トップ研究者を探す加齢グラフト部分肝移植における機能不全の解明と新たな治療法の開発

加齢グラフト部分肝移植における機能不全の解明と新たな治療法の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-23390324
研究種目 基盤研究(B)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 徳島大学
代表研究者 島田 光生
研究分担者 安友 康二
研究分担者 田中 真司
研究分担者 居村 暁
研究分担者 森根 裕二
研究分担者 武田 英二
研究分担者 宇都宮 徹
研究分担者 池本 哲也
研究分担者 片桐 豊雅
研究分担者 親泊 政一
研究期間 開始年月日 2011/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 18,980,000 (直接経費 :14,600,000、間接経費 :4,380,000)
配分額(履歴) 2013年度:5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
2012年度:6,110,000 (直接経費 :4,700,000、間接経費 :1,410,000)
2011年度:7,670,000 (直接経費 :5,900,000、間接経費 :1,770,000)
キーワード 肝不全
加齢肝
幹細胞
加齢遺伝子
マイクロダイアライシス

研究成果

[雑誌論文] Recent advances in estimating hepatic functional reserve in patients with chronic liver damage.

Imura S, Shimada M, Utsunomiya T. 2015

[雑誌論文] Gene profile in the spleen under massive partial hepatectomy using complementary DNA microarray and pathway analysis.

Arakawa Y1, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Kanamoto M, Iwahashi S, Saito Y, Takasu C. 2014

[雑誌論文] A hydrolyzed whey peptide-based diet ameliorates hepatic ischemia-reperfusion injury in the rat nonalcoholic fatty liver.

Nii A , Utsunomiya T, Shimada M, Ikegami T, Ishibashi H, Imura S, Morine Y, Ikemoto T, Sasaki H, Kawashima A. 2014

[雑誌論文] Senescence-related genes may be responsible for poor liver regeneration after hepatectomy in elderly patients.

Zhu C, Ikemoto T, Utsunomiya T, Yamada S, Morine Y, Imura S, Arakawa Y, Takasu C, Ishikawa D, Shimada M. 2014

[雑誌論文] G Beneficial effects of enteral nutrition containing with hydrolyzed whey peptide on warm ischemia/reperfusion injury in the rat liver.

Hanaoka J, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Sugimoto K, Saito Y, Yamada S, Asanoma M 2014

[雑誌論文] A hydrolyzed whey peptide-based diet ameliorates hepatic ischemia-reperfusion injury in the rat nonalcoholic fatty liver

Nii A, Utsunomiya T, Shimada M, Ikegami T, Ishibashi H, Imura S, Morine Y, Ikemoto T, Sasaki H, Kawashima A 2014

[雑誌論文] Bevacizumab Improves Splenomegaly and Decreases Production of Hyaluronic Acid After L-OHP Based Chemotherapy.

Arakawa Y, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Hanaoka J, Kanamoto M, Iwahashi S, Saito Y, Yamada S, Asanoma M, Takasu C, Bando Y. 2014

[雑誌論文] Beneficial effects of green tea catechin on massive hepatectomy model in rats.

Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M. 2014

[雑誌論文] Effects of a whey peptide-based enteral formula diet on liver dysfunction following living donor liver transplantation

Arakawa Y, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Hanaoka J 2014

[雑誌論文] Beneficial effects of green tea catechin on massive hepatectomy model in rats.

Saito Y, Mori H, Takasu C, Komatsu M, Hanaoka J, Yamada S, Asanoma M, Ikemoto T, Imura S, Morine Y, Utsunomiya T, Shimada M. 2014

[雑誌論文] Trophic effect of adipose tissue-derived stem cells on porcine islet cells.

Yamada S, Shimada M, Utsunomiya T, Ikemoto T, Saito Y, Morine Y, Imura S, Mori H, Arakawa Y, Kanamoto M, Iwahashi S. 2014

[雑誌論文] Cytokine expression in spleen affects progression of liver cirrhosis through liver-spleen cross-talk.

Asanoma M1, Ikemoto T, Mori H, Utsunomiya T, Imura S, Morine Y, Iwahashi S, Saito Y, Yamada S, Shimada M. 2014

[雑誌論文] Preand postoperative nutritional assessment and health-related quality of life in recipients of living donor liver transplantation

Urano E, Yamanaka-Okumura H, Teramoto A, Sugihara K, Morine Y, Imura S, Utsunomiya T, Shimada M, Takeda E 2014

[雑誌論文] Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection.

