トップ›研究者を探す›心拍同期制御を用いた補助人工心臓による広範囲心筋梗塞に対する新しい治療法の確立

心拍同期制御を用いた補助人工心臓による広範囲心筋梗塞に対する新しい治療法の確立

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-25293294
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
外科系臨床医学
心臓血管外科学
研究機関 大阪大学
地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所)
代表研究者 西村 隆
研究分担者 巽 英介
研究分担者 許 俊鋭
研究期間 開始年月日 2013/4/1
研究期間 終了年度 2018
研究ステータス 完了 (2018/4/1)
配分額（合計） 17,810,000 (直接経費 :13,700,000、間接経費 :4,110,000)
配分額（履歴） 2017年度：3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
2016年度：3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
2015年度：3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
2014年度：3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
2013年度：3,770,000 (直接経費 :2,900,000、間接経費 :870,000)
キーワード 補助人工心臓
心拍同期制御
Bridge to Recovery
広範囲心筋梗塞
制御
心不全
右心不全
von Willebrand factor
冠動脈外科学
心拍同期制御システム

研究成果

[雑誌論文] Miniaturized centrifugal ventricular assist device for bridge to decision: preclinical chronic study in a bovine model.

Shimamura J, Mizuno T, Takewa Y, Tsukiya T, Naito N, Akiyama D, Iiduka K, Katagiri N, Nishimura T, Ono M, Tatsumi E. 2019

[学会発表] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in left ventricular assist device support

Iizuka K, Akiyama D, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Tatsumi E 2018

[学会発表] Native heart load control system (NHLCS) for continuous-flow LVAD: a comprehensive review and updates

Nishimura T, Shimamura J, Akiyama D, Iizuka K, Naito N, Date K, Umeki A, Ando M, Kishimoto S, Kishimoto Y, Arakawa M, Mizuno T., Tsukiya T, Takewa Y, Ono M, Tatsumi E 2018

[雑誌論文] Accurate Method of Quantification of Aortic Insufficiency During Left Ventricular Assist Device Support by Thermodilution Analysis: Proof of Concept and Validation by a Mock Circulatory System.

Akiyama D, Nishimura T, Sumikura H, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E. 2018

[雑誌論文] Rotational speed modulation used with continuous-flow left ventricular assist device provides good pulsatility.

Naito N, Nishimura T, Iizuka K, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E. 2018

[学会発表] Electrocardiogram-synchronized rotational speed modulation system can reduce the recirculation due to aortic insufficiency in LVAD support

Akiyama D, Nishimura T, Iizuka K, Mizuno T, Tsukiya T, Takewa Y, Ono M, Tatsumi E 2018

[学会発表] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support

Akiyama D, Nishimura T, Tatsumi E 2017

[学会発表] Control of LVADs: Native Heart Load Control System.

Nishimura T 2017

[雑誌論文] Novel Rotational Speed Modulation System Used With Venoarterial Extracorporeal Membrane Oxygenation.

Naito N, Nishimura T, Iizuka K, Fujii Y, Takewa Y, Umeki A, Ando M, Ono M, Tatsumi E. 2017

[学会発表] ECG-synchronized rotational speed change system has preventive effect on right heart failure during continuous-flow left ventricular assist device support

Akiyama D, Nishimura T, Tatsumi E 2017

[学会発表] The current situation of NHLCS

Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Kishimoto S, Date K, Naito N, Akiyama D, Iizuka K, Tatsumi E 2017

[学会発表] Development of accurate quantification method of aortic insufficiency during LVAD by thermodilution technique

Akiyama D, Nishimura T, Tatsumi E 2017

[雑誌論文] Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device

Date K, Nishimura T, Arakawa M, Takewa Y, Kishimoto S, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E 2017

[雑誌論文] Novel control system to prevent right ventricular failure induced by rotary blood pump

荒川衛 西村隆 武輪能明 巽英介 2016

[雑誌論文] Effects of feeding state on anticoagulation in adult goats treated with warfarin

Date K, Kishimoto S, Fujii Y, Togo K, Kakut Y, Mizuno T, Tsukiya T, Takewa Y, Nishimura T, Ono M, Tatsumi E 2016

[雑誌論文] Pulsatile support using a rotary left ventricular assist device with an electrocardiography-synchronized rotational speed control mode for tracking heart rate variability

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Date K, Kyo S, Adachi H, Tatsumi E 2016

[雑誌論文] Shifting the pulsatility by increasing the change in rotational speed for a rotary LVAD using a native heart load control system

Date K, Nishimura T, Takewa Y, Kishimoto S, Arakawa M, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E 2016

[雑誌論文] Shifting the pulsatility by increasing the change in rotational speed for a rotary LVAD using a native heart load control system.

Date K, Nishimura T, Takewa Y, Kishimoto S, Arakawa M, Umeki A, Ando M, Mizuno T, Tsukiya T, Ono M, Tatsumi E. 2016

[学会発表] Control of mitral regurgitation by a continuous-flow left ventricular assist device with a native heart control system

Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E 2015

[学会発表] Continuous-flow LVAD control with cardiac cycle synchronization

Nishimura T, Naito N, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E 2015

[学会発表] 定常流型左室補助人工心臓を用いた自己心拍同期システムの冠血流量の増加効果と左室仕事量の軽減効果

荒川　衛，西村　隆，武輪能明，梅木昭秀，安藤政彦，岸本祐一郎，岸本　諭，藤井　豊，安達秀雄，巽　英介 2015

[学会発表] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響

内藤敬嗣，西村　隆，岸本　諭，水野敏秀，武輪能明，樋口（江浦）由佳，小亀浩市，宮田敏行，小野　稔，巽　英介 2015

[雑誌論文] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models

梅木昭秀、西村　隆、武輪能明、安藤政彦、荒川　衛、岸本祐一郎、築谷朋典、水野敏秀、許　俊鋭、小野　稔、妙中義之、巽　英介 2015

[学会発表] What is an optimal setting of continuous-flow left ventricular assist device for severe mitral regurgitation?

