研究成果

[雑誌論文] Diffuse but Non-homogeneous Brain Atrophy: Identification of Specific Brain Regions and Their Correlation with Clinical Severity in Rett Syndrome

Narita Hajime、Natsume Jun、Suzuki Takeshi、Shiohama Tadashi、Kawaguchi Masahiro、Okazaki Masaki、Hashizume Atsushi、Naganawa Shinji、Ito Yuji、Yamamoto Hiroyuki、Nakata Tomohiko、Kidokoro Hiroyuki、Takahashi Yoshiyuki、Takahashi Satoru、Tsujimura Keita 2025

[雑誌論文] Loss of Bach2 in T cells causes prolonged allergic inflammation through accumulation of effector T cells and disruption of epidermal barrier

Omori-Miyake Miyuki、Kawakami Ryosuke、Kuwahara Makoto、Okabe Masataka、Muto Jun、Imamura Takeshi、Yamashita Masakatsu 2025

[学会発表] Neuronal individuality by clustered protocadherins

Yagi Takeshi 2025

[雑誌論文] Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration

Yu Xinyi、Kawakami Ryosuke、Yambe Shinsei、Yoshimoto Yuki、Sasaki Takako、Higuchi Shinnosuke、Watanabe Hitomi、Akiyama Haruhiko、Miura Shigenori、Hu Kadi、Kondoh Gen、Sagasaki Ramu、Inui Masafumi、Adachi Taiji、Docheva Denitsa、Imamura Takeshi、Shukunami Chisa 2025

[雑誌論文] Graded arc beam in light needle microscopy for axially resolved, rapid volumetric imaging without nonlinear processes

Kume Daisuke、Kozawa Yuichi、Kawakami Ryosuke、Ishii Hirokazu、Watakabe Yuki、Uesugi Yuuki、Imamura Takeshi、Nemoto Tomomi、Sato Shunichi 2024

[学会発表] Brain remodeling induced by early transient SSRI impacts on social behavior in zebrafish

Sato Tomomi, Saito Kaito, Oyu Tsubasa, Tsuda Sachiko, Kurisaki Tomohiro, Kajihara Takeshi, Nagashima Masabumi 2024

[学会発表] 腫瘍抑制因子Meninはリソソーム恒常性の維持を介してCD8 T細胞老化を制御する

鈴木 淳平、川上 良介、今村 健志、山下 政克 2024

[学会発表] Observation of fine three-dimensional structure of cartilage: two-photon excitation microscopy using a transparency agent and a novel solvatochromic dye

Mori Hideki, Kawakami Ryosuke, Tsuda Teruko, Yatsuzuka Kazuki, Yoshida Satoshi, Muto Jun, Tozawa Asami, Shiraishi Ken, Imamura Takeshi, Fujisawa Yasuhiro 2024

[学会発表] Impaired neural development and social behavior of growth-restricted embryos by early transient SSRI

Sato Tomomi, Saito Kaito, Oyu Tsubasa, Tsuda Sachiko, Kurisaki Tomohiro, Kajihara Takeshi, Nagashima Masabumi 2024

[学会発表] Identification of Transcriptional Factors and Nuclear Receptors Regulating Cardiomyocyte Maturation in vitro

Chanthra Nawin, Ahmed Abbas Razan Elfadil, Torizal Fuad Grandhi, Tokuyama Takeshi, Uosaki Hideki 2024

[雑誌論文] Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system

Yamamoto Shigenori、Yamamoto Shinya、Takahashi Masahiro、Mii Akiko、Okubo Akihiro、Toriu Naoya、Nakagawa Shunsaku、Abe Takaaki、Fukuma Shingo、Imamura Hiromi、Yamamoto Masamichi、Yanagita Motoko 2024

[学会発表] バイオフォトニクスが拓く次世代口腔組織培養研究

今村 健志 2024

[学会発表] Impaired neural development and social behavior of growth-restricted embryos by early transient SSRI

Sato Tomomi, Saito Kaito, Oyu Tsubasa, Tsuda Sachiko, Kurisaki Tomohiro, Kajihara Takeshi, Nagashima Masabumi 2024

[学会発表] 革新的バイオイメージング技術開発とがん研究応用

今村 健志 2024

[学会発表] 新規皮膚腫瘍断端部観察方法の開発：二光子励起顕微鏡による３次元イメージング

吉田 諭、川上 良介、仁 陽輔、今村 健志、菱川 善隆、村上 正基 2024

[雑誌論文] Trehalose Prevents IL-4/IL-13-Induced Skin Barrier Impairment by Suppressing IL-33 Expression and Increasing NRF2 Activation in Human Keratinocytes In Vitro

