トップ研究者を探すダブルノックアウトマウスを利用したアトピー性皮膚炎モデルマウスの作製

ダブルノックアウトマウスを利用したアトピー性皮膚炎モデルマウスの作製

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22591240
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
皮膚科学
研究機関 香川大学
代表研究者 米田 耕造
研究分担者 窪田 泰夫
研究分担者 荒木 伸一
研究分担者 中井 浩三
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2013
研究ステータス 完了 (2013/4/1)
配分額(合計) 5,200,000 (直接経費 :4,000,000、間接経費 :1,200,000)
配分額(履歴) 2013年度:520,000 (直接経費 :400,000、間接経費 :120,000)
2012年度:390,000 (直接経費 :300,000、間接経費 :90,000)
2011年度:390,000 (直接経費 :300,000、間接経費 :90,000)
2010年度:3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
キーワード ロリクリン
ノックアウトマウス
魚鱗癬
アトピー性皮膚炎
バリア
フレーキーテールマウス
フィラグリン

研究成果

[雑誌論文] Novel ATP2A2 mutation in a patient with Darier disease

Yoneda K, Demitsu T and Kubota Y 2014

[雑誌論文] Multi-branched acquired periungual fibrokeratoma

Moriue T, Yoneda K, Moriue J, Nakai K and Kubota Y 2014

[雑誌論文] Detection of apoptotic keratinocytes in a case of bullous pemphigoid developed after graft-versus-host disease

Yoneda K, Demitsu T, Kakurai M, Narita T, Nakai K, Kubota Y, Ishii N and Hashimoto T 2014

[雑誌論文] Two cases of nevus sebaceous accompanying secondary tumors with Klothov expression

Nakai K, Yoneda K, Haba R, Kushida Y, Katsuki N, Moriue J, Moriue T, Ishikawa E, Inoue S and Kubota Y 2014

[雑誌論文] A survey of the factors associated with concerns about oral antihistamine use in Japanese pruritic 30. Hosokawa Y, Yoneda K, Nakai K, Moriue J and Kubota Y: Completely thrombosed venous aneurysm in great saphenous vein

Moriue J, Yoneda K, Nakai K, Hosokawa Y, Moriue T, and Kubota Y 2013

[雑誌論文] Successful treatment of primary cutenous anaplastic large cell lymphoma with intralesional methotrexate therapy

Yokoi I, Ishikawa E, Koura A, Hosokawa Y, Tamai A, Nakai K, Moriue J, Moriue T, Yoneda K and Kubota Y 2013

[雑誌論文] Dexamethasone induces caveolin-1 in vascular endothelial cells: implications for attenuated responses to VEGF

Igarashi J, Hashimoto T, Shoji K, Yoneda K, Tsukamoto I, Moriue T, Kubota Y and Kosaka H 2013

[雑誌論文] Deranged epidermal differentiation in kl/kl mouse and the effects of Klotho siRNA on the differentiation of HaCaT cells

Nakai K, Yoneda K, Haba R, Kushida Y, Katsuki N, Moriue T, Kosaka H, Kubota Y and Inoue S 2013

[雑誌論文] Primary dermal melanoma latent for more than 10 years

Moriue J, Yoneda K, Moriue T, Nakai K, Katsuki N, Haba R, Ikeda M and Kubota Y 2013

[雑誌論文] Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro

Moriue T, Igarashi J, Yoneda K, Hashimoto T, Nakai K, Kosaka H and Kubota Y 2013

[学会発表] Klotho regulates the differentiation and tumorgenesis of epidermal keratinocytes

Nakai K, Inoue S, Haba R, Kushida Y, Katsuki N, Hosokawa Y, Moriue T, Yoneda K and Kubota Y 2012

[雑誌論文] The profilaggrin N-terminal domain is absent in pityriasis rotunda

Yoneda K, Presland RB, Demitsu T, Shimizu T and Kubota Y 2012

[雑誌論文] Primary cutaneous cryptococcosis in a patient with CREST syndrome

Ishikawa E, Yoneda K, Nakai K, Moriue J, Yokoi I, Munehiro A and Kubota Y 2012

[雑誌論文] Pustular psoriasis precipitated by cytomegalovirus infection

Yoneda K, Matsuoka-Shirahige Y, Demitsu T and Kubota Y 2012

[雑誌論文] Interaction of the profilaggrin N-terminal domain with loricrin in human cultured keratinocytes and epidermis

Yoneda K, Nakagawa T, Lawrence OT, Huard J, Demitsu T, Kubota Y and Presland RB 2012

[学会発表] Cytomegalovirus infection is one of the precipitating factors for pustular psoriasis

Yoneda K, Matsuoka-Shirahige Y, Demitsu T and Kubota Y 2012

[雑誌論文] Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris

Kubota Y, Munehiro A, Shirahige Y, Nakai K, Katsuura J, Moriue T, Murakami Y, Matsunaka H and Yoneda K 2012

