トップ研究者を探す酩酊による神経性因子および認知機能への影響-ノックアウトマウスによるモデル研究

酩酊による神経性因子および認知機能への影響-ノックアウトマウスによるモデル研究

KAKEN 科学研究費助成事業データベース で見る
研究課題番号 KAKENHI-PROJECT-22590636
研究種目 基盤研究(C)
研究分野 生物系
医歯薬学
社会医学
法医学
研究機関 香川大学
代表研究者 MOSTOFA Jamal
研究分担者 木下 博之
研究分担者 三木 崇範
研究分担者 飴野 清
研究期間 開始年月日 2010/4/1
研究期間 終了年度 2012
研究ステータス 完了 (2012/4/1)
配分額(合計) 4,810,000 (直接経費 :3,700,000、間接経費 :1,110,000)
配分額(履歴) 2012年度:650,000 (直接経費 :500,000、間接経費 :150,000)
2011年度:260,000 (直接経費 :200,000、間接経費 :60,000)
2010年度:3,900,000 (直接経費 :3,000,000、間接経費 :900,000)
キーワード Neurotrofic factor
Ethanol
Acetaldehyde
Knockout mice
Memory
エタノール
アセトアルデヒド
コリン作動性神経活動
海馬
Aldh2 ノックアウトマウス
ApoEノックアウトマウス
記憶
ニューロトロフィン
Neurotrophic factor
Eight arm radial maze
Morris water maze
空間認知
Aldhノックアウトマウス
ApoE-/-ノックアウトマウス

研究成果

[雑誌論文] High ethanol and acetaldehyde increase c-fos mRNA expression in the hippocampus of Aldh2- knockout mice

Mostofa Jamal, Kiyoshi Ameno, Takanori Miki, Ruby Sultana, Naoko Tanaka, Junichiro Ono, Yu Nakamura and Hiroshi Kinoshita 2013

[雑誌論文] High ethanol- and acetaldehyde-induced cholinergic imbalance in the hippocampus of Aldh2- knockout mice does not affect on mRNA levels of nerve growth factor and brain-derived neurotrophic factor

Mostofa Jamal, Kiyoshi Ameno, Takanori Miki, Naoko Tanaka, Mostofa Ruby, Yu Nakamura, Mitsuru Kumihashi and Hiroshi Kinoshita 2013

[雑誌論文] High ethanol and acetaldehyde increase c-fos mRNA expression in the hippocampus of Aldh2-knockout mice

Mostofa Jamal, Kiyoshi Ameno, Takanori Miki, Ruby Sultana, Naoko Tanaka, Junichiro Ono, Yu Nakamura and Hiroshi Kinoshita. 2013

[雑誌論文] High ethanol- and acetaldehyde-induced cholinergic imbalance in the hippocampus of Aldh2-knockout mice does not affect on mRNA levels of nerve growth factor and brain-derived neurotrophic factor

Mostofa Jamal, Kiyoshi Ameno, Takanori Miki, Naoko Tanaka, Mostofa Ruby, Yu Nakamura, Mitsuru Kumihashi and Hiroshi Kinoshita. 2013

[図書] Nova Science Publishers Inc., NY, USA (http://:www.novapublishers.com)

Mostofa Jamal, Kyioshi Ameno, Naoko Tanaka, Mitsuru Kumihashi, and Hiroshi Kinoshita 2012

[雑誌論文] Low-dose nicotine facilitates spatial memory in ApoE-knockout mice in the radial arm maze

Ruby Sultana, Kyioshi Ameno, Mostofa Jamal, Takanori Miki, Naoko Tanaka,Junichiro Ono, Hiroshi Kinoshita, Yu Nakamura 2012

[学会発表] Effects of nicotine on radial-arm maze spatial memory in Apo-E knockout mice

Mostofa Jamal, Ruby Sultana, Kiyoshi Ameno, Naoko Tanaka, Hiroshi Kinoshita, Yu Nakamura 2012

[学会発表] Brain ethanol and acetaldehyde formation, and their central effects in the brain of Aldh2-knockout mice

Mostofa Jamal, Kiyoshi Ameno, Naoko Tanaka, Matsuru Kumihashi, Hiroshi Kinoshita 2012

[雑誌論文] High ethanol and acetaldehyde impair spatial memory in mouse models: opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory

Mostofa Jamal, Kyioshi Ameno, Takanori Miki, Naoko Tanaka, Junichiro Ono, Gatoro Shirakami, Ruby Sultana, Yu Nakamura, Hiroshi Kinoshita 2012

[図書] Nicotine Addiction: Prevention,Healtheffects and Treatment options

Mostofa Jamal, Kyioshi Ameno, Naoko Tanaka, Mitsuru Kumihashi, and Hiroshi KinoshitaIn 2012

[雑誌論文] High ethanol and acetaldehyde impair spatial memory in mouse models: opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory

Mostofa Jamal, Kyioshi Ameno, Takanori Miki, Naoko Tanaka, Junitro Ono, Gatoro Shirakami, Ruby Sultana, Yu Nakamura, Hiroshi Kinoshita 2012

[学会発表] Effects of nicotine on radial-arm maze spatial memory in Apo-E knockout mice

Mostofa Jamal, Ruby Sultana, Kiyoshi Ameno, Naoko Tanaka, Hiroshi Kinoshita, Yu Nakamura 2012

[雑誌論文] High ethanol and acetaldehyde impair spatial memory in mouse models : Opposite effects of aldehyde dehydrogenase 2 and apolipoprotein E on memory

Jamal M 2012

[学会発表] Brain ethanol and acetaldehyde formation, and their central effects in the brain of Aldh2-knockout mice

Mostofa Jamal, Kiyoshi Ameno, Naoko Tanaka, Matsuru Kumihashi, Hiroshi Kinoshita 2012

[学会発表] Effects of ethanol and acetaldehyde on hippocampal c-fos and cholinergic expression in mice models.

Mostofa Jamal 2011

[学会発表] Acute effects of ethanol and acetaldehyde on hippocampal c-fos and cholinergic marker expression in mice models

Mostofa Jamal, et al 2011

[学会発表] Acute alcohol effects and role of acetaldehyde in memory in mice models

Mostofa Jamal 2010

[学会発表] Acute alcohol effects and role of acetaldehyde in memory in mice models

Mostofa Jamal 2010

[雑誌論文] Effects of systemic nicotine, alcohol or their combination on cholinergic markers in the frontal cortex and hippocampus of rat

Mostofa Jamal 2010

[学会発表] Acute alcohol exposure in mice models : impact on memory

Mostofa Jamal 2010

[学会発表] Acute alcohol exposure in mice models: impact on memory

Mostofa Jamal 2010

[学会発表] Effects of acute ethanol and nicotine on radial-arm maze performance in mice models

Mostofa Jamal 2010

[学会発表] Effects of acute ethanol and nicotine onradial-arm maze performance in mice models

Mostofa Jamal 2010