トップ›研究者を探す›脳由来神経栄養因子を基軸とした脳・腸と連関する脂肪肝炎の病態解明と新たな治療戦略

脳由来神経栄養因子を基軸とした脳・腸と連関する脂肪肝炎の病態解明と新たな治療戦略

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22K07024
研究種目 基盤研究(C)
研究分野
研究機関 徳島大学
代表研究者 常山 幸一
研究分担者 清水 真祐子
研究分担者 井之上 浩一
研究期間 開始年月日 2022/4/1
研究期間 終了年度 2024
研究ステータス 交付 (2023/4/1)
配分額（合計） 4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
配分額（履歴） 2024年度：1,040,000 (直接経費 :800,000、間接経費 :240,000)
2023年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2022年度：1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード 非アルコール性脂肪性肝疾患（NAFLD）
代謝障害関連脂肪肝炎（MASH）
脳由来神経栄養因子（BDNF）
酸化ストレス
脳腸肝相関
BDNF
非アルコール性脂肪性肝疾患
うつ病
動物モデル
短鎖脂肪酸

研究成果

[雑誌論文] Spatial transcriptomics reveals prognosis‐associated cellular heterogeneity in the papillary thyroid carcinoma microenvironment

Yan Kai、Liu Qing‐Zhi、Huang Rong‐Rong、Jiang Yi‐Hua、Bian Zhen‐Hua、Li Si‐Jin、Li Liang、Shen Fei、Tsuneyama Koichi、Zhang Qing‐Ling、Lian Zhe‐Xiong、Guan Haixia、Xu Bo 2024

[雑誌論文] Quantification of collagen fiber properties in alcoholic liver fibrosis using polarization-resolved second harmonic generation microscopy

Matsuzaki Saya、Hase Eiji、Takanari Hiroki、Hayashi Yuri、Hayashi Yusaku、Oshikata Haruto、Minamikawa Takeo、Kimura Satoko、Ichimura-Shimizu Mayuko、Yasui Takeshi、Harada Masafumi、Tsuneyama Koichi 2023

[学会発表] Connexin 32 expression and alpha-synuclein accumulation in ballooning cells of non-alcoholic steatohepatitis (NASH) and other inflammatory liver diseases

Koichi Tsuneyama, Takumi Kakimoto,Mayuko Shimizu 2023

[雑誌論文] The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis

OMAGARI Katsuhisa、MARUTA Ayumi、YAYAMA Natsuki、YOSHIDA Yuki、OKAMOTO Kyoko、SHIROUCHI Bungo、TAKEUCHI Shouhei、SURUGA Kazuhito、KOBA Kazunori、ICHIMURA-SHIMIZU Mayuko、TSUNEYAMA Koichi 2023

[雑誌論文] Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis

Yamashita Maho、Honda Akira、Shimoyama Shin、Umemura Masahiro、Ohta Kazuyoshi、Chida Takeshi、Noritake Hidenao、Kurono Nobuhito、Ichimura-Shimizu Mayuko、Tsuneyama Koichi、Miyazaki Teruo、Tanaka Atsushi、Leung Patrick S.C.、Gershwin M. Eric、Suda Takafumi、Kawata Kazuhito 2023

[雑誌論文] Definitive Confirmation of Erythropoietic Protoporphyria via Re-biopsy Three Years After Initial Liver Biopsy at Age 15

Miyakami Yuko、Minamikawa Takeo、Ogawa Hirohisa、Ichimura-Shimizu Mayuko、Tsuneyama Kohichi 2023

[雑誌論文] Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen

Sumida Satoshi、Ichimura-Shimizu Mayuko、Miyakami Yuko、Kakimoto Takumi、Kobayashi Tomoko、Saijo Yasuyo、Matsumoto Minoru、Ogawa Hirohisa、Oya Takeshi、Bando Yoshimi、Uehara Hisanori、Taira Shu、Shimada Mitsuo、Tsuneyama Koichi 2023

[雑誌論文] Brain‐derived neurotrophic factor knock‐out mice develop non‐alcoholic steatohepatitis

Ichimura‐Shimizu Mayuko、Kojima Masami、Suzuki Shingo、Miyata Misaki、Osaki Yui、Matsui Konomi、Mizui Toshiyuki、Tsuneyama Koichi 2023

