トップ›研究者を探す›疾患モデルマウスを用いた自己免疫疾患の病態解明

疾患モデルマウスを用いた自己免疫疾患の病態解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26461464
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
膠原病・アレルギー内科学
研究機関 徳島大学
代表研究者 西嶋 仁
研究分担者 松本 満
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額（合計） 4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
配分額（履歴） 2016年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2015年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2014年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード 免疫学
Aire
自己免疫疾患
mTEC
AIRE
遺伝子改変マウス
負の選択

研究成果

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice

Hitoshi Nishijima, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto 2017

[学会発表] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE

Hitoshi Nishijima, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto 2017

[学会発表] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function

Jyunko Morimoto, Yumiko Nishikawa, Hitoshi Nishijima, Mitsuru Matsumoto 2017

[学会発表] ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析

Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto 2017

[学会発表] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity

Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto 2016

[学会発表] Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity

Hitoshi Nishijima, Mitsuru Matsumoto 2016

[学会発表] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells

Hitoshi Nishijima, Mitsuru Matsumoto 2016

[学会発表] Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program.

Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka 2015

[学会発表] Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE.

Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano, and Mitsuru Matsumoto 2015

[学会発表] Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program.

Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto 2015

[学会発表] A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein.

Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima, and Mitsuru Matsumoto 2015

[学会発表] Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells

Kawano, H., Morimoto, J., Mouri, Y., Nishijima, H., Nishioka, Y., Matsumoto, M. 0

[学会発表] Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex

Nishijima, H., Morimoto, J., Mouri, Y., Kawano, H., Ikuta, K., Matsumoto, M. 0

[学会発表] 胸腺皮質上皮細胞への異所性発現による Aire の機能解析

西嶋　仁、生田宏一、松本　満 0

[学会発表] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment

Nishijima, H., Morimoto, J., Kawano, H., Mouri, Y., Ikuta, K., Matsumoto, M. 0

[学会発表] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor

Matsumoto, M., Nishijima, H. 0