トップ研究者を探す自己免疫性膵炎におけるBAFF,APRILの臨床的有用性についての検討

自己免疫性膵炎におけるBAFF,APRILの臨床的有用性についての検討

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23591014
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
消化器内科学
研究機関 愛媛大学
代表研究者 熊木 天児
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 5,070,000 (直接経費 :3,900,000、間接経費 :1,170,000)
配分額(履歴) 2013年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2012年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2011年度:1,950,000 (直接経費 :1,500,000、間接経費 :450,000)
キーワード 自己免疫性膵炎
膵癌
BAFF
APRIL
鑑別診断
治療効果判定
病態解明

研究成果

[雑誌論文] Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

Trivedi P, Bruns T, Cheung AC, Li KK, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Neuberger J, Janssen H, Hirschfield GM. 2014

[雑誌論文] Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation.

Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H, Hiasa Y 2014

[雑誌論文] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease.

Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, Ueda T, Hiasa Y, Matsuura B, Onji M. 2013

[学会発表] 膵癌進展に及ぼすB細胞活性化因子(BAFF)の作用

小泉光仁,日浅陽一,熊木天児,阿部雅則,松浦文三,恩地森一 2013

[学会発表] 新規化学療法時代における愛媛県膵癌診療の現状と展望

熊木天児,黒田太良,横田智行,清家裕貴,西山麻里,今井祐輔,稲田暢,柴田直純,今峰聡,岡田眞一,小泉光仁,山西浩文,畔元信明,長谷部昌,田中良憲,達川はるか,宇都宮大貴,恩地森一,日浅陽一 2013

[雑誌論文] Nonalcoholic fatty liver disease: Factors associated with its presence and onset.

Miyake T, Kumagi T, Furukawa S, Tokumoto Y, Hirooka M, Abe M, Hiasa Y, Matsuura B, Onji M. 2013

[雑誌論文] Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: A collaborative retrospective multicenter clinical review of 1,082 patients.

Kuroda T, Kumagi T, Yokota T, Seike H, Nishiyama M, Imai Y, et al., as the Ehime Pancreato-Cholangiology (EPOCH) Study Group. 2013

[学会発表] 新規化学療法時代における愛媛県膵癌診療の現状と展望

熊木天児,黒田太良,横田智行,清家裕貴,西山麻里,今井祐輔,稲田 暢,柴田直純,今峰 聡,岡田眞一,小泉光仁,山西浩文,畔元信明,長谷部昌,田中良憲,達川はるか,宇都宮大貴,恩地森一,日浅陽一 2013

[雑誌論文] 当科で経過をおえた膵癌stageIVb死亡症例における予後因子の検討

畔元信明、熊木天児、黒田太良, 他 2013

[学会発表] 高齢者に対する膵癌診療の実態および問題点

黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一、横田智行、清家裕貴、長谷部昌、今井祐輔、田中良憲、稲田暢 2013

[学会発表] Increased B cell-activating factor promotes epithelial-mesenchymal transition in human pancreatic cancer

Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Abe M, Ikeda Y, Matsuura B, Onji M 2013

[学会発表] Increased B cell-activating factor promotes epithelial- mesenchymal transition in human pancreatic cancer

Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Abe M, Ikeda Y, Matsuura B, Onji M. 2013

[雑誌論文] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer.

Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Kobata T, Matsuura B, Abe M, Onji M. 2013

[学会発表] IgG4 関連疾患診断における肝組織検査の有用性

徳本良雄,阿部雅則,多田藤政,畔元信明,熊木天児,日浅陽一,恩地森一 2013

[学会発表] Changes in the characteristics and prognosis of pancreatic cancer within the gemcitabine era and the issues facing elderly patients

Kuroda T,Kumagi T,Yokota T,Seike H,Miyaike J,Nishiyama M,Imai Y,Tatsukawa H,Shibata N,Koizumi M,Yamanishi H,Azemoto N,Abe M,Matsuura B,Hiasa Y,Onji M 2013

[雑誌論文] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer

Koizumi M, Hiasa Y, Kumagi T, et al. 2013

[雑誌論文] Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells.

