転写因子ＴＦＩＩＨサブ複合体の構造解析

トップ›研究者を探す›転写因子ＴＦＩＩＨサブ複合体の構造解析

代表研究者	小森博文
研究課題番号	KAKENHI-PROJECT-22770110
研究種目	若手研究(B)
研究分野	生物系生物学生物科学構造生物化学
研究機関	香川大学兵庫県立大学
研究期間開始年月日	2010/4/1
研究期間終了年度	2013
研究ステータス	完了 (2013/4/1)
配分額（合計）	4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
配分額（履歴）	2013年度：650,000 (直接経費 :500,000、間接経費 :150,000) 2012年度：1,170,000 (直接経費 :900,000、間接経費 :270,000) 2011年度：1,170,000 (直接経費 :900,000、間接経費 :270,000) 2010年度：1,170,000 (直接経費 :900,000、間接経費 :270,000)
キーワード	タンパク質Ｘ線結晶構造解析結晶転写因子タンパク質の精製タンパク質複合体 X線結晶解析 TFIIH TFIIE

研究成果

[雑誌論文] New insights into the catalytic active site structure of multicopper oxidase

H. Komori, R. Sugiyama, K. Kataoka, K. Miyazaki, Y. Higuchi & T. Sakurai 2014

[雑誌論文] Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase

Y. Nitta, H. Kikuzakic, T. Azuma, Y. Ye, M. Sakaue, Y. Higuchi, H. Komori, & H. Ueno 2013

[雑誌論文] Cyrstal structure of the CueO mutants at Glu506, the key amino acid located in the proton transfer pathway for dioxygen reduction

H. Komori, T. Kajikawa, K. Kataoka, Y. Higuchi & T. Sakurai 2013

[雑誌論文] Photosensitivity of the Ni-A state of [NiFe] hydrogenase from D. vulgaris Miyazaki F with visible light

H. Osuka, Y. Shomura, H. Komori, N. Shibata, S. Nagao, Y. Higuchi, & S. Hirota 2013

[学会発表] 構造解析に向けた鉄調節性転写因子の精製

小森　博文 2013

[雑誌論文] Formation of Oligomeric Cytochrome c during Folding by Intermolecular Hydrophobic Interaction between Nand C-Terminal α-Helices

P. P. Parui, M. Deshpande, S. Nagao, H. Kamikubo, H. Komori, Y. Higuchi, M. Kataoka, & S. Hirota 2013

[雑誌論文] Cyrstal structure of the CueO mutants at Glu506, the key amino acid located in the proton transfer pathway for dioxygen reduction

H. Komori, T. Kajikawa, K. Kataoka, Y. Higuchi & T. Sakurai 2013

[雑誌論文] Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from B. subtilis

Y. Shomura, E. Hinokuchi, H. Ikeda, A. Senoo, Y. Takahashi, J. Saito, H. Komori, N. Shibata, Y. Yonetani, & Y. Higuchi 2012

[雑誌論文] Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase

Komori H, Nitta Y, Ueno H, Higuchi Y. 2012

[雑誌論文] Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.

Shomura Y, Hinokuchi E, Ikeda H, Senoo A, Takahashi Y, Saito J, Komori H, Shibata N, Yonetani Y, Higuchi Y. 2012

[雑誌論文] Photosensitivity of the Ni-A state of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F with visible light.

Osuka H, Shomura Y, Komori H, Shibata N, Nagao S, Higuchi Y, Hirota S. 2012

[雑誌論文] Domain swapping of the heme and N-terminal α-helix in Hydrogenobacter thermophilus cytochrome c(552) dimer.

Hayashi Y, Nagao S, Osuka H, Komori H, Higuchi Y, Hirota S. 2012

[雑誌論文] An O-centered structure of the trinuclear copper center in the Cys500Ser/Glu506Gln mutant of CueO and structural changes in low to high X-ray dose conditions.

