研究成果

[雑誌論文] Influence of urethane-anesthesia on the effect of resiniferatoxin treatment on bladder function in rats with spinal cord injury.

Aizawa N, Ogawa S, Sugiyama R, Homma Y, Igawa Y 2014

[雑誌論文] Changes in the Function and Expression of T-Type and N-Type Calcium Channels in the Rat Bladder after Bladder Outlet Obstruction.

Igawa Y, Kumano S, Aizawa N, Saito Y, Ito H, Watanabe S, Takahashi N, Tajimi M, Nishimatsu H, Homma Y. 2014

[雑誌論文] The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat.

Minagawa T, Aizawa N, Igawa Y, Wyndaele JJ 2014

[雑誌論文] Effects of L-arginine, mirabegron, and oxybutynin on the primary bladder afferent nerve activities synchronized with reflexic, rhythmic bladder contractions in the rat.

Aizawa N, Homma Y, Igawa Y 2014

[雑誌論文] Inhibition of peripheral fatty acid amide hydrolase depresses activities of bladder mechanosensitive nerve fibers of the rat.

Aizawa N, Hedlund P, Füllhase C, Ito H, Homma Y, Igawa Y 2014

[学会発表] Urothelium inhibits β-adrenoceptor-mediated relaxation in human detrusor smooth muscle via CAMP- and P2 purinoceptor-dependent mechanism

Igawa Y, Kumano S, Aizawa N, Ito H, Sugiyama R, Homma Y 2013

[学会発表] Effects of TRPM8 channels' inhibition on concious cystometry and single-unit mechanosensitive bladder afferent activities in novel ex vivo model of the rat

Ito H,Aizawa N,Sugiyama R, Watanabe S, Takahashi N, Tajimi M, Homma Y, Kubota Y, Igawa Y 2013

[学会発表] Effects of silodosin, a selective α1A-adrenoceptor antagonist, on the single primary bladder afferent activity of the rat

Aizawa N,Homma Y,Igawa Y 2013

[雑誌論文] Characteristics of lower urinary tract dysfunction and bladder afferent nerve properties in type 2 diabetic goto-kakizaki rats.

Aizawa N, Homma Y, Igawa Y. 2013

[学会発表] Synergic supressive effect of the conbination therapy with silodosin and imidafenacin on non-voiding contractions in male rats with sub-acute bladder outlet obstruction

Sugiyama R, Aizawa N, Homma Y, Igawa Y 2013

[雑誌論文] Influence of high fat diet feeding for 20 weeks on lower urinary tract function in mice.

Aizawa N, Homma Y, Igawa Y. 2013

[学会発表] Effect of silodosin, a selective alpha1A-adrenoceptor antagonist on primary bladder afferent activity and bladder microcontractions in rats

Aizawa N, Homma Y, Igawa Y 2013

[学会発表] Inhibitory effect of retigabine, a Kv7 channel activator, on rhythmic bladder contractions and mechanosensitive primary bladder afferent activities in rats

Aizawa N,Wakamatsu D, Matsuya H, Homma Y,Igawa Y 2013

[学会発表] Age-related changes in detrusor properties and gene expression in the bladder and dorsal root ganglion of the rat and preventative effect of low caloric diet ageinst these changes

Ito H, Aizawa N, Fujita Y, Kojima T, Ito M, Homma Y, Kubota Y, Igawa Y 2013

[雑誌論文] Mechanisms of pelvic organ cross-talk: 2. Impact of colorectal distention on afferent nerve activity of the rat bladder.

Minagawa T, Wyndaele M, Aizawa N, Igawa Y, Wyndaele JJ. 2013

[学会発表] Elevated urinary CXCL10 correlates with symptom severity in patients with ulcer type interstitial cystitis

Igawa Y, Nomiya A,Homma T,Aizawa N,Nishimatsu H,Akahane S,Homma Y 2012

[学会発表] Elevated urinary CXCL10 correlates with symptom severity in patients with ulcer type interstitial cystitis

Igawa Y, Nomiya A,Homma T, Aizawa N, Nishimatsu H, Akahane S, Homma Y 2012

[雑誌論文] Inhibitory effects of phosphodiesterase 5 inhibitor, tadalafil, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves.

Minagawa T, Aizawa N, Igawa Y, Wyndaele JJ. 2012

[学会発表] Effects of sildenafil,a phosphodiesterase type 5 inhibitor,on the primary single afferent activity of the rat bladder

Aizawa N,Homma Y,Igawa Y 2012

[学会発表] Effects of mirabegron (YM178), a novel beta3-adrenoceptor agonist, on the primary bladder afferent activity of the rat

Aizawa N, Homma Y, Igawa Y 2011

[学会発表] Effects of L-arginine on single unit bladder afferent activities synchronized with rhythmic bladder contractions in the rat

Aizawa N, Wyndaele JJ, Homma Y, Igawa Y 2011

[学会発表] 新規β3受容体作動薬ミラベグロン(YM178)の、膀胱伸展時および律動性収縮時のラット膀胱一次求心性神経活動に対する直接作用

相澤直樹、本間之夫、井川靖彦 2011

[学会発表] ラット膀胱伸展受容－次求心神経活動に対する内因性一酸化窒素（ON）の抑制作用

相澤直樹、井川靖彦、西沢　理、本間之夫、ウィンダーレ　ジョンジャック 2011

[学会発表] 高脂肪食誘発メタボリック症候群マウスの下部尿路機能解析

相澤直樹、本間之夫、井川靖彦 2011

[雑誌論文] Comparison of the effects of oestrogen deficiency and old age on primary bladder afferent activity and voiding behavior in the ageing female rat