Mori K, Yamanishi H, Ikeda Y, Kumagi T, Hiasa Y, Matsuura B, Abe M, Onji M. 2013

[雑誌論文] Body Mass Index as the Predictive Factor for the Onset of Nonalcoholic Fatty Liver Disease: A Community-based Retrospective Longitudinal Cohort Study.

Miyake T, Kumagi T, Hirooka M, Furukawa S, Koizumi M, Tokumoto Y, Ueda T, Yamamoto S, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M. 2013

[雑誌論文] Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus.

Furukawa S, Saito I, Yamamoto S, Miyake T, Ueda T, Niiya T, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Sakurai S, Matsuura B, Onji M, Tanigawa T. 2013

[学会発表] Changes in the characteristics and prognosis of pancreatic cancer within the gemcitabine era and the issues facing elderly patients

Kuroda T,Kumagi T,Yokota T,Seike H,Miyaike J,Nishiyama M,Imai Y,Tatsukawa H,Shibata N,Koizumi M,Yamanishi H,Azemoto N,Abe M,Matsuura B,Hiasa Y,Onji M. 2013

[雑誌論文] as the Ehime Pancreato-Cholangiology (EPOCH) Study Group. Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era : A collaborative retrospective multi- center clinical review of 1,082 patients

Kuroda T, Kumagi T, Yokota T, et al. 2013

[雑誌論文] Biliary atresia and survival into adulthood without transplantation: a collaborative multi-centre clinic review.

Kumagi T, Drenth JPH, Guttman O, Ng V, Lilly L, Therapondos G, Hiasa Y, Michitaka K, Onji M, Watanabe Y, Sen S, Griffiths W, Roberts E, Heathcote EJ, Hirschfield GM. 2012

[学会発表] 当科における膵癌stage IVb患者の予後を規定する因子の検討

畔元信明,熊木天児,山西浩文,黒田太良,小泉光仁,阿部雅則,松浦文三,日浅陽一,恩地森一 2012

[雑誌論文] Lymphotoxin β Receptor Signaling Promotes Development of Autoimmune Pancreatitis.

Seleznik GM, Reding T, Romrig F,…… Kumagi T, et al. 2012

[学会発表] Sleep-disordered breathing as a modifiable risk factor for microvascular complications in Japanese type 2 diabetes mellitus.

Furukawa S,Saito I,Miyake T,Ueda T,Niiya T,Kumagi T,Sakai T,Minami H,Miyaoka H,Matsuura B,Tanigawa T,Onji M 2012

[学会発表] Correlation between pancreatic blood flow on contrast-enhanced ultrasonography and fibrosis in chronic pancreatitis

Azemoto N,Kumagi T,Yokota T,Hirooka M,Kuroda T,Koizumi M,Yamanishi H,Abe M,Ikeda Y,Hiasa Y,Matsuura B,Onji M 2012

[学会発表] 愛媛県消化器内科における膵癌診療の実態

黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一,横田智行,清家裕貴,上原貴秀,今井祐輔,達川はるか,宇都宮大貴,西山麻里,稲田暢,芝田直純,今峰聡,岡田眞一 2012

[雑誌論文] High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon-Based Therapy for Hepatitis C Virus.

Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M. 2012

[学会発表] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease in Japanese: A Community-based Cross-sectional Study

Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M 2012

[学会発表] 超音波内視鏡検査にて詳細に観察し得た膵サルコイドーシスの1例

岩村文貴,畔元信明,熊木天児,黒田太良,小泉光仁,山西浩文,池田宜央,松浦文三,日浅陽一,恩地森一 2012

[雑誌論文] Regulatory Dendritic Cells Pulsed with Carbonic Anhydrase I Protect Mice from Colitis Induced by CD4+CD25− T Cells.

