研究成果

[学会発表] 転写因子IRF8によるC/EBPαの機能阻害が単核貪食細胞前駆細胞において好中球分化能の喪失をもたらす．

黒滝大翼, 山本道雄, 西山 晃, 宇野和宏, 藩 龍馬, 市野素英, 佐々木 悠, 松永智子, 吉成正裕, 梁 明秀, 中澤正年, Keiko Ozato, 田村智彦 2015

[学会発表] The transcription factor IRF8 is essential for basophil development.

Sasaki H, Kurotaki D, Osato N, Sato H, Sasaki I, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC III, Ozato K, Tamura T 2014

[学会発表] BCR-ABL inactivates the distal enhancer of the Irf8 gene and represses its expression.

Tamura T, Miyashita K, Koizumi S, Yamamoto M, Kurotaki D, Nakabayashi J, Ishigatsubo Y, Nishiyama A 2014

[学会発表] 単球分化に必須のIRF8-KLF4転写因子カスケードの発見.

黒滝大翼, 大里直樹, 西山 晃, 山本道雄, 田村智彦 2014

[学会発表] Role of the transcription factor IRF8 in the developmental pathways of mast cells.

Sasaki H, Kurotaki D, Tamura T 2014

[学会発表] ゲノム規模解析による単球分化に重要なIRF8-KLF4転写因子カスケードの発見

黒滝大翼, 他 2012

[学会発表] Genome-wide analyses revealed the IRF8-KLF4 transcription factor cascade during monocytedifferentiation

Kurotaki D., et al. 2012

[学会発表] The IRF8-KLF4 transcription factor cascade critically regulates the development of inflammatory monocytes

Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.

[学会発表] The transcription factor IRF8 is required for basophil development

Sasaki H., Kurotaki D., Osato N., Sasaki I., Kaneda C., Nishiyama A., Kaisho T., Morse H.C. III., Ozato K., Tamura T.

[学会発表] The transcription factor IRF8 is required for the development of basophils

Sasaki H., Kurotaki D., Sato H., Morse H.C. III, Ozato K., Tamura T.

[学会発表] 転写因子IRF8は単球-樹状細胞前駆細胞においてC/EBPαの機能を阻害し、好中球分化能の喪失をもたらす

黒滝大翼，山本道雄，宇野和宏，西山 晃，中林 潤，中澤正年，Herbert C. Morse III，Keiko Ozato，田村智彦

[学会発表] M期での転写メモリーとストレス応答におけるBRD4の役割

Nishiyama A, Kurotaki D, Tamura T.

[学会発表] IRF8 Inhibits the Activity of C/EBPα to Restrain Monocyte-Dendritic Cell Progenitors from Differentiating into Neutrophils

Yamamoto M., Kurotaki D., Nishiyama A., Uno K., Ichino M., Nakazawa M., Ozato K., Tamura T

[学会発表] IRF8 restrains monocyte-dendritic cell progenitors from differentiating into neutrophils by inhibiting C/EBPα activity

Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Sasaki H., Ozato K., Tamura T.

[学会発表] The IRF8-KLF4 transcription factor cascade is essential for the development of monocytes

Kurotaki D., Osato N., Nishiyama A., Yamamoto M., Ban T., Sato H., Nakabayashi J., Umehara M., Nakazawa M., Miyake N., Matsumoto N., Ozato K., Tamura T.

[学会発表] The transcription factor IRF8 is required for the development of basophils

Sasaki H., Kurotaki D., Sato H., Morse HC III., Ozato K., Tamura T.

[学会発表] IRF8 inhibits the activity of C/EBPs to restrain neutrophil development in monocyte-DC progenitors.

Kurotaki D., Yamamoto M., Uno K., Nishiyama A., Nakabayashi J., Morse H.C. 3rd., Ozato K., Tamura T.

[学会発表] The transcription factor IRF8 is a key transcription factor for basophil development

Kurotaki D., Sasaki H., Osato N., Sasaki I., Kaneda C., Sato H., Nishiyama A., Kaisho T., Aburatani H., Morse H.C. 3rd., Ozato K., Tamura T.

[学会発表] IRF8 inhibits the activity of C/EBP to restrain the neutrophil differentiation program in monocyte-dendritic cell progenitors

Kurotaki D., Yamamoto M., Nishiyama A., Uno K., Ichino M., Sasaki H., Ban T., Yoshinari M., Nakazawa M., Ozato K., Tamura T.

[学会発表] 単核貪食細胞群の分化機構に関する研究．

西山晃，黒滝大翼，中林潤，田村智彦 0

[学会発表] dynamic and long-range chromatin control of Klf4 transcription by IRF8 in monocyte differentiation

Nishiyama A., Kurotaki D., Tamura T.

[学会発表] The transcription factor IRF8 overrides BCR-ABL to rescue dendritic cell development in chronic myeloid leukemia.

Watanabe T., Hotta C., Koizumi S., Miyashita K., Nakabayashi J., Kurotaki D., Sato R. G., Yamamoto M., Nishiyama A., Aihara M., Ishigatsubo Y., Tamura T.

[学会発表] 単球分化において転写因子IRF8がKlf4プロモーターと遠位エンハンサーの長距離間の相互活性化を誘導する

西山 晃，黒滝大翼，田村智彦