トップ研究者を探す肺・肝臓癌に対する機能的画像を用いたオーダーメイド放射線治療法の開発

肺・肝臓癌に対する機能的画像を用いたオーダーメイド放射線治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26461889
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
放射線科学
研究機関 広島大学
代表研究者 木村 智樹
研究分担者 永田 靖
研究分担者 村上 祐司
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 4,550,000 (直接経費 :3,500,000、間接経費 :1,050,000)
配分額(履歴) 2016年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2015年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2014年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード 肺癌
肝臓癌
肺機能画像
肝機能画像
放射線治療
放射線肺臓炎
オーダーメイド治療

研究成果

[雑誌論文] Functional Image-guided Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients

Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata. 2017

[雑誌論文] Functional Image-Guided Radiotherapy Planning in Volumetric Modulated Arc Therapy for Patients with Malignant Pleural Mesothelioma

Yoshiko Doi, Tomoki Kimura, Takeo Nakashima, Keiichi Onishi, Yuki takeuchi, Ikuno Nishibuchi, Tomoyuki Okabe, Yuji Murakami, Yasushi Nagata 2017

[学会発表] Combined ventilation and perfusion imaging correlates with the dosimetric parameters of radiation pneumonitis in radiation therapy planning for lung cancer

Tomoki Kimura, Takeo Nakashima, Akito Saito, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Teiji Nishio, Yasushi Nagata 2016

[学会発表] 肺機能画像は放射線肺臓炎の線量分布パラメータに相関する

木村智樹、中島健雄、斉藤明登、竹内有樹、高橋一平、西淵いくの、村上祐司、西尾禎治、永田 靖 2016

[学会発表] Functional lung imaging correlates with DVH parameters of radiation pneumonitis

Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Akito Saito, Yasushi Nagata 2016

[雑誌論文] Clinical utility of gadoxetate disodium-enhanced hepatic MRI for stereotactic body radiotherapy of hepatocellular carcinoma.

Yuko Nakamura, Tomoki Kimura, Toru Higaki, Yukiko Honda, Daisuke Komoto, Takuji Yamagami, Makoto Iida, Yasushi Nagata, Yohji Honda, Hiroshi Aikata, Kazuaki Chayama, Kazuo Awai. 2015

[学会発表] Preliminary results of postoperative radioactive iodine ablation therapy for differentiated thyroid cancer.

Masahiro Kenjo, Hideo Kawabata, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Yuji Murakami, Tomoki Kimura, Yasushi Nagata. 2015

[雑誌論文] Combined ventilation and perfusion imaging correlate with the dosimetric parameters of radiation pneumonitis in radiotherapy planning for lung cancer.

Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Hideo Kawabata, Ikuno Nishibuchi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata. 2015

[雑誌論文] The time course of dynamic computed tomographic appearance of radiation injury to the cirrhotic liver following stereotactic body radiation therapy for hepatocellular carcinoma.

Tomoki Kimura, Shigeo Takahashi, Ippei Takahashi, Ikuno Nishibuchi, Yoshiko Doi, Masahiro Kenjo, Yuji Murakami, Yohji Honda, Hiroshi Aikata, Kazuaki Chayama, and Yasushi Nagata. 2015

[学会発表] Computed Tomographic Appearance of Radiation Injuries in Lung After Two Prescribed Dose of 48Gy With Stereotactic Body Radiation Therapy.

Katsumaro Kubo, Tomoki Kimura, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa Yuji Murakami, Yasushi Nagata. 2015

[学会発表] A phase I study of stereotactic body radiation therapy for centrally located stage IA non-small cell lung cancer: Japan Radiation Oncology Study Group (JROSG10-1)

Tomoki Kimura, Yasushi Nagata, Hideyuki Harada, Shinya Hayash, Yukinori Matsuo, Nami Ueki, Tsuyoshi Takanaka, Masaki Kokubo, Kenji Takayama, Hiroshi Onishi, Koichi Hirakawa, Yoshiyuki Shioyama, Takeshi Ehara. 2015

[雑誌論文] Clinical experience of volumetric modulated arc therapy for malignant pleural mesothelioma after extrapleural pneumonectomy

Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Tsuyoshi Katsuta, Shigeo Takahashi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata. 2015

[学会発表] Preliminary outcomes of induction chemotherapy + VMAT with concurrent chemotherapy for stage IVA/IVB oro- and hypopharyngeal cancer.

Yuji Murakami, Tomoki Kimura, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yasushi Nagata. 2015

[学会発表] Interstitial Brachytherapy for Early-Stage Tongue Cancer: Analysis of the Long-term Treatment Results for Survival and Complications.

Yuki Takeuchi, Yuji Murakami, Katsumaro Kubo, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata, Minoru Fujita, Masaru Konishi. 2015

[図書] Stereotactic Body Radiation Therapy, Principles and Practices.

Yasushi Nagata, Tomoki Kimura, et al. 2015

[学会発表] Treatment outcomes of preoperative chemoradiotherapy for Japanese patients with locally advanced rectal cancer.

Hideo Kawabata, Yuji Murakami, Hiromi Sakaguchi, Katsumaro Kubo, Nobuki Imano, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata. 2015

[雑誌論文] Stereotactic body radiotherapy for patients with small hepatocellular carcinoma ineligible for resection or ablation therapies

Tomoki Kimura, Hiroshi Aikata, Shigeo Takahashi, Ippei Takahashi, Ikuno Nishibuchi,  Yoshiko Doi, Masahiro Kenjo, Yuji Murakami, Yoji Honda, Hideaki Kakizawa, Kazuo Awai, Kazuaki Chayama, Yasushi Nagata. 2015

[雑誌論文] The role of 3D-conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma.