Yamanishi H, Murakami H, Ikeda Y, Kumagi T, Hiasa Y, Abe M, Matsuura B, Onji M. 2012

[学会発表] 剖検により診断された胆嚢印環細胞癌の1例

小田眞由,黒田太良,熊木天児,小泉光仁,山西浩文,畔元信明,廣岡昌史,阿部雅則,池田宜央,松浦文三,恩地森一,曽我美子 2012

[学会発表] 造影超音波検査による慢性膵炎病期診断の試み

畔元信明,熊木天児,黒田太良,小泉光仁,山西浩文,池田宜央,松浦文三,日浅陽一,恩地森一 2012

[学会発表] ダブルバルーン内視鏡にて診断された小腸腫瘍性病変の臨床的検討

池田宜央,布井弘明,壷内栄治,川﨑敬太郎,有光英治,竹治 智,渡辺崇夫,森健一郎,山本安則,小泉光仁,畔元信明,山西浩文,熊木天児,阿部雅則,日浅陽一,松浦文三,恩地森一 2012

[雑誌論文] An unusual case of subclinical diffuse glucagonoma coexisting with two nodules in the pancreas: characteristic features on computed tomography.

Azemoto N, Kumagi T, Yokota T, Kuroda T, Koizumi M, Yamanishi H, Soga Y, Furukawa S, Abe M, Ikeda Y, Hiasa Y, Matsuura B, Watanabe J, Kushihata F, Onji M. 2012

[学会発表] ペルフルブタンを用いた造影超音波検査による慢性膵炎病期診断の試み

畔元信明,熊木天児,恩地森一 2012

[学会発表] Clinical characteristics of diabetic patients beyond age of 85 in Japanese population

Matsuda T,Furukawa S,Yamamoto S,miyake T,Ueda T,Kumagi T,Niiya T,Minami H,Sakai T,Miyaoka H,Matsuura B,Onji M 2012

[学会発表] 横断調査に基づく超高齢者2型糖尿病の治療実態に関する検討

松田隼弥,古川慎哉,横本祐希,安部陽介,高木康平,垣生恭佑,熊木天児,日浅陽一,松浦文三,恩地森一 2012

[雑誌論文] Suicide attempt by an overdose of sitagliptin, an oral hypoglycemic agent: A case report and a review of the literature.

Furukawa S, Kumagi T, Miyake T, Ueda T, Niiya T, Nishino K, Murakami S, Murakami M, Matsuura B, Onji M. 2012

[学会発表] B cell activating factor is associated with the histological severity of nonalcoholic fatty liver disease

Miyake T,Furukawa S,Abe M,Kawasaki K,Tada F,Yamamoto S,Kumagi T,Hiasa Y,Matsuura B,Onji M 2012

[学会発表] The predictive factor for the onset of nonalcoholic fatty liver disease

Miyake T,Kumagi T,Furukawa S,Hirooka M,Koizumi M,Tokumoto Y,Yamamoto S,Abe M,Hiasa Y,Matsuura B,Onji M 2012

[雑誌論文] Natural history and management of primary biliary cirrhosis.

Al-Harthy N, Kumagi T 2012

[学会発表] There was a negative relationship between motilin and growth hormone secretagogue receptors.

Nunoi H,Matsuura B,Utsunomiya S,Ueda T,Miyake T,Furukawa S,Kumagi T,Ikeda Y,Abe M,Hiasa Y,Onji M 2012

[学会発表] ウルソデオキシコール酸に対する治療反応性による原発性胆汁性肝硬変の予後予測

畔元信明,熊木天児,阿部雅則,眞柴寿枝,日浅陽一,恩地森一 2012

[学会発表] Carbonic anhydrase I –specific therapeutic approach protect mice from CD4+CD25− T cell induced colitis.

Yamanishi H,Ikeda Y,Abe M,Kumagi T,Hiasa Y,Matsuura B,Onji M 2012

[雑誌論文] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease: A Community-based Cross-sectional Study.

Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M. 2012

[学会発表] 胆道閉鎖症に対する葛西術後,肝移植を施行されることなく成人に達した3例

熊木天児,小泉光仁,黒田太良,畔元信明,山西浩文 2012

[雑誌論文] Long-term Branched-chain Amino Acid Supplementation Improves Glucose Tolerance in Patients with Nonalcoholic Steatohepatitis-related Cirrhosis.

