トップ研究者を探す幹細胞マーカーNestinを標的とした膵癌新規治療の開発

幹細胞マーカーNestinを標的とした膵癌新規治療の開発

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22689038
研究種目 若手研究(A)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 日本医科大学
代表研究者 松田 陽子
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 10,270,000 (直接経費 :7,900,000、間接経費 :2,370,000)
配分額(履歴) 2012年度:2,990,000 (直接経費 :2,300,000、間接経費 :690,000)
2011年度:3,770,000 (直接経費 :2,900,000、間接経費 :870,000)
2010年度:3,510,000 (直接経費 :2,700,000、間接経費 :810,000)
キーワード nestin
膵癌
分子標的治療薬
浸潤
転移
癌幹細胞
Nestin
分子標的治療

研究成果

[図書] Evolution of the molecular biology of brain tumors and the therapeutic inplications. Nestin: Neural stem/progenitor marker in brain tumors.

Matsuda Y 2013

[雑誌論文] Nestin is highly expressed in advanced-stage melanomas and neurotized nevi

Akiyama M, Matsuda Y, Ishiwata T, Naito Z, Kawana S 2013

[雑誌論文] Inhibition of the stem cell marker nestin reduces tumor growth and invasion of malignant melanoma

Akiyama M, Matsuda Y, Ishiwata T, Naito Z, Kawana S 2013

[雑誌論文] a novel angiogenesis marker and possible target for tumor angiogenesis

Matsuda Y, Hagio M, Ishiwata T.Nestin 2013

[学会発表] Inhibition of phosphorylation of nestin decrease pancreatic cancer cell growth

Matsuda Y, et al 2013

[雑誌論文] Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas

Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T 2013

[図書] Nestin: Neural stem/ progenitor marker in brain tumors. Evolution of the molecular biology of brain tumors and the therapeutic implications

Matsuda Y, et al 2013

[学会発表] Inhibition of phosphorylation of nestin decrease pancreatic cancer cell growth

Matsuda Y 2013

[学会発表] Nestin regulating molecule network in pancreatic cancer. Pancreas Cancer 2012 in Kyoto

Matsuda Y, et al 2012

[学会発表] 膵癌転移巣における癌幹細胞および上皮間葉転換マーカーの発現

松田陽子 2012

[学会発表] EMT and stemness in human pancreatic cancer cells derived from metastatic foci of NOD/Shi-scid, IL-2γnull (NOG) mice.

Matsuda Y 2012

[雑誌論文] Clinicopathological features of 30 autopsy cases of pancreatic carcinoma.

Matsuda Y, Hagio M, Naito Z, Ishiwata T. 2012

[学会発表] EMT and stemness in human pancreatic cancer cells derived from metastatic foci of NOD/Shi-scid, IL-2γnull (NOG) mice

Matsuda Y, et al 2012

[雑誌論文] CD44 in human gliomas correlates with histopathological grade and cell migration

Yoshida T, Matsuda Y, Naito Z, Ishiwata T 2012

[学会発表] Nestin regulates stem cell functions of pancreatic cancer cells

Matsuda Y, et al 2012

[雑誌論文] Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation

Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z 2012

[学会発表] Nestin Regulating Molecule Network in Pancreatic Cancer.

Matsuda Y 2012

[雑誌論文] Clinicopathological Features of Thirty Autopsy Cases of Pancreatic Carcinoma

Matsuda Y, Hagio M, Naito Z, Ishiwata T 2012

[雑誌論文] Nestin and other putative cancer stem cell markers in pancreatic cancer

Matsuda Y, Kure S, Ishiwata T 2012

[学会発表] Nestin regulates stem cell functions of pancreatic cancer cells.

Matsuda Y 2012

[雑誌論文] Ultra-high-resolution images of nestin and vimentin in pancreatic carcinoma cells using 2 novel microscopy systems

Yoshimura H, Matsuda Y, Naito Z, Murase M, Kawamoto Y, Ishiwata T 2012

[雑誌論文] Effectiveness of nestin-targeting therapy in pancreatic cancer

Matsuda Y 2012

[雑誌論文] Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis

Yamahatsu K, Matsuda Y, Ishiwata T, Uchida E, Naito Z 2012

[雑誌論文] Ultra-high-resolution images of nestin and vimentin in pancreatic carcinoma cells using 2 novel microscopy systems.

Yoshimura H, Matsuda Y, Naito Z, Murase M, Kawamoto Y, Ishiwata T. 2012

[雑誌論文] Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer

Cho K, Matsuda Y, Ueda J, Uchida E, Naito Z, Ishiwata T 2012

[雑誌論文] Secreted 70 kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer

Yamamoto T, Matsuda Y, Kawahara K, Ishiwata T, Naito Z 2012

[雑誌論文] Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

Ishiwata T, Matsuda Y, Naito Z 2011

[雑誌論文] Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis.

Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T. 2011

[学会発表] Nestin regulates pancreatic cancer stem cell functions

Matsuda Y, et al 2011

[雑誌論文] Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis

Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T 2011

[学会発表] Nestin regulates pancreatic cancer stem cell functions. American association for cancer research

Matsuda Y, et al 2011

[雑誌論文] Comparison of fixation methods for preservation of morphology, RNAs, and proteins from paraffin-embedded human cancer cell-implanted mouse models

Matsuda Y, Fujii T, Suzuki T, Yamahatsu K, Kawahara K, Teduka K, Kawamoto Y, Yamamoto T, Ishiwata T, Naito Z 2011

[雑誌論文] Nestin in gastrointestinal and other cancers : Effects on cells and tumor angiogenesis.

Ishiwata T, Matsuda Y, Naito Z. 2011

[雑誌論文] Comparison of Fixation Methods for Preservation of Morphology, RNAs, and Proteins From Paraffin-embedded Human Cancer Cell-implanted Mouse Models.

Matsuda Y, Fujii T, Suzuki T, Yamahatsu K, Kawahara K, Teduka K, Kawamoto Y, Yamamoto T, Ishiwata T, Naito Z. 2011

[学会発表] Stem cell marker Nestin regulated the migration and invasion of pancreatic cancer cells.

Matsuda Y, Ishiwata T, Kawamoto M, Yamomoto T, Kawahara K, Teduka T, Peng W-X, Yamahatsu K, Korc M, Naito Z. 2010

[学会発表] Stem cell marker Nestin regulated the migration and invasion of pancreatic cancer cells

Matsuda Y, et al 2010

[学会発表] Nestin modulates the migration and invasion of pancreatic cancer cells by regulating actin and E-cadherin expression

Matsuda Y, et al 2010

[学会発表] Nestin modulates the migration and invasion of pancreatic cancer cells by regulating actin and E-cadherin expression.

Matsuda Y, Ishiwata T, Yamahatsu K, Kawamoto M, Yamamoto T, Kawahara K, Onda M, Nakazawa N, Korc M, Naito Z 2010