トップ研究者を探す脂肪細胞由来のマイクロRNAを介した血管リモデリング制御機構の解析

脂肪細胞由来のマイクロRNAを介した血管リモデリング制御機構の解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-25461131
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 徳島大学
代表研究者 八木 秀介
研究分担者 佐田 政隆
研究分担者 石田 昌義
研究期間 開始年月日 2013/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額(合計) 5,070,000 (直接経費 :3,900,000、間接経費 :1,170,000)
配分額(履歴) 2015年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2014年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2013年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード マイクロRNA
脂肪細胞
マイクロRNA
平滑筋細胞

研究成果

[雑誌論文] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.

Yoshida, S., Aihara, K., Ikeda, Y., Sumitomo-Ueda, Y., Uemoto, R., Ishikawa, K., Ise, T., Yagi, S., Iwase, T., Mouri, Y., Sakari, M., Matsumoto, T., Takeyama, K., Akaike, M., Matsumoto, M., Sata, M., Walsh, K., Kato, K., Matsumoto, T. 2015

[雑誌論文] Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome

Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Nishimoto S, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2015

[雑誌論文] Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus.

Yagi S, Aihara K, Akaike M, Fukuda D, Salim HM, Ishida M, Matsuura T, Ise T, Yamaguchi K, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Matsumoto T, Sata M. 2015

[雑誌論文] Impact of indoxyl sulfate, a uremic toxin, on non-culprit coronary plaque composition assessed by integrated backscatter intravascular ultrasound.

Yamazaki H, Yamaguchi K, Soeki T, Wakatsuki T, Niki T, Taketani Y, Kitaoka A, Kusunose K, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Sata M. 2015

[雑誌論文] Plasma MicroRNA-100 Is Associated With Coronary Plaque Vulnerability

Soeki T, Yamaguchi K, Niki T, Uematsu E, Bando S, Matsuura T, Ise T, Kenya K, Hotchi J, Tobiume T, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M. 2015

[雑誌論文] Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice.

Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M. 2015

[雑誌論文] Serial Imaging Changes During Treatment of IgG4-related Disease with Multiple Pseudo Tumors.

Kusunose K, Hotchi J, Takagawa Y, Nishio S, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Soeki T, Wakatsuki T, Sata M. 2015

[雑誌論文] Effects of Docosahexaenoic Acid on the Endothelial Function in Patients with Coronary Artery Disease

Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2015

[雑誌論文] Effects of docosahexaenoic acid on the endothelial function in patients with coronary artery disease.

Yagi S, Aihara K, Fukuda D, Takashima A, Hara T, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2015

[雑誌論文] Increase in serum triglyceride was associated with coronary plaque vulnerability in a patient with rheumatoid arthritis.

Yagi S, Fujimura M, Akaike M, Aihara K, Iwase T, Tada M, Sumitomo-Ueda Y, Ise T, Yamaguchi K, Wakatsuki T, Matsumoto T, Sata M. 2014

[雑誌論文] Cardiac Rehabilitation Reduces Serum Levels of Oxidized Low-Density Lipoprotein.

Takashima A, Ise T, Yagi S, Iwase T, Kimura S, Ueda Y, Nishikawa K, Ishii A, Niki T, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Katoh S, Akaike M, Sata M. 2014

[雑誌論文] High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients.

Yagi S, Aihara K, Kondo T, Endo I, Hotchi J, Ise T, Iwase T, Akaike M, Matsumoto T, Sata M. 2014

[雑誌論文] Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease.

Yagi S, Hara T, Ueno R, Aihara K, Fukuda D, Takashima A, Hotchi J, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2014

[雑誌論文] Effect of combination tablets containing amlodipine 10 mg and irbesartan 100 mg on blood pressure and cardiovascular risk factors in patients with hypertension.

Yagi S, Takashima A, Mitsugi M, Wada T, Hotchi J, Aihara K, Hara T, Ishida M, Fukuda D, Ise T, Yamaguchi K, Tobiume T, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M. 2014

[学会発表] Post-transcriptional regulation of adiponectin by microRNA-378 in adipose tissue: a novel mechanism for hypoadiponectinemia.

Shimabukuro M, Ishida M, Yagi S, Fukuda D, Soeki T, Sata M. 0