研究成果

[学会発表] TSODマウスの有する新たな可能性を探る

常山幸一、渡邊俊介、高橋徹行、小川博久、上原久典、西田健志、八田秀樹、馬場逸人、井村穣二 2015

[雑誌論文] Emerging of IL-33 in inflammation and immune regulation.

Ikutani M, tsuneyama K, Nakae S, Takatsu K. 2015

[学会発表] 見えないものを“見る”技術～メタボリックシンドロームからイタイイタイ病まで～

常山幸一 2015

[雑誌論文] Immunologic potential of CTLA-4 Ig in murine autoimmune cholangitis.

Tanaka H, Yang GX, Tomiyama T, Tsuneyama K, Zhang W, Leung PS, Coppel RL, Joh T, Nadler SG, Ansari AA, Bowlus C, Gershwin ME. 2015

[雑誌論文] Effect of keishibukuryogan on genetic and dietary obesity models.

Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y. 2015

[雑誌論文] Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.

Iida A, Sasaki E, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. 2015

[雑誌論文] An SHR/NDmcr-cp Rat Model of Non-alcoholic steatohepatitis with advanced fibrosis induced by a High-fat, High-cholesterol Diet.

Ichimura M, Hatanaka M, Tsuneyama K, Kato S, Omagari K. 2015

[雑誌論文] Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα(-/-) mice.

Yao Y, Yang W, Yang YQ, Ma HD, Lu FT, Li L, Tao YY, Tsuneyama K, Zhang W, Friedman S, Gershwin ME, Lian ZX. 2014

[雑誌論文] Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate.

Kurano M, Hara M, Tsuneyama K, Sakoda H, Shimizu T, Tsukamoto K, Ikeda H, Yatomi Y. 2014

[雑誌論文] Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells.

anaka H, Zhang W, Yang GX, Ando Y, Tomiyama T, Tsuneyama K, Leung P, Coppel RL, Ansari AA, Lian ZX, Ridgway WM, Joh T, Gershwin ME. 2014

[雑誌論文] Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease.

Baba H, Tsuneyama K, Kumada T, Aoshima K, Imura J. 2014

[雑誌論文] A simple and rapid decalcification procedure of skeletal tissues for pathology using an ultrasonic cleaner with D-mannitol and formic acid.

Hatta H, Tsuneyama K, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nishida T, Nakanishi Y, Imura J. 2014

[雑誌論文] Neonatal streptozotocin treatment causes type 1 diabetes and subsequent hepatocellular carcinoma in DIAR mice fed a normal diet.

Baba H, Tsuneyama K, Nishida T, Hatta H, Nakajima T, Nomoto K, Hayashi S, Miwa S, Nakanishi Y, Hokao R, Imura J. 2014

[雑誌論文] Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung.

Imura J, Abe K, Uchida Y, Shibata M, Tsunematsu K, Sathoh M, Miwa S, Nakajima T, Nomoto K, Hayashi S, Tsuneyama K. 2014

[雑誌論文] Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: Implication for cancer therapy.

Cui ZG, Piao JL, Kondo T, Ogawa R, Tsuneyama K, Zhao QL, Feril LB Jr, Inadera H. 2014

[雑誌論文] Social Isolation Stress-Induced Fear Memory Deficit is Mediated by Down-Regulated Neuro-Signaling System and Egr-1 Expression in the Brain.

Okada R, Matsumoto K, Tsushima R, Fujiwara H, Tsuneyama K. 2014

[雑誌論文] Animal models of primary biliary cirrhosis.

Wang J, Yang GX, Tsuneyama K, Gershwin ME, Ridgway WM, Leung PS. Animal models of primary biliary cirrhosis. 2014

[雑誌論文] Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis.

Kikuchi K, Tsuneyama K, Yamada H, Kajiyama Y, Matsumoto K, Tsunashima H, Yamashita R, Takai A, Negishi M, Hara M, Moritoki Y, Miyakawa H. 2014

[雑誌論文] Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Rα deleted mice.

Yang W, Yao Y, Yang YQ, Lu FT, Li L, Wang YH, Nakajima T, Tsuneyama K, Ridgway WM, Gershwin ME, Lian ZX. 2014

[雑誌論文] Clinicopathological analysis of CD8-positive lymphocytes in the tumor parenchyma and stroma of hepatocellular carcinoma.

