研究成果

[学会発表] Ecological factors drive natural selection pressure affecting avian dioxin receptor genotypes

Hwang, J. H., Park, J. Y., Park, H. J., Bak, S. M., Hirano, M., Iwata, H., Park, Y. S. and Kim, E. Y. 2016

[学会発表] Transcriptome analysis to identify adverse outcome pathways mediated by the aryl hydrocarbon receptor in TCDD-ｔreated red seabream embryos

Iida, M., Fujii, S., Uhida, M., Nakamura, H., Kagami, Y., Agusa, T., Hirano, M., Bak, S. M., Kim, E. Y. and Iwata, H. 2016

[学会発表] Structural preference of OH-PCBs to activate the Baikal Seal estrogen receptors

Yoshinouchi, Y., Hirano, M., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H. 2016

[学会発表] Assessment of metabolic potential of polyhlorinated biphenyl congeners in the beagle dog liver by in vitro and in silico approaches

Yoo, J., Hirano, M., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H. 2016

[学会発表] Liver transcriptome analysis to assess the effects of prenatal exposure to bisphenol a of rat offspring

Hoa, T. N., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H. 2016

[学会発表] Hepatic transcriptome analysis to assess the effects of polychlorinated biphenyls on beagle dogs

Tamura, S., Yoo, J., Mizukawa, H., Agusa, T., Hirano, M., Eguchi A., Nomiyama, K., Tanabe, S., Kim, E. Y. and Iwata, H. 2016

[学会発表] Effect of prenatal exposure of BPA on the transcriptome in chicken embryos

Itoh, S., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H. 2016

[雑誌論文] Auto-induction mechanism of aryl hydrocarbon receptor 2 (AHR2) gene by TCDD-activated AHR1 AHR2 in the red seabream (Pagrus major)

Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H. and Kim, E. Y. 2016

[学会発表] Assessment of effects of dioxins in the Baikal seal (Pusa Sibirica) by proteome and transcriptome analyses

Lauan, M. C., Yoo, J., Agusa, T., Hirano, M., Kim, E. Y. and Iwata, H. 2016

[学会発表] Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome

Hirano, M., Uchida, M., Kusano, T., Arizono, K. and Iwata, H. 2016

[学会発表] Past, present, and future perspectives of environmental toxicology at Ehime University: advent of an era of the authentic animal study

Iwata, H. 2016

[学会発表] In silico and in vitro screening of the effects of PPCPs on mysid ecdysteroid receptor signaling

Hirano, M., Ohno, Y.　and Iwata, H. 2015

[学会発表] RNA-Seq analysis of the mysid crustacean transcriptome treated with naturally occurring 1,3,7-tribromodibenzo-p-dioxin.

Hirano, M., Uchida, M., Kusano, T., Arizono, K., Iwata, H. 2015

[学会発表] Hepatic cytochrome P450-dependent metabolic potency of polychlorinated biphenyls in the baikal seal (Pula sibirica)

Yoo, J., Hirano, M., Mizukawa, H., Nomiyama, K., Agusa, T., Kim, E. Y., Tanabe, S. and Iwata, H. 2015

[学会発表] 鳥類の化学物質感受性を規定する分子機序

岩田久人，平野将司， 金　恩英 2015

[学会発表] OH-PCBｓによるバイカルアザラシ　エストロゲン受容体α・β転写活性化能の評価

芳之内結加，平野将司，野見山桂，田辺信介，金恩英，岩田久人 2015

[学会発表] バイカルアザラシ　エストロゲン受容体を介したビスフェノール類によるアンタゴニスト作用の評価

芳之内結加、清水沙千子、李　鎮善、平野将司、鈴木賢一、中田晴彦、金　恩英、岩田久人 2015

[学会発表] In vitro and in silico assessment of transactivation potencies of baikal seal estrogen receptors

Yoshinouchi, Y., Shimizu, S., Lee, J. S., Hirano, M., Agusa, T., Suzuki, K. T., Nakata, H., Kim, E. Y. and Iwata, H. 2015

[学会発表] Hepatic proteome analysis of baikal seals contaminated with dioxins and related compounds

Lauan, M. C., Agusa, T., Hirano, M., Iwata, H., Kim, E. Y. and Yoo, J. 2015

[学会発表] The autoinduction mechanism of aryl hydrocarbon receptor 2 (AhR2) through TCDD-activated AhR1/2 in the red seabream (Pagrus major).

