白血病幹細胞根絶を目指した人工ＣＴＬによる新規免疫遺伝子治療の開発研究

トップ›研究者を探す›白血病幹細胞根絶を目指した人工ＣＴＬによる新規免疫遺伝子治療の開発研究

白血病幹細胞根絶を目指した人工ＣＴＬによる新規免疫遺伝子治療の開発研究

代表研究者	安川正貴
研究課題番号	KAKENHI-PROJECT-24390245
研究種目	基盤研究(B)
研究分野	生物系医歯薬学内科系臨床医学血液内科学
研究機関	愛媛大学
連携研究者	藤原弘
研究期間開始年月日	2012/4/1
研究期間終了年度	2014
研究ステータス	完了 (2014/4/1)
配分額（合計）	17,810,000 (直接経費 :13,700,000、間接経費 :4,110,000)
配分額（履歴）	2014年度：5,720,000 (直接経費 :4,400,000、間接経費 :1,320,000) 2013年度：5,590,000 (直接経費 :4,300,000、間接経費 :1,290,000) 2012年度：6,500,000 (直接経費 :5,000,000、間接経費 :1,500,000)
キーワード	白血病がん免疫療法細胞傷害性T細胞 T細胞レセプター遺伝子治療細胞障害性Ｔ細胞 CAR-T細胞 WT1 抗体療法白血病幹細胞Ｔ細胞レセプターヒト化マウス CD16 hTERT 免疫療法

研究成果

[雑誌論文] Antileukemia multifunctionality of CD4+ T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer

Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Narita M, Okamoto S, Mineno J, Kuzushima K, Shiku H, and Yasukawa M 2015

[学会発表] Activation Status of Integrin αIIbβ3 in Essential Thrombocythemia with Calreticulin Mutation

Jun Yamanouchi , Takaaki Hato, Etsuko Matsubara, Taichi Azuma, Hideyuki Nakanishi, Hiroshi Fujiwara, Yoshihiro Yakushijin, and Masaki Yasukawa 2014

[学会発表] Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto , Hiroshi Fujiwara, Hiroki Tanaka, Fumihiro Ochi , Hiroaki Asai, Sachiko Okamoto, JunichiMineno , Kiyotaka Kuzushima, Hiroshi Shiku, John Barrett, and Masaki Yasukawa 2014

[雑誌論文] Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression.

Rowan AG, Suemori K, Fujiwara H, Yasukawa M, Tanaka Y, Taylor GP, Bangham C. 2014

[雑誌論文] Abnormal behaviors and developmental disorder of hippocampus in zinc finger protein 521 (ZFP521) mutant mice.

Ohkubo N, Matsubara E, Yamanouchi J, Akazawa R, Aoto M, Suzuki Y, Sakai I, Abe T, Kiyonari H, Matsuda S, Yasukawa M, Mitsuda N. 2014

[雑誌論文] Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.

Matsumoto T, Yasukawa M, et al. 2013

[雑誌論文] Clinical characteristics and outcomes of Chédiak-Higashi syndrome: a nationwide survey of Japan.

Nagai K, Yasukawa M, et al. 2013

[学会発表] Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Asai H, Yasukawa M, et al. 2012

[学会発表] Human Telomerase Reverse Transcriptase-specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Fujiwara H, Yasukawa M, et al. 2012

[雑誌論文] The role of activation-induced cytidine deaminase (AID/AICDA) in the progression of follicular lymphoma

Shikata H, Yasukawa M, et al. 2012

[学会発表] Redirected CD4+ T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Miyazaki Y, Yasukawa M, et al. 2012