トップ研究者を探す細胞内亜鉛イオンによる化学物質の細胞毒性の増強・抑制メカニズム解析

細胞内亜鉛イオンによる化学物質の細胞毒性の増強・抑制メカニズム解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26340039
研究種目 基盤研究(C)
研究分野 総合系
環境学
環境解析学
放射線・化学物質影響科学
研究機関 徳島大学
代表研究者 小山 保夫
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額(合計) 3,640,000 (直接経費 :2,800,000、間接経費 :840,000)
配分額(履歴) 2017年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2016年度:780,000 (直接経費 :600,000、間接経費 :180,000)
2015年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2014年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
キーワード 亜鉛イオン
細胞毒性
亜鉛
防汚剤
カルシウム
抗菌剤
環境影響評価

研究成果

[雑誌論文] Modification of cell vulnerability to oxidative stress by N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, in rat thymocytes

Yumiko Nishimura-Danjobara, Keisuke Oyama, Tomohiro Oyama, Kumio Yokoigawa, Yasuo Oyama 2019

[雑誌論文] Membrane hyperpolarization and depolarization of rat thymocytes by azoxystrobin, a post harvest fungicide

Naohiro Imura, Masamichi Ae, Rin Hoshino, Masami Abe, Tatsuya Yamamuro, Keisuke Oyama, Yasuo Oyama 2019

[雑誌論文] N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+

Yumiko Nishimura-Danjobara, Keisuke Oyama, Kaori Kanemaru, Keiko Takahashi, Kumio Yokoigawa and Yasuo Oyama 2018

[雑誌論文] Hyperpolarization by N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes

Yumiko Nishimura-Danjobara, Keisuke Oyama, Kumio Yokoigawa and Yasuo Oyama 2018

[雑誌論文] Ziram, a dithiocarbamate fungicide, exhibits pseudo-cytoprotective actions against oxidative stress in rat thymocytes: Possible environmental risks.

Kanemoto-Kataoka Y, Oyama K, Oyama TM, Ishibashi H, Oyama Y 2018

[雑誌論文] Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn2+

Mizuki Ikeda, Junji Deguchi, Shota Fukushima, Ai Qingyu, Norihiro Katayama, Hajime Miura and Yasuo Oyama 2018

[雑誌論文] Zinc-dependent and independent actions of hydroxyhydroquinone on rat thymic lymphocytes

Honoka Wada, Keisuke Oyama, Risa Kamae, Toshiya Masuda, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama 2018

[雑誌論文] Captan-induced increase in the concentrations of intracellular Ca2+ and Zn2+ and its correlation with oxidative stress in rat thymic lymphocytes

Tomomi Inoue, Maika Kinoshita, Keisuke Oyama, Norio Kamemura, Yasuo Oyama 2018

[雑誌論文] Cellular adverse actions of dibromoacetonitrile, a water bacterial control, at sublethal levels in rat thymocytes

Takumi Kishida, Kenji Akiyoshi, Erdenedalai Erdenebat, Enhetomuru Anu, Shoji Imai, Yasuo Oyama 2018

[雑誌論文] Cytometrical analysis of the adverse effects of indican, indoxyl, indigo, and indirubin on rat thymic lymphocytes

Yurie Funakoshi, Ayako Azuma, Mizuki Ishikawa, Satoru Itsuki, Yasuaki Tamura, Kaori Kanemaru, Shogo Hirai and Yasuo Oyama 2018

[雑誌論文] Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn2+

Mizuki Ikeda, Junji Deguchi, Shota Fukushima, Ai Qingyu, Norihiro Katayama, Hajime Miura, Yasuo Oyama 2018

[雑誌論文] Zinc-related actions of sublethal levels of benzalkonium chloride: Potentiation of benzalkonium cytotoxicity by zinc

Tsuyoshi Mitani, Ahmed Elhossany Elmarhomy Ibrahim, Luvsandorj Dulamjav, Enkhtumur Anu, Shohei Saitoh, Shiro Ishida and Yasuo Oyama 2017

[雑誌論文] Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocyte

Norio Kamemura, Keisuke Oyama, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama 2017

[雑誌論文] Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes

Keisuke Oyama, Norikazu Miyoshi and Yasuo Oyama 2017

[雑誌論文] Cetylpyridinium chloride at sublethal levels increases the susceptibility of rat thymic lymphocytes to oxidative stress

Hiroto Imai, Fumiya Kita, Sho Ikesugi, Masami Abe, Shizuka Sogabe, Yumiko Nishimura-Danjobara, Hajime Miura and Yasuo Oyama 2017

[雑誌論文] Zinc is a determinant of the cytotoxicity of Ziram, a dithiocarbamate fungicide, in rat thymic lymphocytes: Possible environmental risk

Yumiko Kanemoto-Kataoka, Tomohiro Oyama, Hitoshi Ishibashi and Yasuo Oyama 2017

[雑誌論文] Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive: Possible risk on lymphocytes

