (MS) and subxiphoid (SX) approaches for extended thymectomy. This study included patients with anterior mediastinum tumour and myasthenia gravis who underwent extended thymectomy at our institution between 2015 and 2018. There were 5 MS and 6 SX extended thymectomy surgeries with the VINCENT software. On preoperative computed tomography, the thymus area and fat tissue surrounding the thymus, which were planned for extraction, were traced using VINCENT (Ver. 4.0). We then constructed three-dimensional images and calculated the volumes. Evaluation of the extended thymectomy approach based on the residual fat tissue was required to determine the area of extended thymectomy. No significant differences in operation time (min) [SX: 197.3 ± 34.0, MS: 206.6 ± 91.4, drainage duration (days), SX: 2.2 ± 1.0, MS: 2.2 ± 0.4, hospital stay (days), SX: 11.8 ± 1.2, MS: 13.4 ± 2.1, residual rate (%), SX: 29.9 ± 17.5, MS: 58.7 ± 18.0 (P = 0.0519)] were observed between the 2 groups. Bleeding was significantly lower for SX than for MS. The residual rate was lower for SX than for MS. Considering the amount of the residual fat tissue, the SX approach allows an adequate dissection area for extended thymectomy compared with the MS approach.
(キーワード): Adult / Disease Progression / Humans / Length of Stay / Male / Mediastinal Neoplasms / Mediastinum / Middle Aged / Myasthenia Gravis / Operative Time / Sternotomy / Thoracic Surgery, Video-Assisted / Thymectomy / Thymoma / Thymus Neoplasms / Young Adult
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/icvts/ivaa242
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33236060; ● Summary page in Scopus @ Elsevier: 2-s2.0-85100360202

(DOI: 10.1093/icvts/ivaa242, PubMed: 33236060, Elsevier: Scopus) Yukikiyo Kawakami, Kazuya Kondo, Naoya Kawakita, Hisashi Matsuoka, Hiroaki Toba, Hiromitsu Takizawa, Mitsuteru Yoshida and Akira Tangoku :
Long-term outcomes of sentinel node identification using indocyanine green in patients with lung cancer,
Thoracic Cancer, Vol.12, No.2, 165-171, 2021.

(徳島大学機関リポジトリ): ● Metadata: 116983
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/1759-7714.13737
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33219734; ● Summary page in Scopus @ Elsevier: 2-s2.0-85096745669

(徳島大学機関リポジトリ: 116983, DOI: 10.1111/1759-7714.13737, PubMed: 33219734, Elsevier: Scopus) 吉田光輝, 丹黒章, 東野恒作, 近藤和也, 岩田貴, 赤池雅史, 金山博臣, 鶴尾吉宏 :
【最先端医療を支える解剖学】呼吸器外科における最先端手術手技とCAL(Clinical Anatomy Laboratory),
四国医学雑誌, Vol.76, No.5-6, 225-234, 2020年.

(要約): Recently, endoscopic surgery is the most common procedurein the field of thoracic surgery. The newestthoracic surgeryapproaches are the video-assisted thoracic surgery(VATS), the one-port video-assisted thoracic surgery, and the robotic surgery. The individual advantages and disadvantages of these procedures have been discussed. VATS covers a field of view of the surgical field from the leg to the head. The basic method in performing VATS is that the surgeon operates on the abdominal area of the patient and the assistant expands the surgical field from the patient's back. It is currently the standard surgical procedure. The advantage of one-port VATS is the one port itself and its cosmetic advantages and pain reduction. The advantage of robotic surgery is that it has a clear three-dimensional enlarged field of view and can be performed using the delicate moving robotic arm. However, a good surgical training system should be established for the familiarization of these procedures. The clinical anatomy laboratory is the most efficient surgical training in addition to dry and wet lab training. Our institution has fresh-frozen cadavers, which are rare in Japan. The participating thoracic surgeons underwent training for VATS lobectomy, subxiphoid extended thymectomy, and pleurectomy decortication. This training is beneficial for educational and clinical purposes. In the future, we must obtain consistent surgical education before and after graduation using fresh-frozen cadavers. At the same time, a good organ model for training is also necessary. The surgeon has to cooperate with anatomy doctors for the development of a good surgical organ model. For the development of future surgical medicine, surgical training programs should be implemented.
(キーワード): thoracic surgery / fresh frozen cadaver / surgical training
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050005888447565312

(CiNii: 1050005888447565312) Daisuke Matsumoto, Hiroaki Toba, Kazuya Kondo and Akira Tangoku :
Thoracoscopic lobectomy for lung cancer with unilateral absence of pulmonary artery,
JTCVS Techniques, Vol.3, 343-345, 2020.

(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.xjtc.2020.06.024
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34317924; ● Search Scopus @ Elsevier (PMID): 34317924; ● Search Scopus @ Elsevier (DOI): 10.1016/j.xjtc.2020.06.024

(DOI: 10.1016/j.xjtc.2020.06.024, PubMed: 34317924) Naoki Miyamoto, Mitsuteru Yoshida, Mitsuhiro Tsuboi, Kenji Otsuka, Yoshimi Bando, Takumi Kakimoto, Naoya Kawakita, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
A case of long-term unchanged calcifying fibrous tumor,
General Thoracic and Cardiovascular Surgery, Vol.68, No.12, 1587-1590, 2020.

(要約): A calcifying fibrous tumor (CFT) is a rare benign tumor that may occur in any part of the body. We report the case of an asymptomatic 21-year-old woman with thoracic tumors. Chest computed tomography showed multiple masses in the left costophrenic angle. As we were unable to diagnose the tumor with a CT-guided needle biopsy, we performed a thoracoscopic biopsy. We found smooth multilobulated masses on the pleura and multiple small nodules around the main tumors. Partial resection of the tumor was performed by VATS. Histological examination revealed that the tumor had hypocellular fibrosclerotic tissue and distributed psammomatous calcifications with inflammatory infiltrates. Immunohistochemistry demonstrated that the spindle cells were partially positive for CD34 and CD99, but negative for anaplastic lymphoma kinase-1, smooth muscle actin, BCL-2, STAT6, and S-100 protein. The tumor was diagnosed as CFT. The patient's postoperative recovery was uneventful, and no progression of the lesions was observed during follow-up.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-020-01396-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32514881; ● Summary page in Scopus @ Elsevier: 2-s2.0-85086121909

(DOI: 10.1007/s11748-020-01396-1, PubMed: 32514881, Elsevier: Scopus) Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Hiromitsu Takizawa, Yoshimi Bando, Hideki Otsuka, Daisuke Matsumoto, Mika Takashima, Mitsuhiro Tsuboi, Mitsuteru Yoshida, Kazuya Kondo and Akira Tangoku :
Use of a prognostic risk score that aggregates the FDG-PET/CT SUVmax, tumor size, and histologic group for predicting the prognosis of pStage I lung adenocarcinoma,
International Journal of Clinical Oncology, Vol.25, No.6, 1079-1089, 2020.

(要約): pStage I includes clinicopathologically diverse groups. This study aimed to identify the prognostic factors for pStage I lung adenocarcinoma. We retrospectively reviewed 208 patients with pStage I adenocarcinomas who underwent curative resection in our institute between 2006 and 2013. The maximum standardized uptake value (SUVmax) on [F18]-fluoro-deoxy-D-glucose positron emission tomography-computed tomography (PET/CT) was evaluated. Adenocarcinomas were categorized into the following histologic groups: group 0 (minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma), group 1 (papillary predominant adenocarcinoma), and group 2 (acinar predominant adenocarcinoma and all the remaining subtypes). We assessed the relationship between disease-free survival (DFS) and clinicopathological factors. Multivariate analysis of DFS demonstrated that SUVmax > 3.0 (p < 0.001), total tumor size > 20 mm (p = 0.016), and histologic groups (p < 0.05) were independent prognostic factors. The prognostic risk score (PRS) was calculated using the following equation: PRS = SUVmax (≤ 3.0: 0 point, > 3.0: 2 points) + total tumor size (≤ 20 mm: 0 point, > 20 mm: 1 point) + histologic group (group 0: 0 point, group 1: 1 point, group 2: 2 points). Patients were divided into the following three risk groups: low-risk (PRS 0-2 points, n = 136), intermediate-risk (PRS 3-4 points, n = 49), and high-risk groups (PRS 5 points, n = 13). The 5-year DFS rates were 93.2%, 50.6%, and 30.8% for the low-, intermediate-, and high-risk groups, respectively (p < 0.001). The PRS aggregating the FDG-PET/CT SUVmax, total tumor size, and histologic group predicts the prognosis of pStage I lung adenocarcinoma.
(キーワード): Adenocarcinoma of Lung / Aged / Disease-Free Survival / Female / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Male / Middle Aged / Positron Emission Tomography Computed Tomography / Prognosis / Radiopharmaceuticals / Retrospective Studies / Risk Factors / Tumor Burden
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s10147-020-01637-6
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32130543; ● Summary page in Scopus @ Elsevier: 2-s2.0-85081040433

(DOI: 10.1007/s10147-020-01637-6, PubMed: 32130543, Elsevier: Scopus) Mariko Aoyama, Hiromitsu Takizawa, Tamaki Otani, Seiya Inoue, Naoya Kawakita, Mitsuhiro Tsuboi, Yoshimi Bando, Hisanori Uehara, Kazuya Kondo and Akira Tangoku :
Noninvasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using smallanimal FDGPET/CT,
Oncology Reports, Vol.44, 1709-1716, 2020.

(徳島大学機関リポジトリ): ● Metadata: 115331
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2020.7720
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.3892/or.2020.7720

(徳島大学機関リポジトリ: 115331, DOI: 10.3892/or.2020.7720) 今井芳枝, 板東孝枝, 髙橋亜希, 近藤和也 :
高齢者看護学実習におけるオレム看護理論の活用による看護学生の高齢患者の理解の実態,
四国医学雑誌, Vol.75, No.5 6, 179-184, 2019年.

(要約): The purpose of this study was to clarify how the students understand the older patients based on Orem's nursing theory in Geriatric Nursing Training. The participants were17nursing students in third grade. The interview was carried out using semi-structured interview with students for how they felt older patients. As a result, two categories were extracted ; [ they need limited care for deficient parts]and[they have toughness cultivated through their long life]. The students understood the older patients as having self-caring abilities and thought that limited care should be provided only for deficient parts of patients. Also, they understood older patients as having strength cultivated through their long life. It is necessary for teachers to assess the Self-care agency more severely for students to get hold of mature elements characteristic of older patients.
(キーワード): older patients / 看護学生 (nursing students) / Geriatric Nursing Training
(徳島大学機関リポジトリ): ● Metadata: 114640
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050566774711846656

(徳島大学機関リポジトリ: 114640, CiNii: 1050566774711846656) Reina Kishibuchi, Kazuya Kondo, Shiho Soejima, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
DNA methylation of GHSR, GNG4, HOXD9 and SALL3 is a common epigenetic alteration in thymic carcinoma,
International Journal of Oncology, Vol.56, No.1, 315-326, 2019.

(要約): Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non-synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterations in these types of cancer. In this study, we thus performed genome-wide screening of aberrantly methylated CpG islands in thymoma and thymic carcinoma using Illumina HumanMethylation450 K BeadChip. We identified 92 CpG islands significantly hypermethylated in thymic carcinoma in relation to thymoma and selected G protein subunit gamma 4 (GNG4), growth hormone secretagogue receptor (GHSR), homeobox D9 (HOXD9) and spalt like transcription factor 3 (SALL3), which are related to cancer. We examined the promoter methylation of 4 genes in 46 thymic epithelial tumors and 20 paired thymus tissues using bisulfite pyrosequencing. Promoter methylation was significantly higher in thymic carcinoma than in thymoma and revealed a high discrimination between thymic carcinoma and thymoma in all 4 genes. Promoter methylation was higher in thymic carcinoma than in the thymus. No significant differences were observed in the promoter methylation of GNG4, HOXD9, or SALL3 between thymoma and the thymus. The promoter methylation of the 4 genes was not significantly higher in advanced-stage tumors than in early-stage tumors in all thymic epithelial tumors. Among the 4 genes, relapse-free survival was significantly worse in tumors with a higher DNA methylation than in those with a lower DNA methylation in all thymic epithelial tumors. Moreover, relapse-free survival was significantly worse in thymomas with a higher DNA methylation of HOXD9 and SALL3 than in those with a lower DNA methylation. On the whole, the findings of this study indicated that the promoter methylation of cancer-related genes was significantly higher in thymic carcinoma than in thymoma and the thymus. This is a common epigenetic alteration of high diagnostic value in thymic carcinoma and may be involved in the carcinogenesis of thymic carcinoma. However, epigenetic alterations in the 3 genes, apart from GHSR, are not involved in the tumorigenesis of thymoma.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2019.4915
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31746370; ● Summary page in Scopus @ Elsevier: 2-s2.0-85076979892

(DOI: 10.3892/ijo.2019.4915, PubMed: 31746370, Elsevier: Scopus) Mitsuhiro Tsuboi, Kazuya Kondo, Shiho Soejima, Koichiro Kajiura, Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
Chromate exposure induces DNA hypermethylation of the mismatch repair gene MLH1 in lung cancer,
Molecular Carcinogenesis, Vol.59, No.1, 24-31, 2019.

(要約): Hexavalent chromium is recognized as a human carcinogen. Our previous studies revealed that lung cancer (LC) in chromate-exposed workers (chromate LC) had molecular features of frequent microsatellite instability (MSI), repression of MLH1 level, and aberrant DNA methylation of several tumor-suppressor genes, including MLH1. In the present study, we quantitatively investigated MLH1-promoter methylation status using bisulfite pyrosequencing of paired tumorous/nontumorous tissues from chromate and nonchromate LCs to determine the effect of chromate exposure on MLH1-promoter methylation. The methylation level of MLH1 promoter was significantly higher in chromate LC tumors (P < .001) than nonchromate LC tumors and, among chromate LC, significantly higher in tumorous tissue than nontumorous tissue (P = .004). Moreover, the methylation level of MLH1 promoter in normal lung tissue tended to be higher in chromate LC than nonchromate LC (P = .062). In addition, LC with reduced levels of MLH1 showed significantly higher methylation levels of MLH1 promoter than LC exhibiting normal MLH1 levels (P = .019). Moreover, immunohistochemical analyses determined that levels of SUV39H1, an H3K9me2-related methyltransferase, were higher in chromate LC than nonchromate LC (P = .076). Furthermore, we evaluated three DNA double-strand break-repair genes (MRE11, RAD50, and DNA-PKcs) as possible targets of MSI by fragment-length polymorphism analysis, revealing the mutation frequency of RAD50 as significantly higher in chromate LC than nonchromate LC (P = .047). These results suggest that chromate exposure might induce MLH1 hypermethylation in LC as a mechanism of chromate-induced carcinogenesis.
(キーワード): Aged / Carcinogenesis / Chromates / DNA Methylation / DNA Mismatch Repair / Humans / Lung Neoplasms / Microsatellite Instability / Middle Aged / MutL Protein Homolog 1 / Promoter Regions, Genetic
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mc.23125
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31579968; ● Search Scopus @ Elsevier (PMID): 31579968; ● Search Scopus @ Elsevier (DOI): 10.1002/mc.23125

(DOI: 10.1002/mc.23125, PubMed: 31579968) Mitsuhiro Tsuboi, Kazuya Kondo, Kiyoshi Masuda, Shoichiro Tange, Koichiro Kajiura, Tomohiro Kohmoto, Hiromitsu Takizawa, Issei Imoto and Akira Tangoku :
Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma,
Cancer Medicine, Vol.8, No.9, 4189-4199, 2019.

(要約): In a previous genome-wide screening, we identified hypermethylated CpG islands around glutamate decarboxylase 1 (GAD1) in lung adenocarcinoma (LADC). In this study, we aimed to investigate the methylation and expression status of GAD1 and its prognostic value in patients with LADC. GAD1 methylation and mRNA expression status were analyzed using 33 tumorous and paired non-tumorous LADC samples and publicly available datasets. The prognostic value of GAD1 overexpression was investigated using publicly available datasets of mRNA levels and 162 cases of LADC by immunohistochemistry. The methylation and mRNA expression levels of GAD1, each having a positive correlation, were significantly higher in LADC tumors than in paired non-tumorous tissues. LADC patients with higher GAD1 mRNA expression showed significantly poorer prognosis for overall survival in publicly available datasets. Higher immunoreactivity of GAD1 was significantly associated with the pathological stage, pleural invasion, lymph vessel invasion, and poorer prognosis for cancer-specific and disease-free survival. Multivariate analysis revealed that GAD1 protein overexpression is an independent prognosticator for disease-free survival. GAD1 mRNA and protein expression levels were significant prognostic factors in LADC, suggesting that they might be useful biomarkers to stratify patients with worse clinical outcomes after resection.
(徳島大学機関リポジトリ): ● Metadata: 113692
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cam4.2345
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31207151; ● Summary page in Scopus @ Elsevier: 2-s2.0-85071059073

(徳島大学機関リポジトリ: 113692, DOI: 10.1002/cam4.2345, PubMed: 31207151, Elsevier: Scopus) A.A.Ali Eman, Hiromitsu Takizawa, Naoya Kawakita, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mika Takashima, Daisuke Matsumoto, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo, El-Badrawy Khairy Mohammad and Akira Tangoku :
Transbronchial Biopsy Using an Ultrathin Bronchoscope Guided by Cone-Beam Computed Tomography and Virtual Bronchoscopic Navigation in the Diagnosis of Pulmonary Nodules,
Respiration, Vol.98, No.4, 321-328, 2019.

(要約): Transbronchial biopsy is a safe diagnostic approach for patients with peripheral pulmonary lesions; however, the diagnostic yield is low. This study was conducted to evaluate the feasibility and diagnostic yield of transbronchial biopsy using the combination of an ultrathin bronchoscope, virtual bronchoscopic navigation (VBN), and cone-beam computed tomography (CBCT). Patients with peripheral pulmonary lesions, no >30 mm, with the responsible bronchus, were prospectively included. An ultrathin bronchoscope and biopsy forceps were advanced to the target bronchus under VBN, 2D-fluoroscopy, and CBCT. We categorized the CBCT findings before biopsy into 3 types according to positions of the target lesion and forceps (CBCT target-forceps sign). In type A, the forceps reached the inside of the target lesion. In type C, the forceps could not reach the lesion. When the CBCT findings could not be categorized into either type A or C, the sign was categorized as type B. Although the target lesions were invisible by conventional C-arm fluoroscopy in 29 patients, CBCT visualized all 40 lesions. The overall diagnostic yield was 90.0%, and diagnostic yields for malignant and benign lesions were 92.0 and 86.7%, respectively. Diagnostic yields for CBCT target-forceps sign types A, B, and C were 100, 75.0, and 0%, respectively. Four undiagnosed patients proceeded to other diagnostic procedures based on the CBCT target-forceps sign (type B: n = 2, type C: n = 2) and were correctly diagnosed without delay. Transbronchial biopsy using an ultrathin bronchoscope guided by CBCT and VBN showed a very high yield in the diagnosis of pulmonary nodules.
(出版サイトへのリンク): ● Publication site (DOI): 10.1159/000500228
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31121593; ● Search Scopus @ Elsevier (PMID): 31121593; ● Search Scopus @ Elsevier (DOI): 10.1159/000500228

(DOI: 10.1159/000500228, PubMed: 31121593) Naoya Kawakita, Hiromitsu Takizawa, Toru Sawada, Daisuke Matsumoto, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Indocyanine green fluorescence imaging for resection of pulmonary metastasis of hepatocellular carcinoma,
Journal of Thoracic Disease, Vol.11, No.3, 944-949, 2019.

(要約): Indocyanine green (ICG) accumulates in hepatocellular carcinoma (HCC), and tumor fluorescence can be observed under irradiation with near infrared light (NIR). This study investigated the clinical utility of ICG fluorescence imaging during resection of pulmonary metastases of HCC. From April 2010 to June 2018, six patients with suspected pulmonary metastasis of HCC were enrolled prospectively. Prior to surgery, all patients underwent the ICG hepatic function test following intravenous administration of ICG (0.5 mg/kg body weight). During surgery, metastatic HCC was identified by observation of ICG fluorescence, allowing assessment of the surgical margin. Tumor fluorescence was also evaluated on cut sections. A total of 11 metastatic HCCs were resected in six patients at nine operations. Eight lesions were removed by wedge resection and 3 lesions were managed by lobectomy. During surgery, tumor fluorescence could be confirmed through the visceral pleura in 6 out of 7 lesions treated by wedge resection, while NIR irradiation was difficult for 1 lesion. For these 6 lesions, the median distance from the tumor to the visceral pleura and the median surgical margin were 0 mm (range, 0-2 mm) and 14 mm (range, 11-17 mm), respectively. When cut sections were examined, all tumors emitted fluorescence. All lesions were histologically confirmed to be metastatic HCC. In patients with pulmonary metastasis of HCC, ICG fluorescence imaging is useful for identifying the tumor and securing its margin when the lesion is peripheral and wedge resection is planned.
(徳島大学機関リポジトリ): ● Metadata: 116459
(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd.2019.01.107
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31019784; ● Search Scopus @ Elsevier (PMID): 31019784; ● Search Scopus @ Elsevier (DOI): 10.21037/jtd.2019.01.107

(徳島大学機関リポジトリ: 116459, DOI: 10.21037/jtd.2019.01.107, PubMed: 31019784) Koichiro Kajiura, Shoichiro Takao, Kawano Naoko, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku and Kazuya Kondo :
Evaluation of the components of mediastinal cystic lesions using imaging techniques,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 106-111, 2019.

(要約): To identify and differentiate patients with mediastinal cysts from those with cystic tumors requiring surgery. A total of 36 patients with mediastinal cystic lesions were enrolled. The patients were separated into two groups based on pathological findings : those with mediastinal cysts (n=23) and those with mediastinal tumors (n=13). The cystic components were measured using imaging parameters including mean computed tomography (CT) value, apparent diffusion coefficient (ADC), T1 signal intensity ratio (T1SIratio), and T2 signal intensity ratio (T2SI-ratio), acquired from magnetic resonance imaging (MRI) ; and standardized maximum uptake value (SUVmax) fromF-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT). Both groups were statistically compared. Comparative parameters between the cysts and tumors revealed the following ratios : CT value, 40.9?21.2 versus (vs) 24.8?12.9 (p = 0.019) ;SUVmax, 1.18?0.50 vs 4.32?3.52 (p = 0.003) ; ADC, 3.46?0.96 vs 2.68?0.74 (p = 0.022) ; T1SI-ratio, 1.06?0.60 vs 1.35? 0.92 (p = 0.648) ; T2SI-ratio, 5.40?1.80 vs 4.33?1.58 (p = 0.194). However, there was no correlation between FDG uptake and ADC value. SUVmax fromF-FDG PET/CT and ADC derived from MRI were effective in facilitating preoperative diagnosis to differentiate mediastinal cysts from tumors. However, these examinations may be complementary to one another, not dominant. J. Med. Invest. 66 : 106-111, February, 2019.
(キーワード): Adult / Aged / Aged, 80 and over / Cysts / 女性 (female) / Fluorodeoxyglucose F18 / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / 男性 (male) / Mediastinal Diseases / Mediastinal Neoplasms / Middle Aged / Positron Emission Tomography Computed Tomography
(徳島大学機関リポジトリ): ● Metadata: 113404
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.106
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064920; ● Summary page in Scopus @ Elsevier: 2-s2.0-85065786369

(徳島大学機関リポジトリ: 113404, DOI: 10.2152/jmi.66.106, PubMed: 31064920, Elsevier: Scopus) Tamaki Otani, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kajiura, Haruhiko Fujino, Hideki Otsuka and Hirokazu Miyoshi :
Noninvasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDGPET/CT and CT.,
Oncology Reports, Vol.41, No.1, 447-454, 2019.

(要約): We established patient-like models of lung cancer metastasis by orthotopically implanting human non-small cell lung cancer cell lines into SCID mice. We evaluated the utilities of small-animal computed tomography (CT) and positron-emission tomography-computed tomography (PET/CT) in these models to non-invasively and repeatedly monitor the anticancer effects of cisplatin and erlotinib. We orthotopically implanted three non-small cell lung cancer cell lines, A549, FT821 and PC-9, into SCID mice. These mice were then divided into three groups: Control, cis-diamminedichloroplatinum (II) (CDDP) (7-mg/kg CDDP, single administration intraperitoneally), and erlotinib (25 mg/kg erlotinib/day, oral administration 5 days/week). After treatment initiation, we repeatedly performed PET/CT and CT measurements and assessed anticancer effects based on tumor volumes and FDG uptake. A549 tumors were not affected by CDDP or erlotinib. FT821 tumors were highly responsive to CDDP. PC-9 tumors, which have an epidermal growth factor receptor mutation, were highly responsive to erlotinib. Histological results and metastatic rates correlated with the anticancer effects shown by CT. In our orthotopic SCID mouse lung cancer models, 18FDG-PET/CT and CT imaging non-invasively and repeatedly monitored the efficacies of cisplatin and erlotinib against not only implanted tumors, but also mediastinal lymph node metastases.
(キーワード): Animals / Carcinoma, Non-Small-Cell Lung / Cell Line, Tumor / Cisplatin / Erlotinib Hydrochloride / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Lymph Nodes / Lymphatic Metastasis / 男性 (male) / Mice / Mice, SCID / Positron Emission Tomography Computed Tomography / Positron-Emission Tomography / Tomography, X-Ray Computed / Tumor Burden
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2018.6818
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30365151; ● Summary page in Scopus @ Elsevier: 2-s2.0-85056802482

(DOI: 10.3892/or.2018.6818, PubMed: 30365151, Elsevier: Scopus) Atsuro Saijo, Hisatsugu Goto, Nakano Mayuri, Mitsuhashi Atsushi, Yoshinori Aono, Masaki Hanibuchi, Hirohisa Ogawa, Hisanori Uehara, Kazuya Kondo and Yasuhiko Nishioka :
Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells.,
Cancer Letters, Vol.421, 17-27, 2018.

(要約): Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14 monocytes and have features of both macrophages and fibroblasts. Accumulating evidence has suggested that stromal fibrocytes might promote cancer progression. However, the role of fibrocytes in the CSC niches has not been revealed. We herein report that human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.
(徳島大学機関リポジトリ): ● Metadata: 111437
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.canlet.2018.02.016
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29448000; ● Summary page in Scopus @ Elsevier: 2-s2.0-85042214220

(徳島大学機関リポジトリ: 111437, DOI: 10.1016/j.canlet.2018.02.016, PubMed: 29448000, Elsevier: Scopus) 河北直也, 鳥羽博明, 先山正二, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
選択的肺葉ブロックを用いた肺切除の2例,
四国医学雑誌, Vol.74, No.1,2, 55-60, 2018年.

(要約): There are cases in which one-lung ventilation is difficult due to contralateral lung resection or low lung function. Selective lobar blockade can improve oxygenation compared with one-lung ventilation and secure a good operative field by inducing partial collapse. We report two cases of lung resection involving selective lobar blockade. (Case1) An 80-year-old female had previously undergone right upper and middle lobectomy for multiple lung tumors. Surgery was scheduled to remove a 7‐mm ground glass opacity from the upper left lobe. Oral intubation was performed (inner diameter of intubation tube:8mm). Next, the left upper lobe bronchus was blocked with a7Fr Arndt blocker under bronchoscopy, and partial resection of the left upper lobe was conducted. (Case2) A 75-year-old male had previously undergone right upper lobectomy for pulmonary tuberculosis and had developed right chronic empyema. Surgery was scheduled to remove a 22-mm nodule from the left lingular segment. Oral intubation was performed(inner diameter of intubation tube:8．5mm). Next, the left lingual bronchus was blocked with a7Fr Arndt blocker under bronchoscopy. Left lingular segmentectomy was carried out under thoracoscopic assistance. Intraoperative oxygenation was maintained in both cases, and the release of the block due to hypoxemia was not required in either case.
(キーワード): 肺癌 (lung cancer) / surgery / 麻酔 (anesthesia) / blocker
(徳島大学機関リポジトリ): ● Metadata: 111579
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282813458830208

(徳島大学機関リポジトリ: 111579, CiNii: 1050282813458830208) Zhishan Wang, Jianjun Wu, Brock Humphries, Kazuya Kondo, Yiguo Jiang, Xianglin Shi and Chengfeng Yang :
Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation,
Toxicology and Applied Pharmacology, Vol.342, 22-30, 2018.

(要約): While hexavalent chromium [Cr(VI)] is generally considered as a genotoxic environmental carcinogen, studies showed that Cr(VI) exposure also causes epigenetic changes. However, whether Cr(VI)-caused epigenetic dysregulations plays an important role in Cr(VI) carcinogenicity remain largely unknown. The aim of this study was to determine if chronic low dose Cr(VI) exposure causes epigenetic changes, the underlying mechanism and whether chronic low dose Cr(VI) exposure-caused epigenetic dysregulation contributes causally to Cr(VI)-induced cancer stem cell (CSC)-like property and cell transformation. Two immortalized human bronchial epithelial cell lines (BEAS-2B and 16HBE) were exposed to 0.25 μM of KCrO for 20 and 40 weeks to induce cell transformation, respectively. Cr(VI)-induced epigenetic changes were examined in Cr(VI)-transformed cells and Cr(VI) exposure-caused human lung cancer tissues. Pharmacological inhibitors and gene knockdown experiments were used to determine the role of epigenetic dysregulation in Cr(VI) carcinogenicity. We found that chronic Cr(VI) exposure causes epigenetic dysregulation as evidenced by the increased levels of histone H3 repressive methylation marks (H3K9me2 and H3K27me3) and the related histone-lysing methyltransferases (HMTases). Pharmacological inhibition or knockdown of HMTases reduces H3 repressive methylation marks and malignant phenotypes of Cr(VI)-transformed cells. Moreover, knockdown of HMTases in parental cells significantly reduces chronic Cr(VI) exposure-induced CSC-like property and cell transformation. Further mechanistic study revealed that knockdown of HMTases decreases Cr(VI) exposure-caused DNA damage. Our findings indicate that chronic Cr(VI) exposure increases H3 repressive methylation marks by increasing the related HMTases expression; and that increased expression of HMTases plays a causal role in Cr(VI)-induced CSC-like property and cell transformation.
(キーワード): Animals / Cell Line, Transformed / Cell Transformation, Neoplastic / Chromium / Histone-Lysine N-Methyltransferase / Humans / Mice / Mice, Nude / Neoplastic Stem Cells / Up-Regulation / Xenograft Model Antitumor Assays
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.taap.2018.01.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29391238; ● Summary page in Scopus @ Elsevier: 2-s2.0-85041495832

(DOI: 10.1016/j.taap.2018.01.022, PubMed: 29391238, Elsevier: Scopus) Mitsuhiro Tsuboi, Kazuya Kondo, Hiromitsu Takizawa, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Hisashi Ishikura, Suguru Kimura and Akira Tangoku :
A feasibility study of postoperative adjuvant chemotherapy with fluoropyrimidine S-1 in patients with stage II-IIIA non-small cell lung cancer.,
The Journal of Medical Investigation : JMI, Vol.65, 90-95, 2018.

(要約): Adjuvant chemotherapy with uracil tegafur (UFT) improved survival among patients with completely resected stage I lung adenocarcinoma. S-1, an oral dihydropyrimidine dehydrogenase (DPD)-inhibitory 5-fluorouracil, is a more potent DPD inhibitor than UFT;therefore, we hypothesized that postoperative adjuvant chemotherapy with S-1 would be effective for advanced non-small cell lung cancer (NSCLC). We conducted a feasibility study of S-1 as postoperative adjuvant chemotherapy in patients with curatively resected pathological stage bold I back 10 bold I and bold I back 10 bold I back 20 bold I A NSCLC. Adjuvant chemotherapy consisted of 9 courses (4-week administration, 2-week withdrawal) of S-1 at 80-120 mg/body per day. Twenty-four patients with completely resected NSCLC were enrolled in this study from November 2007 through December 2010. The primary endpoint was the rate of completion of the scheduled adjuvant chemotherapy. The secondary endpoints were safety, overall survival, and relapse-free survival. Five patients were censored because of disease recurrence. The planned 9 courses of S-1 were administered to completion in 8 patients. Twelve patients completed more than 70% of the planned courses. Grade 3 adverse reactions, such as elevated total bilirubin (4.2%) and pneumonitis (4.2%), were observed, but there were no Grade 4 adverse reactions. Patients who completed more than 70% of the 9 courses demonstrated better overall survival than those who completed less than 70%. Postoperative administration of S-1 may be possible with few severe adverse events as adjuvant chemotherapy for patients with curatively resected pathological stage bold I back 10 bold I -bold I back 10 bold I back 20 bold I A NSCLC. J. Med. Invest. 65:90-95, February, 2018.
(キーワード): Aged / Carcinoma, Non-Small-Cell Lung / Chemotherapy, Adjuvant / Drug Combinations / Feasibility Studies / Female / Humans / Lung Neoplasms / Male / Middle Aged / Neoplasm Staging / Oxonic Acid / Tegafur
(徳島大学機関リポジトリ): ● Metadata: 111417
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.65.90
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29593202; ● Summary page in Scopus @ Elsevier: 2-s2.0-85044443235

(徳島大学機関リポジトリ: 111417, DOI: 10.2152/jmi.65.90, PubMed: 29593202, Elsevier: Scopus) Takae Bando, Kazuya Kondo, Chiemi Onishi, Koichiro Kajiura, Hiromitsu Takizawa, Yamada Kazuyo, Sato Hiromi and Yoshie Imai :
Ipsilateral shoulder pain in patients following lung resection in the decubitus position,
Journal of Clinical Nursing, Vol.27, No.5-6, 1192-1197, 2017.

(要約): Aims and objectives: To examine the frequency, influencing factors and clinical course of shoulder pain in patients following lung resection. Background: Thoracoscopes have been introduced in the surgical treatment of lung cancer and allow for less invasive surgery with a minimal incision. However, decubitus position-related shoulder pain on the operated side has not yet been investigated. Design: A longitudinal descriptive study. Methods: Patients who underwent lung resection in the decubitus position. Patients were interviewed 2 days before surgery and once daily for 5 days after surgery. Interview items included background data, the concomitant use of epidural anaesthesia, operative duration, the presence of preoperative shoulder stiffness (excluding shoulder pain), type of surgery and site of operation. The intensity of pain was approximately 5 on an 11-point numerical rating scale. Descriptive statistics on patient backgrounds were obtained using SPSS Statistics 22 for Windows. Results: Of the 74 patients who underwent lung resection in a decubitus position, 30 (40.5%) developed shoulder pain on the operated side. The highest rating occurred 1 day after surgery and decreased over time. The following two factors were found to influence shoulder pain on the operated side: operative duration (Z = 2.63; p = .01) and the presence of preoperative shoulder stiffness (excluding shoulder pain) (X²= 4.16; p = .04). Conclusions: This study demonstrated that approximately 40% of patients who underwent lung resection in the decubitus position developed shoulder pain. Relevance to clinical practice: The presence of postoperative shoulder pain was related to both the duration of the operation and to the presence of preoperative shoulder stiffness. Although the shoulder pain resolves within 4 days, it causes the patient additional discomfort and distress. Therefore, further research is needed on positioning for thoracotomy in order to investigate ways to reduce or eliminate this complication of lung surgery.
(キーワード): decubitus position / lobectomy / postsurgery / shoulder pain on the operated side
(徳島大学機関リポジトリ): ● Metadata: 115175
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/jocn.14163
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29148250; ● Summary page in Scopus @ Elsevier: 2-s2.0-85041074012

(徳島大学機関リポジトリ: 115175, DOI: 10.1111/jocn.14163, PubMed: 29148250, Elsevier: Scopus) Naoya Kawakita, Kazuya Kondo, Hiroaki Toba, Akiko Yoneda, Hiromitsu Takizawa and Akira Tangoku :
A case of atypical type A thymoma with vascular invasion and lung metastasis,
General Thoracic and Cardiovascular Surgery, Vol.66, No.4, 239-242, 2017.

(要約): We present a case of type A thymoma with invasion of the left brachiocephalic vein and lung metastases. An 84-year-old man underwent extended thymectomy combined with left brachiocephalic vein reconstruction and resection of a lung metastasis. Histological examination showed vascular invasion by the tumor. The lung metastasis had high mitotic activity and slight nuclear enlargement, the so-called "atypical" features, but the main part of the primary tumor did not. However, the intravascular portion of the tumor had "atypical" histological features like the lung metastasis. It seems that "atypical" histological features are related to clinically malignant behavior.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-017-0794-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28647799; ● Summary page in Scopus @ Elsevier: 2-s2.0-85021236001

(DOI: 10.1007/s11748-017-0794-9, PubMed: 28647799, Elsevier: Scopus) Koichiro Kajiura, Hiromitsu Takizawa, Yuki Morimoto, Kiyoshi Masuda, Mitsuhiro Tsuboi, Reina Kishibuchi, Nuliamina Wusiman, Toru Sawada, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Takuya Naruto, Issei Imoto, Akira Tangoku and Kazuya Kondo :
Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours,
Lung Cancer, Vol.111, 116-123, 2017.

(要約): Aberrant methylation of promoter CpG islands (CGIs) of tumour suppressor genes is a common epigenetic mechanism underlying cancer pathogenesis. The methylation patterns of thymic tumours have not been studied in detail since such tumours are rare. Herein, we sought to identify genes that could serve as epigenetic targets for thymic neuroendocrine tumour (NET) therapy. Genome-wide screening for aberrantly methylated CGIs was performed in three NET samples, seven thymic carcinoma (TC) samples, and eight type-B3 thymoma samples. The methylation status of thymic epithelial tumours (TETs) samples was validated by pyrosequencing in a larger cohort. The expression status was analysed by quantitative polymerase chain reaction (PCR) and immunohistochemistry. We identified a CGI on a novel gene, RASSF1A, which was strongly hypermethylated in NET, but not in thymic carcinoma or B3 thymoma. RASSF1A was identified as a candidate gene statistically and bibliographically, as it showed frequent CGI hypermethylation in NET by genome-wide screening. Pyrosequencing confirmed significant hypermethylation of a RASSF1A CGI in NET. Low-grade NET tissue was more strongly methylated than high-grade NET. Quantitative PCR and immunohistochemical staining revealed that RASSF1A mRNA and protein expression levels were negatively regulated by DNA methylation. RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs. RASSF1A may represent an epigenetic therapeutic target in thymic NET.
(キーワード): Aged / CpG Islands / DNA Methylation / Female / Gene Expression Regulation / Gene Silencing / Humans / Male / Middle Aged / Neuroendocrine Tumors / Promoter Regions, Genetic / RNA, Messenger / Thymus Neoplasms / Tumor Suppressor Proteins
(徳島大学機関リポジトリ): ● Metadata: 112475
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2017.05.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28838380; ● Summary page in Scopus @ Elsevier: 2-s2.0-85025702753

(徳島大学機関リポジトリ: 112475, DOI: 10.1016/j.lungcan.2017.05.019, PubMed: 28838380, Elsevier: Scopus) Koichiro Kajiura, Kiyoshi Masuda, Takuya Naruto, Kohmoto Tomohiro, Watanabe Miki, Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Akira Tangoku and Issei Imoto :
Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma,
Oncotarget, Vol.8, No.2, 2890-2905, 2017.

(要約): In this study, we aimed to identify novel drivers that would be epigenetically altered through aberrant methylation in early-stage lung adenocarcinoma (LADC), regardless of the presence or absence of tobacco smoking-induced epigenetic field defects. Through genome-wide screening for aberrantly methylated CpG islands (CGIs) in 12 clinically uniform, stage-I LADC cases affecting six non-smokers and six smokers, we identified candidate tumor-suppressor genes (TSGs) inactivated by hypermethylation. Through systematic expression analyses of those candidates in panels of additional tumor samples and cell lines treated or not treated with 5-aza-deoxycitidine followed by validation analyses of cancer-specific silencing by CGI hypermethylation using a public database, we identified TRIM58 as the most prominent candidate for TSG. TRIM58 was robustly silenced by hypermethylation even in early-stage primary LADC, and the restoration of TRIM58 expression in LADC cell lines inhibited cell growth in vitro and in vivo in anchorage-dependent and -independent manners. Our findings suggest that aberrant inactivation of TRIM58 consequent to CGI hypermethylation might stimulate the early carcinogenesis of LADC regardless of smoking status; furthermore, TRIM58 methylation might be a possible early diagnostic and epigenetic therapeutic target in LADC.
(キーワード): Adaptor Proteins, Signal Transducing / Adenocarcinoma / Aged / Aged, 80 and over / Animals / 細胞周期 (cell cycle) / Cell Line, Tumor / Cell Proliferation / CpG Islands / DNA Methylation / Disease Models, Animal / Epigenesis, Genetic / Epigenomics / Gene Expression Profiling / Gene Expression Regulation, Neoplastic / Gene Silencing / Genes, Tumor Suppressor / Humans / Lung Neoplasms / Male / Membrane Proteins / Mice / Middle Aged / Neoplasm Staging / Promoter Regions, Genetic / Sequence Analysis, DNA / Ubiquitin
(徳島大学機関リポジトリ): ● Metadata: 110044
(出版サイトへのリンク): ● Publication site (DOI): 10.18632/oncotarget.13761
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27926516; ● Summary page in Scopus @ Elsevier: 2-s2.0-85009811790

(徳島大学機関リポジトリ: 110044, DOI: 10.18632/oncotarget.13761, PubMed: 27926516, Elsevier: Scopus) Hiromitsu Takizawa, Kazuya Kondo, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Koichiro Kajiura, Yukikiyo Kawakami, Shoji Sakiyama, Akira Tangoku, Atsushi Morishita, Yasushi Nakagawa and Toshiyuki Hirose :
Autofluorescence for the diagnosis of visceral pleural invasion in non-small-cell lung cancer,
European Journal of Cardio-Thoracic Surgery, Vol.53, No.5, 987-992, 2017.

(要約): This study was conducted to evaluate the accuracy of autofluorescence as a mode of diagnosis for visceral pleural invasion of non-small-cell lung cancer compared with white-light by means of clinical questions to several thoracic surgeons. Eight independent thoracic surgeons evaluated visceral pleural invasion in 25 cases of non-small-cell lung cancer attached to the visceral pleura on lung windows of preoperative computed tomography images. At the first study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using conventional white-light images, the surgeons diagnosed visceral pleural invasion based on information in preoperative computed tomography images, histological types and videos recorded with white-light mode using a thoracoscope. At the second study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using autofluorescence, the same surgeons diagnosed visceral pleural invasion based on information in 2 videos recorded in white-light mode and in autofluorescence mode using the thoracoscope. The overall average sensitivity, specificity and accuracy of visceral pleural invasion diagnosis by white-light versus autofluorescence mode were 64.6% vs 83.3%, 53.9% vs 73.7% and 56.5% vs 76.0%, respectively. The sensitivity, specificity and accuracy of visceral pleural invasion diagnosis was improved through the additional use of the autofluorescence mode compared with the white-light mode alone.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezx419
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29228249; ● Summary page in Scopus @ Elsevier: 2-s2.0-85047017205

(DOI: 10.1093/ejcts/ezx419, PubMed: 29228249, Elsevier: Scopus) 西野豪志, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 山村佳子, 東雅之 :
肺癌手術における周術期口腔機能管理の術後肺炎予防効果,
日本呼吸器外科学会雑誌, Vol.31, No.4, 432-438, 2017年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.31.432
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.432

(DOI: 10.2995/jacsurg.31.432) Koichiro Kajiura, Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Yukikiyo Kawakami and Akira Tangoku :
A case of subcutaneous emphysema induced by a portable thoracic drainage system after pneumonectomy,
The Journal of the Japanese Association for Chest Surgery, Vol.31, No.5, 610-615, 2017.

(要約): 症例は62歳男性．右肺扁平上皮癌にて術前放射線化学療法後に胸腔鏡補助下右肺全摘術(ND2a-2)を施行した．ポータブル型胸腔ドレナージ装置であるThopazⓇ(トパーズ)にblakeドレーンⓇをつなげて術後胸腔内ドレナージした．術後，咳嗽が多く認められ，皮下気腫が増加した．トパーズのエアリーク表示量はほぼ0 ml/分であった．気管支鏡で気管支断端瘻がないことを確認した．トパーズのドレナージトラブルと判断し，ドレーン抜去すると皮下気腫は軽快した．トパーズには胸腔内圧調節機能があり，胸腔内が過陰圧になるとバルブが開き空気を吸い込ませる機能がある．本症例では咳嗽による急激な胸腔内圧上昇時に胸腔内の空気が皮下に漏れ，その結果起こった胸腔内圧の低下を感知したトパーズ経由で胸腔内へ空気が流入するという機序を繰り返したと考えられた．
(キーワード): ポータブル型胸腔ドレナージ装置 / 肺全摘術後 / 皮下気腫
(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.31.610
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679344397440; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.610

(DOI: 10.2995/jacsurg.31.610, CiNii: 1390282679344397440) 梶浦耕一郎, 先山正二, 近藤和也, 鳥羽博明, 滝沢宏光, 丹黒章 :
胸腺腫摘出術後発症した再生不良性貧血の1例,
日本呼吸器外科学会雑誌, Vol.31, No.6, 815-822, 2017年.

