トップ研究者を探すBDNFから解明する新生児期ストレスの脳への影響

BDNFから解明する新生児期ストレスの脳への影響

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-24791111
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
胎児・新生児医学
研究機関 香川大学
代表研究者 鈴木 辰吾
研究期間 開始年月日 2012/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額(履歴) 2013年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2012年度:2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
キーワード BDNF
コレステロール
母子分離
パルミトイル酸
母子分離モデル
パルミトレイン酸
神経細胞
発達
シナプス

研究成果

[雑誌論文] Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system : a novel insight into understanding the initial processes of alcohol addiction

Miki T, Kusaka T, Yokoyama T, Ohta KI, Suzuki S, Warita K, Jamal M, Wang ZY, Ueki M, Liu JQ, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y 2014

[雑誌論文] Early postnatal repeated maternal deprivation causes a transient increase in OMpg and BDNF in rat cerebellum suggesting precocious myelination

Miki T, Yokoyama T, Kusaka T, Suzuki S, Ohta KI, Warita K, Wang ZY, Ueki M, Sumitani K, Bellinger FP, Tamai M, Liu JQ, Yakura T, Takeuchi Y 2014

[雑誌論文] Prolonged maternal separation disturbs the serotonergic system during early brain development

Ohta KI, Miki T, Warita K, Suzuki S, Kusaka T, Yakura T, Liu JQ, Tamai M, Takeuchi Y 2013

[学会発表] ニューロンによるコレステロール合成とシナプス発達

鈴木辰吾 2013

[雑誌論文] In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment

Warita K, Mitsuhashi T, Ohta KI, Suzuki S, Hoshi N, Miki T, Takeuchi Y 2013

[雑誌論文] Early postnatal maternal separation causes alterations in the expression of β3-adrenergic receptor in rat adipose tissue suggesting long-term influence on obesity

Miki T, Liu JQ, Ohta K, Suzuki S, Kusaka T, Warita K, Yokoyama T, Jamal M, Ueki M, Yakura T, Tamai M, Sumitani K, Hosomi N, Takeuchi Y 2013

[学会発表] 「BDNFによるニューロンのコレステロール合成誘導とプレシナプス蛋白質のラフトへの移動

鈴木辰吾 2013

[雑誌論文] Gene expression of epigenetic regulatory factors related to primary silencing mechanism is less susceptible to lower doses of bisphenol A in embryonic hypothalamic cells

Warita K, Mitsuhashi T, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y 2013

[雑誌論文] Immunohistochemical analysis of steroidogenic acute regulatory protein (StAR) and StAR-binding protein (SBP) expressions in the testes of mice during fetal development

Warita K, Mitsuhashi T, Fukui S, Ohta K, Suzuki S, Miki T, Takeuchi Y, Yokoyama T, Kitagawa H, Sugawara T, Hoshi N 2013

[学会発表] 神経回路の新しい可視化法の開発

鈴木辰吾 2013

[雑誌論文] In vitro evaluation of gene expression changes for gonadotropin-releasing hormone 1, brain-derived neurotrophic factor, and neurotrophic tyrosine kinase, receptor, type 2, in response to bisphenol A treatment.

Warita K, Mitsuhashi T, Ohta KI, Suzuki S, Hoshi N, Miki T, Takeuchi Y 2013

[雑誌論文] Morphological Evidence of an Altered Process of Synaptic Transcytosis in Adult Rats Exposed to Ethanol

Takeuchi Y, Miki T, Liu JQ, Ohta KI, Warita K, Matsumoto Y, Suzuki S, Tamai M, Ameno K, Bedi KS, Yakura T 2012

[学会発表] BDNF-regulared cholesterol metabolism for synapse development

Shingo SUZUKI 2012

[雑誌論文] Microarray and gene ontology analyses reveal downregulation of DNA repair and apoptotic pathways in diethylstilbestrol-exposed testicular Leydig cells

Warita K, Mitsuhashi T, Tabuchi Y, Ohta K, Suzuki S, Hoshi N, Miki T, Takeuchi Y 2012

[学会発表] BDNF-regulared cholesterol metabolism for synapse development

Suzuki S 2012

[雑誌論文] BDNF-dependent accumulation of palmitoleic acid in CNS neurons

Suzuki S, Hongli Q, Okada A, Kasama T, Ohta K, Warita K, Tanaka K, Miki T and Takeuchi Y 2012

[雑誌論文] Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats

Lee KY, Miki T, Yokoyama T, Ueki M, Warita K, Suzuki S, Ohta KI, Wang ZY, Jamal M, Yakura T, Liu JQ, Hosomi N, Takeuchi Y 2012

[雑誌論文] Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks

Suzuki K, Maekawa F, Suzuki S, Nakamori T, Sugiyama H, Kanamatsu T, Tanaka K, Ohki-Hamazaki H 2012