研究成果

[雑誌論文] HCV-infected hepatocytes drive CD4+ CD25+ Foxp3+ regulatory T-cell development through the Tim-3/Gal-9 pathway.

Ji XJ, Ma CJ, Wang JM, Wu XY, Niki T,Hirashima M, Moorman JP, Yao ZQ 2013

[雑誌論文] Galectin-9 in cancer therapy

Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M, Masaki T. 2013

[雑誌論文] Galectin-9 functionally impairs natural killer cells in humans and mice.

Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. 2013

[雑誌論文] Galectin-9 Ameliorates Clinical Severity of MRL/lpr Lupus-Prone Mice by Inducing Plasma Cell Apoptosis Independently of Tim-3.

Moritoki M, Kadowaki T, Niki T, Nakano D, Soma G, Mori H, Kobara H, Masaki T, Kohno M, Hirashima M. 2013

[雑誌論文] Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner

Oomizu S 2012

[雑誌論文] TNFRSF25 Agonistic Antibody andGalectin-9 Combination Therapy Controls Herpes Simplex Virus-Induced Immunoinflammatory Lesions.

J Reddy PB, Schreiber TH, Rajasagi NK, Suryawanshi A, Mulik S, Veiga-Parga T, Niki T, Hirashima M, Podack ER, Rouse BT 2012

[雑誌論文] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection

S. Elahi, T. Niki, M. Hirashima, H. Horton. 2012

[雑誌論文] Rapid Decrease ofPlasma Galectin-9 Levels inPatients with Acute HIVInfection after Therapy

Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T. 2012

[雑誌論文] Galectin-9 ameliorates herpes simplex-induced inflammation through apoptosis

Shim JA, Park S, Lee ES, Niki T, Hirashima M, Sohn S 2012

[雑誌論文] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages.

Kadowaki T, Arikawa T, Shinonaga R, Oomizu S, Inagawa H, Soma G, Niki T, Hirashima M 2012

[雑誌論文] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9

MK. Gleason, TR. Lenvik, V. McCullar, M.Felices, MS. O'Brien, SA. Cooley, MR. Verneris, F. Cichocki, CJ. Holman, A.Panoskaltsis-Mortari, T. Niki, M.Hirashima, B.R. Blazar, JS. Miller 2012

[雑誌論文] Cell surface galectin-9 expressing th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion

Oomizu S, Arikawa T, Niki T, Kadowaki T, Ueno M, Nishi N, Yamauchi A, Hattori T, Masaki T, Hirashima M. 2012

[雑誌論文] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

Yang ZZ 2012

[雑誌論文] A novel monoclonal antibody fordetection ofgalectin-9 intissue sections: application tohuman tissues infected byoncogenic viruses.

Barjon C, Niki T, Verillaud B, Opolon P, Bedossa P,Hirashima M, Blanchin S, Wassef M, Rosen HR, Jimenez AS, Wei M, Busson P 2012

[雑誌論文] IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

ZZ. Yang, DM. Grote, SC. Ziesmer, T. Niki, M. Hirashima, AJ. Novak, TE. Wizig, SM. Ansell. 2012

[雑誌論文] The glycan-binding protein Galectin-9 has direct apoptotic activity towards melanoma cells

Wiersma VR, de Bruyn M, van Ginkel RJ, Sigar E, HirashimaM, Niki T, Nishi N, Samplonius DF, Helfrich W, Bremer E. 2012

[雑誌論文] Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages

Kadowaki T 2012

[雑誌論文] Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

Gleason MK, Lenvik TR, McCullar V, Felices M, O'Brien MS, Cooley SA, Verneris MR, Cichocki F, Holman CJ, Panoskaltsis-Mortari A, Niki T, Hirashima M, Blazar BR, Miller JS 2012

[雑誌論文] Galectin-9 ameliorates herpes simplex virus-induced inflammation through apoptosis

Shim JA 2012

[雑誌論文] Tim-3 is an inducible human NK cell receptor that enhances interferon gamma production in response to galectin-9

Gleason MK 2012

[雑誌論文] Endogenous galectin-1 and acute inflammation : emerging notion of a galectin-9 pro-resolving effect

Iqbal AJ 2011

[雑誌論文] Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages.

Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H. 2011

[雑誌論文] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells

Lv K 2011

[雑誌論文] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways.

Vega-Carrascal I, Reeves EP, Niki T, Arikawa T, McNally P, O'Neill SJ, Hirashima M, McElvaney NG. 2011

[雑誌論文] Galectin-9 attenuates acute lung injury by expanding CD14-plasmacytoid dendritic cell-like macrophages

Kojima K, Arikawa T, Saita N, Goto E, Tsumura S, Tanaka R, Masunaga A, Niki T, Oomizu S, Hirashima M, Kohrogi H 2011

[学会発表] 安定化ガレクチン9の開発と自己免疫疾患モデルでの有効性

仁木敏朗 2011

[雑誌論文] Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways

Vega-Carrascal I 2011

[雑誌論文] Endogenous galectin-1 and acute inflammation: emerging notion of a galectin-9 pro-resolving effect.

Iqbal AJ, Sampaio AL, Maione F, Greco KV, Niki T, Hirashima M, Perretti M, Cooper D. 2011

[雑誌論文] Galectin-9 administration ameliorates CVB3 induced myocarditis by promoting the proliferation of regulatory T cells and alternatively activated Th2 cells.

Lv K, Xu W, Wang C, Niki T, Hirashima M, Xiong S. 2011

[雑誌論文] Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells.

Rashmi Mishra, Michal Grzybek, Toshiro Niki, Mitsuomi Hirashima, Kai Simons. 2010

[雑誌論文] A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in chronic hepatitis C infection.

John A. Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica Randall, Rachel McMahan, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J. Polyak, Mitsuomi Hirashima, Hugo R. Rosen. 2010

[雑誌論文] Determination of carbohydratebinding preferences of human galectins with carbohydrate microarrays.

T.Horlacher, M A. Oberli, DB. Werz, LH. Krock, S. Bufali, B. Stocker, R. Mishra, J. Sobek, K. Simons, M. Hirashima, T. Niki, PH. Seeberger. 2010