トップ研究者を探す皮膚指向性成熟T細胞腫瘍においてFra-2-SOX4経路が担う発癌機構の解明

皮膚指向性成熟T細胞腫瘍においてFra-2-SOX4経路が担う発癌機構の解明

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23591632
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
皮膚科学
研究機関 近畿大学
代表研究者 樋口 智紀
研究分担者 義江 修
研究分担者 中山 隆志
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2013年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2012年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2011年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード 皮膚腫瘍学
SOX4
Fra-2
成人T細胞白血病/リンパ腫(ATL)
皮膚T細胞リンパ腫(CTCL)
HDAC8
ATL
CTCL
ATLL

研究成果

[雑誌論文] Generation of colonic IgA-secreting cells in the caecal patch.

Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima et al. 2014

[学会発表] Attenuation of bleomycin-induced mice pulmonary fibrosis by in vivo treatment of HSP27 siRNA.

Ah-Mee Park, Osamu Yoshie, Akiko Watanabe, Tomonori Higuchi, Eiko Honda, Hiroshi Munakata 2014

[学会発表] Attenuation of bleomycin-induced mice pulmonary fibrosis by in vivo treatment of HSP27 siRNA

Park AM, Yoshie O, Watanabe A, Higuchi T, Honda E, Munakata H 2014

[学会発表] Fra-2-SOX4 oncogenic cascade plays a critical role in cell growth of adult T-cell leukemia/lymphoma

Higuchi T, Nakayama T, Yoshie O 2013

[学会発表] Fra-2-SOX4 oncogenic cascade plays a critical role in cell growth of adult T-cell leukemia/lymphoma.

Tomonori Higuchi, Takashi Nakayama, Osamu Yoshie. 2013

[雑誌論文] SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.

Tomonori Higuchi et al. 2013

[学会発表] Induction of FosB by Tax induces CCL22 in HTLV-1-infected T cells, leading to HTLV-1

Tomonori Higuchi et al. 2012

[学会発表] Induction of FosB by Tax induces CCL22 in HTLV-1-infected T cells, leading to HTLV-1

Higuchi T, Hieshima K, Nakayama T, Yoshie O 2012

[雑誌論文] Expression and function of FRA2/JUND in cutaneous T-cell lymphomas

Nakayama T, Higuchi T, Oiso N, Kawada A, Yoshie O 2012

[学会発表] Fra-2-SOX4 oncogenic cascade plays a critical role in cell growth of CCR4+ mature T-cell malignancies

Tomonori Higuchi et al. 2011

[学会発表] Fra-2-SOX4 oncogenic cascade plays a critical role in cell growth of CCR4+ mature T-cell malignancies

Higuchi T, Nakayama T, Shigeta A, Yoshie O 2011

[学会発表] CCL26/eotaxin-3 attracts killer lymphocytes by intracting with CX3CR1

Nakayama T, Higuchi T, Shigeta A, Yoshie O 2011