Dai Xiuju、Mizukami Yoichi、Watanabe Kenji、Tsuda Teruko、Shidahara Mutsumi、Yoshida Satoshi、Yatsuzuka Kazuki、Shiraishi Ken、Mori Hideki、Murakami Masamoto、Kawakami Ryosuke、Imamura Takeshi、Fujisawa Yasuhiro、Muto Jun 2024

[学会発表] PKRとその下流分子に着目した肝細胞癌制御機構の解明

奥嶋 優介、渡辺 崇夫、小泉 光仁、今村 健志、日浅 陽一 2024

[学会発表] Development of Acto3D, a user- and budget-friendly open-source software, for multichannel high-resolution three-dimensional imaging

Yashiro Kenta, Takeshita Naoki, Sakaki Shinichiro, Saba Rie, Iehara Tomoko 2024

[学会発表] Visualization of dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal development

Yu Xiny, Kawakami Ryosuke, Yambe Shinsei, Yoshimoto Yuki, Sasaki Takako, Akiyama Haruhiko, Adachi Taiji, Imamura Takeshi, Shukunami Chisa 2024

[雑誌論文] Novel role of zinc-finger protein 518 in heterochromatin formation on α-satellite DNA

Ohta Shinya、Ohzeki Jun-Ichirou、Sato Nobuko、Tanizawa Hideki、Chung Claire Yik-Lok、Noma Ken-Ichi、Masumoto Hiroshi 2024

[学会発表] Gravity signaling mechanism in Arabidopsis gravitropism

Nishimura Takeshi, Hirano Yoshinori, Furutani Masahiko, Nakamura Moritaka, Hakoshima Toshio, Morita Terao Miyo. 2023

[学会発表] Genome-wide cis-decoding with explainable deep learning identifies lineage-specific evolution of cis-trans interactive networks in kiwifruit ripening

Kuwada Eriko, Takeshita Kouki, Fujita Naoko, Kubo Yasutaka, Ushijima Koichiro, Uchida Seiichi, Akagi Takashi 2023

[学会発表] Bright two-photon-active fluorescent dyes for staining lipid membrane

上村 拓巳、川上 良介、今村 健志、波多野 慎悟、渡辺 茂、仁子 陽輔 2023

[学会発表] Brain remodeling induced in growth-restricted zebrafish embryos by antidepressant SSRI during early development

Sato Tomomi, Saito Kaito, Oyu Tsubasa, Tsuda Sachiko, Kurisak Tomohiro, Kajihara Takeshi, Nagashima Masabumi 2023

[学会発表] 軟骨の微細三次元構造観察　-透明化剤および新規ソルバクトクロミック色素を用いた二光子励起顕微鏡観察法-

森 秀樹、川上 良介、戸澤 麻美、村上 達郎、泉本 真美子、浅野 遥奈、船木 杏奈、村上 正基、今村 健志 2023

[学会発表] Neuronal ensemble activities in the dentate gyrus for fear generalization

Jiahui Yu, Pablo Vergara, Yuteng Wang, Naoi Toshie, Yoan Cherasse, Sugaya Yuki, Kano Masanobu, Sakurai Takeshi, Sakaguchi Masanori 2023

[学会発表] Laser-based miniaturized microscopes for simultaneous neuronal imaging and manipulation in freely moving animals

Yuteng Wang, Pablo Vergara, Yoan Cherasse, Naoi Toshie, Sakurai Takeshi, Sugaya Yuki, Kano Masanobu, Sakaguchi Masanori 2023

[学会発表] The role of LAZY1-LIKE 4 in the signaling process in the gravity sensing cells in root gravitropism

Morita Miyo T., Nishimura Takeshi, Mori Shogo, Shikata Hiromasa, Nakamura Moritaka, Hashiguchi Yasuko, Abe Yoshinori, Hagihara Takuma, Yoshikawa Hiroshi, Toyota Masatsugu, Higaki Takumi 2023

[学会発表] 論文発表に難渋しているマウス2系統

今村 健志 2023

[学会発表] Accumulation of T cells with Bach2 expression at a low level could cause a prolonged inflammation of allergic contact dermatitis in mice

Omori-Miyake Miyuki, Kawakami Ryosuke, Imamura Takeshi, Yamashita Masakatsu 2023

[学会発表] Combinations of nuclear receptor activations revealed disease phenotype in iPSC-CMs derived from patients with mitochondrial cardiomyopathy

Ahmed Razan, Chanthra Nawin, Iwabuchi Kumiko, Tokuyama Takeshi, Uosaki Hideki 2023

[雑誌論文] Transcriptomic Interpretation on Explainable AI-Guided Intuition Uncovers Premonitory Reactions of Disordering Fate in Persimmon Fruit

