肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用

トップ›研究者を探す›肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用

肺高血圧症におけるプロテイナーゼ活性化型受容体の役割解明と治療応用

代表研究者	平野勝也
研究課題番号	KAKENHI-PROJECT-23591104
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学循環器内科学
研究機関	九州大学
研究分担者	平野真弓
研究分担者	阿部弘太郎
研究分担者	小田義直
研究期間開始年月日	2011/4/1
研究期間終了年度	2013
研究ステータス	完了 (2013/4/1)
配分額（合計）	5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
配分額（履歴）	2013年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000) 2012年度：1,690,000 (直接経費 :1,300,000、間接経費 :390,000) 2011年度：1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード	肺高血圧血管内皮細胞血管平滑筋細胞トロンビン受容体モデル動物受容体拮抗薬肺高血圧症

研究成果

[学会発表] Distinct role of mono- and di-phosphorylation of myosin light chain (MLC) in thrombin-induced endothelial barrier disruption

Hirano K, Hirano M 2014

[学会発表] Role of mono- and di-phosphorylation of myosin light chain in thrombin-induced endothelial barrier disruption

Hirano M, Hirano K 2014

[学会発表] Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role in thrombin-induced endothelial barrier disruption

Hirano K, Hirano M 2014

[雑誌論文] プロテイナーゼ活性化型受容体を標的とした肺高血圧治療の可能性

平野勝也 2014

[学会発表] Preventive effects of thrombin receptor antagonist on hemodynamic parameters and histological findings in monocrotaline-induced pulmonary hypertension rats

Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K 2014

[雑誌論文] 肺高血圧症の薬物治療の最前線:序文

平野勝也、渡邉裕司 2014

[学会発表] A new endothelin receptor antagonist macitentan prevents endothelin-1-induced contraction in intrapulmonary arteries in rats with severe pulmonary arterial hypertension

Kunita M, Abe K, Hirooka Y, Hirano K, Sunagawa K 2013

[学会発表] Myosin light chain di-phosphorylation at sub-membranous region plays a critical role during thrombin-induced barrier disruption in vascular endothelial cells

Hirano M, Hirano K 2013

[学会発表] Critical role of Rho-kinase-mediated subjunctional di-phosphorylation of myosin light chain (MLC) in thrombin-induced disruption of endothelial barrier

Hirano K, Hirano M 2013

[学会発表] トロンビン受容体を標的とした新たな肺高血圧治療ストラテジーの確立Vascular Biology Innovation

阿部弘太郎、平野勝也 2013

[学会発表] Crucial role of proteinase-activated receptor 1 in the development of monocrotaline induced pulmonary arterial hypertension in rats.

55. Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K 2013

[学会発表] A New Endothelin Receptor Antagonist Macitentan is a Potent Vasodilator in Intrapulmonary Arteries in Rats with Severe Pulmonary Hypertension

Kunita M, Abe K, Hirano K, Sunagawa K, Hirooka Y 2013

[学会発表] A new endothelin receptor antagonist macitentan is a potent vasodilator in intrapulmonary arteries in rats with severe pulmonary hypertension

Kunita M, Abe K, Hirano K, Sunagawa K, Hirooka Y 2013

[学会発表] A New Strategy for Treatment of Pulmonary Hypertension with Thrombin Receptor as a Therapeutic Target

平野勝也 2013

[学会発表] A novel endothelin receptor antagonist, macitentan markedly improved severe pulmonary arterial hypertension in rats by a nearly complete blockade of endothelin receptors

Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K 2013

[学会発表] Chronic administration of proteinase- activated receptor 1 (PAR1) antagonist attenuated monocrotaline-induced pulmonary hypertension in rats

Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K 2013

[学会発表] Rho kinase-mediated di-phosphorylation of myosin light chain in the sub-membranous regions and circumferential actomyosin contraction mediate thrombin-induced barrier disruption in vascular endothelial cells

