がんに対する抗体療法と細胞療法とのクロストーク治療法の開発

トップ›研究者を探す›がんに対する抗体療法と細胞療法とのクロストーク治療法の開発

代表研究者	安川正貴
研究課題番号	KAKENHI-PROJECT-26670467
研究種目	挑戦的萌芽研究
研究分野	生物系医歯薬学内科系臨床医学血液内科学
研究機関	愛媛大学
研究期間開始年月日	2014/4/1
研究期間終了年度	2015
研究ステータス	完了 (2015/4/1)
配分額（合計）	3,640,000 (直接経費 :2,800,000、間接経費 :840,000)
配分額（履歴）	2015年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000) 2014年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード	がん免疫療法細胞傷害性T細胞 ADCC活性キメラ遺伝子 CD16 CAR-T TCR-T 遺伝子治療 chimeri antigen receptor 悪性リンパ腫細胞障害性T細胞抗体療法 ADCC

研究成果

[雑誌論文] Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.

Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, and Yasukawa M. 2015

[学会発表] Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Hiroaki Ikeda, Yasushi Akahori, Motohiro Yoneyama, Yuki Orito, Yoshihiro Miyahara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Kazutoh Takesako, Hiroshi Fujiwara, Masaki Yasukawa, Hiroshi Shiku 2015

[学会発表] Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia

Isao Tawara, Masahiro Masuya, Shinichi Kageyama, Tetsuya Nishida, Seitaro Terakura, Makoto Murata, Hiroshi Fujiwara, Yoshiki Akatsuka, Hiroaki Ikeda, Yoshihiro Miyahara, Daisuke Tomura, Ikuei Nukaya, Kazutoh Takesako, Nobuhiko Emi, Masaki Yasukawa, Naoyuki Katayama, Hiroshi Shiku 2015

[学会発表] Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Nicholas Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa 2015

[雑誌論文] Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer

Rowan AG, Suemori K, Fujiwara H, Yasukawa M, Tanaka Y, Taylor GP, Bangham C. 2014

[学会発表] Activation Status of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Jun Yamanouchi , Takaaki Hato, Etsuko Matsubara, Taichi Azuma, Hideyuki Nakanishi, Hiroshi Fujiwara, Yoshihiro Yakushijin, and Masaki Yasukawa 2014

[学会発表] Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto , Hiroshi Fujiwara, Hiroki Tanaka, Fumihiro Ochi , Hiroaki Asai, Sachiko Okamoto, JunichiMineno , Kiyotaka Kuzushima, Hiroshi Shiku, John Barrett, and Masaki Yasukawa 2014