トップ研究者を探す増殖因子と細胞内シグナル制御による糖尿病網膜症の病的血管の再生治療

増殖因子と細胞内シグナル制御による糖尿病網膜症の病的血管の再生治療

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-24592631
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
眼科学
研究機関 長崎大学
代表研究者 鈴間 潔
研究分担者 築城 英子
研究分担者 藤川 亜月茶
研究分担者 松本 牧子
研究分担者 北岡 隆
研究期間 開始年月日 2012/4/1
研究期間 終了年度 2015
研究ステータス 完了 (2015/4/1)
配分額(合計) 5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
配分額(履歴) 2014年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2013年度:1,690,000 (直接経費 :1,300,000、間接経費 :390,000)
2012年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
キーワード VEGF
糖尿病網膜症
エリスロポエチン
コハク酸
インクレチン
exendin4
血管透過性
毛様体
神経節細胞
iPS細胞
血管再生

研究成果

[雑誌論文] 緑内障インプラントの術後2年成績について

藤川亜月茶,梶山彩乃,木下明夫,鈴間 潔,北岡 隆 2016

[雑誌論文] Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells.

Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M 2016

[学会発表] Comparison of retinal and choroidal blood flow changes after treatment with ranibizumab or aflibercept in exudative age-related macular degeneration.

Yoneda A, Suzuma K, Maekawa Y, Tsuiki E, Kitaoka T 2015

[学会発表] The visual outcome and prognostic factors in open globe ocular injuries.

Fujikawa A, Kinoshita H, Matsumoto M, Tsuiki E, Suzuma K, Kitaoka T 2015

[学会発表] NEURITE OUTGROWTH FROM RETINAL GANGLION CELLS IN SELF-ORGANIZING MOUSE AND HUMAN RETINAL TISSUES DIFFERENTIATED FROM EMBRYONIC STEM CELLS.

Maekawa Y, Onishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kitaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi M 2015

[学会発表] Retinal blood flow levels after intravitreal ranibizumab for diabetic macular edema.

Matsumoto M, Suzuma K, Tsuiki E, Fujikawa A, Kitaoka T 2015

[雑誌論文] Influence of different additives and their concentrations on corneal toxicity and antimicrobial effect of benzalkonium chloride.

Onizuka N, Uematsu M, Kusano M, Sasaki H, Suzuma K, Kitaoka T 2014

[雑誌論文] Cyclic stretch and hypertension increase retinal succinate: potential mechanisms for exacerbation of ocular neovascularization by mechanical stress.

Kinoshita H, Suzuma K, Maki T, Maekawa Y, Matsumoto M, Kusano M, Uematsu M, Kitaoka T: 2014

[雑誌論文] Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions.

Kumagami T, Wakiyama H, Kusano M, Kajiyama A, Miura Y, Uematsu M, Yoneda A, Kurihara J, Suzuma K, Kitaoka T 2014

[雑誌論文] Retinal blood flow levels measured by laser speckle flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.

Matsumoto M, Suzuma K, Fukazawa Y, Yamada Y, Tsuiki E, Fujikawa A, Kitaoka T 2014

[雑誌論文] Imaging of laser-photocoagulated diabetic Enhanced Depth Imaging Imaging of laser-photocoagulated diabetic microaneurysm with spectral domain optical coherence tomography.

Yamada Y, Suzuma K, Fujikawa A, Kumagami T, Kitaoka T 2013

[雑誌論文] Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion.

Tsuiki E, Suzuma K, Ueki R, Maekawa Y, Kitaoka T 2013

[雑誌論文] Systemic factors influence the prognosis of diabetic Ocular gene delivery systems using ternary complexes of plasmid DNA, polyethylenimine, and anionic polymers.

Kurosaki T, Uematsu M, Shimoda K, Suzuma K, Nakai M, Nakamura T, Kitahara T, Kitaoka T, Sasaki H 2013

[雑誌論文] Systemic factors influence the prognosis of diabetic macular edema after pars plana vitrectomy with internal limiting membrane peeling.

Yamada Y, Suzuma K, Kumagami T, Fujikawa A, Kitaoka T 2013

[雑誌論文] Systemic factors influence the prognosis of diabetic macular edema after pars plana vitrectomy with internal limiting membrane peeling.

Yamada Y, Suzuma K, Ryu M, Tsuiki E, Fujikawa A, Kitaoka T 2013

[学会発表] Cyclic Stretch And Hypertension Increase Retinal Succinate And Fumarate: Potential Mechanisms For Exacerbation Of Ocular Neovascularization By Mechanical Stress.

Kinoshita H, Suzuma K, Maki T, Matsumoto M, Kusano M, Uematsu M, Kitaoka T 2012

[雑誌論文] Succinate increases in the vitreous fluid of patients with active proliferative diabetic retinopathy

Matsumoto M, Suzuma K, Maki T, Kinoshita H, Tsuiki E, Fujikawa A, Kitaoka T 2012

[学会発表] Retinal Blood Flow in Patients With Diabetic Retinopathy Treated With Panretinal Photocoagulation.

Onizuka N, Suzuma K, Yamada Y, Uematsu M, Kitaoka T 2012

[雑誌論文] Spontaneous dislocation of in-the-bag intraocular lens primarily occurred in cases with prior vitrectomy

Matsumoto M, Yamada K, Uematsu M, Fujikawa A, Tsuiki E, Kumagami T, Suzuma K, Kitaoka T 2012

[学会発表] Retinal Blood Flow Levels Measured by Laser Speckle Flowgraphy Before and After Vitrectomy for Diabetic Macular Edema.

Matsumoto M, Suzuma K, Yamada Y, Liu M, Tsuiki E, Fujikawa A, Kitaoka T 2012

[学会発表] Retinal and choroidal blood flow changes after switching therapy from ranibizumab to aflibercept in exudative age-related macular degeneration.

Yoneda A, Suzuma K, Maekawa Y, Tsuiki E, Wakiyama H, Kitaoka T 0

[学会発表] Generation of ciliary epithelium from mouse ES and iPS cells.

Kinoshita H, Suzuma K, Kaneko J, Mandai M, Kitaoka T, Takahashi M 0

[学会発表] Retinal blood flow levels measured by Laser Speckle Flowgraphy significantly increased after vitrectomy for diabetic macular edema.

Matsumoto M, Suzuma K, Tsuiki E, Fujikawa A, Kitaoka T 0

[学会発表] Correlation of retina circulation and blood pressure before and after panretinal photocoagulation for diabetic retinopathy.

Onizuka N, Uematsu M, Suzuma K, Kitaoka T: 0

[学会発表] Benzalkonium chloride of alkyl chain length C12 is safer for corneal epithelium.

Uematsu M, Onizuka N, Ueki R, Suzuma K, Kitaoka T 0