トップ研究者を探す門脈圧亢進症による膵血流動態異常が膵内分泌障害および膵外分泌障害に及ぼす影響

門脈圧亢進症による膵血流動態異常が膵内分泌障害および膵外分泌障害に及ぼす影響

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26461034
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 愛媛大学
代表研究者 熊木 天児
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2016年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2015年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2014年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード 肝硬変
門脈圧亢進症
膵血流
膵内分泌異常
膵外分泌異常

研究成果

[雑誌論文] Comparison between real-time tissue elastography and vibration-controlled transient elastography for the assessment of liver fibrosis and disease progression in patients with primary biliary cholangitis.

Koizumi Y, Hirooka M, Abe M, Tokumoto Y, Yoshida O, Watanabe T, Nakamura Y, Imai Y, Yukimoto A, Kumagi T, Takeshita E, Ikeda Y, Hiasa Y. 2017

[雑誌論文] Efficacy of chemotherapy in elderly patients with unresectable pancreatic cancer: a multicenter review of 895 patients

Kuroda T, Kumagi T, Yokota T, Azemoto N, Hasebe A, Seike H, Nishiyama M, Inada N, Shibata N, Miyata H, Kawamura T, Imai Y, Ueno-Toshimori A, Tanaka Y, Terao T, Imamura Y, Koizumi M, Yamanishi H, Ohno Y, Hiasa Y, on behalf of the Ehime Pancreato-Cholangiology (EPOCH) Study Group 2017

[雑誌論文] Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels.

Miyake T, Hirooka M, Yoshida O, Furukawa S, Kumagi T, Koizumi M, Yamamoto S, Kuroda T, Arimitsu E, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y: 2017

[雑誌論文] Difficulty in management of intraductal papillary mucinous neoplasm-associated pancreatobiliary fistulas and the role of "pig-nose" appearance and intraductal ultrasonography in diagnosis.

Koizumi M, Kumagi T, Kuroda T, Azemoto N, Yamanishi H, Ohno Y, Yokota T, Ochi H, Tange K, Ikeda Y, Hiasa Y. 2016

[雑誌論文] Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.

Trivedi PJ, Lammers WJ, van Buuren HR, Pares A, Floreani A, Janssen HL, Invernizzi P, Battezzati PM, Ponsioen CY, Corpechot C, Poupon R, Mayo MJ, Burroughs AK, Nevens F, Mason AL, Kowdley KV, Lleo A, Caballeria L, Lindor KD, Kumagi T, et al. 2016

[雑誌論文] Early pancreatic volume reduction on CT predicts relapse in patients with type 1 autoimmune pancreatitis treated with steroids.

Ohno Y, Kumagi T, Yokota T, Azemoto N, Tanaka Y, Tange K, Inada N, Miyata H, Imamura Y, Koizumi M, Kuroda T, Hiasa Y; EPOCH Study Group. 2016

[雑誌論文] Synergistic association of changes in serum uric acid and triglycerides with changes in insulin resistance after walking exercise in community-dwelling older women.

Kawamoto R, Katoh T, Ninomiya D, Kumagi T, Abe M, Kohara K. 2016

[雑誌論文] Low alcohol consumption increases the risk of impaired glucose tolerance in patients with non-alcoholic fatty liver disease.

Miyake T, Kumagi T, Hirooka M, Furukawa S, Yoshida O, Koizumi M, Yamamoto S, Watanabe T, Yamamoto Y, Tokumoto Y, Takeshita E, Abe M, Kitai K, Matsuura B, Hiasa Y. 2016

[雑誌論文] Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.

Lammers WJ, Hirschfield GM, Corpechot C, Nevens F, Lindor KD, Janssen HL, Floreani A, Ponsioen CY, Mayo MJ, Invernizzi P, Battezzati PM, Parés A, Burroughs AK, Mason AL, Kowdley KV, Kumagi T, Harms MH, Trivedi PJ, Poupon R, Cheung A, Lleo A, Caballeria L, Hansen BE, van Buuren HR; Global PBC Study Group. 2015

[雑誌論文] A case of hepatocellular carcinoma treated by radiofrequency ablation confirming the adjacent major bile duct under hybrid contrast mode through a biliary drainage catheter.