Hatsue Fujino, Tomoki Kimura, Hiroshi Aikata, et al. 2015

[学会発表] Involved-field radiation therapy for patients with stage III non-small-cell lung cancer.

Katsumaro Kubo, Tomoki Kimura, Hiromi Sakaguchi, Nobuki Imano, Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuji Murakami, Yasushi Nagata. 2015

[学会発表] Incidence and Clinical Features of Metachronous Esophageal Cancer After Definitive Radiation Therapy for Esophageal Cancer.

Yuji Murakami, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yasushi Nagata. 2015

[雑誌論文] Results of sequential chemoradiotherapy for intracranial germinoma

Masahiro Kenjo, Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Yuji Murakami, Tomoki Kimura, Yoshiko Doi, Tomoyuki Okabe, Kazuhiko Sugiyama, Yasushi Nagata. 2015

[学会発表] A Quantitative Index for Phase Selection in Planning of Respiratory Gating Radiation Therapy for Lung Cancer.

Nobuki Imano, Tomoki Kimura, Ikuno Nishibuchi, Takeo Nakashima, Katsumaro Kubo, Hiromi Sakaguchi, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Yasushi Nagata. 2015

[学会発表] Gd-EOB-DTPA Enhanced MRI Guided Stereotactic Body Radiation Therapy Planning for Patients With Hepatocellular Carcinoma.

Uranchimeg Tsegmed, Tomoki Kimura, Takeo Nakashima, Yuko Nakamura, Toru Higaki, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami, Kazuo Awai, Yasushi Nagata. 2015

[学会発表] Clinical outcomes of stereotactic body radiotherapy for small lung tumors clinically diagnoses as primary lung cancer.

Hiromi Sakaguchi, Tomoki Kimura, Katsumaro Kubo, Nobuki Imano, Hideo Kawabata, Yuki Takeuchi, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuji Murakami, Yasushi Nagata. 2015

[雑誌論文] Pilot Study of Stereotactic Body Radiation Therapy Combined with Transcatheter Arterial Chemoembolization for Small Hepatocellular Carcinoma.

Yohji Honda, Tomoki Kimura, Hiroshi Aikata, Takashi Nakahara, Noriaki Naeshiro, 2014

[雑誌論文] Case Reports of Portal Vein Thrombosis and Bile Duct Stenosis after Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma.

Shigeo Takahashi, Tomoki Kimura, Masahiro Kenjo, Ikuno Nishibuchi, Ippei Takahashi, Yuki Takeuchi, Yoshiko Doi, Yuko Kaneyasu, Yuji Murakami, Yoji Honda, Hiroshi Aikata, Kazuaki Chayama, and Yasushi Nagata 2014

[雑誌論文] Time-Adjusted Internal Target Volume: A Novel Approach Focusing on Heterogeneity of Tumor Motion Based on Four-Dimensional Computed Tomography Imaging for Radiotherapy Planning of Lung Cancer.

Ikuno Nishibuchi, Tomoki Kimura, Takeo Nakashima, Yusuke Ochi, Ippei Takahashi, Yoshiko Doi, Masahiro Kenjo, Yuko Kaneyasu, Yuji Murakami, Koichi Wadasaki, Yasushi Nagata. 2014

[学会発表] Functional Image-Guided Stereotactic Body Radiation Therapy Planning Using the Intensity Modulated Radiation Therapy Technique for Patients With Hepatocellular Carcinoma.

Tsegmed U, Tomoki Kimura, Takeshi Nakashima, Yuko Nakamura, Toru Higaki, Tsuyoshi Katsuta, Nobuki Imano, Yoshiko Doi, Masahiro Kenjo, Yuko Kaneyasu, Shuichi Ozawa, Yuji Mukrakami, Kazuo Awai, Yasushi Nagata. 0

[学会発表] A Prospective Study of Functional Image Guided Radiation Therapy Planning in Lung Cancer Patients.

Tomoki Kimura, Takeshi Nakashima, Yoshiko Doi, Nobuki Imano, Tsuyoshi Katsuta, Tomoyuki Okabe, Masahiro Kenjo, Shuichi Ozawa, Yuji Mukrakami, Yasushi Nagata 0

[学会発表] Current status of stereotactic body radiotherapy for hepatocellular carcinoma in Japan

Tomoki Kimura 0

[学会発表] Four-Dimensional Assessment of the Internal Motion of Esophagus in Early-Stage Esophageal Cancer Patients Using Metal Markers.

Yoshiko Doi, Yuji Mukrakami, Tsuyoshi Katsuta, Nobuki Imano, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata. 0

[学会発表] Long-Term Results of Postoperative 3-Dimensional High-Dose-Rate Brachytherapy for Soft-Tissue Sarcomas

Masahiro Kenjo, Kubo T, Shimose S, Fujimori J, Nakashima Y, Yoshiko Doi, Tomoyuki Okabe, Yuji Mukrakami, Tomoki Kimura, Yuko Kaneyasu, Yasushi Nagata. 0

[学会発表] Results of Neoadjuvant Chemoradiation Therapy Followed by Surgery for Locally Advanced Esophageal Squamous Cell Carcinoma.

Yuji Mukrakami, Nobuki Imano, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Yuko Kaneyasu, Tomoki Kimura, Jun Hihara, Yasushi Nagata 0