トップ›研究者を探す›根本的治療法確立のための遺伝性自己免疫疾患の病態解明

根本的治療法確立のための遺伝性自己免疫疾患の病態解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-25293223
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
膠原病・アレルギー内科学
研究機関 徳島大学
代表研究者 松本 満
研究分担者 西嶋 仁
研究分担者 毛利 安宏
研究期間 開始年月日 2013/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額（合計） 18,460,000 (直接経費 :14,200,000、間接経費 :4,260,000)
配分額（履歴） 2015年度：6,240,000 (直接経費 :4,800,000、間接経費 :1,440,000)
2014年度：5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
2013年度：6,890,000 (直接経費 :5,300,000、間接経費 :1,590,000)
キーワード AIRE
thymus
autoimmunity
胸腺髄質上皮細胞
Aire
ノックインマウス
自己免疫疾患
胸腺

研究成果

[学会発表] AIRE遺伝子と自己免疫疾患と胸腺について

松本　満 2016

[学会発表] A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein.

Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima, and Mitsuru Matsumoto 2015

[学会発表] Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program.

Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka 2015

[学会発表] Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program.

Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto 2015

[学会発表] Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE.

Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano, and Mitsuru Matsumoto 2015

[学会発表] Role of Aire in the establishment of self-tolerance.

Mitsuru Matsumoto 2015

[雑誌論文] Switching on the Aire conditioner.

Mitsuru Matsumoto 2015

[雑誌論文] NIK in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells

Mouri, Y., Nishijima, H., Kawano, H., Hirota, F., Sakaguchi, N., Morimoto, J., Matsumoto, M. 2014

[学会発表] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program

Nishikawa, Y., Mouri, Y., Nishijima, H., Matsumoto, M. 2013

[学会発表] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

西嶋　仁、毛利安宏、西川裕美子、松本　満 2013

[学会発表] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program

Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y. 2013

[学会発表] Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage

Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H. 2013

[雑誌論文] TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall’s corpuscles in mice

Odaka, C., Hauri-Hohl, M., Takizawa, K., Nishikawa, Y., Yano, M., Matsumoto, M., Boyd, R., Hollander, G.A. 2013

[学会発表] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment

Nishijima, H., Morimoto, J., Kawano, H., Mouri, Y., Ikuta, K., Matsumoto, M. 0

[学会発表] 胸腺皮質上皮細胞への異所性発現による Aire の機能解析

西嶋　仁、生田宏一、松本　満 0

[学会発表] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor

Matsumoto, M., Nishijima, H. 0

[学会発表] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance

Nishijima, H., Morimoto, J., Mouri, Y., Nishikawa, Y., Ikuta, K., Matsumoto, M.

[学会発表] Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells

Kawano, H., Morimoto, J., Mouri, Y., Nishijima, H., Nishioka, Y., Matsumoto, M. 0

[学会発表] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program

Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H.

[学会発表] Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex

Nishijima, H., Morimoto, J., Mouri, Y., Kawano, H., Ikuta, K., Matsumoto, M. 0

[学会発表] Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of Aire-expressing cells

Kawano, H., Matsumoto, M. 0