トップ研究者を探す全身老化指標としての血管老化

全身老化指標としての血管老化

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22659143
研究種目 挑戦的萌芽研究
研究分野 生物系
医歯薬学
内科系臨床医学
内科学一般(含心身医学)
研究機関 愛媛大学
代表研究者 小原 克彦
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 3,470,000 (直接経費 :2,900,000、間接経費 :570,000)
配分額(履歴) 2012年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
2011年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2010年度:1,000,000 (直接経費 :1,000,000、間接経費 :0)
キーワード 老年医学
老化指標
老化
血管スティフネス
フレイルティ
認知機能
サルコペニア
骨塩量
転倒リスク
プレ・フレイルティ
動脈スティフネス
サルコペニック肥満
重心動揺
起立性血圧変動
縦断研究
血管硬化
血管年齢
筋肉量減少(サルコペニア)
骨粗鬆症

研究成果

[雑誌論文] Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population. Diabetes.

Onuma H 2013

[雑誌論文] Synergistic influence of age and serum uric acid on blood pressure among community-dwelling Japanese women

Kawamoto R, Tabara Y, Kohara K, Kusunoki T, Abe M, Miki T 2013

[雑誌論文] Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients

Igase M, Kohara K, Igase K, Yamashita S, Fujisawa M, Katagi R, Miki T 2013

[図書] 高血圧診療のすべて

小原克彦 2013

[雑誌論文] Plasma Resistin Is Associated With Single Nucleotide Polymorphisms of a Possible Resistin Receptor, the Decorin Gene, in the General Japanese Population

Onuma H, Tabara Y, Kawamura R, Ohashi J, Nishida W, Takata Y, Ochi M, Nishimiya T, Kawamoto R, Kohara K, Miki T, Osawa H 2013

[学会発表] Arterial aging and sarcopenia

Kohara K 2013

[雑誌論文] Hematological parameters are associated with metabolic syndrome in Japanese community-dwelling persons.

Kawamoto R 2013

[雑誌論文] Synergistic influence of age and serum uric acid on blood pressure among community-dwelling Japanese women.

Kawamoto R 2013

[雑誌論文] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia

Nakayama K, Ogawa A, Miyashita H,Tabara Y, Igase M, Kohara K,Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S 2013

[雑誌論文] Deep cerebral microbleeds are negatively associated with HDL-C in elderly first-time ischemic stroke patients.

Igase M 2013

[図書] ポリピル、高血圧療法における併用療法

小原克彦、檜垣実男編 2012

[学会発表] 愛媛大学抗加齢ドック受診者からみた認知機能と動脈硬化指数シンポジウム4脳血管認知症の原因と治療

小原克彦 2012

[学会発表] サルコペニアの臨床.エイジングサイエンスと抗加齢医学・医療

小原克彦 2012

[雑誌論文] Hunting for genes for hypertension: the Millennium Genome Project for Hypertension

Tabara Y, Kohara K,Miki T 2012

[雑誌論文] Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects : JSHIPP study

Kido M, Kohara K, 他 2012

[雑誌論文] Potential utility of soluble p3-alcadeinα plasma levels as a biomarker for sporadic Alzheimer's disease.

Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T 2012

[雑誌論文] Liver enzyme and adipocytokine profiles are synergistically associated with insulin resistance: the J-SHIPP study

Uetani E, Tabara Y, Igase M, Kido T, Ochi N, Takita R, Kohara K,Miki T 2012

[雑誌論文] Potential utility of soluble p3-Alcadeina plasma levels as a biomarker for sporadic Alzheimer's disease

Kamogawa K, Kohara K, 他 2012

[雑誌論文] Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation

Kobayashi Y, Hirawa N, Tabara Y, Muraoka H, Fujita M, Miyazaki N, Fujiwara A, Ichikawa Y, Yamamoto Y, Ichihara N, Saka S, Wakui H, Yoshida SI, Yatsu K, Toya Y, Yasuda G, Kohara K,Kita Y, Takei K, Goshima Y, Ishikawa Y, Ueshima H, Miki T, Umemura S 2012

[雑誌論文] Central blood pressure and end-organ damage

Kohara K 2012

[雑誌論文] γ-Glutamyl Transferase and High-Molecular-Weight Adiponectin Levels Are Synergistically Associated with Metabolic Syndrome and Insulin Resistance in Community-Dwelling Persons

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Abe M 2012

[雑誌論文] Central blood pressure: Current status and future perspective

Kohara K 2012

[雑誌論文] Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia.