(要約): 胸腺腫には自己免疫性疾患が合併しやすく，時に胸腺腫摘出後に症状が顕在化することがある．胸腺腫摘出後に再生不良性貧血を発症した症例を経験したので報告する．73歳，女性．前縦隔腫瘍にて紹介され，胸骨正中切開で胸腺胸腺腫摘出術を施行した．正岡分類I期，WHO分類はB1であった．術後半年後，肺炎を発症した．術前には正常範囲内であった血液検査で，汎血球減少を認めた．骨髄穿刺にて骨髄の細胞密度は10∼20%，脂肪髄かつ骨髄球/赤芽球の比は5以上であった．Grade 5の再生不良性貧血と診断した．シクロスポリンAを中心とした加療を行ったが，発症4ヵ月後に多臓器不全にて永眠された．胸腺腫摘出後の再生不良性貧血は非常に稀な病態であるが，易感染性となり致死的となりうる．胸腺腫摘出後の経過観察の際には再発のみならず，自己免疫疾患の合併にも注意を必要とする．
(キーワード): 胸腺胸腺腫摘出術後 / 再生不良性貧血
(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.31.815
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204366292992; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.815

(DOI: 10.2995/jacsurg.31.815, CiNii: 1390001204366292992) Kazuya Kondo :
The International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems for thymic epithelial tumors and large-scale retrospective data,
Journal of Thoracic Disease, Vol.8, No.8, 1856-1858, 2016.

(出版サイトへのリンク): ● Publication site (DOI): 10.21037/jtd.2016.05.67
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27619979; ● Search Scopus @ Elsevier (PMID): 27619979; ● Search Scopus @ Elsevier (DOI): 10.21037/jtd.2016.05.67

(DOI: 10.21037/jtd.2016.05.67, PubMed: 27619979) Naoya Kawakita, Hiromitsu Takizawa, Kazuya Kondo, Shoji Sakiyama and Akira Tangoku :
Indocyanine Green Fluorescence Navigation Thoracoscopic Metastasectomy for Pulmonary Metastasis of Hepatocellular Carcinoma,
Annals of Thoracic and Cardiovascular Surgery, Vol.22, No.6, 367-369, 2016.

(要約): Indocyanine green can selectively accumulate in primary hepatocellular carcinoma (HCC) and extrahepatic metastases. We report a patient who underwent resection of pulmonary metastasis of HCC using a thoracoscopic near-infrared imaging system and fluorescent navigation surgery. A 66-year-old man with suspicion of pulmonary metastasis of HCC was referred to our hospital. Indocyanine green was injected intravenously at a dose of 0.5 mg/kg body weight, 20 h before thoracoscopic surgery. An endoscopic indocyanine green near-infrared fluorescence imaging system showed clear blue fluorescence, indicating pulmonary metastasis of HCC in a lingular segment. We performed wide wedge resection using the fluorescence image for navigation to confirm the surgical margins. The specimen was histologically confirmed as a pulmonary metastasis of HCC. In conclusion, thoracoscopic indocyanine green near-infrared fluorescence imaging for pulmonary metastases of HCC is useful in identifying tumor locations and ensuring resection margins.
(キーワード): Aged / Carcinoma, Hepatocellular / Fluorescent Dyes / Humans / Indocyanine Green / Injections, Intravenous / Liver Neoplasms / Luminescent Measurements / Lung Neoplasms / Male / Margins of Excision / Metastasectomy / Pneumonectomy / Predictive Value of Tests / Surgery, Computer-Assisted / Thoracoscopy / Tomography, X-Ray Computed / Treatment Outcome
(徳島大学機関リポジトリ): ● Metadata: 114552
(出版サイトへのリンク): ● Publication site (DOI): 10.5761/atcs.cr.15-00367
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27193496; ● Summary page in Scopus @ Elsevier: 2-s2.0-85006725796

(徳島大学機関リポジトリ: 114552, DOI: 10.5761/atcs.cr.15-00367, PubMed: 27193496, Elsevier: Scopus) Waka Sakai, Naoko Matsui, Mitsuyo Ishida, Takahiro Furukawa, Yoshimichi Miyazaki, Koji Fujita, Ryosuke Miyamoto, Nobuaki Yamamoto, Wataru Sako, Kenta Sato, Kazuya Kondo, Yoshihiko Nishida, Takao Mitsui, Yuishin Izumi and Ryuji Kaji :
Late-onset myasthenia gravis is predisposed to become generalized in the elderly,
eNeurologicalSci, Vol.2, 17-20, 2016.

(徳島大学機関リポジトリ): ● Metadata: 110923
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ensci.2016.02.004
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.ensci.2016.02.004

(徳島大学機関リポジトリ: 110923, DOI: 10.1016/j.ensci.2016.02.004) Koji Nakaya, Hideki Otsuka, Kazuya Kondo, Tamaki Otani and Motoi Nagata :
Tumor growth-inhibitory effect of an angiotensin-converting enzyme inhibitor (captopril) in a lung cancer xenograft model analyzed using 18F-FDG-PET/CT.,
Nuclear Medicine Communications, Vol.37, No.2, 139-146, 2016.

(要約): We administered an angiotensin-converting enzyme inhibitor (captopril) to mice implanted with a human lung adenocarcinoma epithelial cell line (A549 cells) and investigated the tumor growth-inhibitory effect of captopril from the viewpoint of glucose metabolism using (18)F-fluorodeoxyglucose ((18)F-FDG)-PET/CT. Subcutaneous implantation of A549 cells (1.9×10(6) cells) was carried out in the lower right flank of mice. Fifteen days after the transplantation of A549 cells, mice (six in each group) were treated with captopril (3.0 mg/mouse) or saline (1000 μl/mouse) for 5 days. We performed (18)F-FDG-PET/CT imaging of the mice before and after the treatment and evaluated the degree of (18)F-FDG accumulation in tumors. In both groups (the captopril-administrated and control groups), values for the metabolic tumor volume (MTV), maximum standardized uptake value, total lesion glycolysis, and tumor volume after treatment had a tendency to increase. However, tumor growth was suppressed in the captopril-administrated group compared with the control group. In terms of the growth rate, the MTV and tumor volume were significantly different (P<0.05). It was found that captopril exerted a potential tumor growth-inhibitory effect; this was because the captopril-administrated group showed low values of MTV, maximum standardized uptake value, total lesion glycolysis, and tumor volume in comparison with the control group.
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/MNM.0000000000000404
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26465803; ● Summary page in Scopus @ Elsevier: 2-s2.0-84953361815

(DOI: 10.1097/MNM.0000000000000404, PubMed: 26465803, Elsevier: Scopus) 宇山攻, Shoji Sakiyama, Mitsuteru Yoshida, Koichiro Kenzaki, Hiroaki Toba, Yukikiyo Kawakami, Kazumasa Okumura, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model,
The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 182-186, 2016.

(要約): The mortality and morbidity of chronic obstructive pulmonary disease are high. However, no radical therapy has been developed to date. The purpose of this study was to evaluate whether fetal mouse lung tissue can grow and differentiate in the emphysematous lung. Fetal lung tissue from green fluorescent protein C57BL/6 mice at 16 days' gestation was used as donor material. Twelve-month-old pallid mice were used as recipients. Donor lungs were cut into small pieces and implanted into the recipient left lung by performing thoracotomy under anesthesia. The recipient mice were sacrificed at day 7, 14, and 28 after implantation and used for histological examination. Well-developed spontaneous pulmonary emphysema was seen in 12-month-old pallid mice. Smooth and continuous connection between implanted fetal lung tissue and recipient lung was recognized. Air space expansion and donor tissue differentiation were observed over time. We could clearly distinguish the border zones between injected tissue and native tissue by the green fluorescence of grafts. Fetal mouse lung fragments survived and differentiated in the emphysematous lung of pallid mice. Implantation of fetal lung tissue in pallid mice might lead to further lung regeneration research from the perspective of respiratory and exercise function. J. Med. Invest. 63: 182-186, August, 2016.
(徳島大学機関リポジトリ): ● Metadata: 111178
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.63.182
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27644555; ● Summary page in Scopus @ Elsevier: 2-s2.0-84987925398

(徳島大学機関リポジトリ: 111178, DOI: 10.2152/jmi.63.182, PubMed: 27644555, Elsevier: Scopus) 坪井光弘, 三好孝典, 青山万理子, 日野直樹, 先山正二, 近藤和也, 丹黒章 :
難治性有瘻性膿胸に気管支塞栓術を併用した有茎大網充填術が有効であった1例,
気管支学, Vol.38, No.3, 235-240, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.38.3_235
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204740787328; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.38.3_235

(DOI: 10.18907/jjsre.38.3_235, CiNii: 1390001204740787328) 鳥羽博明, 監﨑孝一郎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
急速に増大する巨大気腫性肺囊胞に対して囊胞内吸引後にEWSとフィブリン糊注入で軽快した1例,
気管支学, Vol.38, No.4, 324-327, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.38.4_324
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.38.4_324

(DOI: 10.18907/jjsre.38.4_324) 滝沢宏光, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
胸腔鏡下右上葉切除術の手術時間に影響する因子の検討,
日本呼吸器外科学会雑誌, Vol.30, No.1, 2-7, 2016年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.30.2
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.30.2

(DOI: 10.2995/jacsurg.30.2) 松本大資, 滝沢宏光, 高嶋美佳, 川上行奎, 近藤和也, 丹黒章 :
肺葉切除22年後に胸壁転移を認めたALK融合遺伝子陽性肺癌の1例,
肺癌, Vol.56, No.7, 1046-1050, 2016年.

(要約): 背景．肺癌術後に長期間無再発生存し，遠隔臓器に病変の出現を認めた場合，再発であるか新規病変であるのかを判断するのは困難である．今回われわれは肺葉切除の22年後に出現した胸壁腫瘍に対し，anaplastic lymphoma kinase(ALK)融合遺伝子を検索することにより肺癌の胸壁転移と診断した1例を経験したため，報告する．症例．80歳男性．58歳時に肺腺癌(pT4N2M0 Stage III)に対して左肺上葉切除術を施行した．術後補助化学療法を行い，10年間再発を認めず経過観察を終了した．術後22年目に前胸部の無痛性腫瘤が出現し，生検で腺癌の所見であった．TTF-1陽性，ALK融合遺伝子陽性から肺腺癌の転移が疑われ，初回手術の病理標本もALK融合遺伝子陽性であったことから，胸壁転移と診断した．Crizotinibにて治療し腫瘍は縮小したが，薬剤性間質性肺炎を発症し中止した．プラチナ併用レジメンに変更して加療し，現在も経過観察を継続している．結論．術後遠隔期に再発転移を疑う病変が出現した場合，病理組織診断に加えALK融合遺伝子などの遺伝子変異検索を行うことで診断に至る可能性がある．
(キーワード): 肺癌 / ALK / 遠隔期再発
(出版サイトへのリンク): ● Publication site (DOI): 10.2482/haigan.56.1046
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204683808512; ● Search Scopus @ Elsevier (DOI): 10.2482/haigan.56.1046

(DOI: 10.2482/haigan.56.1046, CiNii: 1390001204683808512) 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
発症予測が困難であった肺癌術後間質性肺炎急性増悪の2例,
四国医学雑誌, Vol.71, No.3,4, 81-86, 2015年.

(要約): Acute exacerbation of interstitial pneumonia (IP) is one of the most severe and fatal postoperative complications in lung cancer patients underlying IP. We treated two patients suffered from acute exacerbation of IP after pulmonary resection for lung cancer. We analyzed their clinical findings. Thoracoscopic lobectomy with mediastinal lymph node dissection was performed in these cases. The patients were diagnosed with acute exacerbation 4 or 5 days after operation and treated with steroids. Both patients had not been diagnosed as IPs before surgery, however, IPs were diagnosed by retrospective analysis of pathological examination for the removal lungs. Chest CT before surgery showed an interstitial shadow in the lung field faintly in these cases. It should be considered that patients who show a faint interstitial shadow in chest CT could potentially cause an acute exacerbation of IP after lung cancer operation.
(キーワード): 肺癌 (lung cancer) / interstitial pneumonia / acute exacerbation
(徳島大学機関リポジトリ): ● Metadata: 109923
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564287688057600

(徳島大学機関リポジトリ: 109923, CiNii: 1050564287688057600) 安原由子, 飯藤大和, 桑村由美, 梅田弥生, 浦西由美, 谷岡哲也, 近藤和也, 岸田佐智, 苛原稔 :
徳島県内の看護職員高度人材育成研修推進事業における特定行為に係る実態調査,
四国医学雑誌, Vol.71, No.3,4, 59-70, 2015年.

(要約): The purpose of this survey was to determine nurse administrators and hospital directors' perspectives about nurses' abilities in performing specific medical practices in hospitals in Tokushima Prefecture. The nurse administrators and hospital directors of all hospitals (113 hospitals) in Tokushima Prefecture were invited to respond to a survey questionnaire by mail posted during the period between February and March of 2015. Responses were received from 46 nurse administrators (response rate, 41%) and 38 hospital directors (response rate, 34%). The obtained data were analyzed using descriptive statistics and the narrative descriptions summarized. Majority of responses from nurse administrators and hospital directors were accepting that nurses have responsibilities for administering medicines such as tranquilizers, anti-anxiety and anticonvulsant drugs. This result was not affected by the size of the hospital, in which fifty four percent (54%) of respondents were from hospitals with less than 100 beds. In Japan, only hospitals with 100 beds or more may have procedures involving highly invasive treatments. Because of this, many of the respondents answered ``not applicable'' to statements in the questionnaire which were related to invasive treatments. Recruitment of nurses, strategies to cope with accidents and education curriculum were important concerns of nurse administrators and hospital directors which remain to be answered in future investigations.
(キーワード): nurses' abilities in performing specific medical practices / Tokushima Prefecture / nurse administrators / hospital directors
(徳島大学機関リポジトリ): ● Metadata: 109920
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812441741824

(徳島大学機関リポジトリ: 109920, CiNii: 1050282812441741824) Tamaki Otani, Hideki Otsuka, Kazuya Kondo, Hiromitsu Takizawa, Motoi Nagata, Mina Kishida and Hirokazu Miyoshi :
Utility of respiratory-gated small-animal PET/CT in the chronologic evaluation of an orthotopic lung cancer transplantation mouse model.,
Radiological Physics and Technology, Vol.8, No.2, 266-277, 2015.

(要約): Our aim in this study was to clarify the effects of respiratory-gated PET in the evaluation of lung cancer according to the (18)F-FDG uptake in an orthotopic transplantation mouse model. We created such a model, and we performed PET/CT. The mice were divided into two groups according to tumor volume: a small-tumor group (<20 mm(3)) and a large-tumor group (>20 mm(3)). We reconstructed the following conditions based on list-mode data: non-gated (3D) images and gated (4D) images, divided based on the respiratory cycle (expiration phase, stable phase, and inspiration phase). We calculated the maximum standardized uptake values (SUVmax) in each phase. We used the % difference [= (4D SUVmax - 3D SUVmax)/3D PET SUVmax × 100 (%)] to evaluate the differences in the 4D SUVmax and 3D SUVmax. The 4D SUVmax values were significantly higher than the 3D SUVmax, regardless of the tumor size. The % difference for the small tumors was greater than that for the large tumors, and it was highest in the stable phase. We conclude that the SUVmax in the stable phase under respiratory-gated PET are the most reliable. The SUVmax observed under non-gated PET are considered to be more frequently underestimated in cases involving small tumors than in those involving large tumors. In the chronologic study evaluating the time course of tumor development, the size of the tumor is small in early stage, and respiratory-gated PET is effective in reducing the underestimation of such tumors caused by respiratory motion.
(徳島大学機関リポジトリ): ● Metadata: 109701
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12194-015-0316-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25921487; ● Summary page in Scopus @ Elsevier: 2-s2.0-84937518832

(徳島大学機関リポジトリ: 109701, DOI: 10.1007/s12194-015-0316-3, PubMed: 25921487, Elsevier: Scopus) Mitsuteru Yoshida, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
Thoracoscopic pericardial fenestration for effective long-term management of non-tuberculous mycobacterium pericarditis,
General Thoracic and Cardiovascular Surgery, Vol.63, No.1, 49-51, 2015.

(要約): The long-term consequences of non-tuberculous mycobacterium pericarditis with pericardial effusion after fenestration have not been described. We encountered a case of non-tuberculous mycobacterium pericarditis in a 59-year-old woman with an underlying collagenosis. Repeated drainage was required because of rapid reaccumulation of the effusion. To definitively control the effusion, pericardial fenestration was performed by video-assisted thoracoscopic surgery. Chest radiography performed 6 years postoperatively showed no accumulation of pericardial or pleural fluid. The patient required careful follow-up and, to date, the pulmonary non-tuberculous mycobacterium (NTM) infection has been successfully suppressed by continuous antibiotic therapy. Pericardial fenestration with antibiotic therapy was an appropriate treatment for recurrent effusion in this case of NTM pericarditis.
(キーワード): Drainage / Female / Humans / Middle Aged / Mycobacterium Infections, Nontuberculous / Pericardial Effusion / Pericardiectomy / Pericarditis / Thoracic Surgery, Video-Assisted
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-013-0273-x
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23800889; ● Summary page in Scopus @ Elsevier: 2-s2.0-84879230822

(DOI: 10.1007/s11748-013-0273-x, PubMed: 23800889, Elsevier: Scopus) 梶浦耕一郎, 滝沢宏光, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
人工呼吸器管理中の慢性有瘻性膿胸に対してEWSを用いた気管支充填術を施行した1例,
気管支学, Vol.37, No.4, 409-413, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.18907/jjsre.37.4_409
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731563264; ● Search Scopus @ Elsevier (DOI): 10.18907/jjsre.37.4_409

(DOI: 10.18907/jjsre.37.4_409, CiNii: 1390282679731563264) 坪井光弘, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
胸腔鏡下気管支動脈結紮を施行した気管支動脈蔓状血管腫の1例,
日本臨床外科学会雑誌, Vol.76, No.10, 2417-2421, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.76.2417
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679827683712; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.76.2417

(DOI: 10.3919/jjsa.76.2417, CiNii: 1390282679827683712) 滝沢宏光, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 森下敦司, 河北直也, 広瀬敏幸 :
肺癌の術中胸膜浸潤診断の正確性についての検討,
日本呼吸器外科学会雑誌, Vol.29, No.5, 576-581, 2015年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.29.576
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204361159936; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.29.576

(DOI: 10.2995/jacsurg.29.576, CiNii: 1390001204361159936) Hisashi Matsuoka, Kazuya Kondo, Hiromitsu Takizawa, Haruhiko Fujino, Etsuko Sakamoto, Junji Uchida, Koh Uyama, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.,
International Journal of Oncology, Vol.46, No.2, 569-577, 2014.

(要約): S-1 is a newly developed dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine that exhibits high clinical efficacy against non-small cell lung cancers. To identify genes that may be associated with chemosensitivity to the antitumor drug S-1, we used a low density array representing 93 genes to analyze expression profiles in 4 orthotopically implanted lung cancers derived from human lung cancer cell lines (Lu99, Lu130, LC6 and A549). The tumor growth inhibition (TGI) rates of S-1 in orthotopically implanted tumors of the Lu99, Lu130, LC6 and A549 cell lines were 34.6, 37.5, 32.1 and 3.6%, respectively. The expression of the PRSS3, ABCC4, TXN, SHMT1 and CMPK genes was significantly promoted in the orthotopically implanted SCID mouse model of the 4 lung cancer cell lines by the administration of S-1, while the expression of the LMO7 and FOLH1 genes was significantly suppressed. The expression of the ABCC1, 2 and TST genes was negatively correlated with TGI. The expression of the TK1 and ERCC2 genes was positively correlated with TGI. The results of the present study suggest that the expression of the ABCC1, 2, TST, TK1 and ERCC2 genes is related to resistance to the antitumor drug S-1.
(キーワード): Animals / Antineoplastic Agents / Cell Line, Tumor / Drug Combinations / Gene Expression Regulation, Neoplastic / Humans / Lung Neoplasms / Mice / Microarray Analysis / Neoplasm Proteins / Oxonic Acid / Tegafur / Xenograft Model Antitumor Assays
(徳島大学機関リポジトリ): ● Metadata: 106443
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/ijo.2014.2754
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25405593; ● Summary page in Scopus @ Elsevier: 2-s2.0-84918509235

(徳島大学機関リポジトリ: 106443, DOI: 10.3892/ijo.2014.2754, PubMed: 25405593, Elsevier: Scopus) Khalil Abdellah Hamed Ali, Hiroaki Toba, Shoji Sakiyama, Ryo Yamamoto, Hiromitsu Takizawa, Koichiro Kenzaki, Kazuya Kondo and Akira Tangoku :
Holter ECG monitoring of sympathovagal fluctuation during bronchoscopy.,
The Clinical Respiratory Journal, 2014.

(要約): Heart rate increased significantly after pre-medication compared with that before pre-medication and increased further during bronchoscopy. The coefficient of variation (CVRR ) values after pre-medication and during bronchoscopy were significantly higher than those before pre-medication (P = 0.031 and P = 0.041, respectively). The low frequency (LF) power decreased during bronchoscopy. LF powers obtained after bronchoscopy were significantly lower than those obtained before bronchoscopy (P < 0.041). The high-frequency (HF) power was found to be decreased during bronchoscopy. In particular, HF powers obtained after bronchoscopy were significantly lower than those obtained before bronchoscopy (P < 0.019). Although the LF/HF ratios increased after pre-medication, they decreased temporarily during the bronchoscope insertion.
(キーワード): ECG / bronchoscopy
(出版サイトへのリンク): ● Publication site (DOI): 10.1111/crj.12204
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25195956; ● Search Scopus @ Elsevier (PMID): 25195956; ● Search Scopus @ Elsevier (DOI): 10.1111/crj.12204

(DOI: 10.1111/crj.12204, PubMed: 25195956) 坪井光弘, 先山正二, 住友弘幸, 坂本晋一, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺葉切除における電動式自動縫合器の使用経験,
四国医学雑誌, Vol.70, No.3-4, 57-60, 2014年.

(要約): Objective : It has been accepted to use staplers for open and video-assisted thoracic surgery, however there was a risk in stapling of the pulmonary vasculatures. A newly developed stapler, powered ECHELON FLEX (Ethicon) is an electrically-powered stapler. It may reduce tip movement during cutting and stapling, which results in reduction of the risk of trauma to surrounding tissue. The aim of this study was to evaluate powered ECHELON FLEX for pulmonary lobectomy. Methods : We reviewed 16 patients who underwent pulmonary lobectomy with powered ECHELON FLEX in our institution from December, 2013 to April, 2014. Results : There were 25 stapling for the pulmonary artery, 17 stapling for the pulmonary vein, 16 stapling for the bronchus, and 33 stapling for the pulmonary parenchyma. Though two case of oozing from the stamps of a pulmonary artery and pulmonary parenchyma, there were no serious complications related to use of the staplers. Conclusions : The powered ECHELON FLEX can be used for pulmonary lobectomy safely.
(キーワード): pulmonary lobectomy / powered stapler
(徳島大学機関リポジトリ): ● Metadata: 109754
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050845762395123840

(徳島大学機関リポジトリ: 109754, CiNii: 1050845762395123840) 滝沢宏光, 先山正二, 梶浦耕一郎, 森下敦司, 西野豪志, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肺癌ロボット手術の私費料金設定,
四国医学雑誌, Vol.70, No.3,4, 51-56, 2014年.

(要約): In Japan, the only robot surgery covered by health insurance is prostatectomy. Robot surgery for pulmonary cancer has not been approved as advanced health care, and hospitals are required to set out-of-pocket fees for surgery on their own. We calculated the fee not covered by insurance to be 1.28million yen, taking into account expenses for : (1) the use of medical equipment, (2) maintenance, (3) labor costs, and (4) medical materials and drugs. Since the fees for surgery plus hospitalization are actually incurred by patients, whether or not the hospitalization fee should be included in out-of-pocket medical fees is decided by each health care institution. In any case, it is necessary to provide patients with a summary of medical fees prior to surgery. Hospitals are required to collect data on pulmonary robot surgical cases while operating the system with medical fees incurred by individual patients.
(キーワード): 肺癌 (lung cancer) / robotic surgery / surgical fee
(徳島大学機関リポジトリ): ● Metadata: 109753
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564287418413056

(徳島大学機関リポジトリ: 109753, CiNii: 1050564287418413056) Mohamed Mokhtar, Yukiko Tadokoro, Misako Nakagawa, Masami Morimoto, Hirokazu Takechi, Kazuya Kondo and Akira Tangoku :
Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA.,
Breast Cancer, 2014.

(要約): SLN were identified by preoperative CTLG and intraoperative SLNB with fluorescence navigation in all patients, the identification rate was 100 %. SLN metastases were detected as positive by OSNA in 9 patients (18 %), 4 were (++), 4 were (+) and 1 was (+I). SLN metastases were detected as positive by histopathology in 10 patients (20 %). The concordance rate between OSNA and permanent sections was 90 %. The negative predictive value of CTLG was 80 %.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s12282-014-0551-1
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25069434; ● Search Scopus @ Elsevier (PMID): 25069434; ● Search Scopus @ Elsevier (DOI): 10.1007/s12282-014-0551-1

(DOI: 10.1007/s12282-014-0551-1, PubMed: 25069434) 滝沢宏光, 丹黒章, 先山正二, 梶浦耕一郎, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 近藤和也 :
特集:Sentinel node navigation surgery Ⅱ．各論 3．肺癌におけるsentinel node navigation surgery,
臨床整形外科, Vol.76, No.4, 371-376, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.15106/J00393.2014127367
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.15106/J00393.2014127367

(DOI: 10.15106/J00393.2014127367) Mohamed Mokhtar, Kazuya Kondo, Hiromitsu Takizawa, Tamaki Otani, Hideki Otsuka, Hitoshi Kubo, Koichiro Kajiura, Yasushi Nakagawa, Yukikiyo Kawakami, Mitsuteru Yoshida, Haruhiko Fujino, Shoji Sakiyama and Akira Tangoku :
Non-invasive monitoring of anticancer effects of cisplatin on lung cancer in an orthotopic SCID mouse model using [¹⁸F] FDG PET-CT.,
Oncology Reports, Vol.31, No.5, 2007-2014, 2014.

(要約): Positron emission tomography-computed tomography (PET-CT) with [18F] fluorodeoxyglucose (FDG) has recently been applied for evaluating tumor response to anticancer therapy. The aim of the present study was to evaluate the utility of FDG PET-CT in monitoring non-invasively and repeatedly the inhibitory effect of cisplatin (CDDP) on an orthotopic lung cancer model. Validation of in vivo FDG uptake in human lung cancer Ma44-3 cell line in an orthotopic SCID mouse model was carried out. Next, we assessed the use of FDG PET-CT to monitor the response of orthotopic lung cancer to the anticancer effect of CDDP. SCID mice were divided into the CDDP group (7 mg/kg single dose intraperitoneally) and the control group. Tumor volume and maximal standardized uptake value (SUV max) were calculated for all mice. All mice were sacrificed for histopathologic analysis. Validation of FDG PET-CT showed that tumor volume and SUV max were significantly correlated with postmortem tumor length measured in specimens (P=0.023) and (P=0.012), respectively, and there was a significant correlation between SUV max and tumor volume (P=0.048). Response monitoring showed that significant growth inhibition by CDDP in the form of SUV max of the CDDP group was significantly lower than that of the control group on day 8 (P=0.02) and on day 13 (P=0.003). Tumor volume of the CDDP group was significantly lower than that of the control group on day 13 (P=0.03). The present study supports using FDG PET-CT in monitoring tumor progression and therapeutic response of lung cancer in an orthotopic model non‑invasively and repeatedly.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or.2014.3056
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24604559; ● Summary page in Scopus @ Elsevier: 2-s2.0-84898640682

(DOI: 10.3892/or.2014.3056, PubMed: 24604559, Elsevier: Scopus) Mohamed Mokhtar, Kazuya Kondo, Toshiaki Namura, Abdellah H.K. Ali, Yui Fujita, Chikako Takai, Hiromitsu Takizawa, Yasushi Nakagawa, Hiroaki Toba, Koichiro Kajiura, Mitsuteru Yoshida, Yukikiyo Kawakami, Shoji Sakiyama and Akira Tangoku :
Methylation and expression profiles of MGMT gene in thymic epithelial tumors,
Lung Cancer, Vol.83, No.2, 279-287, 2014.

(要約): A key challenge in diagnosis and treatment of thymic epithelial tumors (TET) is in improving our understanding of the genetic and epigenetic changes of these relatively rare tumors. Methylation specific PCR (MSP) and immunohistochemistry were applied to 66 TET to profile the methylation status of DNA repair gene O6-methylguanine DNA methyltransferase (MGMT) and its protein expression in TET to clarify the association between MGMT status and clinicopathological features, response to chemotherapy and overall survival. MGMT methylation was significantly more frequent in thymic carcinoma than in thymoma (17/23, 74% versus 13/44, 29%; P<0.001). Loss of expression of MGMT protein was significantly more frequent in thymic carcinoma than in thymoma (20/23, 87% versus 10/44, 23%; P<0.0001). There is a significant correlation between of MGMT methylation and loss of its protein expression (P<0.0003). MGMT methylation and loss of expression were significantly more frequent in advanced thymic epithelial tumors (III/IV) than in early tumors (I/II). MGMT methylation plays a soul role in development of TET, especially in thymic carcinoma. Therefore, translation of our results from basic molecular research to clinical practice may have important implication for considering MGMT methylation as a marker and a target of future therapies in TET.
(キーワード): Adult / Aged / 発癌 (carcinogenesis) / Carcinoma / DNA Methylation / DNA Modification Methylases / DNA Repair Enzymes / Epigenesis, Genetic / Humans / Male / Middle Aged / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Promoter Regions, Genetic / Thymoma / Thymus Neoplasms / Tumor Suppressor Proteins
(徳島大学機関リポジトリ): ● Metadata: 106223
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2013.12.004
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24388682; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892877225

(徳島大学機関リポジトリ: 106223, DOI: 10.1016/j.lungcan.2013.12.004, PubMed: 24388682, Elsevier: Scopus) Naoko Matsui, Izumi Ohigashi, Keijirou Tanaka, Mie Sakata, Takahiro Furukawa, Yasushi Nakagawa, Kazuya Kondo, Tetsuya Kitagawa, Sumimasa Yamashita, Yoshiko Nomura, Yousuke Takahama and Ryuji Kaji :
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia.,
Journal of Neuroimmunology, Vol.269, No.1-2, 56-61, 2014.

(要約): The thymus is implicated as an organ that contributes to autoimmunity in myasthenia gravis (MG) patients. Hassall's corpuscles (HCs) are assumed to represent the terminally differentiated stage of medullary thymic epithelial cells (mTECs). By using multicolor immunohistofluorescence analysis, we examined HCs in thymuses that were therapeutically excised from MG (+) and MG (-) patients. We found that the number of HCs per unit area of the thymic medulla was significantly elevated in the thymuses of MG (+) patients with thymic hyperplasia. CCL21 expression increased in the hyperplastic MG thymuses. We speculate that the altered differentiation of mTECs is associated with the thymic hyperplasia and the onset of MG.
(キーワード): Adult / Aged / Cell Count / Cell Differentiation / Chemokine CCL21 / Epithelial Cells / Female / Humans / Infant / Male / Middle Aged / Myasthenia Gravis / Thymus Hyperplasia
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jneuroim.2014.01.011
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24556356; ● Summary page in Scopus @ Elsevier: 2-s2.0-84896393117

(DOI: 10.1016/j.jneuroim.2014.01.011, PubMed: 24556356, Elsevier: Scopus) 西野豪志, 滝沢宏光, 吉田光輝, 川上行奎, 先山正二, 近藤和也 :
進行肺癌に合併した続発性気胸に対する胸腔内フィブリン糊注入療法の経験,
日本呼吸器外科学会雑誌, Vol.28, No.1, 13-18, 2014年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.28.13
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204361276800; ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.28.13

(DOI: 10.2995/jacsurg.28.13, CiNii: 1390001204361276800) 今井芳枝, 中川美砂子, 雄西智惠美, 板東孝枝, 近藤和也, 森恵子, 丹黒章 :
リンパ浮腫未発症の乳がん術後患者におけるリンパ浮腫予防行動の実態,
JNI : The Journal of Nursing Investigation, Vol.12, No.1, 12-23, 2013年.

(要約): 本研究では，リンパ浮腫未発症の乳がん術後患者におけるリンパ浮腫予防行動の実態調査を行った．対象者は乳房部分切除および腋窩リンパ節郭清を行った乳がん術後患者で，現在外来通院中のリンパ浮腫未発症患者40名に構成的質問紙調査と，その内の21名に面接調査を実施した．結果，リンパ浮腫に関する知識の「リンパ浮腫の病因」，「リンパ浮腫の治療」，「リンパ浮腫の改善方法」，「生活上の注意」，「リンパ浮腫をみた経験」の知識に関して知っているかどうかにより「リンパ浮腫予防法実施状況」で有意差が認められ，継続できるか否かに差があることが示された．また，「リンパ浮腫予防法の数」との間でも有意差が認められ，知識に関して知っているかどうかにより予防法の数に差があることが示された．リンパ浮腫に対する認識および予防行動に対する認識において，それぞれ4つのカテゴリーが抽出された．以上の結果より，未発症患者であるからこそ，自身の体に関心を向け継続していく力をいかにつけていくことが重要となる．そのためにも，患者が体験する日常生活の中から予防法を考案していくことや，実感を伴いながら，知識を意味づけられる予防行動に関する指導を考案していくことが継続の支援に必要である．
(キーワード): 乳がん患者術後患者 / リンパ浮腫未発症 / 予防行動 / Postoperative breast cancer patients / having not developed lymphedema / prevention behavior
(徳島大学機関リポジトリ): ● Metadata: 113192
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050564288205658112

(徳島大学機関リポジトリ: 113192, CiNii: 1050564288205658112) Khasag Narmisheekh, Shoji Sakiyama, Hiroaki Toba, Mitsuteru Yoshida, Yasushi Nakagawa, Hiromitsu Takizawa, Yukikiyo Kawakami, Koichiro Kenzaki, Ali Hamed Khalil Abdellah, Kazuya Kondo and Akira Tangoku :
Monitoring of exhaled carbon monoxide and carbon dioxide during lung cancer operation,
European Journal of Cardio-Thoracic Surgery, Vol.45, No.3, 531-536, 2013.

(要約): Carbon monoxide (CO) is expelled mainly via the lungs, so that exhaled carbon monoxide (Ex-CO) concentration reflects endogenous production. Recent reports have shown that Ex-CO levels are increased in critically ill patients and after anaesthesia and surgery. However, there has been no investigation of the changes in Ex-CO level during a lung operation. We continuously monitored Ex-CO and exhaled carbon dioxide (Ex-CO2) concentrations during surgery for lung cancer. Eighteen lung cancer patients who underwent elective lung cancer lobectomy were enrolled in this study. All patients were endotracheally intubated and ventilated under general anaesthesia. Ex-CO and Ex-CO2 concentrations were separately monitored and recorded continuously using two sets of Carbolyzer® breath analysers (Taiyo Inc., Osaka, Japan). Ex-CO concentration increased rapidly in response to changes in body position from supine to decubitus and was significantly decreased when patients were once again lying back (supine 2). Upon restarting bilateral ventilation, Ex-CO concentration in the operated lung was significantly higher than that in the breathing lung. In the lateral decubitus position, Ex-CO2 concentration showed the same pattern of increase as seen for Ex-CO. In the operated lung, the Ex-CO2 concentrations changed significantly at clamping, declamping and supine 2. In the re-ventilated, operated lung, the Ex-CO2 concentration was significantly lower than in the breathing lung. In the breathing lung, the Ex-CO2 concentration did not exhibit any significant changes over the course of the operation. When breathing was restarted, the Ex-CO level of the target lung was significantly higher than that of the breathing lung. The Ex-CO concentration was also affected by the surgical body position and this change was marked and transient.
(キーワード): Aged / 二酸化炭素 (carbon dioxide) / Carbon Monoxide / Exhalation / Female / Humans / Lung Neoplasms / Male / Middle Aged / Monitoring, Physiologic / Respiration, Artificial
(徳島大学機関リポジトリ): ● Metadata: 105937
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt395
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23913245; ● Summary page in Scopus @ Elsevier: 2-s2.0-84894341845

(徳島大学機関リポジトリ: 105937, DOI: 10.1093/ejcts/ezt395, PubMed: 23913245, Elsevier: Scopus) Hiroaki Toba, Kazuya Kondo, Yohei Sadohara, Hideki Otsuka, Masami Morimoto, Koichiro Kajiura, Yasushi Nakagawa, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama, Yoshimi Bando and Akira Tangoku :
18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.,
European Journal of Cardio-Thoracic Surgery, Vol.44, No.2, e105-e112, 2013.

(要約): OBJECTIVES: The objective of this study was to evaluate the usefulness of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and the relationships among the expressions of hypoxia-inducible factor-1 (HIF-1), glucose transporter-1 (Glut-1) and vascular endothelial growth factor (VEGF), histological type, other clinical factors and FDG uptake in thymic epithelial tumours. METHODS: Thirty-three patients who underwent FDG-PET/CT before treatment were reviewed. All types of tumours were reclassified into three subgroups: low-risk thymomas (types A, AB and B1), high-risk thymomas (types B2 and B3) and thymic carcinomas. Tumour contour, pattern of FDG uptake, tumour size and maximum standardized uptake value (SUVmax) were obtained. Expressions of HIF-1, Glut-1 and VEGF were analysed immunohistochemically, and these expressions were evaluated using grading scales. RESULTS: FDG uptake was visually recognized in all (100%) tumours. A homogeneous pattern of FDG uptake was increasingly observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas (P = 0.016). SUVmax for thymic carcinomas was significantly higher than that for thymomas (P = 0.008). With the optimal cut-off value of SUVmax of 5.6, the sensitivity, specificity and accuracy for diagnosing thymic carcinoma were 0.75, 0.80 and 0.79, respectively. Regarding the mean scoring of HIF-1, Glut-1 and VEGF, increasing trends were observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas. Tumour size revealed a significant correlation with SUVmax (r = 0.60, P < 0.001), and the expression of HIF-1 showed a moderate association, but the expression of Glut-1 showed no correlation with SUVmax. Regarding correlations between the expression of the three markers, there were moderate associations between HIF-1 and Glut-1, and HIF-1 and VEGF, and a significant correlation between Glut-1 and VEGF (r = 0.60, P < 0.001). In type B1 thymoma, HIF-1 and Glut-1 were partly expressed in non-neoplastic immature lymphocytes. CONCLUSIONS: FDG-PET/CT should be performed in patients with tumours in the anterior mediastinum because the pattern of FDG uptake and SUVmax are useful in the differential diagnosis of thymic epithelial tumours. Furthermore, the expressions of HIF-1, Glut-1 and VEGF might be associated with malignancy of thymic epithelial tumours. In contrast, FDG uptake might be dependent on tumour size rather than Glut-1 overexpression.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt263
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23674658; ● Search Scopus @ Elsevier (PMID): 23674658; ● Search Scopus @ Elsevier (DOI): 10.1093/ejcts/ezt263

(DOI: 10.1093/ejcts/ezt263, PubMed: 23674658) Hiroaki Toba, Kazuya Kondo, Takanori Miyoshi, Koichiro Kajiura, Mitsuteru Yoshida, Yukikiyo Kawakami, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Fluoroscopy-assisted thoracoscopic resection after computed tomography-guided bronchoscopic metallic coil marking for small peripheral pulmonary lesions.,
European Journal of Cardio-Thoracic Surgery, 2013.

(要約): OBJECTIVES: To re-evaluate the efficacy of fluoroscopy-assisted thoracoscopic resection after computed tomography (CT)-guided bronchoscopic metallic coil marking (FATS-CM), which was our original method for small peripheral pulmonary lesions. METHODS: Fifty-eight patients with 63 lesions underwent FATS-CM. A metallic coil was installed in the bronchus nearest to the lesion under CT fluoroscopic guidance with ultrathin bronchoscopy. The virtual bronchoscopic navigation (VBN) system was used in 14 cases. Afterwards, we basically performed wide wedge resection (WWR) using a C-arm-shaped roentgenographic fluoroscope during thoracoscopic surgery initially, and then the final procedure was determined by intraoperative histological diagnosis. Moreover, we prospectively treated ground-glass opacity (GGO) lesions of <20 mm diameter according to our treatment protocol from September 2004. RESULTS: We could install coils in the objective bronchi in all cases. The average time required for the marking procedure was 38.9 (15-120) min. Pneumothorax was recognized in 1 (1.7%) case as a complication, but no fatal complications occurred. We could also install coils for each lesion in 4 cases (9 lesions) with multiple lesions. In 14 cases with the VBN system, the examination time and CT number were significantly reduced (P < 0.05 and <0.001, respectively), compared with those of 40 cases without the VBN system. The average interval between the CM and the operation was 5.6 (0-30) days. We never experienced a case of migration preoperatively. Sixty-two (98.4%) lesions were definitively identified, and WWRs were performed using three trocars in 58 (92.1%) cases during thoracoscopic surgery. Lobectomy was initially performed in only 1 case owing to coil migration. Thirty-seven of 40 cases (92.5%) were in line with the treatment protocol. There were no local-regional recurrences in all cases undergoing WWR. CONCLUSIONS: We could prospectively show that our method was suitable to perform WWR with a sufficient margin for small GGO lesions of <20 mm. Moreover, we reconfirmed that the advantages of our method were safety, permitting flexibility in scheduling operations and a high ability to deal with multiple lesions. Additionally, our method became a minimally invasive and mature technique by using a new VBN system.
(出版サイトへのリンク): ● Publication site (DOI): 10.1093/ejcts/ezt220
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23598353; ● Search Scopus @ Elsevier (PMID): 23598353; ● Search Scopus @ Elsevier (DOI): 10.1093/ejcts/ezt220

(DOI: 10.1093/ejcts/ezt220, PubMed: 23598353) 板東孝枝, 雄西智惠美, 今井芳枝, 山田和代, 森恵子, 市原多香子, 近藤和也 :
成人看護学実習における「手術室見学実習観察項目表」を導入した実習の学習効果の検討,
JNI : The Journal of Nursing Investigation, Vol.11, No.1,2, 51-58, 2013年.

(要約): 周手術期看護を体験的に理解することを目標にした成人看護学実習に「手術室見学実習観察項目表」(以下観察項目表とする)を導入して3年になる．この観察項目表は，手術室見学実習時の見学の視点を明確にするために，実習指導に携わる看護師(以下指導者とする)と共同作成したもので，体位固定方法など手術室看護に特有な学習視点としてあげた26項目からなる見学視点ガイドである．学生から研究への使用に同意が得られた観察項目表(学生用)は，2008年は62名(回収率:91%)，2009年は52名(84%)，2010年は56名(95%)であった．指導者から研究への使用に同意が得られた観察項目表(指導者用)は2008年は43名(63%)，2009年は35名(56%)，2010年は58名(98%)であった．これらを分析した結果，26項目のうち，3年間を通して，学生は17項目を80%以上見学できたと答えた．2008年と2010年では[ドレーン挿入]と[出血量の確認]，2009年と2010年では[全身麻酔の導入]と[硬膜外カテーテルの挿入介助]を見学できたと答えた学生の割合が有意に上昇していた(P<0．05)．また，指導者が説明できたと回答した割合が有意に高くなっていた項目は，2008年と2010年では9項目，2009年と2010年では19項目であった．今回の結果から学生が見学できていた項目の割合は3年間で差がない項目がほとんどであったが，指導者が指導できたとする項目は増加していた．また2009年以降観察項目表の導入の効果について5段階評価で確認したところ，約90%の学生が役立ったと回答した．以上のことから，手術室見学実習において，見学する視点を明確にするために「手術室見学実習観察項目表」を導入することは，学生と指導者の双方にとって，手術室見学実習を行う上で見学や指導を行う視点が明確になるため，効果的なツールであるといえる．今後は手術室看護師に分析結果のフィードバックを行い，学生が学習する機会の少ない項目については，ビデオ等の教材などを臨床とともに開発する必要があると考える．
(キーワード): 手術室見学実習 / 看護学生 (nursing students) / 実習指導 / 観察項目標
(徳島大学機関リポジトリ): ● Metadata: 113190
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282813228946432

(徳島大学機関リポジトリ: 113190, CiNii: 1050282813228946432) 吉田みどり, 近藤和也, 中西智子, 多田敏子 :
働く世代の肺がん検診受診行動に関する研究,
四国公衆衛生学会雑誌, Vol.58, No.1, 86-93, 2013年. 池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 後藤正和, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科的治療抵抗性の乳児気管支肉芽に対してHo:YAGレーザー焼灼術を施行した1例,
気管支学, Vol.35, No.2, 222, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204754813696

(CiNii: 1390001204754813696) 古川尊子, 吉田光輝, 梶浦耕一郎, 先山正二, 滝沢宏光, 森本雅美, 武知浩和, 池田真由美, 西野豪志, 中川靖士, 川上行奎, 近藤和也, 丹黒章 :
当科における気管支鏡検査へのLung pointの経験,
気管支学, Vol.35, No.2, 227-228, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731443840

(CiNii: 1390282679731443840) 梶浦耕一郎, 川上行奎, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 中川靖士, 吉田光輝, 滝沢宏光, 田所由紀子, 先山正二, 近藤和也, 丹黒章 :
YAGレーザー使用時の気管支鏡破損の1例,
気管支学, Vol.35, No.2, 228, 2013年.

