トップ›研究者を探す›化学的ストレスによる細胞死に於ける亜鉛イオンの毒性科学的役割について

化学的ストレスによる細胞死に於ける亜鉛イオンの毒性科学的役割について

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23510078
研究種目 基盤研究(C)
研究分野 総合・新領域系
複合新領域
環境学
放射線・化学物質影響科学
研究機関 徳島大学
代表研究者 小山 保夫
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額（合計） 2,600,000 (直接経費 :2,000,000、間接経費 :600,000)
配分額（履歴） 2013年度：650,000 (直接経費 :500,000、間接経費 :150,000)
2012年度：910,000 (直接経費 :700,000、間接経費 :210,000)
2011年度：1,040,000 (直接経費 :800,000、間接経費 :240,000)
キーワード 細胞毒性
亜鉛イオン
亜鉛
国際情報交換
酸化ストレス

研究成果

[雑誌論文] Effects of tetracaine and lidocaine on intracellular Zn^<2+> levels in rat neurons : Preliminary analysis with FluoZin-3 fluorescence

Eri Fukunaga, Yasuo Oyama 2014

[雑誌論文] Clioquinol, a lipophilic Zn^<2+> chelator, augments and attenuates the cytotoxicity of H_2O_2: A bell-shaped response curve of the effects of the drug

Tomohiro M. Oyama, Keisuke Oyama, Eri Fukunaga, Hitoshi Ishibashi, Yasuo Oyama 2014

[雑誌論文] Triclocarban-induced change in intracellular Ca^<2+> level in rat thymocytes : Cytometric analysis with Fluo-3 under Zn^<2+>-free conditions

Yukari Miura, Xiaohui Chen, Saki Yamada, Aya Sugihara, Molomjamts Enkhjargal, Yuanzhi Sun, Keiko Kuroda, Masaya Satoh, Yasuo Oyama 2014

[雑誌論文] Clioquinol, a lipophilic Zn2+ chelator, augments and attenuates the cytotoxicity of H2O2: A bell-shaped response curve of the effects of the drug,

Tomohiro Oyama, Keisuke Oyama, Eri Fukunaga, Hitoshi Ishibashi and Yasuo Oyama 2014

[雑誌論文] Triclocarban-induced change in intracellular Ca2+ level in rat thymocytes: Cytometric analysis with Fluo-3 under Zn2+-free conditions.

Yukari Miura, Xiaohui Chen, Saki Yamada, Aya Sugihara, Molomjamts Enkhjargal, Yuanzhi Sun, Keiko Kuroda, Masaya Satoh and Yasuo Oyama 2014

[雑誌論文] Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress

Yasuhiro Kanbara, Kazuhiro Murakane, Yumiko Nishimura, Masaya Satoh, Yasuo Oyama 2013

[雑誌論文] Effect of triclocarban on membrane potential of rat thymocytes: Assessment with bis-(1,3-dibutylbarbituric acid)trimethine oxonol

Yuanzhi Sun, Molomjamts Enkhjargal, Aya Sugihara, Saki Yamada, Xiaohui Chen, Yukari Miura, Eri Fukunaga, Masaya Satoh and Yasuo Oyama 2013

[雑誌論文] Synergistic increase in cell lethality by dieldrin and H2O2 in rat thymocytes: Effect of dieldrin on the cells exposed to oxidative stress.

Tsolmon Chimeddorj, Tomoko Suzuki, Kazuhiro Murakane, Miyuki Inai, Masaya Satoh and Yasuo Oyama 2013

[雑誌論文] Effect of triclocarban on membrane potential of rat thymocytes : Assessment with bis-(1,3-dibutylbarbituric acid) trimethine oxonol

Yuanzhi Sun, Molomjamts Enkhjargal, Aya Sugihara, Saki Yamada, Xiaohui Chen, Yukari Miura, Eri Fukunaga, Masaya Satoh, Yasuo Oyama 2013

[雑誌論文] Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress

Yasuhiro Kanbara, Kazuhiro Murakane, Yumiko Nishimura, Masaya Satoh and Yasuo Oyama 2013

[雑誌論文] Role of Zn2+ in restoration of nonprotein thiol content in the cells under chemical stress induced by triclocarban

Eri Fukunaga, Yasuhiro Kanbara, Yumi Hirao and Yasuo Oyama 2013

[雑誌論文] Role of Zn^<2+> in restoration of nonprotein thiol content in the cells under chemical stress induced by triclocarban

Eri Fukunaga, Yasuhiro Kanbara, Yumi Hirao, Yasuo Oyama 2013

[雑誌論文] Decrease in intracellular Zn^<2+> level by propranolol : A model experiment using rat thymocytes

