トップ研究者を探す先天性心疾患の責任遺伝子の同定と心臓幹細胞を用いた機能解析

先天性心疾患の責任遺伝子の同定と心臓幹細胞を用いた機能解析

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22591181
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
内科系臨床医学
小児科学
研究機関 愛媛大学
代表研究者 檜垣 高史
研究分担者 江口 真理子
研究分担者 江口 峰斉
研究分担者 鹿田 文昭
連携研究者 鹿田 文昭
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 4,160,000 (直接経費 :3,200,000、間接経費 :960,000)
配分額(履歴) 2012年度:1,560,000 (直接経費 :1,200,000、間接経費 :360,000)
2011年度:1,170,000 (直接経費 :900,000、間接経費 :270,000)
2010年度:1,430,000 (直接経費 :1,100,000、間接経費 :330,000)
キーワード 小児循環器学
先天性心疾患
遺伝子異常
FLK1陽性細胞
心筋
MLPA法

研究成果

[学会発表] Acute Coronary Syndrome in Adults with a History of Kawasaki Disease : A Japanese Nationwide Survey

Mitani Y, Tsuda E, Kato H, Ogawa S, Fujiwara Y, Nakamura Y, Takahashi K, Ayusawa M, Kobayashi T, Ichida F, Matsushima M, Kamata M, Higaki T, Suda K, Ohashi H, Yokoi H, Hamaoka K 2012

[学会発表] Role of therapeutic catheterization to support pediatric cardiology in developing country

Tomita H, Haneda N, Higaki T, Kataoka K 2012

[図書] 洞不全症候群 (sick sinus syndrome, SSS)、今日の小児治療指針 第15版

檜垣高史 2012

[学会発表] Successful stent implantation for pulmonary venous drainage route in the patients with single ventricle complicated by total anomalous pulmonary venous connection

Higaki T, Mori Y, Yamamoto E, Nakano T, Ohta M, Takata H, Chisaka T, Moritani T, Miyata T, Yamauchi T, Nakashima Y, Takeda Syo, Kitazawa H, Nagashima M, Okamura T, Shikata F, Ishii E 2012

[学会発表] Pre-event Course of Culprit Lesions in Acute Coronary Syndrome in Adults with a History of Kawasaki Disease: A Japanese Nationwide Survey

Mitani Y, Tsuda E, Kato H, Ogawa S, Fujiwara M, Nakamura Y, Takahashi K, Ayusawa M, Kobayashi T, Ichida F, Satoh F, Matsushima M, Kamata M, Kamata M, Higaki T, Suda K, Ohashi H, Yokoi H, Hamaoka K 2012

[雑誌論文] 小児循環器診療 集約化と地域での分業のバランス―地方都市の小児循環器医として―

檜垣高史 2012

[学会発表] Coil embolization of congenital portosystemic shunt(a left gastric vein-left renal vein shunt)

Yamamoto E, Higaki T, Takata H, Ohta M, Chisaka T, Moritani T, Tanaka H, Ishii E. 2012

[学会発表] Aortography with Balloon Occlusion of Tricuspid Valve in a Patient with Pulmonary Atresia and Sinusoidal Communication

Takata H, Higaki T, Yamamoto E, Ohta M, Chisaka T, Tashiro R, Ishii E. 2012

[学会発表] 成人先天性心疾患 社会保障と保険

檜垣高史 2012

[学会発表] Noncompaction of Myocardium in Neonate

Takata H, Higaki T, Yamamoto E, Konishi K, Ohta M, Chisaka T, Nagashima M, Okamura T, Shikata F, Ishii E 2012

[学会発表] Long-term Monitoring of Clinical Outcomes in Kawasaki Disease Patients with Giant Coronary Aneurysms

Higaki T, Yamamoto E, Takata H, Ohta M, Chisaka T, Moritani T, Miyata T, Konishi K, Horikawa S, Ishii E 2012