(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679731441664

(CiNii: 1390282679731441664) 田中義浩, 生島仁史, 近藤和也, 監﨑孝一郎, 坂東良美, 音見暢一, 前澤博 :
非小細胞肺癌に対する術前導入化学放射線療法における画像診断の有用性,
(月刊)臨床放射線, Vol.58, No.1, 222-228, 2013年.

(キーワード): 非小細胞肺癌 / 術前導入化学放射線療法 / 癌画像診断
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1522825130745084544; ● Summary page in Scopus @ Elsevier: 2-s2.0-84873164822

(CiNii: 1522825130745084544, Elsevier: Scopus) 奥田紀久子, 中瀬勝則, 近藤和也, 谷洋江, 岩佐幸恵, 高橋裕子, 谷岡哲也 :
高校生を対象とした喫煙防止教育の効果及び家族への波及効果,
四国医学雑誌, Vol.68, No.3.4, 131-138, 2012年.

(要約): The aim of this survey was to clarify the effects of smoking prevention education to the highschoolstudents, and its ripple effects to their families. Participants were same group of630students.Questionnaire surveys were conducted, self-reporting and anonymous, immediately beforeand after the lecture meeting, and after8month in2011‐2012fiscal year. As a result, significantfavorable changes were observed in female students regarding the images of smoking and the predictionof behavior associated with smoking in the future. However, favorable outcome was notobserved among both male and female students after eight months. As useful educational contents,to help stop smoking behavior in the future, the causes of vulnerability to cancer and strongdependence on nicotine were pointed out. Significantly high rates were observed : male studentsselected the"economical reasons"", social responsibility"and"transition of smoking rate"; femalestudents selected the"effect on appearance"and"effect on babies". Also, the smoking rate of theparents of targeted students was lower than the national average, which revealed that their parentswere grappling with the problem of smoking abstinence, caused by the chance of having conversationsabout smoking with their family members. We conclude that it is necessary to construct theeducational contents appropriate for the characteristics of each targeted group including familybackground in order to make smoking abstinence a success. Future studies are also necessary todevelop effective educational continuous and periodical approaches of the lecture meeting, whichwill trigger the cessation of smoking and promote conversation within the family unit.
(キーワード): preventing smoking education / high-school students / effect of education / family smoking / ripple effects to their families
(徳島大学機関リポジトリ): ● Metadata: 102834
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812441546112

(徳島大学機関リポジトリ: 102834, CiNii: 1050282812441546112) Mitsuteru Yoshida, Takanori Miyoshi, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
Pemphigus with thymoma improved by thymectomy: report of a case,
Surgery Today, Vol.43, No.7, 806-808, 2012.

(要約): A 53-year-old female with pemphigus vulgaris received treatment with prednisolone for 3 years. On chest computed tomography performed at follow-up, an anterior-mediastinal tumor (4 cm × 3 cm) was detected and diagnosed as a thymoma. Although amyosthenia was absent, the patient's anti-acetylcholine-receptor antibody level was high, and she was positive for anti-desmoglein 3 antibodies. She underwent extended thymectomy in the same year, following which both the anti-acetylcholine receptor antibody and the anti-desmoglein 3 antibody levels were normalized. The patient's skin symptoms improved, and the steroid dose was gradually lowered and finally discontinued 4 years postoperatively. Extended thymectomy may be an effective therapy for treating patients with pemphigus.
(キーワード): 自己免疫 (autoimmunity) / Female / Humans / Middle Aged / Paraneoplastic Syndromes / Pemphigus / Thymectomy / Thymoma / Thymus Neoplasms / Treatment Outcome
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s00595-012-0272-z
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22855008; ● Search Scopus @ Elsevier (PMID): 22855008; ● Search Scopus @ Elsevier (DOI): 10.1007/s00595-012-0272-z

(DOI: 10.1007/s00595-012-0272-z, PubMed: 22855008) 後藤正和, 先山正二, 鳥羽博明, 監﨑孝一郎, 近藤和也, 丹黒章 :
右中下葉・瘻管切除を施行した低肺機能の成人先天性食道気管支瘻の1例,
日本臨床外科学会雑誌, Vol.73, No.5, 1075-1079, 2012年.

(キーワード): 気管食道瘻 / 合併症 / 外科的療法 / 病理学
(出版サイトへのリンク): ● Publication site (DOI): 10.3919/jjsa.73.1075
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390001204852799872; ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.73.1075

(DOI: 10.3919/jjsa.73.1075, CiNii: 1390001204852799872) 坂本晋一, 梶浦耕一郎, 滝沢宏光, 中川靖士, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 吉田光輝, 川上行奎, 田所由紀子, 先山正二, 近藤和也, 坂東良美, 岡崎弘泰, 後東久嗣, 西岡安彦, 丹黒章 :
Erlotinibでinduction therapyを行ったIIIA期非小細胞肺癌の1手術例,
四国医学雑誌, Vol.68, No.5-6, 251-256, 2012年.

(キーワード): Carcinoembryonic Antigen(血液)
(徳島大学機関リポジトリ): ● Metadata: 110365
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812441819136

(徳島大学機関リポジトリ: 110365, CiNii: 1050282812441819136) Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kajiura, Ali Hamed Khalil Abdellah, Shoji Sakiyama and Akira Tangoku :
Computed tomography lymphography by transbronchial injection of iopamidol to identify sentinel nodes in preoperative patients with non-small cell lung cancer : A pilot study,
Journal of Thoracic and Cardiovascular Surgery, Vol.144, No.1, 94-99, 2012.

(要約): The objective of the present study was to assess the safety and feasibility of computed tomography lymphography by transbronchial injection of a water-soluble extracellular computed tomography contrast agent. From April 2010 to May 2011, patients with clinical stage I non-small cell lung cancer who were candidates for lobectomy were enrolled in the present study. An ultrathin bronchoscope was inserted to the target bronchus under the guidance of virtual bronchoscopic navigation images. Computed tomography images of the chest were obtained 0.5 and 5 minutes after 2 or 3 mL of iopamidol was injected through a microcatheter. Sentinel nodes were identified when the maximum computed tomography attenuation value of the lymph nodes on the postcontrast computed tomography images increased by 30 Hounsfield units or more compared with the precontrast images. Patients underwent lobectomy with standard lymph node dissection. The ultrathin bronchoscope could access the targeted bronchus, and iopamidol was delivered into the peritumoral area in all 13 patients without any complications. Sentinel nodes were identified in 12 (92.3%) of the 13 patients. The average number of sentinel nodes was 1.5 (range, 1-2). Pathologic examination revealed metastatic lymph nodes in 2 patients. Metastatic nodes were included with the sentinel nodes. Computed tomography lymphography by transbronchial injection of iopamidol was a safe and feasible method to identify the sentinel nodes in patients with clinical stage I non-small cell lung cancer.
(キーワード): Aged / Carcinoma, Non-Small-Cell Lung / Contrast Media / Female / Humans / Injections / Iopamidol / Lung Neoplasms / Lymphography / Male / Middle Aged / Neoplasm Staging / Pilot Projects / Pneumonectomy / Sentinel Lymph Node Biopsy / Thoracic Surgery, Video-Assisted / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2012.03.040
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22507846; ● Search Scopus @ Elsevier (PMID): 22507846; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2012.03.040

(DOI: 10.1016/j.jtcvs.2012.03.040, PubMed: 22507846) 鳥羽博明, 先山正二, 森本雅美, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
摘出時にラリンジアルマスクを使用した小児気管支異物の1例,
気管支学, Vol.34, No.2, 180-183, 2012年.

(要約): 背景.摘出時にラリンジアルマスクを使用した小児気管支異物の1例を経験したので報告する.症例.1歳6カ月の女児.ピーナッツを食べた際に誤嚥.その後,喘鳴が出現し,前医に入院.抗菌薬を投与されていたが,翌日施行された胸部CTにて気管支異物を疑われ,当院に搬送された.CTにて左主気管支に異物と思われる陰影を認め,気管支異物と診断し,同日全身麻酔下に異物除去を施行した.ラリンジアルマスク(サイズ2.0)を使用して気道を確保した後,外径4.0mmの軟性気管支鏡を挿入し,バルーン付きカテーテルにて摘出した.異物はピーナッツであった.結論.小児気管支異物に対して,ラリンジアルマスクの使用により,異物摘出時の有効な換気と軟性気管支鏡のスムーズな操作性を担保することができた.
(キーワード): *異物(治療,X線診断)
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1390282679727797504

(CiNii: 1390282679727797504) Midori Yoshida, Kazuya Kondo, Chieko Nakanishi and Toshiko Tada :
Interventional study for improvement of lung cancer screening rate,
The Journal of Medical Investigation : JMI, Vol.59, No.1,2, 127-135, 2012.

(要約): The aim of this study is to evaluate whether leaflet distribution affects lung screening rate, and what factor affects the motivation of consultation. Men and women aged 40 to 59 were targeted to improve screening rate of ages for cancer screening, especially in their prime. Each 1,000 subject, a total of 2,000 were selected and divided into 8 groups in consideration of age group by random sampling method. This group was further divided into two groups, an intervention group including subjects distributed a leaflet and a non-intervention (control) group. A survey was conducted by postal self-administered survey forms. Collection rate was 21.6% for the intervention and 17.6% for the control group. The numbers of respondents who answered that this leaflet was effective for motivation of consulting lung cancer screening and the leaflet was ineffective, were 120 (60.0%) and 80 (40.0%), respectively. This indicated that the leaflet was clearly effective (p<0.01). Actual cancer screening rate was 38.8% for the intervention group and 37.7% for the control group. It was shown that distribution by mail of even a single leaflet made by National Cancer Center was effective for motivation of consultation of lung cancer screening.
(キーワード): Adult / Female / 健康増進 (health promotion) / Humans / 日本 (Japan) / Lung Neoplasms / Male / Mass Screening / Middle Aged / Motivation / Pamphlets / Questionnaires
(徳島大学機関リポジトリ): ● Metadata: 106009
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.59.127
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22450001; ● Search Scopus @ Elsevier (PMID): 22450001; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.59.127

(徳島大学機関リポジトリ: 106009, DOI: 10.2152/jmi.59.127, PubMed: 22450001) Seiji Yano, Tadaaki Yamada, Shinji Takeuchi, Keisei Tachibana, Yuko Minami, Yasushi Yatabe, Tetsuya Mitsudomi, Hidenori Tanaka, Tatsuo Kimura, Shinzoh Kudoh, Hiroshi Nokihara, Yuichiro Ohe, Jun Yokota, Hidetaka Uramoto, Kosei Yasumoto, Katsuyuki Kiura, Masahiko Higashiyama, Makoto Oda, Haruhiro Saito, Junji Yoshida, Kazuya Kondo and Masayuki Noguchi :
Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort.,
Journal of Thoracic Oncology, Vol.6, No.12, 2011-2017, 2011.

(要約): High-level HGF expression was detected more frequently than EGFR T790M secondary mutation or MET amplification in tumors with intrinsic and acquired EGFR-TKI resistance in EGFR mutant lung cancer in Japanese patients. These observations provide a rationale for targeting HGF in EGFR-TKI resistance in EGFR mutant lung cancer.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma / Drug Resistance, Neoplasm / Gene Amplification / Hepatocyte Growth Factor / Humans / Japan / Lung Neoplasms / Male / Middle Aged / Mutation / Protein Kinase Inhibitors / Proto-Oncogene Proteins c-met / Quinazolines / Receptor, Epidermal Growth Factor
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0b013e31823ab0dd
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22052230; ● Search Scopus @ Elsevier (PMID): 22052230; ● Search Scopus @ Elsevier (DOI): 10.1097/JTO.0b013e31823ab0dd

(DOI: 10.1097/JTO.0b013e31823ab0dd, PubMed: 22052230) Abdellah Hamed Khalil Ali, Hiromitsu Takizawa, Kazuya Kondo, Yasushi Nakagawa, Hiroaki Toba, Narmisheekh Khasag, Koichiro Kenzaki, Shoji Sakiyama, Hamdy Ali Mohammadien, Essam Ahmed Mokhtar and Akira Tangoku :
Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer.,
The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 46-55, 2011.

(要約): To evaluate the accuracy of fluorescence bronchoscopy by precise histological analysis of the photodynamic therapy (PDT) treated lesions.
(徳島大学機関リポジトリ): ● Metadata: 75865
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.58.46
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21372486; ● Search Scopus @ Elsevier (PMID): 21372486; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.46

(徳島大学機関リポジトリ: 75865, DOI: 10.2152/jmi.58.46, PubMed: 21372486) Khalil Abdellah Hamed Ali, Hiromitsu Takizawa, Kazuya Kondo, Hisashi Matsuoka, Hiroaki Toba, Yasushi Nakagawa, Koichiro Kenzaki, Shoji Sakiyama, Soji Kakiuchi, Yoshitaka Sekido, Saburo Sone and Akira Tangoku :
5-Aminolevulinic acid-induced fluorescence diagnosis of pleural malignant tumor.,
Lung Cancer, 2011.

(要約): BACKGROUND: It is known that endogenously synthesized protoporphyrin IX (PpIX) following the administration of 5-aminolevulinic acid (5-ALA) is an effective photosensitizer for photodynamic diagnosis (PDD). We tested in vivo and in vitro susceptibility of human lung cancer and mesothelioma cells to photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) as a photosensitizer. METHODS: Human lung cancer cell lines A549, Ma44-3, FT821 and human mesothelioma cell lines MSTO-211H, NCI-H290, Y-MESO-14 were incubated with 0.03% 5-ALA for 4h. After incubation, protoporphyrin IX (PpIX) fluorescence was detected using a fluorescence microscope. Pleural carcinosis was induced in severe combined immunodeficiency disease mice using the previous cell lines to test the efficacy of PDD in vivo. The mice were sacrificed 4h after oral administration of 400mg/kg of 5-ALA. We counted the visible tumors under white light then fluorescence light. RESULTS: In vitro, clear red fluorescence was observed in all cell lines. The mean fluorescence intensity was stronger in A549 and FT821 cells than Ma44-3 cells (165.59±26.49, 157.62±18.93 vs. 104.01±17.58). Also, MSTO-211H and NCI-H290 cells had stronger fluorescence intensity than Y-MESO-14 cells (142.51±26.85, 165.16±12.91 vs. 92.31±8.69). In vivo, the tumor detection rate of fluorescence diagnosis was 1.1-4.5 times higher than that of white light. The mean number of metastases detected by the PDD was significantly higher than that of white light for FT821 (p=0.004), Ma44-3 (p=0.006) and Y-MESO-14 cell lines (p=0.005), but not for A549, NCI-H290 and MSTO-211H cell lines. Small lesions were detected by fluorescence diagnosis even though the lesions were invisible macroscopically under white light. CONCLUSION: Our results suggest the possibility of clinical application of fluorescence diagnosis with intrapleural malignant tumors.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2011.01.031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21353719; ● Search Scopus @ Elsevier (PMID): 21353719; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2011.01.031

(DOI: 10.1016/j.lungcan.2011.01.031, PubMed: 21353719) Abdellah H. K. Ali, Kazuya Kondo, Toshiaki Namura, Yoshitaka Senba, Hiromitsu Takizawa, Yasushi Nakagawa, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure.,
Molecular Carcinogenesis, Vol.50, No.2, 89-99, 2010.

(要約): Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). In the present study, we examined epigenetic changes in chromate lung cancers. Nested-methylation-specific PCR was employed in studying the methylation of CpG islands in the APC, MGMT, hMLH1 genes in 36 chromate lung cancers and 25 nonchromate lung cancers. Methylation in chromate lung cancers was detected at 86% for APC, 20% for MGMT, and 28% for hMLH1. Whereas, it occurred at lower frequencies in nonchromate lung cancers, particularly in APC (44%) and hMLH1 (0%) genes. Our previous study showed that methylation of p16 gene in chromate lung cancer and nonchromate lung cancer was 33% and 26%, respectively. The mean methylation index (MI), a reflection of the overall methylation status, was significantly higher in chromate lung cancers than nonchromate lung cancers (0.41 vs. 0.21, P=0.001). Methylation of multiple genes (particularly hMLH1, p16, and APC genes) had experienced more than 15 yr of chromate exposure in chromate lung cancer (MI: <15 yr; 0.19, ≥ 15 yr, 0.42). There is a significant correlation of p16 and hMLH1 methylation with the expressional decrease or loss of the corresponding gene products (P=0.037 and 0.024) respectively, and an inverse correlation between APC and MGMT methylation (P = 0.014). This study provides a novel evidence for the chromium carcinogenesis that chromate lung cancer is linked to the progressive methylation of some tumor suppressor genes, which may be related to genomic instability.
(キーワード): Adaptor Proteins, Signal Transducing / Adult / Aged / Chromates / CpG Islands / DNA Methylation / DNA Modification Methylases / DNA Repair Enzymes / Epigenesis, Genetic / Genes, APC / Genes, Tumor Suppressor / Humans / Lung Neoplasms / Middle Aged / Nuclear Proteins / Occupational Diseases / Occupational Exposure / Promoter Regions, Genetic / Tumor Suppressor Proteins
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/mc.20697
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21229606; ● Search Scopus @ Elsevier (PMID): 21229606; ● Search Scopus @ Elsevier (DOI): 10.1002/mc.20697

(DOI: 10.1002/mc.20697, PubMed: 21229606) 河北直也, 鳥羽博明, 先山正二, 澤田徹, 山本洋太, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
左上下肺静脈が共通幹を形成していた肺癌の2例,
胸部外科, Vol.63, No.10, 915-918, 2010年.

(要約): A 69-year-old man and a 53-year-old man with lung cancer of left upper lobe underwent pulmonary resection. A preoperative chest computed tomography (CT) scan showed the left superior and inferior pulmonary veins forming a common trunk. In the former case, the common trunk was misidentified as the superior pulmonary vein. The latter was recognized preoperatively by using 3-dimensional CT, and successfully performed left superior segmentectomy. This variation type is surgically important because of a potential risk of intraoperative bleeding and damage to pulmonary circulation during pulmonary resection.
(キーワード): Aged / Cardiovascular Abnormalities / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Pulmonary Veins / Tomography, X-Ray Computed
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20845705; ● Search Scopus @ Elsevier (PMID): 20845705

(PubMed: 20845705) Midori Yoshida, Kazuya Kondo and Toshiko Tada :
The relation between the cancer screening rate and the cancer mortality rate in Japan,
The Journal of Medical Investigation : JMI, Vol.57, No.3,4, 251-259, 2010.

(要約): The aim of this research was to clarify the relation between the screening rates for five cancers (lung cancer, stomach cancer, colorectal cancer, uterus cancer, and breast cancer) and their mortality rate by using publicly accessible databases. The used information materials were those prepared by the Ministry of Health, Labour and Welfare, the Center for Cancer Control and Information Services, and the National Cancer Center. Our results were as follows: 1) regarding stomach and colorectal cancers, a positive correlation was found between the screening rate and the mortality rate (p<0.001); 2) in the relation between the screening rate and the mortality rate according to administrative divisions, the mortality rate decreased significantly when the lung cancer screening rate improved (p<0.005); 3) the mortality rate for breast cancer increased in those aged 50 or over; 4) the mortality rate for uterus cancer had been slightly increasing since 1990; and 5) regarding the screening rate, a positive correlation was found between breast cancer and uterus cancer (p<0.001). In future, improvement in lifestyle and in the knowledge of cancer should be promoted to enhance the screening rates.
(キーワード): Adult / Aged / Breast Neoplasms / Colorectal Neoplasms / Female / Humans / 日本 (Japan) / Lung Neoplasms / Male / Mass Screening / Middle Aged / Neoplasms / Stomach Neoplasms / Uterine Neoplasms / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 70471
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.57.251
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847525; ● Search Scopus @ Elsevier (PMID): 20847525; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.251

(徳島大学機関リポジトリ: 70471, DOI: 10.2152/jmi.57.251, PubMed: 20847525) Takanori Kanematsu, Masaki Hanibuchi, Hideki Tomimoto, Shoji Sakiyama, Koichiro Kenzaki, Kazuya Kondo, Bando Hiroyasu, Haku Takashi, Yoneda Kazuo, Hirose Toshiyuki, Toyoda Yuko, Hisatsugu Goto, Sakaguchi Satoshi, Katsuhiro Kinoshita, Momoyo Azuma, Kakiuchi Soji, Jun Kishi, Masahiko Azuma, Tada Hiroya, Sumitomo Masayuki, Yasuhiko Nishioka, Seiji Yano and Saburo Sone :
Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan,
The Journal of Medical Investigation : JMI, Vol.57, No.3,4, 326-333, 2010.

(要約): Lung cancer is the leading cause of malignancy-related death worldwide. In the present study, we reviewed the epidemiologic and clinical features of lung cancer in Tokushima Prefecture, Japan. Between January 1999 and December 2009, 2,183 patients with lung cancer were enrolled in this study. One thousand five hundred ninety-one (73%) patients were male and 592 (27%) patients were female. Median age was 70 years, with a range of 15-93 years. Seventy-six percent of patients had smoking history. One thousand nine hundred five (87%) patients were non-small cell lung cancer and the predominant histological type was adenocarcinoma (51%). Among all 2,183 patients, 702 (32%) belonged to elderly population. Four hundred seventy-one (22%), 213 (10%), 24 (1%), 116 (5%), 238 (11%), 370 (17%) and 678 (31%) patients had stage IA, IB, IIA, IIB, IIIA, IIIB and IV lung cancer, respectively. In Tokushima University Hospital, 516 (29%), 191 (11%), 58 (3%), 755 (43%) and 216 (12%) patients were initially treated with chemotherapy, chemo-radiotherapy, thoracic radiotherapy, operation and best supportive care, respectively. The median time to progression (TTP) and the median survival time (MST) of patients treated with chemotherapy and chemo-radiotherapy were 3.5 months, 13.0 months and 7.0 months, 18.0 months, respectively. The median TTP and the MST of 33 elderly patients treated with chemotherapy were 3.3 months and 18.0 months, respectively, which were comparable with those of total population. These results indicated the benefit of chemotherapy in elderly patients with advanced lung cancer by proper selection.
(キーワード): Adolescent / Adult / Age Factors / Aged / Aged, 80 and over / Carcinoma, Non-Small-Cell Lung / Carcinoma, Small Cell / Female / Humans / Japan / Kaplan-Meier Estimate / Lung Neoplasms / Male / Middle Aged / Risk Factors / 喫煙 (smoking) / Young Adult
(徳島大学機関リポジトリ): ● Metadata: 79184
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.57.326
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847534; ● Summary page in Scopus @ Elsevier: 2-s2.0-78649676894

(徳島大学機関リポジトリ: 79184, DOI: 10.2152/jmi.57.326, PubMed: 20847534, Elsevier: Scopus) Hiroaki Toba, Kazuya Kondo, Hideki Otsuka, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Diagnosis of the presence of lymph node metastasis and decision of operative indication using fluorodeoxyglucose-positron emission tomography and computed tomography in patients with primary lung cancer.,
The Journal of Medical Investigation : JMI, Vol.57, No.3-4, 305-313, 2010.

(要約): PET/CT is superior to CT scan in lymph node staging. However, because the false-positive rate is high in PET-positive lymph nodes measuring less than 1 cm in diameter, we think that clinical background should be considered and other modalities or histological examinations should be undertaken if necessary. J. Med. Invest. 57: 305-313, August, 2010.
(キーワード): Aged / Diagnostic Errors / Female / Fluorodeoxyglucose F18 / Humans / Lung Neoplasms / Lymph Node Excision / Lymphatic Metastasis / Male / Middle Aged / Neoplasm Staging / Positron-Emission Tomography / Radiopharmaceuticals / Retrospective Studies / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 73983
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.57.305
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847531; ● Search Scopus @ Elsevier (PMID): 20847531; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.305

(徳島大学機関リポジトリ: 73983, DOI: 10.2152/jmi.57.305, PubMed: 20847531) 監﨑孝一郎, 先山正二, 富本英樹, 鳥羽博明, 中川靖士, 滝沢宏光, 近藤和也, 曽根三郎, 丹黒章 :
胸部外科の指針高齢者原発性肺癌における臨床的検討,
胸部外科, Vol.63, No.7, 519-526, 2010年.

(要約): We clinically reviewed 33 surgery patients and 15 non-surgery patients aged 80 years or older with primary lung cancer treated at our hospital. The surgery group consisted of 21 males and 12 females (82.0 +/- 1.9 years old). The surgical procedures were 1 pneumonectomy, 19 lobectomies (1 bronchoplasty), 4 segmentectomies and 9 partial resections. The cancer types were 17 adenocarcinomas, 14 squamous cell carcinomas and 2 others. The stagings were 24 in stage I, 4 in stage II and 5 in stage III. There were no direct surgical deaths within 30 days post operatively. There have been 9 other disease-related deaths to date (27%). The non-surgery group consisted of 9 males and 6 females (81.7 +/- 1.5 years old). Treatment procedures consisted of radiationtherapy in 11, chemotherapy in 2 and best supportive care in 3. The cancer types were 2 adenocarcinomas, 11 squamous cell carcinomas and 2 others. The stagings were 7 in stage I, 4 in stage II and 4 in stage III. There have been 3 other disease-related deaths to date (20%). We must carefully select the therapeutic approach for elderly lung cancer patients, because the other disease-related death rates of both groups were high. The 5-year survival rate of stage I patients in the surgical group was relatively good (60.2%). There were long-term survival (7 5-year survivors) in the surgical group. Since there were some cases of radiation pneumonia in the group receiving radiation therapy, it would be better to perform surgery for elderly patients with lung cancer, especially those with stage I disease. For elderly patients, it is important to consider quality of life as well as the survival rate.
(キーワード): Age Factors / Aged / Aged, 80 and over / Female / Humans / Lung Neoplasms / Male / Pneumonectomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20662228; ● Summary page in Scopus @ Elsevier: 2-s2.0-77956070239

(PubMed: 20662228, Elsevier: Scopus) Naoko Matsui, Shunya Nakane, Fumi Saitou, Izumi Ohigashi, Yasushi Nakagawa, Hirotsugu Kurobe, Hiromitsu Takizawa, Takao Mitsui, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama and Ryuji Kaji :
Undiminished regulatory T cells in the thymus of myathenia gravis patients,
Neurology, Vol.74, No.10, 816-820, 2010.

(要約): The thymus has been implicated as a possible site of origin that triggers autoimmunity in myasthenia gravis (MG). Although several groups have suggested that the decrease in the number of regulatory T (Treg) cells contributes to the onset of MG, the exact role of Treg cells in MG remains unclear. To address this point, we examined the number and distribution of Treg cells in a large number of patients with MG. Immunohistofluorescence analysis of Foxp3 along with CD4 and CD8 was performed in thymic sections of MG (+) (n = 24) and MG (-) patients (n = 27). Circulating CD4(+)CD25(+) cells in the peripheral blood of patients with MG (n = 15) and age-matched healthy subjects (n = 15) were also analyzed. Foxp3(+)CD4(+)CD8(-) cells were predominantly found in the thymic medulla and their number declined with age. There was no significant difference in the number or the distribution of Foxp3(+)CD4(+)CD8(-) cells in the thymus between MG (+) and MG (-) patients. The number of circulating CD4(+)CD25(+) cells in the peripheral blood of patients with MG was not significantly altered compared to that in healthy subjects. The cellularity of Treg cells in the thymus and circulation is not diminished in patients with myasthenia gravis.
(キーワード): Age Factors / Antigens, CD / Cell Count / Female / Flow Cytometry / Forkhead Transcription Factors / Humans / Male / Myasthenia Gravis / T-Lymphocytes, Regulatory / Thymus Gland
(出版サイトへのリンク): ● Publication site (DOI): 10.1212/WNL.0b013e3181d31e47
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20211905; ● Search Scopus @ Elsevier (PMID): 20211905; ● Search Scopus @ Elsevier (DOI): 10.1212/WNL.0b013e3181d31e47

(DOI: 10.1212/WNL.0b013e3181d31e47, PubMed: 20211905) 河北直也, 滝沢宏光, 鳥羽博明, 監﨑孝一郎, 先山正二, 近藤和也 :
Gefitinib耐性後に切除した肺腺癌術後肺転移の1例,
日本呼吸器外科学会雑誌, Vol.24, No.2, 42-45, 2010年.

(出版サイトへのリンク): ● Publication site (DOI): 10.2995/jacsurg.24.166
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.24.166

(DOI: 10.2995/jacsurg.24.166) Hiroaki Toba, Kazuya Kondo, Koichiro Kenzaki, Takanori Miyoshi, Shoji Sakiyama and Akira Tangoku :
Late pulmonary metastases from malignant melanoma of the left planta.,
General Thoracic and Cardiovascular Surgery, Vol.57, No.10, 558-561, 2009.

(要約): We report a patient treated for malignant melanoma of the left planta who developed pulmonary metastases after a disease-free interval of 10 years. Metastatectomy was performed after observing progress for 12 months. However, 18 months later, pretracheal and right axillary lymph node metastases occurred. Because pulmonary metastasis from malignant melanoma may occur after 10 years or more, we observe patients carefully. If it does occur, an operation should be considered under limited indications. We should also recognize that recurrence may occur within a short interval after metastatectomy as well.
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11748-009-0438-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19830522; ● Search Scopus @ Elsevier (PMID): 19830522; ● Search Scopus @ Elsevier (DOI): 10.1007/s11748-009-0438-9

(DOI: 10.1007/s11748-009-0438-9, PubMed: 19830522) Naoko Matsui, S Nakane, Y Nakagawa, Kazuya Kondo, T Mitsui, T Matsumoto, Kokichi Arisawa and Ryuji Kaji :
Increasing incidence of elderly onset patients with myasthenia gravis in a local area of Japan,
Journal of Neurology, Neurosurgery, and Psychiatry, Vol.80, No.10, 1168-1171, 2009.

(要約): As the number of elderly patients with myasthenia gravis (MG) has recently increased in Europe and the USA, a retrospective survey of Japanese MG patients was conducted in a single neurological centre over several decades. The study consisted of 112 consecutive MG patients with onset of the disease from 1971 to 2006 from an area of approximately 0.8 million inhabitants in Japan. Patients were classified into three subgroups according to age at onset: young onset (39 years old), middle aged onset (40-59 years old) and elderly onset (60 years old). The trends in incidence rate and clinical features were examined: disease severity, seropositivity for antiacetylcholine receptor antibody, occurrence of other autoimmune diseases, occurrence of thymoma and therapeutic response. The onset adjusted age specific average annual incidence per 100,000 of the elderly onset MG patients increased 20-fold from 1981-1990 (0.06; 95% CI 0.00 to 0.36) to 2001-2006 (1.30; 95% CI 0.77 to 2.05). Clinical features of the elderly onset MG patients included low antiacetylcholine receptor antibody titres (mean 24.6 nmol/l), less frequent autoimmune overlaps (8.0%) and nearly no complete stable remission with or without thymectomy. The increasing incidence of elderly onset MG in Japanese patients similar to that reported in Caucasians has been confirmed. The clinical features suggest different immunological backgrounds between young onset and elderly onset MG patients, irrespective of the ethnic background.
(キーワード): Adult / Age Distribution / Age of Onset / Aged / Asian Continental Ancestry Group / Catchment Area (Health) / Cohort Studies / Female / Hospitals, University / Humans / Incidence / 日本 (Japan) / Male / Middle Aged / Myasthenia Gravis / Retrospective Studies / Sex Distribution
(出版サイトへのリンク): ● Publication site (DOI): 10.1136/jnnp.2008.152637
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19762910; ● Search Scopus @ Elsevier (PMID): 19762910; ● Search Scopus @ Elsevier (DOI): 10.1136/jnnp.2008.152637

(DOI: 10.1136/jnnp.2008.152637, PubMed: 19762910) Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Fluorescence diagnosis of lymph node metastasis of lung cancer in a mouse model.,
Oncology Reports, Vol.22, No.1, 17-21, 2009.

(要約): Fluorescence diagnosis of lymph node metastasis of non-small cell lung cancer has not been reported previously. This study was conducted to evaluate the feasibility of fluorescence detection using 5-aminolevulinic acid and mono-L-aspartyl chlorine e6 for lymph node metastasis in a lung cancer mouse model. Human lung cancer cell line Ma44-3, which forms metastatic lymph nodes in the mediastinum, was injected into the left lungs of 6 severe combined immunodeficiency disease mice. Two weeks after implantation, 2 groups of 3 mice received oral administration of 5-aminolevulinic acid (100 mg/kg) or intraperitoneal administration of mono-L-aspartyl chlorine e6 (5 mg/kg). Both lungs and mediastinal organs were removed en-bloc and illuminated with blue light (405 nm) to evaluate the detectability of lung tumors and metastatic lymph nodes in the mediastinum. These organs were evaluated histopathologically. Clear red fluorescence was observed in the lung tumors of all mice. Metastatic lymph nodes had formed in 5 of 6 mice and were detected by fluorescent detection in all 5 mice even though one of the lymph nodes was invisible macroscopically under white light. In conclusion, fluorescence diagnosis of lymph node metastasis is possible in a mouse model. The successful result with small lymph node metastasis suggests the possibility of clinical application.
(出版サイトへのリンク): ● Publication site (DOI): 10.3892/or_00000400
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19513499; ● Search Scopus @ Elsevier (PMID): 19513499; ● Search Scopus @ Elsevier (DOI): 10.3892/or_00000400

(DOI: 10.3892/or_00000400, PubMed: 19513499) M Yoshida, Shoji Sakiyama, Koichiro Kenzaki, Hiroaki Toba, K Uyama, M Takehisa, Kazuya Kondo and Akira Tangoku :
Functional evaluation of pallid mice with genetic emphysema.,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.89, No.7, 760-768, 2009.

(要約): Studies on pallid mice models of genetic emphysema have conventionally focused on morphological or biochemical evaluations. However, it is important to consider the functional aspects. We evaluated the exercise capacity and respiratory function in male pallid mice and male C57BL/6J mice at 3, 6, 12, and 15 months of age. The functional evaluations were conducted using a treadmill and a pulmonary function analysis device. The morphology of the lungs was analyzed on the basis of mean linear intercept (Lm) values. The body weights of the pallid mice at 12 and 15 months were significantly lower than those of the age-matched C57BL/6J mice. The pallid mice showed deterioration in exercise capacity from 6 months, as indicated by the trends in running distance. At 6, 12, and 15 months, the pallid mice showed significantly higher pulmonary compliance and significantly lower forced expiratory volume in 20 ms (FEV(20 ms))/vital capacity (VC) values in comparison with the corresponding values for the C57BL/6J mice. In the morphological analysis of the pallid mice, emphysema was detected from 12 months, and the mice showed a significantly larger Lm at 12 months. The exercise capacity and lung function in the pallid mice significantly deteriorated from 6 months, at which time no pathological changes in the lung were detected. The deterioration in the exercise capacity and pulmonary function preceded the microscopic morphological changes.Laboratory Investigation advance online publication, 20 April 2009; doi:10.1038/labinvest.2009.34.
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/labinvest.2009.34
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19381131; ● Search Scopus @ Elsevier (PMID): 19381131; ● Search Scopus @ Elsevier (DOI): 10.1038/labinvest.2009.34

(DOI: 10.1038/labinvest.2009.34, PubMed: 19381131) Hiromichi Yamai, Naruhiko Sawada, Takahiro Yoshida, Junnichi Seike, Hiromitsu Takizawa, Koichiro Kenzaki, Takanori Miyoshi, Kazuya Kondo, Yoshimi Bando, Yoshinari Ohnishi and Akira Tangoku :
Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo.,
International Journal of Cancer, Vol.125, No.4, 952-960, 2009.

(要約): The antineoplastic effects of combinations of anticancer drugs (5-fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by the WST-8 (2-(2-methoxy- 4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) assay in vitro and by an animal model in vivo. Triterpenes and JAE showed additive and synergistic cytotoxic effects, respectively, on esophageal squamous carcinoma cells (YES-2cells) by combinational use of 5-fluorouracil. JAE and 5-fluorouracil induced cell cycle arrest at G2/M phase and at S phase, respectively, and caused apoptosis in YES-2 cells. A new animal model of esophageal cancer causing tumor colonization of the peritoneal cavity and producing bloody ascites was made by injecting YES-2 cells into the peritoneal cavity of a severe combined immunodeficiency mouse. In this model, 5-fluorouracil inhibited colonization of tumor cells in the peritoneum. The addition of JAE to 5-fluorouracil augmented the suppression of experimental metastasis of the peritoneum. The numbers of peritoneal nodules of more than 2 mm in diameter in mice treated with 5-fluorouracil and JAE were less than those in mice treated with 5-fluorouracil alone or JAE alone. These results suggest that triterpenes, especially JAE, are effective supplements for enhancing the chemotherapeutic effect of 5-fluorouracil on esophageal cancer. (c) 2009 UICC.
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/ijc.24433
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19462449; ● Search Scopus @ Elsevier (PMID): 19462449; ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.24433

(DOI: 10.1002/ijc.24433, PubMed: 19462449) Hiroaki Toba, Kazuya Kondo, Hiromitsu Takizawa and Akira Tangoku :
Recurrent thymoma with a pleural dissemination invading the intervertebral foramen.,
European Journal of Cardio-Thoracic Surgery, Vol.35, No.5, 917-919, 2009.

(要約): We report a rare case of recurrent thymoma with pleural dissemination invading the intervertebral foramen. A woman with Masaoka's stage IVa thymoma with myasthenia gravis (MG) underwent macroscopically complete resection. After 45 months, she developed back pain. Computed tomography (CT) of the chest demonstrated a mass in the right thoracic cavity invading the intervertebral foramen between thoracic vertebrae 10 and 11. She underwent complete resection of the tumor and postoperative radiotherapy. The resected specimen was histologically diagnosed as a pleural dissemination from thymoma. There has been no local recurrence.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.ejcts.2009.01.036
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19269845; ● Search Scopus @ Elsevier (PMID): 19269845; ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejcts.2009.01.036

(DOI: 10.1016/j.ejcts.2009.01.036, PubMed: 19269845) 鳥羽博明, 先山正二, 森本雅美, 滝沢宏光, 監﨑孝一郎, 近藤和也, 坂東良美, 丹黒章 :
肺多形癌の3切除例,
胸部外科, Vol.62, No.3, 202-206, 2009年.

(要約): We experienced 3 resected cases of pleomorphic carcinoma of the lung. Each cases were 74-year-old man (case 1), 74-year-old woman (case 2) and 69-year-old man (case 3). Two patients (case 1 and 2) were histologically diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with giant cell carcinoma. One patient (case 3) was similarly diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with adenocarcinoma and squamous cell carcinoma. Although lymph nodes metastasis were not recognized in all patients, invasion to vessels were recognized in 2 patients (case 1 and 3). In one patient (case 1), recurrence was recognized at contralateral side 1 month after surgery and he died of other disease 2 months after surgery. The other 2 patients were alive without recurrence 24 and 5 months after surgery. Recently it is reported that recurrence is recognized at early phase after surgery and prognosis is poor in a case with vessel invasions in spite of pathological NO state. Since one patient (case 3) had nonmetastatic lymph nodes with vessel invasions, careful observation is considered to be necessary.
(キーワード): Aged / Aged, 80 and over / Carcinoma / Diagnostic Imaging / Fatal Outcome / Female / Humans / Lung Neoplasms / Male / Neoplasm Staging / Treatment Outcome
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19280950; ● Search Scopus @ Elsevier (PMID): 19280950

(PubMed: 19280950) 監﨑孝一郎, 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
気管・気管支形成手術の現況 2．気管・気管支形成原発性肺癌における気管・気管支形成手術の臨床的検討,
胸部外科, Vol.61, No.11, 951-956, 2008年.

(要約): In our department, there were 482 thoracic surgeries for primary lung cancer between 1994 and 2007. We clinically reviewed cases that underwent tracheoplasty or bronchoplasty (n = 22, 4.6%). The patients consisted of 21 males and 1 female (66.5 +/- 12.0 years-old). All patients were smokers. The tissue forms were 19 squamous cell carcinomas, 2 adenocarcinomas, 1 large cell carcinoma, 1 adenoid cystic carcinoma and 1 carcinoid, including 2 multiple carcinomas. Sleeve resections involved the trachea in 1, upper lobes in 13, lower lobes in 3, upper-middle lobes in 2 and intermediate bronchus in 1. Wedge resections were performed in the upper lobes in 2. Fourteen reconstructions were performed. We ordinarily sutured the trachea and bronchus in any case, using a single outside knot. There was no leakage at the anastomosis. There were 2 hospital deaths. There were 4 cancer deaths, including 2 local recurrences. There were 4 patients demonstrating stenosis post operatively. There were 3 stenoses among 4 preoperative radiation therapies. We considered that radiation therapy disturbed the repair of the anastomosis. There were 8 pneumonia patients who developed post operatively. There were 2 operative hospital deaths among 3 angio-bronchoplasties without coverage. Recently, we have routinely covered the anastomosis at the reconstruction site and have not experienced any major complications.
(キーワード): Aged / Bronchi / Female / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Prognosis / Radiotherapy, Adjuvant / Reconstructive Surgical Procedures / Thoracic Surgical Procedures / Trachea
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18939431; ● Search Scopus @ Elsevier (PMID): 18939431

(PubMed: 18939431) Yukiko Hirose, Kazuya Kondo, Hiromitsu Takizawa, Taeko Nagao, Yasushi Nakagawa, Haruhiko Fujino, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Aberrant methylation of tumour-related genes in thymic epithelial tumours.,
Lung Cancer, Vol.64, No.2, 155-159, 2008.

(要約): BACKGROUND: Thymoma is an uncommon neoplasm derived from epithelial cells of the thymus. Few studies have addressed the genetic alterations that occur in the tumourigenesis of thymoma. METHODS: We examined aberrant DNA methylation of DAP-K, p-16, MGMT and HPP1 genes in 26 thymomas and 6 thymic carcinoma to clarify the association between aberrant DNA methylation and clinicopathological features. RESULTS: Fifteen (47%) of 32 thymic epithelial tumours showed aberrant methylation. Aberrant methylation was more frequent in thymic carcinoma (86%) than in thymoma (29%). Moreover, the frequency of tumours with methylation of multiple genes in thymic carcinoma was higher than in thymoma (60% vs 20%). In thymoma, the frequency of tumour methylation, including the type A tumour component (28%), was lower than that of tumours with type B tumour component (42%). MGMT methylation was detected in 23% of thymoma and in 83% of thymic carcinoma. The frequency of methylation of the MGMT gene in both tumours was high compared with the other 3 genes. CONCLUSIONS: Aberrant DNA methylation was more frequent in thymic carcinoma than in thymoma, and the frequency of DNA methylation in thymic epithelial tumours is roughly parallel to their malignant behaviour.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2008.07.015
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18778870; ● Search Scopus @ Elsevier (PMID): 18778870; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2008.07.015

(DOI: 10.1016/j.lungcan.2008.07.015, PubMed: 18778870) 吉田光輝, 先山正二, 監﨑孝一郎, 鳥羽博明, 近藤和也, 丹黒章 :
手術の工夫両側転移性肺腫瘍に対するclamshell incisionによるアプローチ,
胸部外科, Vol.61, No.3, 206-209, 2008年.

(要約): In recent years thoracotomy by "clamshell incision" has frequently been chosen for heart-lung transplantation, bilateral lung tumors and mediastinal tumor merging into lung tumor because this approach provides very good visibility to access the whole bilateral lung including the lower lobe and mediastinal organs. In our hospital, 4 patients underwent bilateral thoracotomy by clamshell incision for pulmonary metastasectomy between 2001 and 2005. All cases had bilateral pulmonary metastases, and multiple wedge resection was performed. All lesions that were planned for resection on preoperative computed tomography (CT) could be resected. Regarding the surgical approach to bilateral pulmonary metastases that did not need lobectomy, clamshell incision is one of the useful approaches that can allow wedge resection anywhere in the whole lung. In cases that are expected multiple procedures, bilateral thoracotomy by clamshell incision is recommended because it allows another route for thoracotomy at reoperation.
(キーワード): Adult / Aged / Female / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy / Sternum / Thoracotomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18323186; ● Search Scopus @ Elsevier (PMID): 18323186

(PubMed: 18323186) 鳥羽博明, 近藤和也, 吉田光輝, 監﨑孝一郎, 三好孝典, 先山正二, 丹黒章 :
縦隔悪性リンパ腫の臨床的検討,
胸部外科, Vol.61, No.2, 97-101, 2008年.

(要約): Sixteen cases of mediastinal lymphoma in our hospital were reviewed clinically. There were 7 men and 9 women, whose mean age is 35 years old. The histological types were non-Hodgkins' disease in 12 (B-cell type in 6 and T-cell type in 6), Hodgkins' disease in 2, mucosa-associated lymphoid tissue (MALT) lymphoma in 2. All cases except 1 in which percutaneous needle biopsy was performed were diagnosed histologically. Even small specimens by percutaneous needle biopsy can be helpful in diagnosing histological type and subtype with immunohistlogy, recommending percutaneous needle biopsy as an mitial step for diagnosis. When histological diagnosis can not be made by needle biopsy, open biopsy should be done.
(キーワード): Adolescent / Adult / Aged / Child / Combined Modality Therapy / Diagnosis, Differential / Female / Hodgkin Disease / Humans / Lymphoma, B-Cell / Lymphoma, B-Cell, Marginal Zone / Lymphoma, T-Cell / Male / Mediastinal Neoplasms / Middle Aged / Salvage Therapy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18268943; ● Search Scopus @ Elsevier (PMID): 18268943

(PubMed: 18268943) Hiromitsu Takizawa, Kazuya Kondo, Hisashi Matsuoka, Koh Uyama, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama, Akira Tangoku, Kazumasa Miura, Kiyoshi Yoshizawa and Junji Morita :
Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer,
The Journal of Medical Investigation : JMI, Vol.55, No.1,2, 37-43, 2008.

