トップ研究者を探すインターロイキン17産生ヘルパーT細胞を制御する新規ヘルパーT細胞の応用可能性

インターロイキン17産生ヘルパーT細胞を制御する新規ヘルパーT細胞の応用可能性

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-25460592
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
免疫学
研究機関 香川大学
代表研究者 仁木 敏朗
研究期間 開始年月日 2013/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額(合計) 4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
配分額(履歴) 2015年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2014年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
2013年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード ガレクチン
自己免疫疾患
ガン
アレルギー
免疫制御
ガレクチン9
糖鎖
レクチン
炎症
免疫
感染症
制御性T細胞

研究成果

[雑誌論文] Galectin-9: An anticancer molecule for gallbladder carcinoma.

Tadokoro T, Morishita A, Fujihara S, Iwama H, Niki T, Fujita K, Akashi E, Mimura S, Oura K, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Himoto T, Hirashima M, Masaki T. 2016

[雑誌論文] Galectin-9 suppresses the proliferation of gastric cancer cells in vitro.

Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H, Mori H, Niki T, Hirashima M, Masaki T. 2016

[雑誌論文] Acute Liver Failure Study Group. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure.

Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM 2016

[雑誌論文] Development of Point-of-Care Testing for Disaster-Related Infectious Diseases

Hattori T, Chagan-Yasutan H, Shiratori B, Egawa S, Izumi T, Kubo T, Nakajima C, Suzuki Y, Niki T, Alisjahbana B, Telan E. 2016

[雑誌論文] MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.

Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T. 2015

[学会発表] Potential functions of galectin-9 in mucosal immunity.

Niki T, Fukunaga H, Natori T, Hara A,Takeda K, Ezaki T. 2015

[雑誌論文] Evaluation of matricellular proteins in systemic and local immune response to Mycobacterium tuberculosis infection.

Hasibuan FM, Shiratori B, Senoputra MA, Chagan-Yasutan H, Koesoemadinata RC, Apriani L, Takahashi Y, Niki T, Alisjahbana B, Hattori T. 2015

[雑誌論文] Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.

Lhuillier C, Barjon C, Niki T, Gelin A, Praz F, Morales O, Souquere S, Hirashima M, Wei M, Dellis O, Busson P. 2015

[雑誌論文] Effect of nasopharyngeal carcinoma-derived exosomes on human regulatory T cells.

Mrizak D, Martin N, Barjon C, Jimenez-Pailhes AS, Mustapha R, Niki T, Guigay J, Pancré V, de Launoit Y, Busson P, Moralès O, Delhem N. 2015

[雑誌論文] The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Wiersma VR, de Bruyn M, Wei Y, van Ginkel RJ, Hirashima M, Niki T, Nishi N, Zhou J, Pouwels SD, Samplonius DF, Nijman HW, Eggleton P, Helfrich W, Bremer E. 2015

[雑誌論文] Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest.

Kobayashi K, Morishita A, Iwama H, Fujita K, Okura R, Fujihara S, Yamashita T, Fujimori T, Kato K, Kamada H, Niki T, Hirashima M, Okano K, Suzuki Y, Masaki T. 2015

[雑誌論文] Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo.

Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T. 2015

[雑誌論文] Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

Zhang Q, Luan H, Wang L, He F, Zhou H, Xu X, Li X, Xu Q, Niki T, Hirashima M, Xu G, Lv Y, Yuan J. 2014

[雑誌論文] Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies.

Madireddi S, Eun SY, Lee SW, Nemčovičová I, Mehta AK, Zajonc DM, Nishi N, Niki T, Hirashima M, Croft M. 2014

[雑誌論文] Elevated OPN, IP-10, and neutrophilia in loop-mediated isothermal amplification confirmed tuberculosis patients.

Shiratori B, Leano S, Nakajima C, Chagan-Yasutan H, Niki T, Ashino Y, Suzuki Y, Telan E, Hattori T. 2014

[雑誌論文] Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.

Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC. 2014

[雑誌論文] Preventive effect of galectin-9 on double-stranded RNA-induced airway hyperresponsiveness in an exacerbation model of mite antigen-induced asthma in mice.

Katoh S, Shimizu H, Obase Y, Oomizu S, Niki T, Ikeda M, Mouri K, Kobashi Y, Hirashima M, Oka M. 2013

[雑誌論文] Galectin-9 in cancer therapy. Recent Pat Endocr Metab Immune Drug Discov.

Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T. 2013

[雑誌論文] Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M. 2013

[雑誌論文] Galectin-9 prolongs the survival of septic mice by expanding tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages.

Kadowaki T, Morishita A, Niki T, Hara J, Sato M, Tani J, Miyoshi H, Yoneyama H, Masaki T, Hattori T, Matsukawa A, Hirashima M. 2013

[雑誌論文] Galectin-9 in combination with rapamycin induces cardiac allograft tolerance in mice.

Cai L, Zhou H, Fang Z, Yuan J, Niki T, Hirashima M, He W, Chen ZK. 2013