獲得免疫システムを特徴づける胸腺微小環境の分子基盤

トップ›研究者を探す›獲得免疫システムを特徴づける胸腺微小環境の分子基盤

代表研究者	高濱洋介
研究課題番号	KAKENHI-PROJECT-23249025
研究種目	基盤研究(A)
研究分野	生物系医歯薬学基礎医学免疫学
研究機関	徳島大学
研究分担者	高田健介
連携研究者	大東いずみ
研究期間開始年月日	2011/4/1
研究期間終了年度	2014
研究ステータス	完了 (2014/4/1)
配分額（合計）	47,970,000 (直接経費 :36,900,000、間接経費 :11,070,000)
配分額（履歴）	2014年度：11,700,000 (直接経費 :9,000,000、間接経費 :2,700,000) 2013年度：11,700,000 (直接経費 :9,000,000、間接経費 :2,700,000) 2012年度：11,700,000 (直接経費 :9,000,000、間接経費 :2,700,000) 2011年度：12,870,000 (直接経費 :9,900,000、間接経費 :2,970,000)
キーワード	獲得免疫 Tリンパ球胸腺レパトア形成胸腺上皮細胞 Tリンパ球レパトア形成胸腺微小環境

研究成果

[学会発表] 胸腺上皮細胞におけるミトコンドリアの役割

金　鳳柱、大東　いずみ、高浜　洋介 2015

[雑誌論文] Positive selection-inducing self-peptides displayed by cortical thymic epithelial cells.

Takada K, Takahama Y. 2015

[学会発表] Positive selection conditions TCR responsiveness in T cells

Yousuke Takahama 2015

[学会発表] 胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究：ノックアウトマウスと特異的抗体の作製によるアプローチ

近藤博之、大東いずみ、高浜洋介 2014

[学会発表] Role of mitochondria in thymic epithelial cells

KIM Bongju, OHIGASHI Izumi, TAKAHAMA Yousuke 2014

[雑誌論文] Increased number of Hassall's corpuscles in myasthenia gravis patients carrying thymic hyperplasia.

Matsui N, Ohigashi I, Tanaka K, Sakata M, Furukawa T, Nakagawa Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R 2014

[学会発表] mTECs derived from embryonic and postnatal beta5t+ progenitors

Izumi Ohigashi, Saulius Zuklys, Georg Hollander, Yousuke Takahama 2014

[雑誌論文] Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.

Williams JA, Zhang J, Jeon H, Nitta T, Ohigashi I, Klug D, Kruhlak MJ, Choudhury B, Sharrow SO, Granger L, Adams A, Eckhaus MA, Jenkinson SR, Richie ER, Gress RE, Takahama Y, Hodes RJ. 2014

[学会発表] Defective T cell tolerance in CCL21 knockout mice

KOZAI Mina, OHIGASHI Izumi, TAKAHAMA Yousuke 2014

[学会発表] 髄質上皮細胞の維持と再生におけるβ5t陽性前駆細胞の寄与

大東いずみ、高浜洋介 2014

[雑誌論文] Serial progression of cortical and medullary thymic epithelial microenvironments.

Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE. 2014

[雑誌論文] CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.

Ohigashi I, Takahama Y. 2014

[学会発表] β5t+ progenitors contribute to the maintenance and regeneration of medullary thymic epithelial cells

OHIGASHI Izumi, TAKAHAMA Yousuke 2014

[雑誌論文] Development and function of thymic cortical epithelial cells.

Takada K, Ohigashi I, Kasai M, Nakase H, Takahama Y. 2014

[学会発表] Seeking transcriptional mechanisms for regulation of β5t expression

Myn UDDIN, Izumi OHIGASHI, Yousuke TAKAHAMA 2014

[学会発表] 正の選択を介して決定されるCD8T細胞の抗原応答性

高田健介、高浜洋介 2014

[学会発表] Thymus microenvironment for the formation of CD8 T cell repertoire

Yousuke TAKAHAMA 2014

[学会発表] Thymoproteasome-dependent positive selection conditions antigen responsiveness of CD8 T cells

TAKADA Kensuke, TAKAHAMA Yousuke 2014

[学会発表] 胸腺プロテアソーム依存的に産生される自己ペプチドの正の選択における特性

高田健介、Le Ngoc Nhi、佐々木克博、村田茂穂、高浜洋介 2014

[学会発表] Positive selection conditions antigen responsiveness of CD8 T cells

Kensuke Takada and Yousuke Takahama 2014

[雑誌論文] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.

Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. 2014

[学会発表] Thymoproteasome-dependent MHC class I-associated peptide motifs contribute to positive selection of CD8 T cells

Kensuke Takada and Yousuke Takahama 2014

[雑誌論文] Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse

Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y. 2014

[雑誌論文] Serial progression of cortical and medullary thymic epithelial microenvironments

Alves NL, Takahama Y, Ohigashi I, Ribeiro AR, Baik S, Anderson G, Jenkinson WE. 2014

[雑誌論文] Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia

Matsui N, Ohigashi I, Tanaka K, Nagayama Y, Kondo K, Kitagawa T, Yamashita S, Nomura Y, Takahama Y, Kaji R. 2014

[雑誌論文] TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak MJ, Zuklys S, Sharrow SO, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander G, Takahama Y, Hodes RJ. 2013

[雑誌論文] Lymphotoxin beta receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells

Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y. 2013

[雑誌論文] The development of T lymphocytes in fetal thymus organ culture

Nitta T, Ohigashi I, Takahama Y. 2013

[雑誌論文] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling

Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield M, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S. 2013

[雑誌論文] Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus

Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, Manley NR. 2013

[雑誌論文] Thymic nurse cells provide microenvironment for secondary TCRα rearrangement in cortical thymocytes

Nakagawa Y 2012

[学会発表] Thymic microenvironment and repertoire selection of T cells

Yousuke Takahama 2012

[学会発表] T lymphocyte repertoire formation in thymic micrpenvironments

Yousuke Takahama 2012

[学会発表] 免疫不全を呈するヒトCD3εトランスジェニックマウス系統tgε26におけるトランスジーン挿入部位の同定

Izumi Ohigashi 2011

[学会発表] Molecular Biology of Thymic Microenvironments

Yousuke Takahama 2011

[学会発表] Chemokine regulation of central tolerance

Yousuke Takahama 2011

[学会発表] 胸腺の機能

高浜洋介 2011

[学会発表] Cytokine circuit that regulates T cell repertoire formation

Yousuke Takahama 2011

[学会発表] 中枢性免疫寛容と自己免疫疾患

高浜洋介 2011

[学会発表] 胸腺皮質上皮細胞特異的β5t および髄質上皮細胞に発現するCCL21aの発現トレーサー実験による胸腺上皮細胞分化機構の解析

大東いずみ

[学会発表] Development and developmental potential of β 5t-expressing thymic epithelial cells

Ohigashi Izumi

[学会発表] 胸腺皮質上皮細胞特異的β5t遺伝子座にCreをノックインしたマウスの作製

大東いずみ

[学会発表] Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific β5t-Cre knock-in mice

OHIGASHI Izumi

[学会発表] Development and developmental potential of β5t-expressing thymic epithelial cells

Izumi Ohigashi

[学会発表] Thymus micro environments for T cell repertoire formation

Yousuke Takahama

[学会発表] Thymic cortical epithelial cells for T cell repertoire formation

Yousuke Takahama

[学会発表] T cell repertoire formation in the thymus

Yousuke Takahama

[学会発表] Serial development of cortical and medullary thymic epithelia

Yousuke Takahama

[学会発表] 死に行くT細胞へのレクイエム

高浜洋介

[学会発表] T cell repertoire formation in the thymus

Yousuke Takahama

[学会発表] Attacking the endocrine system: what is AIRE doing?

Yousuke Takahama

[学会発表] T lymphocyte repertoire formation in thymic microenvironments

Yousuke Takahama

[学会発表] Aire+ thymic medullary epithelial cells originate from beta 5t+ progenitor cells

Yousuke Takahama

[学会発表] Development and developmental potential of β 5t-expressing thymic epithelial cells

Yousuke Takahama

[学会発表] The thymic micro environments that shape T cell repertoire

Yousuke Takahama

[学会発表] Development and developmental potential of cTECs

Yousuke Takahama

[学会発表] Thymic microenvironments for T cell repertoire formation

Yousuke Takahama

[学会発表] Immune cells need stromal cells to work

Yousuke Takahama

[学会発表] 胸腺微小環境と自己免疫性涙腺異常

高浜洋介

[学会発表] 胸腺上皮細胞によるT細胞選択

高浜洋介

[学会発表] Tリンパ球レパトアを形成する胸腺微小環境

高浜洋介