トップ研究者を探す分子機能に立脚した熱帯熱マラリア赤血球期ワクチン候補抗原の探索

分子機能に立脚した熱帯熱マラリア赤血球期ワクチン候補抗原の探索

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-26253026
研究種目 基盤研究(A)
研究分野 生物系
医歯薬学
基礎医学
寄生虫学(含衛生動物学)
研究機関 愛媛大学
代表研究者 坪井 敬文
研究分担者 高島 英造
研究協力者 森田 将之
研究期間 開始年月日 2014/4/1
研究期間 終了年度 2016
研究ステータス 完了 (2016/4/1)
配分額(合計) 40,820,000 (直接経費 :31,400,000、間接経費 :9,420,000)
配分額(履歴) 2016年度:10,920,000 (直接経費 :8,400,000、間接経費 :2,520,000)
2015年度:10,920,000 (直接経費 :8,400,000、間接経費 :2,520,000)
2014年度:18,980,000 (直接経費 :14,600,000、間接経費 :4,380,000)
キーワード マラリア
赤血球期ワクチン
コムギ無細胞法
コンビネーションワクチン

研究成果

[学会発表] Post-genome malaria vaccine research.

Tsuboi T 2017

[雑誌論文] Identification of Plasmodium falciparum reticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate.

Ntege EH, Arisue N, Ito D, Hasegawa T, Palacpac NM, Egwang TG, Horii T, Takashima E, Tsuboi T. 2016

[雑誌論文] Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA) binds human erythrocytes independent of Duffy antigen status.

Cheng Y, Lu F, Wang B, Li J, Han JH, Ito D, Kong DH, Jiang L, Wu J, Ha KS, Takashima E, Sattabongkot J, Cao J, Nyunt MH, Kyaw MP, Desai SA, Miller LH, Tsuboi T, Han ET. 2016

[学会発表] Reverse vaccinology approach: Postgenome malaria blood-stage vaccine candidate discovery.

Tsuboi T, Ntege EH, Takashima E, Morita M, Ito D, Cowman A. 2016

[学会発表] ポストゲノム生化学研究:マラリアワクチン研究の突破口

坪井敬文、高島英造、森田将之 2016

[雑誌論文] Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period.

McLean AR, Boel ME, McGready R, Ataide R, Drew D, Tsuboi T, Beeson JG, Nosten F, Simpson JA, Fowkes FJ. 2016

[雑誌論文] Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Menard R. 2016

[学会発表] Post-genome malaria vaccine candidate discovery by wheat germ cell-free system

Tsuboi T 2016

[学会発表] Approaches to malaria vaccine development.

Tsuboi T 2016

[雑誌論文] The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria.

Weaver R, Reiling L, Feng G, Drew DR, Mueller I, Siba PM, Tsuboi T, Richards JS, Fowkes FJ, Beeson JG. 2016

[学会発表] an integrated approach to tackling malaria in Uganda with special reference to novel malaria vaccine candidate discovery

Tsuboi T, Kanoi BN, Egwang TG, Horii T 2015

[学会発表] WGCFS: an innovative technology for post-genome malaria vaccine research

Tsuboi T 2015

[学会発表] ポストゲノムマラリアワクチン研究は宿主寄生体関係の総体的理解につながる

坪井敬文 2015

[学会発表] Pre-erythrocytic vaccines for malaria elimination

Tsuboi T 2015

[学会発表] Wheat germ cell-free protein synthesis system: an innovative technology for post-genome malaria vaccine candidate discovery

Tsuboi T 2014

[学会発表] Wheat germ cell-free protein synthesis system (WGCFS): a breakthrough for the post-genome malaria research

Tsuboi T 2014

[学会発表] Characterization of Plasmodium falciparum MAS170 as novel malaria blood-stage vaccine candidate

Sasaoka C, Sakamoto H, Ito D, Takeo S, Sattabongkot J, Takashima E, Tsuboi T 0

[学会発表] Wheat germ cell-free protein synthesis system (WGCFS): a breakthrough for the post-genome vivax malaria research

Tsuboi T, Takashima E, Ito D, Feng Lu, Cheng Y, Han ET 0

[学会発表] Immunoscreening of the target proteins contributing to growth inhibitory activity of human IgG against Plasmodium falciparum

Morita M, Takashima E, Kanoi BN, Miura K, Tsuboi T 0

[学会発表] Antibodies against a Plasmodium falciparum rhoptry neck protein PfRON12 inhibit merozoite invasion into erythrocytes

Ito D, Takashima E, Hatano S, Yamasaki T, Hasegawa T, Miura K, Thongkukiatkul A, Long CA, Sattabongkot J, Torii M, Tsuboi T 0

[学会発表] Rhoptry proteins are involved in sporozoite invasion of the salivary gland

Nozaki M, Ishino T, Tokunaga N, Tsuboi T, Torii M 0

[学会発表] Wheat germ cell-free protein synthesis system: an innovative technology for post-genome malaria vaccine candidate discovery

坪井敬文 0

[学会発表] Identification of the novel transmission-blocking vaccine target expressing on the surface of male gametes

Tachibana M, Torii M, Sudo M, Tsuboi T, Ishino T 0

[学会発表] Global Health Innovation through Partnership

Tsuboi T 0