(要約): Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58: sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 +/- 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 +/- 7.0 (p < 0.001). Postoperatively N2 disease was detected in 8 patients (13.8%) in the dissection group and 7 (11.5%) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% in the dissection group and 76.2% in the sampling group (p = 0.60). Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma, Small Cell / Female / Follow-Up Studies / Humans / Lung Neoplasms / Lymph Node Excision / Lymph Nodes / Lymphatic Metastasis / Male / Mediastinum / Middle Aged / Neoplasm Staging / Pneumonectomy / Prognosis / Retrospective Studies / Survival Rate
(徳島大学機関リポジトリ): ● Metadata: 110836
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.55.37
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18319543; ● Search Scopus @ Elsevier (PMID): 18319543; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.37

(徳島大学機関リポジトリ: 110836, DOI: 10.2152/jmi.55.37, PubMed: 18319543) Kazuya Kondo :
Optimal therapy for thymoma,
The Journal of Medical Investigation : JMI, Vol.55, No.1, 2, 17-28, 2008.

(要約): Thymoma is the most common tumor of the anterior mediastinum. This tumor is associated with unique paraneoplastic syndromes (myasthenia gravis, pure red cell aplasia, hypogammaglobulinemia, and other autoimmune diseases). The rarity of this tumor has somewhat obscured the optimal treatment. Although the histologic classification of thymoma has remained a subject of controversy for many years, the WHO classification system, published in 1999, appeared to be an advance in our understanding of thymoma. The optimal treatment for thymoma depends on its clinical stage. Surgery remains the mainstay of treatment for thymic epithelial tumors. Thymomas also have a high response rate to chemotherapy or radiotherapy. Only surgical resection is performed for patients with stage I (non-invasive) thymoma. The value of postoperative radiotherapy in completely resected stage II or III tumors is questionable. Multimodality therapy involving surgery, chemotherapy and radiotherapy appears to increase the rate of complete resection and survival in advanced (stage III and IV) thymomas.
(キーワード): Antineoplastic Agents / Chemotherapy, Adjuvant / Cisplatin / Combined Modality Therapy / Humans / Neoplasm Staging / Prognosis / Radiotherapy Dosage / Radiotherapy, Adjuvant / Thymectomy / Thymoma / Thymus Neoplasms / World Health Organization
(徳島大学機関リポジトリ): ● Metadata: 110834
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.55.17
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18319541; ● Search Scopus @ Elsevier (PMID): 18319541; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.17

(徳島大学機関リポジトリ: 110834, DOI: 10.2152/jmi.55.17, PubMed: 18319541) Kazuhide Yoneda, Junji Ueno, Sadamitsu Nishihara, Tetsuya Tsujikawa, Naomi Morita, Hideki Otsuka, Kaori Furutani, Hiromu Nishitani, Kazuya Kondo and Yasuhiko Nishioka :
Postprocessing technique with MDCT data improves the accuracy of the detection of lung nodules,
Radiation Medicine, Vol.25, No.10, 511-515, 2007.

(要約): The aim of this study was to determine whether postprocessing techniques could improve the accuracy of detecting lung nodules. A total of 154 segmented lung volumes of multidetector-row computed tomography (MDCT) data were the subject of the study. Lung nodules were present in 88 volumes and absent in 66 volumes. We prepared four groups: (1) 7- or 10-mm thick-section axial images; (2) 1-mm thin-section axial images; (3) sliding slab maximum intensity projection (MIP) images with a slab thickness of 15 mm; and (4) sliding slab volume rendering (VR) images with a slab thickness of 15 mm. Sixteen physicians reviewed each group in interactive cine mode. The observers' performance in the detection of lung nodule was evaluated by receiver operating characteristic (ROC) analysis. The observers' performance of the MIP and VR groups was significantly better than in other two groups. There was no significant difference statistically between the thin and thick groups. The detectability of lung nodules is improved with the use of sliding slab MIP and VR using thin-section image data. Thin-section volume data are essential for improving diagnostic accuracy, but observation of thin-section images without utilization of image-processing techniques dose not improve diagnostic accuracy.
(キーワード): MD CT / Lung nodule / Sliding slab / MIP / VR / Thin-section image
(出版サイトへのリンク): ● Publication site (DOI): 10.1007/s11604-007-0176-9
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18085401; ● Summary page in Scopus @ Elsevier: 2-s2.0-40349087195

(DOI: 10.1007/s11604-007-0176-9, PubMed: 18085401, Elsevier: Scopus) Kazuya Kondo, Takanori Miyoshi, Haruhiko Fujino, Hiromitsu Takizawa, Satoshi Imai, Naoki Kobayashi, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Photodynamic therapy using a second generation photosensitizer, Talaporfin,
Photodiagnosis and Photodynamic Therapy, Vol.4, No.4, 269-274, 2007.

(要約): Background: Photodynamic therapy (PDT) using Talaporfin is an attractive treatment for centraltype early lung cancer. It was noted that some patients had altered levels of arterial oxygen saturation as indicated by pulse oximeter (SpO2) and arterial oxygen saturation levels in blood gas analysis (SaO2) during PDT. The present experiments were designed to provide an explanation for these findings. Methods: The influence of Talaporfin on SpO2 using in vitro and in vivo experiments, and clinically, was examined. Results: Our in vitro and in vivo experiments showed a linear relationship between Talaporfin concentration in the plasma and the SpO2 level (R = 0.9957 and 0.9837). The apparent SpO2 level decreased according to the increase of Talaporfin concentration in the plasma. In two patients with PDT, SpO2 levels at 4 6 h and 24 h after Talaporfin administration were 93% and 97%, respectively. Conclusions: Talaporfin raised blood absorbance at 660nm with a pulse oximeter. It appeared that the presence of the drug falsely decreased the level of SpO2 since SpO2 did not actually change.
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.pdpdt.2007.06.001
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.1016/j.pdpdt.2007.06.001

(DOI: 10.1016/j.pdpdt.2007.06.001) Mitsuteru Yoshida, Kazuya Kondo, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Two cases of bronchogenic cyst with severe adhesion to the trachea,
The Journal of Medical Investigation : JMI, Vol.54, No.1-2, 187-190, 2007.

(要約): We experienced two bronchogenic cysts with severe adhesion to the trachea. Both cysts were located on the right side of the trachea. The surgical procedure was changed to thoracotomy from thoracoscopic surgery due to strong adhesion to the trachea. In case 1, sharp separation of the cystic wall from the trachea led to tracheal wall damage. In case 2, the cystic wall except a portion which was adhered to the trachea was resected. The inner side of the residual cystic wall underwent dull curettage to remove the epithelial component. There were no postoperative complications in either case.
(キーワード): Adult / Bronchogenic Cyst / Female / Humans / Thoracotomy / Tissue Adhesions / Tracheal Diseases
(徳島大学機関リポジトリ): ● Metadata: 111512
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.54.187
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17380032; ● Search Scopus @ Elsevier (PMID): 17380032; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.187

(徳島大学機関リポジトリ: 111512, DOI: 10.2152/jmi.54.187, PubMed: 17380032) Takanori Miyoshi, Kazuya Kondo, Hiroaki Toba, Mitsuteru Yoshida, Haruhiko Fujino, Koichiro Kenzaki, Shoji Sakiyama, Masatsugu Takehisa and Akira Tangoku :
Predictive Value of Thymidylate Synthase and Dihydropyrimidine Dehydrogenase Expression in Tumor Tissue, Regarding the Efficacy of Postoperatively Administered UFT(Tegafur+Uracil) in Patients with Non-small Cell Lung Cancer,
Anticancer Research, Vol.27, No.4C, 2641-2648, 2007.

(要約): UFT (tegafur + uracil) has been reported to be effective as an adjuvant in postoperative chemotherapy for non-small cell lung cancer (NSCLC) in a randomized prospective study. Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression were investigated in resected tumors and the relationship between their expression and clinical factors in NSCLC patients was examined. Fifty-four NSCLC patients had undergone complete surgical resection and lymph node dissection, and had been administered UFT post-surgery. The TS and DPD expression in the tumor tissues was evaluated by immunohistochemical staining. The relationship between TS and/or DPD expression and clinicopathological factors was examined. There were 38 TS-negative and 16 TS-positive cases, and 22 DPD-negative and 32 DPD-positive cases. There was no significant difference between the patients with TS or DPD and those without TS or DPD in age, gender, histological type or p-stage. The 5-year survival rates of patients positive and negative for TS were 50.0 and 89.5%, while 10-year survival rates were 23.3 and 79.7%, respectively (p<0.001). The 5-year survival rates of TS-positive and TS-negative patients in p-stage I were 54.6 and 95.5%, while 10-year survival rates were 22.7 and 95.5%, respectively (p<0.001). There was no significant difference between DPD-positive and DPD-negative patients in prognosis. The oral administration of UFT after surgery might improve the survival of NSCLC patients when TS levels in tumor tissues are low. Immunohistochemical evaluation of TS and DPD expression may be useful for predicting the efficacy of UFT after complete resection in NSCLC.
(キーワード): Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Non-Small-Cell Lung / Dihydrouracil Dehydrogenase (NADP) / Female / Humans / Immunohistochemistry / Lung Neoplasms / Lymph Node Excision / Male / Middle Aged / Neoplasm Staging / Tegafur / Thymidylate Synthase / Uracil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17695427; ● Search Scopus @ Elsevier (PMID): 17695427

(PubMed: 17695427) Kazuya Kondo, Yuji Takahashi, Yukiko Hirose, Taeko Nagao, Masaru Tsuyuguchi, Masato Hashimoto, Atsushi Ochiai, Yasumasa Monden and Akira Tangoku :
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.,
Lung Cancer, Vol.53, No.3, 295-302, 2006.

(要約): STUDY OBJECTIVES: It is known that chromium is one of the important inhaled carcinogens that cause lung cancer. Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). However, the epigenetic effects of chromium are not understood. MATERIALS AND METHODS: We investigated the methylation of the p16 gene using a methylation-specific PCR method in 30 chromate lung cancers and 38 non-chromate lung cancers, and the expression of the p16 protein using immunohistochemistry in 25 chromate lung cancers. RESULTS: Ten (33%) chromate lung cancers showed methylation of the p16 promoter region. On the other hand, 10 (26%) of the non-chromate lung cancers also showed it. The frequency of p16 methylation in non-chromate lung cancer was 0%, 33% and 30% for low (< or =600), moderate (<600, >1000) and high (> or =1000) Brinkman indexes, respectively. However, the frequency of p16 methylation in chromate lung cancer was constant, irrespective of the Brinkman index. In chromate lung cancer, patients with chromate exposure of less than 15 years never had p16 methylation, while 40% (> or =25 years) or 43% (> or =15, <25 years) of patients with chromate exposure of more than 15 years did. In chromate lung cancer, chromate exposure, not smoking, mainly influenced the p16 methylation. Most of the chromate lung cancers with p16 methylation (85.7%) showed repression of the p16 protein. CONCLUSIONS: We speculate that not only genetic but also epigenetic alterations are involved in the carcinogenesis due to chromium.
(キーワード): Adult / Aged / Chromates / Chromium / Cyclin-Dependent Kinase Inhibitor p16 / DNA (DNA) / DNA Methylation / Epigenesis, Genetic / Gene Expression Regulation, Neoplastic / Humans / Lung Neoplasms / Male / Middle Aged / Occupational Exposure / Sulfites
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.lungcan.2006.05.022
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16828922; ● Search Scopus @ Elsevier (PMID): 16828922; ● Search Scopus @ Elsevier (DOI): 10.1016/j.lungcan.2006.05.022

(DOI: 10.1016/j.lungcan.2006.05.022, PubMed: 16828922) Hiromitsu Takizawa, Kazuya Kondo, H Fujino, Koichiro Kenzaki, T Miyoshi, Shoji Sakiyama and A Tangoku :
The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer.,
British Journal of Cancer, Vol.95, No.1, 75-79, 2006.

(要約): A positive association between vascular endothelial growth factor-C (VEGF-C) expression and lymph node metastasis has been reported in several cancers. However, the relationship of VEGF-C and lymph node metastasis in some cancers, including non-small cell lung cancer (NSCLC), is controversial. We evaluated the VEGF-C and vascular endothelial growth factor receptor-3 (VEGFR-3) expression in NSCLC samples from patients who had undergone surgery between 1998 and 2002 using real-time quantitative RT-PCR and immunohistochemical staining. We failed to find a positive association between VEGF-C and VEGFR-3 mRNA expression and lymph node metastasis in NSCLC. An immunohistological study demonstrated that VEGF-C was expressed not only in cancer cells, but also in macrophages in NSCLC, and that VEGFR-3 was expressed in cancer cells, macrophages, type II pneumocytes and lymph vessels. The VEGF-C/VEGFR-3 ratio of the node-positive group was significantly higher than that of the node-negative group. Immunohistochemical staining showed that VEGFR-3 was mainly expressed in cancer cells. The immunoreactivity of VEGF-C and VEGFR-3 was roughly correlated to the mRNA levels of VEGF-C and VEGFR-3 in real-time PCR. VEGF-C mRNA alone has no positive association with lymph node metastasis in NSCLC. The VEGF-C/VEGFR-3 ratio was positively associated with lymph node metastasis in NSCLC. This suggests that VEGF-C promotes lymph node metastasis while being influenced by the strength of the VEGF-C autocrine loop, and the VEGF-C/VEGFR-3 ratio can be a useful predictor of lymph node metastasis in NSCLC.
(キーワード): Adult / Aged / Aged, 80 and over / Carcinoma, Non-Small-Cell Lung / Female / Gene Expression Profiling / Humans / Immunohistochemistry / Lung Neoplasms / Lymph Nodes / Lymphatic Metastasis / Male / Middle Aged / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Vascular Endothelial Growth Factor C / Vascular Endothelial Growth Factor Receptor-3
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/sj.bjc.6603209
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16755294; ● Search Scopus @ Elsevier (PMID): 16755294; ● Search Scopus @ Elsevier (DOI): 10.1038/sj.bjc.6603209

(DOI: 10.1038/sj.bjc.6603209, PubMed: 16755294) 監﨑孝一郎, 先山正二, 近藤和也, 吉田光輝, 長尾妙子, 中川靖士, 滝沢宏光, 三好孝典, 丹黒章 :
胸部外科の指針原発性肺癌における手術死亡および在院死亡,
胸部外科, Vol.59, No.5, 347-52, 2006年.

(要約): In our department, there were 313 thoracic surgeries for primary lung cancer from January 1994 to December 2003. We clinically reviewed for the operative and hospital death (n=18, 5.8%). The patients were 16 males and 2 females (70.6 +/- 5.6 years old). The surgical procedures were 4 pneumonectomies, 13 lobectomies (3 bronchoplasties) and 1 partial resection. The mean interval until postoperative death was 122.5 +/- 156.1 days. There were 5 direct operative deaths within 30 days (1.6%). There were 4 cancer deaths, 2 hemoptyses, 2 operative bleeding, 2 thromboses, 2 cerebral hemorrhages, 1 pyothorax, 1 pneumonia, 1 respiratory failure, 1 multiple organ failure after chemotherapy and 2 unexplained deaths. The patients with pneumonectomy or aged significantly had high mortality. For postoperative complications such as hemoptysis or bleeding, perioperative management that takes these issues into consideration is needed. Furthermore, we must carefully review the preoperative evaluation and combined treatment, because there were many cancer deaths among cases showing early recurrence and metastasis.
(キーワード): Adenocarcinoma / Aged / Aged, 80 and over / Carcinoma, Squamous Cell / Female / Hospital Mortality / Humans / Lung Neoplasms / Male / Middle Aged / Pneumonectomy
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16715882; ● Search Scopus @ Elsevier (PMID): 16715882

(PubMed: 16715882) Koichiro Kenzaki, Shoji Sakiyama, Kazuya Kondo, Mitsuteru Yoshida, Yukikiyo Kawakami, Masatsugu Takehisa, Hiromitsu Takizawa, Takanori Miyoshi, Yoshimi Bando, Akira Tangoku and Mingyao Liu :
Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma.,
Journal of Thoracic and Cardiovascular Surgery, Vol.131, No.5, 1148-1153, 2006.

(要約): OBJECTIVE: The capability of regeneration of lung tissues in adults is limited after chronic destruction. Bone marrow-derived stem cells, retinoic acid, growth factors, and other approaches have been attempted to promote or facilitate this process. We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration. METHODS: Day 17 fetal lung tissue fragments at the pseudoglandular stage of lung development from Lewis rats were implanted into adult Lewis rat lungs. For group 1, fetal lung fragments were injected into the adult left lung parenchyma; for group 2, fetal fragments were injected with the left lung partially resected; for group 3, adult fragments were injected; and for groups 4 and 5, fetal fragments were implanted into the omentum and subcutaneous tissue, respectively. RESULTS: The grafts implanted into pulmonary parenchyma were differentiated with opening of the alveolar space after 4 weeks and were advanced further with morphologic features similar to those of neonatal lungs after 8 and 12 weeks. The implants were connected with pulmonary circulation determined by means of perfusion with India ink. These changes appeared to be further enhanced in animals with partial lung resection that might have facilitated the maturation of implanted fetal lung tissues through mechanical factors, soluble factors, or both. Fetal lung tissues did not mature when implanted into the omentum or subcutaneous tissue. Adult lung fragments did not expand after being reimplanted back into the same animal. CONCLUSIONS: Fetal lung tissue might be an option for further investigation into lung regeneration.
(キーワード): Age Factors / Animals / Female / Fetus / Lung / Lung Transplantation / Models, Animal / Pneumonectomy / Pregnancy / Rats / Rats, Inbred Lew / Regeneration
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2005.11.041
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16678603; ● Search Scopus @ Elsevier (PMID): 16678603; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2005.11.041

(DOI: 10.1016/j.jtcvs.2005.11.041, PubMed: 16678603) Takanori Miyoshi, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kenzaki, Haruhiko Fujino, Shoji Sakiyama and Akira Tangoku :
Fluoroscopy-assisted thoracoscopic resection of pulmonary nodules after computed tomography--guided bronchoscopic metallic coil marking.,
Journal of Thoracic and Cardiovascular Surgery, Vol.131, No.3, 704-710, 2006.

(要約): OBJECTIVE: To localize small and deeply situated pulmonary nodules during thoracoscopy with roentgenographic fluoroscopy, we developed a marking procedure that uses a metallic coil. METHODS: Nine patients underwent video-assisted thoracoscopic surgery for the removal of 11 pulmonary lesions. Fluoroscopy-assisted thoracoscopic surgery after computed tomography-guided bronchoscopic metallic coil marking was performed with an ultrathin bronchoscope, with simulation by means of virtual bronchoscopy. During thoracoscopy, a C-arm-shaped roentgenographic fluoroscope was used to detect the radiopaque nodules. RESULTS: The marking procedure took 15 to 60 minutes from insertion to removal of the bronchoscope. There were no complications from the marking, and all 11 nodules were easily localized by means of thoracoscopy. The metallic coil showed the nodules on the fluoroscopic monitor, which aided in nodule manipulation. Nodules were completely resected under thoracoscopic guidance, except in one case in which a minithoracotomy was performed at an early stage of the trial. The pathologic diagnosis was primary adenocarcinoma in 9 patients, pulmonary metastasis from colon cancer in 1 patient, and pulmonary lymph node in 1 patient. Two cases of bronchioloalveolar adenocarcinoma with an invasive component and a well-differentiated adenocarcinoma were converted to open thoracotomy to perform curative lobectomy. CONCLUSIONS: In this pilot study computed tomography-guided transbronchial metallic coil marking with an ultrathin bronchoscope with virtual bronchoscopic simulation might be a useful method for the fluoroscopy-assisted thoracoscopic resection of pulmonary nodules.
(キーワード): Adult / Aged / Aged, 80 and over / Bronchoscopes / Bronchoscopy / Female / Fluoroscopy / Humans / Lung Neoplasms / Male / Middle Aged / Pilot Projects / Reproducibility of Results / Thoracic Surgery, Video-Assisted / Thoracoscopy / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2005.09.019
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16515927; ● Search Scopus @ Elsevier (PMID): 16515927; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2005.09.019

(DOI: 10.1016/j.jtcvs.2005.09.019, PubMed: 16515927) Haruhiko Fujino, Kazuya Kondo, Hisashi Ishikura, Hideo Maki, Hidetaka Kinoshita, Takanori Miyoshi, Yuji Takahashi, Naruhiko Sawada, Hiromitsu Takizawa, Taeko Nagao, Shoji Sakiyama and Yasumasa Monden :
Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer,
Molecular Cancer Therapeutics, Vol.4, No.9, 1409-1416, 2005.

(要約): Matrix metalloproteinases (MMP) are considered to be critically involved in tumor invasion and the metastasis of various cancers. MMI-166 is a selective inhibitor of matrix metalloproteinase (MMP-2, MMP-9, and MMP-14). The purpose of this study was to evaluate the effects of MMI-166 on both the growth of the implanted tumor and the lymph node metastasis of the mediastinum and prolonging the life span, using an orthotopic implantation model of the Ma44-3 cancer cell line. We examined the anti-invasive effect of MMI-166 in lung cancer cell lines using an in vitro invasion assay. Next, we examined the anticancer effect of MMI-166 in vivo. MMI-166 (200 mg/kg body weight) or a vehicle was administered orally to the orthotopically implanted lung cancer model. MMI-166 dose-dependently inhibited the invasion of cancer cell lines with expressions of MMP-2 and/or MMP-9 in vitro. In vivo, MMI-166 significantly inhibited mediastinal lymph node metastasis in this orthotopic model (weight of the mediastinum: control, 0.089 +/- 0.009 versus MMI-166, 0.069 +/- 0.008 mg; P = 0.005; metastatic area: control, 93,495 +/- 55,747 versus MMI-166, 22,747 +/- 17,478 pixels; P = 0.045). MMI-166 prolonged the life span by 6 days in median survival time in the orthotopically implanted model (P = 0.039). These results showed that MMI-166 could possibly inhibit lymph node metastasis and prolong the life span in lung cancer patients.
(キーワード): Animals / Carcinoma, Non-Small-Cell Lung / Disease Models, Animal / Humans / Injections, Subcutaneous / Lung Neoplasms / Lymphatic Metastasis / Male / Matrix Metalloproteinases / Mice / Mice, SCID / Neoplasm Invasiveness / Neovascularization, Pathologic / Sulfonamides / Survival Rate / Tumor Cells, Cultured
(出版サイトへのリンク): ● Publication site (DOI): 10.1158/1535-7163.MCT-05-0031
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16170033; ● Search Scopus @ Elsevier (PMID): 16170033; ● Search Scopus @ Elsevier (DOI): 10.1158/1535-7163.MCT-05-0031

(DOI: 10.1158/1535-7163.MCT-05-0031, PubMed: 16170033) Kazuya Kondo, Takanori Miyoshi, Hiromitsu Takizawa, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Photodynamic therapy for submucosal tumor of the central bronchus,
The Journal of Medical Investigation : JMI, Vol.52, No.3,4, 208-211, 2005.

(要約): A 75-year-old man was referred to our hospital because of the emphysema and tumor of the right intermediate bronchus. Thoracic CT scan and bronchoscopic examination demonstrated a spherical tumor of the right intermediate bronchus covering a normal mucosa. The biopsy specimen obtained from this tumor was histologically diagnosed as "glandular type of adenocarcinoma in the bronchus". Surgical treatment was not feasible because of poor pulmonary function. Therefore, the patient underwent Photodynamic therapy (PDT) using porfimer sodium (Photofrin) and an excimer dye laser. After 4 months, the tumor disappeared and there has been no recurrence for 3 years 3 months. PDT can affect a submucosal tumor of the central airway, and is safe for patients with poor pulmonary function. Our report recommends that PDT should be applied not only to early lung cancer but also submucosal tumor of the central bronchus.
(キーワード): photodynamic thera / 肺癌 (lung cancer) / submucosal tumor / central airway
(徳島大学機関リポジトリ): ● Metadata: 110779
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.52.208
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16167540; ● Search Scopus @ Elsevier (PMID): 16167540; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.52.208

(徳島大学機関リポジトリ: 110779, DOI: 10.2152/jmi.52.208, PubMed: 16167540) Tadashi Kondo, Junji Ueno and Kazuya Kondo :
Revised GMDH-type Neural Networks using AIC or PSS Criterion and Their Application to the Medical Image Recognition,
Journal of Advanced Computational Intelligence and Intelligent Informatics, Vol.9, No.3, 257-267, 2005.

(キーワード): ニューラルネットワーク (neural network) / 医療情報学 (medical infomatics)

Shoji Sakiyama, Kazuya Kondo, Mitsuteru Yoshida, Hiromitsu Takizawa, Koichiro Kenzaki, Takanori Miyoshi, Masahiro Abe, Shingo Wakatsuki and Yasumasa Monden :
Extramedullary plasmacytoma immunoglobulin D (λ) in the chest wall and the subglottic region,
Journal of Thoracic and Cardiovascular Surgery, Vol.129, No.5, 1168-1169, 2005.

(キーワード): Antineoplastic Combined Chemotherapy Protocols / Biopsy / Dexamethasone / Doxorubicin / Female / Glottis / Humans / Immunoglobulin D / Ki-67 Antigen / Laryngeal Neoplasms / Magnetic Resonance Imaging / Middle Aged / Neoplasms, Second Primary / Plasmacytoma / Prognosis / Radiotherapy, Adjuvant / Rare Diseases / Remission, Spontaneous / Thoracic Neoplasms / Thoracic Wall / Tomography, X-Ray Computed / Vincristine
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.jtcvs.2004.08.037
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15867795; ● Search Scopus @ Elsevier (PMID): 15867795; ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2004.08.037

(DOI: 10.1016/j.jtcvs.2004.08.037, PubMed: 15867795) Takanori Miyoshi, Kazuya Kondo, Haruhiko Fujino, Yuji Takahashi, Naruhiko Sawada, Shoji Sakiyama, Masaru Tsuyuguch, Suguru Kimura, Masayuki Sumitomo and Yasumasa Monden :
Thymidylate Synthase and Dihydropyrimidine Dehydrogenase in Non-small Cell Lung Cancer: Relationship between mRNA Expression and Activity,
Anticancer Research, Vol.25, No.2A, 923-930, 2005.

(要約): UFT (Tegafur + Uracil) has been reported to be effective for postoperative adjuvant chemotherapy of non-small cell lung cancer (NSCLC) in a randomized prospective study. Recently, many clinical studies have demonstrated that UFT is effective for cancer with a low activity of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD). In the present study, we investigated TS and DPD activity in resected tumors and corresponding normal lungs and the relationship between the activity and the mRNA expression of TS and DPD in NSCLC. Seventy-seven patients underwent complete surgical resection and lymph node dissection for NSCLC. The activity of TS was determined by the FdUMP binding assay combined with gel filtration. The activity of DPD was determined by radio-enzymatic assay. Tumor tissues and their paired non-cancerous tissues were assayed. Furthermore, the mRNA expressions of TS and DPD were examined by real-time RT-PCR. The mean TS and DPD activities in NSCLC were approximately 2.4-fold and 5-fold of those in normal lungs. The mean TS and DPD activities of NSCLC were 0.099 pmol/mg and 407 pmol/mg/min, respectively. Although both TS and DPD activities showed a tendency to be high for adenocarcinoma, there was no significant difference between TS and/or DPD activities and any clinical findings (age, gender, stage and histological type). The mRNA expression of DPD was correlated with DPD activity (rs=0.846, p<0.001). The mRNA expression of TS was weakly correlated with TS activity (rs=0.757, p<0.001). TS and DPD activities in NSCLC were higher than those in normal lungs. Assay of DPD mRNA and TS mRNA by real-time RT-PCR can be used as an indicator for the use of UFT.
(キーワード): Thymidylate Syuthase (TS) / Dihydropyrimidine Drhydrogenase (DPD) / Non-small Lung Cancer / RT-PCR
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15868929; ● Search Scopus @ Elsevier (PMID): 15868929

(PubMed: 15868929) Kazuya Kondo, Haruhiko Fujino, Takanori Miyoshi, Hisashi Ishikura, Shoji Sakiyama and Yasumasa Monden :
Orthotopically implanted SCID mouse model of human lung cancer suitable for investigating metastatic potential and anticancer drug effects,
Oncology Reports, Vol.12, No.5, 991-999, 2004.

(要約): To evaluate the effects of drugs in clinical settings, an animal model of lung cancer similar to clinical cancer is necessary. Our previous studies described an SCID mouse model using orthotopic implantation of the human lung cancer cell line which mimicked the lymph node metastasis of patients with lung cancer. In this study, we made animal models that reflected various metastatic forms of lung cancer in humans. We applied our procedure to 6 lung cancer cell lines. Suspensions of 2.0 x 10(4) cancer cells were injected into the left lung of SCID mice. We evaluated the mRNA expressions of 52 proteins related to the metabolism of and resistance to anticancer drugs of each tumor cell line and its orthotopically implanted tumor using a customized cDNA array. Three lung cancer cell lines had the potential of lymphogenous metastasis and 3 cell lines had the potential of hematogenous metastasis in this model system. The A549 line showed multiple metastases, and Ma2 line showed solitary metastasis. The expression of 52 genes in each implanted tumor was closely correlated with that in each cell lines (correlation coefficients: 0.8883-0.9533), and the gradient of the regression line was more than 0.9. This model was similar to the metastatic form in patients with lung cancer. The similar expression of proteins in each tumor cell line in vitro and implanted tumor in vivo gives an advantage in evaluating the effects of molecular-targeted drugs and the relationship between specific genes and tumor potential in preclinical studies.
(キーワード): lymphogenous metastasis / hematogenous metastasis / customized cDNA array / orthotopic model
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15492783; ● Search Scopus @ Elsevier (PMID): 15492783

(PubMed: 15492783) Naruhiko Sawada, Keiko Kataoka, Kazuya Kondo, Hideki Arimochi, H Fujino, Y Takahashi, Takanori Miyoshi, Tomomi Kuwahara, Y Monden and Yoshinari Ohnishi :
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice,
British Journal of Cancer, Vol.90, No.8, 1672-1678, 2004.

(要約): We examined the antitumour effect of a combination of betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro and in vivo. Betulinic acid, a pentacyclic triterpene, showed a synergistic cytotoxic effect on melanoma cells by combinational use of VCR. Betulinic acid and VCR induced cell cycle arrest at different points (BA at G1 phase and VCR at G2/M phase) and caused apoptosis in B16F10 melanoma cells. In the in vivo study, VCR inhibited metastasis of tumour cells to the lung. The addition of BA to VCR augmented suppression of the experimental lung metastasis of melanoma cells in C57BL/6 mice. The number of lung nodules of more than 1 mm in diameter in mice treated with BA and VCR was less than that in mice treated with VCR alone. These results suggest that BA is an effective supplement for enhancing the chemotherapeutic effect on malignant melanoma.
(キーワード): synergistic antitumour effect / betulinic acid / vincristine / cell cycle arrest / G1 phase
(出版サイトへのリンク): ● Publication site (DOI): 10.1038/sj.bjc.6601746
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15083202; ● Search Scopus @ Elsevier (PMID): 15083202; ● Search Scopus @ Elsevier (DOI): 10.1038/sj.bjc.6601746

(DOI: 10.1038/sj.bjc.6601746, PubMed: 15083202) Kazuya Kondo, Kiyoshi Yoshizawa, Masaru Tsuyuguchi, Suguru Kimura, Masayuki Sumitomo, Junji Morita and Takanori Miyoshi :
WHO histologic classification is a prognostic indicator in thymoma,
The Annals of Thoracic Surgery, Vol.77, No.4, 1183-1188, 2004.

(要約): The histologic classification of thymoma has remained a subject of controversy for many years. In 1999, the World Health Organization Consensus Committee published a histologic typing system for tumors of the thymus. We reclassified a series of 100 thymomas resected at Tokushima University Hospital and four affiliated hospitals in Japan between 1973 and 2001 according to the World Health Organization histologic classification and reported its clinicopathologic relationship and prognostic relevance. There were 8 type A, 17 type AB, 27 type B1, 8 type B2, 12 type B3, and 28 type C thymomas. The frequency of invasion to neighboring organs increased according to tumor subtype in the order A (0%), AB (6%), B1 (19%), B2 (25%), B3 (42%), and C (89%). There was no recurrence in patients with type A, AB, or B2 thymoma. The recurrence rates of patients with B1, B3, or C thymoma were 15%, 36%, and 47%, respectively. The disease-free survival rates were 100% for types A and AB, 83% for types B1 and B2, 36% for type B3, and 28% for type C thymoma at 10 years. There were significant differences in disease-free survival between types A and AB and types B1 and B2 (p = 0.0436), and between type B3 and type C (p = 0.042). By multivariate analysis, only Masaoka clinical stage (p = 0.002) showed significant independent effects on disease-free survival. The 10-year survival rates of types A and AB, types B1 and B2, type B3, and type C thymoma were 100%, 94%, 92%, and 58%, respectively. The current study confirmed the World Health Organization histologic classification as a good prognostic factor.
(キーワード): THYMIC EPITHELIAL TUMORS / SUBCLASSIFICATION
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.athoracsur.2003.07.042
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15063231; ● Search Scopus @ Elsevier (PMID): 15063231; ● Search Scopus @ Elsevier (DOI): 10.1016/j.athoracsur.2003.07.042

(DOI: 10.1016/j.athoracsur.2003.07.042, PubMed: 15063231) Hisashi Ishikura, Kazuya Kondo, Takanori Miyoshi, Yuji Takahashi, Haruhiko Fujino and Yasumasa Monden :
Green fluorescent protein expression and visualization of mediastinal lymph node metastasis of human lung cancer cell line using orthotopic implantation,
Anticancer Research, Vol.24, No.2B, 719-723, 2004.

(要約): Suppression of lymphatic metastasis improves survival in lung cancer patients. We have reported a patient-like model of lung cancer metastasis based on orthotopic implantation in severe combined immunodeficiency (SCID) mice and demonstrated the lymphogenous spread histologically using human NSCLC cell lines. To visualize micrometastases, we transfected the Aequorea Victoria jellyfish green fluorescent protein (GFP) gene to the cancer cell line. The tumor cell lines were able to stably express GFP at high levels both in vitro and in vivo. Fluorescent tumors and metastasis of the mediastinum could be visualized at microscopic levels after transplantation. This model demonstrated that GFP gene-transfected tumor cells represent a new tool for evaluating the metastatic process and are very useful for developing chemotherapy to inhibit metastasis.
(キーワード): GFP / Orthotopic Implantation / SCID MIce / Lung Cancer / Model
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15161017; ● Search Scopus @ Elsevier (PMID): 15161017

(PubMed: 15161017) Haruhiko Fujino, Kazuya Kondo, Takanori Miyoshi, Hisashi Ishikura, Yuji Takahashi, Naruhiko Sawada, Yukiko Hirose, Hiromitsu Takizawa, Taeko Nagao, Shoji Sakiyama and Yasumasa Monden :
Establishment of patient-like SCID mouse model by orthotopically implanting primary cultured cells from surgically-resected lung cancer tissues,
Oncology Reports, Vol.10, No.6, 1709-1715, 2003.

(要約): In our previous studies, we established a lymphogenous metastatic SCID mouse model using orthotopic implantation of human lung cancer cell lines. However, the lymphogenous metastatic potential of each cell line in our models does not reflect that of a primary tumor. In this study, we made orthotopic implanted models using primary cultured cells from surgically-resected lung cancer tissues. Tissues of 5 patients with non-small cell lung cancer (NSCLC) were applied to a primary culture method using a collagen gel coated flask. Suspensions of 2.0x10(4) cancer cells were injected into the left lung of SCID mice. We could maintain primary culture cells from 2 (FM205 and FT821 cells) of 5 lung cancers, and made orthotopically implanted SCID mouse models. The size of both tumors in implanted sites of the lung increased with time. The FM205 cells microscopically were metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 16 weeks. The FT821 cells were microscopically metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 6 weeks. The lymphogenous metastatic potential of these primary culture cells was similar to that of clinical tumors. As the lymphogenous metastatic potential of this model reflects that of the clinical tumor, it is useful for elucidating the mechanism of lymphogenous metastasis and selecting anticancer drugs suitable for an individual patients.
(キーワード): 肺癌 (lung cancer) / 生物学 (biology) / Mediastinal Lymph Nodes / Non-Small Cell Lungg Cancer / Surgical Operation / Xenograft
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14534683; ● Search Scopus @ Elsevier (PMID): 14534683

(PubMed: 14534683) Kazuya Kondo, Yuji Takahashi, Sumiyo Ishikawa, Hiroshi Uchihara, Yukiko Hirose, Kiyoshi Yoshizawa, Masaru Tsuyuguchi, Hiromitsu Takizawa, Takanori Miyoshi, Shoji Sakiyama and Yasumasa Monden :
Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers,
Cancer, Vol.98, No.11, 2420-2429, 2003.

(要約): It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma. The authors used a microscopic X-ray fluorescence analyzer with transmitted X-ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers. The maximum chromium accumulation (mean +/- standard deviation) in 10 resected lung tissue specimens was 197 +/- 238 counts per second (cps)/mili ampere (mA) (range, 4-649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 +/- 9.2 cps/mA (range, 0-46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non-chromate workers were 20.2 +/- 5.4, 18.3 +/- 12.2, 13.2 +/- 13.4, and 3.0 +/- 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003). Previous studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium-induced lung carcinoma.
(キーワード): Chromium / accumulation / Lung Carcinoma / Chromate Worker / Bronchs / Lung Tissue Specimens
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cncr.11818
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14635077; ● Search Scopus @ Elsevier (PMID): 14635077; ● Search Scopus @ Elsevier (DOI): 10.1002/cncr.11818

(DOI: 10.1002/cncr.11818, PubMed: 14635077) Shoji Sakiyama, Kazuya Kondo, Hisashi Matsuoka, Mitsuteru Yoshida, Takanori Miyoshi, Shusaku Yoshida and Monden Yasumasa :
Fatal air embolism during computed tomography guided pulmonary marking with a hook-type marker,
Journal of Thoracic and Cardiovascular Surgery, Vol.126, No.4, 1207-1209, 2003.

(キーワード): Adenocarcinoma / Aged / Embolism, Air / Fatal Outcome / Female / Humans / Lung Neoplasms / Tomography, X-Ray Computed
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0022-5223(03)00821-3
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14566279; ● Search Scopus @ Elsevier (PMID): 14566279; ● Search Scopus @ Elsevier (DOI): 10.1016/S0022-5223(03)00821-3

(DOI: 10.1016/S0022-5223(03)00821-3, PubMed: 14566279) Ken-ichi Sogawa, Kazuya Kondo, Haruhiko Fujino, Yuji Takahashi, Takanori Miyoshi, Shoji Sakiyama, Kiyoshi Mukai and Yasumasa Monden :
Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors,
Cancer, Vol.98, No.9, 1811-1821, 2003.

(要約): A distinction between noninvasive, invasive, and metastatic thymoma on the basis of the cytologic features is difficult. The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma. Tumor tissue samples were obtained from 42 patients with thymic epithelial tumors between 1974 and 2001 at Tokushima University Hospital. Three-micrometer-thick, formalin-fixed, paraffin-embedded tissue sections were immunostained using specific antibodies against MMP-2, MMP-9, TIMP-1, and TIMP-2. MMP-2 expression was detected in 30 tumors (71%), and TIMP-2 expression was detected in 31 tumors (74%). MMP-9 expression was detected in 22 of 36 tumors (61%), and TIMP-1 expression was detected in only 7 tumors (19%). MMP-2 and TIMP-2 expression levels were very low (10% and 0%, respectively) in noninvasive tumors but were very high (91% and 97%, respectively) in invasive tumors. In thymic epithelial tumors, the more progressive the clinical stage of tumor, the higher the strongly positive rate of MMP-2 and TIMP-2 expression. There was no correlation between positivity for MMP-9 and stage. Twenty-five percent of Type AB thymomas and 50% of Type B1 thymomas expressed MMP-2 and TIMP-2. Most of Type A, Type B2, Type B3, and Type C thymomas expressed MMP-2 and TIMP-2. There were significant differences in disease-free survival at 5 years between patients without and with MMP-2 expression (91% vs. 55%, respectively) and patients without and with TIMP-2 expression (100% vs. 53%, respectively). MMP-2 and TIMP-2 are key enzymes for invasiveness of thymic epithelial tumors. The expression of these proteins can predict a poor outcome in patients with thymoma.
(キーワード): thymoma / matrix metalloproteinase / tissue inhibitor of metalloproteinase / invasiveness / 免疫組織化学 (immunohistochemistry)
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/cncr.11725
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14584061; ● Search Scopus @ Elsevier (PMID): 14584061; ● Search Scopus @ Elsevier (DOI): 10.1002/cncr.11725

(DOI: 10.1002/cncr.11725, PubMed: 14584061) Yoshifumi Takehisa, Shoji Sakiyama, Tadashi Uyama, Masayuki Sumitomo, Masafumi Tamaki, Hiroyuki Hino, Masatsugu Takehisa, Mingyao Liu, Kazuya Kondo and Yasumasa Monden :
Progressive increase of CD4⁺/CD45RC^- lymphocytes after allograft rat lung transplantation: a marker of acute rejection,
Journal of Thoracic and Cardiovascular Surgery, Vol.124, No.4, 675-683, 2002.

(要約): Acute rejection remains one the most serious problems in lung transplantation. Although biopsy has been used for assessing the dysfunction of grafts, it is difficult to determine rejection at an early stage. Lymphocyte infiltration and activation play an important role in acute rejection of transplanted organs, and the dynamic change of lymphocyte subpopulations might be a marker to determine graft rejection after lung transplantation. A rat lung transplant model was used. Graft-infiltrating lymphocytes in lung tissues were examined by means of histology, and isolated cells were analyzed by means of flow cytometry. Phenotypes of lymphocytes in the regional and remote lymph nodes, spleen, peripheral blood, and bronchoalveolar lavage fluid were also measured by means of flow cytometry. After allograft transplantation, increased lymphocytes were seen in allografts but not in isografts. In allografts the percentage of T cells increased from day 1 to day 5, whereas that of B cells was decreased. The CD4(+)/CD8(+) ratio decreased in allografts. The proportion of CD4(+)/CD45RC(-) cells increased in the allografts, which was mainly due to the increase of CD45RC(-) cells in the total CD4(+) cells. Similar changes were found in regional mediastinal lymph nodes but not in the mesenteric lymph nodes, spleen, or peripheral blood. Thus this is a specific response to lung allografts. Importantly, CD45RC(-) cells were significantly increased in the bronchoalveolar lavage fluid. Significant change of lymphocyte subpopulations is a sign of lymphocyte activation. Increased CD4(+)/CD45RC(-) cells in lung allografts could be an early marker of acute rejection, which can be examined by means of lung lavage and flow cytometry.
(キーワード): Acute Disease / Animals / Antigens, CD45 / Biomarkers / CD4-Positive T-Lymphocytes / Graft Rejection / Lung Transplantation / Male / Models, Animal / Rats / Rats, Inbred Lew / Time Factors
(出版サイトへのリンク): ● Publication site (DOI): 10.1067/mtc.2002.126043
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12324724; ● Search Scopus @ Elsevier (PMID): 12324724; ● Search Scopus @ Elsevier (DOI): 10.1067/mtc.2002.126043

(DOI: 10.1067/mtc.2002.126043, PubMed: 12324724) Hisashi Ishikura, Kazuya Kondo, Takanori Miyoshi, Hidetaka Kinoshita, Yuji Takahashi, Haruhiko Fujino and Yasumasa Monden :
Suppression of mediastinal metastasis by uracil-tegafur or cis-diamminedichloroplatinum(II) using a lymphogenous metastatic model in a human lung cancer cell line,
Clinical Cancer Research, Vol.7, No.12, 4202-4208, 2001.

(要約): The extent of lymphatic metastasis is the most important factor in the prognosis for non-small cell lung cancer (NSCLC). Therefore, suppression of lymphatic metastasis provides an improvement in survival time in lung cancer patients. We established a new patient-like model for lung cancer metastasis by orthotopic implantation in severe combined immunodeficiency (SCID) mice and demonstrated the lymphogenous spread histologically using human NSCLC cell lines. The cardinal features of this model are a simple procedure and a similarity to the metastatic form of human lung cancer. The purpose of this study is to assess the inhibitory action of uracil-tegafur (UFT) and cis-diamminedichloroplatinum(II) (CDDP) on lymphatic metastasis and life span prolongation in our lymphogenous metastatic model system using SCID mice. The inhibition ratios of mediastinal lymph node metastasis were 86.2, 94, and 92.1% for 12 mg/kg body UFT, 17 mg/kg body UFT, and 10 mg/kg body CDDP, respectively. The administration of anticancer drugs prolonged the life span by 4.6 days (17 mg/kg body UFT) and 8 days (10 mg/kg body CDDP) in MST. We demonstrated that UFT alone and CDDP alone suppressed mediastinal metastasis and prolonged the life span in our lymphogenous metastatic model. Regardless of the administration route and characteristics of anticancer drugs, cytostatic or cytotoxic, our model is capable of evaluating the inhibitory effect of drugs on lymphatic metastasis. This model should make an important contribution to our understanding of the mechanism and selection of drugs for antilymphatic metastasis in lung cancer.
(キーワード): Animals / Antimetabolites, Antineoplastic / Carcinoma, Non-Small-Cell Lung / Cisplatin / Humans / Lung Neoplasms / Lymphatic Metastasis / Male / Mice / Mice, SCID / Models, Biological / Neoplasm Metastasis / Survival / Tegafur / Time Factors / Transplantation, Heterologous / Tumor Cells, Cultured / Uracil
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11751521; ● Summary page in Scopus @ Elsevier: 2-s2.0-0035679779

(PubMed: 11751521, Elsevier: Scopus) Kazuya Kondo, Takanori Miyoshi, Syouji Sakiyama, Yukio Shimosato and Yasumasa Monden :
Multilocular thymic cyst associated with Sjögren's syndrome,
The Annals of Thoracic Surgery, Vol.72, No.4, 1367-1369, 2001.