Igase M 2012

[学会発表] 緩徐な降圧の立場から.高齢者の最終降圧目標(収縮期)は.第35回高血圧学会

小原克彦、三木哲郎 2012

[雑誌論文] Predictive value of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio for the prevention of stroke recurrence in Japanese patients treated with rosuvastatin

Igase M, Kohara K, Katagi R, Yamashita S, Fujisawa M, Miki T 2012

[学会発表] Epidemiological Studies Suggest the Link between Sleep Disorders and Nonspecific Headache Including Chronic Headache

Nagai T, Kohara K,Tabara Y, Okada Y, Ochi M, Kido T, Uetani E, Kido M, Igase M, Miki T 2012

[学会発表] 起立性低血圧・食後性低血圧 シンポジウム

小原克彦 2012

[雑誌論文] Atherosclerotic indices for the prediction of cognitive impairment in a middle-aged to elderly general population: shimanami health promoting program study

Kohara K,Igase M, Tabara Y, Miki T 2012

[雑誌論文] Increased high-density lipoprotein cholesterol is associated with a high prevalence of pre-hypertension and hypertension in community-dwelling persons

Kawamoto R, Tabara Y, Kohara K, Miki T, Abe M, Kusunoki T. 2012

[図書] 高齢者の高血圧、今日の循環器疾患治療指針

小原克彦 井上博、許俊鋭、檜垣實男、代田浩之、筒井裕之 編集 2012

[図書] 今日の循環器疾患治療指針 第3版

小原克彦 2012

[雑誌論文] Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults.

Kawamoto R, Kohara K, Kusunoki T, Tabara Y, Abe M, Miki T. 2012

[学会発表] Thigh Muscle Mass Decline Was Associated Brain Small Vessel Diseases in Men; Possible Link between Sarcopenia and Dementia.

Ochi M, Kohara K,Tabara Y, Takita R, Nagai T, Shinohara N, Okada Y, Ochi H, Igase M, Miki T 2012

[雑誌論文] Perceived age of facial features is a significant diagnosis criterion for age-related carotid atherosclerosis in Japanese subjects: J-SHIPP study

Kido M, Kohara K, Miyawaki S, Tabara Y, Igase M, Miki T. 2012

[学会発表] 栄養評価.指定演題

小原克彦 2012

[雑誌論文] Arterial stiffness and general aging: mini-review and hypothesis

Kohara K, Tabara Y, Igase M, Miki T 2012

[雑誌論文] Postprandial hypertension, an overlooked risk marker for arteriosclerosis

Uetani E, Tabara Y, Igase M, Guo H, Kido T, Ochi N, Takita R, Kohara K,Miki T 2012

[学会発表] 認知症と生活習慣病の不思議な関係

小原克彦 2012

[雑誌論文] Arterial stiffness in sarcopenic visceral obesity in the elderly: J-SHIPP study

Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T 2012

[学会発表] 起立性低血圧、食後性低血圧.シンポジウム 1 血圧そのものを徹底的に理解する

小原克彦 2012

[図書] Advances in Medicine and Biology

Kohara K, 他 2012

[雑誌論文] Central blood pressure and end-organ damage

Kohara K 2012

[雑誌論文] rterial stiffness in sarcopenic visceral obesity in the elderly : J-SHIPP study

Kohara K, 他 2012

[学会発表] Thigh Muscle Mass Decline Was Associated Brain Small Vessel Diseases in Men; Possible Link between Sarcopenia and Dementia.