Hirano M, Hanada A, Hirano K 2013

[学会発表] Di-phosphorylation of myosin light chain and actin fiber formation in the submembranous region at inter- endothelial junction play a crucial role in thrombin-induced endothelial barrier disruption

Hirano M, Hirano K 2013

[学会発表] 新薬マシテンタンは肺高血圧モデルラットの病態進行を抑制する

國田睦、阿部弘太郎、廣岡良隆、桑原志実、平野勝也、砂川賢二 2013

[学会発表] Chronic Administration of Proteinase-Activated Receptor 1 (PAR1) Antagonist Attenuated Monocrotaline-Induced Pulmonary Hypertension in Rats.

Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K 2013

[学会発表] A new strategy for treatment of pulmonary hypertension with thrombin receptor as a therapeutic target

Hirano K 2013

[学会発表] Di-phosphorylation of myosin light chain and actin fiber formation in the submembranous region at inter-endothelial junction play a crucial role in thrombin-induced endothelial barrier disruption.

56. Hirano M, Hirano K 2013

[学会発表] トロンビン受容体拮抗薬はモノクロタリン誘発肺高血圧を抑制する

桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二 2013

[学会発表] Crucial role of proteinase-activated receptor 1 in the development of monocrotaline induced pulmonary arterial hypertension in rats

Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K 2013

[学会発表] 血管平滑筋細胞トロンビン受容体の脱感作障害のメカニズム

平野真弓、平野勝也 2013

[学会発表] モノクロタリン誘発肺高血圧に対するトロンビン受容体拮抗薬の予防効果

平野勝也、桑原志実、平野真弓、阿部弘太郎 2013

[学会発表] くも膜下出血後脳血管攣縮におけるプロテイナーゼ活性化型受容体1の役割

平野勝也 2013

[学会発表] 肺高血圧症におけるトロンビン受容体の役割と新たな治療標的としての可能性

平野勝也 2012

[学会発表] Contribution of Rho-kinase and oxidative stress to the thrombin- induced pulmonary vasoconstriction

Hirano K, Hirano M 2012

[学会発表] Di-phosphorylation of myosin light chain (MLC) in the sub-membranous region plays an important role in the thrombin-induced barrier dysfunction in endothelial cells

Hirano M, Hirano K 2012

[学会発表] Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction

Hirano M, Hanada A, Hirano K 2012

[学会発表] Potential of Thrombin Receptor as a New Therapeutic Target for Treatment of Pulmonary Hypertension

平野勝也 2012

[学会発表] Potential of Thrombin Receptor as a New Therapeutic Target for Treatment of Pulmonary Hypertension

Hirano K, Abe K 2012

[学会発表] 肺高血圧症におけるトロンビン受容体の役割と新たな治療標的としての可能性

平野勝也 2012

[学会発表] Ca^<2+>-independent di-phosphorylation of myosin light chain by Rho-associated coiled-coil protein kinase (ROCK) in the subjunctional regions of cell-cell contact mediates thrombin-induced barrier dysfunction in vascular endothelial cells

Hirano M, Hanada A, Hirano K 2011

[学会発表] トロンビンが引き起こす内皮透過性亢進には細胞膜直下におけるミオシン軽鎖の2リン酸化が重要な役割を果たす

平野勝也、平野真弓、花田亜希子 2011

[雑誌論文] トロンビン受容体拮抗薬

平野勝也 2011

[学会発表] Ca2+-independent di-phosphorylation of myosin light chain by rho-associated coiled-coil protein kinase (ROCK) in the subjunctional regions of cell-cell contact mediates thrombin-induced barrier dysfunction in vascular endothelial cells

Hirano M, Hanada A, Hirano K

[学会発表] Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction.

Hirano M, Hanada A, Hirano K

[学会発表] トロンビンが引き起こす内皮透過性亢進には細胞膜直下におけるミオシン軽鎖の2リン酸化が重要な役割を果たす

平野勝也、平野真弓、花田亜希子

[雑誌論文] Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats

Kunita-Takanezawa M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K