トップ›研究者を探す›ユビキチン分解異常による細胞周期制御の破綻がもたらす癌化機構の解明

ユビキチン分解異常による細胞周期制御の破綻がもたらす癌化機構の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23689074
研究種目 若手研究(A)
研究分野 生物系
医歯薬学
歯学
形態系基礎歯科学
研究機関 徳島大学
広島大学
代表研究者 工藤 保誠
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額（合計） 27,560,000 (直接経費 :21,200,000、間接経費 :6,360,000)
配分額（履歴） 2013年度：7,540,000 (直接経費 :5,800,000、間接経費 :1,740,000)
2012年度：7,540,000 (直接経費 :5,800,000、間接経費 :1,740,000)
2011年度：12,480,000 (直接経費 :9,600,000、間接経費 :2,880,000)
キーワード 細胞周期
ユビキチン分解
癌
APC/Cユビキチンリガーゼ複合体
細胞分裂
APC/C
Geminin
Aurora-A

研究成果

[学会発表] Chromosome passenger complex protein Borealin is regulated by APC/C^<Cdh>1 ubiquitin ligase complex

Tsunematsu T, Kudo Y 2013

[雑誌論文] Selective enhancing effect of Early mitotic inhibitor 1 depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells

Shimizu, N., Nakajima, N.I., Tsunematsu, T., Ogawa, I., Kawai, H., Hirayama, R., Fujimori, A., Okayasu, R., Ishimaru, N., Takata, T., Kudo, Y. 2013

[学会発表] Chromosome passenger complex protein,Borealin is regulated by APC/CCdh1 ubiquitin ligase complex,

Tsunematsu Takaaki and Yasusei Kudo 2013

[学会発表] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin and CDT1 in mitosis

Yasusei Kudo, Tsunematsu Takaaki and Naozumi Ishimaru 2013

[学会発表] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin and Cdt1 in mitosis

Yasusei Kudo, Tsunematsu Takaaki and Naozumi Ishimaru 2013

[学会発表] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin and Cdt1 in mitosis

Kudo Y, Tsunematsu T, Ishimaru N 2013

[学会発表] 分裂期においてGemininはAurora-Aによるリン酸化によってユビキチン分解を免れる

常松貴明,工藤保誠,高田隆 2012

[学会発表] 分裂期キナーゼAurora-AによるDNAライセンス化抑制因子Gemininの安定化機構

常松貴明,工藤保誠,高田隆 2012

[雑誌論文] The Cyclin F-Ribonucleotide Reductase M2 axis controls genome integrity and DNA repair

D'Angiolella, V., Donate, V., Forrester, F. M., Jeong, Y. T., Pellacani, C., Kudo, Y., Saraf, A., Florens, L., Washburn, M. P., Pagano, M. 2012

[学会発表] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin and Cdt1 in mitosis.

Kudo Y 2012

[雑誌論文] Overexpression of Receptor for Hyaluronan-Mediated Motility (RHAMM) in MC3T3-E1 induces the proliferation and differentiation through phosphorypation of ERK1/2

Hatano, H., Shigeishi, H., Kudo, Y., Higashikawa, K., Tobiume, K., Takata, T., Kamata, N. 2012

[学会発表] 分裂期において染色体パッセンジャータンパクであるBorealinは,APC/C^<Cdh>1ユビキチンリガーゼ複合体により制御される

工藤保誠,常松貴明,近藤智之,石丸直澄,高田隆 2012

[学会発表] 細胞分裂期キナーゼAurora-AによるDNA複製調節機構

常松貴明,工藤保誠,高田隆 2012

[学会発表] Aurora-A controls pre-replicative complex formation and DNA replication by promoting the stabilization of geminin and Cdt1 in mitosis

Kudo Y, Tsunematsu T, Takata T 2012

[雑誌論文] The Cyclin F-Ribonucleotide Reductase M2 axis controls genome integrity and DNA repair

D'Angiolella, V., Donate, V., Forrester, F.M., Jeong, Y.T., Kudo, Y., et al 2012

[学会発表] 染色体パッセンジャータンパクであるBorealinは，APC/C-Cdh1ユビキチンリガーゼ複合体により制御される

工藤 保誠 2012

[雑誌論文] Overexpression of Receptor for Hyaluronan-Mediated Motility (RHAMM) in MC3T3-E1 induces the proliferation and differentiation through phosphorypation of ERK1/2

Hatano, H., Shigeishi, H., Kudo, Y., et al 2012

[雑誌論文] miR-22 represses cancer progression by inducing celular senescence

Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., Tamaki, A., Takata, T., Shimamoto, A., Ochiya, T., Tahara, H. 2011

[雑誌論文] SCFSSTrcp mediates stress-induced Cdc25B ubiquitylation through cooperation of an atypical consensus sequence and PEST

Uchida, S., Watanabe, N., Kudo, Y., et al 2011

[学会発表] Geminin stabilization by Aurora kinase-mediated phosphorylation during mitosis

Tsunematsu T, Kudo Y, Takata T 2011

[学会発表] Identification of novel invasion related molecules in oral cancer

工藤保誠 2011

[雑誌論文] miR-22 represses cancer progression by inducing cellular senescence

Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., et al 2011

[雑誌論文] MMP-10/stromelysin-2 promotes invasion of head and neck cancer

Deraz, E.M., Kudo, Y., et al 2011

[学会発表] Geminin stabilization by Aurora kinase-mediated phosphorylation during mitosis

Tsunematsu T, Kudo Y, Takata T 2011

[雑誌論文] SCF^<ßTrcp>mediates stress-induced Cdc25B ubiquitylation through cooperation of an atypical consensus sequence and PEST

Uchida, S., Watanabe, N., Kudo, Y., Yoshioka, K., Matsunaga, T., Ishizuka, Y., Nakagama, H., Poon, R.Y.C., Yamashita, K. 2011

[雑誌論文] MMP-10/stromelysin-2 promotes invasion of head and neck cancer

Deraz, E.M., Kudo, Y., Yoshida, M., Tani, H., Tsunematsu, T., Siriwardena, B.S.M.S., Kiekhaee, M.R., Qi, G., Iizuka, S., Ogawa, I., Campisi, G., Lo Muzio, L., Abiko, Y., Kikuchi, A., Takata, T. 2011

[学会発表] Chromosome passenger complex protein, Borealin is regulated by APC/C^<Cdh>1 ubiquitin ligase complex

Kudo Y, Tsunematsu T, Takata T 2011

[学会発表] Chromosome passenger complex protein, Borealin is regulated by APC/C^<Cdhl> ubiquitin ligase complex

Kudo Y, Tsunematsu T, Takata T 2011

[学会発表] Identification of novel invasion related molecules in oral cancer

工藤保誠 2011