An JL, Ji QH, An JJ, Masuda S, Tsuneyama K. 2014

[雑誌論文] Malignant transformation of hyperplastic gastric polyps: An immunohistochemical and pathological study of the changes of neoplastic phenotype.

Imura J, Hayashi S, Ichikawa K, Miwa S, Nakajima T, Nomoto K, Tsuneyama K, Nogami T, Saitoh H, Fujimori T. 2014

[学会発表] DIAR-MSGマウス：標準食飼育で肥満・糖尿病を経て大滴性脂肪性肝炎～肝細胞癌に至る新規モデル動物の開発

常山幸一、西田健志、野本一博、林伸一、三輪重治、中島隆彦、中西ゆう子、八田秀樹、井村穣二 2014

[雑誌論文] Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy.

Cui ZG, Piao JL, Kondo T, Ogawa R, Tsuneyama K, Zhao QL, Feril LB Jr, Inadera H. 2014

[雑誌論文] Neonatal MSG Treatment Causes Obesity, Diabetes, and Macrovesicular Steatohepatitis with Liver Nodules in DIAR Mice

Tsuneyama K, Nishida T, baba H, Taira S, Fujimoto m, Nomoto K, Hayashi S, Miwa S, Nakajima T, Sutoh M, Oda M, Hokao R, Imura J. 2014

[雑誌論文] IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: Implications for therapy.

Yang CY, Ma X, Tsuneyama K, Huang S, Takahashi T, Chalasani NP, Bowlus CL, Yang GX, Leung PS, Ansari AA, Wu L, Coppel RL, Gershwin ME. 2014

[雑誌論文] Escherichia coli infection induces autoimmune cholangitis and anti-mitochondrial antibodies in non-obese diabetic (NOD).B6 (Idd10/Idd18) mice.

Wang JJ, Yang GX, Zhang WC, Lu L, Tsuneyama K, Kronenberg M, Véla JL, Lopez-Hoyos M, He XS, Ridgway WM, Leung PS, Gershwin ME 2014

[雑誌論文] Involvement of oxidative stress and immune- and inflammation-related factors in azathioprine-induced liver injury.

Matsuo K, Sasaki E, Higuchi S, Takai S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. 2014

[雑誌論文] A Dietary Restriction Influences the Progression But Not the Initiation of MSG-Induced Nonalcoholic Steatohepatitis.

ujimoto M, Tsuneyama K, Nakanishi Y, Salunga TL, Nomoto K, Sasaki Y, Iizuka S, Nagata M, Suzuki W, Shimada T, Aburada M, Shimada Y, Gershwin ME, Selmi C. 2014

[雑誌論文] Neonatal monosodium glutamate treatment causes obesity, diabetes, and macrovesicular steatohepatitis with liver nodules in DIAR mice.

Tsuneyama K, Nishida T, Baba H, Taira S, Fujimoto M, Nomoto K, Hayashi S, Miwa S, Nakajima T, Sutoh M, Oda E, Hokao R, Imura J. 2014

[雑誌論文] Reversible phospho-Smad3 signalling between tumour suppression and fibrocarcinogenesis in chronic hepatitis B infection.

10: Deng YR, Yoshida K, Jin QL, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu JQ, Matsuzaki K, Lian ZX. 2014

[雑誌論文] Social isolation stress-induced fear memory deficit is mediated by down-regulated neuro-signaling system and Egr-1 expression in the brain.

Okada R, Matsumoto K, Tsushima R, Fujiwara H, Tsuneyama K. 2014

[雑誌論文] CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K. 2014

[雑誌論文] Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury.

Sasaki E, Iwamura A, Tsuneyama K, Fukami T, Nakajima M, Kume T, Yokoi T. 2014

[雑誌論文] Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice.

Takai S, Higuchi S, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. 2014

[雑誌論文] Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference.

Sun CP, Wu TH, Chen CC, Wu PY, Shih YM, Tsuneyama K, Tao MH. 2013

[雑誌論文] Overexpression of enhancer of zeste homolog 2 and MUCl may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.

Sasaki M, Matsubara T, Yoneda N, Nomoto K, Tsuneyama K, et al. 2013

[学会発表] Specific hemosiderin deposition in the spleen of TSOD mice. A unique spontaneous model showing obesity, diabetes, hyperlipidemia and steatohepatitis.

Nishida T, Tsuneyama K, et al. 2013

[学会発表] Autoimmune Features with Biliary Damages Frequently Overlapped in Old-aged Female Patients of Non-alcoholic Steatohepatitis.