[雑誌論文] Life-threatening acute renal failure due to imperforate hymen in an infant

Nagai, K., Y. Murakami, K. Nagatani, N. Nakahashi, M. Hayashi, T. Higaki and E. Ishii 2012

[雑誌論文] Novel dominant-negative mutant of GATA3 in HDR syndrome

Ohta, M., M. Eguchi-Ishimae, M. Ohshima, H. Iwabuki, K. Takemoto, K. Murao, T. Chisaka, E. Yamamoto, T. Higaki, K. Isoyama, M. Eguchi and E. Ishii 2011

[雑誌論文] Total anomalous pulmonary venous drainage complicated by tracheoesophageal fistula

Okamura, T., M. Nagashima, F. Shikata, T. Higaki, E. Yamamoto, M. Ohta and H. Takata. 2011

[雑誌論文] Long-term outcome of coil occlusion in patients with patent ductus arteriosus

Takata, H., T. Higaki, H. Sugiyama, M. Kitano, E. Yamamoto, T. Nakano, M. Nagashima, F. Shikata, H. Tomita, S. Yazaki, I. Shiraishi and E. Ishii 2011

[雑誌論文] Pulmonary artery banding for neonates and early infants with low body weight.

Nagashima, M., T. Okamura, F. Shikata, T. Chisaka, H. Takata, M. Ohta, E. Yamamoto and T. Higaki. 2011

[雑誌論文] Asynchronous contraction of the 2 ventricles caused by ventricular pacing after a Fontan-type operation in a patient with a biventricular heart

Higaki T 2011

[学会発表] 成人期川崎病既往者における急性冠症候群の実態

檜垣高史 2011

[学会発表] Acute Coronary Syndrome in Adults with a History of Kawasaki Disease: A Japanese Nationwide Survey

Mitani Y, Tsuda E, Kato H, Ogawa S, Nakamura Y, Takahashi K, Ayusawa M, Kobayashi T, Ichida F, Matsushima M, Kamata M, Higaki T, Suda K, Ohashi H, Yokoi H, Hamaoka K 2011

[学会発表] Out-Of-Hospital Cardiac Arrest in Elementary and Middle School Students in the Era of Public-Access Defibrillation: ARetrospective, Nationwide, Hospital-Based Survey in Japan

Mitani Y, Ohta K, Ichida F, Nii M, Sawada H, Ohashi H, Yodoya N, Otsuki S, Arakaki Y, Ushinohama H, Tateno S, Sato S, Suzuki T, Higaki T, Iwamoto M, Yoshinaga M, Sumitomo N 2011

[学会発表] アンデルセン症候群の現状と治療

檜垣高史 2011

[学会発表] Evaluation of the Modified Blalock-Taussig Shunt in Children with Congenital Heart Disease Using 64-slice and 256-slice Computed Tomography

Higaki Takashi 2010

[雑誌論文] The use of a handmade balloon-expandable covered stent for native coarctation of the aorta in an adult patient : A report of a first case in Japan

Higaki Takashi 2010

[雑誌論文] Two-stage surgical repair for truncus arteriosus with unilateral absence of the left proximal pulmonary artery:translocation of the left pulmonary artery to the right pulmonary artery

Nagashima, M., N. Hibino, Y. Seike, M. Ohta, E. Yamamoto and T. Higaki 2010

[学会発表] Impact Of Public-Access Defibrillation At School On The Outcome After Out-Of-Hospital Cardiac Arrest Of Cardiac Origin In Elementary And Middle School Students: A Japanese Nationwide Survey

Mitani Y, Ohta K, Ichida F, Nii M, Arakaki Y, Ushinohama H, Ohashi H, Tateno S, Sato S, Suzuki T, Higaki T, Iwamoto M, Yoshinaga M, Sumitomo N 2010

[雑誌論文] Use of a hand-made balloon-expandable covered stent for native coarctation of the aorta in an adult patient: a report of a first case in Japan

Higaki, T., E. Yamamoto, M. Ryugo, H. Imagawa, F. Shikata, M. Nagashima, M. Ohta, H. Takata, K. Murao, T. Chisaka, T. Moritani, R. Watanabe, H. Tomita, K. Kawachi and E. Ishii 2010

[雑誌論文] Cardiac thrombus associated with Mycoplasma pneumoniae infection.