Masuda Kanae、Kuwada Eriko、Suzuki Maria、Suzuki Tetsuya、Niikawa Takeshi、Uchida Seiichi、Akagi Takashi 2023

[学会発表] Reactivation of adult-born neuron ensembles in REM sleep for memory consolidation

Sakaguchi Masanori, Koyanagi Iyo, Pablo Vergara, Yuteng Wang, Jiahui Yu, Naoi Toshie, Kapar E Vogt, Yoan Cherasse, Kutsumura Noriki, Sugaya Yuki, Kano Masanobu, Sakurai Takeshi, Tezuka Taro, Sakthivel Srinivasan 2023

[雑誌論文] Extended Depth of Focus Two-Photon Light-Sheet Microscopy for In Vivo Fluorescence Imaging of Large Multicellular Organisms at Cellular Resolution

Saitou Takashi、Imamura Takeshi 2023

[学会発表] Structural analysis of a heme-containing oxygen sensor protein, HemAT

Tohda Rei, Muraki Norifumi, Takeshi Yokoyama, Aono Shigetoshi 2023

[学会発表] Implantable in-vivo pH image sensor with integrated reference electrode for biological experiments on awake mouse

Madokoro Mai, Nakamura Yuto, Horiuchi Hiroshi, Kobayashi Tomoko, Ishida Junko, Horio Tomoko, Kimura Yasuyuki, Hizawa Takeshi, Akai Daisuke, Doi Hideo, Yong-Joon Choi, Takahashi Kazuhiro, Noda Toshihiko, Nabekura Junichi, Sawada Kazuaki 2023

[学会発表] CaliAli: Long-term tracking of drifting neural representations

Pablo Vergara, Yuteng Wang, Sakthivel Srinivasan, Naoi Toshie, Yoan Cherasse, Sugaya Yuki, Sakurai Takeshi, Kano Masanobu, Sakaguchi Masanori 2023

[学会発表] 革新的バイオイメージング技術が拓く次世代泌尿器科学研究と医療応用

今村 健志 2023

[学会発表] Maturation culture exaggerated disease phenotype in mitochondrial cardiomyopathy iPSC-derived cardiomyocytes

Ahmed Razan, Chanthra Nawin, Iwabuchi Kumiko, Tokuyama Takeshi, Uosaki Hideki 2023

[学会発表] Synthesis of new pyrene-based D-π-A dyes and their application to skin tissue imaging

橋本 拓弥、川上 良介、村上 正基、今村 健志、波多野 慎悟、渡辺 茂、仁子 陽輔 2023

[学会発表] 愛媛発革新的バイオイメージング技術開発と応用

今村 健志 2023

[学会発表] Application of advanced optical imaging to cancer research

Imamura Takeshi 2023

[雑誌論文] Knockout of all ErbB-family genes delineates their roles in proliferation, survival and migration

Matsuda Kimiya、Hirayama Daiki、Hino Naoya、Kuno Sota、Sakaue-Sawano Asako、Miyawaki Atsushi、Matsuda Michiyuki、Terai Kenta 2023

[雑誌論文] Visual quantification of prostaglandin E₂ discharge from a single cell

Watabe Tetsuya、Yamahira Shinya、Matsuda Michiyuki、Terai Kenta 2023

[雑誌論文] Pyrene-fused dioxaborine-based merocyanines with high brightness, photostability, and fluorogenic function for deep-skin tissue imaging of a living mouse

Nishihara Haruka、Watanabe Mai、Kawakami Ryosuke、Murakami Masamoto、Seki Hitomi、Osaki Katsuki、Tsuda Teruko、Imamura Takeshi、Hadano Shingo、Watanabe Shigeru、Niko Yosuke 2023

[雑誌論文] Microglia enable cross-modal plasticity by removing inhibitory synapses

Hashimoto Akari、Kawamura Nanami、Tarusawa Etsuko、Takeda Ikuko、Ohno Nobuhiko、Kato Daisuke、Aoyama Yuki、Matsumoto Mami、Hasegawa Yoshihiro、Nabekura Junichi、Schaefer Anne、Moorhouse Andrew J.、Yagi Takeshi、Wake Hiroaki 2022

[学会発表] 革新的バイオイメージングが拓く次世代生物化学的測定

今村 健志 2022

[学会発表] Disease modeling of mitochondrial cardiomyopathy using patient-derived induced pluripotent stem cells

Razan Ahmed, Nawin Chanthra, Iwabuchi Kumiko, Tokuyama Takeshi, Uosaki Hideki 2022

[学会発表] The off-axis rotor of Enterococcus hirae V-type ATPase by volta phase and conventional phase contrast cryo-EM

Burton-Smith Raymond, Tsunoda Jun, Song Chihon, Ueno HiroshHi, Murata Takeshi, Iino Ryota, Murata Kazuyoshi 2022

