トップ研究者を探す内皮/上皮病態連関とROS/NO不均衡を基軸とした腎臓病の病態理解と治療法開発

内皮/上皮病態連関とROS/NO不均衡を基軸とした腎臓病の病態理解と治療法開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-24K02468
研究種目 基盤研究(B)
研究分野
研究機関 川崎医科大学
代表研究者 柏原 直樹
研究分担者 長洲 一
研究分担者 岸 誠司
研究分担者 城所 研吾
研究分担者 角谷 裕之
研究期間 開始年月日 2024/4/1
研究期間 終了年度 2026
研究ステータス 交付 (2024/4/1)
配分額(合計) 18,590,000 (直接経費 :14,300,000、間接経費 :4,290,000)
配分額(履歴) 2026年度:5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2025年度:6,500,000 (直接経費 :5,000,000、間接経費 :1,500,000)
2024年度:6,890,000 (直接経費 :5,300,000、間接経費 :1,590,000)
キーワード 活性酸素種
NO
ポドサイト
TRPC
PKG

研究成果

[雑誌論文] ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice.

Kajimoto E, Nagasu H, Takasu M, Kishi S, Wada M, Tatsugawa R, Hirano A, Iwakura T, Umeno R, Wada Y, Itano S, Kadoya H, Kidokoro K, Sasaki T, Kashihara N. 2024

[雑誌論文] Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure.

Hirano A, Kadoya H, Takasu M, Iwakura T, Kajimoto E, Tatsugawa R, Matsuura T, Kurumatani H, Yamamoto T, Kidokoro K, Kishi S, Nagasu H, Sasaki T, Kashihara N. 2024

[学会発表] Impact of the Nonsteroidal Mineralocorticoid Receptor Blocker Esaxerenone on Glomerular Hemodynamics in Diabetic Kidney Disease

Rie Tatsugawa, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara. 2024

[学会発表] Elucidation of the Renoprotective Effects of SGLT2 Inhibitors in Nondiabetic CKD

Akira Hirano, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara. 2024

[学会発表] Transient DNA Damage in Proximal Tubules Accelerates Kidney Aging

Masanobu Takasu, Seiji Kishi, Yuhei Kirita, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara, Motoshi Hayano. 2024

[学会発表] Impaired Glomerular Epithelial Cell sGC Activation Promotes Glomer- Significance of Glomerular Epithelial Cell sGC Activation via eNOS-NO Pathway in Diabetic Kidney Disease

Eriko Kajimoto, Masanobu Takasu, Rie Tatsugawa, Akira Hirano, Tsukasa Iwakura, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Hiroyuki Kadoya, Naoki Kashihara 2024

[学会発表] 糖尿病関連腎臓病におけるエサキセレノンによる腎微小循環動態の改善効果

立川 理絵、城所研吾、和田佳久、長洲 一、 岸 誠司、佐々木環、柏原直樹 2024

[学会発表] Investigating the Effects of Low-Level and Transient DNA Damage on Kidney Health in a Novel Mouse Model of Aging

Masanobu Takasu, Seiji Kishi, Yuhei Kirita, Hajime Nagasu, Kengo Kidokoro, Tamaki Sasaki, Motoshi Hayano, Naoki Kashihara 2024

[学会発表] Investigating the effects of low-level and transient DNA damage on kidney health in a novel mouse model of aging

Masanobu Takasu,Seiji Kishi,Yuhei Kirita,Hajime Nagasu,Kengo Kidokoro,Tamaki Sasaki,Motoshi Hayano,Naoki Kashihara 2024

[学会発表] SGLT2 Inhibition suppresses residual nephron glomerular hyperfiltration in Non-Diabetic Chronic Kidney Disease

Akira Hirano, Kengo Kidokoro, Masanobu Takasu, Rie Tatsugawa, Eriko Kajimoto, Tsukasa Iwakura, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara 2024

[学会発表] Elucidation of glomerular hemodynamic changes by mineralocorticoid receptor blocker esaxerenone in diabetic kidney disease

Rie Tatsugawa, Kengo Kidokoro, Masanobu Takasu, Akira Hirano, Tukasa Iwakura, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara 2024

[学会発表] 新規老化モデル動物を用いた後天的DNAストレスが腎に与える影響の解明

高須将伸、岸 誠司、桐田 雄平、長洲 一、佐々木 環、早野 元詞、柏原 直樹 2024

[学会発表] 糖尿病関連腎臓病におけるeNOS-NO経路を介した糸球体上皮細胞sGC活性化の意義

梶本恵莉子、和田将史、髙須将伸、岸誠司、長洲一、佐々木環、柏原直樹 2024

[学会発表] Elucidation of the Molecular Mechanism of Albuminuria Improvement by Non-Steroidal Mineralocorticoid Receptor (MR) Antagonists Finerenone.

Tsukasa Iwakura, Kengo Kidokoro, Eriko Kajimoto, Masanobu Takasu, Akira Hirano, Rie Tatsugawa, Hiroyuki Kadoya, Seiji Kishi, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara 2024

[雑誌論文] Treatment of chronic kidney disease in older populations.

Kishi S, Kadoya H, Kashihara N. 2024

[学会発表] Podocyte damage observed in neuronal intranuclear inclusion body disease

Natsumi Inoue, Fumiaki Sanuki, Yu Yamanouchi, Seiji Itano, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Tatsuo Kohriyama, Jun Sone, Tamaki Sasaki, Naoki Kashihara 2024

[学会発表] 糖尿病関連腎臓病におけるエサキセレノンによる腎糸球体血行動態変化の解析

立川理絵、城所研吾、高須将伸、平野憲、岩倉主、角谷裕之、 岸 誠司、長洲 一、佐々木環、柏原直樹 2024

[学会発表] Endothelial Dysfunction Fuels Progression from Acute to Chronic Kidney Disease through Macrophage-Mediated β-Catenin Activation

Masanobu Takasu, Seiji Kishi, Hajime Nagasu, Rie Tatsugawa, Eriko Kajimoto, Akira Hirano, Tsukasa Iwakura, Hiroyuki Kadoya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara 2024