トップ研究者を探すヘパリンコファクターIIを用いた心筋梗塞後心臓リモデリングに対する新規治療法の開発

ヘパリンコファクターIIを用いた心筋梗塞後心臓リモデリングに対する新規治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23591046
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
循環器内科学
研究機関 徳島大学
代表研究者 岩瀬 俊
研究分担者 佐田 政隆
研究分担者 原田 雅史
研究分担者 粟飯原 賢一
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 4,940,000 (直接経費 :3,800,000、間接経費 :1,140,000)
配分額(履歴) 2013年度:910,000 (直接経費 :700,000、間接経費 :210,000)
2012年度:1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2011年度:2,210,000 (直接経費 :1,700,000、間接経費 :510,000)
キーワード 心筋梗塞後心筋リモデリング
心臓リモデリング
ヘパリンコファクターII
急性心筋梗塞

研究成果

[雑誌論文] Association of lower limb muscle mass and energy expenditure with visceral fat mass in healthy men

Yagi S, Kadota M, Aihara K, Nishikawa K, Hara T, Ise T, Ueda Y, Iwase T, Akaike M, Shimabukuro M, Katoh S, Sata M. 2014

[雑誌論文] Augmentation Index Does Not Reflect Risk of Coronary Artery Disease in Elderly Patients

Hayashi S, Yamada H, Bando M, Hotchi J, Ise T, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Tamaki T, Sata M. 2014

[学会発表] Impact of Cardiac Rehabilitation on Oxidized Stress in Patients with Heart Failure.

Ise T, Yagi S, Iwase T, Akaike M, Takashima A, Bando M, Bando S, Matsuura T, Hotchi J, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuiki T, Sata M. 2014

[雑誌論文] The physiological uptake pattern of (18)F-FDG in the left ventricular myocardium of patients without heart disease

Nose H, Otsuka H, Otomi Y, Terazawa K, Takao S, Iwamoto S, Iwase T, Yamada H, Sata M, Harada M. 2014

[雑誌論文] Androgen Receptor Promotes Sex-Independent Angiogenesis in Response to Ischemia and Is Required for Activation of Vascular Endothelial Growth Factor Receptor Signaling

Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T. 2013

[学会発表] Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance

Iwase T, Takao S, Akaike M, Ise T, Niki T, Ueda Y, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Aihara K, Wakatsuki T, Nishioka Y, Harada M, Sata M. 2013

[雑誌論文] Ulcer-like projection caused by a penetrating branch to the bronchial artery

Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M. 2013

[雑誌論文] Effects of Telmisartan on Inflammatory Cytokines and the Coronary Plaque Component as Assessed on Integrated Backscatter Intravascular Ultrasound in Hypertensive Patients

Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M. 2013

[学会発表] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance.

Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M 2013

[学会発表] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance

Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M. 2013

[雑誌論文] Constrictive pericarditis with intrapericardial abscess

Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M. 2013

[雑誌論文] Eosinophilic myocarditis due to Churg-Strauss syndrome with markedly elevated eosinophil cationic protein

Hara T1, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M. 2013

[学会発表] 左室収縮不全を伴う心サルコイドーシスと他の心疾患鑑別におけるガドリニウム遅延造影定量評価の有用性

岩瀬俊、高尾正一郎、赤池雅史、伊勢孝之、八木秀介、山口浩司、山田博胤、添木武、若槻哲三、西岡安彦、原田雅史、佐田政隆 2013

[雑誌論文] Effects of telmisartan on inflammatory cytokines and coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients

Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M. 2013

[学会発表] 3ステラ非造影心臓MRI検査が左室内壁在血栓の検出ならびに治療方針決定に有用であった無症候性心筋虚血の1例

岩瀬俊、高尾正一郎、太田理絵、山口浩司、赤池雅史、伊勢孝之、山田博胤、添木武、若槻哲三、原田雅史、佐田政隆 2013

[雑誌論文] Renin-angiotensin-aldosterone system has a pivotal role in cognitive impairment

Yagi S, Akaike M, Ise T, Ueda Y, Iwase T, Sata M. 2013

[雑誌論文] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling

Yoshida S, Aihara K, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama K, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T. 2013

[雑誌論文] Pentraxin 3 is a local inflammatory marker in atrial fibrillation

Soeki T, Bando S, Uematsu E, Matsuura T, Niki T, Ise T, Kusunose K, Hotchi J, Ueda Y, Tomita N, Yamaguchi K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M. 2013

[雑誌論文] Congenital long QT syndrome with compound mutations in the KCNH2 gene

Bando S, Soeki T, Matsuura T, Niki T, Ise T, Yamaguchi K, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Aiba T, Shimizu W, Sata M. 2013

[雑誌論文] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway

Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihara Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T. 2012

[学会発表] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure

Ise T, Yagi S, Iwase T, Akaike M, Kadota M, Hara T, Bando S, Niki T, Hotchi J, Tomita N, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M. 2012

[雑誌論文] High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension

Yagi S, Akaike M, Aihara K, Iwase T, Yoshida S, Sumitomo-Ueda Y, Ikeda Y, Ishikawa K, Matsumoto T, Sata M. 2011

[雑誌論文] Effect of Low-Dose (1 mg/day) Pitavastatin on Left Ventricular Diastolic Function and Albuminuria in Patients With Hyperlipidemia

Yagi S, Akaike M, Aihara KI, Iwase T, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Kusunose K, Niki T, Yamaguchi K, Koshiba K, Taketani Y, Tomita N, Yamada H, Soeki T, Wakatsuki T, Matsumoto T, Sata M. 2011

[雑誌論文] Plasma Heparin Cofactor II Activity is Inversely Associated with Left Atrial Volume and Diastolic Dysfunction in Humans with Cardiovascular Risk Factors

Ise T, Aihara KI, Sumitomo-Ueda Y, Yoshida S, Ikeda Y, Yagi S, Iwase T, Yamada H, Akaike M, Sata M, Matsumoto T. 2011

[学会発表] Detection of Cardiac Involvement in Patients with Sarcoidosis Using Cardiac Magnetic Resonance

Iwase T, Takao S, Akaike M, Ise T, Niki T, Kusunose K, Sumitomo-Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Yamada H, Soeki T, Aihara K, Wakatsuki T, Harada M, Sata M. 2011

[雑誌論文] Activation of peroxisome proliferator-activated receptorαin megakaryocytes reduces platelet-derived growth factor-BB in platelets

Hashizume S, Akaike M, Azuma H, Ishikawa K, Yoshida S, Sumitomo-Ueda Y, Yagi S, Ikeda Y, Iwase T, Aihara KI, Abe M, Sata M, Matsumoto T. 2011