Bak, S.M., Kim, E.Y., Iida, M., Iwata, H. 2015

[学会発表] Relationship between mRNA expressionlevel and SNPs of As3MT in residents from arsenic-contaminated areas in Vietnam.

Agusa, T., Kunito, T., Tue, N.M., Lan, V.T., Minh, T.B., Trang, P.T., Fujihara, J., Takeshita, H., Takahashi, S., Viet, P.H., Tanabe, S., Iwata, H. 2015

[学会発表] Comparison of hepatic cytochrome P450-dependent metabolic potencies of polychlorinated biphenyls in the caniformia, the baikal seal and the beagle dog.

Yoo, J., Mizukawa, H., Nomiyama, K., Kim, E. Y., Tanabe, S. and Iwata, H. 2015

[学会発表] Identification of functional xenobiotic-responsive elements controlling AHR2 expression of red seabream (Pagrus major)

Bak, S. M., Iida, M., Soshilov, A. A., Denison, M. S., Iwata, H. and Kim, E. Y. 2015

[学会発表] Ecological factors affecting natural selection of avian AHR1 genotypes

Hwang, J. H., Park, H. J., Bak, S. M., Hirano, M., Iwata, H., Park, Y. S. and Kim, E. Y. 2015

[学会発表] Effects of prenatal exposure to bisphenol A on the liver transcriptome of rat offspring

Hoa, N. T., Yamamoto, K., Agusa, T., Hirano, M., Ochiai, M., Kim, E. Y. and Iwata, H. 2015

[学会発表] Strain-differences in the proteome of dioxin-sensitive and -resistant mice treated with 2,3,7,8-tetrabromodibenzo-p-dioxin.

Nguyen, T., Lauan, M., Yoo, J., Iida, M., Agusa, T., Kim, E.Y., Miyazaki, T., Nose, M., Iwata, H. 2015

[雑誌論文] Association of XRCC1 polymorphisms with arsenic methylation.

Fujiwara, J., Yasuda, T., Iwata, H., Tanabe, S., Takeshita, H. 2015

[雑誌論文] Transient suppression of AHR activity in early red seabream embryos does not prevent the disruption of peripheral nerve projection by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Iida, M., Bak, S.M., Murkami, Y., Kim, E.Y., Iwata, H. 2014

[学会発表] キタオットセイ（Callorhinus ursinus）の肝臓における水銀結合タンパク質の探索

阿草哲郎，安木進也，池本徳孝，國頭　恭，馬場徳寿，田辺信介，岩田久人 2014

[学会発表] バイカルアザラシ (Pusa sibirica) における水酸化PCBsの毒性影響評価

野見山桂、平川周作、江口哲史、今枝大輔、Yoo Jean、国末達也、岩田久人、田辺信介 2014

[学会発表] AS3MT遺伝子多型と無機ヒ素のメチル化能力との関係

阿草哲郎, 國頭 恭, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 藤原純子, 竹下治男, 高橋 真, Pham Hung Viet, 田辺信介, 岩田久人 2014

[学会発表] DDTs ・ビスフェノール類によるバイカルザラシ・マウスエストロゲン受容体転写活性化能の評価

芳之内結加，清水沙千子，李　鎮善，平野将司，阿草哲郎，鈴木賢一，中田晴彦，金　恩英，岩田久人 2014

[学会発表] Effects of a naturally occurring dioxin, 1,3,7-tribromodibenzo-p-dioxin on the mysid transcriptome