(要約): A 61-year-old woman, who had been diagnosed as having Sjögren's syndrome, developed an anterior mediastinal mass. She was diagnosed with Sjögren's syndrome with thymoma, preoperatively. Extended thymectomy was performed. Macroscopically, the mediastinal mass showed thick-walled multiloculated cavities filled with turbid yellow fluid. Microscopically, the cyst lining was continuous with thymic lobules in the wall with inflammatory process, cholesterol granuloma formation, and prominent lymph follicular hyperplasia. She was diagnosed with multilocular thymic cysts associated with Sjögren's syndrome.
(キーワード): Female / Humans / Mediastinal Cyst / Middle Aged / シェーグレン症候群 (Sjögren's syndrome) / Thymectomy / Thymus Gland
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/S0003-4975(00)02706-5
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11603465; ● Search Scopus @ Elsevier (PMID): 11603465; ● Search Scopus @ Elsevier (DOI): 10.1016/S0003-4975(00)02706-5

(DOI: 10.1016/S0003-4975(00)02706-5, PubMed: 11603465) 先山正二, 監﨑孝一郎, 武久政嗣, 高橋裕児, 石倉久嗣, 武久良史, 谷田信行, 近藤和也, 高橋敬治, 門田康正 :
血中CA19-9およびCA125上昇を認めた肺葉内肺分画症の一例,
日本呼吸器外科学会雑誌, Vol.14, No.6, 26(708)-32(714), 2000年.

(キーワード): 肺分画症 / 肺葉内肺分画症 / CA19-9 / CA125

Takanori Miyoshi, Kazuya Kondo, Hisashi Ishikura, Hidetaka Kinoshita, Yasumichi Matsumori and Yasumasa Monden :
SCID mouse lymphogenous metastatic model of human lung cancer constructed using orthotopic inoculation of cancer cells,
Anticancer Research, Vol.20, No.1A, 161-163, 2000.

(要約): An animal model of metastasis with features similar to those of lung cancer metastasis in humans is required for an understanding of the cellular and molecular mechanisms of human lung cancer metastasis. Ma-44 cell lines derived from human squamous cell lung cancer were percutaneously injected (2-3 x 10(4)) into the left lung of SCID mice. After orthotopic implantation, Ma-44 cell lines formed tumors in the left lung at a high rate (17/25, 68%), and many of those metastasized to mediastinal lymph nodes (13/17, 76%) by the 14th day, but not to other organs. After the ectopic implantation, the Ma-44 cell line inoculated subcutaneously (2-3 x 10(5)) formed a tumor at the inoculation site by the 28th day (all mice), but did not metastasize to any organs. The Ma-44 cell line inoculated intravenously (2-3 x 10(5)) formed metastases in the lungs (37/50, 74%), and these pulmonary metastases metastasized to the mediastinal lymph nodes at low rate (3/37, 8%) by the 14th day. The orthotopic sites of implantation are critical for the metastatic ability of transplanted tumors in SCID mice. Since non-small cell lung cancer (NSCLC) grows at the primary site in humans, lymphogenous metastasis occurs frequently, and blood-born metastasis occurs at moderate rate, our orthotopic SCID mice model was similar to the metastatic behavior of NSCLC in humans. Thus, this model may be useful for elucidating the mechanism of lymphogenous metastasis in human lung cancer, and testing the anti-metastatic efficacy of therapeutic agents in vivo.
(キーワード): Lung Cancer / Lymphogenous Metastasis model / SCID Mouse / orthotopic implantation
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10769649; ● Summary page in Scopus @ Elsevier: 2-s2.0-0034070118

(PubMed: 10769649, Elsevier: Scopus) Takanori Miyoshi, Kazuya Kondo, Naoki Hino, Tadashi Uyama and Yasumasa Monden :
The expression of the CD44 variant exon 6 is associated with lymph node metastasis in non-small cell lung cancer,
Clinical Cancer Research, Vol.3, No.8, 1289-1297, 1997. N Hino, Kazuya Kondo, Takanori Miyoshi, T Uyama and Yasumasa Monden :
High frequency of p53 protein expression in thymic carcinoma but not in thymoma.,
British Journal of Cancer, Vol.76, No.10, 1361-1366, 1997.

(要約): Thymic epithelial tumours are broadly classified into thymomas and thymic carcinomas. Although both tumours occasionally show invasive growth, they exhibit different clinical and biological findings. The oncogene and anti-oncogene in thymic epithelial tumours have not been evaluated fully. We investigated the expression of p53 protein by immunohistochemical analysis using the anti-p53 polyclonal antibody (CM-1) in 17 thymomas and 19 thymic carcinomas. We also examined p53 gene (exon 5-8) mutation in 18 thymic carcinomas by using polymerase chain reaction-single-strand conformation polymorphism methods and direct sequencing. Of the thymoma cases, only one invasive thymoma showed focal nuclear staining. Fourteen of the 19 thymic carcinomas (74%) showed nuclear staining. Point mutations of the p53 gene were recognized in only 2 of the 18 thymic carcinomas (11%). One was the mutation C to T transition in the first letter of codon 222 in exon 6, which results in the amino acid substitution from proline to serine. Another was a silent mutation. p53 protein accumulation is highly frequent in thymic carcinomas but not in thymomas, and gene mutation is uncommon in thymic carcinomas.
(キーワード): Adult / Aged / Aged, 80 and over / Female / Humans / Immunohistochemistry / Male / Middle Aged / Mutation / Nuclear Proteins / Proto-Oncogene Proteins / Proto-Oncogene Proteins c-mdm2 / Thymoma / Thymus Neoplasms / Tumor Suppressor Protein p53
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9374384; ● Search Scopus @ Elsevier (PMID): 9374384

(PubMed: 9374384) Kazuya Kondo, Tadashi Uyama, Masayuki Sumitomo, Keiji Takahashi, Suguru Kimura and Yasumasa Monden :
Invasive thymoma with endobronchial polypoid growth.,
Surgery Today, Vol.27, No.5, 466-468, 1997.

(要約): A rare case of invasive thymoma with endobronchial polypoid growth is presented. A 68-year-old woman presented with coughing and sputum. The chest X-ray and computed tomography (CT) findings demonstrated a large mass with a calcified lesion in the left hilar region. A bronchoscopic examination showed a polypoid tumor in the left B3b bronchus. The tumor was surgically resected and revealed a unique polypoid endobronchial extension. This tumor was pathologically diagnosed to be invasive thymoma.
(キーワード): Aged / Antineoplastic Combined Chemotherapy Protocols / Bronchial Neoplasms / Cisplatin / Cyclophosphamide / Doxorubicin / Female / Humans / Neoplasm Invasiveness / Polyps / Thymoma / Thymus Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9130355; ● Search Scopus @ Elsevier (PMID): 9130355

(PubMed: 9130355) 橋本一郎, 中西秀樹, 加藤昭二, 長江浩朗, 清家卓也, 荒瀬誠治, 近藤和也, 住友正幸, 門田康正, 長谷川匡 :
骨外性粘液型軟骨肉腫に対する遊離植皮術後に発症した肺塞栓の1例,
形成外科, Vol.39, No.2, 197-203, 1996年. Kazuya Kondo, H Tsuzuki, M Sasa, M Sumitomo, T Uyama and Yasumasa Monden :
A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients.,
Journal of Surgical Oncology, Vol.61, No.1, 20-26, 1996.

(要約): Mutations of the p53 tumor suppressor gene are frequent in lung cancers. It is suggested that p53 mutations are associated with smoking-induced lung carcinogenesis. We examined p53 mutations in 53 lung cancers by analyzing reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) to ascertain the association between p53 mutations and smoking. Twenty-five (47%) of 53 lung cancers carried p53 mutations. A discriminant analysis showed that the Brinkman index (0.156) and gender (0.140) significantly influenced p53 mutations. Furthermore, there was a dose-response relationship between the quantity of cigarettes consumed and the frequency of p53 mutations in lung cancer patients (P < 0.001). In patients with adenocarcinoma, the frequency of p53 mutations correlated with the amount of the tobacco smoked (P < 0.05). We suggest that the p53 gene is a target of particular carcinogen in tobacco smoke.
(キーワード): Adenocarcinoma / Adult / Aged / Aged, 80 and over / Base Sequence / Carcinoma, Squamous Cell / Female / Genes, p53 / Humans / Lung Neoplasms / Male / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Polymorphism, Single-Stranded Conformational / Smoking / Survival Rate
(出版サイトへのリンク): ● Publication site (DOI): 10.1002/(SICI)1096-9098(199601)61:1<20::AID-JSO6>3.0.CO;2-U
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8544455; ● Search Scopus @ Elsevier (PMID): 8544455; ● Search Scopus @ Elsevier (DOI): 10.1002/(SICI)1096-9098(199601)61:1<20::AID-JSO6>3.0.CO;2-U

(DOI: 10.1002/(SICI)1096-9098(199601)61:1<20::AID-JSO6>3.0.CO;2-U, PubMed: 8544455) Mitsunori Sasa, Kazuya Kondo, Kansei Komaki, Tadaoki Morimoto and Yasumasa Monden :
p53 alteration correlates with negative ER, negative PgR, and high histologic grade in breast cancer.,
Journal of Surgical Oncology, Vol.56, No.1, 46-50, 1994.

(要約): Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlation with (1) a negative ER status, (2) a negative PgR status, and (3) a high histologic grade (especially numerous mitotic figures) of the tumor. However, we found no correlation between p53 gene alteration and the lymph node status or clinical stage. Thus, p53 gene alteration in breast cancer may occur in highly malignant breast cancer other than advanced clinical stage cancer or node-positive cancer.
(キーワード): Adult / Aged / Base Sequence / Breast Neoplasms / Female / Genes, p53 / Humans / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Polymorphism, Genetic / Receptors, Estrogen / Receptors, Progesterone
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8176940; ● Search Scopus @ Elsevier (PMID): 8176940

(PubMed: 8176940) M Sasa, Kazuya Kondo, K Komaki, T Uyama, Tadaoki Morimoto and Yasumasa Monden :
Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan.,
Breast Cancer Research and Treatment, Vol.27, No.3, 247-252, 1993.

(要約): Sixty-five tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) method and sequencing analysis. In total, 16 samples (24.6%) showed p53 gene alteration. Sixteen of these alterations were evaluated by sequencing analysis, and 15 showed missense point mutations while one showed a 9-base pair deletion. In the 15 point mutations, G:C to A:T transitions constituted the majority (53%), and five tumors (33%) had a transition at the CpG site, which are mutational patterns not commonly found in breast tumors from Europe and America. On the other hand, there were no G:C to T:A transversions in our cases, which were frequently observed transversions in Europe and America. These p53 mutation patterns in breast cancer in Japan are not similar to those in Europe and America reported by Hollstein et al. and Coles et al.. These findings suggest that there are some differences between mechanisms of breast cancer in Japan and in Europe and America.
(キーワード): Adult / Aged / Base Sequence / Breast Neoplasms / Female / Genes, p53 / Humans / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8312582; ● Search Scopus @ Elsevier (PMID): 8312582

(PubMed: 8312582) Kazuya Kondo, Atsushi Umemoto, Shigeru Akimoto, Tadashi Uyama, Kenshi Hayashi, Yoshinari Ohnishi and Yasumasa Monden :
Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.,
Biochemical and Biophysical Research Communications, Vol.183, No.3, 1139-1146, 1992.

(要約): The reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) analysis and sequencing were used to examine p53 gene alterations in 18 surgical specimens of primary lung cancers obtained in Japan. Somatic mutations resulting in amino acid changes were found in eight of the 18 cases (44%). Seven missense mutations were located in amino acid-conserved domains or their vicinities (codons 110 to 307). Most mutations were found at G-C pairs, suggesting that specific carcinogens are involved in the etiology of lung cancer. The p53 mutations showed a significant association with a history of smoking (P = 0.0294). We suggest that the p53 mutations may be associated with smoking-induced lung carcinogenesis.
(キーワード): Adenocarcinoma / Base Sequence / Carcinoma / Genes, Tumor Suppressor / Humans / Japan / Lung Neoplasms / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Polymorphism, Restriction Fragment Length / Smoking / Tumor Suppressor Protein p53
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1348931; ● Search Scopus @ Elsevier (PMID): 1348931

(PubMed: 1348931) Kazuya Kondo, K Mukai, Y Sato, Y Matsuno, Y Shimosato and Y Monden :
An immunohistochemical study of thymic epithelial tumors. III. The distribution of interdigitating reticulum cells and S-100 beta-positive small lymphocytes.,
The American Journal of Surgical Pathology, Vol.14, No.12, 1139-1147, 1990.

(要約): We report an immunohistochemical study of the distribution and number of interdigitating reticulum cells (IDC) and S-100 beta-positive small lymphocytes (S-100 beta + lymphocytes) in 53 thymomas and 11 thymic carcinomas. All 53 thymomas showed the presence of IDC in the tumor parenchyma. In most cases of predominantly lymphocytic and mixed-type thymoma, IDC clustered in areas, that corresponded to locations that had medullary differentiation and contained accumulated mature lymphocytes. By contrast, in most of the predominantly epithelial-type thymomas, IDC were scattered rather than forming clusters. The distribution and number of IDC were correlation with the histological type of thymoma but not with invasiveness. In thymic carcinomas, IDC were scattered in tumor nests. In 47 of the 53 thymomas (89%), infiltrating S-100 beta + lymphocytes were readily recognized. The remaining six cases without S-100 beta + lymphocytes were noninvasive thymoma. We conclude that the degree of S-100 beta + lymphocyte infiltration is correlated with the stage of thymoma and may be a marker of thymoma malignancy.
(キーワード): Adult / Aged / Carcinoma / Dendritic Cells / Female / Humans / Immunohistochemistry / Lymphocytes / Male / Middle Aged / S100 Proteins / Thymoma / Thymus Neoplasms
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2252104; ● Search Scopus @ Elsevier (PMID): 2252104

(PubMed: 2252104) Kazuya Kondo, Masayuki Noguchi, Kiyoshi Mukai, Yoshihiro Matsuno, Yuichi Sato, Yukio Shimosato and Yasumasa Monden :
Transferrin receptor expression in adenocarcinoma of the lung as a histopathologic indicator of prognosis.,
Chest, Vol.97, No.6, 1367-1371, 1990.

(要約): Immunohistochemical reactivity with OKT9 (antitransferrin receptor) monoclonal antibody was studied in 58 surgically resected adenocarcinomas of the lung. The cell surface and cytoplasm of the tumor cells were stained in 44 cases (76 percent). The expression of the transferrin receptor (TrfR) in tumor cells was compared with histopathologic prognostic factors, such as TNM factors, degree of histologic differentiation, degree of nuclear atypia, and frequency of mitotic figures. The expression of TrfR showed significant correlation with the degree of histopathologic differentiation (p less than 0.025), degree of nuclear atypia (p less than 0.025), and frequency of mitotic figures (p less than 0.001). However, there was no definite correlation with TNM factors. These results indicate that the expression of the TrfR in pulmonary adenocarcinoma corresponds to the elevated proliferative activity of the tumor cells, and that immunohistochemical reactivity with OKT9 can be used as one of the histopathologic indicators of prognosis of pulmonary adenocarcinoma.
(キーワード): Adenocarcinoma / Antibodies, Monoclonal / Humans / Immunoenzyme Techniques / Lung / Lung Neoplasms / Mitotic Index / Prognosis / Receptors, Transferrin
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2189695; ● Search Scopus @ Elsevier (PMID): 2189695

(PubMed: 2189695)

MISC

吉田光輝, 先山正二, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
臨床と研究腎癌肺転移巣の組織学的異型度が画像診断に及ぼす影響,
胸部外科, Vol.66, No.11, 996-999, 2013年.

(キーワード): 肺転移 / 腎細胞癌 / 組織学的異型度 / lung metastasis / renal cell carcinoma / degree of histologic atypia
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24105116; ● CiNii @ 国立情報学研究所 (CRID): 1390282763058427648; ● Summary page in Scopus @ Elsevier: 2-s2.0-84892415509

(PubMed: 24105116, CiNii: 1390282763058427648, Elsevier: Scopus) 奥田紀久子, 中瀬勝則, 近藤和也, 谷洋江, 岩佐幸恵, 谷岡哲也 :
喫煙防止教育前後における高校生の喫煙に対する態度と意識の変化,
四国医学雑誌, Vol.68, No.5.6, 239-244, 2012年.

(要約): In order to prevent the smoking habit, it is important to start a smoking prevention education (SPE)earlier. Implementing educational intervention with appropriate timing and content is necessary during and after the high school years when a smoking habit is easily formed. The purpose of this research was to clarify high school students' attitudes and beliefs towards smoking before and after SPE and to examine how to provide optimal SPE in the future. The subjects were 680 high school students in the A prefecture. The SPE was implemented, their attitudes and beliefs towards smoking habit were measured using a scale of``belief and attitude towards smoking habits'', and its changes were assessed before and after the education and eight months later. The scores showed significant change in negative attitude toward smoking habit immediately after the SPE. However, the survey after eight months showed the SPE effects were not maintained except one item. Gender and the presence or absence of smokers in their family was involved in the continuation of the effects of SPE. It was suggested that it is necessary to have an appropriate intervention method to the subjects' characteristics and the optimal intervention timing should be discussed and an approach to reinforce the continuance of effects of SPE are required for the SPE in the future.
(キーワード): preventing smoking education / high-school students / effect of education / attitudes towards smoking habits
(徳島大学機関リポジトリ): ● Metadata: 110363
(文献検索サイトへのリンク): ● CiNii @ 国立情報学研究所 (CRID): 1050282812441817600

(徳島大学機関リポジトリ: 110363, CiNii: 1050282812441817600) Kazuya Kondo :
Invited commentary.,
The Annals of Thoracic Surgery, Vol.89, No.5, 1619, 2010.

(キーワード): Humans / Neoplasm Invasiveness / Phrenic Nerve / Respiratory Paralysis / Thymectomy / Thymoma / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.athoracsur.2010.02.071
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20417789; ● Search Scopus @ Elsevier (PMID): 20417789; ● Search Scopus @ Elsevier (DOI): 10.1016/j.athoracsur.2010.02.071

(DOI: 10.1016/j.athoracsur.2010.02.071, PubMed: 20417789) Koichiro Kenzaki, Yukiko Hirose, Masafumi Tamaki, Shoji Sakiyama, Kazuya Kondo, Teruo Matsuda and Yasumasa Monden :
Novel bronchofiberscopic catheter spray device allows effective anesthetic spray and sputum suctioning,
Respiratory Medicine, Vol.98, No.7, 606-610, 2004.

(要約): To evaluate how serum lidocaine concentrations (SLC) rise when lidocaine is administered by a Bronchofiberscopic Catheter Spray Device (BCSD), and to demonstrate the effect on the aspiration speed of a substitute for sputum when a catheter spray remains in the channel of the bronchofiberscope (BF). This is a prospective randomized clinical study. After lidocaine ultrasonic nebulizer, the BF was inserted orally. During the procedure patients received 4% lidocaine by two methods. In Group 1, 11 patients received lidocaine by bronchofiberscopic (BF) injection. In Group 2, 15 patients received lidocaine by spraying from the diameter 1.06 mm catheter through the BF channel. SLC were measured at 40 min from onset of nebulization. Separately, we examined how effectively sputum was aspirated through the BF channel with a catheter. Total lidocaine dose (TLD) is the total dose used for nebulization and for the BF injection or spray. The TLD for Groups 1 and 2 were 698.2+/-162.1 mg (mean+/-SD) and 498.7+/-103.8 mg, respectively (P = 0.03). The SLC for Groups 1 and 2 were 1.28+/-0.72 and 1.48+/-0.70 mg/l, respectively (P = 0.49). Using BCSD allows easier in administration of lidocaine and is not associated with a significant increase in SLC in comparison with BF injection. Although sputum aspiration using the BF inserted with our catheter was somewhat slow, we did not feel inconvenient so much. Compared to the conventional method, using BCSD may be preferable for patients and bronchoscopists.
(キーワード): Bronchofiberscopy / Catheter / Local anesthesia / Lidocaine / Spray
(出版サイトへのリンク): ● Publication site (DOI): 10.1016/j.rmed.2004.01.002
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15250225; ● Search Scopus @ Elsevier (PMID): 15250225; ● Search Scopus @ Elsevier (DOI): 10.1016/j.rmed.2004.01.002

(DOI: 10.1016/j.rmed.2004.01.002, PubMed: 15250225)

総説・解説

Kazuya Kondo :
Tumor-node metastasis staging system for thymic epithelial tumors.,
Journal of Thoracic Oncology, Vol.5, No.10 Suppl 4, S352-6, Oct. 2010.

(要約): This TNM staging system is an excellent predictor for the prognosis of thymic epithelial tumors including thymic carcinoma. The N and/or M factors influence the prognosis more than T factor. For the subclassification of the N and/or M factors, large-scale studies including the resectable and unresectable tumors are necessary.
(キーワード): Humans / Lymph Nodes / Lymphatic Metastasis / Neoplasm Staging / Neoplasms, Glandular and Epithelial / Prognosis / Thymoma / Thymus Neoplasms
(出版サイトへのリンク): ● Publication site (DOI): 10.1097/JTO.0b013e3181f20f3b
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20859132; ● Summary page in Scopus @ Elsevier: 2-s2.0-77957560975

(DOI: 10.1097/JTO.0b013e3181f20f3b, PubMed: 20859132, Elsevier: Scopus) Junji Ueno, Tomoya Murase, Kazuhide Yoneda, Tetsuya Tsujikawa, Shoji Sakiyama and Kazuya Kondo :
Three-dimensional imaging of thoracic diseases with multi-detector row CT,
The Journal of Medical Investigation : JMI, Vol.51, No.3,4, 163-170, Aug. 2004.

(要約): The benefits of multi-detector row CT (MDCT) relative to single-detector row helical CT are considerable. Multi-detector row CT allows shorter acquisition times, greater coverage, and superior image resolution. These factors substantially increase the diagnostic accuracy of the examination. Three-dimensional (3D) volume data from MDCT provides various unique applications on thoracic diseases. These includes isotropic viewings, use of multiplanar reformation (MPR), maximum and minimum intensity projections (MIP and minIP), and volume rendering performed from external and internal perspectives allowing the user to "fly around" and "fly through" the structures. Recent advances in 3D volume rendering put real-time, interactive virtual reality guidance of the procedures such as bronchoscopy and surgery into practice.
(キーワード): Cardiovascular Diseases / Humans / Image Processing, Computer-Assisted / Imaging, Three-Dimensional / Respiratory Tract Diseases / Thoracic Diseases / Thoracic Wall / Tomography, X-Ray Computed
(徳島大学機関リポジトリ): ● Metadata: 110737
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.51.163
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15460902; ● Search Scopus @ Elsevier (PMID): 15460902; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.51.163

(徳島大学機関リポジトリ: 110737, DOI: 10.2152/jmi.51.163, PubMed: 15460902)

講演・発表

Tamaki Otani, Hitoshi Ikushima, Yoshimi Bando, Kenmei Kuwahara, Hideki Otsuka, Kazuya Kondo and Hirokazu Miyoshi :
Efficacy of 18F-fluorothymidine and 18F-fluorodeoxyglucose Positron Emission Tomography in Determining a Radiotherapy Effect.,
Annual Congress of the European Association of Nuclear Medicine, Oct. 2021. K. Muguruma, Kazuya Kondo, R. Kishibuchi, Mitsuhiro Tsuboi, S. Soejima, B. Tegshee, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
DNA Methylation of MT1A and NPTX2 Genes Predict Malignant Behavior of Thymic Epithelial Tumors,
The IASLC 20th World Conference on Lung Cancer, Sep. 2019. S. Soejima, Kazuya Kondo, Mitsuhiro Tsuboi, R. Kishibuchi, K. Muguruma, B. Tegshee, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Mitsuteru Yoshida, Hiromitsu Takizawa, Akira Tangoku and N. Wusiman :
GAD1 Expression and Its Methylation Become Indicators of Malignant Behavior in Thymic Epithelial Tumor,
The IASLC 20th World Conference on Lung Cancer, Sep. 2019. Kazuya Kondo :
Breakthroughs in oncology medicine, genomics, research and practice.,
4th SPUP International Health Congress health Care Technology and Innovations in the 3rd Millennium, Dec. 2018. Hiromitsu Takizawa, Toru Sawada, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Autofluorescence Mode of Thoracoscope Improves Visceral Pleural Invasion Diagnosis in Non-Small Cell Lung Cancer,
19th World Conference on Lung Cancer, Sep. 2018. Naoya Kawakita, Hiromitsu Takizawa, Ali Eman, Mika Takashima, Daisuke Matsumoto, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
Cone-Beam CT Confirms the Status of Transbronchial Biopsy Under Virtual Bronchoscopic Navigation for Peripheral Lung Lesions,
19th World Conference on Lung Cancer, Sep. 2018. Hiromitsu Takizawa, Mika Takashima, Daisuke Matsumoto, Naoya Kawakita, Toru Sawada, Mitsuhiro Tsuboi, Hiroaki Toba, Mitsuteru Yoshida, Yukikiyo Kawakami, Kazuya Kondo and Akira Tangoku :
CT and PET/CT Parameters of Lepidic Predominant Pattern Lung Adenocarcinoma and Invasiveness on Pathology,
19th World Conference on Lung Cancer, Sep. 2018. Kazuya Kondo, Soejima Shiho, wusiman nuliamina, Kishibuchi Reina, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Toru Sawada, Hiroaki Toba, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
The expression of DNA methylation of GAD1 gene is an indicator of malignant behavior in thymic epithelial tumor,
19th World Conference on Lung Cancer, Sep. 2018. 澤田徹, Kazuya Kondo, Mitsuhiro Tsuboi, Naoya Kawakita, Koichiro Kajiura, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida, Hiromitsu Takizawa and Akira Tangoku :
FDG-PET/CT Might Be a Predictor for Residual Disease in Advanced NSCLC after Chemoradiotherapy,
17th World Conference on Lung Cancer, Dec. 2016. Naoya Kawakita, Hiroaki Toba, 澤田徹, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Mitsuteru Yoshida, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Stratification of pStage I Lung Adenocarcinoma by the Scoring System Based on Prognostic Factors,
17th World Conference on Lung Cancer, Dec. 2016. Mitsuhiro Tsuboi, Kazuya Kondo, Koichiro Kajiura, Hiromitsu Takizawa, 澤田徹, Naoya Kawakita, Hiroaki Toba, Yukikiyo Kawakami, Mitsuteru Yoshida and Akira Tangoku :
Promoter Hypermethylation of DNA Mismatch Repair Gene hMLH1 of Lung Cancer in Chromate-Exposed Workers,
17th World Conference on Lung Cancer, Dec. 2016. Koichiro Kajiura, Kazuya Kondo, 澤田徹, Naoya Kawakita, Mitsuhiro Tsuboi, Hiromitsu Takizawa and Akira Tangoku :
The Relationship of CDH3 Expression and DNA Methylation in Thymic Epitherial Tumors,
17th World Conference on Lung Cancer, Dec. 2016. Kazuya Kondo :
The Thymic Cancer Staging System,
17th World Conference on Lung Cancer, Dec. 2016. Kazuya Kondo :
Staging system of thymic epithelial tumor,
KASLC (The Korean Association for the Study of Lung Cancer) Fall Conference in conjunction with Korea-Japan Symposium, Nov. 2015. Tamaki Otani, Kazuya Kondo, Hiromitsu Takizawa, Koichiro Kajiura, Fujino Haruhiko and Hideki Otsuka :
Non-Invasive Assessment of Cisplatin and Erlotinib Efficacy in Lung Cancer by Monitoring an Orthotopic SCID Mouse Model with Computed Tomography,
16th World Conference on Lung Cancer, Sep. 2015. Koichiro Kajiura, Kazuya Kondo, 松本大資, 河北直也, Mitsuhiro Tsuboi, Hiroaki Toba, Yukikiyo Kawakami, Hiromitsu Takizawa, Shoji Sakiyama and Akira Tangoku :
DNA Methylation on Promotor Region of RASSF1 Gene in Thymic Neuroendocrine Tumor Is Higher than B3 Thymoma and Thymic Squamous Cell Carcinoma,
16th World Conference on Lung Cancer, Sep. 2015. Mitsuhiro Tsuboi, Hiromitsu Takizawa, Daisuke Matsumoto, Naoya Kawakita, Koichiro Kajiura, Hiroaki Toba, Yukikiyo Kawakami, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
The Correlation between Visceral Pleural Invasion in T1a Non-Small Lung Cancer and Lymph Node Metastasis,
16th World Conference on Lung Cancer, Sep. 2015. Kazuya Kondo, Tomoko Kawanishi, Mariko Shiraishi, Chikako Takai, Yuki Morimoto, Tamaki Otani, Mitsuhiro Tsuboi, Koichiro Kajiura, Hiromitsu Takizawa, Gokei Kawakami, Hiroaki Toba, Shoji Sakiyama and Akira Tangoku :
The MRE11/RAD50/NBS1 Complex Was Impaired in Lung Cancer from Chromate-Exposed Workers,
16th World Conference on Lung Cancer, Sep. 2015. Hiromitsu Takizawa, Kazuya Kondo, Mitsuhiro Tsuboi, Koichiro Kajiura, Tamaki Otani, Hiroaki Toba, Yukikiyo Kawakami, Shoji Sakiyama and Akira Tangoku :
Mini OralComputed Tomography Lymphography by Transbronchial Injection of Iopamidol for Preoperative,
16th World Conference on Lung Cancer, Sep. 2015. Tamaki Otani, Hideki Otsuka, Kazuya Kondo, Hiromitsu Takizawa and Nagata Motoi :
Utility of respiratory-gated PET/CT in the chronological evaluation of an orthotopic lung cancer transplantation mouse model,
Annual Congress of the European Association of Nuclear Medicine, Oct. 2014. Takae Bando, Kazuya Kondo, Satou Hiromi and Yoshie Imai :
EVALUATION OF EDUCATIONAL PROGRAM USING SURGERY VIDEO FOR THE NURSES WORKING IN THE OPERATING ROOM,
4th ASIORNA CONFERENCE 2014, 39, Fukuoka, Oct. 2014. Mitsuteru Yoshida, Shoji Sakiyama, 日野弘之, 高嶋美佳, Mitsuhiro Tsuboi, Koichiro Kajiura, Hiroaki Toba, Yasushi Nakagawa, Yukikiyo Kawakami, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Anatomical Anomaly Cases Of General Thoracic Surgery,
American Thoracic Society International Conference2014, San Diego, May 2014. Shoji Sakiyama, Mitsuteru Yoshida, Yukikiyo Kawakami, Koichiro Kenzaki, Mitsuhiro Tsuboi, Koichiro Kajiura, Yasushi Nakagawa, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Glucocorticoid Administration Facilitates The Differentiation Of Rat Fetal Lung Fragments Into Adult Rat Lung Parenchyma,
American Thoracic Society International Conference2014, San Diego, California, May 2014. Yoshito Yamada, Ichiro Yoshino, Yoshitaka Fujii, Hisao Asamura, Kazuo Yoshida, Hiroshi Date, Kanji Nagai, Kohei Yokoi, Jun Nakajima, Shinichiro Miyoshi, Kazuya Kondo and Meinoshin Okumura :
Surgical Outcome of Patients with Stage III Thymoma in the Japanese Nationwide Database,
15th World Conference on Lung Cancer, Oct. 2013. Meinoshin Okumura, Yoshitaka Fujii, Ichiro Yoshino, Hisao Asamura, Kazuo Yoshida, Hiroshi Date, Kanji Nagai, Kohei Yokoi, Jun Nakajima, Shinichiro Miyoshi and Kazuya Kondo :
Outcome of surgical treatment for thymic epithelial tumors based on the nationwide retrospective database of 3033 patients in Japan,
15th World Conference on Lung Cancer, Oct. 2013. Yasushi Nakagawa, Kazuya Kondo, Jun Nakajima, Meinoshin Okumura, Ichiro Yoshino, Yoshitaka Fujii, Hisao Asamura, Kazuo Yoshida, Hiroshi Date, Kanji Nagai, Kohei Yokoi, Shinichiro Miyoshi, Shoji Sakiyama and Akira Tangoku :
Analysis of lymphatic metastases of thymic epithelial tumors on Japanese database,
15th World Conference on Lung Cancer, Oct. 2013. Koichiro Kajiura, Shoji Sakiyama, Hiromitsu Takizawa, Yasushi Nakagawa, Kazuya Kondo and Akira Tangoku :
Prophylactic landiolol administration can prevent atrial fibrillation after lobectomy?,
15th World Conference on Lung Cancer, Oct. 2013. Hiromitsu Takizawa, Kazuya Kondo, Tamaki Otani, Ali M. Mohammed, Hideki Otsuka, Mitsuhiro Tsuboi, Koichiro Kajiura, Yasushi Nakagawa, Yukikiyo Kawakami, Mitsuteru Yoshida, Shoji Sakiyama and Akira Tangoku :
Positron-emission tomography-computed tomography with the glucose analogue [18F] fluorodeoxyglucose in orthotopic implantation SCID mouse model of lung cancer,
15th World Conference on Lung Cancer, Oct. 2013. Mitsuhiro Tsuboi, Hiromitsu Takizawa, Kazuya Kondo, Hisashi Ishikura, Suguru Kimura, Koichiro Kajiura, Yasushi Nakagawa, Yukikiyo Kawakami, Mitsuteru Yoshida, Shoji Sakiyama and Akira Tangoku :
A feasibility study of postoperative adjuvant chemotherapy with fluoropyrimidine S-1 in patients with stage II-IIIA non-small cell lung cance,
15th World Conference on Lung Cancer, Oct. 2013. Kikuko Okuda, Yoshiko Gohgi, Chieko Fujii, Yukie Iwasa, Hiroe Tani, Kazuya Kondo and Tetsuya Tanioka :
Relationship between the Parent's Smoking Habit and the Knowledge/Consciousness after Smoke Prevention Education Targeted at Elementary School Students,
Proceedings of the Sixth International Conference on Information(Info13), 59-66, May 2013. Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, Koichiro Kajiura, Mayumi Ikeda, Takako Furukawa, Takeshi Nishino, Yasushi Nakagawa, Mitsuteru Yoshida, Yukikiyo Kawakami, Shoji Sakiyama and Akira Tangoku :
PREOPERATIVE AND INTRAOPERATIVE IDENTIFICATION OF SENTINEL NODES IN PATIENTS,
THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC, Apr. 2013. Takai C., Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
Microarray analysis for CD classification of thymic epithelial cell subpopulations,
3rd International Thymic Malignancy Interest Group Annual Meeting, Nov. 2012. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Nomura Yoshiko, Yousuke Takahama and Ryuji Kaji :
Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia,
11th International congress of neuroimmunology, Nov. 2012. Hitoshi Ikushima, Kazuya Kondo and Youichi Otomi :
Treatmet effect of eoadjuvat chemoradiatio therapy for osmall cell lug cacer evaluated by multi-modality imaging and histopathological analyses,
ASTRO 54, Sep. 2012. Yoshie Imai, Misako Nakagawa, Chiemi Onishi, Keiko Mori, Takae Bando, Kazuya Kondo and Akira Tangoku :
Symptoms and knowledge of lymphedema among postoperative breast cancer patients without lymphedema,
Prague, Sep. 2012. Takae Bando, Chiemi Onishi, 山田和代, Kazuya Kondo, Yoshie Imai, Keiko Mori, Shoji Sakiyama and Hiromitsu Takizawa :
Acute sholder symptoms and related factors in patients undergoing lung cancer surgery,
Prague, Sep. 2012. Yoshihiro Tanaka, Hitoshi Ikushima, Hiroshi Maezawa and Kazuya Kondo :
Usefulness of diagnostic imaging in neoadjuvant chemoradiation therapy for non-small cell lung cancer,
ESTRO 31, May 2012. Y. Fujita, Kazuya Kondo, A.H.K. Ali, T. Namura, Y. Senba, Y. Oiwa, C. Takai, Hiromitsu Takizawa, Yasushi Nakagawa, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Polymorphisms in x-ray repair cross-complementing group 1 (XRCC1) base excision repair gene and lung cancer risk in industrial workers with chromate exposure,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. A.H.K. Ali, Hiromitsu Takizawa, Kazuya Kondo, Yasushi Nakagawa, Hiroaki Toba, N. Khasag, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Follow- up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. M. Takashima, Hiromitsu Takizawa, K. Kajiura, K. Uyama, Hiroaki Toba, Yasushi Nakagawa, Yukikiyo Kawakami, Koichiro Kenzaki, Shoji Sakiyama, Kazuya Kondo and Akira Tangoku :
Comparison of two different EGFR gene mutation tests for resected lung adenocarcinoma,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. K. Kajiura, Hiroaki Toba, Shoji Sakiyama, M. Takashima, K. Uyama, Yasushi Nakagawa, Hiromitsu Takizawa, Yukikiyo Kawakami, Koichiro Kenzaki, Kazuya Kondo and Akira Tangoku :
Experience of TBLB using thin bronchoscopy with VBN,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. H. Matsuoka, Kazuya Kondo, Hiromitsu Takizawa, H. Fujino, K. Uyama, Hiroaki Toba, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Comprehensive evaluation of the responded genes by the administration of anti-tumor drug, S-1 using low,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. Hiromitsu Takizawa, Kazuya Kondo, Hiroaki Toba, K. Kajiura, M. Takashima, K. Uyama, Yasushi Nakagawa, Yukikiyo Kawakami, Koichiro Kenzaki, Shoji Sakiyama and Akira Tangoku :
Computed tomography lymphography by transbronchial injection of a water-soluble extracellular CT,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. Kazuya Kondo :
Thymoma,
14TH WORLD CONFERENCE ON LUNG CANCER, Jul. 2011. Kazuya Kondo :
WorkshopPrognostic Factors Morning LecturesJapanese experience,
International Thymic Malignancy Interest Group(ITMIG), Nov. 2010. Kikuko Okuda, Kazuya Kondo and Chieko Fujii :
The effectivness education program of prevention children from smoking cigarette in Japan,
6th International Conference of Health Behavioral Science, 94, Kuala Lumpur, Sep. 2010. Khalil Hamed Abdellah, Hiromitsu Takizawa, Kazuya Kondo, Matsuoka Hisashi, Hiroaki Toba, Yasushi Nakagawa, Koichiro Kenzaki, Shoji Sakiyama, Kakiuchi Soji, Saburo Sone and Akira Tangoku :
In vitro and in vivo photodynamic diagnosis using 5-aminolevulinic acid in malignant mesothelioma,
The 10th International Conference of the International Mesothelioma Interest Group, Aug. 2010. Aki Takahashi, Takahiro Yoshida, Takae Bando, Yoshie Imai, Takeshi Nishino, Seiya Inoue, Akira Tangoku and Kazuya Kondo :
Quality of Life and Psycholugical Status ofPatients with Esophageal Cancer Who Underwent Minimal Invasive Surgery,
2nd Technological Competrncy as Caring inthe Health Sciences 2018, 111, Aug. 2008. Tadashi Kondo, Junji Ueno, Kazuya Kondo and Abhijit S. Pandya :
An application of self-selecting algorithm for optimum neural network architecture to medical image recognition,
Proceeding of the 44th SICE annual conference, 1657-1661, Aug. 2005.

(キーワード): ニューラルネットワーク (neural network) / 医療情報学 (medical infomatics)

Tadashi Kondo, Junji Ueno, Kazuya Kondo and Abhijit S. Pandya :
An algorithm for self-selecting optimum neural network architecture,
Proceeding of the 44th SICE annual conference, 1645-1650, Aug. 2005.