Kohara K 2012

[雑誌論文] A Slightly Low Hemoglobin Level Is Beneficially Associated with Arterial Stiffness in Japanese Community-Dwelling Women.

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Katoh T, Ohtsuka N, Takayama S, Abe M. 2012

[学会発表] サルコペニアの臨床 エイジングサイエンス・シンポジウム

小原克彦 2012

[学会発表] 高齢者の最終降圧目標 ディベート

小原克彦 2012

[学会発表] Epidemiological Studies Suggest the Link between Sleep Disorders and Nonspecific Headache Including Chronic Headache.

Kohara K 2012

[学会発表] Postprandial Hypertension, an Overlooked Risk Factor for Arterial Stiffness

Uetani E, Tabara Y, Igase M, Ochi N, Kido T, Miki T, Kohara K. 2011

[雑誌論文] Association between fasting plasma glucose and high-sensitivity C-reactive protein : gender differences in a Japanese community-dwelling population

Kawamoto R, Kohara K, 他 2011

[雑誌論文] Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M, Katoh T, Ohtsuka N. 2011

[雑誌論文] Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study)

Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Makino H, Kohara K, Miki T. 2011

[学会発表] Atherosclerotic indices for the presence of cognitive impairment in a general population: J-SHIPP Study

Kohara K,Tabara Y, Ochi M, Nagai T, Okada Y, Kamogawa K, Takita R, Kawano Y, Igase M, Miki T. 2011

[雑誌論文] Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults

Kawamoto R, Kohara K, 他 2011

[雑誌論文] Association of serum high molecular weight adeponectin and blood pressure among non-diabetic community-dwelling men

Kawamoto R, Kohara K, 他 2011

[雑誌論文] Association between fasting plasma glucose and high-sensitivity C-reactive protein: gender differences in a Japanese community-dwelling population

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, Abe M, Katoh T, Ohtsuka N 2011

[学会発表] Relatively Lower Central Aortic Pressure in Subjects with Impaired Insulin Sensitivity and Resistance : The Toon Health Study

Tabara Y, Kohara K, 他 2011

[学会発表] Arterial Stiffness Associates with Cognitive Impairment and Brain Atrophy : J-SHIPP Study

KidoM, Kohara K, 他 2011

[学会発表] Arterial Stiffness in Sarcopenic Obesity, the Common Form of Obesity in the Elderly : J-SHIPP Study

Kohara K, 他 2011

[学会発表] Mechanical stresses in the common carotid artery in patients with small vessel disease

Okada Y, Kohara K,Tabara Y, Nagai T, Igase M, Tetsuro Miki T 2011

[雑誌論文] Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes

Kohara K, Ochi M, Tabara Y, Nagai T, Igase M, Miki T 2011

[雑誌論文] Serum gamma-glutamyl transferase within its normal concentration range is related to the presence of impaired fasting glucose and diabetes among Japanese community-dwelling persons

Kawamoto R, Kohara K, 他 2011

[学会発表] Increased levels of soluble p3-Alcadeinαin plasma of patients with Alzheimer's disease.

Kamogawa K, Kohara K, Tabara Y, Ochi M, Nagai T, Takita R, Igase M, Miki T, Konno T, Hata S, Suzuki T 2011

[学会発表] Arterial Stiffness Associates with Cognitive Impairment and Brain Atrophy: J-SHIPP Study

Kido M, Kohara K,Tabara Y, Kido T, OkadaY, Ochi M, Nagai T, Igase M, Miki T. 2011

[雑誌論文] Tanigawa T.Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance:the Toon Health Study

Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T 2011

[学会発表] Relatively Lower Central Aortic Pressure in Subjects with Impaired Insulin Sensitivity and Resistance: The Toon Health Study

Tabara Y, Saito I, Nishida W, Kohara K,Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T 2011

[雑誌論文] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance : the Toon Health Study

Tabara Y, Kohara K, 他 2011

[学会発表] 全身老化指標としての脈波伝搬速度.シンポジウムI アンチエイジングからみた高血圧研究

小原克彦、田原康玄、伊賀瀬道也、三木哲郎 2011

[図書] 頸動脈エコー、脂質異常症・肥満 動脈硬化、荻原俊男 監修.

