白血病p53による白血病微小環境の変調

トップ›研究者を探す›白血病p53による白血病微小環境の変調

代表研究者	小島研介
研究課題番号	KAKENHI-PROJECT-26461425
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学血液内科学
研究機関	佐賀大学
研究期間開始年月日	2014/4/1
研究期間終了年度	2016
研究ステータス	完了 (2016/4/1)
配分額（合計）	4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額（履歴）	2016年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000) 2015年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2014年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
キーワード	白血病 p53 微小環境幹細胞 MDM2 造血微小環境

研究成果

[雑誌論文] FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B cell acute leukemia.

Ishizawa J, Sugihara E, Kuninaka S, Mogushi K, Kojima K, Benton CB, Zhao R, Chachad D, Hashimoto N, Jacamo RO, Qiu Y, Yoo SY, Okamoto S, Andreeff M, Kornblau SM, Saya H. 2017

[雑誌論文] The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

Nishida Y, Maeda A, Kim MJ, Cao L, Kubota Y, Ishizawa J, AlRawi A, Kato Y, Iwama A, Fujisawa M, Matsue K, Weetall M, Dumble M, Andreeff M, Davis TW, Branstrom A, Kimura S, Kojima K. 2017

[雑誌論文] The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma.

Kojima K, Maeda A, Yoshimura M, Nishida Y, Kimura S. 2016

[学会発表] The PPM1D inhibitor GSK2830371 has p53-dependent anti-lymphoma effects and enhances bortezomib-induced apoptosis in mantle cell lymphoma

Kensuke Kojima, Mariko Yoshimura, Aya Maeda, Hiroaki Kitamura, Yuki Nishida, Shinya Kimura 2016

[雑誌論文] Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia.

Andreeff M, Kelly KR, Yee K, Assouline S, Strair R, Popplewell L, Bowen D, Martinelli G, Drummond MW, Vyas P, Kirschbaum M, Iyer SP, Ruvolo V, González GM, Huang X, Chen G, Graves B, Blotner S, Bridge P, Jukofsky L, Middleton S, Reckner M, Rueger R, Zhi J, Nichols G, Kojima K. 2016

[雑誌論文] Pharmacological activation of wild-type p53 in the therapy of leukemia.

Kojima K, Ishizawa J, Andreeff M. 2016

[学会発表] BMI-1 inhibition by PTC-209 induces mitochondrial apoptosis in acute myeloid leukemia cells

Kensuke Kojima, Yuki Nishida, Aya Maeda, Dhruv Chachad, Hiroaki Kitamura, Jo Ishizawa, Michael Andreeff, Shinya Kimura 2015

[学会発表] Preclinical activity of the novel BMI-1 inhibitor PTC-209 in acute myeloid leukemia

Yuki Nishida, Aya Maeda, Shinya Kimura, Thomas W. Davis, Kensuke Kojima 2015

[学会発表] Targeting BMI-1 by the novel BMI-1 inhibitor PTC596 in acute leukemia

Yuki Nishida, Aya Maeda, Liangxian Cao, Melissa Dumble, Shinya Kimura Thomas W. Davis and Kensuke Kojima 2015

[雑誌論文] Reactivation of resolved infection with the hepatitis B virus immune escape mutant G145R during dasatinib treatment for chronic myeloid leukemia.

Ando T, Kojima K, Isoda H, Eguchi Y, Honda T, Ishigami M, Kimura S. 2015

[雑誌論文] Mitochondrial profiling of acute myeloid leukemia in the assessment of response to apoptosis modulating drugs.

Ishizawa J, Kojima K, McQueen T, Ruvolo V, Chachad D, Nogueras-Gonzalez GM, Huang X, Pierceall WE, Dettman EJ, Cardone MH, Shacham S, Konopleva M, Andreeff M. 2015

[図書] Targeted Therapy of Acute Myeloid Leukemia.

Kojima K, Vassilev LT. 2015

[雑誌論文] Preclinical activity of the novel BMI-1 inhibitor PTC-209 in acute myeloid leukemia: implications for leukemia therapy.

Nishida Y, Maeda A, Chachad D, Ishizawa J, Yi Hua Q, Kornblau SM, Kimura S, Andreeff M, Kojima K. 2015

[学会発表] マントル細胞リンパ腫におけるPPM1D阻害剤によるp53依存性のアポトーシス誘導効果

吉村麻里子、木村晋也、小島研介 2015

[図書] Targeted Therapy in Translational Cancer Research.

Kojima K, Andreeff M. 2015

[雑誌論文] MDM2 Inhibitor, Nutlin 3a, induces p53 dependent autophagy in acute leukemia by AMP kinase activation.

Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks J, Jacamo R, Kojima K, Ruvolo P, Fueyo-Margareto J, Konopleva M, Andreeff M. MDM2 Inhibitor, Nutlin 3a, induces p53 dependent autophagy in acute leukemia by AMP kinase activation. 2015

[雑誌論文] Diffuse bone marrow uptake of fluorodeoxyglucose in a patient with aleukaemic acute lymphoblastic leukaemia.

Kitamura H, Ando T, Kojima K, Komiya K, Sueoka-Aragane N, Kimura S. 2014

[雑誌論文] Small lymphocytic lymphoma presenting as bulky renal incidentaloma.

Kamachi K, Kojima K, Nishijima A, Takeshita M, Ando T, Kimura S. 2014

[学会発表] Induction of p53-mediated transcription and apoptosis by XPO1 inhibition in mantle cell lymphoma

Kensuke Kojima 0

[学会発表] マントル細胞リンパ腫における、XPO1阻害によるp53依存性転写の誘導と細胞死

小島研介 0

[学会発表] p53と白血病

小島研介 0

[学会発表] Prognostic impact and targeting of BMI-1 in acute myeloid leukemia

Yuki Nishida, Kensuke Kojima, Aya Maeda, Dhruv Chachad, Hiroaki Kitamura, Jo Ishizawa, Michael Andreeff, Steven Kornblau, Shinya Kimura 0