(キーワード): ニューラルネットワーク (neural network)

Takanori Miyoshi, Kazuya Kondo, Hiromitsu Takizawa, Kouichirou Kenzaki, Haruhiko Fujino, Shoji Sakiyama and Akira Tangoku :
P-171 Fluoroscopy-assisted thoracoscopic resection of pulmonarynodules after computed tomography-guided bronchoscopic metallic coil marking using virtual bronchoscopy navigation,
Lung Cancer, Vol.49, No.supplement2, s160, Feb. 2005. 桃田幸弘, 里村一人, 武知正晃, 工藤景子, 徳山麗子, 山崎泰文, 小柴邦彦, 近藤和也, 長山勝 :
縦隔膿瘍を発症した下顎智歯周囲炎の1例,
第35回日本口腔外科学会・中四国地方会, 河北直也, 細川暉雄, 竹内大平, 住友弘幸, 坂本晋一, 宮本直輝, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
Cone-beam CTガイド下極細径気管支鏡下生検における画像融合∼Augmented fluoroscopyの可能性∼,
第47回日本呼吸器内視鏡学会学術集会, 2024年6月. 坂本晋一, 滝沢宏光, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 森下敦司, 河北直也, 鳥羽博明, 近藤和也 :
当院における複雑区域切除への取り組み,
第47回日本呼吸器内視鏡学会学術集会, 2024年6月. 竹内大平, 鳥羽博明, 細川暉雄, 住友弘幸, 坂本晋一, 宮本直輝, 森下敦司, 河北直也, 近藤和也, 滝沢宏光 :
右上葉切除後中葉無気肺の臨床的特徴と転帰の検討,
第41回日本呼吸器外科学会学術集会, 2024年5月. 河北直也, 細川暉雄, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
遷延性肺瘻が肺癌の術後予後に与える影響,
第41回日本呼吸器外科学会学術集会, 2024年5月. 住友弘幸, 河北直也, 細川暉雄, 竹内大平, 坂本晋一, 宮本直輝, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
術前肺動脈径は肺癌術後の予後因子となり得る∼308例における検討∼,
第41回日本呼吸器外科学会学術集会, 2024年5月. 坂本晋一, 河北直也, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
腎細胞癌肺転移に対する外科手術の役割,
第41回日本呼吸器外科学会学術集会, 2024年5月. 宮本直輝, 細川暉雄, 竹内大平, 住友弘幸, 坂本晋一, 森下敦司, 河北直也, 近藤和也, 鳥羽博明, 滝沢宏光 :
Checkmate816試験登場後の当院における肺癌術前治療の変遷と現在の治療戦略,
第41回日本呼吸器外科学会学術集会, 2024年5月. 竹内大平, 滝沢宏光, 細川暉雄, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 河北直也, 鳥羽博明, 近藤和也 :
肺転移をきたしたA型胸腺腫の3例,
第43回日本胸腺研究会, 2024年2月. 竹内大平, 滝沢宏光, 細川暉雄, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 河北直也, 鳥羽博明, 近藤和也 :
ロボット支援手術が完全切除に有用であったIgG4関連後縦隔腫瘍の1例,
第85回日本臨床外科学会総会, 2023年11月. 板東孝枝, 近藤和也, 植地日菜子, 荒尾心喜, 尾形京香, 髙橋亜希, 今井芳枝, 井上勇太, 森裕香, 滝沢宏光 :
肺がん患者の術前のレジリエンス，心理的適応および健康関連QOL(第1報),
第64回日本肺癌学会学術集会, 2023年11月. Munkhjargal Batkhishig, Kazuya Kondo, Soejima Shiho, Tegshee Bilguun, Naoya Kawakita, Hiroaki Toba and Hiromitsu Takizawa :
Prognostic significance of PEAR1 expression in lung adenocarcinoma,
第64回日本肺癌学会学術集会, Nov. 2023. 森下敦司, 河北直也, 細川暉雄, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 鳥羽博明, 近藤和也, 滝沢宏光 :
Invasive mucinous adenocarcinomaにおける術前経気管支生検が及ぼす予後への影響,
第64回日本肺癌学会学術集会, 2023年11月. 宮本直輝, 吉田光輝, 細川暉雄, 竹内大平, 髙杉遥, 住友弘幸, 坂本晋一, 森下敦司, 河北直也, 近藤和也, 鳥羽博明, 滝沢宏光 :
アルギニンおよびシトルリンは免疫治療の補助薬となり得るか,
第64回日本肺癌学会学術集会, 2023年11月. 住友弘幸, 鳥羽博明, 細川暉雄, 竹内大平, 髙杉遥, 坂本晋一, 宮本直輝, 森下敦司, 河北直也, 近藤和也, 滝沢宏光 :
小型末梢肺病変に対する気管支鏡下コイルマーキング法の現状,
第64回日本肺癌学会学術集会, 2023年11月. 河北直也, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 近藤和也, 鳥羽博明, 滝沢宏光 :
精密な生検を目指したCone-beam CTガイド下極細径気管支鏡下生検∼Augmented Fluoroscopyで見える化する∼,
第64回日本肺癌学会学術集会, 2023年11月. 張林婉, 近藤和也, 板東孝枝, 髙橋亜希, 今井芳枝, 髙嶋美佳, 坂本晋一, 宮本直輝, 河北直也, 川上行奎, 吉田光輝, 鳥羽博明, 滝沢宏光 :
高齢者機能評価を用いた癌患者の治療方針の決定(第二報),
第64回日本肺癌学会学術集会, 2023年11月. 坂本晋一, 河北直也, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
予後因子に基づいた間質性肺炎合併肺癌に対する治療戦略,
第76回日本胸部外科学会定期学術集会, 2023年10月. 竹内大平, 河北直也, 細川暉雄, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
早期肺腺癌における炎症マーカーと予後に関する検討,
第76回日本胸部外科学会定期学術集会, 2023年10月. 住友弘幸, 鳥羽博明, 細川暉雄, 竹内大平, 坂本晋一, 宮本直輝, 森下敦司, 河北直也, 近藤和也, 滝沢宏光 :
ICG蛍光ガイド下に胸腔鏡下肺区域切除術を施行した肝細胞癌肺転移の1例,
日本蛍光ガイド手術研究会第6回学術集会, 2023年9月. 滝沢宏光, 細川暉雄, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 森下敦司, 河北直也, 鳥羽博明, 近藤和也 :
肺切除におけるICG蛍光による術中気管支動脈可視化の意義,
日本蛍光ガイド手術研究会第6回学術集会, 2023年9月. 竹内大平, 河北直也, 細川暉雄, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
術前に診断が困難であったアスペルギローマ合併肺癌の1例,
第98回中国四国外科学会総会/第28回中国四国内視鏡外科研究会, 2023年8月. 坂本晋一, 滝沢宏光, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 森下敦司, 河北直也, 鳥羽博明, 近藤和也 :
当院における複雑区域切除への取り組み,
第98回中国四国外科学会総会/第28回中国四国内視鏡外科研究会, 2023年8月. 坂本晋一, 滝沢宏光, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 河北直也, 鳥羽博明, 近藤和也 :
右下葉切除後に残存中葉切除を施行した一例,
第61回日本肺癌学会中国四国支部会, 2023年7月. 髙嶋美佳, 鳥羽博明, 井﨑富由実, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
感染を背景とした肺葉内の仮性動脈瘤に対し肺葉切除で救命した1例,
第40回日本呼吸器外科学会学術集会, 2023年7月. 井﨑富由実, 鳥羽博明, 竹内大平, 住友弘幸, 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 近藤和也, 滝沢宏光 :
対照的な術後経過をたどった胸管嚢胞の2切除例,
第40回日本呼吸器外科学会学術集会, 2023年7月. 坂本晋一, 鳥羽博明, 滝沢宏光, 井﨑富由実, 竹内大平, 住友弘幸, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 鶴尾吉宏, 音井威重 :
U-40呼吸器外科医が高難度手術手技を習得するための取り組み,
第40回日本呼吸器外科学会学術集会, 2023年7月. 住友弘幸, 河北直也, 井﨑富由実, 竹内大平, 坂本晋一, 宮本直輝, 髙嶋美佳, 川上行奎, 鳥羽博明, 近藤和也, 滝沢宏光 :
術前肺動脈径は肺癌術後の予後因子となり得る,
第40回日本呼吸器外科学会学術集会, 2023年7月. 宮本直輝, 吉田光輝, 井﨑富由実, 竹内大平, 住友弘幸, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 鳥羽博明, 滝沢宏光 :
アルギニン+シトルリンはPD-1阻害薬による抗腫瘍効果を増強する,
第40回日本呼吸器外科学会学術集会, 2023年7月. 鳥羽博明, 住友弘幸, 井﨑富由実, 竹内大平, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 近藤和也, 滝沢宏光 :
大きな縦隔腫瘍に対する気縦隔を用いた縦隔鏡アプローチ∼食道外科医との合同手術,
第40回日本呼吸器外科学会学術集会, 2023年7月. 河北直也, 鳥羽博明, 井﨑富由実, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
遷延性肺瘻のリスクスコアに基づく治療介入決定はドレーン留置期間を短縮させる,
第40回日本呼吸器外科学会学術集会, 2023年7月. 坂本晋一, 井﨑富由実, 竹内大平, 住友弘幸, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 鳥羽博明, 近藤和也, 滝沢宏光 :
左下葉肺癌に対しExtended sleeve lobectomy type Cを行った一例,
第46回日本呼吸器内視鏡学会学術集会, 2023年6月. 髙嶋美佳, 鳥羽博明, 井﨑富由実, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
進行肺癌の気道狭窄に対する気道ステント留置例の検討,
第46回日本呼吸器内視鏡学会学術集会, 2023年6月. 鳥羽博明, 河北直也, 住友弘幸, 坂本晋一, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
小型末梢肺病変を正確に診断するためのCone-beam CTの意義,
第46回日本呼吸器内視鏡学会学術集会, 2023年6月. 滝沢宏光, 細川暉雄, 井﨑富由実, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 森下敦司, 髙嶋美佳, 河北直也, 鳥羽博明, 近藤和也 :
Cone-beam CTガイド下金属コイルマーキングによる術中小型肺病変同定,
第46回日本呼吸器内視鏡学会学術集会, 2023年6月. 河北直也, 井﨑富由実, 竹内大平, 住友弘幸, 宮本直輝, 坂本晋一, 髙嶋美佳, 川上行奎, 近藤和也, 鳥羽博明, 滝沢宏光 :
Cone-beam CTガイド下極細径気管支鏡下生検におけるチャネル径の違いがもたらす意義,
第46回日本呼吸器内視鏡学会学術集会, 2023年6月. Yoshie Imai, Yoshie Murakami, Yuko Takeda, Yuko Kawasaki, Megumi Kishino, Yuka Mori, Megumi Kageyama, Tomoka Sakamoto, Takae Bando and Kazuya Kondo :
Process of parenting a child with retinoblastoma while guiding him or her toward disease acceptance,
Shikoku Acta Medica, Vol.79, No.1.2, 91-102, Jun. 2023.

(出版サイトへのリンク): ● Publication site (DOI): 10.57444/shikokuactamedica.79.1.2_91
(文献検索サイトへのリンク): ● Search Scopus @ Elsevier (DOI): 10.57444/shikokuactamedica.79.1.2_91

(DOI: 10.57444/shikokuactamedica.79.1.2_91) 宮本直輝, 井﨑富由実, 竹内大平, 住友弘幸, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 鳥羽博明, 滝沢宏光 :
モバイルCアーム3D画像と金属コイルマーキングによる術中小型肺病変同定,
第123回日本外科学会定期学術集会, 2023年4月. 河北直也, 鳥羽博明, 坂本晋一, 井﨑富由実, 竹内大平, 住友弘幸, 宮本直輝, 青山万理子, 髙嶋美佳, 松本大資, 井上聖也, 川上行奎, 近藤和也, 滝沢宏光 :
マウスiPS細胞由来の気管支肺胞幹細胞を用いた気道上皮再生,
第123回日本外科学会定期学術集会, 2023年4月. 宮本直輝, 近藤和也, 井﨑富由実, 竹内大平, 住友弘幸, 坂本晋一, 青山万理子, 髙嶋美佳, 河北直也, 川上行奎, 鳥羽博明, 滝沢宏光 :
Nivolumab投与後irAEとして浮腫，体重増加を認めた1例,
第20回日本臨床腫瘍学会学術集会, 2023年3月. 鳥羽博明, 坂本晋一, 住友弘幸, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
進行再発胸腺癌に対するレンバチニブの使用経験,
第42回日本胸腺研究会, 2023年2月. 張林婉, 近藤和也, 板東孝枝, 髙橋亜希, 今井芳枝, 髙嶋美佳, 坂本晋一, 宮本直輝, 河北直也, 川上行奎, 吉田光輝, 鳥羽博明, 滝沢宏光 :
高齢者肺癌患者における高齢者機能評価を用いた外科治療の適応の検討,
第63回日本肺癌学会学術集会, 2022年12月. Munkhjargal Batkhishig, Kazuya Kondo, 副島志帆, Tegshee Bilguun, Mitsuhiro Tsuboi, Koichiro Kajiura, Yukikiyo Kawakami, Naoya Kawakita, Hiroaki Toba, Mitsuteru Yoshida and Hiromitsu Takizawa :
ZNF577 functions as a tumor suppressor gene in lung adenocarcinoma,
第63回日本肺癌学会学術集会, Dec. 2022. 近藤和也, 副島志帆, Batkhishig Munkhjargal, 川上行奎, 河北直也, 鳥羽博明, 滝沢宏光 :
胸腺上皮性腫瘍におけるepigeneticな異常,
第63回日本肺癌学会学術集会, 2022年12月. 坂本晋一, 河北直也, 宮本直輝, 髙嶋美佳, 川上行奎, 鳥羽博明, 近藤和也, 滝沢宏光 :
臨床病期Ⅰ期の間質性肺疾患合併肺癌の検討,
第84回日本臨床外科学会総会, 2022年11月. 鳥羽博明, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
小型末梢肺病変に対する単孔式胸腔鏡下肺部分切除∼全身麻酔下にHybrid手術室で，コイルと色素を併用した気管支鏡下マーキング法を用いて,
第84回日本臨床外科学会総会, 2022年11月. 鳥羽博明, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
小型末梢肺病変に対する気管支鏡下コイルマーキングを用いたimage-guided VATS,
第75回日本胸部外科学会定期学術集会, 2022年10月. 宮本直輝, 近藤和也, 井﨑富由実, 竹内大平, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 鳥羽博明, 滝沢宏光 :
当院で経験したmicronodular thymic tumorの検討,
第97回中国四国外科学会総会/第27回中国四国内視鏡外科研究会, 2022年9月. 坂本晋一, 河北直也, 鳥羽博明, 宮本直輝, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
Endobronchial Watanabe Spigotを用いて喀血を制御し得た3例,
第45回日本呼吸器内視鏡学会学術集会, 2022年5月. 髙嶋美佳, 鳥羽博明, 坂本晋一, 宮本直輝, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
悪性気道狭窄に対する気道ステント留置例の検討,
第45回日本呼吸器内視鏡学会学術集会, 2022年5月. 鳥羽博明, 西野豪志, 河北直也, 坂本晋一, 宮本直輝, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
コンベックスEBUSは局所進行食道癌の気管・気管支浸潤の診断に有用である,
第45回日本呼吸器内視鏡学会学術集会, 2022年5月. 河北直也, 滝沢宏光, 宮本直輝, 坂本晋一, 髙嶋美佳, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也 :
末梢肺病変に対するCone-beam CT併用EBUS-UT法の導入,
第45回日本呼吸器内視鏡学会学術集会, 2022年5月. 髙嶋美佳, 鳥羽博明, 坂本晋一, 宮本直輝, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光 :
気管支断端補強，肺瘻修復に遊離心膜脂肪織を使用した症例の臨床的検討,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 鳥羽博明, 監﨑孝一郎, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 近藤和也, 滝沢宏光 :
未確診肺病変に対するRATS∼特にステイプラ使用本数に着目して,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 滝沢宏光, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 鳥羽博明, 近藤和也 :
肺癌手術における気管支動脈先行処理,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 鳥羽博明, 近藤和也, 滝沢宏光 :
コロナワクチン接種後に手術を行い，術後感染性合併症を契機にIgA血管炎を併発した2例,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 河北直也, 鳥羽博明, 宮本直輝, 坂本晋一, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
pStageⅠ肺腺癌の最適な個別化治療に向けて,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 吉田光輝, 大石久, Mckee D Trevor, Guana Zehong, Liu Mingyao, 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也 :
マウス肺移植後の慢性拒絶反応におけるAI評価の経験,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 坂本晋一, 河北直也, 鳥羽博明, 宮本直輝, 髙嶋美佳, 川上行奎, 近藤和也, 滝沢宏光 :
ILD-GAP indexを用いた間質性肺炎合併肺癌の治療戦略-予後因子に基づく層別化治療-,
第39回日本呼吸器外科学会学術集会(ハイブリッド開催), 2022年5月. 吉田光輝, 近藤和也, 北市隆, 西庄俊彦, 出水祐介, 尾矢剛志, 宮本直輝, 川上行奎, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 滝沢宏光 :
浸潤性縦隔腫瘍にいかに立ち向かうか-希少腫瘍の治療への挑戦-,
第122回日本外科学会定期学術集会(ハイブリッド開催), 2022年4月. 鳥羽博明, 西野豪志, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光 :
コンベックスEBUSが治療前後の気管膜様部浸潤の診断に有用であった局所進行食道癌の1切除例,
第30回日本呼吸器内視鏡学会中国四国支部会, 2021年12月. 髙嶋美佳, 鳥羽博明, 柿内聡司, 坂本晋一, 宮本直輝, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光 :
気管瘻を伴った進行肺癌による気道狭窄に対し気道ステント留置により長期にわたり良好なQOLを維持できた1例,
第30回日本呼吸器内視鏡学会中国四国支部会, 2021年12月. 河北直也, 滝沢宏光, 宮本直輝, 坂本晋一, 髙嶋美佳, 吉田光輝, 川上行奎, 近藤和也 :
長期金属ステント留置に伴う狭窄に対し，複数回のインターベンションを要した1例,
第30回日本呼吸器内視鏡学会中国四国支部会, 2021年12月. 副島志帆, 近藤和也, 坪井光弘, Bilguun Tegshee, 六車京香, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
肺腺癌におけるPEAR1発現の臨床的意義,
第62回日本肺癌学会学術集会, 2021年11月. 張林婉, 近藤和也, 板東孝枝, 今井芳枝, 髙橋亜希, 荒堀広美, 姚人尹, 孫楽キ, 滝沢宏光, 川上行奎, 吉田光輝, 鳥羽博明, 坪井光弘, 丹黒章 :
肺癌患者の周術期における息苦しさの評価,
第62回日本肺癌学会学術集会, 2021年11月. 吉田光輝, 近藤和也, 湯浅将生, 宮本直輝, 川上行奎, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 滝沢宏光 :
CT画像から胸腺腫の手術を議論できるか(石灰化と残存脂肪組織の三次元解析),
第62回日本肺癌学会学術集会, 2021年11月. 吉田光輝, 宮本直輝, 川上行奎, 近藤和也, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 滝沢宏光 :
難治性肺瘻に対する適切な治療戦略は決定できるか,
第74回日本胸部外科学会定期学術集会, 2021年10月. 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光 :
血中CA19-9が異常高値を示した成熟縦隔奇形種の1切除例,
第96回中国四国外科学会総会・第26回中国四国内視鏡外科研究会, 2021年9月. 坂本晋一, 滝沢宏光, 宮本直輝, 髙嶋美佳, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也 :
FDG-PET/CT画像を元に金属コイルマーキングを行い診断した間質性肺炎合併肺癌の一例,
第59回日本肺癌学会中国・四国支部学術集会, 2021年8月. 坂本晋一, 滝沢宏光, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
左B1+2転位気管支とV1+2の走行異常を認める左下葉肺癌の一切除例,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 松本大資, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
コイルと色素を併用した気管支鏡下マーキング法による，触知困難小型病変に対する単孔式胸腔鏡下肺部分切除,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 髙嶋美佳, 鳥羽博明, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
進行食道癌による気道のEmergencyに対する気道ステント留置例の検討,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 滝沢宏光, 河北直也, 庄野隆志, 南城和正, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
当科におけるCone-beam CT vs EBUS-GSガイド下経気管支生検による原発性肺癌診断の成績比較,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 河北直也, 滝沢宏光, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
原発性肺癌診断におけるCone-beam CT vs CTガイド下気管支鏡下生検,
第44回日本呼吸器内視鏡学会学術集会(ハイブリッド開催), 2021年6月. 今井芳枝, 阿部彰子, 宮本容子, 吉田友紀子, 板東孝枝, 髙橋亜希, 近藤和也 :
HBOCの乳がん罹患者がリスク低減卵管卵巣摘出術を受けた後の思い,
第27回日本遺伝性腫瘍学会学術集会, 2021年6月. 山本清成, 河北直也, 鳥羽博明, 南城和正, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
pStageⅠ肺腺癌におけるVolume doubling timeとSUVmax，優位組織亜型の関係,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 鳥羽博明, 河北直也, 髙嶋美佳, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
右B2転位気管支・V2破格・上下葉間分葉不全を伴う右下葉肺癌症例に対するRATS,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 庄野隆志, 滝沢宏光, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 吉田光輝, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
網膜芽細胞腫治療後に後縦隔に発生した平滑筋肉腫の一例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肺癌手術におけるICG蛍光を用いた気管支動脈可視化の意義,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 宮本直輝, 近藤和也, 南城和正, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
当院で経験したmicronodular thymic tumorの3例,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 髙嶋美佳, 鳥羽博明, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
悪性気道狭窄に対する気道ステント留置例の検討,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 河北直也, 鳥羽博明, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
浸潤径・SUVmaxで簡便にpStageⅠ肺腺癌の予後を層別化できる,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 坂本晋一, 河北直也, 鳥羽博明, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
間質性肺炎合併肺癌に対する予後予測因子の検討,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 松本大資, 鳥羽博明, 坂本晋一, 髙嶋美佳, 河北直也, 庄野隆志, 南城和正, 牧秀則, 山本清成, 宮本直輝, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
ラット胎仔肺移植による肺再生へのアプローチ,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 吉田光輝, 近藤和也, 湯浅将生, 宮本直輝, 川上行奎, 山本清成, 南城和正, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 滝沢宏光, 丹黒章 :
CT画像から胸腺の手術を考える,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 吉田光輝, 大石久, 宮本直輝, 近藤和也, 川上行奎, 南城和正, 山本清成, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 滝沢宏光, 丹黒章 :
トランスレーショナルリサーチに必ず必要な外科技術-呼吸器外科から創薬への社会貢献を-,
第38回日本呼吸器外科学会学術集会(Web開催), 2021年5月. 松本大資, 河北直也, 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肺切除術後に気管支鏡処置が必要な無気肺を発症するハイリスク患者群の抽出,
第121回日本外科学会定期学術集会, 2021年4月. 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
発達した気管支動脈は術中出血と手術時間延長のリスク因子である,
第121回日本外科学会定期学術集会, 2021年4月. 宮本直輝, 近藤和也, 南城和正, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
診断に苦慮したmicronodular thymic carcinomaの1例,
第40回日本胸腺研究会, 2021年2月. 六車京香, 近藤和也, 副島志帆, Bilguun tegshee, 山下理子, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるMT1A遺伝子のDNAメチル化とmRNA発現,
第40回日本胸腺研究会, 2021年2月. 大谷環樹, 生島仁史, 坂東良美, 大塚秀樹, 近藤和也, 三好弘一 :
放射線治療効果判定における18F-FLT PETの有効性の検討,
第60回日本核医学学術総会, 2020年11月. 吉田光輝, 近藤和也, 坂東良美, 竹原恵美, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
診断と治療に苦慮した前縦隔粘液線維肉腫の経験,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 副島志帆, 近藤和也, 坪井光弘, 梶浦耕一郎, 六車京香, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍の悪性度とGAD1遺伝子のDNAメチル化と発現,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 張林婉, 近藤和也, 板東孝枝, 今井芳枝, 髙橋亜希, 荒堀広美, 姚人尹, 滝沢宏光, 川上行奎, 吉田光輝, 鳥羽博明, 坪井光弘, 丹黒章 :
手術療法施行した肺がん患者におけるpatient reported quality of life(PRQOL)の評価,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 滝沢宏光, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
蛍光顕微鏡を用いた小型肺腺癌浸潤診断についての検討,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 松本大資, 鳥羽博明, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
切除可能cI-ⅢA期肺扁平上皮癌における術後再発リスクの層別化と治療戦略,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 髙嶋美佳, 鳥羽博明, 庄野隆志, 南城和正, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
アダプター蛋白XB130はⅠ期肺腺癌の予後因子となり得る,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 河北直也, 鳥羽博明, 滝沢宏光, 南城和正, 庄野隆志, 牧秀則, 山本清成, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
小型末梢肺癌診断率向上のためのCone-beam CT併用極細径気管支鏡下生検,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. Tegshee Bilguun, 近藤和也, 副島志帆, 六車京香, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
Expression of variant ligand and receptor of Ghrelin system is related to tumorigenesis of thymoma,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 鳥羽博明, 滝沢宏光, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
高齢肺癌患者を地域で役割分担して診るための包括的な取り組み,
第61回日本肺癌学会学術集会(ハイブリッド形式), 2020年11月. 宮本直輝, 南城和正, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 滝沢宏光, 丹黒章 :
原発性肺癌術後オリゴ肺転移症例についての検討,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 滝沢宏光, 南城和正, 庄野隆志, 山本清成, 牧秀則, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
CTリンパ管造影による肺癌センチネルリンパ節マップの検討,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 南城和正, 庄野隆志, 牧秀則, 山本清成, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
分類不能型縦隔高悪性度腫瘍の手術例の経験,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 髙嶋美佳, 鳥羽博明, 滝沢宏光, 坂本晋一, 宮本直輝, 松本大資, 河北直也, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
地方で働く一呼吸器外科医としての現在地，そしてこれから,
第73回日本胸部外科学会定期学術集会(Web開催), 2020年10月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 牧秀則, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 坂本晋一, 宮本直輝, 松本大資, 髙嶋美佳, 河北直也, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
微小肺病変に対して術中Cone-beam CT併用気管支鏡下コイルマーキングが有用であった1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 宮本直輝, 南城和正, 牧秀則, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腔鏡下に確定診断を得たCalcifying fibrous tumorの1例,
第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会(Web開催), 2020年10月. 山本遥平, 松井尚子, 織田史子, 小澤由希子, 金井哲也, 鵜沢顕之, 大東いずみ, 近藤和也, 桑原聡, 山村隆, 和泉唯信 :
重症筋無力症患者の胸腺ではプラズマブラストが増加している,
第32回日本神経免疫学会学術集会, 2020年10月. 髙嶋美佳, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
神経線維腫症1型を背景とした肋間動脈瘤破裂による血胸に対しソフト凝固により止血し得た1例,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
大腸癌肺転移の肺切除後再発リスク因子,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 河北直也, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 髙嶋美佳, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
ステロイドが遷延性肺瘻に与える影響,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 松本大資, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
コイルと色素を併用した気管支鏡下コイルマーキング法による，触知困難小型病変に対する単孔式胸腔鏡下肺部分切除,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 鳥羽博明, 滝沢宏光, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
かかりつけ医と連携してより良い肺癌診療をするための包括的な取り組み,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 坪井光弘, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
進行期胸腺上皮性腫瘍の治療成績の検討,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 吉田光輝, 近藤和也, 大谷環樹, 小川博久, 宮本直輝, 竹原恵美, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
呼吸器外科の癌免疫療法研究-CMT167マウス肺癌細胞株同所移植モデルマウスの確立に向けて-,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 溝渕海, 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第37回日本呼吸器外科学会学術集会(Web開催), 2020年9月. 青山万理子, 滝沢宏光, 井上聖也, 河北直也, 坪井光弘, 近藤和也, 丹黒章 :
小動物用FDG-PET/CTを使用した甲状腺未分化癌の同所移植マウスモデルの作成,
第120回日本外科学会定期学術集会(Web開催), 2020年8月. 松本大資, 河北直也, 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
気管支鏡処置を要する術後無気肺発症のハイリスク患者群の抽出,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 滝沢宏光, 河北直也, Eman Ali, 坪井光弘, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
当科における経気管支生検時併用モダリティ別の診断成績比較Cone-beam CT vs EBUS-GS,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 河北直也, 滝沢宏光, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTを用いた極細径気管支鏡下生検,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 髙嶋美佳, 鳥羽博明, 溝渕海, 竹原恵美, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
進行食道癌による気道狭窄に対するステント留置例の検討,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 吉田光輝, 峯田一秀, 河北直也, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 髙嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
皮膚移植とBACシステムを組み合わせた有瘻性膿胸の治療経験-開創術後のマネジメントにいかに立ち向かうか,
第43回日本呼吸器内視鏡学会学術集会(紙上開催), 2020年6月. 副島志帆, 近藤和也, 六車京香, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるghrelin-GHSR系分子の発現,
第39回日本胸腺研究会, 2020年2月. 山本遥平, 松井尚子, 大東いずみ, 近藤和也, 和泉唯信 :
重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析,
第39回日本胸腺研究会, 2020年2月. 六車京香, 近藤和也, 副島志帆, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるNPTX2遺伝子のDNAメチル化とmRNA，タンパク発現の関係,
第39回日本胸腺研究会, 2020年2月. 吉田光輝, 近藤和也, 北市隆, 尾矢剛志, 松本穣, 宮本直輝, 鈴木恵美, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した分類不能型高悪性度腫瘍の一切除例,
第39回日本胸腺研究会, 2020年2月. 高嶋美佳, 鳥羽博明, 柿内聡司, 宮本直輝, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管瘻を伴った進行肺癌による気道狭窄に対し気道ステント留置により長期にわたり良好なQOLを維持できた1例,
第60回日本肺癌学会学術集会, 2019年12月. 吉田光輝, 小川博久, 湯浅将生, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
定量的三次元CT解析から上皮内癌，微小浸潤癌を予測できるか,
第60回日本肺癌学会学術集会, 2019年12月. 坪井光弘, 近藤和也, 副島志帆, 六車京香, 溝渕海, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
クロム工場従事者の肺癌におけるMLH1遺伝子のメチル化の検討,
第60回日本肺癌学会学術集会, 2019年12月. 副島志帆, 近藤和也, 岸渕麗奈, 六車京香, 坪井光弘, 梶浦耕一郎, Bilguun Tegshee, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍の悪性度の指標としてのGHSRのDNAメチル化,
第60回日本肺癌学会学術集会, 2019年12月. 六車京香, 近藤和也, 副島志帆, 岸渕麗奈, Bilguunmin Tegshee, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるMT1AとNPTX2遺伝子のDNAメチル化とmRNAの発現の関係,
第60回日本肺癌学会学術集会, 2019年12月. 松本大資, 鳥羽博明, 近藤和也, 溝渕海, 竹原恵美, 宮本直輝, 高嶋美佳, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
右肺動脈閉鎖症を伴う右下葉肺癌に対し，胸腔鏡下肺葉切除を行った1例,
第60回日本肺癌学会学術集会, 2019年12月. 鳥羽博明, 松本大資, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
胸腔鏡困難症例をやりやすくするための少しの工夫とリスクマネジメント,
第32回日本内視鏡外科学会総会, 2019年12月. 滝沢宏光, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
蛍光顕微鏡を用いた肺腺癌浸潤診断についての検討,
第60回日本肺癌学会学術集会, 2019年12月. 村上行人, 香川耕造, 小山壱也, 吾妻雅彦, 松本大資, 坪井光弘, 川上行奎, 近藤和也, 佐藤正大, 大塚憲司, 軒原浩, 西岡安彦 :
大量胸水および胸膜腫瘤を契機に診断された甲状腺濾胞癌の一例,
第28回日本呼吸器内視鏡学会中国四国支部会, 2019年11月. 宮本直輝, 吉田光輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 滝沢宏光, 丹黒章 :
胸腔鏡下生検で確定診断を得たCalcifying fibrous tumorの1例,
第62回日本呼吸器学会中国・四国地方会, 2019年11月. 竹原恵美, 鳥羽博明, 溝渕海, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
ニボルマブが奏功し，長期間休止後増悪時に再投与した切除不能肺癌の1例,
第81回日本臨床外科学会総会, 2019年11月. 滝沢宏光, 鳥羽博明, 松本大資, 竹原恵美, 宮本直輝, 高嶋美佳, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《クリニカルビデオセッション》胸腔シミュレータと3D臓器モデルを用いたロボット支援胸腔鏡下肺葉切除の術前トレーニング,
第72回日本胸部外科学会定期学術集会, 2019年10月. 吉田光輝, 小川博久, 湯浅将生, 鈴木恵美, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
上皮内癌，微小浸潤癌の三次元画像解析,
第72回日本胸部外科学会定期学術集会, 2019年10月. 河北直也, 滝沢宏光, 竹原恵美, 宮本直輝, 高嶋美佳, 松本大資, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対するインドシアニングリーン蛍光下手術,
第57回日本癌治療学会学術集会, 2019年10月. 澤田徹, 滝沢宏光, 青山万理子, 竹原恵美, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
共焦点レーザー内視鏡における肺癌胸膜浸潤診断の有用性について,
第57回日本癌治療学会学術集会, 2019年10月. 山本遥平, 松井尚子, 織田史子, 小澤由希子, 金井哲也, 鵜沢顕之, 大東いずみ, 近藤博之, 近藤和也, 北川哲也, 桑原聡, 山村隆, 和泉唯信, 梶龍兒 :
重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析,
第31回日本神経免疫学会学術集会, Vol.24, No.1, 140, 2019年9月. 滝沢宏光, 鳥羽博明, 松本大資, 高嶋美佳, 竹原恵美, 宮本直輝, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下肺葉切除導入期における3D臓器モデルを用いた術前シミュレーション,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 竹原恵美, 滝沢宏光, 溝渕海, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
卒後3年目後期研修医が経験した胸腔鏡下肺悪性腫瘍手術の修練,
第94回中国四国外科学会総会・第24回中国四国内視鏡外科研究会, 2019年9月. 竹原恵美, 滝沢宏光, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
急速増大を示したLCNECの一切除例,
第58回日本肺癌学会中国・四国支部学術集会, 2019年7月. 坪井光弘, 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
極細径気管支鏡下肺生検における到達困難な末梢病変の検討,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 澤田徹, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
共焦点レーザー内視鏡による肺癌胸膜浸潤診断,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 滝沢宏光, 鳥羽博明, 松本大資, 山田亮, 鈴木恵美, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下手術導入における3D臓器モデルを用いた術前トレーニング,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 高嶋美佳, 鳥羽博明, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
食道気管支瘻を伴った食道癌による気管分岐部狭窄に対し気道ステント留置が有効であった1例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 吉田光輝, 岩田貴, 赤池雅史, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章, 鶴尾吉宏 :
《ワークショップ》外科手術教育の当院における取り組み,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 山田亮, 吉田光輝, 河北直也, 鈴木恵美, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌との鑑別に苦慮した，気管内過誤腫による閉塞性肺炎の一切除例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 鈴木恵美, 河北直也, 山田亮, 松本大資, 高嶋美佳, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
高齢者気管支脂肪腫に対し気管支鏡下に切除を行った一例,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 鳥羽博明, 六田暉朗, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡検査用局所麻酔薬噴霧カテーテルスプレーの有用性-第2報-,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
触知困難小型肺病変に対するコイルと色素を用いたマーキング法,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTを用いた極細径気管支鏡下生検の現状と展望,
第42回日本呼吸器内視鏡学会学術集会, 2019年7月. 高嶋美佳, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科における前縦隔腫瘍に対する手術アプローチ法の検討,
第62回関西胸部外科学会学術集会, 2019年6月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
胸腺手術手技の3D CT画像による評価-胸骨正中切開と剣状突起下アプローチの比較検討-,
第62回関西胸部外科学会学術集会, 2019年6月. 高嶋美佳, 鳥羽博明, 笹聡一郎, 松本大資, 井上聖也, 河北直也, 澤田徹, 西野豪志, 坪井光弘, 川上行奎, 吉田卓弘, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
食道気管支瘻を伴った食道癌による気管分岐部狭窄に対し気道ステント留置が有効であった1例,
第62回関西胸部外科学会学術集会, 2019年6月. 河北直也, 滝沢宏光, 近藤和也, 鈴木恵美, 山田亮, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 丹黒章 :
横隔膜交通症に対するICG蛍光ガイド下手術の2例,
第62回関西胸部外科学会学術集会, 2019年6月. Yohei Yamamoto, Naoko Matsui, Fumiko Oda, Yukiko Ozawa, Tetsuya Kanai, Akiyuki Uzawa, Izumi Ohigashi, Hiroyuki Kondo, Kazuya Kondo, Tetsuya Kitagawa, Takashi Yamamura, Satoshi Kuwabara, Yuishin Izumi and Ryuji Kaji :
B cell subsets and T follicular helper cells in myasthenia gravis thymus,
第60回日本神経学会学術大会, May 2019. 滝沢宏光, 鳥羽博明, 松本大資, 山田亮, 鈴木恵美, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
ロボット支援胸腔鏡下手術導入における3D臓器モデルとスキルシミュレータの活用,
第36回日本呼吸器外科学会総会, 2019年5月. 鈴木恵美, 吉田光輝, 東桃代, 山田亮, 松本大資, 高嶋美佳, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科からみた結核スクリーニング-T-SPOT検査は有用であるか-,
第36回日本呼吸器外科学会総会, 2019年5月. 高嶋美佳, 鳥羽博明, 監﨑孝一郎, 鈴木恵美, 山田亮, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腔内洗浄細胞診陽性Ⅰ期肺癌に対する術後化学療法の可能性,
第36回日本呼吸器外科学会総会, 2019年5月. 澤田徹, 近藤和也, 松井尚子, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 丹黒章 :
重症筋無力症に対する拡大胸腺摘出術の有効性について,
第36回日本呼吸器外科学会総会, 2019年5月. 鳥羽博明, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変に対する気管支鏡下コイルマーキングを用いたimage-guided VATS,
第36回日本呼吸器外科学会総会, 2019年5月. 河北直也, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
遷延性肺瘻の予測スコアは治療介入時期決定に有用である-Prospective study-,
第36回日本呼吸器外科学会総会, 2019年5月. 坪井光弘, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
転移性肺腫瘍に対する解剖学的肺切除の役割,
第36回日本呼吸器外科学会総会, 2019年5月. 松本大資, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
腎細胞癌肺転移症例に対する集学的治療としての手術療法の意義,
第36回日本呼吸器外科学会総会, 2019年5月. 濱路政嗣, 寒水孝司, 町田龍之介, 渡辺俊一, 吉田和夫, 豊岡伸一, 丹羽宏, 近藤和也, 堀尾裕俊, 奥村明之進, 伊達洋至 :
胸腺上皮性腫瘍切除後の他癌死リスクの推定:日本胸腺研究会データベースを使用して,
第36回日本呼吸器外科学会総会, 2019年5月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
残存脂肪組織量から拡大胸腺摘出術を考える,
第36回日本呼吸器外科学会総会, 2019年5月. 河北直也, 鳥羽博明, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》遷延性肺瘻の予測スコアは治療介入時期決定に有用である,
第119回日本外科学会定期学術集会, 2019年4月. 坪井光弘, 河北直也, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《ミニシンポジウム》肺野末梢病変に対するCone-beam CTを用いた極細径気管支鏡下肺生検,
第59回日本呼吸器学会学術講演会, 2019年4月. 鳥羽博明, 六田暉朗, 監﨑孝一郎, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡検査用新型局所麻酔薬噴霧カテーテルスプレーの使用経験,
第27回日本呼吸器内視鏡学会中国四国支部会, 2018年12月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
再発胸腺上皮性腫瘍に対する手術療法の意義,
第59回日本肺癌学会総会, 2018年11月. 吉田光輝, 小川博久, 湯浅康弘, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
CTでの充実径計測は妥当か，上皮内癌，微小浸潤癌におけるVINCENT3D解析と病理像の比較,
第59回日本肺癌学会総会, 2018年11月. 坪井光弘, 近藤和也, 高嶋美佳, 松本大資, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《口演》腺癌におけるGAD1発現の臨床的意義,
第59回日本肺癌学会総会, 2018年11月. 副島志帆, ウシマンヌリアミナ, 近藤和也, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《口演》胸腺上皮性腫瘍の悪性度とGAD1(glutamic acid decarboxylase1)遺伝子のDNAメチル化の関係,
第59回日本肺癌学会総会, 2018年11月. 澤田徹, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《口演》肺癌における胸膜浸潤診断の予測因子の検討,
第59回日本肺癌学会総会, 2018年11月. 高嶋美佳, 鳥羽博明, 鈴木恵美, 松本大資, 河北直也, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科における胸腔内洗浄細胞診陽性症例での再発例の検討,
第80回日本臨床外科学会総会, 2018年11月. 鈴木恵美, 高嶋美佳, 鳥羽博明, 吉田卓弘, 松本大資, 森本雅美, 河北直也, 澤田徹, 坪井光弘, 武知浩和, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
放射線皮膚潰瘍・胸骨骨髄炎に対し広汎骨性胸郭切除を行った乳癌再発の1例,
第80回日本臨床外科学会総会, 2018年11月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《一般口演》肺癌胸膜浸潤の術中評価における我々の取り組み,
第39回日本レーザー医学会総会, 2018年11月. 高嶋美佳, 吉田光輝, 近藤和也, 坪井光弘, 河北直也, 澤田徹, 鈴木恵美, 山田亮, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
剣状突起下アプローチ拡大胸腺摘出術の当院における導入の経験,
第93回中国四国外科学会総会・第23回中国四国内視鏡外科研究会, 2018年9月. 鈴木恵美, 吉田光輝, 近藤和也, 山田亮, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
前縦隔に発生した粘液線維肉腫の一切除例,
第59回日本呼吸器学会中国・四国地方会/第57回日本肺癌学会中国・四国支部学術集会, 2018年7月. 山田亮, 吉田光輝, 河北直也, 鈴木恵美, 高嶋美佳, 松本大資, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌との鑑別に苦慮した，気管内過誤腫による閉塞性肺炎の一切除例,
第59回日本呼吸器学会中国・四国地方会/第57回日本肺癌学会中国・四国支部学術集会, 2018年7月. 河北直也, 滝沢宏光, 吉田卓弘, 澤田徹, 井上聖也, 後藤正和, 西野豪志, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《Case Presentation Award》有茎大網弁被覆により有瘻性膿胸を回避できた右上葉管状肺葉切除の1例,
第61回関西胸部外科学会学術集会, 2018年6月. Yamamoto Yohhei, Naoko Matsui, Kazuya Kondo, Izumi Ohigashi, Yousuke Takahama, Nakagawa Hidewaki, Yuishin Izumi and Ryuji Kaji :
Analysis of human thymic epithelial cells,
第59回日本神経学会学術大会, May 2018. 河北直也, 滝沢宏光, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CT併用による極細径気管支鏡下肺生検の初期導入経験,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 坪井光弘, 滝沢宏光, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Cone-beam CTガイド下肺野末梢病変の経気管支鏡診断においてCBCT signは重要である,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 松本大資, 中川靖士, 広瀬敏幸, 近藤和也 :
VA ECMO下に気道ステント留置を行った，右肺全摘後の左主気管支狭窄の1例,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 澤田徹, 吉田光輝, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》気管支鏡の故障をいかに防ぐか∼我々の知るべきこと∼,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 吉田光輝, 東桃代, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》結核スクリーニングにおけるT-SPOT測定-気管支鏡検査，胸腔鏡生検の役割-,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 鳥羽博明, 六田暉朗, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《Oralセッション》気管支鏡検査用新型局所麻酔薬噴霧カテーテルスプレーの使用経験,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《Videoセッション》Hybrid手術室で行う小型末梢肺病変に対するCone-beam CTガイド下気管支鏡下コイルマーキング,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 滝沢宏光, 河北直也, 吉田光輝, 井上聖也, 後藤正和, 西野豪志, 吉田卓弘, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
《シンポジウム》未固体遺体による高難度手術の術前シミュレーション,
第41回日本呼吸器内視鏡学会学術集会, 2018年5月. 滝沢宏光, 河北直也, 澤田徹, 西野豪志, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《一般示説》微小浸潤性腺癌を術前診断するのは困難である,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 澤田徹, 近藤和也, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般示説》重症筋無力症の拡大胸腺摘出術の長期効果と周術期管理,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 坪井光弘, 近藤和也, 河北直也, 澤田徹, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般口演》根治手術後の胸腺癌の再発病変に対する治療,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般口演》肺葉切除後の肺静脈断端血栓とそれに起因する合併症,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 近藤和也, 副島志帆, ウシマンヌリアミナ, 岸渕麗奈, 坪井光弘, 梶浦耕一郎, 川上行奎, 河北直也, 澤田徹, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《要望演題》胸腺上皮性腫瘍におけるGAD1(glutamic acid decarboxylase1)遺伝子のDNAメチル化とmRNA，蛋白発現,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 河北直也, 鳥羽博明, 澤田徹, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《要望演題》遷延性肺瘻の予測因子に基づいた治療方針決定の可能性,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 吉田光輝, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
《要望演題》微小浸潤癌，上皮内癌の組織像と定量的CT画像解析の検討-SYNAPSE VINCENTを用いて-,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《シンポジウム》Hybrid手術室で行う小型末梢肺病変に対するCone-beamCTガイド下気管支鏡下コイルマーキング,
第35回日本呼吸器外科学会総会・学術集会, 2018年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変に対するCone-beam CT併用気管支鏡下コイルマーキング-Hybrid手術室で全身麻酔下にすべてできる-,
第118回日本外科学会定期学術集会, 2018年4月. 滝沢宏光, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肺切除が有効である大腸癌肺転移症例の臨床病理学的背景,
第118回日本外科学会定期学術集会, 2018年4月. 青山万理子, 吉田光輝, 行重佐和香, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
後縦隔ミュラー管嚢胞の1例,
第79回日本臨床外科学会総会, 2017年11月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対してICG蛍光観察下に胸腔鏡下肺部分切除を行った1例,
第79回日本臨床外科学会総会, 2017年11月. 行重佐和香, 川上行奎, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Minute pulmonary meningothelial like nodulesの3例,
第79回日本臨床外科学会総会, 2017年11月. 河北直也, Ali Eman, 滝沢宏光, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 丹黒章, 近藤和也 :
《渡辺洋一記念奨励賞選考対象演題》(呼吸器内視鏡)コンビームCTによる気管支鏡生検の検査精度向上,
第26回日本呼吸器内視鏡学会中国四国支部会, 2017年10月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるCDH3のDNAメチル化,
第58回日本肺癌学会学術集会, 2017年10月. 松本充鈴, 田岡志津佳, 板東孝枝, 近藤和也, 梶浦耕一郎, 滝沢宏光, 今井芳枝, 髙橋亜希, 雄西智惠美 :
治療過程にある再発・転移肺がん患者の心理的適応,
第58回日本肺癌学会学術集会, Vol.57, No.5, 437, 2017年10月. 松井尚子, 大東いずみ, Myn Muhammad Uddin, 佐坂開人, 山本遥平, 古川貴大, 近藤和也, 中川英刀, 梶龍兒, 高浜洋介 :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第29回日本神経免疫学会学術集会, 2017年10月. 山本遥平, 松井尚子, 鵜沢顕之, 佐坂開人, 古川貴大, 近藤和也, 北川哲也, 桑原聡, 山村隆, 梶龍兒 :
MG患者の胸腺と末梢血におけるB細胞の解析,
第29回日本神経免疫学会学術集会, 2017年10月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
肺癌術前のリンパ節転移評価におけるPET-CT検査の診断精度,
第70回日本胸部外科学会定期学術集会, 2017年9月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
《一般口演》凝固壊死を伴う胸腺上皮性腫瘍の検討,
第70回日本胸部外科学会定期学術集会, 2017年9月. Naoko Matsui, Izumi Ohigashi, Yamamoto Yohei, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji :
Approach for analysis of human thymic epithelial cells,
XX World Congress of Neurology, Sep. 2017. 久保亜貴子, 外礒千智, 近藤和也, 古谷俊介, 生島仁史, 原田雅史 :
腋窩・鎖骨上領域を含めた乳癌術後照射における放射線肺臓炎の検討,
第53回日本医学放射線学会秋季臨床大会, 2017年9月. 梶浦耕一郎, 吉田光輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
前方後方アプローチにて摘出した胸腔内ダンベル型神経線維腫症の1例,
第42回日本外科系連合学会学術集会, 2017年6月. 藤本啓介, 河北直也, 梶浦耕一郎, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺切除術直後に急性心筋梗塞を発症した1例,
第42回日本外科系連合学会学術集会, 2017年6月. 河北直也, 藤本啓介, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 先山正二, 広瀬敏幸, 丹黒章 :
BEP療法中に発症した間質性肺炎治療後に手術を施行した2例,
第42回日本外科系連合学会学術集会, 2017年6月. 吉田光輝, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野恒作, 鶴尾吉宏 :
鏡視下手術時代の教育の開発未固定遺体を用いた胸腔鏡手術トレーニングの経験,
第42回日本外科系連合学会学術集会, 2017年6月. 澤田徹, 滝沢宏光, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
胸腔鏡下手術における3D内視鏡システムの有用性について,
第42回日本外科系連合学会学術集会, 2017年6月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》当院における肺がん術後連携クリニカルパス-連携不良例から今後の方向性を考える-,
第42回日本外科系連合学会学術集会, 2017年6月. 宮本直輝, 吉田光輝, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
DynaCTの気管支鏡生検における可能性,
第40回日本呼吸器内視鏡学会学術集会, 2017年6月. 梶浦耕一郎, 滝沢宏光, 坪井光弘, 澤田徹, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
有瘻性膿胸に対するEWSを用いた気管支充填術,
第40回日本呼吸器内視鏡学会学術集会, 2017年6月. 吉田光輝, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科手術における血管の破格症例,
第26回日本癌病態治療研究会, 2017年6月. 川上行奎, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
肺癌術後再発の長期生存例の検討,
第26回日本癌病態治療研究会, 2017年6月. 梶浦耕一郎, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
縦隔嚢胞性疾患における嚢胞内成分の鑑別指標となる画像診断,
第34回日本呼吸器外科学会総会, 2017年5月. 宮本直輝, 吉田光輝, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
ハイブリッド手術室を利用したVATSの経験,
第34回日本呼吸器外科学会総会, 2017年5月. 澤田徹, 坪井光弘, 宮本直輝, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Trimodality theraphyにおける治療前後のSUVmaxと治療効果の関連性の検討,
第34回日本呼吸器外科学会総会, 2017年5月. 吉田光輝, 近藤和也, 梶浦耕一郎, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
《一般口演》胸腺腫における石灰化は意義を持つのか,
第34回日本呼吸器外科学会総会, 2017年5月. 川上行奎, 青山万理子, 河北直也, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般ビデオ》S6区域切除+フラップ気管支形成術を行った気管支内過誤腫の一例,
第34回日本呼吸器外科学会総会, 2017年5月. 鳥羽博明, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《要望ビデオ》多発GGO病変に対して気管支鏡下コイルマーキングでS1側のマージンを担保した完全鏡視下右S2区域切除,
第34回日本呼吸器外科学会総会, 2017年5月. 坪井光弘, 吉田光輝, 河北直也, 梶浦耕一郎, 澤田徹, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章, 須田隆 :
《要望演題》当科における剣状突起下切開単孔式胸腺摘出導入の取り組み-未固定遺体を用いた手術トレーニングについて-,
第34回日本呼吸器外科学会総会, 2017年5月. 河北直也, 鳥羽博明, 広瀬敏幸, 松本大資, 澤田徹, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《シンポジウム》pStageⅠ肺腺癌の治療戦略-簡便な3因子を用いた予後の層別化と術後補助療法の可能性-,
第34回日本呼吸器外科学会総会, 2017年5月. 吉田光輝, 滝沢宏光, 吉田卓弘, 坪井光弘, 河北直也, 澤田徹, 梶浦耕一郎, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章, 岩田貴, 赤池雅史, 金山博臣, 東野耕作, 鶴尾吉宏 :
《考える外科学》未固定遺体とのシミュレーションを用いた新たな実践型内視鏡下低侵襲手術トレーニングプログラムの構築,
第117回日本外科学会定期学術集会, 2017年4月. 澤田徹, 滝沢宏光, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
胸腔鏡下手術における3D内視鏡システムの有用性について,
第56回日本呼吸器学会中国・四国地方会/第25回日本呼吸器内視鏡学会中国四国支部会, 2016年12月. 梶浦耕一郎, 近藤和也, 三好孝典, 松本大資, 中川靖士, 石倉久嗣, 松岡永, 監﨑孝一郎, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
胸膜播種を伴う胸腺上皮性腫瘍の検討,
第57回日本肺癌学会総会, 2016年12月. 宮本直輝, 吉田光輝, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
右上葉区域肺静脈(V2)の分岐走行異常の検討,
第57回日本肺癌学会総会, 2016年12月. 澤田徹, 鳥羽博明, 宮本直輝, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺上皮性腫瘍におけるFDG-PET/CTの有用性∼SUVmax値はRFSの予測因子になるか?,
第57回日本肺癌学会総会, 2016年12月. 河北直也, 鳥羽博明, 澤田徹, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》根治切除を行ったpStageⅠ肺腺癌の予後因子による層別化,
第57回日本肺癌学会総会, 2016年12月. 近藤和也 :
《ワークショップ》胸腺上皮性腫瘍特性と治療法,
第57回日本肺癌学会総会, 2016年12月. 宮本直輝, 梶浦耕一郎, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
同一病変内に放線菌症とAdenocarcinomaを併発した一例,
第78回日本臨床外科学会総会, 2016年11月. 梶浦耕一郎, 滝沢宏光, 宮本直輝, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
Thopaz®によるドレーン管理中に起こった右肺全摘術後の皮下気腫の1例,
第78回日本臨床外科学会総会, 2016年11月. 西岡康平, 鳥羽博明, 藤本啓介, 宮本直輝, 河北直也, 澤田徹, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
再生不良性貧血を合併した胸腺腫に対して，術前大量ステロイド療法後に手術を施行し，pCRが得られた1例,
第78回日本臨床外科学会総会, 2016年11月. 河北直也, 滝沢宏光, 梶浦耕一郎, 藤本啓介, 西岡康平, 宮本直輝, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
肝性胸水に対する胸腔鏡下横隔膜修復術の1例-術中気腹法およびICG蛍光法併用の試み-,
第78回日本臨床外科学会総会, 2016年11月. 梶浦耕一郎, 近藤和也, 澤田徹, 坪井光弘, 河北直也, 川上行奎, 鳥羽博明, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺腫瘍におけるRASSF1のDNAメチル化の検討,
第69回日本胸部外科学会定期学術集会, 2016年9月. 吉田光輝, 近藤和也, 中川靖士, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
《一般口演》胸腺腫非合併重症筋無力症患者の術前3D画像評価-拡大胸腺摘出術後の予後予測は可能か-,
第69回日本胸部外科学会定期学術集会, 2016年9月. 坪井光弘, 滝沢宏光, 河北直也, 澤田徹, 西野豪志, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
《一般口演》疾患特性に応じた続発性気胸に対する治療戦略,
第69回日本胸部外科学会定期学術集会, 2016年9月. 宮本直輝, 河北直也, 藤本啓介, 西岡康平, 青山万理子, 澤田徹, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 先山正二, 丹黒章 :
《後期研修医セッション:呼吸器1》FDG-PET/CT陽性を呈した肺原発benign perivascular epithelioid cell tumorの一例,
第91回中国四国外科学会総会・第21回中国四国内視鏡外科研究会, 2016年9月. 梶浦耕一郎, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
EWSによる気管支充填術の有用性評価,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 松本大資, 滝沢宏光, 乾友浩, 髙杉遥, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 先山正二, 丹黒章 :
肺癌術後に気管支鏡的処置を要した症例の検討,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 河北直也, 鳥羽博明, 先山正二, 松本大資, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
選択的肺葉ブロックが有用であった肺切除術の2例,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
人工気胸を併用した胸腔鏡下胸腺部分切除の1例,
第39回日本呼吸器内視鏡学会学術集会, 2016年6月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
未確診肺結節のVATS切除における肺結核感染予防体制の構築,
第41回日本外科系連合学会学術集会, 2016年6月. 松本大資, 先山正二, 乾友浩, 高杉遥, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
当科で経験した縦隔胚細胞腫瘍切除例の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 梶浦耕一郎, 近藤和也, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺上皮性腫瘍の新TNM分類の妥当性,
第33回日本呼吸器外科学会総会, 2016年5月. 河北直也, 滝沢宏光, 川上行奎, 乾友浩, 髙杉遥, 松本大資, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 近藤和也, 先山正二, 丹黒章 :
肝細胞癌肺転移における術中ICG蛍光観察の意義,
第33回日本呼吸器外科学会総会, 2016年5月. 川上行奎, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
原発性肺癌術後の胸腔内リンパ節再発例の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 坪井光弘, 滝沢宏光, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
非小細胞肺癌における胸膜浸潤とskipリンパ節転移の検討,
第33回日本呼吸器外科学会総会, 2016年5月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
Ⅰ期非小細胞肺癌に対する消極的部分切除,
第33回日本呼吸器外科学会総会, 2016年5月. 滝沢宏光, 梶浦耕一郎, 坪井光弘, 鳥羽博明, 松本大資, 河北直也, 西野豪志, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
術前CTリンパ管造影による肺癌センチネルリンパ節同定,
第33回日本呼吸器外科学会総会, 2016年5月. 先山正二, 梶浦耕一郎, 乾友浩, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
分葉不全部を右S6からS2に広がる非浸潤肺癌に対して完全胸腔鏡下にS6+S2区域切除を施行した一例,
第33回日本呼吸器外科学会総会, 2016年5月. Kazuya Kondo, Okumura Meinoshin, Yoshino Ichiro and Yano Motoki :
ESTS-JACS joint symposiumThymic tumor database in Japan,
第33回日本呼吸器外科学会総会, May 2016. 梶浦耕一郎, 近藤和也, 坪井光弘, 鳥羽博明, 滝沢宏光, 川上行奎, 先山正二, 丹黒章 :
胸腺神経内分泌腫瘍におけるRASSF1のDNAメチル化,
第35回日本胸腺研究会, 2016年2月. 松井尚子, 大東いずみ, 中川靖士, 近藤和也, 高浜洋介 :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, 2016年2月. 坪井光弘, 近藤和也, 梶浦耕一郎, 乾友浩, 髙杉遥, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
PET-CTで広汎にFDG陽性リンパ節を伴ったリンパ濾胞性胸腺過形成の1例,
第35回日本胸腺研究会, 2016年2月. 鳥羽博明, 先山正二, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
繰り返す喀血に対して極細径気管支鏡で確認できた気管支動脈瘤の1例,
第24回日本呼吸器内視鏡学会中国四国支部会, 2015年12月. 西野豪志, 吉田卓弘, 滝沢宏光, 乾友浩, 髙杉遥, 松本大資, 井上聖也, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
胸部外科領域における周術期口腔機能管理の術後肺炎予防効果,
第77回日本臨床外科学会総会, 2015年11月. 梶浦耕一郎, 先山正二, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌手術症例の術前予後予測因子としてのmGPSとNLRの検討,
第56回日本肺癌学会総会, 2015年11月. 松本大資, 川上行奎, 滝沢宏光, 近藤和也, 乾友浩, 髙杉遥, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 先山正二, 丹黒章 :
肺葉切除22年後に胸壁転移を来したALK遺伝子変異陽性肺癌の1例,
第56回日本肺癌学会総会, 2015年11月. 坪井光弘, 松本大資, 河北直也, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
進行肺癌に対する術前化学放射線療法の検討,
第56回日本肺癌学会総会, 2015年11月. 河北直也, 先山正二, 坪井光弘, 乾友浩, 髙杉遥, 松本大資, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》転移性肺腫瘍に対する完全胸腔鏡下S7区域切除術の1例,
第56回日本肺癌学会総会, 2015年11月. 滝沢宏光, 近藤和也, 乾友浩, 髙杉遥, 松本大資, 河北直也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 吉田光輝, 先山正二, 丹黒章 :
《口演》胸膜の自家蛍光減弱は肺癌の浸潤性を反映する,
第56回日本肺癌学会総会, 2015年11月. 西野豪志, 滝沢宏光, 乾友浩, 髙杉遥, 松本大資, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
周術期口腔機能管理の肺癌術後肺炎予防効果についての検討,
第68回日本胸部外科学会定期学術集会, 2015年10月. 髙杉遥, 鳥羽博明, 先山正二, 河北直也, 坪井光弘, 梶浦耕一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫再発5年後という晩期に赤芽球癆を発症し，シクロスポリンにて症状の改善を認めた1例,
第90回中国四国外科学会総会, 2015年9月. 河北直也, 鳥羽博明, 乾友浩, 髙杉遥, 坪井光弘, 梶浦耕一郎, 川上行奎, 滝沢宏光, 近藤和也, 先山正二 :
縦隔悪性胚細胞性腫瘍に対するBEP療法中に発症した間質性肺炎後の手術療法の1例,
第53回日本呼吸器学会中国・四国地方会/第54回日本肺癌学会中国・四国支部会, 2015年7月. 河北直也, 鳥羽博明, 先山正二, 三好孝典, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
小型末梢肺病変の安全確実な鏡視下切除のためのCTガイド下気管支鏡下コイルマーキング,
第40回日本外科系連合学会学術集会, 2015年6月. 乾友浩, 滝沢宏光, 近藤和也, 川上行奎, 坂本晋一, 住友弘幸, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 先山正二, 丹黒章 :
肺大細胞癌術後空調転移に対して手術と化学療法を行い長期生存が得られた1例,
第58回関西胸部外科学会学術集会, 2015年6月. 梶浦耕一郎, 先山正二, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気道確保を要した気管支鏡下生検による気道出血症例,
第38回日本呼吸器内視鏡学会学術集会, 2015年6月. Naoko Matsui, Waka Sakai, Takahiro Furukawa, Takako Matsuoka, Masakazu Nakamura, Toshimasa Aranami, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama, Takashi Yamamura and Ryuji Kaji :
B cell analysis in human thymus,
第56日本神経学会学術大会, May 2015. 坂本晋一, 梶浦耕一郎, 近藤和也, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
梗塞性壊死を伴う嚢胞性胸腺腫の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 滝沢宏光, 先山正二, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 丹黒章, 近藤和也 :
大腸癌肺転移切除例の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 梶浦耕一郎, 先山正二, 坂本晋一, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
微小乳頭状パターンを伴う肺癌症例の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 住友弘幸, 鳥羽博明, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 丹黒章, 近藤和也 :
左上葉肺癌術後に生じた右難治性気胸の一例,
第32回日本呼吸器外科学会総会, 2015年5月. 川上行奎, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
左下葉肺門部肺癌に対し，下葉+舌区切除および気管支管状切除にて左肺全摘を回避できた一例,
第32回日本呼吸器外科学会総会, 2015年5月. 坪井光弘, 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
末梢小型肺癌における胸膜浸潤とFDG集積の検討,
第32回日本呼吸器外科学会総会, 2015年5月. 鳥羽博明, 先山正二, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺癌術後無症候性患者でのPET/CTを用いたフォローアップ,
第32回日本呼吸器外科学会総会, 2015年5月. 西野豪志, 滝沢宏光, 住友弘幸, 坂本晋一, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
原発性肺癌における周術期口腔機能管理の有用性について,
第32回日本呼吸器外科学会総会, 2015年5月. 先山正二, 鳥羽博明, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植による肺の再生と修復,
第55回日本呼吸器学会学術講演会, 2015年4月. 川上行奎, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
左肺上葉切除は術後動脈血栓症の危険因子か?-各肺葉切除後，肺静脈断端血栓の有無の比較-,
第115回日本外科学会定期学術集会, 2015年4月. 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
データ解析に基づいたVATS肺葉切除術における術式工夫,
第115回日本外科学会定期学術集会, 2015年4月. 近藤和也, 中島淳, 奥村明之進, 吉野一郎, 藤井義敬, 浅村尚生, 吉田和夫, 伊達洋至, 横井香平, 先山正二, 滝沢宏光, 中川靖士, 梶浦耕一郎, 川上行奎, 丹黒章 :
胸腺上皮性腫瘍のリンパ節転移・遠隔転移に対する治療戦略,
第115回日本外科学会定期学術集会, 2015年4月. 乾友浩, 坪井光弘, 坂本晋一, 住友弘幸, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
喀血を繰り返した気管支動脈蔓状血管腫の1例,
第76回日本臨床外科学会総会, 2014年11月. 猪子未希, 坪井光弘, 坂本晋一, 住友弘幸, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
肺癌術後間質性肺炎急性増悪4例の検討,
第76回日本臨床外科学会総会, 2014年11月. 坪井光弘, 滝沢宏光, 梶浦耕一郎, 坂本晋一, 住友弘幸, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
肺区域切除におけるICG静注による新たな区域間同定法,
第76回日本臨床外科学会総会, 2014年11月. 坪井光弘, 滝沢宏光, 坂本晋一, 住友弘幸, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《パネルディスカッション》難治性気胸に対する治療戦略-気管支塞栓術と胸腔内フィブリン糊注入療法の比較-,
第76回日本臨床外科学会総会, 2014年11月. 板東孝枝, 近藤和也, 劉環, 今井芳枝, 梶浦耕一郎, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 先山正二, 鳥羽博明, 雄西智惠美, 丹黒章 :
手術療法施行した肺がん患者のpatient reported quality of life(PRQOL)及び心理状態のの評価(第2報),
第55回日本肺癌学会学術集会, 2014年11月. 滝沢宏光, 住友弘幸, 坂本晋一, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 丹黒章, 近藤和也, 森下敦司, 河北直也, 広瀬敏幸 :
自家蛍光内視鏡による胸膜浸潤診断能の検証,
第55回日本肺癌学会学術集会, 2014年11月. 川上行奎, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
病理病期1期，非小細胞肺癌術後再発例の検討,
第67回日本胸部外科学会定期学術集会, 2014年9月. 吉田卓弘, 古北由仁, 西野豪志, 坂本晋一, 住友弘幸, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
《口演》開胸食道切除術後の心血管イベント発症防止に対する塩酸ランジオロールの周術期投与の有用性に関する検討,
第67回日本胸部外科学会定期学術集会, 2014年9月. 先山正二, 鳥羽博明, 吉田光輝, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
《口演》胎生期肺組織移植におけるglucocorticoid投与は移植肺組織においてelastinの発現を促進する,
第67回日本胸部外科学会定期学術集会, 2014年9月. 坪井光弘, 森下敦司, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
《要望ビデオセッション:手術手技》呼吸器外科手術におけるPowered ECHELON FLEXTMの使用経験,
第57回関西胸部外科学会学術集会, 2014年6月. 坂本晋一, 梶浦耕一郎, 武知浩和, 森下敦司, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
診断困難であったgefitinib投与中に発生した肺癌術後脳転移の1例,
第31回日本呼吸器外科学会総会, 2014年5月. 先山正二, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章, 浜口伸正, 吉澤潔, 木村秀, 住友正幸, 三好孝典, 日野弘之 :
呼吸器外科専門医の育成と維持-地域の現状と今後-,
第31回日本呼吸器外科学会総会, 2014年5月. 住友弘幸, 滝沢宏光, 先山正二, 吉田光輝, 坂本晋一, 森下敦司, 西野豪志, 坪井光弘, 梶浦耕一郎, 中川靖士, 川上行奎, 丹黒章, 近藤和也 :
肺原発滑膜肉腫の1切除例,
第31回日本呼吸器外科学会総会, 2014年5月. 川上行奎, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
発症から数ヵ月を経て診断された後，異なる治療経過をたどった肺切除後，気管支断端瘻の2例,
第31回日本呼吸器外科学会総会, 2014年5月. 森下敦司, 滝沢宏光, 近藤和也, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 丹黒章, 河北直也, 広瀬敏幸, 住友正幸 :
胸膜浸潤の術中評価はどの程度正確か,
第31回日本呼吸器外科学会総会, 2014年5月. 梶浦耕一郎, 先山正二, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
《一般ビデオ》ジェット換気を用いた気管腺様嚢胞癌に対する気管環状切除の1例,
第31回日本呼吸器外科学会総会, 2014年5月. 坪井光弘, 滝沢宏光, 森下敦司, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《一般口演》肺癌手術症例における胸膜浸潤とリンパ節転移に関する検討,
第31回日本呼吸器外科学会総会, 2014年5月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 森下敦司, 西野豪志, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
《要望ビデオ》胸膜の自家蛍光を用いた胸膜浸潤の術中診断,
第31回日本呼吸器外科学会総会, 2014年5月. 西野豪志, 先山正二, 森下敦司, 坪井光弘, 梶浦耕一郎, 滝沢宏光, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《要望演題》難治性気胸に対する治療戦略∼当科における胸腔内フィブリン糊注入療法の成績と工夫∼,
第31回日本呼吸器外科学会総会, 2014年5月. 長瀬紗季, 梶浦耕一郎, 滝沢宏光, 森下敦司, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
慢性有ろう性膿胸に対する人工呼吸管理下のEWSによる気管支充填術が有効であった1例,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 先山正二, 鳥羽博明, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植における気道系の分化とbranchingに関する検討,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 先山正二, 森下敦司, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気管支鏡関連医療事故の分析とその対応を考える,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 坪井光弘, 森下敦司, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
自家蛍光観察による胸膜浸潤の術中診断精度向上にむけた取り組み,
第37回日本呼吸器内視鏡学会学術集会, 2014年4月. 先山正二, 滝沢宏光, 梶浦耕一郎, 坪井光弘, 中川靖士, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
《ビデオシンポジウム》肺癌に対するロボット補助下肺葉切除術-とくに触覚の決如に関して-,
第114回日本外科学会定期学術集会, 2014年4月. 滝沢宏光, 近藤和也, 梶浦耕一郎, 坪井光弘, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
《シンポジウム》肺癌区域切除におけるリンパ節転移と胸膜浸潤の術中診断精度向上に向けた取り組み,
第114回日本外科学会定期学術集会, 2014年4月. 梶浦耕一郎, 先山正二, 坪井光弘, 吉田光輝, 森下敦司, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
術前気道確保に気管支鏡下高周波スネア切除術が有効であった気管腺様嚢胞癌の1例,
第22回日本呼吸器内視鏡学会中国四国支部会, 2014年2月. 北川聡美, 尼子裕弓, 遠藤世界, 今井芳枝, 雄西智惠美, 板東孝枝, 近藤和也 :
外来化学療法を受けている患者が家族に求めるサポート,
第33回日本看護科学学会学術集会講演集, Vol.1, No.1, 393, 2013年12月. 江口理沙, 河口由美, 今井芳枝, 雄西智惠美, 板東孝枝, 近藤和也 :
がん性疼痛に対する整体手技療法の疼痛緩和の効果に関する文献レビュー,
第33回日本看護科学学会学術集会講演集, 398, 2013年12月. 大谷環樹, 大塚秀樹, 近藤和也, 滝沢宏光, 三好弘一 :
肺癌同所移植モデルマウスの18F-FDG PET/CTイメージング,
日本放射線安全管理学会第12回学術大会, 2013年11月. 劉環, 近藤和也, 板東孝枝, 梶浦耕一郎, 今井芳枝, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 先山正二, 丹黒章 :
手術療法施行した肺がん患者におけるpatient reported quality of life(PRQOL)の評価,
第54回日本肺癌学会総会, 2013年11月. 滝沢宏光, 近藤和也, 大谷環樹, 大塚秀樹, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
PET/CTによるヒト肺癌細胞株肺移植モデルマウスの腫瘍評価,
第54回日本肺癌学会総会, 2013年11月. 中川靖士, 近藤和也, 先山正二, 川上行奎, 滝沢宏光, 吉田光輝, 梶浦耕一郎, 坪井光弘, 丹黒章 :
胸腺上皮性腫瘍83例の検討,
第54回日本肺癌学会総会, 2013年11月. 川上行奎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
当科における異時性多発肺癌手術例の検討,
第54回日本肺癌学会総会, 2013年11月. 梶浦耕一郎, 先山正二, 森下敦司, 西野豪志, 坪井光弘, 古北由仁, 武知浩和, 吉田卓弘, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
褐色細胞腫肺転移の1切除例,
第75回日本臨床外科学会総会, 2013年11月. 岸田弥奈, 大谷環樹, 大塚秀樹, 近藤和也 :
肺癌同所移植モデルマウスの経時的測定におけるPET呼吸同期収集がSUVに与える影響について,
中四国放射線技術ファーラム2013, 2013年11月. Mohammed Mokhtar, 田所由紀子, 中川美砂子, 森本雅美, 武知浩和, 近藤和也, 丹黒章 :
当院における乳癌センチネルリンパ節生検(CTリンパ管造影，色素法，蛍光法，OSNA法),
第51回日本癌治療学会学術集会, 2013年10月. 梶浦耕一郎, 近藤和也, 滝沢宏光, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 古北由仁, 西野豪志, 吉田卓弘, 先山正二, 丹黒章 :
胸腺腫術後再発治療の検討,
第66回日本胸部外科学会定期学術集会, 2013年10月. 吉田光輝, 先山正二, 日野弘之, 高嶋美佳, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章 :
解剖学的破格を伴う胸部手術症例,
第66回日本胸部外科学会定期学術集会, 2013年10月. 先山正二, 吉田光輝, 川上行奎, 監﨑孝一郎, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
胎生期肺組織移植におけるGlucocorticoid投与は移植肺の分化を促進する,
第66回日本胸部外科学会定期学術集会, 2013年10月. 梶浦耕一郎, 井本逸勢, 増田清士, 田嶋敦, 近藤和也, 丹黒章 :
ゲノムワイドな異常DNAメチル化探索によるにおける新規メチル化標的喫煙関連肺腺癌抑制遺伝子の同定,
第72回日本癌学会学術総会, 2013年10月. 吉田光輝, 先山正二, 森下敦司, 西野豪志, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
呼吸器外科領域におけるQuantiFERON-TB検査の医療安全面からの有用性,
第49回日本呼吸器学会中国四国地方会・第52回日本肺癌学会中国四国支部会, 2013年7月. 森下敦司, 滝沢宏光, 坪井光弘, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
甲状腺癌多発肺転移に原発性肺癌を合併した1例,
第49回日本呼吸器学会中国四国地方会・第52回日本肺癌学会中国四国支部会, 2013年7月. 池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科治療抵抗性の乳児気管支肉芽に対してHo : YAGレーザー焼灼術を施行した1例,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 滝沢宏光, 梶浦耕一郎, 池田真由美, 古川尊子, 西野豪志, 森本雅美, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
《シンポジウム》術前経気管支水溶性造影剤注入CTリンパ管造影法による肺癌センチネルリンパ節同定,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 吉田光輝, 先山正二, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
《ワークショップ》QuantiFERON-TB検査の呼吸器外科領域における医療安全面からの有用性,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 梶浦耕一郎, 先山正二, 滝沢宏光, 池田真由美, 古川尊子, 森本雅美, 中川靖士, 川上行奎, 吉田光輝, 近藤和也, 豊田優子, 手塚敏史, 木下勝弘, 青野純典, 西岡安彦, 丹黒章 :
《ワークショップ》気管支鏡破損症例の検討,
第36回日本呼吸器内視鏡学会学術集会, 2013年6月. 池田真由美, 西野豪志, 先山正二, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫術後に両側横隔神経麻痺による呼吸不全をきたした1例,
第56回関西胸部外科学会学術集会, 2013年6月. 川上行奎, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
胸腺上皮性腫瘍におけるFDG PET-CTの有用性‐組織型，正岡分類との関連性につき-,
第30回日本呼吸器外科学会総会, 2013年5月. 池田真由美, 吉田光輝, 先山正二, 古川尊子, 梶浦耕一郎, 武知浩和, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
サルコイドーシス合併肺腺癌術後にSIADHを合併した1例,
第30回日本呼吸器外科学会総会, 2013年5月. 梶浦耕一郎, 滝沢宏光, 先山正二, 古川尊子, 西野豪志, 森本雅美, 吉田光輝, 川上行奎, 中川靖士, 近藤和也, 丹黒章 :
塩酸ランジオロールの肺葉切除後上室性不整脈予防効果の検討,
第30回日本呼吸器外科学会総会, 2013年5月. 古川尊子, 吉田光輝, 先山正二, 池田真由美, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
非連続性多発性腫瘤を呈した悪性胸膜中皮腫の1手術例,
第30回日本呼吸器外科学会総会, 2013年5月. 吉田光輝, 先山正二, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 梶浦耕一郎, 鳥羽博明, 中川靖士, 滝沢宏光, 川上行奎, 近藤和也, 丹黒章 :
侵襲型肺アスペルギルス症に対する右肺全摘術の経験,
第30回日本呼吸器外科学会総会, 2013年5月. 先山正二, 滝沢宏光, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
縦隔型舌区動脈を有する肺癌症例に対するロボット補助下左上葉切除術,
第30回日本呼吸器外科学会総会, 2013年5月. 吉田光輝, 近藤和也, 中川靖士, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
重症筋無力症患者の術前3D画像解析が拡大胸腺摘出術後の予後予測に及ぼす可能性,
第113回日本外科学会定期学術集会, 2013年4月. 梶浦耕一郎, 川上行奎, 池田真由美, 古川尊子, 森本雅美, 西野豪志, 後藤正和, 中川美砂子, 山本洋太, 古北由仁, 武知浩和, 中川靖士, 吉田光輝, 滝沢宏光, 田所由紀子, 先山正二, 近藤和也, 丹黒章 :
YAGレーザー使用時の気管支鏡破損の1例,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 古川尊子, 吉田光輝, 梶浦耕一郎, 先山正二, 滝沢宏光, 森本雅美, 武知浩和, 池田真由美, 西野豪志, 中川靖士, 川上行奎, 近藤和也, 丹黒章 :
当科における気管支鏡検査へのLung pointの経験,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 池田真由美, 滝沢宏光, 古川尊子, 西野豪志, 後藤正和, 梶浦耕一郎, 中川靖士, 川上行奎, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
内科的治療抵抗性の乳児気管支肉芽に対してHo:YAGレーザー焼灼術を施行した1例,
第21回日本呼吸器内視鏡学会中国四国支部会, 2013年2月. 高井ちか子, 中川靖士, 大岩由香里, 藤田結衣, 滝沢宏光, 吉田光輝, 川上行奎, 梶浦耕一郎, 先山正二, 丹黒章, 高浜洋介, 近藤和也 :
ヒト胸腺・胸腺腫における皮質・髄質 component の distribution,
第32回日本胸腺研究会, 2013年2月. 松井尚子, 大東いずみ, 近藤和也, 高浜洋介, 梶龍兒 :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第32回日本胸腺研究会, 2013年2月. 板東孝枝, 雄西智惠美, 今井芳枝, 市原多香子, 近藤和也 :
手術室見学入室方法別にみた学生の手術室見学実習での見学内容の実態,
第33回日本看護科学学会学術集会講演集, Vol.1, No.1, 461, 2012年12月. 梶浦耕一郎, 滝沢宏光, 近藤和也, 池田真由美, 古川尊子, 西野豪志, 後藤正和, 山本洋太, 古北由仁, 森本雅美, 吉田光輝, 中川靖士, 川上行奎, 先山正二, 丹黒章 :
周術期に骨髄異形成症候群を発症した肺小細胞癌の1例,
第74回日本臨床外科学会総会, 2012年11月. 西野豪志, 滝沢宏光, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
進行肺癌に合併した難治性続発性気胸に対する胸腔内フィブリン糊注入療法の有用性,
第74回日本臨床外科学会総会, 2012年11月. 梶浦耕一郎, 滝沢宏光, 森本雅美, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也 :
GPS(Glasgow Prognstic Score)を用いた肺癌手術症例の予後検討,
第53回日本肺癌学会総会, 2012年11月. 吉田光輝, 先山正二, 森本雅美, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
非連続性多発性腫瘤を呈した悪性胸膜中皮腫の1手術例,
第53回日本肺癌学会総会, 2012年11月. 田岡真理子, 広瀬敏幸, 住友正幸, 松岡永, 葉久貴司, 米田和夫, 稲山真美, 川上行奎, 中川靖士, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
肺硬化性血管腫の4例,
第53回日本肺癌学会総会, 2012年11月. 坂本晋一, 梶浦耕一郎, 滝沢宏光, 中川靖士, 森本雅美, 吉田光輝, 川上行奎, 先山正二, 近藤和也 :
Erlotinibにて術前導入療法した左肺癌の1手術例,
第53回日本肺癌学会総会, 2012年11月. 川上行奎, 先山正二, 滝沢宏光, 近藤和也, 丹黒章, 広瀬敏幸, 住友正幸, 三好孝典, 石倉久嗣, 木村秀, 監﨑孝一郎, 吉澤潔, 谷田信行, 浜口伸正, 日野弘之, 福本泰三 :
当院および関連7施設から集計した肺多形癌手術例の臨床的検討,
第53回日本肺癌学会総会, 2012年11月. 滝沢宏光, 近藤和也, 石倉久嗣, 木村秀, 坂本晋一, 宮本佳美, 森本雅美, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
非小細胞肺癌完全切除例に対するS-1術後補助化学療法の遺伝子発現解析による効果・予後予測因子の検討,
第53回日本肺癌学会総会, 2012年11月. 宮本佳美, 滝沢宏光, 近藤和也, 石倉久嗣, 木村秀, 坂本晋一, 森本雅美, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
非小細胞肺癌完全切除例に対するS-1術後補助化学療法の投与完遂性に関する検討,
第53回日本肺癌学会総会, 2012年11月. 滝沢宏光, 近藤和也, 西野豪志, 森本雅美, 梶浦耕一郎, 武知浩和, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
肺腺癌術後再発症例に対するEGFR-TKI投与の位置づけに関する検討,
第65回日本胸部外科学会定期学術集会, 2012年10月. 梶浦耕一郎, 滝沢宏光, 森本雅美, 西野豪志, 古北由仁, 山本洋太, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
自家蛍光による肺癌胸膜浸潤評価の可能性,
第65回日本胸部外科学会定期学術集会, 2012年10月. 梶浦耕一郎, 滝沢宏光, 鳥羽博明, 森本雅美, 西野豪志, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
触知不能肺腫瘍に対する術前細径気管支鏡下コイルマーキングの有用性と安全性,
第65回日本胸部外科学会定期学術集会, 2012年10月. 松井尚子, 大東いずみ, 近藤和也, 野村芳子, 高浜洋介, 梶龍兒 :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会学術集会, 2012年9月. 松井尚子, 大東いずみ, 近藤和也, 野村芳子, 高浜洋介, 梶龍兒 :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会, 2012年9月. 武知浩和, 森本雅美, 西野豪志, 梶浦耕一郎, 中川靖士, 川上行奎, 滝沢宏光, 吉田光輝, 先山正二, 近藤和也, 丹黒章 :
診断に難渋したゲフィチニブ投与中に発生した肺癌術後脳転移の1症例,
第47回日本呼吸器学会中国・四国地方会/第51回日本肺癌学会中国・四国支部会, 2012年7月. 梶浦耕一郎, 先山正二, 森本雅美, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
Lung pointとBf-Naviの気管支自動認識能の検討,
第35回日本呼吸器内視鏡学会学術集会, 2012年5月. 先山正二, 川上行奎, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
当科におけるmulti-modality methodによる気管支鏡教育-特に技能評価方法の実際について-,
第35回日本呼吸器内視鏡学会学術集会, 2012年5月. 吉田光輝, 近藤和也, 中川靖士, 森本雅美, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章, 横石道寛 :
重症筋無力症患者の術前3D画像による拡大胸腺摘出術後の予後予測の検討,
第29回日本呼吸器外科学会総会, 2012年5月. 森本雅美, 滝沢宏光, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
進行浸潤型胸腺腫に対するCAMP療法の有用性,
第29回日本呼吸器外科学会総会, 2012年5月. 近藤和也, 川原有貴, 高井チカ子, 藤田結衣, 大岩由香理, 滝沢宏光, 中川靖士, 梶浦耕一郎, 川上行奎, 吉田光輝, 監﨑孝一郎, 先山正二, 丹黒章 :
肺腺癌における遺伝子不安定性のマーカーとしてのヒストン蛋白γH2AXの発現,
第29回日本呼吸器外科学会総会, 2012年5月. 梶浦耕一郎, 先山正二, 滝沢宏光, 森本雅美, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 近藤和也 :
術前NLR(neutrophil-to-lymphocyte ratio)は非小細胞肺癌の予後予測因子となる,
第29回日本呼吸器外科学会総会, 2012年5月. 先山正二, 監﨑孝一郎, 鳥羽博明, 宇山攻, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺の再生・修復を目的とした胎生期肺組織移植,
第29回日本呼吸器外科学会総会, 2012年5月. 滝沢宏光, 近藤和也, 松岡永, 森本雅美, 梶浦耕一郎, 鳥羽博明, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
術前CTリンパ管造影と術中ICG蛍光法による肺癌センチネルリンパ節同定法の確立,
第29回日本呼吸器外科学会総会, 2012年5月. 中村真由美, 青木圭子, 中瀬勝則, 近藤和也, 奥田紀久子 :
徳島県医師会の禁煙活動の取り組みの現状と今後の課題,
第6回日本禁煙科学会学術集会in沖縄, 2011年11月. 青木圭子, 中村真由美, 川島周, 近藤和也, 藤井智惠子, 奥田紀久子 :
徳島県の学校園における防煙教育等に関する学校医の意識と実態,
第6回日本禁煙科学会学術総会in沖縄, 2011年11月.