Miyake T, Abe M, Furukawa S, Tokumoto Y, Toshimitsu K, Ueda T, Yamamoto S, Hirooka M, Kumagi T, Hiasa Y, Matsuura B, Onji M. 2012

[雑誌論文] LymphotoxinβReceptor Signaling Promotes Development of Autoimmune Pancreatitis

Seleznik GM, Reding T, Kumagi T, et al. 2012

[学会発表] ERCPにて膵管狭窄像を認めなかったIgG4関連硬化性胆管炎の一例

小川泰司,長谷部昌,兼光 梢,村上貴俊,上原貴秀,中西征司,宮池次郎,大本昌樹,熊木天児,堀池典生,梅田政吉 2012

[学会発表] Therapeutic treatment of experimental colitis with regulatory dendritic cells pulsed with carbonic anhydrase I

Yamanishi H,Ikeda Y,Abe M,Kumagi T,Hiasa Y,Matsuura B,Onji M 2012

[学会発表] 当科における膵癌stageIVb患者の予後を規定する因子の検討

畔元信明,熊木天児,山西浩文,黒田太良,小泉光仁,阿部雅則,松浦文三,日浅陽一,恩地森一 2012

[学会発表] 愛媛県消化器内科における膵癌診療の実態

黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一,横田智行,清家裕貴,上原貴秀,今井祐輔,達川はるか,宇都宮大貴,西山麻里,稲田 暢,芝田直純,今峰 聡,岡田眞一 2012

[雑誌論文] A relationship between motilin and growth hormone secretagogue receptors.

Nunoi H, Matsuura B, Utsunomiya S, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M. 2012

[学会発表] Biochemical response to ursodeoxycholic acid predicts long-term outcome in Japanese patients with primary biliary cirrhosis: a validation study

Azemoto N, Kumagi T, Abe M, Konishi I, Matsuura B, Hiasa Y, Onji M 2011

[学会発表] 膵仮性嚢胞内の炎症が胃壁へ波及し穿破をきたした慢性膵炎の1例

宮本裕也,畔元信明,熊木天児,黒田太良,小泉光仁,山西浩文,池田宜央,松浦文三,日浅陽一,恩地森一 2011

[雑誌論文] Trancatheter arterial embolization with fine-powder cisplatin-lipiodol for HCC.

Koizumi Y, Hirooka M, Uehara T, Kisaka Y, Uesugi K, Kumagi T, Abe M, Matsuura B, Hiasa Y, Onji M. 2011

[学会発表] B cell-activating factor as a novel marker in autoimmune pancreatitis.

Kumagi T, Yamanishi H, Yokota T, Azemoto N, Koizumi M, Abe M,  Murakami H, Ikeda Y, Hiasa Y, Matsuura B, Kawamoto H, Yamamoto K, Onji M 2011

[学会発表] 当科における非B非C型肝癌の臨床的特徴の検討

廣岡昌史,平岡淳,日浅陽一,越智裕紀,小泉洋平,木阪吉保,阿部雅則,熊木天児,松浦文三,道堯浩二郎,恩地森一 2011

[学会発表] SNMCとグリチルリチン錠投与による偽性アルドステロン症および横紋筋融解症の

増田香奈,小泉洋平,石原 暢,越智裕紀,徳本良雄,眞柴寿枝,廣岡昌史,古川慎哉,熊木天児,阿部雅則,松浦文三,日浅陽一,恩地森一 2011

[学会発表] 自己免疫性膵炎における新規マーカーとしての血清中BAFF濃度の臨床的意義

熊木天児、山西浩文、河本博文 2011

[学会発表] C型肝炎ウイルスに対する細胞傷害性T細胞エピトープワクチン

眞柴寿枝,日浅陽一,徳本良雄,上杉和寛,重松秀一郎,多田藤政,廣岡昌史,阿部雅則,熊木天児,池田宜央,松浦文三,恩地森一 2011

[学会発表] 繰り返す肝性脳症に対して門脈大循環分流術が有用であった1例

石原暢,木阪吉保,徳本良雄,越智裕紀,小泉洋平,廣岡昌史,眞柴寿枝,阿部雅則,熊木天児,古川慎哉,松浦文三,日浅陽一,恩地森一 2011

[雑誌論文] Hepatocellular carcinoma in case of Wilson’s disease treated with radiofrequency ablation therapy.

Ikegawa S, Hiraoka A, Shimizu Y, Hidaka S, Tazuya N, Ichiryu M, Nakahara H, Tanabe A, Tanihira T, Hasebe A, Miyamoto Y, Ninomiya T, Hirooka M, Kumagi T, Abe M, Hiasa Y, Onji M, Michitaka K. 2011

[雑誌論文] Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port.