Yasuhiro Kanbara, Hakaru Seo, Yumiko Nishimura, Yasuo Oyama 2012

[雑誌論文] Nanomolar concentrations of zinc pyrithione increase cell susceptibility to oxidative stress induced by hydrogen peroxide in rat thymocytes

Tomohiro Oyama, Minoru Saito, Takayasu Yonezawa, Okano Yoshiro, Yasuo Oyama 2012

[雑誌論文] A comaprison of the cellular actions of polaprezinc (zinc-L-carnosine) and ZnCl2

Hakaru Seo et al. 2012

[雑誌論文] Further analysis on lidocaine-induced increase in intracellular Zn2+ concentration: Cytometric model study using FlioZin-3, 5-chloromethylfluorescein, and rat thymocytes

Yumiko Nishimura and Yasuo Oyama 2012

[雑誌論文] Triclosan, an antibacterial agent, increases intracellular Zn^<2+> concentration in rat thymocytes : Its relation to oxidative stress

Ikumi Tamura, Yasuhiro Kanbara, Minoru Saito, Kanna Horimono, Masaya Satoh, Hiroshi Yamamoto, Yasuo Oyama 2012

[雑誌論文] Clioquinol-induced increase and decrease in the intracellular Zn2+ level in rat thymocytes

Tomohiro Oyama et al. 2012

[雑誌論文] Elevation of intarcellular Zn2+ level by nanomolar concentrations of triclocarban in rat thymocytes

Junpei Morita et al. 2012

[雑誌論文] Yttrium decreases the intracellular Zn^<2+> concentration in rat thymocytes by attenuating a temperature-sensitive Zn^<2+> influx

Yusuke Takahashi, Kaori Kanemaru, Shoji Imai, Norikazu Miyoshi, Takuya Kawanai, Yasuo Oyama 2012

[雑誌論文] Further analysis on lidocaine-induced increase in intracellular Zn^<2+> concentration : Cytometric model study using FluoZin-3, 5-chloromethylfluorescein, and rat thymocytes

Yumiko Nishimura, Yasuo Oyama 2012

[雑誌論文] Yttrium decreases the intracellular Zn2+ concentration in rat thymocytes by attenuating a temperature-sensitive Zn2L influx

Yusuke Takahashi et al. 2012

[雑誌論文] Nanomolar concentrations of zinc pyrithione increase cell susceptability to oxidative stress induced by hydrogen peroxide in rat thymocytes

Tomohiro Oyama et al. 2012

[雑誌論文] NOR-3, a donor of nitric oxide, increases intracellular Zn^<2+> concentration and decreases cellular thiol content : A model experiment using rat thymocytes, FluoZin-3, and 5-chloromethylfluorescein

Soya Harada, Chiharu Kubota, Natsuho Kitano, Takuya Kawanai, Kazuki Koizumi, Yasuo Oyama, Akio Kinazaki, Shiro Ishida and Yoshiro Okano 2011

[雑誌論文] Putative role of intracellular Zn^<2+> release during oxidative stress : A trigger to restore cellular thiol content that is decreased by oxidative stress

Akio Kinazaki, Hongqin Chen, Kazuki Koizumi, Takuya Kawanai, Tomohiro Oyama, Masaya Satoh, Shiro Ishida, Yoshiro Okano, Yasuo Oyama 2011

[雑誌論文] Zinc-pyrithione exerts diverse actions on human leukemia K562 cells : A preliminary study on hormetic action

Yosuke Endo, Zhehao Han, Jun Kurochi, Masahiro Sakata, Akinori Maetaka, Takayasu Yonezawa, Kazuki Koizumi, Yasuo Oyama 2011

[雑誌論文] Elevation of intracellular Ca^<2+> level by triclosan in rat thymic lymphocytes : Increase in membrane Ca^<2+> permeability and induction of intracellular Ca^<2+> release

Ikumi Tamura, Minoru Saito, Yumiko Nishimura, Masaya Satoh, Hiroshi Yamamoto and Yasuo Oyama 2011

[雑誌論文] Tetracaine decreases intracellular Zn^<2+> concentration by inhibiting Zn^<2+> influx in rat thymocytes

Kaori Kimura, Yumiko Nishimura, Keisuke Oyama, Takuya Kawanai, Erika Hashimoto, Yasuo Oyama 2011

[雑誌論文] Some characteristics of membrane Cd^<2+> transport in rat thymocytes: An analysis using Fluo-3

Takuya Kawanai, Masahiro Fujinaga, Kazuki Koizumi, Isao Kurotani, Erika Hashimoto, Masaya Satoh, Shoji Imai, Norikazu Miyoshi, Yasuo Oyama 2011