(キーワード): 防煙教育 / 学校医

奥田紀久子, 藤井智惠子, 近藤和也, 宮﨑久美子, 梶原京子 :
徳島県の小・中学校における防煙教育の効果の実態と影響要因,
第6回日本禁煙科学会学術総会in沖縄, 2011年11月. 宮﨑久美子, 奥田紀久子, 近藤和也, 梶原京子, 藤井智惠子 :
喫煙防止教育講演後の高校生の喫煙に対する意識・態度の変容について,
第6回日本禁煙科学会学術総会in沖縄, 2011年11月. 梶浦耕一郎, 先山正二, 鳥羽博明, 森本雅美, 湊拓也, 後藤正和, 古北由仁, 山本洋太, 川上行奎, 中川靖士, 吉田光輝, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
3回にわたる頚部縦隔胸腔ドレナージ術施行し救命しえた降下性壊死性縦隔炎の1例,
第73回日本臨床外科学会総会, 2011年11月. 監﨑孝一郎, 先山正二, 鳥羽博明, 森本雅美, 梶浦耕一郎, 宇山攻, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
突発性と手術後気胸に対するフィブリン糊大量胸腔内注入療法の比較検討,
第73回日本臨床外科学会総会, 2011年11月. 梶浦耕一郎, 先山正二, 鳥羽博明, 宇山攻, 中川靖士, 吉田光輝, 滝沢宏光, 川上行奎, 監﨑孝一郎, 近藤和也, 丹黒章 :
胸腺腫摘出後に再生不良性貧血を発症した1例,
第52回日本肺癌学会総会, 2011年11月. 白石真理子, 近藤和也, 岩佐裕介, 藤田結衣, 大岩由香里, 高井チカ子, 滝沢宏光, 中川靖士, 鳥羽博明, 川上行奎, 梶浦耕一郎, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム酸塩に暴露したヒト肺癌におけるdsDNAの切断を修復するDNA修復遺伝子の異常の検討,
第52回日本肺癌学会総会, 2011年11月. 吉田光輝, 先山正二, 日野弘之, 森本雅美, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 近藤和也, 丹黒章 :
胸腔内の解剖学的破格を伴った肺癌手術症例の検討,
第52回日本肺癌学会総会, 2011年11月. 森本雅美, 滝沢宏光, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺腺癌手術検体を用いたCycleave-PCR法とPNA-LNA PCR-Clamp法のEGFR遺伝子変異測定結果の比較,
第52回日本肺癌学会総会, 2011年11月. 佐土原洋平, 鳥羽博明, 近藤和也, 梶浦耕一郎, 中川靖士, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍のFDG-PET/CT所見とHIF-1α，Glut-1，VEGFの発現との関連性,
第52回日本肺癌学会総会, 2011年11月. 近藤和也 :
《ワークショップ3》胸腺上皮性腫瘍におけるTNM staging system,
第52回日本肺癌学会総会, 2011年11月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺葉切除術後の残存肺の容積変化と術後呼吸機能についての検討,
第64回日本胸部外科学会定期学術集会, 2011年10月. 滝沢宏光, 鳥羽博明, 梶浦耕一郎, 森本雅美, 宇山攻, 中川靖士, 吉田光輝, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
経気管支水溶性造影剤注入によるCTリンパ管造影-区域切除におけるSentinel node navigation surgeryに向けて,
第64回日本胸部外科学会定期学術集会, 2011年10月. 今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する認識,
第19回日本乳癌学会学術総会, 439, 2011年9月. 今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する認識,
439, 2011年9月. 鳥羽博明, 先山正二, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
自家蛍光気管支鏡(SAFE-3000/AFI)の同時使用経験,
第34回日本呼吸器内視鏡学会学術集会, 2011年6月. 梶浦耕一郎, 鳥羽博明, 先山正二, 高嶋美佳, 湊拓也, 宇山攻, 滝沢宏光, 監﨑孝一郎, 川上行奎, 近藤和也, 丹黒章 :
当科におけるVBN併用極細径気管支鏡下肺生検の成績,
第34回日本呼吸器内視鏡学会学術集会, 2011年6月. 生島仁史, 工藤隆治, 古谷俊介, 川中崇, 久保亜貴子, 近藤和也 :
胸腺腫の放射線治療,
第115回日本医学放射線学会中国・四国地方会, 2011年5月. 滝沢宏光, 近藤和也, 鳥羽博明, 梶浦耕一郎, 高嶋美佳, 湊拓也, 宇山攻, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
経気管支水溶性造影剤注入によるCTリンパ管造影-区域切除における術前センチネル,
第111回日本外科学会定期学術集会, 2011年5月. 武知浩和, 池田真由美, 三崎万理子, 高嶋美佳, 兼松美幸, 湊拓也, 中川美砂子, 梶浦耕一郎, 古北由仁, 山本洋太, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
女性外科医の働きやすい現場を目指して,
第111回日本外科学会定期学術集会, 2011年5月. 兼松美幸, 滝沢宏光, 近藤和也, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
NSCLC完全切除例に対するS-1療法とweekly PTX+CBDCA併用療法の比較検討,
第28回日本呼吸器外科学会総会, 2011年5月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺葉切除術前後における肺の容積変化についての検討,
第28回日本呼吸器外科学会総会, 2011年5月. 高嶋美佳, 滝沢宏光, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肺癌との鑑別が困難であった結節性リンパ組織過形成の2切除例,
第28回日本呼吸器外科学会総会, 2011年5月. 梶浦耕一郎, 高嶋美佳, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 中川靖士, 川上行奎, 宇山攻, 先山正二, 近藤和也, 丹黒章 :
肺癌手術時の胸腔内洗浄細胞診陽性症例の検討,
第28回日本呼吸器外科学会総会, 2011年5月. 監﨑孝一郎, 先山正二, 鳥羽博明, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
気胸に対するフィブリン糊大量胸腔内注入療法の検討,
第28回日本呼吸器外科学会総会, 2011年5月. 鳥羽博明, 先山正二, 高嶋美佳, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
肺癌術後のフォローアップにPET/CTは有用か,
第28回日本呼吸器外科学会総会, 2011年5月. 近藤和也, 名村寿章, 藤田結衣, 高井チカ子, 大岩由香理, 滝沢宏光, 中川靖士, 鳥羽博明, 梶浦耕一郎, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍におけるDNA修復遺伝子MGMTのDNAメチル化と蛋白発現,
第28回日本呼吸器外科学会総会, 2011年5月. 棟方百熊, 中瀬勝則, 奥田紀久子, 廣原紀恵, 青木圭子, 中村真由美, 藤井智惠子, 大塚明廣, 山田進一, 佐藤純子, 近藤和也, 郷木義子 :
高校生の喫煙に関する認識に対する家族の影響,
第5回日本禁煙科学会学術総会, 2010年11月. 近藤和也 :
肺がんと喫煙(職場における喫煙対策を含めて),
第5回日本禁煙科学会学術総会, 2010年11月. 奥田紀久子, 青木圭子, 中村真由美, 棟方百熊, 藤井智惠子, 廣原紀恵, 大塚明廣, 中瀬勝則, 山田進一, 佐藤純子, 近藤和也, 郷木義子 :
徳島県の小・中・高等学校等における防煙教育および防煙対策の実態,
第5回日本禁煙科学会学術総会, 2010年11月. 廣原紀恵, 奥田紀久子, 青木圭子, 中村真由美, 山田進一, 中瀬勝則, 郷木義子, 藤井智惠子, 棟方百熊, 近藤和也 :
小学生への防煙教育の効果及び家族の喫煙に関する実態調査,
第5回日本禁煙科学会学術総会, 2010年11月. 滝沢宏光, 近藤和也, 鳥羽博明, 梶浦耕一郎, 宇山攻, 中川靖士, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
呼吸器領域におけるレーザー診断・治療の現況と展望,
第31回日本レーザー医学会総会, 2010年11月. 藤田結衣, 近藤和也, Hamed Ali Abdellah Khalil, 名村寿章, 仙波義貴, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム工場従事者におけるlung cancer susceptibilityの解析,
第51回日本肺癌学会総会, 2010年11月. 近藤和也, Hamed Ali Abdellah Khalil, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム酸塩に暴露した労働者に発生した肺癌における癌関連遺伝子の異常,
第51回日本肺癌学会総会, 2010年11月. 鳥羽博明, 先山正二, 監﨑孝一郎, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胎仔肺組織移植により移植したグラフト内でのTTF-1発現の検討,
第63回日本胸部外科学会定期学術集会, 2010年10月. 滝沢宏光, Khalil Harmed Abdellah, 近藤和也, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 柿内聡司, 曽根三郎, 丹黒章 :
5-アミノレブリン酸を用いた胸膜悪性腫瘍の蛍光診断,
第63回日本胸部外科学会定期学術集会, 2010年10月. 近藤和也, ハーメド・カーリル・アリアブデラ, 名村寿章, 仙波義貴, 滝沢宏光, 中川靖士, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
クロム工場労働者の肺がんにおける癌抑制遺伝子のDNAメチル化,
第69回日本癌学会学術総会, 2010年9月. 滝沢宏光, Khalil Harmed Abdellah, 近藤和也, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 柿内聡司, 曽根三郎, 丹黒章 :
5-アミノレブリン酸を用いた胸膜悪性腫瘍の蛍光診断,
第20回日本光線力学学会学術講演会, 2010年6月. 鳥羽和佳奈, 鳥羽博明, 木村久美, 澤井真由美, 大西節子, 久米博子, 近藤和也 :
徳島大学病院におけるDPC適合型肺がん手術クリティカルパスのバリアンス分析と改訂,
第12回日本医療マネジメント学会学術総会, 2010年6月. 河南真吾, 監﨑孝一郎, 鳥羽博明, 森本雅美, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
巨大気腫性肺嚢胞に対して嚢胞内ドレナージ後に気管支塞栓術+フィブリン糊嚢胞内注入により治療した1例,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 鳥羽博明, 先山正二, 兼松美幸, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
CT所見から見た小型末梢肺病変に対する極細径気管支鏡を用いたCTガイド下肺生検の適応の再構築,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 兼松美幸, 鳥羽博明, 先山正二, 三好孝典, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
小型末梢肺病変に対するVBN併用下CTガイド下気管支鏡下コイルマーキング,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. Abdellah Hamed, 鳥羽博明, 先山正二, 山本良, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
Holter ECG Monitoring of Sympathovagal Fluctuations During Bronchoscopy,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
当科におけるmulti-modality methodを用いた気管支鏡検査の教育方法,
第33回日本呼吸器内視鏡学会学術集会, 2010年6月. 森本雅美, 鳥羽博明, 先山正二, 兼松美幸, 藤原聡史, 井上聖也, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
多中心性に発生したと考えられた同時性多発胸腺腫の1例,
第27回日本呼吸器外科学会総会, 2010年5月. 兼松美幸, 高嶋美佳, 森本雅美, 井上聖也, 藤原聡史, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
非小細胞肺癌に対する術後補助療法としてのweekly paclitaxel+carboplatin(wTJ)併用療法の検討,
第27回日本呼吸器外科学会総会, 2010年5月. 川田祐子, 滝沢宏光, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 近藤和也, 島田光生, 丹黒章 :
先天性心膜欠損を合併した肺嚢胞症の一切除例,
第27回日本呼吸器外科学会総会, 2010年5月. 高嶋美佳, 鳥羽博明, 監﨑孝一郎, 森本雅美, 兼松美幸, 中川靖士, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
当科における肺動静脈瘻手術症例の臨床的検討,
第27回日本呼吸器外科学会総会, 2010年5月. 鳥羽博明, 近藤和也, 滝沢宏光, 高嶋美佳, 森本雅美, 兼松美幸, 中川靖士, 監﨑孝一郎, 先山正二, 丹黒章 :
肺癌術後再発症例の検討,
第27回日本呼吸器外科学会総会, 2010年5月. 澤田徹, 滝沢宏光, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
CT画像を用いた右上葉切除術前および術後の肺容積の変化についての検討,
第27回日本呼吸器外科学会総会, 2010年5月. 監﨑孝一郎, 生島仁史, 近藤和也, 鳥羽博明, 中川靖士, 滝沢宏光, 先山正二, 丹黒章 :
原発性肺癌Ⅰ期における消極的肺部分切除と定位放射線治療との比較,
第27回日本呼吸器外科学会総会, 2010年5月. 先山正二, 監﨑孝一郎, 鳥羽博明, Khasag Narmisheekh, 宇山攻, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
豚を用いた胎生期肺組織移植の実験的検討-ラットで得られた知見との比較を含めて-,
第27回日本呼吸器外科学会総会, 2010年5月. 近藤和也, 張真弓, 田所由紀子, 仙波義貴, 中川靖士, 滝沢宏光, 鳥羽博明, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺上皮性腫瘍の発生におけるDNA修復遺伝子MGMTの関連性,
第27回日本呼吸器外科学会総会, 2010年5月. 富本英樹, 後東久嗣, 柿内聡司, 多田浩也, 西岡安彦, 兼松貴則, 近藤和也, 先山正二, 葉久貴司, 米田和夫, 坂東弘康, 住友正幸, 曽根三郎 :
徳島県内における肺癌患者の疫学調査についての検討,
第50回日本呼吸器学会学術講演会, 2010年4月. Koichiro Kenzaki, Shoji Sakiyama, 宇山攻, Hiroaki Toba, Yasushi Nakagawa, Hiromitsu Takizawa, Kazuya Kondo and Akira Tangoku :
Sex-mismatchを用いたラット胎仔肺移植モデルのドナー細胞の組織学的検討,
第110回日本外科学会定期学術集会, Apr. 2010. 中川靖士, 近藤和也, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺癌44例の検討,
第110回日本外科学会定期学術集会, 2010年4月. 滝沢宏光, 近藤和也, Abdellah Khalil Hamed, 松岡永, 鳥羽博明, 中川靖士, 監﨑孝一郎, 先山正二, 丹黒章 :
光感受性物質を用いた胸膜悪性腫瘍の蛍光診断-SCIDマウスヒト肺癌胸膜播種モデルを用いた実験-,
第110回日本外科学会定期学術集会, 2010年4月. 先山正二, 監﨑孝一郎, 鳥羽博明, Khasag Narmisheekh, 宇山攻, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
豚を用いた胎生期肺組織移植の実験的検討,
第110回日本外科学会定期学術集会, 2010年4月. Narmisheekh Khasag, 先山正二, 鳥羽博明, 中川靖士, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
肺癌手術における呼気中一酸化および二酸化炭素モニタリング,
第110回日本外科学会定期学術集会, 2010年4月. 宇山攻, 先山正二, 松岡永, 鳥羽博明, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
非結核性抗酸菌症手術症例の検討,
第110回日本外科学会定期学術集会, 2010年4月. 三好孝典, 近藤和也, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二, 丹黒章 :
OR8-3 当科における光線力療法の治療経験ーporfimer sodiumからtalaporfin sodiumへー,
第128回日本呼吸器内視鏡学会総会, 2005年6月. 三好孝典, 近藤和也, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二, 丹黒章 :
O-090 抹消型微小肺癌に対する術前マーキングによる縮小手術の可能性,
第22回日本呼吸器外科学会総会, Vol.1997, No.3, 201, 2005年6月. 三好孝典, 近藤和也, 中川靖士, 長尾妙子, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二 :
PO202-8 非小細胞肺癌におけるthymidylate synthase(TS)とdihydropyrimidine dehydrogenase(DPD)の蛋白発現と活性,
第105回日本外科学会的学術集会, Vol.106, No.2, 378, 2005年5月. 近藤正, 上野淳二, 近藤和也 :
最適なネットワーク構造を自己選択する改良形GMDH-typeニューラルネットワークによる医用画像認識,
第32回知能システムシンポジューム論文集, 33-36, 2005年3月.

