トップ›研究者を探す›がん酸性環境がもたらすがん細胞の薬剤耐性獲得機序の解明と新規治療薬の開発

がん酸性環境がもたらすがん細胞の薬剤耐性獲得機序の解明と新規治療薬の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26830108
研究種目 若手研究(B)
研究分野 生物系
総合生物
腫瘍学
腫瘍治療学
研究機関 徳島大学
代表研究者 中村 信元
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額（合計） 3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
配分額（履歴） 2015年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2014年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード がん酸性環境
pim2
酸性環境
多発性骨髄腫
cucurbitacin

研究成果

[雑誌論文] 多発性骨髄腫

安倍正博、三木浩和、中村信元 2016

[雑誌論文] Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions

Shingen NAKAMURA , Hirokazu MIKI , Asuka ODA , Ryota AMACHI , Jumpei TERAMACHI , Kimiko SOGABE , Hikaru FUJINO , Tomoko MARUHASHI , Shiro FUJII , Kumiko KAGAWA and Masahiro ABE 2016

[雑誌論文] Lipopolysaccharide-Induced CXCL10 mRNA Level and Six Stimulant-mRNA Combinations in Whole Blood: Novel Biomarkers for Bortezomib Responses Obtained from a Prospective Multicenter Trial for Patients with Multiple Myeloma.

Watanabe T, Mitsuhashi M, Sagawa M, Ri M, Suzuki K, Abe M, Ohmachi K, Nakagawa Y, Nakamura S, Chosa M, Iida S, Kizaki M. 2015

[学会発表] Cytotoxic efficacy of Pim inhibitors and anti-myeloma agents in combination

Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe 2015

[学会発表] Alteration of Pim-2 expression by clinically available anti-myeloma agents: combinatory anti-myeloma effects with Pim inhibition

Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe 2015

[雑誌論文] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.

Hiasa M, Teramachi J, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M 2015

[学会発表] Cytotoxic efficacy of Pim inhibitors and anti-myeloma agents in combination

Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe 2015

[雑誌論文] Induction of endoplasmic reticulum stress by bortezomib sensitizes myeloma cells to DR5-mediated cell death

Miki H, Nakamura S, Oda A, Amachi R, Watanabe K, Hanson D, Teramachi J, Hiasa M, Yagi H, Sogabe K, Takahashi M, Maruhashi T, Udaka K, Harada T, Fujii S, Nakano A, Kagawa K, Ri M, Iida S, Ozaki S, Matsumoto T, Abe M. 2015

[学会発表] Combinatory effects of Pim inhibitor with clinically available anti-myeloma agents

Shingen Nakamura, Hirokazu Miki, Hirofumi Tenshin, Ryota Amachi, Derek Hanson, Keiichiro Watanabe, Jumpei Teramachi, Asuka Oda, Kimiko Sogabe, Hikaru Fujino, Tomoko Maruhashi, Shiro Fujii　,Kumiko Kagawa, Masahiro Abe 2015

[雑誌論文] Human immunodeficiency virus-positive secondary syphilis mimicking cutaneous T-cell lymphoma

Yamashita M, Fujii Y, Ozaki K, Urano Y, Iwasa M, Nakamura S, Fujii S, Abe M, Sato Y, Yoshino T 2015

[雑誌論文] Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.

Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A1, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M. 2015