5) Tsuneyama K, Baba H, Nomoto K, Nishida T, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Imura J. 2013

[雑誌論文] Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis.

Tanaka H, Yang GX, Iwakoshi N, Knechtle SJ, Kawata K, Tsuneyama K, Leung P, Coppel RL, Ansari AA, Joh T, Bowlus C, Gershwin ME. 2013

[学会発表] 新生児期MSG処置DIARマウスは標準食で肥満，糖尿病，及び大滴性脂肪滴を伴うNASHを発症する

18) 常山幸一，西田健志，野本一博，林伸一，三輪重治，中嶋隆彦，中西ゆう子，八田秀樹，井村穣二． 2013

[雑誌論文] Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice.

Tsuda M, Zhang W, Yang GX, Tsuneyama K, e tal. 2013

[雑誌論文] Gershwin ME. Clonality, activated antigen specific CD8(+)T cells and development of autoimmune cholangitis in dnTGFβRII mice.

Kawata K, Yang GX, Ando Y, Tanaka H, Zhang W, Kobayashi Y, Tsuneyama K, et al. 2013

[雑誌論文] Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.

Kawata K, Tsuda M, Yang GX, Zhang W, Tanaka H, Tsuneyama K, Leung P, He XS, Knechtle S, Ansari AA, Coppel RL, Gershwin ME. 2013

[雑誌論文] Autoimmune features in metabolic liver disease: a single-center experience and review of the literature.

Tsuneyama K, Baba H, Kikuchi K, Nishida T, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Masuda S, Terada M, Imura J, Selmi C. 2013

[雑誌論文] Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome

Ichimura M, Kato S, Tsuneyama K, et al. 2013

[雑誌論文] Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(l) receptors : elucidation using organic hippocampal slice cultures.

Inada C, Thi Le X, Tsuneyama K, et al. 2013

[学会発表] DIAR Mice with Neonatal MSG Treatment Showed Macrovesicular Steatosis with Lobular Inflammation and Atypical Nodules in the Liver

7) Tsuneyama K, Nishida T, Nomotro K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Sasaki Y, Nakamura S, Hokao R, Imura J. 2013

[雑誌論文] STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.

Deng YR, Ma HD, Tsuneyama K, Yang W, Wang YH, Lu FT, Liu CH, Liu P, He XS, Diehl AM, Gershwin ME, Lian ZX. 2013

[雑誌論文] Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet.

Watanabe S, Tsuneyama K. 2013

[雑誌論文] The liver in itai-itai disease (chronic cadmium poisoning): pathological features and metallothionein expression.

Baba H, Tsuneyama K, Yazaki M, Nagata K, Minamisaka T, Tsuda T, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Aoshima K, Imura J. 2013

[学会発表] 新生児期STZ処置DIARマウスは標準食で1型糖尿病，肝線維化，肝細胞癌を発症する．

19) 常山幸一，西田健志，野本一博，林伸一，三輪重治，中嶋隆彦，中西 ゆう子，八田 秀樹，井村穣二． 2013

[雑誌論文] Adipose tissue hypoxia induces inflammatory Ml polarity of macrophages in an HIF-la-dependent and HIF-la-independent manner in obese mice.

Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, Mahmood A, Goda N, Nagai Y, Takatsu K, Tobe K. 2013

[雑誌論文] A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.

Sasaki E, Matsuo K, Iida A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T. 2013

[雑誌論文] Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreaticβ-cell failure in type 2 diabetes.

Han D, Yamamoto Y, Munesue S, Motoyoshi S, Saito H, Win MT, Watanabe T, Tsuneyama K, Yamamoto H. 2013

[雑誌論文] Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular carcinoma in a mouse model of metabolic syndrome.

Nishida T, Tsuneyama K, et a1. 2013

[雑誌論文] Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C.

Yamaguchi T, Matsuzaki K, Inokuchi R, Kawamura R, Yoshida K, Murata M, Fujisawa J, Fukushima N, Sata M, Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, et al. 2013

[雑誌論文] Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis.

Dhirapong A, Yang GX, Nadler S, Zhang W, Tsuneyama K, et al. 2013

[学会発表] Neonatal streptozotocin treatment in DIAR mice causes insulin-dependent diabetes mellitus and hepatocellular carcinoma by normal diet.