(キーワード): ニューラルネットワーク (neural network) / 医療情報学 (medical infomatics)

三好孝典, 近藤和也, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 先山正二 :
pP4-42 pN2肺癌切除例の予後因子の検討,
第45回日本肺癌学会総会, 481, 2004年10月. 三好孝典, 近藤和也, 長尾妙子, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 澤田成彦, 先山正二, 門田康正 :
OR1-5 肺抹消微小節に対する術前CTガイドによる気管支鏡下マーキング,
第27回日本呼吸器内視鏡学会総会, 242, 2004年6月. 三好孝典, 近藤和也, 長尾妙子, 滝沢宏光, 監﨑孝一郎, 藤野晴彦, 澤田成彦, 先山正二, 門田康正 :
P-221 当科における気管支形成手術症例の検討,
第21回日本呼吸器外科学会総会, 222, 2004年5月. 三好孝典, 近藤和也, 長尾妙子, 滝沢宏光, 藤野晴彦, 澤田成彦, 先山正二, 露口勝, 木村秀, 住友正幸, 門田康正 :
SF-079-1 非小細胞肺癌におけるthymidylate synthase(TS)とdihydropyrimidine dehydrogenase(DPD)の臨床学的意義,
第104回日本外科学会定期学術集会, 281, 2004年4月. 三好孝典, 近藤和也, 長尾妙子, 滝沢宏光, 監﨑孝一郎, 澤田成彦, 藤野晴彦, 先山正二, 門田康正 :
LP1-39 上大静脈(腕頭静脈)合併削除·再建を行った胸腺原発前縦隔腫瘍切除例の臨床学的検討,
第56回日本胸部外科学会総会, Vol.51, 391, 2003年11月. 三好孝典, 近藤和也, 藤野晴彦, 高橋裕児, 先山正二, 沖津宏, 門田康正 :
P-126 術後UFT投与された非小細胞肺癌患者におけるTS.DPD蛋白の発現と予後との関連性,
第20回日本呼吸器外科学会総会, 212, 2003年5月. 三好孝典, 近藤和也, 藤野晴彦, 高橋裕児, 澤田成彦, 先山正二, 沖津宏, 露口勝, 木村秀, 住友正幸, 門田康正 :
E-70 非小細胞肺癌におけるthymidylalte synthase(TS)とdihydropyimidine dehydrogenase(DPD)の発現と活性,
第43回日本肺癌学会総会, 409, 2002年11月. 加藤昭二, 橋本一郎, 中西秀樹, 荒瀬誠治, 近藤和也, 住友正幸 :
術後肺塞栓を起こした骨外性粘液型軟骨肉腫の1例,
第93回日本皮膚科学会総会, 1994年4月.

研究会・報告書

松井尚子, 近藤和也, 和泉唯信, 大東いずみ :
正常ヒト胸腺を用いた胸腺上皮細胞のRNA シークエンス解析,
第43回日本胸腺研究会, 2024年2月. 竹内大平, 河北直也, 細川暉雄, 住友弘幸, 宮本直輝, 坂本晋一, 森下敦司, 鳥羽博明, 近藤和也, 滝沢宏光 :
左B1+2転位気管支を伴い肺癌に対して胸腔鏡下肺区域切除術を施行した1例,
第32回日本呼吸器内視鏡学会中国四国支部会, 2023年12月. 森下敦司, 河北直也, 細川暉雄, 竹内大平, 住友弘幸, 宮本直輝, 坂本晋一, 鳥羽博明, 近藤和也, 滝沢宏光 :
Cone-beam CT由来Augmented Fluoroscopyを用いた気管支鏡下生検,
第32回日本呼吸器内視鏡学会中国四国支部会, 2023年12月. 住友弘幸, 鳥羽博明, 細川暉雄, 竹内大平, 髙杉遥, 坂本晋一, 宮本直輝, 森下敦司, 河北直也, 近藤和也, 滝沢宏光 :
小型末梢肺病変に対する，Cone-beam CTを用いた気管支鏡下コイルマーキング,
第32回日本呼吸器内視鏡学会中国四国支部会, 2023年12月. 髙嶋美佳, 井﨑富由実, 竹内大平, 坂本晋一, 住友弘幸, 宮本直輝, 河北直也, 鳥羽博明, 川上行奎, 近藤和也, 滝沢宏光 :
左腕頭静脈合併切除を伴う拡大胸腺摘出術後に静脈内に血栓形成を認めた1例,
第6回徳島外科医会, 2023年2月. 髙嶋美佳, 鳥羽博明, 坂本晋一, 宮本直輝, 井上聖也, 河北直也, 藤原聡史, 後藤正和, 吉田卓弘, 清家純一, 川上行奎, 近藤和也, 滝沢宏光 :
進行食道癌による気道のEmergencyに対する気道ステント留置例の検討,
第5回徳島外科医会, 2022年2月. 宮本直輝, 吉田光輝, 大塚憲司, 髙嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 近藤和也, 西岡安彦, 滝沢宏光, 丹黒章 :
胸腔鏡下に確定診断を得たCalcifying fibrous tumorの1例,
第4回徳島外科医会, 2021年2月. 坂本晋一, 滝沢宏光, 山本清成, 宮本直輝, 髙嶋美佳, 松本大資, 河北直也, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
左B1+2転位気管支とV1+2の走行異常を認める左下葉肺癌の一切除例,
第4回徳島外科医会, 2021年2月. 庄野隆志, 滝沢宏光, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 髙嶋美佳, 松本大資, 河北直也, 吉田光輝, 鳥羽博明, 川上行奎, 近藤和也, 丹黒章 :
網膜芽細胞腫治療後に縦隔鏡に発生した平滑筋肉腫の一例,
第4回徳島外科医会, 2021年2月. 松井尚子, 山本遥平, 大東いずみ, 近藤和也, 和泉唯信 :
重症筋無力症患者の胸腺ではプラズマブラストが増加している,
第40回日本胸腺研究会, 2021年2月. 牧秀則, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 宮本直輝, 坂本晋一, 松本大資, 髙嶋美佳, 河北直也, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
微小肺病変に対して術中Cone-beam CT併用気管支鏡下コイルマーキングが有用であった1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 南城和正, 河北直也, 吉田光輝, 庄野隆志, 山本清成, 牧秀則, 坂本晋一, 宮本直輝, 髙嶋美佳, 松本大資, 鳥羽博明, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
肺アミロイドーシスを伴った上皮内肺腺癌の1例,
第261回徳島医学会学術集会(Web配信), 2020年8月. 鳥羽博明, 滝沢宏光, 庄野隆志, 南城和正, 山本清成, 牧秀則, 乾友浩, 坂本晋一, 宮本直輝, 笹聡一郎, 青山万理子, 井上寛章, 髙嶋美佳, 松本大資, 井上聖也, 河北直也, 後藤正和, 西野豪志, 奥村和正, 吉田卓弘, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
より良いがんの地域連携体制構築のための取り組み,
第261回徳島医学会学術集会(Web配信), 2020年8月. 鈴木由衣, 板東孝枝, 近藤和也, 今井芳枝, 髙橋亜希 :
手術室看護師のストレスに関する文献的概観,
2020年3月. 竹原恵美, 坪井光弘, 滝沢宏光, 溝渕海, 宮本直輝, 高嶋美佳, 松本大資, 河北直也, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也 :
呼吸器外科領域における後期研修医修練，大学2年間での経験と理想について,
第3回徳島外科医会, 2020年2月. 滝沢宏光, 鳥羽博明, 松本大資, 高嶋美佳, 竹原恵美, 宮本直輝, 河北直也, 坪井光弘, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
チームで行う3Dモデルを用いたロボット支援胸腔鏡下肺葉切除のシミュレーション,
第34回四国内視鏡外科研究会, 2020年2月. 松本大資, 滝沢宏光, 鈴木恵美, 山田亮, 高嶋美佳, 河北直也, 澤田徹, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 近藤和也, 丹黒章 :
触知困難小型肺病変をコイルと色素を用いたマーキング法で切除した1例,
第33回四国内視鏡外科研究会, 2019年2月. 鈴木恵美, 高嶋美佳, 鳥羽博明, 松本大資, 森本雅美, 河北直也, 澤田徹, 坪井光弘, 武知浩和, 川上行奎, 滝沢宏光, 吉田光輝, 近藤和也, 丹黒章 :
放射線皮膚潰瘍・胸骨骨髄炎に対し広汎骨性胸郭切除を行った乳癌再発の1例,
第2回徳島外科医会, 2019年2月. 山田亮, 松本大資, 高嶋美佳, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 吉田光輝, 滝沢宏光, 近藤和也, 丹黒章 :
術前化学放射線療法後Transmanubrial approach(TMA)で完全切除が可能であったPancoast腫瘍の1例,
第2回徳島外科医会, 2019年2月. 吉田光輝, 近藤和也, 湯浅将生, 池光大貴, 澤田徹, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
拡大胸腺摘出術における術式の比較検討,
第38回日本胸腺研究会, 2019年2月. 澤田徹, 近藤和也, 松井尚子, 鈴木恵美, 山田亮, 高嶋美佳, 松本大資, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 丹黒章 :
当院におけるMGに対する拡大胸腺摘出術後の予後成績,
第38回日本胸腺研究会, 2019年2月. 副島志帆, 岸渕麗奈, 六車京香, 坪井光弘, 梶浦耕一郎, 澤田徹, 滝沢宏光, 近藤和也 :
胸腺上皮性腫瘍の悪性度と7つの遺伝子におけるDNAメチル化の関係,
第38回日本胸腺研究会, 2019年2月. 松井尚子, 大東いずみ, 山本遥平, 中川英刀, 近藤和也, 高浜洋介 :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第37回日本胸腺研究会, 2018年2月. 吉田光輝, 近藤和也, 澤田徹, 河北直也, 坪井光弘, 鳥羽博明, 川上行奎, 滝沢宏光, 丹黒章 :
組織診断に苦慮した前縦隔腫瘍の1切除例,
第37回日本胸腺研究会, 2018年2月. 澤田徹, 滝沢宏光, 河北直也, 坪井光弘, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 丹黒章 :
肝細胞癌肺転移に対してICG蛍光観察下に胸腔鏡下肺部分切除術を行った1例,
第32回四国内視鏡外科研究会, 2018年2月. 松井尚子, 大東いずみ, 中川英刀, 近藤和也, 高浜洋介 :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第36回日本胸腺研究会, 2017年2月. Wusiman Nuliamina, 近藤和也, 梶浦耕一郎, 坪井光弘, 岸渕麗奈, 鳥羽博明, 河北直也, 澤田徹, 川上行奎, 吉田光輝, 滝沢宏光, 丹黒章 :
胸腺上皮性腫瘍におけるGAD1(glutamic acid decarboxylase 1)遺伝子プロモーター領域のDNAメチル化,
第36回日本胸腺研究会, 2017年2月. 河北直也, 近藤和也, 鳥羽博明, 坪井光弘, 梶浦耕一郎, 吉田光輝, 滝沢宏光 :
血管内発育と同時性肺転移を認めたA型胸腺腫の1例,
第36回日本胸腺研究会, 2017年2月. 近藤和也 :
《特別講演Ⅱ》胸腺腫・胸腺癌の最新話題,
第66回Y.L.セミナー, 2016年9月. 近藤和也 :
胸腺腫・胸腺癌の最新話題,
第66回Y.L.セミナー, 2016年9月. 乾友浩, 松本大資, 髙杉遥, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 先山正二, 丹黒章 :
術後乳糜胸により診断し得た縦隔内胸管嚢胞の1例,
第24回徳島外科術後管理研究会, 2016年2月. 松井尚子, 大東いずみ, 中川靖士, 近藤和也, 高浜洋介 :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, 39, 2016年2月. 酒井和香, 松井尚子, 近藤和也 :
高齢発症MGの臨床像,
第35回日本胸腺研究会, 51, 2016年2月. 行重佐和香, 鳥羽博明, 川上行奎, 近藤和也, 河北直也, 坪井光弘, 梶浦耕一郎, 滝沢宏光, 先山正二, 丹黒章 :
肺犬糸状虫症の1切除例,
第251回徳島医学会学術集会, 2015年8月. 近藤和也 :
胸腺上皮性腫瘍の治療戦略‐up to date‐,
第2回呼吸器症例から学ぶ地域連携の会, 2015年3月. 梶浦耕一郎, 先山正二, 近藤和也, 坂本晋一, 住友弘幸, 坪井光弘, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 丹黒章 :
Autofluorescence imaging(AFI)にて陰性所見を呈した中枢型早期扁平上皮癌の1症例,
第23回日本呼吸器内視鏡学会中国四国支部会, 2015年2月. 梶浦耕一郎, 近藤和也, 森本友樹, 坪井光弘, 中川靖士, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺嚢胞と鑑別を要する腫瘍の大部分が嚢胞性変化を起こした胸腺腫の検討,
第34回日本胸腺研究会, 2015年2月. 梶浦耕一郎, 近藤和也, 森本友樹, 坪井光弘, 中川靖士, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸腺癌におけるRASSF1遺伝子のDNAメチル化はB3胸腺腫よりも高い,
第34回日本胸腺研究会, 2015年2月. 松井尚子, 大東いずみ, 中川靖士, 近藤和也, 高浜洋介 :
ヒト胸腺を用いた単一細胞解析への試み,
第34回日本胸腺研究会, 2015年2月. 今井芳枝, 中川美砂子, 滝本理沙, 近藤和也, 坂東孝枝, 雄西智惠美, 笹三徳, 田所由紀子, 丹黒章, 森恵子, 友竹正人, 髙尾正一郎, 上野淳二, 高橋雅子, 廣瀬千恵子, 久岡園花 :
ホルモン受容体陽性閉経後乳癌に対するアロマターゼ阻害(AI)剤投与前後の症状とQOLの変化,
第69回徳島乳腺研究会, 2014年4月. 森下敦司, 先山正二, 西野豪志, 坪井光弘, 梶浦耕一郎, 中川靖士, 滝沢宏光, 川上行奎, 近藤和也, 坂東良美 :
Organizing blood clotを伴った後縦隔腫瘍の1例,
第28回四国内視鏡外科研究会, 2014年2月. 坪井光弘, 森下敦司, 梶浦耕一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
当院におけるPowered ECHELON FLEXTMの使用経験,
第28回四国内視鏡外科研究会, 2014年2月. 松井尚子, 中川靖士, 近藤和也, 梶龍兒, 高浜洋介 :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第33回日本胸腺研究会, 2014年2月. 森下敦司, 近藤和也, 松井尚子, 坂東良美, 梶浦耕一郎, 滝沢宏光, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
重症筋無力症を伴った胸腺のmultiple microcystsの一例,
第33回日本胸腺研究会, 2014年2月. 中川靖士, 近藤和也, Mokhtar Mohamed, Ali Abdellah, 名村寿章, 梶浦耕一郎, 森本友樹, 高井チカ子, 滝沢宏光, 鳥羽博明, 吉田光輝, 川上行奎, 先山正二, 丹黒章 :
第33回日本胸腺研究会,
胸腺上皮性腫瘍におけるDNA修復遺伝子MGMTのメチル化と発現低下, 2014年2月. 松井尚子, 中川靖士, 近藤和也, 梶龍兒, 高浜洋介 :
第33回日本胸腺研究会,
重症筋無力症の過形成胸腺ではハッサル小体が増加している, 2014年2月. 梶龍兒, 松井尚子, 古川貴大, 近藤和也, 高浜洋介, 野村芳子 :
重症筋無力症の発症機序:過形成胸腺ではハッサル小体が増加している,
免疫性神経疾患に関する調査研究班(平成25年度), 2014年1月. 竹治友紀, 加古磨里子, 山室亜莉沙, 今井芳枝, 雄西智惠美, 近藤和也 :
がんと共に生きる中で前向きにあろうとするために患者自身が工夫していること,
第66回徳島乳腺研究会, 2013年5月. 滝沢宏光, 池田真由美, 古川尊子, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 先山正二, 近藤和也, 丹黒章 :
ICG蛍光内視鏡を用いた胸腔鏡下区域切除域,
第11回スプリングセミナー IN OKINAWA, 2013年3月. 西野豪志, 先山正二, 池田真由美, 森本雅美, 古川尊子, 梶浦耕一郎, 川上行奎, 吉田光輝, 滝沢宏光, 中川靖士, 近藤和也, 丹黒章 :
胸腔鏡手術を施行した月経随伴性気胸の2例,
第27回四国内視鏡外科研究会, 2013年2月. 高井ちか子, 中川靖士, 大岩由香理, 藤田結衣, 滝沢宏光, 吉田光輝, 川上行奎, 梶浦耕一郎, 先山正二, 丹黒章, 高浜洋介, 近藤和也 :
ヒト胸腺・胸腺腫における皮質・髄質componentのdistribution,
第32回日本胸腺研究会, 2013年2月. 吉田光輝, 近藤和也, 横石道寛, 中川靖士, 梶浦耕一郎, 鳥羽博明, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
症筋無力症患者の術前3D画像解析が拡大胸腺摘出術後の予後予測に及ぼす可能性,
第32回日本胸腺研究会, 2013年2月. 近藤和也 :
胸腺上皮性腫瘍データベース事業の報告,
第32回日本胸腺研究会, 2013年2月. 池田真由美, 西野豪志, 先山正二, 梶浦耕一郎, 中川靖士, 吉田光輝, 川上行奎, 滝沢宏光, 近藤和也, 丹黒章 :
胸腺腫術後に両側横隔神経麻痺による呼吸不全をきたした1例,
第21回徳島外科術後管理研究会, 2013年2月. 板東孝枝, 谷崎圭, 近間奈津美, 雄西智惠美, 近藤和也 :
乳房温存術後の乳房の変容に対する満足度,
徳島乳腺研究会抄録集, 2012年4月. 中川靖士, 近藤和也, 高浜洋介 :
マウス胸腺上皮細胞のマイクロアレイ解析によるヒト胸腺上皮性腫瘍解析法開発,
第31回日本胸腺研究会, 2012年2月. 川上行奎, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川靖士, 滝沢宏光, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
肝細胞癌術後肺転移に対するICG蛍光法による腫瘍検出の試み,
第16回中国四国内視鏡外科研究会, 2011年9月. 近藤和也 :
知って防ごう肺がん,
阿南市保健センター講演会, 2011年7月. 梶浦耕一郎, 滝沢宏光, 高嶋美佳, 宇山攻, 鳥羽博明, 川上行奎, 中川靖士, 吉田光輝, 監﨑孝一郎, 先山正二, 近藤和也, 丹黒章 :
多彩な陰影を呈した結節性リンパ組織過形成の3切除例,
第46回日本呼吸器学会中国・四国地方会第50回日本肺癌学会中国・四国支部会, 2011年7月. 多田亜沙香, 小西菜美, 板東孝枝, 雄西智惠美, 近藤和也 :
初めて乳房の手術を受け退院を控えた患者とその家族の今後の生活に対する意識の比較,
徳島乳腺研究会抄録集, 2011年4月. 今井芳枝, 中川美砂子, 雄西智惠美, 森恵子, 板東孝枝, 近藤和也, 丹黒章 :
外来通院中のリンパ浮腫未発症の乳がん術後患者のリンパ浮腫に対する実態調査,
第60回徳島乳腺研究会, 2011年4月. 兼松美幸, 滝沢宏光, 近藤和也, 池田真由美, 三崎万理子, 高嶋美佳, 湊拓也, 梶浦耕一郎, 宇山攻, 鳥羽博明, 中川美砂子, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
肺癌術後に肺動脈血栓塞栓症ならびにAcinetobacter baumannii敗血症を発症し，治療に難渋した1例,
第19回徳島外科術後管理研究会, 2011年2月. 名村寿章, 近藤和也, Ali Hamed Khalil Abdellah, 藤田結衣, 岩佐裕介, 仙波義貴, 大岩由香理, 高井チカ子, 中川靖士, 滝沢宏光, 鳥羽博明, 川上行奎, 監﨑孝一郎, 先山正二, 丹黒章 :
胸腺腫と胸腺癌におけるDNA修復遺伝子MGMT(O_6-methylguanine DNA methyltransferase)のメチル化,
第30回日本胸腺研究会, 2011年2月. 鳥羽博明, 先山正二, 高田香, 高嶋美佳, 梶浦耕一郎, 滝沢宏光, 監﨑孝一郎, 近藤和也, 丹黒章 :
摘出時にラリンジアルマスクが効果的であった小児気管支異物の1例,
第19回日本呼吸器内視鏡学会中国四国支部会, 2011年1月. 近藤和也 :
肺がん対策について,
平成22年度保健所技術職員スキルアップ研修事業「がん」に関する研修会, 2010年8月. 兼松美幸, 監﨑孝一郎, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 近藤和也, 丹黒章 :
迷入性縦隔内甲状腺腫の一例,
第45回日本呼吸器学会中国・四国地方会第49回日本肺癌学会中国・四国支部会, 2010年7月. 監﨑孝一郎, 近藤和也, 鳥羽博明, 中川靖士, 川上行奎, 滝沢宏光, 先山正二, 丹黒章 :
胸膜肺全摘術を施行した悪性胸膜中皮腫の臨床的検討,
第45回日本呼吸器学会中国・四国地方会第49回日本肺癌学会中国・四国支部会, 2010年7月. 高嶋美佳, 鳥羽博明, 先山正二, 藤原聡史, 兼松美幸, 中川靖士, 滝沢宏光, 近藤和也, 丹黒章 :
縦隔リンパ節転移を有する胸腺異型カルチノイドに対して集学的治療を行った1例,
第53回関西胸部外科学会学術集会, 2010年6月. Yuko Yasuhara, Hirokazu Ito, Tetsuya Tanioka, Kazuya Kondo and Rozzano De Castro Locsin :
Report on the Second International Seminar and Workshop on Technological Competency as Caring in the Health Sciences 2018,
The Journal of Medical Investigation : JMI, Vol.66, No.1,2, 54-57, Feb. 2019.

(要約): The Second International Seminar and Workshop (ISW) on Technological Competency as Caring in the Health Sciences was offered by the Rozzano Locsin Institute for Advancing the Theory of Technological Competency as Caring in Nursing, and held from August 17- 19, 2018 at Tokushima University in Tokushima,Japan. The ISW was envisioned to provide a platform for sharing research and scholarly works into innovative design and developments on studying and applying the theory of Technological Competency as Caring in the Health Sciences. This ISW was founded on the theory of Technological Competency as Caring in Nursing (TCCN) (Locsin, 2005). The ISW, as aimed broadened the influence of theory, research, and practice through the advancements in technology, caring, and nursing, as espoused in the theory of Technological Competency as Caring particularly within the Health Sciences. This report illuminates the contents of the ISW and its outcomes, and reveals the direction of the theory, its development, and future implications through formalized activities. J. Med. Invest. 66 : 54-57, February, 2019.
(キーワード): International Seminar and Workshop / ケアリング (caring) / 看護 (nursing) / Health sciences / Technological competency
(徳島大学機関リポジトリ): ● Metadata: 113321
(出版サイトへのリンク): ● Publication site (DOI): 10.2152/jmi.66.54
(文献検索サイトへのリンク): ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31064955; ● Search Scopus @ Elsevier (PMID): 31064955; ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.54

(徳島大学機関リポジトリ: 113321, DOI: 10.2152/jmi.66.54, PubMed: 31064955)

特許: 研究者総覧に該当データはありませんでした。
作品: 研究者総覧に該当データはありませんでした。
補助金・競争的資金: ピラティスを基盤とした肺がんリハビリテーションHope促進看護プログラムの開発 (研究課題/領域番号: 23K09931 )
網羅的なCpG siteのDNAメチル化の検索による肺腺癌のtumor suppressor geneの同定 (研究課題/領域番号: 23K08296 )
外来化学療法におけるPRO-CTCAEを活用した看護ケアモデルの構築 (研究課題/領域番号: 22K10831 )
自家蛍光顕微鏡画像を用いた肺腺癌浸潤AI予測モデル構築と術中診断への応用 (研究課題/領域番号: 21K08905 )
癌微小環境における免疫担当細胞の真の役割への探求－同所移植モデルの確立とともに－ (研究課題/領域番号: 21K08884 )
小中高校生の新型たばこに関する知識や関心等の実態解明と新たな喫煙防止教育の検討 (研究課題/領域番号: 20K10347 )
胸腺癌に対するエピジェネチックな診断と治療 (研究課題/領域番号: 20K09178 )
放射線治療効果を高精度に予測する分子イメージングレディオミクスモデルの開発 (研究課題/領域番号: 20K07698 )
肺癌同所性移植モデルを使用した癌微小環境の探求 (研究課題/領域番号: 19K09307 )
Hopeを強化した手術を受ける肺がん患者リハビリテーション看護ケアモデルの構築 (研究課題/領域番号: 18K10348 )
マウス肺移植による肺再生医療研究の可能性 (研究課題/領域番号: 17K10786 )
分子イメージングを用いた局所進行非小細胞肺癌に対する新規治療戦略 (研究課題/領域番号: 17K10479 )
Ｂ型胸腺腫を合併する重症筋無力症（ＭＧ）におけるＭＧ発症機序の解明 (研究課題/領域番号: 16K10684 )
肺癌の浸潤に伴う自家蛍光変化のメカニズム解明と術式選択への応用 (研究課題/領域番号: 16K10683 )
ＤＮＡメチル化からみた胸腺腫瘍の新規腫瘍関連遺伝子の検索 (研究課題/領域番号: 26462145 )
肺癌患者における術中胸膜浸潤の蛍光診断と胸膜下ルートを通るリンパ節転移の解明 (研究課題/領域番号: 25462178 )
肺癌同所性移植モデルと小動物用ＰＥＴ／ＣＴ装置を用いた抗癌剤効果予測分子の同定 (研究課題/領域番号: 24659634 )
徳島県における小・中学生を対象とした防煙教育プログラムの有効性に関する縦断的検証 (研究課題/領域番号: 23590743 )
非小細胞肺癌に対する術前導入化学放射線療法の分子生物学的効果に関する研究 (研究課題/領域番号: 22591386 )
クロム酸塩に暴露したヒト肺癌におけるDNA二本鎖切断を修復する遺伝子の異常の検討 (研究課題/領域番号: 21591815 )
ヒト肺癌同所性移植モデルにおける抗癌剤関連遺伝子変化に関する研究 (研究課題/領域番号: 18591552 )
吸入発癌物質・クロム酸塩の暴露による肺癌の発癌過程の解明-修復遺伝子hMLH1とgene instability- (研究課題/領域番号: 18591551 )
胎仔肺組織移植によるブレオマイシン誘導肺線維症修復の試み (研究課題/領域番号: 17591474 )
クロム工場従事者の気管支粘膜病変における遺伝子変化とクロム曝露量の関連性の研究 (研究課題/領域番号: 15591477 )
GMDH手法によるマルチスライスCTの気管支・肺血管情報に基づく肺区域の画像認識 (研究課題/領域番号: 15560349 )
肺癌手術検体よりの初代培養細胞による同所性移植SCIDマウスモデルの作成 (研究課題/領域番号: 14571269 )
虚血再潅流時の移植肺におけるERK上昇の機序とその意義についての検討 (研究課題/領域番号: 14571268 )
乳癌細胞のホルモン依存性喪失過程に伴う浸潤能の変化と低分子量G蛋白質の役割 (研究課題/領域番号: 13671239 )
5-FU関連酵素のアンチセンスDNAの導入によるヒト肺癌の5-FU治療効果 (研究課題/領域番号: 13671237 )
肺癌リンパ行性転移モデルによる癌細胞の転移能と転移抑制に関する研究 (研究課題/領域番号: 12671312 )
クロム酸塩暴露による癌発生ラットを利用しての中枢性肺扁平上皮癌の発生機序の解明 (研究課題/領域番号: 12470275 )
ヒト肺癌におけるリンパ行性転移とCD44との関連性についての研究 (研究課題/領域番号: 11671329 )
ヒト肺癌細胞株におけるメタロ・プロテナーゼ阻害剤BPHAの抗浸潤・転移効果の研究 (研究課題/領域番号: 11671328 )
マイクロキメリズム誘導と移植肺の慢性拒絶反応回避に関する研究 (研究課題/領域番号: 11671327 )
クロムの暴露によるヒト肺癌発生機序に関する研究-クロム暴露とgenomic instability- (研究課題/領域番号: 10470276 )
肺移植における抗T cell receptor Vβ抗体による免疫抑制療法 (研究課題/領域番号: 09671383 )
肺移植後の局所免疫に関する基礎的研究 (研究課題/領域番号: 08671531 )
ラット肺移植におけるサイトカイン発現の組織学的検討 (研究課題/領域番号: 07671478 )
正常肺および肺癌における接着分子CD44のスプライシングパターンの検討 (研究課題/領域番号: 07671477 )
クロムに曝露したヒト肺癌における発癌過程の分子生物学的解明 (研究課題/領域番号: 07457295 )
肺移植における拒絶反応モニタリング-浸潤リンパ球のT cell receptor Vβ geneの解析による- (研究課題/領域番号: 06454401 )
研究者番号（10263815）による検索

その他: 研究者総覧に該当データはありませんでした。

研究者総覧で最新データを確認する

2024年11月14日更新

専門分野・研究分野: 医学 (Medicine)
呼吸器外科 (Chest Surgery)
所属学会・所属協会: 日本呼吸器外科学会
日本肺癌学会
日本呼吸器内視鏡学会
日本胸部外科学会
日本胸腺研究会
日本外科学会
日本癌学会
日本癌治療学会
International association for the study of lung cancer
American Society of Clinical Oncology
American Association for Cancer Research
International Thymic Malignancy Interest Group
日本内視鏡外科学会
日本臨床外科学会
委員歴・役員歴: 日本呼吸器外科学会 (評議員 [2000年5月])
日本肺癌学会 (評議員 [2002年11月])
日本呼吸器内視鏡学会 (評議員 [2004年6月])
日本胸部外科学会 (評議員 [2008年10月])
日本胸腺研究会 (理事 [2005年2月])
International Thymic Malignancy Interest Group (Steering committee member [2010年5月])
受賞: 2001年3月, AACR(American Association for Cancer Research)-ITO EN, LTD. Scholar-in-Taining Award for Promising Cancer Research (American Association for Cancer Research)
活動: 徳島県 (肺がん部会部会長 [2005年2月])

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2024年11月10日更新

2024年11月9日更新

Ｊグローバル

Jグローバル最終確認日: 2024/11/9 01:21
氏名（漢字）: 近藤和也
氏名（フリガナ）: コンドウカズヤ
氏名（英字）: Kondo Kazuya
所属機関: 徳島大学教授

リサーチマップ

researchmap最終確認日: 2024/11/10 01:33
氏名（漢字）: 近藤和也
氏名（フリガナ）: コンドウカズヤ
氏名（英字）: Kondo Kazuya
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登録日時: 2011/1/20 00:00
更新日時: 2016/7/6 13:24
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所属ID: 0344001003
所属: 徳島大学
部署: 医学部保健学科徳島大学大学院ヘルスバイオサイエンス研究部臨床腫瘍医療学分野
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研究者番号: 10263815

所属（現在）: 2024/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授

所属（過去の研究課題 情報に基づく）*注記: 2018/4/1 – 2023/4/1 : 徳島大学, 大学院医歯薬学研究部(医学域), 教授
2016/4/1 – 2017/4/1 : 徳島大学, 大学院医歯薬学研究部(医学系), 教授
2015/4/1 – 2016/4/1 : 徳島大学, 大学院医歯薬学研究部, 教授
2011/4/1 – 2014/4/1 : 徳島大学, ヘルスバイオサイエンス研究部, 教授
2012/4/1 : 徳島大学, 大学院・ヘルスバイオサイエン研究部, 教授
2009/4/1 – 2011/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授
2007/4/1 : 徳島大学, 医学部, 教授
2006/4/1 : 徳島大学, 医学部・歯学部附属病院, 講師
2004/4/1 – 2005/4/1 : 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師
1999/4/1 – 2003/4/1 : 徳島大学, 医学部, 講師
1998/4/1 : 徳島大学, 医学部付属病院, 助手
1998/4/1 : 徳島大学, 医学部附属病院, 助手
1995/4/1 – 1997/4/1 : 徳島大学, 医学部・附属病院, 助手
1994/4/1 : 徳島大学, 医学部, 助手

審査区分/研究分野

研究代表者

医学 / 外科 / 胸部外科学
生物系 / 医歯薬学 / 外科系臨床医学 / 胸部外科学
医学 / 外科 / 外科学一般
生物系 / 医歯薬学 / 外科系臨床医学 / 呼吸器外科学
小区分55040:呼吸器外科学関連

研究代表者以外

医学 / 外科 / 胸部外科学
生物系 / 医歯薬学 / 内科系臨床医学 / 放射線科学
生物系 / 医歯薬学 / 社会医学 / 衛生学
生物系 / 医歯薬学 / 外科系臨床医学 / 呼吸器外科学
医学 / 外科 / 外科学一般
理工系 / 工学 / 電気電子工学 / システム工学
生物系 / 医歯薬学 / 外科系臨床医学 / 胸部外科学
小区分58060:臨床看護学関連
小区分55040:呼吸器外科学関連
小区分50020:腫瘍診断および治療学関連
小区分58010:医療管理学および医療系社会学関連

キーワード

研究代表者

RT-PCR法 / 非小細胞肺癌 / CD44 / 早期診断 / 気管支洗浄液 / Southern blotting法 / クロム肺癌 / microsatellite instability / DNA修復 / MRE11遺伝子 / mononucleotide repeat / 扁平上皮癌 / 職業性肺癌 / 肺癌 / クロム酸塩 / マイクロサテライト不安定性 / MRE11 / RAD50 / preclinical animal model / 同所性移植 / PET/CT / シスプラチン / メタロ・プロテナーゼ / 浸潤能 / BPHA / MM1-166 / Haptoinvasion assay / MMI-166 / MMP-2 / 浸潤阻害 / in vitro invasion assay / MMP inhibitor / lung cancer / tumor invasion / アンチセンス / リポソーム / オリゴヌクレオチド / 抗癌剤 / 5-FU / thymidylate synthase / antisense oligonucleotide / HVJ-リポソーム / antisense / oligodeoxynucleotide / liposome / 前癌病変 / クロム蓄積量 / 蛍光X線元素分析装置 / 遺伝子変化 / chromate lung cancer / premalignant lesions / chromate accumulation / microscopic X-ray fuorescence analyzer / genomic change / DNA修復遺伝子 / gene instability / 発癌 / 発癌過程 / DNA修復遺伝子蛋白 / hMLH / クロム酸塩蓄積量 / DNA mismatch repair gene / pre-malignant lesion / carcinogenesis / 重症筋無力症 / 胸腺腫 / 次世代シークエンサー / 胸腺上皮細胞 / 胸腺種 / 胸腺癌 / DNAメチル化 / 網羅的解析 / CpGサイト / 癌抑制遺伝子 / ＤＮＡメチル化 / ＣｐＧサイト / 肺腺癌 / がん抑制遺伝子 / epigenetic / 悪性度

研究代表者以外

T cell receptor / Vβ gene / モニタリング / ラット / クロム肺癌 / p53遺伝子 / ras遺伝子 / LOH / gene instability / enriched-PCR / microsatellite法 / サイトカイン / サイクロスポリン / 急性拒絶 / 慢性拒絶 / 免疫組織 / RT-PCR法 / ラット移植肺モデル / 気管支随伴リンパ組織(BALT) / 長期生着モデル / RT-PCR / IL-2 / IFNγ / FK506 / リンパ行性転移 / CD44 variant exon 6 / 肺癌 / 同所性移植 / SCIDマウスモデル / SCIDマウス / 非小細胞肺癌 / 術前導入療法 / 化学放射線療法 / 機能画像診断 / 機能画像 / 分子生物学的評価 / 喫煙防止教育 / 小学生 / 中学生 / 防煙教育 / 家族喫煙 / 小中学生 / 大学入学時 / 教育効果 / 高校生 / 胸膜浸潤 / 蛍光診断 / 5-ALA / 自家蛍光 / 胸腺上皮性腫瘍 / DNAメチル化 / 発癌 / 肺移植 / TCR / TCR V / 急性拒絶反応 / 慢性拒絶反応 / 免疫抑制 / TCRVbeta / TCRV-beta / lung transplantation / rat / TCR V-BETA / acute rejection / chronic rejection / immunosuppression / Microsatellite instability / loss of heterozygosity / ミスマッチ修復遺伝子 / hMLH1 hMSH2 / Chromate lung cancer / Mismatch repair gene / ラット肺移植 / ラット同所性肺移植 / 胸腺内移植 / ドナー骨髄細胞 / 拒絶反応 / クロム / ヒトクロム肺癌 / 中枢性肺偏平上皮癌 / クロム蓄積量 / 中枢性肺扁平上皮癌 / クロム肺癌 chromate Lung cancer / クロム酸塩 / Chromium / chromate lung cancer / squamous cell caarcinoma / accumulation of chromium / Rho A / Rho B / Rac-1 / estrogen receptor / DMBA induced breast cancer / breast cancer / reperfusion / ischemia-reperfusion / preservation / protein tyrosine phosphorylation / mitogen-activated protein kinase / ERK / protein tyrosine kinase / protein tyrosine phosphatase / 初代培養癌細胞 / 同所性移植モデル / 転移様式 / DNAマイクロアレイ / 遺伝子変化 / 手術検体 / 転移様 / 同所移植モデル / 肺癌初代培養 / 抗癌剤感受性試験 / lung cancer / primary cultured cancer cell / orthotopic implantation model / metastatic pattern / DNA microarray / RNA expression / operation sample / 医用画像認識 / ニューラルネットワーク / X-ray CT image / GMDH / Medical image recognition / Neural networks / 肺再生 / 肺 / 胎仔肺組織移植 / 胎児肺組織移植 / 胎仔肺 / 移植 / 肺線維症 / 胎仔肺移植 / ブレオマイシン / 再生 / 組織修復 / lung regeneration / lung / fetal lung tissue / fetal lung / transplantation / pulmonary fibrosis / bleomycine / 食道癌 / 甲状腺未分化癌 / リンパ節転移 / 転移関連遺伝子 / 抗癌剤関連遺伝子 / TaqMan Low Density Array / esophageal cancer / thyroid anaplastic carcinoma / lymph node metastasis / metastasis related gene / anti cancer agent related gene / 縮小手術 / 放射線治療 / PET/CT / FLT / FDG / 分子イメージング / FLT-PET / FDG-PET / imaging predictors / 同所移植性肺癌マウスモデル / 18F-FLT / 18F-FDG / PET / radiation therapy / 癌 / 放射線 / マウス肺移植 / ips細胞 / GFPマウス / 胎児肺 / 肺再生医療 / 肺がん患者 / がん手術療法 / Hope / がんリハビリテーション看護 / がんリハビリテーション / 術後 / 看護ケアモデル / 手術 / 同所移植 / 化学療法 / 免疫療法 / Radiomics / Radiotherapy / Prediction / MRI / Mouse model / レディオミクス / 治療効果判定 / マウスモデル / 治療効果予測 / マウスがんモデル / がん / 人工知能 / 新型たばこ / 加熱式タバコ / 電子タバコ / 加熱式たばこ / 免疫担当細胞 / 癌微小環境 / マウス肺癌細胞株 / 肺癌同種同所移植モデル / 免疫チェックポイント阻害薬 / 肺腺癌 / 浸潤診断 / ピラティス / 看護プログラム / ICT / PRO-CTCAE / 外来化学療法 / 乳癌 / リスクアセスメント

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2020年10月26日

クロム酸塩のepigeneticな異常と発癌の関連性の研究 ―クロム酸塩に暴露した労働者の肺癌材料を利用した網羅的なDNAメチル化解析―

近藤和也滝沢宏光吉田光輝森田明典丹黒章

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