初期発生におけるAIREの役割と自己寛容

トップ›研究者を探す›初期発生におけるAIREの役割と自己寛容

代表研究者	松本満
研究課題番号	KAKENHI-PROJECT-22659097
研究種目	挑戦的萌芽研究
研究分野	生物系医歯薬学基礎医学免疫学
研究機関	徳島大学
研究期間開始年月日	2010/4/1
研究期間終了年度	2011
研究ステータス	完了 (2011/4/1)
配分額（合計）	3,120,000 (直接経費 :2,700,000、間接経費 :420,000)
配分額（履歴）	2011年度：1,820,000 (直接経費 :1,400,000、間接経費 :420,000) 2010年度：1,300,000 (直接経費 :1,300,000、間接経費 :0)
キーワード	AIRE 自己免疫疾患 ES細胞初期胚ゼブラフィッシュ

研究成果

[学会発表] Role of self-antigen expressed by Aire-expressing cells in the negative selection process

Matsumoto, M., et al 2011

[雑誌論文] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking

Fukui, R., Saitoh, S.-I., Kanno, A., Onji, M., Shibata, T., Ito, A., Onji, M., Matsumoto, M., Akira, S., Yoshida, N., and Miyake, K. 2011

[雑誌論文] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

Matsumoto, M. 2011

[雑誌論文] Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T cell tolerance

Wada, N., Nishifuji, K., Yamada, T., Kudoh, J., Shimizu, N., Matsumoto, M., Peltonen, L., Nagafuchi, S., and Amagai, M. 2011

[学会発表] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

西嶋仁、毛利安宏、西川裕美子、松本満 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., Nishikawa, Y., Mouri, Y., and Nishijima, H 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance

Nishikawa, Y., Mouri, Y., Nishijima, H., and Matsumoto, M. 2011

[学会発表] Role of Aire in the organization of thymic microenvironment

Matsumoto, M., et al. 2011

[学会発表] Expression of Aire, a gene responsible for autoimmune disease, in ES cells

Matsumoto, M., et al 2011

[学会発表] Role of self-antigen expressed by Aire-expressing cells in the negative selection process

Matsumoto, M., Mouri, Y., Nishikawa, Y., and Nishijima, H 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., et al 2011

[学会発表] egative selectionにおけるAire発現細胞由来自己抗原の役割

毛利安宏、西川裕美子、西嶋仁、松本満 2011

[雑誌論文] Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla

Matsumoto, M. 2011

[学会発表] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Nishikawa, Y., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M. 2011

[学会発表] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance

Matsumoto, M., et al 2011

[雑誌論文] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

Mouri, Y., Yano, M., Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J. M., Inoue, J., Akiyama, T., and Matsumoto, M. 2011

[雑誌論文] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

Nishikawa, Y., Hirota, F., Yano, M., Kitajima, H., Miyazaki, J-i., Kawamoto, H., Mouri, Y., and Matsumoto, M. 2010

[学会発表] Roles of thymic epithelial cells for the establishment of self-tolerance

Matsumoto, M. 2010

[学会発表] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation

Nishikawa, Y., Mouri, Y., and Matsumoto, M. 2010

[学会発表] AIRE and autoimmune disease

Matsumoto, M., Nishikawa, Y., Hirota, F. and Mouri, Y. 2010

[学会発表] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes

Mouri, Y., Nishikawa, Y., and Matsumoto, M. 2010