[雑誌論文] Juvenile xanthogranuloma with lichenoid appearance

Yoneda K, Demitsu T and Kubota Y 2012

[雑誌論文] Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris

Munehiro A, Murakami Y, Shirahige Y, Nakai K, Moriue T, Matsunaka H, Yoneda K and Kubota Y 2012

[雑誌論文] Pinch and ligation method: a new non-surgical approach to viral warts

Moriue T, Yoneda K, Moriue J, Nakai K, Yokoi I, Fujita N, Munehiro A, Maeda R and Kubota Y 2012

[雑誌論文] Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies

Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H and Kubota Y 2012

[雑誌論文] Numerous mucin nodules in a patient with seropositive wide spread discoid lupus erythematosus

Yoneda K, Moriue J, Nakai K, Demitsu T, Moriue T, Yokoi I, Munehiro A, Dobashi H and Kubota Y 2012

[雑誌論文] Scedosporium apiospermum skin infection mimicking tuberous xanthoma

Yoneda K, Nakai K, Moriue T, Ishikawa E, Demitsu T, Ohkusu K and Kubota Y 2012

[雑誌論文] Macular lymphocytic arteritis in a patient with rheumatoid arthritis

Munehiro A, Yoneda K, Koura A, Nakai K and Kubota Y 2012

[雑誌論文] Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.

Nakai K 2012

[学会発表] Reduced expression of EGF receptor, E-cadherin and occludin is due to loricrin deficiency in the skin of flaky tail mice

Nakai K, Yoneda K, Hosokawa Y, Moriue T and Kubota Y 2011

[学会発表] Direct effects of bevacizumab on cell proliferation and cell signaling pathways in HaCaT cells

Hosokawa Y, Yoneda K, Moriue T, Nakai K and Kubota Y 2011

[雑誌論文] Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice

Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y 2011

[雑誌論文] Skin infiltration of pelvic actinomycosis after total gastrectomy

Yoneda K, Nakai K, Hosokawa Y, Moriue T, Demitsu T and Kubota Y 2011

[雑誌論文] Unilateral palm pompholyx in a patient with amyotrophic lateral sclerosis

Nakai K, Yoneda K, Moriue T, Hosokawa Y, Yokoi I and Kubota Y 2011

[学会発表] The profilaggrin N-terminal domain is absent in pityriasis rotunda

Yoneda K, Presland RB, Demitsu T, Shimizu T and Kubota Y 2011

[雑誌論文] Sarcoidosis presenting transepidermal elimination

Yoneda K, Kakurai M, Umemoto N, Nakai K, Kubota Y and Demitsu T 2011

[学会発表] Pitavastatin suppresses lipid peroxidation-induced VEGF expression in the skin of KKAy metabolic syndrome mice

Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y 2010

[雑誌論文] Late radiation dermatitis of the right arm after cardiac catheterization

Yoneda K, Nakai K, Demitsu T, Moriue T, Moriue J, Yokoi I, Munehiro A, Noma T, Kohno M and Kubota Y 2010

[雑誌論文] Bevacizumab-induced hand-foot syndrome: circumscribed type

Munehiro A, Yoneda K, Nakai K, Demitsu T, Moriue T, Moriue J, Yokoi I, Fujita N, Matsuura N, Ishikawa S, Yokomise H and Kubota Y 2010

[雑誌論文] Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes

Yoneda K, Demitsu T, Manabe M, Igarashi J, Kosaka H, Inagaki N, Takahashi H, Kon A, Kakurai M and Kubota Y 2010

[雑誌論文] Seborrhoeic keratoses and acanthosis nigricans in a long-term survivor of thanatophoric dysplasia

Nakai K, Yoneda K, Moriue T, Munehiro A, Fujita N, Moriue J, Yokoi I, Haba R, Itoh S and Kubota Y 2010

[学会発表] The effects of oxidized LDL on VEGF production in HaCaT cells: a possible mechanism for psoriasis in metablic syndrome

Nakai K, Yoneda K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y 2010

[雑誌論文] Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma

Yoneda K, Demitsu T, Nakai K, Moriue T, Ogawa W, Igarashi J, Kosaka H and Kubota Y 2010

[学会発表] Abnormally aggregated caveolin-1 in the cytoplasm of cellular model of classic Vohwinkel syndrome

Yoneda K, Nakai K, Moriue T, Demitsu T and Kubota Y 2010

[雑誌論文] Community-based epidemiological study of psychosocial effects of acne in Japanese adolescents

Kubota Y, Shirahige Y, Nakai K, Katsuura J, Moriue T and Yoneda K 2010

[雑誌論文] Zosteriform cutaneous metastasis of lung adenocarcinoma

Kubota Y, Nakai K, Munehiro A, Moriue J and Yoneda K