研究成果

[雑誌論文] Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry and ex vivo measurements of single-unit mechanosensitive bladder afferent activities in the rat.

Ito H, Aizawa N, Sugiyama R, Watanabe S, Takahashi N, Tajimi M, Fukuhara H, Homma Y, Kubota Y, Andersson KE, Igawa Y. 2016

[雑誌論文] Effects of Sildenafil, a Phosphodiesterase Type 5 Inhibitor, on the Primary Single Afferent Activity of the Rat Bladder

Aizawa N, Ito H, Sugiyama R, Fujimura T, Fukuhara H, Kume H, Homma Y, Igawa Y. 2015

[雑誌論文] Inhibitory effects of retigabine, a Kv7 channel activator, on mechanosensitive primary bladder afferent activities and nociceptive behaviors in rats.

Aizawa N, Wakamatsu D, Kida J, Otsuki T, Saito Y, Matsuya H, Homma Y, Igawa Y. 2015

[学会発表] 膀胱求心性神経の生理学的・薬理学的機能解析

相澤直樹、井川靖彦 2015

[学会発表] ラット膀胱伸展受容一次求心性神経活動に及ぼす選択的α1Aアドレナリン受容体拮抗薬シロドシンの膀胱内投与による効果

相澤直樹、伊藤悠城、杉山梨乃、藤村哲也、福原浩、久米春喜、本間之夫、井川靖彦 2015

[学会発表] ラット膀胱伸展受容一次求心性神経のAδおよびC線維の活動性に及ぼすresiniferatoxin脱感作の直接作用

相澤直樹、伊藤悠城、杉山梨乃、亀井潤、秋山佳之、市原浩司、本間之夫、井川靖彦 2015

[雑誌論文] 下部尿路の求心性神経とNO/cGMP

相澤直樹、井川靖彦 2015

[学会発表] OABの新規治療薬の開発

相澤直樹、井川靖彦 2015

[学会発表] Direct influence of systemic desensitization by resiniferatoxin on the activities of Aδ- and C-fibers in the rat primary mechanosensitive afferents.

Aizawa N, Ito H, Sugiyama R, Kamei J, Akiyama Y, Ichihara K, Homma Y, Igawa Y 2015

[雑誌論文] URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.

Aizawa N, Gandaglia G, Hedlund P, Fujimura T, Fukuhara H, Montorsi F, Homma Y, Igawa Y. 2015

[学会発表] Inhibitory effects of intravesical administration of silodosin, a selective α1A-adrenoceptor antagonist, on single-unit primary bladder afferent activities of the rat.

Aizawa N, Ito H, Sugiyama R, Kamei J, Akiyama Y, Ichihara K, Homma Y, Igawa Y 2015

[雑誌論文] Functional roles of bladder α1-adrenoceptors in the activation of single-unit primary bladder afferent activity in rats.

Aizawa N, Sugiyama R, Ichihara K, Fujimura T, Fukuhara H, Homma Y, Igawa Y. 2015

[学会発表] 網羅的遺伝子解析を用いた、マウス膀胱における遺伝子発現の加齢性変化と性差の検討

相澤直樹、亀井潤、伊藤悠城、堀田晴美、藤田泰典、伊藤雅史、小島俊男、本間之夫、井川靖彦 2015

[学会発表] Direct evidence for contribution of muscarinic receptors to the facilitation of primary bladder mechanosensitive c-fiber afferents if the rat.

Aizawa N, Ito H, Sugiyama R, Kamei J, Akiyama Y, Fujimura T, Suzuki M, Homma Y, Igawa Y 2014

[学会発表] ラット膀胱伸展受容求心性神経活動制御における膀胱アドレナリンα1Ｄ受容体の生理的役割

相澤直樹、伊藤悠城、杉山梨乃、亀井潤、秋山佳之、市原浩司、藤村哲也、鈴木基文、福原浩、久米春喜、本間之夫、井川靖彦 2014

[学会発表] ラット膀胱伸展受容一次求心性神経のＣ線維の活動性に対する膀胱ムスカリン受容体の促進的寄与

相澤直樹、伊藤悠城、杉山梨乃、亀井潤、秋山佳之、市原浩司、藤村哲也、鈴木基文、福原浩、久米春喜、本間之夫、井川靖彦 2014

[学会発表] 新規抗コリン薬fesoterodineの活性代謝物5-hydroxymethyl tolterodineは、ラット膀胱伸展受容求心性神経において、capsaicin感受性C線維を選択的に抑制する

相澤直樹、本間之夫、井川靖彦 2014

[学会発表] URB937, a peripherally-restricted inhibitor of fatty acid amide hydrolase, reduces prostaglandlin E2-induced hyperactivity of bladder mechanoafferent nerve fibers in rats.

Aizawa N, Hedlund P, Homma Y, Igawa Y 2014

[雑誌論文] 下部尿路機能障害に対する治療候補薬としての内因性カンナビノイドの可能性

相澤直樹 2014

[学会発表] Inhibitory effect of URB937, a peripherally-restricted inhibitor of fatty acid amide hydrolase, on prostaglandin E2-induced hyperactivity of bladder mechanoafferent nerve fibers in rats.

Aizawa N, Hedlund P, Homma Y, Igawa Y 2014

[学会発表] Physiological role of the bladder Alpha1D- adrenoceptor in the activation of single-unit primary bladder afferent activity in rats.

Aizawa N, Ito H, Sugiyama R, Kamei J, Akiyama Y, Fujimura T, Suzuki M, Homma Y, Igawa Y 2014

[学会発表] Selective inhibitory effect of 5-hydroxymethyl tolterodine (5-HMT), an active metabolite of fesoterodine, on capsaicin-sensitive C-fibers among the primary bladder mechanosensitive afferent nerves in the rat.

Aizawa N, Homma Y, Igawa Y 2014