[学会発表] ESTABLISHMENT of EARLY FIBROSIS MARKER in NASH USING SERUM PHOSPHOLIPIDS

Miyakami Yuko, Mayuko Shimizu, Yoshimura Kentaro, Tsutsui Akemi, Koichi Tsuneyama 2023

[雑誌論文] Effect of daikenchuto (TU-100) on carcinogenesis in non-alcoholic steatohepatitis

Yamada Shinichiro、Morine Yuji、Imura Satoru、Ikemoto Tetsuya、Saito Yu、Shimizu Mayuko、Tsuneyama Koichi、Nishiyama Mitsue、Ishizawa Shiori、Shimada Mitsuo 2023

[雑誌論文] Accumulation of α-synuclein in hepatocytes in nonalcoholic steatohepatitis and its usefulness in pathological diagnosis

Kakimoto Takumi、Hosokawa Masato、Ichimura-Shimizu Mayuko、Ogawa Hirohisa、Miyakami Yuko、Sumida Satoshi、Tsuneyama Koichi 2023

[学会発表] 最近の肝臓病理の動向

常山 幸一 2023

[雑誌論文] Serum/glucose starvation strikingly reduces heterogeneous nuclear ribonucleoprotein A1 protein and its target, cyclin D1

Takahashi Tetsuyuki、Ando Yuri、Ichikawa Hirona、Tsuneyama Koichi、Hijikata Takao 2023

[学会発表] 最近の肝生検の動向;病理診断に何が求められているか?

常山 幸一 2023

[学会発表] New imaging techniques useful for pathological diagnosis

Koichi Tsuneyama 2023

[雑誌論文] Spontaneous development of an autoimmune hepatitis primary biliary cholangitis overlap syndrome in dnTGFβRII Aire-/- mice

Long Jie、Yang Si‐Yu、Huang Meng‐Xing、Luo Pan‐Yue、Li Liang、Tsuneyama Koichi、Ansari Aftab A、Lu Ling、Gershwin M Eric、Lian Zhe‐Xiong、Zhao Zhi‐Bin 2023

[雑誌論文] Short-chain fatty acids profiling in biological samples from a mouse model of Sjogren's syndrome based on derivatized LC-MS/MS assay

Nagatomo Ryosuke、Kaneko Haruki、Kamatsuki Shihori、Ichimura-Shimizu Mayuko、Ishimaru Naozumi、Tsuneyama Koichi、Inoue Koichi 2022

[学会発表] リソソーム酸性リパーゼ欠損症および高脂肪・コレステロール・コール酸食誘導NASHモデルマウスの病理所見の近似性

清水真佑子、常山幸一 2022

[雑誌論文] Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice

Shao Wenhua、Jargalsaikhan Orgil、Ichimura-Shimizu Mayuko、Cai Qinyi、Ogawa Hirohisa、Miyakami Yuko、Atsumi Kengo、Tomita Mitsuru、Sutoh Mitsuko、Toyohara Shunji、Hokao Ryoji、Kudo Yasusei、Oya Takeshi、Tsuneyama Koichi 2022

[学会発表] NASH線維化亢進モデルマウス"3-Fマウス"における腸内細菌叢及び胆汁酸組成の変化

西 海智, 常山 幸一, 清水 真祐子, 長井 良憲 2022

[雑誌論文] Influence of Fasting Time on Serum and Hepatic Lipid Profiles in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis

OMAGARI Katsuhisa、UCHIDA Miku、TAGAWA Yumeno、YOGO Mizuki、INAGAKI Kae、HONGO Ryoko、TAKEUCHI Shouhei、SURUGA Kazuhito、KOBA Kazunori、ICHIMURA-SHIMIZU Mayuko、TSUNEYAMA Koichi 2022

[雑誌論文] Dietary Cholic Acid Exacerbates Liver Fibrosis in NASH Model of Sprague Dawley Rats Fed a High-Fat and High-Cholesterol Diet

Ichimura-Shimizu Mayuko、Watanabe Shiro、Kashirajima Yuka、Nagatomo Ami、Wada Hitomi、Tsuneyama Koichi、Omagari Katsuhisa 2022

[雑誌論文] The gut microbiome contributes to splenomegaly and tissue inflammation in a murine model of primary biliary cholangitis

Wang Cheng-Bo、Wang Yan、Yao Yuan、Wang Jin-Jun、Tsuneyama Koichi、Yang Qiong、Liu Bin、Selmi Carlo、Gershwin M. Eric、Yang Shu-Han、Lian Zhe-Xiong 2022