Hirano, M., Uchida, M., Kusano, T., Arizono, K., Iwata, H. 2014

[学会発表] ウミガメ類におけるヒ素化合物の蓄積特性

阿草哲郎、高木　梢、Todd W. Miller、久保田領志、阿南弥寿美、岩田久人、田辺信介 2014

[学会発表] 海棲高等動物はどのように水銀を解毒しているのか？

阿草哲郎, 安木進也, 池本徳孝, 國頭 恭, 馬場徳寿, 田辺信介, 岩田久人 2014

[雑誌論文] Effects of persistent organochlorine exposure on the liver transcriptome of the common minke whale (Balaenoptera acutorostrata) from the North Pacific.

Niimi, S., Imoto, M., Kunisue, T., Watanabe, M.X., Kim, E.Y., Nakayama, K., Yasunaga, G., Fujise, Y., Tanabe, S., Iwata, H. 2014

[学会発表] Isoform specific induction of aryl hyrocarbon receptor by TCDD in the red seabream (Pagrus major)

Bak, S.M., Iida, M., Iwata, H., Kim, E.Y. 2014

[学会発表] In vitro and in silico assessment of transactivation potencies of Baikal seal estrogen receptors αand β by persistent organic pollutants and bisphenols

Yoshinouchi, Y., Shimizu, S., Suzuki, K., Lee, J.S., Nakata, H., Hirano, M., Kim, E.Y., Agusa, T., Iwata, H. 2014

[学会発表] Ecological factors as pressure of natural selection of AhR genotypes in avian species

Hwang, J.H., Park, H.J., Park, J.Y., Bak, S.M., Park, Y.S., Hirano, M., Kim, E.Y., Iwata, H. 2014

[学会発表] ポリ塩化ビフェニル（PCBs）曝露によるイヌ異物代謝酵素シトクロムP450への影響

田村沙弥、Yoo Jean、水川葉月、阿草哲郎、平野将司、野見山桂、田辺信介、金　恩英、岩田久人 2014

[学会発表] Effects of polychlorinated biphenyls on the expression of cytochrome P450s in beagle dogs

Tamura, S., Yoo, J., Nomiyama, K., Mizukawa, H., Tanabe, S., Agusa, T., Kim, E.Y., Hirano, M., Iwata, H. 2014

[学会発表] Functional characterization of the clathrin as a novel regulator of ecdysone receptor signaling pathway

Hirano, M., Suzuki, K.T., Iwata、H. 2014

[学会発表] バイカルアザラシ エストロゲン受容体α・β転写活性化能の評価：種差とE2誘導等価係数

芳之内結加、清水沙千子、李　鎮善、平野将司、阿草哲郎、鈴木賢一、中田晴彦、金　恩英、岩田久人 2014

[学会発表] パスウェイ解析によるTCDD曝露したマダイ胚のトランスクリプトームへの影響評価

飯田　緑、藤井　聡、内田雅也、中村　浩、鏡　良弘、Bak Su-Min、金　恩英、岩田久人 2014

[学会発表] バイカルアザラシ　エストロゲン受容体α・β転写活性化能の評価：in vitro ・ in silico法によるリガンド作用機序の解明

芳之内結加、清水沙千子、李　鎮善、平野将司、阿草哲郎、鈴木賢一、中田晴彦、金　恩英、岩田久人 2014

[学会発表] Identification of amino acid residues critical for ligand binding and transactivation in ecdysone receptor

Hirano, M., Ishibashi, H., Kim, E. Y., Arizono, K. and Iwata, H. 2013

[学会発表] In vitro approach to predict AHR-mediated CYP1A induction by dioxins in cormorant population

Iwata, H., Thuruthippalli, L. M., Kubota, A. and Kim, E. Y. 2013

[学会発表] Effect of aryl hydrocarbon receptor variants and hnRNPA2/B1 on dioxin-induced cyp1a1 transactivation in MRL/lpr and C3H/lpr

Cho, S. W., Suzuki, K. I., Miura, Y., Watanabe, M., Miyazaki, T., Nose, M., Iwata, H. and Kim, E. Y. 2013

