トップ›研究者を探す›マクロファージTLR9を介した新しいインスリン抵抗性発現メカニズムの解明

マクロファージTLR9を介した新しいインスリン抵抗性発現メカニズムの解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-25460369
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
基礎医学
医化学一般
研究機関 徳島大学
代表研究者 福田 大受
研究分担者 佐田 政隆
研究期間 開始年月日 2013/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額（合計） 5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
配分額（履歴） 2015年度：1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2014年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2013年度：2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード 炎症
マクロファージ
インスリン抵抗性
ＴＬＲ９
肥満
脂肪

研究成果

[学会発表] Critical Role in Bone Marrow Protease-Activated Receptor-2 in the Pathogenesis of Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice

Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] TLR9の活性化は虚血肢における炎症を増強し血流改善を遅延させる

六車隆太郎、福田大受、西本幸子、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆 2016

[学会発表] Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in apolipoprotein-E deficient mice through GLP-1 dependent and independent manners

Hotimah Masdan Salim、福田大受、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆 2016

[学会発表] Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice through GLP-1 Dependent Manner.

Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] ω3系不飽和脂肪酸の脂質ラフト構造変化を介した抗動脈硬化作用の解明

高島啓、福田大受、田中君枝、東邦康智、平田陽一郎、山田博胤、添木武、若槻哲三、島袋充生、佐田政隆 2016

[雑誌論文] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Normoglycemic Apolipoprotein-E Deficient Mice.

Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] Reduced Ratio of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid is Associated with Early Onset of Acute Coronary Syndrome.

Yagi S, Aihara K, Fukuda D, Takashima A, Bando M, Hara T, Ise T, Kusunose K, Yamaguchi K, Tobiume T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Akaike M, Sata M 2016

[学会発表] Cell-Free DNA/Toll-like Receptor 9 Axis Plays a Pivotal Role in Metabolic Disorder-induced Chronic Inflammation, Leading to Atherogenesis and Insulin Resistance.

Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M 2016

[学会発表] 動脈硬化におけるマクロファージTLR9の役割

西本幸子、福田大受、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、阪上浩、島袋充生、佐田政隆 2016

[学会発表] Deletion of Toll-Like Receptor 9 Prevented Atherosclerosis Induced by Angiotensin II

Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2016

[学会発表] 動脈硬化発症におけるマクロファージToll-like receptor 9の役割

西本幸子、福田大受、阪上浩、島袋充生、佐田政隆 2015

[学会発表] 自己遊離核酸断片の認識を介した血管の炎症と動脈硬化発症メカニズム

福田大受、西本幸子、東邦康智、田中君枝、平田陽一郎、八木秀介、添木武、島袋充生、佐田政隆 2015

[学会発表] Inhibition of Activated Factor X Attenuates Vascular Inflammation and Atherosclerosis in ApoE-deficient Mice

Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M 2015

[学会発表] Hematopoietic Protease-activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in ApoE-Deficient Mice

Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M. 2015

[学会発表] FXa - PAR-2経路は血管の慢性炎症を惹起し動脈硬化を促進する

原知也、福田大受、田中君枝、東邦康智、平田陽一郎、八木秀介、添木 武、島袋充生、佐田政隆 2015

[学会発表] 活性型第X凝固因子によるマクロファージ活性化を介した新しい動脈硬化進展機序の検討

原知也、福田大受、田中君枝、東邦康智、平田陽一郎、八木秀介、山田博胤、添木武、若槻哲三、島袋充生、佐田政隆 2015

[雑誌論文] Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis.

Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M 2015

[学会発表] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and the Development of Atherosclerosis in Normoglycemic Apolipoprotein-E Deficient Mice

Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M 2015

[学会発表] Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, Ameliorates Endothelial Dysfunction and Atherogenesis in Apolipoprotein-e Deficient Mice Through GLP-1 Dependent and Independent Manners

Salim HM, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Shimabukuro M, Sata M. 2015

[学会発表] Toll-like Receptor 9 Plays a Pivotal Role in Angiotensin II-induced Atherosclerosis

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M. 2015

[学会発表] N-3 Polyunsaturated Fatty Acids Inhibit Inflammatory Responses in Macrophages by the Reduction of Toll-like Receptor 4 Expression in Lipid Rafts, Leading to the Suppression of Atherogenesis in Apolipoprotein E Deficient Mice

Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M 2015

[学会発表] The activation of toll-like receptor 9 deteriorates blood flow recovery after hind-limb ischemia.

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M 2015

[学会発表] Inhibition of Activated Factor X Attenuates Neointima Formation after Wire-Mediated Vascular Injury.

Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M 2015

[学会発表] Macrophage Toll-like receptor 9 Signaling Contributes to the Development of Insulin Resistance through the Promotion of Inflammation in Adipose Tissue

Sachiko Nishimoto, Daiju Fukuda, Michio Shimabukuro, Masayoshi Ishida, Sachiko Matsumoto, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Yutaka Nakaya, Masataka Sata 2013

[学会発表] Genetic ablation of TLR9 improves insulin resistance through macrophage accumulation in adipose tissue

Sachiko Nishimoto, Daiju Fukuda, Michio Shimabukuro, Masayoshi Ishida, Sachiko Matsumoto, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Yutaka Nakaya, Masataka Sata 2013

[学会発表] Genetic Deletion of Toll-like Receptor 9 Accelerates Blood Flow Recovery after Hindlimb Ischemia.

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Yagi S, Soeki T, Sakaue H, Shimabukuro M, Sata M. 0