Koizumi Y, Hiraoka A, Michitaka K, Tazuya N, Ichiryu M, Nakahara H, Ochi H, Tanabe A, Hidaka S, Kodama A, Uehara T, Hasebe A, Miyamoto Y, Ninomiya T, Kumagi T, et al. 2011

[学会発表] B Cell-Activating Factor as a novel marker in Autoimmune Pancreatitis

Kumagi T,Yamanishi I,Yokota T,Azemoto N,Koizumi M,Kuroda T,Abe M,Ikeda Y,Hiasa Y, Matsuura B,Kawamoto H,Yamamoto K,Onji M. 2011

[学会発表] 胆管近接病変に対するGd-EOB-MRIによる仮想超音波支援下RFA

広岡昌史,越智裕紀,小泉洋平,畔元信明,木阪吉保,古川慎哉,阿部雅則,熊木天児,日浅陽一,恩地森一 2011

[雑誌論文] Characteristics of small-bowel tumors detected by double balloon endoscopy.

Imaoka H, Higaki N, Kumagi T*, Miyaike J, Ohmoto M, Yamauchi K, Murakami T, Murakami H, Ikeda Y, Yokota T, Shibata N, Ninomiya T, Abe M, Hiasa Y, Matsuura B, Onji M, Umeda M, Horiike N. 2011

[学会発表] 経皮的内視鏡的ネクロセクトミーにより救命し得た重症急性膵炎の1例

八鹿 潤,畔元信明,熊木天児,小泉光仁,山西浩文,阿部雅則,日浅陽一,恩地森一,横田智行 2011

[学会発表] Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells

Yamanishi H, Murakami H, Ikeda Y, Kumagi T, Hiasa Y, Abe M, Matsuura B, Onji M 2011

[雑誌論文] Ulcerative colitis complicated with primary biliary cirrhosis.

Tada F, Abe M, Nunoi H, Azemoto N, Mashiba T, Furukawa S, Kumagi T, Murakami H, Ikeda Y, Matsuura B, Hiasa Y, Onji M. 2011

[雑誌論文] Clinical significance of B Cell-Activating Factor in Autoimmune Pancreatitis.

Yamanishi H, Kumagi T, Yokota T, Azemoto N, Koizumi M, Kobayashi Y, Abe M, Murakami H, Hiasa Y, Matsuura B, Kawamoto H, Yamamoto K, Onji M. 2011

[学会発表] Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a

Ueda T, Matsuura B, Miyake T, Furukawa S, Kumagi T, Abe M, Hiasa Y,   Onji M 2011

[学会発表] 原発性胆汁性肝硬変において治療反応性および肝線維化の進行に寄与する因子

熊木天児、畔元信明、阿部雅則 2011

[雑誌論文] Biochemical response to ursodeoxycholic acid predicts long-term outcome in Japanese patients with primary biliary cirrhosis.

Azemoto N, Kumagi T*, Abe M, Konishi I, Matsuura B, Hiasa Y, Onji M. 2011

[学会発表] Characteristics of small-bowel tumors detected by double balloon endoscopy

Imaoka H, Higaki N, Kumagi T, Miyaike J, Ohmoto M, Yamauchi K, Murakami T, Murakami H, Ninomiya T, Ikeda Y, Yokota T, Shibata N, Abe M, Hiasa Y, Matsuura B, Onji M, Umeda M, Horiike N 2011

[雑誌論文] Epithelial Cyst Arising in an Intrapancreatic Accessory Spleen: A Diagnostic Dilemma.

Yamanishi H, Kumagi T*, Yokota T, Koizumi M, Azemoto N, Watanabe J, Mizuno Y, Sugita A, Abe M, Ikeda Y, Matsuura B, Hiasa Y, Onji M. 2011

[学会発表] カラードプラ超音波が有用であった右肝動脈仮性動脈瘤の一例

黒田太良,畔元信明,小泉光仁,山西浩文,熊木天児,廣岡昌史,阿部雅則,池田宜央,松浦文三,恩地森一

[学会発表] 高齢者原発性胆汁性肝硬変における肝細胞癌合併に関する臨床背景の検討

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