Maki Takeda, Keisuke Oyama, Norio Kamemura, Kaori Kanemaru, Keizo Yuasa, Kumio Yokoigawa and Yasuo Oyama 2017

[雑誌論文] Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes

Risa Kamae, Shoko Nojima, Kenji Akiyoshi, Shoki Setsu, Sari Honda, Toshiya Masuda and Yasuo Oyama 2017

[雑誌論文] Cytotoxic actions of 2, 2-dibromo-3-nitrilopropionamide, a biocide in hydraulic fracturing fluids, on rat thymocytes

Mizuki Ishikawa, Ryosuke Muraguchi, Ayako Azuma, Shogo Nawata, Tetsuya Katsuur, Mutsumi Miya, Tohru Naito and Yasuo Oyama 2016

[雑誌論文] Chlorhexidine possesses unique cytotoxic actions in rat thymic lymphocytes: Its relation with electrochemical property of membranes

Kayo Nonami, Shohei Saitoh, Yumiko Nishimura-Danjobara, Shiro Ishida and Yasuo Oyama 2016

[雑誌論文] Zinc increases vulnerability of rat thymic lymphocytes to arachidonic acid under in vitro conditions.

Eiko Niwa, Tsuyoshi Mitani, Shohei Saitoh, Kaori Kanemaru, Shiro Ishida, Kumio Yokoigawa and Yasuo Oyama 2016

[雑誌論文] Cytotoxic actions of N-(2,4,6-trichlorophenyl)maleimide (IT-354), an antifouling agent, in rat thymic lymphocytes

Eri Fukunaga, Shohei Saitoh, Yuya Kurumi, Yurie Ohiwa, Eri Kurozumi and Yasuo Oyama 2015

[雑誌論文] Cell death process induced by hydrogen peroxide is accelerated by clioquinol in rat thymocytes

Tomohiro Oyama, Eri Fukunaga and Yasuo Oyama 2015

[雑誌論文] Zn2+-dependence of the synergistic increase in rat thymocyte cell lethality caused by simultaneous application of 4,5-dichloro-2-octyl-4-isothiazolin-3-one (DCOIT) and H2O2

Shohei Saitoh, Eri Fukunaga, Hana Ohtani and Yasuo Oyama 2015

[雑誌論文] Increase in intracellular Ca2+ level by phenylsulfamide fungicides, tolylfluanid and dichlofluanid, in rat thymic lymphocytes

Eri Fukunaga, Kana Enma, Shohei Saitoh, Yumiko Nishimura-Danjyobara, Yasuo Oyama and Norio Akaike 2015

[雑誌論文] Effects of N,N-dimethyldodecylamine-N-oxide on some cellular parameters of rat thymocytes

Eri Fukunaga, Yurie Ohiwa, Mari Yamada, Ayaka Sumi, Masaya Satoh and Yasuo Oyama 2015

[雑誌論文] Modulation of excitatory synaptic transmission in rat hippocampal CA3 neurons by triphenyltin, an environmental pollutant

Masahito Wakita, Yasuo Oyama, Yuko Takase and Norio Akaike 2015

[雑誌論文] Elevation of intracellular Zn2+ level by 2-n-octyl-4-isothiazolin-3-one in rat thymocytes: An involvement of a temperature-sensitive Zn2+ pathway

Eri Fukunaga, Tomohiro Oyama and Yasuo Oyama 2015

[雑誌論文] Dithiocarbamate fungicides increase intracellular Zn2+ levels by increasing influx of Zn2+ in rat thymic lymphocytes

Yumiko Kanemoto-Kataoka, Tomohiro Oyama, Hitoshi Ishibashi and Yasuo Oyama 2015

[雑誌論文] Zn<sup>2+</sup>-dependent increase in cells with phosphatidylserine-exposed membranes after treatment with submicromolar concentrations of 2-<i>n</i>-octyl-4-isothiazolin-3-one in rat thymocytes

Eri Fukunaga, Sari Honda, Yuji Hashimoto, Yasuaki Tamaru, Shiro Ishida and Yasuo Oyama 2015

[雑誌論文] Elevation of the intracellular Zn2+ level by 2-n-octyl-4-isothiazolin-3-one in rat thymocytes: an involvement of a temperature-sensitive Zn2+ pathway

Eri Fukunaga, Tomohiro M. Oyama, Yasuo Oyama 2015

[雑誌論文] Changes in cellular thiol content and intracellular Zn2+ level by 1, 4-naphthoquinone in rat thymocytes

Eri Fukunaga, Shiro Ishida, Yasuo Oyama 2014

[雑誌論文] The paradoxical effect of 1,4-naphthoquinone on the process of cell death induced by hydrogen peroxide in rat thymocytes

Hana Ohtani, Eri Fukunaga, Yasuo Oyama, Shiro Ishida, Norio Akaike 2014