トップ研究者を探すFGFR2IIIcアイソフォームの制御による膵臓癌の治療戦略

FGFR2IIIcアイソフォームの制御による膵臓癌の治療戦略

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22591531
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
外科系臨床医学
消化器外科学
研究機関 日本医科大学
代表研究者 石渡 俊行
連携研究者 内藤 善哉
連携研究者 松田 陽子
連携研究者 山本 哲志
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 4,290,000 (直接経費 :3,300,000、間接経費 :990,000)
配分額(履歴) 2012年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2011年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
2010年度:1,300,000 (直接経費 :1,000,000、間接経費 :300,000)
キーワード FGFR-2 IIIc
ESRP1
siRNA
癌幹細胞
選択的スプライシング
線維芽細胞増殖
因子受容体
線維芽細胞増殖因子受容体
FGFR2IIIc
細胞増殖因子受容体
FGFR2 IIIc
ESRP-1

研究成果

[雑誌論文] Expression, roles, and potential as a novel molecular target for colorectal cancer.

Matsuda Y, Ueda J, Ishiwata T. 2013

[雑誌論文] Nestin regulates epithelial-mesenchymal transitionmarker expression in pancreatic ductal adenocarcinoma cell lines.

Hagio M, Matsuda Y, Suzuki T, Ishiwata T 2013

[雑誌論文] Fibroblast Growth Factor Receptor2 IIIc as a Therapeutic Target for Colorectal Cancer Cells.

Matsuda Y, Hagio M, Seya T, IshiwataT 2012

[雑誌論文] Secreted 70 kiloDalton lumican stimulates growthand inhibits invasion of human pancreatic cancer.

Yamamoto T, Matsuda Y, Kawahara K, Ishiwata T, Naito Z 2012

[雑誌論文] Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer.

Cho K, Matsuda Y, Ueda J, Uchida E, Naito Z, Ishiwata T 2012

[雑誌論文] Keratinocyte growth factor stimulates growth of MIA PaCa-2 cells through extracellular signal-regulated kinase phosphorylation.

Yamamoto T, Matsuda Y, Kawahara K, Naito Z, Ishiwata T. 2012

[学会発表] 浸潤性膵癌におけるESRP1の発現と転移および予後との関連の検討

上田 純志、松田 陽子、内田 英二、山初 和也、内藤 善哉、石渡 俊行 2012

[雑誌論文] Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation.

Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z 2012

[雑誌論文] Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis

Yamahatsu K, Matsuda Y, Ishiwata T, Uchida E, Naito Z 2012

[雑誌論文] Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells.

Matsuda Y, Hagio M, Seya T, Ishiwata T. 2012

[学会発表] 浸潤性膵管癌組織におけるESRP1 とFGFR2 の発現と役割の検討

上田 純志、松田 陽子、山初 和也、内田 英二、内藤 善哉、石渡 俊行 2012

[学会発表] Inhibitory effects of fibroblast growth factor receptor 2 in pancreatic cancer.

Ishiwata T, Yoshimura H, Naito Z, Uchida E, Korc M, Matsuda Y 2012

[雑誌論文] Expression ofCancer Stem Cell Markers in Pancreatic Intraepithelial Neoplasias and Pancreatic Ductal Adenocarcinomas.

Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T 2012

[雑誌論文] Keratinocyte growth factor induces matrix metalloprotemase-9 expression and correlates with venous invasion in pancreatic cancer

Cho K, Matsuda Y, Ueda J, Uchida E, Naito Z, Ishiwata T 2012

[雑誌論文] Expression of cancer stem cell markers in pancreatic intraepithelial neoplasias and pancreatic ductal adenocarcinomas.

Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T. 2012

[雑誌論文] Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis.

Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T. 2011

[雑誌論文] Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis.

Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T 2011

[雑誌論文] Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas.

Ishiwatao T, Teduka K, Yamamoto T, Kawahara K, Matsuda Y, Naito Z 2011

[雑誌論文] Comparison of Fixation Methods for Preservation of Morphology, RNAs, and Proteins From Paraffin-embedded Human Cancer Cell-implanted Mouse Models.

Matsuda Y, Fujii T, Suzuki T, Yamahatsu K, Kawahara K, Teduka K, Kawamoto Y, Yamamoto T, Ishiwata T, Naito Z. 2011

[学会発表] 線維芽細胞増殖因子受容体(FGFR2 IIIc)を標的とした膵癌治療法の研究

石渡俊行、松田陽子、山本哲志、河本陽子、川原清子、恩田宗彦、内田英二、内藤善哉 2010

[学会発表] Fibroblast growth factor receptor (FGFR) 2 IIIc, is a novel molecular target for suppressing pancreatic cancer cell growth and migration

Ishiwata T, Matsuda Y, Kawahara K, Yamamoto T, Teduka K, Uchida E, Korc M, Naito Z 2010

[雑誌論文] Clinicopathological Features of Thirty Autopsy Cases of Pancreatic Carcinoma

Matsuda Y, Hagio M, Naito Z, Ishiwata T

[雑誌論文] Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation

Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z

[雑誌論文] Nestin and other putative cancer stem cell markers in pancreatic cancer

Matsuda Y, Kure S, Ishiwata T

[雑誌論文] Secreted 70 kDa lumican stimulates growth and inhibits invasion of human pancreatic cancer

Yamamoto T, Matsuda Y, Kawahara K, Ishiwata T, Naito Z