小原克彦 2011

[学会発表] Arterial Stiffness in Sarcopenic Obesity, the Common Form of Obesity in the Elderly: J-SHIPP Study.

Kohara K,Tabara Y, Ochi M, Nagai T, Igase M, Miki T 2011

[学会発表] Increased levels of soluble p3-Alcadeinain plasma of patients with Alzheimer's disease

KamogawaK、Kohara K, 他 2011

[雑誌論文] The association between blood pressure and cognitive function

Igase M, Kohara K, 他 2011

[学会発表] Mechanical stresses in the common carotid artery in patients with small vessel disease

Okada Y、Kohara K, 他 2011

[雑誌論文] Hemoglobin is associated with serum high molecular weight adiponectin in Japanese community-dwelling persons

Kawamoto R, Kohara K, 他 2011

[学会発表] Atherosclerotic indices for the presence of cognitive impairment in a general population : J-SHIPP Study

Kohara K, 他 2011

[雑誌論文] Serum high molecular weight adiponectin correlates with arterial stiffness in community-dwelling persons

Kawamoto R, Kohara K, 他 2011

[学会発表] 中心血圧測定の可能性と限界.シンポジウムII 高血圧診療とNew Technology

小原克彦、田原康玄、伊賀瀬道也、三木哲郎 2011

[学会発表] Leptin In Sarcopenic Obesity : Possible Link Between Adipocyte And Myocyte.

Kohara K 2010

[雑誌論文] Global Blood Pressure Genetics Consortium, Umemura S, Ueshima H, Miki T. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P 2010

[雑誌論文] 血圧変動が大きい場合.専門医へのコンサルテーションを考慮すべきケース

小原克彦 2010

[雑誌論文] Alcohol drinking status is associated with serum high molecular weight adiponectin in community-dwelling Japanese men

Kawamoto R, Tabara Y, Kohara K, Miki T, Ohtsuka N, Kusunoki T, Abe M 2010

[雑誌論文] A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population

Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H. 2010

[雑誌論文] 降圧薬の合剤療法

小原克彦 2010

[雑誌論文] Serum high molecular weight adiponectin is associated with mild renal dysfunction in Japanese adults.

Kawamoto R, Tabara Y, Kohara K, Miki T, Abe M, Kusunoki T, Katoh T, Ohtsuka N. 2010

[雑誌論文] 動脈硬化

小原克彦 2010

[雑誌論文] Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men

Ochi M, Kohara K, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T 2010

[雑誌論文] Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study

Kamogawa K, Kohara K,Tabara Y, Uetani E, Nagai T, Yamamoto M, Igase M, Miki T 2010

[雑誌論文] 低血圧

小原克彦 2010

[雑誌論文] Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population

Ochi M, Tabara Y, Kido T, Uetani E, Ochi N, Igase M, Miki T, Kohara K 2010

[雑誌論文] Association of four genetic loci with uric acid levels and reduced renal function: The J-SHIPP Suita study

Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T 2010

[雑誌論文] Smoking Status is Associated with Serum High Molecular Adiponectin Levels in Community-Dwelling Japanese Men.

Kawamoto R, Tabara Y, Kohara K,Miki T, Ohtsuka N, Kusunoki T, Abe M 2010

[雑誌論文] Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study.

Kido T, Tabara Y, Igase M, Uetani E, Ochi N, Miki T, Kohara K 2010

[雑誌論文] 老年者高血圧の管理は?

小原克彦 2010

[雑誌論文] Association of central systolic blood pressure with intracerebral small vessel disease in Japanese

Ochi N, Kohara K, Tabara Y, Nagai T, Kido T, Uetani E, Ochi M, Igase M, Miki T. 2010

[学会発表] Clinical usefulness of second peak of radial SBP (SBP2) for an estimate of central SBP and its clinical application.

Kohara K 2010

[雑誌論文] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H 2010

[学会発表] 認知機能と動脈硬化指数 シンポジウム

小原克彦