肥大型心筋症の病因遺伝子解析と病態修飾因子の解明

トップ›研究者を探す›肥大型心筋症の病因遺伝子解析と病態修飾因子の解明

代表研究者	久保亨
研究課題番号	KAKENHI-PROJECT-23591049
研究種目	基盤研究(C)
研究分野	生物系医歯薬学内科系臨床医学循環器内科学
研究機関	高知大学
研究分担者	北岡裕章
研究分担者	土居義典
研究期間開始年月日	2011/4/1
研究期間終了年度	2015
研究ステータス	完了 (2015/4/1)
配分額（合計）	5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
配分額（履歴）	2015年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2014年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2013年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2012年度：1,040,000 (直接経費 :800,000、間接経費 :240,000) 2011年度：1,170,000 (直接経費 :900,000、間接経費 :270,000)
キーワード	肥大型心筋症遺伝子変異サルコメア遺伝子血液マーカートロポニン性差遺伝子臨床病型予後バイオマーカー臨床像

研究成果

[雑誌論文] Biomarkers related to hemodynamic abnormalities with high shear stress.

Kubo T, Kitaoka H. 2016

[雑誌論文] Erythrocyte creatine as a marker of intravascular hemolysis due to left ventricular outflow tract obstruction in hypertrophic cardiomyopathy.

Kubo T, Okumiya T, Baba Y, Hirota T, Tanioka K, Yamasaki N, Sugiura T, Doi YL, Kitaoka H. 2016

[雑誌論文] Gender differences in the clinical features of hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations

Terauchi, Kubo T, Baba Y, Hirota T, Tanioka K, et al. 2015

[学会発表] 肥大心におけるファブリー病の鑑別

久保亨 2015

[学会発表] 高感度心筋トロポニンT高値は肥大型心筋症患者の左室リモデリングと関連する

久保亨 2015

[学会発表] Prognostic significance of non-dilated left ventricular size and mitral regurgitation in patients wtih end-stage phase of hypertrophic cardiomyopathy.

Kubo T 2015

[学会発表] 肥大型心筋症診断患者におけるファブリー病の頻度と臨床像

久保亨 2015

[学会発表] 肥大心におけるファブリー病の鑑別

久保亨 2015

[学会発表] 原因不明の心肥大に潜むファブリー病の診断と治療（シンポジウム）

久保亨 2015

[学会発表] Elevation of serum high-sensitivity cardiac troponin T value is associated with progression of left ventricular remodeling in patients with hypertrophic cardiomyopathy.

Kubo T 2015

[雑誌論文] Cardiovascular disease in the elderly: management of atrial fibrillation and chronic heart failure.

Doi Y, Furuno T, Kubo T, Yamasaki N, Kitaoka H. 2014

[雑誌論文] Repeated heart failure in a 74-year-old man with left ventricular hypertrophy.

Ochi Y, Kubo T, Kitaoka H. 2014

[学会発表] Evaluation of intravascular hemolysis with erythrocyte creatine in hypertrophic cardiomyopathy patients with or without obstruction

Toru Kubo 2014

[雑誌論文] Cardiac Fabry disease

Kubo T. 2014

[雑誌論文] Gender differences in the clinical features of hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations

Terauchi, Kubo T, Baba Y, Hirota T, Tanioka K, et al. 2014

[雑誌論文] Tissue Doppler imaging and prognosis in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Hayashi K, Yamasaki N, Matsumura Y, et al. 2013

[雑誌論文] Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy

Kubo T, Kitaoka H, Yamanaka S, Hirota T, Baba Y, et al. 2013

[雑誌論文] Tissue Doppler imaging and prognosis in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy

Kitaoka H, Kubo T, Hayashi K, Yamasaki N, Matsumura Y, et ak. 2013

[学会発表] 肥大心におけるファブリー病の鑑別

久保亨 2013

[学会発表] 高感度心筋トロポニンTは、サルコメア遺伝子変異を有する肥大型心筋症と肥大型心筋症類似左室形態を呈する蓄積疾患との鑑別診断に有用である

久保亨 2013

[雑誌論文] Serum tenascin-C levels as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Baba Y, Yamasaki N, et al. 2012

[学会発表] Prognostic role of high-sensitivity cardia troponin T in hypertrophic cardiomyopathy

Kubo T 2012

[学会発表] Prognostic significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy

Kubo T 2012

[雑誌論文] Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation.

Kitaoka H, Kubo T, Okawa M, Takenaka N, Baba Y, et al. 2011

[雑誌論文] Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy.

Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, et al. 2011

[学会発表] Plasma tenescin-C level as a prognostic biomarker of heart failure events in patients with hypertrophic cardiomyopathy

Kitaoka H 2011

[雑誌論文] Tissue Doppler imaging and plasma BNP levels to assess the prognosis in patients with hypertrophic cardiomyopathy.

Kitaoka H, Kubo T, Okawa M, Takenaka N, Sakamoto C, et al. 2011

[雑誌論文] Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy.

Kubo T, Kitaoka H, Okawa M, Yamanaka S, Hirota T, Baba Y, Hayato K, Yamasaki N, et al. 2011

[学会発表] 血清心筋トロポニンI値はサルコメア遺伝子変異を有する肥大型心筋症患者の左室リモデリングと関連する

久保　亨 2011

[学会発表] Elevation of serum cardiac troponin I is associated with left ventricular remodeling in hypertrophic cardiomyopathy caused by sarcomere gene mutations

Kubo T 2011

[学会発表] Clinical profile of embolic events in patients with hypertrophic cardiomyopathy

Hirota Takayoshi, Totu Kubo 0

[学会発表] 拡張相肥大型心筋症患者の予後は、左室サイズ非拡大群や僧帽弁閉鎖不全症群で不良である

津田敦、久保亨、他 0

[学会発表] Clinical significance of a recent model for estimating sudden cardiac death in community-based hypertrophic cardiomyopathy cohort

Asa Takahashi, Toru Kubo 0

[学会発表] Prognostic significance of non-dilated left ventricular size and mitral regurgitation in patients with end-stage phase of hypertrophic cardiomyopathy

Toru Kubo 0

[学会発表] Elevation of Serum High-Sensitivity Cardiac Troponin T is Associated with Left Ventricular Remodeling in Hypertrophic Cardiomyopathy Caused by Sarcomere Gene Mutations

Toru Kubo 0

[学会発表] Elevation of serum high-sensitivity cardiac troponin T value is associated with progression of left ventricular remodeling in patients with hypertrophic cardiomyopathy

Toru Kubo 0