研究成果

[学会発表] Pivotal role of TAK-1 in tumor growth and bone destruction in myeloma: therapeutic impact of TAK-1 inhibition.

umpei Teramachi, Masahiro Hiasa, Asuka Oda, Hirofumi Tenshin, Ryota Amachi, Takeshi Harada, Shingen Nakamura, Hirokazu Miki, Itsuro Endo, Tatsuji Haneji, Toshio Matsumoto and Masahiro Abe. 2015

[雑誌論文] Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH).

Dong B, Endo I, Ohnishi Y, Kondo T, Hasegawa T, Amizuka N, Kiyonari H, Shioi G, Abe M, Fukumoto S, Matsumoto T. 2015

[雑誌論文] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.

Hiasa M, Teramachi J, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M. 2015

[学会発表] Spaceflight Bone Atrophy-Problem Solved?

Adrian LeBlanc, Toshio Matsumoto, Jeffrey Jones, Jay Shapiro, Thomas Lang, Linda Shackelford, Scott M. Smith, Harlan Evans, Elisabeth Spector, Robert Ploutz-Snyder, Jean Sibonga, Joyce Keyak, Toshitaka Nakamura, Kenjiro Kohri, Hiroshi Ohshima, Gilbert Moralez. 2015

[学会発表] RAIL is not a proapoptotic but rather anti-apoptotic mediator for osteoclasts to stimulate their differentiation and survival.

Hirohfumi Tenshin, Jumpei Teramachi, Asuka Oda, Ryota Amachi, Masahiro Hiasa, Keiishiro Watanabe, Singen Nakamura, Hirokazu Miki, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto, Masahiro Abe. 2015

[雑誌論文] Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.

Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M. 2015

[雑誌論文] The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density.

ecknor CP, Recker RR, Benson CT, Robins DA, Chiang AY, Alam J, Hu L, Matsumoto T, Sowa H, Sloan JH, Konrad RJ, Mitlak BH, Sipos AA. 2015

[雑誌論文] A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density.

Recker RR, Benson CT, Matsumoto T, Bolognese MA, Robins DA, Alam J, Chiang AY, Hu L, Krege JH, Sowa H, Mitlak BH, Myers SL. 2015

[雑誌論文] The Effect of Discontinuing Treatment with Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women with Low Bone Mineral Density.

Recknor CP, Recker RR, Benson CT, Robins DA, Chiang AY, Alam J, Hu L, Matsumoto T, Sowa H, Sloan JH, Konrad RJ, Mitlak BH, Sipos AA 2015

[雑誌論文] Eldecalcitol reduces osteoporotic fractures by unique mechanisms.

Kondo S, Takano T, Ono Y, Saito H, Matsumoto T 2015

[雑誌論文] High serum parathyroid hormone and calcium are risk factors for hypertension in Japanese patients.

Yagi S, Aihara K, Kondo T, Endo I, Hotchi J, Ise T, Iwase T, Akaike M, Matsumoto T, Sata M 2014

[雑誌論文] Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release.

Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Sakamoto W, Yogo T, Ishimura K 2014

[雑誌論文] Defining and targeting myeloma stem cell-like cells.

Abe M, Harada T, Matsumoto T 2014

[雑誌論文] Fracture Risk Reduction with Denosumab in Japanese Postmenopausal Women and Men with Osteoporosis: Denosumab fracture Intervention RandomizEd placebo Controlled Trial (DIRECT).

Nakamura T, Matsumoto T, Sugimoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Sone T, Nakano T, Ito M, Matsui S, Yoneda T, Takami H, Watanabe K, Osakabe T, Shiraki M, Fukunaga M 2014

[雑誌論文] Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.

Hiasa M, Jumpei T, Oda A, Amachi R, Harada T, Nakamura S, Miki S, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M. 2014

[雑誌論文] Concise review: defining and targeting myeloma stem cell-like cells.

Abe M, Harada T, Matsumoto T 2014

[雑誌論文] Relationship Between The Effect Of Eldecalcitol And Serum 25(OH)D Level.

Takano T, Kondo S, Saito H, Matsumoto T 2014

[雑誌論文] Vitamin D analogs and bone: preclinical and clinical studies with eldecalctol.

Matsumoto-T, Takano T, Saito H, Takahashi F 2014

[雑誌論文] Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors.

Harada T, Ozaki S, Oda A, Tsuji D, Ikegame A, Iwasa M, Udaka K, Fujii S, Nakamura S, Miki H, Kagawa K, Kuroda Y, Kawai S, Itoh K, Yamada-Okabe H, Matsumoto T, Abe M. 2013

[雑誌論文] Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib.

Nakamura S, Miki H, Kido S, Nakano A, Hiasa M, Oda A, Amou H, Watanabe K, Harada T, Fujii S, Takeuchi K, Kagawa K, Ozaki S, Matsumoto T, Abe M. 2013

[雑誌論文] Association of Th1 and Th2 cytokines with transient inflammatory reaction during lenalidomide plus dexamethasone therapy in multiple myeloma.

Harada T, Ozaki S, Oda A, Fujii S, Nakamura S, Miki H, Kagawa K, Takeuchi K, Matsumoto T, Abe M. 2013

[雑誌論文] Parathyroid hormone (1-34) counteracts the suppression of interleukin-11 expression by glucocorticoid in murine osteoblasts: a possible mechanism for stimulating osteoblast differentiation against glucocorticoid excess.

Kuriwaka-Kido R, Kido S, Miyatani Y, Ito Y, Kondo T, Omatsu T, Dong B, Endo I, Miyamoto K, Matsumoto T 2013

[学会発表] Effect of a calcilytic compound in autosomal dominant hypocalcemia model mice.

Bingzi Dong, Itsuro Endo, Takeshi Kondo, Yukiyo Ohnishi, Masahiro Abe, Seiji Fukumoto, Tomoka Hasegawa, Norio Amizuka, Shin-ichi Aizawa, Toshio Matsumoto 0

[学会発表] 骨髄腫骨病変と腫瘍免疫．シンポジウム5 骨免疫と炎症性疾患．

安倍正博

[学会発表] Potent induction of bone formation in myeloma bone lesions by the cathepsin K inhibitor KK1-300-01 in combination with the proteasome inhibitor bortezomib.

Keiichiro Watanabe, Masahiro Abe, Hiroshi Mori, Ryota Amachi, Masahiro Hiasa, Takeshi Harada, Shiro Fujii, Shingen Nakamura, Hirokazu Miki, Kumiko Kagawa, Itsuro Endo, Eiji Tanaka, Toshio Matsumoto.

[学会発表] Interleukin-11 is an important factor for mechanical stress-induced osteoblast differentiation and bone formation.

Takeshi Kondo, Bingzi Dong, Takashi Omatsu, Yukiyo Ohnishi, Itsuro Endo, Masahiro Abe, Shinichi Aizawa, Hiroshi Sakaue, Toshio Matsumoto 0

[学会発表] Overview of the pathophysiology of MBD and acquired genetic events:Bench work for the targeted therapy to the microenvironment of MBD. Session: Myeloma bone disease.

M Abe.

[学会発表] Bisphosphonate ISS Flight Experiment.

LeBlanc A, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Evans H, Spector E, Ploutz-Snyder R, Sibonga J, Keyak J, Nakamura T, Kohri K, Ohshima H, Moralez G 0