トップ研究者を探す悪性黒色腫におけるPeriostinの機能解析

悪性黒色腫におけるPeriostinの機能解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22791100
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
内科系臨床医学
皮膚科学
研究機関 独立行政法人医薬基盤研究所
代表研究者 世良田 聡
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
配分額(履歴) 2012年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2011年度:1,040,000 (直接経費 :800,000、間接経費 :240,000)
2010年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
キーワード
periostin
Periostin

研究成果

[学会発表] Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud' s Phenomenon

Satoshi Serada, Minoru Fujimoto, Tetsuji Naka 2012

[雑誌論文] Anti-proliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells

Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T 2012

[雑誌論文] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulceratiVe colitis

Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T 2012

[雑誌論文] Periostin Facilitates Skin Sclerosis via PI3K/Akt Dependent Mechanism in a Mouse Model of Scleroderma

Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I 2012

[学会発表] Quantitative proteomic analysis of tumor growth associated proteins in cutaneous malignant melanoma Short title: Proteomics of melanoma

Satoshi Serada, Yorihisa Kotobuki, Atsushi Tanemura, Ichiro Katayama, Tetsuji Naka 2012

[雑誌論文] Dysregulation of Melanocyte Function by Th17-related Cytokines: Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris

Kotobuki Y, Tanemura A, Yang L, Itoi S, Kaneda M, Murota H, Fujimoto M, Serada S, Naka T Katayama I 2012

[雑誌論文] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis

Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T 2012

[雑誌論文] Periostin, a matricellular protein

Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Narisawa Y, Katayama I, Izuhara K, Naka T 2012

[学会発表] 定量的リン酸化プロテオーム解析による消化管間質腫瘍のイマチニブ耐性因子の探索

世良田聡,高橋剛,浦瀬真伊子,藤本穣,原田絵美,西田俊朗,仲哲治 2012

[学会発表] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis

Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka 2011

[雑誌論文] Anti-proliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells

Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T 2011

[学会発表] Periostin, a matricellular protein, accelerates wound repair by activating dermal fibroblasts

Yorihisa Kotobuki, Kanako Ontsuka, Satoshi Serada, Hiroshi Shiraishi, Atsushi Tanemura, Shoichiro Ohta, Lingli Yang, Tetsuji Naka, Kenji Izuhara, Ichiro Katayama 2011

[雑誌論文] Overexpression of SOCS3 exhibits preclinical antitunlor activity against malignant pleural mesothelioma

Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Chun Man Lee, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T 2011

[雑誌論文] Dysregulation of Melanocyte Function by Th17-related Cytokines : Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris

Kotobuki Y, Tanemura A, Yang L, Itoi S, Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I 2011

[雑誌論文] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells.

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T. 2011

[雑誌論文] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T 2011

[雑誌論文] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T 2011

[雑誌論文] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T 2011

[学会発表] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索

Satoshi Serada, Takuhei Yokoyama, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka 2011

[学会発表] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索

世良田聡,横山拓平,榎本隆之,松崎慎哉,森本晶子,金雅子,藤本穣,木村正,仲哲治 2011

[雑誌論文] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Chun Man Lee, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T 2011

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 But Also Interphotoreceptor Retinoid Binding Protein-Specific Thl By Promoting Regulatory T cell In Experimental Autoimmune Uveoretinitis

Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T 2011

[学会発表] Periostin, a matricellular protein, accelerates wound repair by activating dermal fibroblasts

Yorihisa Kotobuki, Kanako Ontsuka, Satoshi Serada, Hiroshi Shiraishi, Atsushi Tanemura, Shoichiro Ohta, Lingli Yang, Tetsuji Naka, Kenji Izuhara, Ichiro Katayama 2011

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 But Also Interphotoreceptor Retinoid Binding Protein-Specific Th1 By Promoting Regulatory T cells In Experimental Autoimmune Uveoretinitis

Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T 2011

[図書] 医学のあゆみサイトカインシグナル伝達抑制分子(SOCS)の新規抗癌剤としての応用

世良田聡, 仲哲治 2010

[学会発表] SOCS-1,-3 GENE DELIVERY IN GASTRIC CANCER CELLS INDUCES A POTENT ANTI-PROLIFERATIVE EFFECT VIA THE SUPPRESSION OF JAK/STAT AND P38 MAPK SIGNALING PATHWAYS

Serada S, Souma Y, Nishida T, Fujimoto M, Naka T 2010

[学会発表] 自己免疫疾患の新規活動性マーカーとしてのleucine rich alpha 2 glycoprotein Proteomics-based identification of leucine rich alpha 2 glycoprotein(LRG)as a novel biomarker associated with disease activity of inflammatory autoimmune disorders

世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治 2010

[雑誌論文] Blockade of Interleukin-6 Signaling SupPresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses

Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T 2010

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Th17 Responses.

Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T. 2010

[図書] サイトカインシグナル伝達抑制分子(SOCS)の新規抗癌剤としての応用

世良田聡,仲哲治 2010

[学会発表] lLabotatory For Immune Signal, National Institute of Biomedical Innovation, Ibaraki City (Osaka)/JAPAN, 2 Surgery, Osaka University, Suita/JAPAN, 3 Surgery, Osaka Police Hospital, Osaka/JAPAN, 4 Laboratory For Immune Signal, National Institute of Biomedical Innovation, Ibaraki City (Osaka)/JAPAN

S. Serada, Y. Souma, T. Nishida, M. Fujimoto, T. Naka 2010

[学会発表] 自己免疫疾患の新規活動性マーカーとしてのleucine rich alpha 2 glycoprotein

世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治 2010

[学会発表] Quantitative proteomic analysis of tumor growth associated proteins in cutaneous malignant melanoma

Serada S, Kotobuki Y, Tanemura A, Katayama I, Naka T

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