[学会発表] ホッキョクグマのシトクロムP450 1Aおよび2BによるPCBs代謝能力の評価

古池 幸，平野将司，鈴木賢一，Yoo Jean，阿草哲郎，Thomas J. Evans，Kurunthachalam Kannan，岩田久人 2013

[学会発表] Functional characterization of aryl hydrocarbon receptor from the polar bear (Ursus maritimus)

Hwang, J. H., Jeong, L. R., Kannan, K., Evans T. J., Iwata, H. and Kim, E. Y. 2013

[学会発表] Effects of aryl hydrocarbon receptor and transcriptional co-factor(s) on transactivation in MRL/lpr and C3H/lpr mouse strains

Cho, S. W., Kim, E. Y., Suzuki, K., Miura, Y., Iwata, H., Miyazaki, T. and Nose, M. 2013

[学会発表] Identification of quantitative trait loci (QTL) associated with inorganic arsenic metabolism using recombinant inbred strains of mice

Agusa, T., Komori, H., Soga, Y., Nose, M., Mori, S., Kubota, R., Tanabe, S. and Iwata, H. 2013

[学会発表] Isoform-specific responses of aryl hydrocarbon receptor to dioxins in red seabream (Pagrus major)

Bak, S. M., Kim, E. Y., Iida, M. and Iwata, H. 2013

[学会発表] Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBs) in the Baikal seals and implication from toxicogenomic approach

Nomiyama, K., Eguchi, A., Hirakawa, S., Kanbara, C., Imaeda, D., Kim, E. Y., Iwata, H. and Tanabe, S. 2013

[学会発表] Homology modeling and ligand docking simulations of avian AhRs to decipher the interspecies differences in responses to dioxins

Hirano, M., Kim, E. Y., Bak, S. M. and Iwata, H. 2013

[学会発表] TCDD曝露したマダイ胚のトランスクリプトーム解析

飯田 緑，藤井 聡，内田雅也，中村 浩，鏡 良弘，Bak Su-Min，Kim Eun-Young，島 康洋，岩田久人 2013

[学会発表] Isoform-specific transactivation and autoinduction of aryl hydrocarbon receptors by dioxins in the red seabream (Pagrus major)

Bak, S. M., Iida, M., Iwata, H. and Kim, E. Y. 2013

[学会発表] In vitro and In silico analyses to predict the effects of environmental chemicals through the mysid ecdysteroid receptor signaling pathway

Hirano, M., Ishibashi, H., Kim, E. Y., Arizono, K. and Iwata, H. 2013

[学会発表] Identification of cytochrome P450 enzymes in phenobarbital-treated mouse liver microsomes using 2-DE and MALDI-TOF/TOF

Lauan, M. C., Suzuki, K., Agusa, T. and Iwata, H. 2013

[学会発表] Identification and functional characterization of a novel chicken aryl hydrocarbon receptor isoform, 2nd AHR1

Lee, J. S., Iwabuchi, K., Nomaru, K., Nagahama, N., Kim, E. Y. and Iwata, H. 2013

[学会発表] In silico 解析による化学物質と核内受容体・シトクロムP450の相互作用の評価

岩田久人，平野将司， Kim Eun-Young 2013

[学会発表] Thyroid hormone-mediated effects of dioxins in wild Baikal seals (Pusa sibirica)

Iwata, H., Hirakawa, S., Eguchi, A., Imaeda, D., Kunisue, T., Kim, E. Y., Kannan, K., Petrov, E. A., Batoev, V. B. and Tanabe, S. 2013

[学会発表] In silico analysis of avian AHRs to decipher the molecular basis for interspecies diffrences in responses to dioxins

Hirano, M., Bak, S. M., Iwata, H. and Kim, E. Y. 2013

[学会発表] 海棲哺乳類の肝臓におけるHg結合タンパク質

阿草哲郎，安木進也，池本徳孝，國頭　恭，馬場徳寿，田辺信介，岩田久人 0