研究成果

[雑誌論文] SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitUmor activity against malignant pleural mesothelioma

Iwahori K, Serada S, Fujimoto M, Ripley B, Nomura S, Mizuguchi H, Shimada S, Takahashi T, Kawase I, Kishimoto T, Naka T 2013

[図書] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis. 潰瘍性大腸炎の疾患活動性マーカーとしての血清ロイシンリッチアルファ2グリコプロテインINTESTINE

工藤進英, 世良田聡, 藤本穣, 仲哲治, 他 2013

[図書] INTESTINE

工藤進英　 世良田聡 藤本穣 仲哲治　他 2013

[雑誌論文] Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease

Shinzaki S, Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy SE, Takehara T, Miyoshi E 2013

[雑誌論文] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer

Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T 2013

[雑誌論文] Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.

Shinzaki S, 他13名, Naka T, Plevy S E, Takehara T, Miyoshi E. 2013

[雑誌論文] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells

Souma Y, Nishida T, Serada S, Iwahori K, et al 2012

[雑誌論文] Serum HE4 as a diagnostic and prognostic marker for lung cancer

Iwahori K, Suzuki H, Kishi Y, Fujii Y, Uehara R, Okamoto N, Kobayashi M, Hirashima T, Kawase I, Naka T 2012

[学会発表] Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud’s Phenomenon.

Serada S, Fujimoto M, Naka T. 2012

[学会発表] PERIOSTIN, A NOVEL MATRICELLULAR PROTEIN, IS REQUIRED FOR CUTANEOUS SCLEROSIS IN A MOUSE MODEL OF SCLERODERMA

Yang L, Serada S, Fujimoto M, Murota H, Kotobuki Y, Kitaba S, Naka T, Katayama I. 2012

[学会発表] Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud' s Phenomenon

Serada S, Fujimoto M, Naka T 2012

[学会発表] UP-REGULATION OF INTERLEUKIN 8 AND CXC CHEMOKINE LIGAND 1 BY COLD STIMULATION IN HUMAN　DERMAL MICROVASCULAR ENDOTHELIAL CELLS: A ROLE IN WINTER ULCERATION AND COLD URTICARIA

Yang L, Murota H, Fujimoto M, Serada S, Yong M, Ohkawara T, Naka T, Katayama I. 2012

[雑誌論文] IL-6によるレギュラトリーT細胞の抑制:nTregとiTregの相違

藤本 穣、寺部 文隆、仲 哲治 2012

[雑誌論文] Dysregulation of Melanocyte Function by Th17-related Cytokines: Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris

Kotobuki Y, Tanemura A, Yang L, Itoi S, Kaneda M, Murota H, Fujimoto M, Serada S, Naka T Katayama I 2012

[雑誌論文] Periostin Facilitates Skin Sclerosis via PI3K/Akt Dependent Mechanism in a Mouse Model of Scleroderma

Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I 2012

[図書] 先端医療シリーズ43循環器疾患の最新医療

永井良三, 許俊鋭, 鄭忠和, 澤芳樹, 堀正二, 小川聡田, 林胱一, 佐野俊二, 天野篤, 筒井裕之, 小川久雄, 寺田弘司, 世良田聡, 仲哲治 2012

[図書] 先端医療シリーズ43　循環器疾患の最新医療

永井良三 許俊鋭 鄭忠和 澤芳樹 堀正二 小川聡 田林晄一 佐野俊二 天野篤 筒井裕之 小川久雄 寺田弘司 　　世良田聡　仲哲治 2012

[学会発表] INTERLEUKIN (IL)-6 DEFICIENCY DOES NOT AFFECT MOTOR NEURON DISEASE CAUSED BY SUPEROXIDE DISMUTASE 1 MUTATIONS

YONG MEI, Fujimoto M, Ohkawara T, Yang L, Serada S, Tsunoda S, Naka T. 2012

[雑誌論文] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts

Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanenlura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Narisawa Y,Katayama I, Izuhara K, Naka T 2012

[雑誌論文] Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord lnJury

Ishii H, Jin X, Ueno M, Tanabe S, Kubo, Serada S, Naka T. Yamashita T 2012

[雑誌論文] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells.

Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T. 2011

[雑誌論文] Dysregulation of Melanocyte Function by Th17-related Cytokines : Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris

Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I 2011

[学会発表] Tregの分化、機能におけるIL-6の作用

藤本穣、仲哲治 2011

[学会発表] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis

Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka 2011

[学会発表] Quantitative proteomic analysis of cell-surface membrane proteins : Biomarker discovery in endometrial cancer

Takuhei Yokoyama, Takayuki Enomoto, Satoshi Serada, Shinya Matsuzaki, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Kiyoshi Yoshino, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka 2011

[雑誌論文] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis

Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T 2011

[学会発表] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis

Serada S, Fujimoto M, Terabe F, Naka T 2011

[雑誌論文] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Chun Man Lee, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T 2011

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Not Only Thl7 But Also Interphotoreceptor Retinoid Binding Protein-Specific Thl By Promoting Regulatory T cells In Experimental Autoimmune Uveoretinitis.

Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T. 2011

[学会発表] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索

Satoshi Serada, Takuhei Yokoyama, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka 2011

[学会発表] SOCS-1, -3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of TAK/STAT and P38 MAPK signaling pathways

Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka 2011

[学会発表] PERIOSTIN GENE KNOCKOUT IS PROTECTIVE AGAINST THE DEVELOPMENT OF BLEOMYCIN-INDUCED MURINE SKIN SCLERODERMA

L.Yang, M.Fujimoto, S.Serada, H.Murota, B.Ripley, S.Kitaba, Y.Kotobuki, T.Naka, I.Katayama 2011

[学会発表] Periostin, a matricellular protein, accelerates wound repair by activating dermal fibroblasts

Yorihisa Kotobuki, Kanako Ontsuka, Satoshi Serada, Hiroshi Shiraishi, Atsushi Tanemura, Shoichiro Ohta, Lingli Yang, Tetsuji Naka, Kenji Izuhara, Ichiro Katayama 2011

[雑誌論文] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis

Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio 2011

[学会発表] MYD88 GENE KNOCKOUT INHIBITS THE DEVELOPMENT OF LUPUS-LIKE DISEASE IN NZB/W F1 MICE

T.Ohkawara, B.Ripley, M.Fujimoto, T.Naka 2011

[学会発表] NUCLEAR RECEPTOR PPAR-GAMMA NEGATIVELY REGULATES TYPE I INTERFERON PRODUCTION VIA INTERACTION WITH IRF7

B.Ripley, M.Fujimoto, S.Serada, L.-L.Yang, F.Terabe, Y.-M.Han, T.Ohkawara, T.Nishikawa, T.Naka 2011

[学会発表] TGFbeta1 promotes bleomycin-induced murine dermal sclerosis via its downstream molecule of periostin

Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T 2011

[学会発表] Nuclear receptor PPAR-gamma interacts with IRF7 to negatively regulate TLR7/9-mediated type I interferon production and the development of murine lupus

Ripley B, Fujimoto M, Han A, Millrine D, Lee S, Kawai T, Akira S, Naka T, Kishimoto T 2011

[学会発表] The effect of IL-6 overproduction on T helper cell differentiation in vivo

Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T 2010

[図書] 医学のあゆみサイトカインシグナル伝達抑制分子(SOCS)の新規抗癌剤としての応用

世良田聡,仲哲治 2010

[学会発表] The effect of IL-6 overproduction in vivo on wound healing. Cytokines in Infectious Diseases

Fujimoto M, Kotobuki Y, Ktaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T 2010

[学会発表] The effect of IL-6 overproduction in vivo on wound healing

Fujimoto M, Kotobuki Y, Kitaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T 2010

[学会発表] 自己免疫疾患の新規活動性マーカーとしての leucine rich alpha 2 glycoprotein Proteomics-based identification of leucine rich alpha 2 glycoprotein (LRG) as anovel biomarker associated with disease activity of inflammatory autoimmune disorders

世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, wahori K, Ohguro N, Kishimoto T, Naka T 2010

[学会発表] Blockade of IL-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Thl7 responses

Hohki S, Ohguro N, Haruta H, Terabe F, Serada S, Fujimoto M, Kishimoto T, Naka T 2010

[雑誌論文] Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Thl7 Responses.

Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T. 2010

[雑誌論文] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases

Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T 2010

[学会発表] Interleukin-6 blockade in CD4 T cells inhibits the development of experimental autoimmune uveitis

Haruta H, Ohguro N, Hohki S, Nishida K, Fujimoto M, Naka T 2010

[雑誌論文] SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases.

Fujimoto M, Naka T. 2010

[雑誌論文] Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression.

Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T 2010

[学会発表] SOCS-1,-3 GENE DELIVERY IN GASTRIC CANCER CELLS INDUCES A POTENT ANTI-PROLIFERATIVE EFFECT VIA THE SUPPRESSION OF JAK/STAT AND P38 MAPK SIGNALING PATHWAYS

Serada S, Souma Y, Nishida T, Fujimoto M, Naka T 2010

[学会発表] The deficiency of thymus fails to improve lethal inflammation in SOCS-1 knock-out mice

Ukita T, Fujimoto M, Yong mei, Kawabata H, Kishimoto T, Naka T 2010

[学会発表] The effect of IL-6 0verproduction on helper cell differentiation in vivo

Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishinloto T, Naka T 2010

[学会発表] 自己免疫疾患の新規活動性マーカーとしてのleucine rich alpha 2 glycoprotein Proteomics-based identification of leucine rich alpha 2 glycoprotein (LRG) as a novel biomarker associated with disease activity of inflammatory autoimmune disorders

世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治 2010

創傷治癒剤

膠原病に伴うレイノー症状を診断する方法及び診断用キット

膠原病に伴うレイノー症状を診断する方法及び診断用キット

結核検査用バイオマーカー

創傷治癒剤

結核検査用バイオマーカー