Naito N, Nishimura T, Kishimoto S, Takewa Y, Ono M, Tatsumi E 2015

[学会発表] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムが僧帽弁閉鎖不全症に及ぼす影響

内藤敬嗣，西村　隆，武輪能明，岸本　諭，伊達数馬，梅木昭秀，安藤政彦，小野　稔，巽　英介 2015

[学会発表] Influence of a rotational speed modulation of an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand's factor dynamics

Naito N, Nishimura T, Kishimoto S, Mizuno T, Takewa Y, Ehara-Higuchi Y, Kokame K, Ono M, Tatsumi E 2015

[雑誌論文] Novel control system to prevent right ventricular failure induced by rotary blood pump

Arakawa, M; Nishimura, T; Takewa, Y; Umeki, A; Ando, M; Kishimoto, Y; Fujii, Y; Kyo, S; Adachi, H; Tatsumi, E 2014

[雑誌論文] Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance

Kishimoto, S; Date, K; Arakawa, M; Takewa, Y; Nishimura, T; Tsukiya, T; Mizuno, T; Katagiri, N; Kakuta, Y; Ogawa, D; Nishimura, M; Tatsumi, E 2014

[雑誌論文] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Adachi H, Tatsumi E. 2014

[雑誌論文] Novel control system to prevent right ventricular failure induced by rotary blood pump.

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Fujii Y, Kyo S, Adachi H, Tatsumi E 2014

[雑誌論文] Change in myocardial oxygen consumption employing continuous-flow LVAD with cardiac beat synchronizing system, in acute ischemic heart failure models.

Umeki A1, Nishimura T, Takewa Y, Ando M, Arakawa M, Kishimoto Y, Tsukiya T, Mizuno T, Kyo S, Ono M, Taenaka Y, Tatsumi E 2013

[学会発表] A non-invasive assessment of cardiac function during continuous-flow LVAD support by HRV analysis

Kishimoto S, Kishimoto Y, Ohnuma K, Arakawa M, Date K, Takewa Y, Nishimura M, Tatsumi E 2013

[学会発表] Enchantment of the myocardial perfusion by a novel cardiac cycle-synchronized rotation control mode in a continuous-flow in chronic ischemic heart failure model

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Date K, Atsuta Y, Fujii Y, Kishimoto S, Kyo S, Adachi H, Tatsumi E 2013

[学会発表] The potentially of non-synchronized pulsatile mode with a rotary LVAD by a native heart load control system

Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E 2013

[学会発表] The effect or continuous-flow LVAD control with cardiac cycle synchronization

Nishimura T, Takewa Y, Ando M, Umeki A, Arakawa M, Kishimoto Y, Date K, Tatsumi E 2013

[雑誌論文] Development of a novel drive mode to prevent aortic insufficiency during continuous-flow LVAD support by synchronizing rotational speed with heartbeat

Kishimoto Y1, Takewa Y, Arakawa M, Umeki A, Ando M, Nishimura T, Fujii Y, Mizuno T, Nishimura M, Tatsumi E 2013

[学会発表] Longtime pulsatile control using a rotary blood pump with a newly developed electrocardiogram synchronized rotational speed control system

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Yamazaki K, Kyo S, Adachi H, Tatsumi E 2013

[学会発表] The difference between front load and delay load in the pulsatile mode with a rotary LVAD by a native heart load control system

Date K, Arakawa M, Takewa Y, Nishimura T, Kishimoto S, Kishimoto Y, Umeki A, Ando M, Kyo S, Ono M, Tatsumi E 2013

[学会発表] The safe program for a newly developed electrocardiogram-synchronized rotational speed control mode with continuous-flow left ventricular assist device

Arakawa M, Nishimura T, Takewa Y, Umeki A, Ando M, Kishimoto Y, Kishimoto S, Fujii Y, Kyo S, Adachi H, Tatsumi E 2013

[学会発表] 定常流型左室補助人工心臓に用いる自己心拍数同期回転数制御システムが術後慢性期に心拍数に及ぼす影響

伊達　数馬、西村 隆、武輪 能明、岸本 諭、荒川 衛、梅木 昭秀、安藤 雅彦、水野 敏秀、築谷 朋典、小野 稔、巽 英介 0

[学会発表] Cotrol of left ventricular load and pulsatility by a continuous flow left ventricular assist device with a Native Heart Load Control System in a chronic awake phase

Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi 0

[学会発表] The comparison between synchronization and non-synchronization with cardiac beat under pulsatile mode with a rotary LVAD by a Native Heart Load Control System

Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Minoru Ono, Eisuke Tatsumi 0

[学会発表] Alternation of left ventricular load by a continuous-flow left ventricular assist device with a Native Heart Load Control System in chronic awake phase

Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi 0

[学会発表] What is the optimal difference of the change in the rotational speed with a rotary LVAD by a Native Heart Load Control System?

Kazuma Date, Takashi Nishimura, Yoshiaki Takewa, Satoru Kishimoto, Mamoru Arakawa, Akihide Umeki, Masahiko Ando, Toshihide Mizuno, Tomonori Tsukiya, Minoru Ono, Eisuke Tatsumi 0