Aizawa N, Iijima K, Rosenbaum JS, Downs TR, Igawa Y, Andersson KE, Wyndaele JJ 2011

[学会発表] TRPV4チャネルを介するラット膀胱伸展受容一次求心性神経活動の促進機構

相澤直樹、ウィンダーレ　ジョンジャック、本間之夫、井川靖彦 2011

[学会発表] L-Arginineの律動性膀胱収縮およびそれに同期する膀胱一次求心性神経活動に対する抑制作用

相澤直樹、ウィンダーレ　ジョンジャック、本間之夫、井川靖彦 2011

[学会発表] Direct effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat

Aizawa N, Wyndaele JJ, Homma Y, Igawa Y 2011

[学会発表] Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat.

Aizawa N, Wyndaele JJ, Homma Y, Igawa Y 2011

[学会発表] Effects of TRPM8 channels’ inhibition on conscious cystometry and single-unit mechanosensitive bladder afferent activities in novel EX VIVO model of the rat

Ito H, Aizawa N, Sugiyama R, Watanabe S, Takahashi N, Tajimi M, Homma Y, Kubota Y, Igawa Y

[学会発表] Selective inhibitory effect of imidafenacin, a novel anticholinergic agent, on capsaicin-sensitive C-fibers among the primary bladder mechanosensitive afferent nerves in the rat

Aizawa N, Homma Y, Igawa Y

[学会発表] Effects of silodosin, a selective α1A-adrenoceptor antagonist, on the single primary bladder afferent activity of the rat.

Aizawa N,Homma Y,Igawa Y

[学会発表] Effects of RQ-00311610, a novel T-type calcium channel inhibitor, on bladder function and blood pressure in rats with bladder outlet obstruction.

Kumano S, Aizawa N, Ogawa S, Homma Y, Watanabe S, Takahashi N, Tajimi M, Igawa Y

[学会発表] Comparison of the effects of Mirabegron, a novel beta3-adrenoceptor agonist, with the anticholinergic agent, Oxybutinin, on primary bladder afferent activity and microcontractions in rats.

Aizawa N, Homma Y, Igawa Y

[学会発表] Changes in function and expression of N-type calcium channels in the rat bladder after bladder outlet obstruction

Kumano S, Aizawa N, Homma Y, Igawa Y

[学会発表] Inhibition of fatty acid amide hydrolase suppresses mechanosensitive primary bladder afferent activies in the rat

Aizawa N, Fullhase C, Hedlund P, Homma Y, Igawa Y

[学会発表] Urothelium inhibits β-adrenoceptor-mediated relaxation in human detrusor smooth muscle via camp- and P2 purinoceptor-dependent mechanism

Igawa Y, Kumano S, Aizawa N, Ito H, Sugiyama R, Homma Y

[学会発表] 治療標的としての膀胱求心性神経伝達路

相澤直樹、本間之夫、井川靖彦

[学会発表] Inhibitory effect of retigabine, a Kv7 channel activator, on rhythmic bladder contractions and mechanosensitive primary bladder afferent activities in rats

Aizawa N, Wakamatsu D, Matsuya H, Homma Y, Igawa Y

[学会発表] Influence of urethane anaesthesia on the effect of resiniferatoxin treatment on detrusor overactivity in rats with spinal cord injury.

Ogawa S, Aizawa N, Homma Y, Igawa Y

[学会発表] Impact of rectal distension on primary bladder mechanosensitive afferent nerve activities in the rat: Mechanism of a peripheral afferent origin of pelvic organ cross-sensitization.

Minagawa T, Wyndaele M, Aizawa N, Igawa Y, Wyndaele JJ

[学会発表] Negligible Influence of High Fat Diet Feeding on Lower Urinary Tract Function in Mice.

Aizawa N, Homma Y, Igawa Y

[学会発表] The role of TRPA1 channels in activation of single unit mechanosensitive bladder afferent activities in the rat.

Minagawa T, Wyndaele JJ, Aizawa N, Igawa Y

[学会発表] Effects of mirabegron, a β3-adrenoceptor agonist, on the primary bladder afferent activity synchronized with rhythmic bladder contractions in rats in comparison with those of oxybutynin

Aizawa N, Homma Y, Igawa Y

[学会発表] Synergic suppressive effect of the combination therapy with silodosin and imidafenacin on non-voiding bladder contractions in male rats with sub-acute bladder outlet obstruction

Sugiyama R, Aizawa N, Homma Y, Igawa Y

[学会発表] Effects of TRPM8 channels' inhibition on concious cystometry and single-unit mechanosensitive bladder afferent activities in novel ex vivo model of the rat

Ito H, Aizawa N, Sugiyama R, Watanabe S, Takahashi N, Tajimi M, Homma Y, Kubota Y, Igawa Y

[学会発表] Peripheral inhibition of fatty acid amide hydrolase depresses activities of single primary bladder mechanosensitive afferents of the rat

Aizawa N,C.Fullhase,P.Hedlund,Homma Y,Igawa Y