6) Tsuneyama K, Nishida T, Fujimoto M, Hayashi S, Nomoto K, Miwa S, Nakajima T, Nakanishi Y, Sasaki Y, Nakamura S, Hokao R, Imura J. 2013

[学会発表] Neonatal MSG treatment in DIAR mice causes macrovesicular steatosis with lobular inflammation in the liver

Nishida T, Tsuneyama K, et al. 2013

[雑誌論文] The liver in itai-itai disease (chronic cadmium poisoning) : Pathological features and metallothionein expression.

Baba H, Tsuneyama K, et al. 2013

[学会発表] TSOD MICE: A new model of spontaneous non-alcoholic steatohepatitis and hepatocellular carcinoma based on obesity, type-2 diabetes and Hyperlipidemia.

Nishida T, Fujimoto M, Tsuneyama K. 2012

[雑誌論文] Animal models of primary biliary cirrhosis: materials and methods.

Leung PS, Yang GX, Dhirapong A, Tsuneyama K, et al. 2012

[雑誌論文] Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease.

Nomoto K, Nishida T, Nakanishi Y, Fujimoto M, Takasaki I, Tabuchi Y, Tsuneyama K. 2012

[学会発表] PBCモデルマウスと日本人留学生

常山幸一 2012

[雑誌論文] Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries.

Yoshikawa Y, Miyashita T, Higuchi S, Tsuneyama K, et al. 2012

[雑誌論文] Identification of innate IL-5-producing cells and their role in lung eosin ophil regulation and antitumor immunity.

Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, et al. 2012

[雑誌論文] The immunobiology of colitis and cholangitis in interleukin-23pl9 and interleukin-17A deleted dominant negative form of transforming growth factor beta receptor type II mice.

Ando Y, Yang GX, Tsuda M, Kawata K, Zhang W, Nakajima T, Tsuneyama K, et al. 2012

[雑誌論文] Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβreceptor II.

Zhang W, Tsuda M, Yang GX, Tsuneyama K, et al. 2012

[雑誌論文] Metabolic activation and inflammation reactions involved in carbamazepine-induced liver injury.

Higuchi S, Yano A, Takai S, Tsuneyama K, et al. 2012

[雑誌論文] The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.

Shimoda S, Tsuneyama K, et al. 2012

[雑誌論文] Study of the effects of monacolin k and other constituents of red yeast rice on obesity, insulin-resistance, hyperlipidemia, and nonalcoholic steat ohepatitis using a mouse model of metabolic syndrome.

Fujimoto M, Tsuneyama K, et al. 2012

[雑誌論文] The radioprotective 105/MD-l complex contributes to diet-induced obesity and adipose tissue inflammation.

Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, et al. 2012

[雑誌論文] Mass Spectrometry Imaging of the Capsaicin Localization in the Capsicum Fruits.

Taira S, Shimma S, Osaka I, Kaneko D, Ichiyanagi Y, Ikeda R, Konishi-Kawamura Y, Zhu S, Tsuneyama K, Komatsu K. 2012

[雑誌論文] Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models

Miyashita T, Toyoda Y, Tsuneyama K, et al. 2012

[雑誌論文] Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts.

Matsubara T, Sato Y, Sasaki M, Harada K, Nomoto K, Tsuneyama K, et al. 2012

[雑誌論文] Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PD GF mechanisms in the brain.

Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, et al. 2012

[雑誌論文] Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome.

Fujimoto M, Tsuneyama K, et al. 2012

[学会発表] Nano-PALDIイメージング質量分析を用いた低分子Xenobiotics（２オクチン酸）検出法の開発

常山幸一、菊池健太郎、守時由起、井村穣二、平修 0

[学会発表] 自然発症メタボリックシンドローム-発癌モデル（TSODマウス）の肝腫瘍の特徴

常山 幸一、西田 健志、野本一博、林伸一、三輪重治、中嶋隆彦、八田秀樹、井村穣二 0

[学会発表] Establishment of repeated liver biopsy technique in experimental mice

Tsuneyama K, Baba H, Nakajima T, Nishida T, Imura J. 0

[学会発表] イメージングMSの病理診断学への応用と展開

常山　幸一、井村　穣二 0

[学会発表] Daily moderate coffee intake inhibits pancreatic beta-cell damage and nonalcoholic steatohepatitis without improving obesity in a mouse model of spontaneous metabolic syndrome

Koichi Tsuneyama, Hayato Baba, Takeshi Nishida, Hideki Hatta, Johji Imura 0