[雑誌論文] Computer-aided detection of quantitative signatures for breast fibroepithelial tumors using label-free multi-photon imaging

Kobayashi-Taguchi Kana、Saitou Takashi、Kamei Yoshiaki、Murakami Akari、Nishiyama Kanako、Aoki Reina、Kusakabe Erina、Noda Haruna、Yamashita Michiko、Kitazawa Riko、Imamura Takeshi、Takada Yasutsugu 2022

[学会発表] The off-axis rotor of Enterococcus hirae V-type ATPase by volta phase and conventional phase contrast cryo-EM

Burton-Smith Raymond, Tsunoda Jun, Song Chihon, Ueno HiroshHi, Murata Takeshi, Iino Ryota, Murata Kazuyoshi 2022

[学会発表] The role of the transcription factor PITX2c in morphogenesis of the cardiac outflow tract

Sakaki Shinichiro, Matsuo Kazuhiko, Shigeta Masaki, Saba Rie, Nakajima Nakajima Yoshiro, Kobayahi Daisuke, Inoue Satoshi, Takeshita Naoki, Kamiyama Atsuko, Nishikawa Kosuke, Inuzuka Ryo, Harita Yutaka, Kato Motohiro, Oka Akira, Onodera Hiroshi, Yashiro Kenta 2022

[学会発表] Directional gravity sensing in plant gravitropism

Morita Terao Miyo, Mori Shogo, Nishimura Takeshi, Shikata Hiromasa, Toyota Masatsugu, Higaki Takumi, Abe Yoshinori, Hagihara Takuma, Yoshikawa Hiroshi 2022

[学会発表] 革新的バイオイメージング技術が拓く次世代皮膚科学

今村 健志 2022

[学会発表] The off-axis rotor of Enterococcus hirae V-type ATPase by volta phase and conventional phase contrast cryo-EM

Burton-Smith Raymond, Tsunoda Jun, Song Chihon, Ueno HiroshHi, Murata Takeshi, Iino Ryota, Murata Kazuyoshi 2022

[雑誌論文] Deep Learning Predicts Rapid Over-softening and Shelf Life in Persimmon Fruits

Suzuki Maria、Masuda Kanae、Asakuma Hideaki、Takeshita Kouki、Baba Kohei、Kubo Yasutaka、Ushijima Koichiro、Uchida Seiichi、Akagi Takashi 2022

[学会発表] Explainable AI (X-AI) uncovers lineage-specific cis-trans interactive networks for fruit ripening: a comparative case of tomato and kiwifruit

Kuwada Eriko, Takeshita Kouki, Fujita Naoko, Uchida Seiichi, Akagi Takashi 2022

[学会発表] 腫瘍抑制因子Meninはリソソーム-オートファジー系の調節を介してT細胞老化を制御する

鈴木 淳平、川上 良介、今村 健志、山下 政克 2022

[学会発表] Whole body imaging of cancer model Medaka using a wide field light-sheet microscopy

Imamura Takeshi 2022

[学会発表] 整形外科分野でのバイオイメージング開発の最前線

今村 健志 2022

[雑誌論文] Differences in interaction lead to the formation of different types of insulin amyloid

Mori Wakako、Kawakami Ryosuke、Niko Yosuke、Haruta Tomohiro、Imamura Takeshi、Shiraki Kentaro、Zako Tamotsu 2022

[学会発表] バイオイメージング総論

今村 健志、川上 良介、齋藤 卓、村上 正基、佐山 浩二 2022

[学会発表] Conserved Map7/7D1/Ens proteins coordinate microtubule remodeling and Wnt/PCP signaling for cell polarity formation

Kikuchi Koji, Nakagawa Mami, Fujimori Toshihiko, Araki Kimi, Shimamura Kenji, Ohta Kunimasa, Nakamura Akira, Suzuki Makoto, Ishiguro Kei-ichiro 2022

[学会発表] Paired comparisons of eleven species with different fertilization modes reveal the evolution of sperm in marine fishes

Ito Takeshi, Morita Masaya, Okuno Seiya, Inaba Kazuo, Munehara Hiroyuki, Homma Mitsuo, Awata Satoshi 2022

[学会発表] 多光子励起ラベルフリーイメージングを利用した乳腺腫瘤のコンピュータ支援診断

齋藤 卓、田口 加奈、亀井 義明、今村 健志 2022

[学会発表] Computational approach to development of non-linear optical microscopy and quantitative tumor imaging

齋藤 卓、今村 健志 2022

化合物、蛍光色素剤、キット、細胞の検出方法、及び、染色用材料

化合物、蛍光色素剤、キット、細胞膜の検出方法、及び、染色用材料