Imai Y, Hirooka M, Ochi H, Koizumi Y, Ohno Y, Watanabe T, Tokumoto Y, Kumagi T, Abe M, Hiasa Y. 2015

[雑誌論文] An unusual case of abdominal pain.

Koizumi M, Kumagi T, Hiasa Y. 2015

[雑誌論文] Changes in oxidized low-density lipoprotein cholesterol are associated with changes in handgrip strength in Japanese community-dwelling persons.

Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T. 2015

[雑誌論文] Drug-induced Liver Injury with Serious Multiform Exudative Erythema following the Use of an Over-the-counter Medication Containing Ibuprofen

Watanabe T, Abe M, Tada F, Aritomo K, Ochi H, Koizumi Y, Tokumoto Y, Hirooka M, Kumagi T, Ikeda Y, Matsuura B, Hiasa Y. 2015

[雑誌論文] Characteristics of Japanese medical students associated with their intention for rural practice.

Kawamoto R, Uemoto A, Ninomiya D, Hasegawa Y, Ohtsuka N, Kusunoki T, Kumagi T, Abe M. 2015

[雑誌論文] Utility of contrast-enhanced transabdominal ultrasonography to diagnose early chronic pancreatitis.

Azemoto N, Kumagi T, Yokota T, Hirooka M, Kuroda T, Koizumi M, Ohno Y, Yamanishi H, Abe M, Hiasa Y, Onji M. 2015

[雑誌論文] Quantification of pancreas stiffness on intraoperative ultrasound elastography and evaluation of its relationship with postoperative pancreatic fistula.

Hatano M, Watanabe J, Kushihata F, Tohyama T, Kuroda T, Koizumi M, Kumagi T, Hisano Y, Sugita A, Takada Y. 2015

[雑誌論文] Brachial-ankle pulse wave velocity is a predictor of walking distance in community-dwelling adults.

Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T. 2015

[雑誌論文] Mildly Elevated Serum Bilirubin Levels Are Negatively Associated with Carotid Atherosclerosis among Elderly Persons.

Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T, Abe M. 2014

[雑誌論文] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.

Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y. 2014

[雑誌論文] Levels of alkaline phosphatase and bilirubin values are surrogate endpoints of outcome for patients with primary biliary cirrhosis; an international follow-up study.

Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HLA, Invernizzi P, Mason AL, Talwalkar J, Ponsioen CY, Floreani A, Corpechot C, Mayo MJ, Battezzati PM, Parés A, Nevens F, Burroughs AK, Kowdley KV, Trivedi PJ, Kumagi T, et al. ; on behalf of the Global PBC Study Group. 2014

[雑誌論文] Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation.

Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H, Hiasa Y. 2014

[雑誌論文] Effect of weight loss on central systolic blood pressure in elderly community-dwelling persons.

Kawamoto R, Kohara K, Katoh T, Kusunoki T, Ohtsuka N, Abe M, Kumagi T, Miki T. 2014

[雑誌論文] Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Elderly Persons.

Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T. 2014

[雑誌論文] Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

Trivedi P, Bruns T, Cheung AC, Li KK, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Neuberger J, Janssen H, Hirschfield GM. 2014

[雑誌論文] Good maternal and fetal outcomes in pregnancy associated with primary biliary cirrhosis.

Trivedi P, Kumagi T, Al-Harthy N, Coltescu C, Ward S, Cheung AC, Hirschfield GM. 2014

[雑誌論文] Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus.

Furukawa S, Yamamoto S, Maruyama K, Miyake T, Ueda T, Niiya T, Takatoshi S, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Matsuura B, Hiasa Y, Onji M, Tanigawa T. 2014

[雑誌論文] An HBV-HIV co-infected patient treated with tenofovir-based therapy who achieved HBs antigen/antibody seroconversion.

Watanabe T, Tokumoto Y, Hirooka M, Koizumi Y, Tada F, Ochi H, Abe M, Kumagi T, Ikeda Y, Matsuura B, Takada K, Hiasa Y. 2014

[雑誌論文] Signet-ring cell carcinoma of the gallbladder complicated with pulmonary tumor thrombotic microangiopathy.

Ohno Y, Kumagi T, Kuroda T, Koizumi M, Azemoto N, Yamanishi H, Oda M, Hirooka M, Abe M, Ikeda Y, Matsuura B, Onji M, Soga Y, Mizuno Y, Sugita A, Hiasa Y. 2014