細菌分子によるマトリックス・アンカーリングの機構解明と実用化を目指した前臨床研究

トップ›研究者を探す›細菌分子によるマトリックス・アンカーリングの機構解明と実用化を目指した前臨床研究

細菌分子によるマトリックス・アンカーリングの機構解明と実用化を目指した前臨床研究

代表研究者	松下治
研究課題番号	KAKENHI-PROJECT-23590516
研究種目	基盤研究(C)
研究分野	生物系医歯薬学基礎医学細菌学(含真菌学)
研究機関	岡山大学北里大学
研究分担者	安達栄治郎
研究分担者	井上浄
研究分担者	森望
研究分担者	内田健太郎
連携研究者	美間健彦
連携研究者	宮下武憲
研究期間開始年月日	2011/4/1
研究期間終了年度	2013
研究ステータス	完了 (2013/4/1)
配分額（合計）	5,330,000 (直接経費 :4,100,000、間接経費 :1,230,000)
配分額（履歴）	2013年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2012年度：1,300,000 (直接経費 :1,000,000、間接経費 :300,000) 2011年度：2,730,000 (直接経費 :2,100,000、間接経費 :630,000)
キーワード	細菌毒素コラーゲン結合ドメイン細胞外マトリックス膠原線維アンカーリング骨新生再生医療技術移転アンカーリンク PKDドメイン

研究成果

[雑誌論文] Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines

Fukata Y, Itoh A, Nonaka Y, Ogawa T, Nakamura T, Matsushita O, Nishi N. 2014

[雑誌論文] Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model

Katikaneni R, Ponnapakkam T, MatsushitaO, Sakon J, Gensure R 2014

[雑誌論文] Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase.

Uchida K, Matsushita O, Naruse K, Mima T, Nishi N, Hattori S, Ogura T, Inoue G, Tanaka K, Takaso M. 2014

[学会発表] Drug delivery based on clostridial collagenase showed therapeutic effects in orthopedic surgery

松下治、美間健彦、山本由弥子、鈴木智典、横田憲二 2014

[学会発表] Drug delivery based on clostridial collagenase showed therapeutic effects in orthopedic surgery

松下　治、美間健彦、山本由弥子、鈴木智典、横田憲治 2014

[雑誌論文] Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines.

Fukata Y, Itoh A, Nonaka Y, Ogawa T, Nakamura T, Matsushita O, Nishi N. 2014

[雑誌論文] Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum.

Bauer R, Wilson JJ, Philominathan ST, Davis D, Matsushita O, Sakon J. 2013

[学会発表] Structural comparison od collagen- binding domains derived from Clostridium histolyticum collagenases

松下治、美間健彦、山本由弥子、鈴木智典、横田憲二 2013

[雑誌論文] Effects of CB-VEGF-A Injection in Rat Flap Models for Improved Survival.

Akimoto M, Takeda A, Matsushita O, Inoue J, Sakamoto K, Hattori M, Kounoike N, Uchinuma E. 2013

[雑誌論文] Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

Saito W, Uchida K, Ueno M, MatsushitaO, Inoue G, Nishi N, Ogura T, Hattori S, Fujimaki H, Tanaka K, Takaso M 2013

[学会発表] Bacterial collagen-binding domains - Molecular basics and clinical applications

Osamu Matsushita, Takehiko Mima, Eijiro Adachi, Joshua Sakon, Nozomu Nishi, Takenori Miyashita, Nozomu Mori, Joe Inou1, Masakazu Hattori, Minekatsu Akimoto, Akira Takeda, Eiju Uchinuma 2012

[学会発表] Bacterial collagen-binding domains - Molecular basics and clinical applications

Osamu Matsushita, Takehiko Mima, Eijiro Adachi, Joshua Sakon, Nozomu Nishi, Takenori Miyashita, NozomuMori, JoeInoue, Masakazu Hattori, Minekatsu Akimoto, Akira Takeda, Eiju Uchinuma 2012

[雑誌論文] A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice.

Ponnapakkam T, Katikaneni R, Suda H, Miyata S, Matsushita O, Sakon J, Gensure RC. 2012

[雑誌論文] Bacterial collagen-binding domain targets undertwisted regions of collagen.

Philominathan ST, Koide T, Matsushita O, Sakon J. 2012

[学会発表] ガス壊疽菌群コラゲナーゼの基質認識機構の解明と臨床応用

松下治、美間健彦、鈴木智典、山本由弥子、横田憲治、小出隆規、安達栄治郎、玉井栄治、宮田茂、南純三朗、岡部昭延 2012

[雑誌論文] Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

Katikaneni R, Ponnapakkam T, Suda H, Miyata S, Sakon J, MatsushitaO, Gensure RC 2012

[雑誌論文] Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS

Sides CR, Liyanage R, Lay JO Jr, Philominathan ST, Matsushita O, Sakon J 2012

[学会発表] 細菌性コラゲナーゼの基質認識と臨床応用

松下治 2012

[学会発表] 細菌性コラゲナーゼの基質認識と臨床応用

松下治 2012

[雑誌論文] Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain.

Katikaneni R, Ponnapakkam T, Suda H, Miyata S, Sakon J, Matsushita O, Gensure RC. 2012

[雑誌論文] Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone.

Ponnapakkam T, Katikaneni R, Nichols T, Tobin G, Sakon J, Matsushita O, Gensure RC. 2011

[雑誌論文] Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone

Ponnapakkam T, Katikaneni R, Nichols T, Tobin G, Sakon J, Matsushita O, Gensure RC 2011