トップ›研究者を探す›膜型増殖因子のshedding制御を標的とした心筋細胞の生存機構の解明とその応用

膜型増殖因子のshedding制御を標的とした心筋細胞の生存機構の解明とその応用

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22790319
研究種目 若手研究(B)
研究分野 生物系
医歯薬学
基礎医学
病態医化学
研究機関 愛媛大学
代表研究者 福田 信治
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2011
研究ステータス 完了 (2011/4/1)
配分額（合計） 3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
配分額（履歴） 2011年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000)
2010年度：2,080,000 (直接経費 :1,600,000、間接経費 :480,000)
キーワード 膜型増殖因子
ectodomain shedding
HB-EGF
Amphiregulin
アネキシン
ADAM17

研究成果

[雑誌論文] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding

Shinji Fukuda 2012

[雑誌論文] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer

Yoshida Michihiro 2012

[雑誌論文] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of pro-amphiregulin

Hironao Nakayama 2012

[雑誌論文] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin

Nakayama H, Fukuda S, Inoue H, Nishida-Fukuda H, Shirakata Y, Hashimoto K, Higashi yama S 2012

[雑誌論文] Nuclear translocation of pro-amphiregulin induces chemoresistance in gastric cancer

Yoshida M, Shimura T, Fukuda S, Mizoshita T, Tanida S, Kataoka H, Kamiya T, Nakazawa T, Higashiyama S, Joh T 2012

[雑誌論文] BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis

Ohnuki H, Inoue H, Takemori N, Nakayama H, Sakaue T, Fukuda S, Miwa D, Nishiwaki E, Hatano M, Tokuhisa T, Endo Y, Nose M, Higashiyama S 2012

[雑誌論文] ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members

Shigematsu S, Fukuda S, Nakayama H, Inoue H, Hiasa Y, Onji M, Higashiyama S 2012

[雑誌論文] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S 2012

[学会発表] The Role of monoubiquitination in the regulation of endocytosis and ectodomain shedding of a ligand for epidermal growth factor (EGF) receptor, Amphiregulin

Shinji Fukuda 2011

[学会発表] HB-EGF-CTF nuclear translocation induces gastric cancer invasion

Shimura T, Yoshida M, Fukuda S, Mizoshita T, Kataoka H, Higashiyama S, Joh T 2011

[雑誌論文] Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands

Higashiyama S, Nanba D, Nakayama H, Inoue H, Fukuda S 2011

[学会発表] ZNF689の肝細胞癌におけるアポトーシス抑制機構

重松秀一郎, 福田信治, 中山寛尚, 日浅陽一, 恩地森一, 東山繁樹 2011

[学会発表] Amphiregulin nuclear translocation might cause poor prognosis due to chemotherapeutic resistance in gastric cancer

Yoshida M, Shimura T, Fukuda S, Higashiyama S, Mizoshita T, Kataoka H, Joh T 2011

[学会発表] The Role of monoubiquitination in the regulation of endocytosis and ectodomain shedding of a ligand for epidermal growth factor(EGF) receptor, Amphiregulin

Fukuda S, Nishida-Fukuda H, Nakayama H, Inoue H, Higashiyama S 2011

[学会発表] ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members

Shigematsu S, Fukuda S, Onji M, Higashiyama S 2011

[学会発表] ZNF689 suppresses apoptosis of hepatocellular carcinoma through the down-regulation of Bcl-2 family members

Shigematsu S, Hiasa Y, Fukuda S, Nakayama H, Onji M, Higashiyama S 2011

[学会発表] Identification of novel molecules that regulate ectodomain shedding of EGF ligands.シンポジウム" Ectodomain shedding biology-functional conversion of plasma membrane proteins"

Fukuda S, Nakayama H, Higashiyama S 2010

[学会発表] Identification of novel molecules that regulate ectodomain shedding of EGF ligands

Shinji Fukuda 2010

[学会発表] Characterization of ZNF689 in Human Hepatocelluar Carcinoma

Shigematsu S, Fukuda S, Nakayama H, Hiasa Y, Onji M, Higashiyama S 2010

[学会発表] 新規血管新生制御因子ZF50によるNotchシグナル解除機構

大貫秀隆, 井上博文, 中山寛尚, 福田信治, 三輪大輔, 東山繁樹 2010