Komori H, Sugiyama R, Kataoka K, Higuchi Y, Sakurai T. 2012

[学会発表] ヒト由来ヒスチジン脱炭酸酵素の構造解析

小森博文 2012

[雑誌論文] Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.

Komori H, Nitta Y, Ueno H, Higuchi Y. 2012

[学会発表] Structural basis for the histamine synthesis by human histidine decarboxylase

Hirofumi Komori 2012

[雑誌論文] An O-Centered Structure of the Trinuclear Copper Center in the Cys500Ser/Glu506Gln Mutant of CueO and Structural Changes in Low to High X-Ray Dose Conditions

H. Komori, R. Sugiyama, K. Kataoka, Y. Higuchi & T. Sakurai 2012

[学会発表] Ｘ線照射によるマルチ銅活性中心の構造変化

小森博文 2012

[雑誌論文] Domain swapping of the heme and N-terminal α-helix in Hydrogenobacter thermophilus cytochrome c552 dimer

Y. Hayashi, S. Nagao, H. Osuka, H. Komori, Y. Higuchi, & S. Hirota 2012

[雑誌論文] Structural study reveals Ser345 determines substrate specificity on human histidine

H. Komori, Y. Nitta, H. Ueno, & Y. Higuchi 2012

[雑誌論文] Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase.

Nitta Y, Kikuzaki H, Azuma T, Ye Y, Sakaue M, Higuchi Y, Komori H, Ueno H. 2012

[雑誌論文] Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase

H. Komori, Y. Nitta, H. Ueno, & Y. Higuchi 2012

[雑誌論文] Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd1

S. Terawaki, K. Yano, T. Katsutani, K. Shiomi, K. Keino-Masu, M. Masu, Y. Shomura, H. Komori, N. Shibata & Y. Higuchi 2011

[学会発表] マルチ銅酸化酵素の構造解析

小森博文 2011

[雑誌論文] Positively charged residues located downstream of PIP-box, together with TD amino acids within PIP-box, are important for CRL4Cdt2-mediated proteolysis

M. Michishita, A. Morimoto, T. Ishii, H. Komori, Y. Higuchi, Y. Shiomi & H. Nishitani 2011

[雑誌論文] Role of π-Electron Systems in Stabilization of the Oxidized Tetraheme Architecture in Cytochrome c3 and Structural Changes in Low to High X-Ray Dose Conditions

Y. Takayama, M. Taketa-Sato, H. Komori, K. Morita, SJ. Kang, Y. Higuchi, & H. Akutsu 2011

[雑誌論文] Crystal structure of a PFU-PUL domain pair of Saccharomyces cerevisiae Doa1/Ufd3

R. Nishimasu, H. Komori, Y. Higuchi, H. Nishimasu & H. Hiroaki 2010

[雑誌論文] Crystallization and preliminary X-ray analysis of dimeric and trimeric cytochromes c from horse heart

M. Taketa, H. Komori, Y. Hattori, S. Nagao, S. Hirota, & Y. Higuchi 2010

[学会発表] Reconstitution of the subcomplex of yeast TFIIH

小森博文 2010

[雑誌論文] Crystal structure analysis of Bacillus subtilis ferredoxin-NADP+ oxidoreductase and the structural basis for its substrate selectivity

H. Komori, D. Seo, T. Sakurai & Y. Higuchi 2010

[雑誌論文] Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates

N. Shibata, H. Tamagaki, S. Ohtsuki, N. Hieda, K. Akita, H. Komori, Y. Shomura, S. Terawaki, K. Mori, N. Yasuoka, Y. Higuchi & T. Toraya 2010

[雑誌論文] Cytochrome c polymerization by successive domain swapping at the C-terminal helix

S. Hirota, Y. Hattori, S. Nagao, M. Taketa, H. Komori, H. Kamikubo, Z. Wang, I. Takahashi, S. Negi, Y. Sugiura, M. Kataoka & Y. Higuchi 2010

[学会発表] 構造解析に向けた鉄調節性転写因子の精製

小森博文