Nagashima, M., T. Higaki, H. Satoh and T. Nakano. 2010

[学会発表] 小児期におけるアンデルセン症候群の実態調査:全国調査

檜垣高史 2010

[学会発表] Change In The Qt Intervals During Infantile Periods

Yoshinaga M, Kato Y, Nomura Y, Hazeki D, Yasuda T, Takahashi K, Higaki T, Tanaka Y, Suruki N, Wada A, Horigome H, Ueno K, Suzuki H, Nagashima M. 2010

[雑誌論文] A case of pulmonary stenosis after a repair for tetralogy of Fallot treated with percutaneous pulmonary valvuloplasty using a triple-balloon technique

Fujii, A., J. Funada, N. Morioka, H. Hashida, T. Iwata and T. Higaki 2010

[雑誌論文] Occlusion of the right coronary artery ostium by an aortic cusp attachment.

Shikata, F., M. Nagashima, T. Higaki and K. Kawachi 2010

[雑誌論文] Asynchronous contraction of the 2 ventricles caused by ventricular pacing after a Fontan-type operation in a patient with a biventricular heart

Higaki Takashi 2010

[雑誌論文] Successful revascularization by pulse infusion thrombolysis in a patient with Kawasaki disease combined with acute myocardial infarction.

Inaba, S., T. Higaki, M. Nagashima, K. Nishimura, A. Ogimoto, J. Higaki and H. Okayama 2010

[雑誌論文] Anatomically corrected malposition of the great arteries with tubular hypoplasia of the aortic arch: a case report of surgical correction

Nagashima, M., S. Takano, E. Yamamoto and T. Higaki 2010

[雑誌論文] Anomalous subaortic left brachiocephalic vein in surgical cases and literature review

Nagashima, M., F. Shikata, T. Okamura, E. Yamamoto, T. Higaki, M. Kawamura, M. Ryugo, H. Izutani, H. Imagawa, S. Uchita, Y. Okamura, H. Suzuki, Y. Nakamura, O. Tagusari and K. Kawachi 2010

[雑誌論文] Successful stenting of the ductus venosus in 2 neonates with a splenia syndrome complicated with infracardiac type total anomalous pulmonary venous connection

Higaki Takashi 2010

[雑誌論文] Cervical aortic arch and Kommerell's diverticulum associated with the anomalous subaortic left brachiocephalic vein in a patient with chromosome 22q11.2 deletion

Nagashima, M., F. Shikata, T. Higaki and K. Kawachi. 2010

[学会発表] Evaluation of the Modified Blalock-Taussig Shunt in Children with Congenital Heart Disease Using 64-slice and 256-slice Computed Tomography

Higaki T, Kurata A, Yamamoto E, Matsuda O, Nakano T, Konishi K, Ohta M, Takata H, Nagatani K, Murao K, Takahashi Y, Chisaka T, Moritani T, Watanabe R, Nagashima M, Shikata F, Okamura T ,Hosokawa K, Kido T, Higashino H, Mochizuki T, Ishii E 2010

[学会発表] バルーン弁形成術-どのバルーンを選択するか?サイズは?-

檜垣高史 2010

[雑誌論文] Biventricular pacing in children with complete atrioventricular block.

Shikata, F., M. Nagashima and T. Higaki 2010

[雑誌論文] Cardiac surgery for a patient with Andersen-Tawil syndrome

Nagashima, M., T. Higaki, Y. Seike and Y. Yokoyama 2010

[学会発表] Successful stent implantation for pulmonary venous drainage route in the patients with single ventricle complicated by total anomalous pulmonary venous connection

檜垣高史