Sugihara K, Yamanaka-Okumura H, Teramoto A, Urano E, Katayama T, Mori H, Utsunomiya T, Shimada M, Takeda E. 2014

[雑誌論文] Effect of TU-100, a traditional Japanese medicine, administered after hepatic resection in patients with liver cancer: a multi-center, phase III trial (JFMC40-1001).

Shimada M , Morine Y, Nagano H, Hatano E, Kaiho T, Miyazaki M, Kono T, Kamiyama T, Morita S, Sakamoto J, Kusano M, Saji S, Kanematsu T, Kitajima M. 2014

[雑誌論文] Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells.

Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K. 2014

[雑誌論文] Improving allogeneic islet transplantation by suppressing Th17 and enhancing Treg with histone deacetylase inhibitors.

Sugimoto K, Itoh T, Takita M, Shimoda M, Chujo D, SoRelle JA, Naziruddin B, Levy MF, Shimada M, Matsumoto S. 2014

[雑誌論文] Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis

Utsunomiya T, Shimada M, Morine Y, Tajima A, Imoto I 2014

[雑誌論文] CXC receptor 4 and stromal cell-derived factor 1 in primary tumors and liver metastases of colorectal cancer

Yamada S, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Mori H, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y 2014

[雑誌論文] Laparoscopic hepatic resection for metastatic liver tumor of colorectal cancer : comparative analysis of short- and long-term results

Iwahashi S, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Arakawa Y, Mori H, Kanamoto M, Yamada S. 2014

[雑誌論文] Effects of splenectomy on hepatic gene expression profiles after massive hepatectomy in rats.

Arakawa Y , Shimada M, Utsunomya T, Imura S, Morine Y, Ikemoto T, Takasu C. 2013

[学会発表] The gene profile in the spleen under rat small-for-size graft model using cDNA microarray and pathway analaysis

Arakawa Y , Shimada M, Ishikawa D, Y amada S, Saito Y , T akasu C, Iwahashi S, Kanamoto M, Mori H, Ikemoto T , Morine Y , Imura S, Utsunomiya T , Sato H, Miyake H 2013

[学会発表] Successful management of liver transplant recipient with strongly positive donor-specific antibody against human leukocyte antigen

Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S 2013

[学会発表] The homing effect of adipose-derived stem cells to the injured liver : The shift of stromal cellderived factor 1 expressions

Saito Y , Shimada M, Utsunomiya T , Ikemoto T , Y amada S, T akasu C. 2013

[学会発表] Bevacizumabの小胞体ストレス応答を介した肝切除後肝機能障害改善・肝再生促進効果

矢田圭吾, 島田光生, 宇都宮徹, 石橋広樹, 佐藤宏彦, 居村暁, 森根裕二, 池本哲也, 森大樹, 荒川悠佑, 金本真美, 2013

[学会発表] ラットsmall-for-size graft modelにおける脾臓内遺伝子発現の変化Ingenuity Pathway Analysisを用いた検討

荒川悠佑, 島田光生, 石川大地, 山田眞一郎, 齋藤裕, 髙須千絵, 岩橋衆一, 金本真美, 池本哲也, 居村暁, 森根裕二, 宇都宮徹 2013

[学会発表] 脂肪由来幹細胞の傷害肝へのホーミング効果 -癌幹細胞転移メカニズムへの応用-

齋藤裕, 島田光生, 宇都宮徹, 池本哲也, 山田眞一郎, 森根裕二, 居村暁, 森大樹, 荒川悠佑, 金本真美, 岩橋衆一, 髙須千絵, 2013

[学会発表] Whey protein含有高機能流動食を用いた周術期栄養療法の有用性

金本真美, 島田光生, 宇都宮徹, 佐藤宏彦, 森根裕二, 居村暁, 池本哲也, 森大樹, 岩橋衆一, 齋藤裕, 山田眞一郎, 淺野間理仁, 2013

[学会発表] 高齢者の肝再生不全の機序解明と治療への応用

荒川悠佑, 島田光生, 石川大地, 山田眞一郎, 淺野間理仁, 齋藤裕, 岩橋衆一, 金本真美, 森大樹, 池本哲也, 森根裕二, 居村暁, 2013

[学会発表] ヒト脂肪由来幹細胞による肝傷害軽減効果に関する基礎的検討

齋藤裕, 島田光生, 宇都宮徹, 池本哲也, 山田眞一郎, 石川大地, 岩橋衆一, 金本真美, 荒川悠佑, 森大樹, 森根裕二, 居村暁 2013

[学会発表] 高齢ドナー肝再生不全と加齢指標マーカーについての検討

荒川悠佑, 島田光生, 石川大地, 山田眞一郎, 淺野間理仁, 齋藤裕, 岩橋衆一, 金本真美, 池本哲也, 森根裕二, 居村暁, 宇都宮徹 2013

[学会発表] Recent Advancements in Liver Surgery : Assessment of Funcional Reserve, Simulation and Navigation

Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Arakawa Y , Kanamoto M, Iwahashi S, Saito Y , T akasu C, Y amada S 2013

[学会発表] 脂肪由来幹細胞を用いた肝胆膵領域の再生医療に関するimpactと課題

池本哲也 島田光生, 宇都宮徹, 居村暁, 森根裕二, 森大樹, 荒川悠佑, 金本真美, 齋藤裕, 山田眞一郎, 淺野間理仁, 三宅秀則 2013

[学会発表] Impact of human adipose tissue derived regenerative cell for cryopreserved porcine islets

Ikemoto T, Shimada M, Utsunomiya T, Imura S, Morine Y, Hanaoka J, Miyatani T , Kanamoto M 2012

[雑誌論文] Outcome of hepatectomy in super-elderly patients with hepatocellular carcinoma.

Yamada S, Shimada M, Utsunomiya T, et al. 2012

[雑誌論文] Impact of a new refrigerator for the preservation of whole blood

Kanamoto M, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J 2012

[学会発表] Enkhbold Chinbold. One-Stop Shopping for 3-Dimensional Anatomy of Hepatic V asculature and Bile Duct with a Special Reference to Biliary Image Reconstruction

Shimada M, Utsunomiya T , Imura S, Morine Y, Ikemoto T, Hanaoka J, Miyatani T , Saito Y , Yamada S 2012

[雑誌論文] Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve

Utsunomiya T, Shimada M, Hanaoka J, Kanamoto M, Ikemoto T, Morine Y, Imura S, Harada M 2012

[学会発表] ヒト脂肪由来幹細胞を用いた障害臓器修復に関する研究

池本 哲也 他 2012

[雑誌論文] Impact of a new refrigerator on the preservation of hepatic grafts

Kanamoto M, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J 2012

[雑誌論文] Impact of a new refrigerator on the preservation of hepatic grafts

Kanamoto M, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J 2012

[学会発表] The possibility of adipose-derived regenerative cells for an alternative therapy for liver failure

Mori H, Shimada M, Saito Y , Utsunomiya T , Imura S, Morine Y , Ikemoto T , Hanaoka J, Iwahashi S, Asanoma M, Y amada S 2011

[学会発表] Whey protein isolate, MEIN[〇!R], can reduce liver damege early after living donor liver transplantation

Ishikawa D, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, Iwahashi S, Saito Y , Asanoma M, Kume H, Sasaki H 2011

[学会発表] Cytoprotective effect of human adipose tissue derived stem cell on porcine islet cells

Yamada S, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, Iwahashi S, Saito Y , Asanoma M 2011

[学会発表] Ischemia reperfusion injury enhances SDF1 expressions and homing of adipose derived regenerative cells in the liver

Saito Y , Shimada M, Utsunomiya T , Morine Y, Imura S, Ikemoto T, Mori H, Hanaoka J, Sugimoto K, Y amada S, Asanoma M 2011

[学会発表] Regeneration of caudate lobe in extended left lobe graft including caudate lobe after living donor liver transplantation

Shimada M, Imura S, Mori H, Morine Y, Ikemoto T, Hanaoka J, Kanamoto M, Iwahashi S, Saito Y , Asanoma M, Y amada S, Utsunomiya T 2011

[学会発表] Green T ea Catechins Improve Liver Dysfunction Following Massive Hepatectomy Through Anti-Oxidative and Anti-Inflammatory Activities in Rat

Saito Y , Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Hanaoka J, Kanamoto M 2011

[学会発表] The possibility of adipose-derived stem cells for an alternative therapy for liver failure

Saito Y , Shimada M, Utsunomiya T, Ikemoto T, Yamada S, Morine Y, Imura S, Mori H, Hanaoka J, Sugimoto K, Asanoma M 2011

[学会発表] Bevacizumab ameliorates sinusoidal injury after oxaliplatin-based chemotherapy and enhances liver regeneration after hepatectomy

Hanaoka J, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Mori H, Saito Y , Y amada S, Asanoma M 2011

[雑誌論文] Beneficial effects of follistatin in hepatic ischemia-reperfusion injuries in rats

Kanamoto M, Shimada M, Morine Y, Yoshizumi T, Imura S, Ikegami T, Mori H, Arakawa Y 2011

[雑誌論文] Role of UCP2 expression after hepatic warm ischemia-reperfusion in the rat

Ninomiya M, Shirabe K, Shimada M, Terashi T, Maehara Y 2011