トップ研究者を探す骨髄腫骨髄微小環境がもたらす骨髄腫増殖制御機構の解明と新規治療法の開発

骨髄腫骨髄微小環境がもたらす骨髄腫増殖制御機構の解明と新規治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26461422
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
血液内科学
研究機関 徳島大学
代表研究者 安倍 正博
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2016年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2015年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2014年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード 骨髄腫
骨破壊病変
酸環境
骨形成
骨病変
TRPV1
Pim-2
TAK-1
酸性環境
骨髄微小環境

研究成果

[雑誌論文] Expansion of Th1-like Vγ9Vδ2T cells by new generation IMiDs, lenalidomide and pomalidomide, in combination with zoledronic acid.

2. Harada T, Miki H, Cui Q, Oda A, Amachi R, Teramachi J, Bat-Erdene A, Sogabe K, Iwasa M, Fujii S, Nakamura S, Kagawa K, Yoshida S, Endo I, Aihara K, Ozaki S, Matsumoto T, Abe M. 2017

[学会発表] 多発性骨髄腫:QoLの改善に向けた治療の進歩

安倍正博 2016

[雑誌論文] Susceptibility to bendamustine considerably varies among myeloma cells, but is enhanced in acidic conditions

Nakamura S , Miki H, Oda A, Amachi R, Teramachi J, Sogabe K, Fujino H, Maruhashi T, Fujii S, Kagawa K , Abe M. 2016

[学会発表] Up-regulation of the pH sensor TRPV1 in myeloma cells and their adaption to an acidic microenvironment

Ryota Amachi, Masahiro Hiasa, Jumpei Teramachi, Asuka Oda, Keiichiro Watanabe, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe 2015

[雑誌論文] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma

Hiasa M, Jumpei T, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M 2015

[雑誌論文] Induction of endoplasmic reticulum stress by bortezomib sensitizes myeloma cells to DR5-mediated cell death

Miki H, Nakamura S, Oda A, Amachi R, Watanabe K, Hanson D, Teramachi J, Hiasa M, Yagi H, Sogabe K, Takahashi M, Maruhashi T, Udaka K, Harada T, Fujii S, Nakano A, Kagawa K, Ri M, Iida S, Ozaki S, Matsumoto T, Abe M 2015

[学会発表] Pivotal role of TAK-1 in tumor growth and bone destruction in myeloma: therapeutic impact of TAK-1 inhibition

Jumpei Teramachi, Masahiro Hiasa, Asuka Oda, Hirofumi Tenshin, Ryota Amachi, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto and Masahiro Abe 2015

[雑誌論文] Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

6. Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M. 2015

[学会発表] 骨微小環境と骨髄腫の進展

安倍正博 2014

[雑誌論文] Risk factors for early-onset peripheral neuropathy caused by vincristine in patients with a first administration of R-CHOP or R-CHOP-like chemotherapy

Okada N, Hanafusa T, Sakurada T, Kawazoe K, Teraoka K, Kujime T, Abe M, Shinohara Y, Minakuchi K 2014

[学会発表] 骨髄腫骨病変の管理:ゾレドロン酸かデノスマブか

安倍正博 2014